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microRNA-155

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https://www.readbyqxmd.com/read/29325325/-expression-of-microrna-155-in-inflammatory-bowel-disease-and-its-clinical-significance
#1
Y L Ye, Z Pang, W Gu, J J Zheng
Objective: To explore the expression of microRNA-155 in colonic mucosa and peripheral blood in patients with inflammatory bowel disease(IBD), and to examine the clinical value and significance of microRNA-155 in the diagnosis of IBD. Methods: Quatitative reverse-transcription PCR was performed to detect the expression of microRNA-155 in 20 patients with Crohn disease(CD), 21 patients with ulcerative colitis (UC), 18 patients with IBD type unclassified(IBDU), 25 healthy people(control group), 12 patients with infection colitis and 19 patients with ischemia colitis...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29310731/formula-derived-maillard-reaction-products-in-post-weaning-intrauterine-growth-restricted-piglets-induce-developmental-programming-of-hepatic-oxidative-stress-independently-of-microrna-21-and-microrna-155
#2
S Firmin, G Elmhiri, D Crepin, M Souidi, M Taouis, L Abdennebi-Najar
We recently reported augmentation of lipid peroxidation products in the liver of intrauterine growth-restricted (IUGR) piglets fed a high load of Maillard reaction products (MRPs) during suckling period. The underlying mechanisms of MRPs effects remain unknown. Here, we studied the long-term impact of MRPs exposure on liver oxidative status of IUGR juvenile pigs. Livers of 54-day-old pigs suckled with formula containing either a high (HHF, n=8) or a low (LHF: n=8) load of MRPs were analyzed for protein carbonylation levels , activities and messenger RNA (mRNA) expression of glutathione (GSH) and main antioxidant regulators of redox homeostasis [Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were measured...
January 9, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29234238/mir-155-5p-modulates-malignant-behaviors-of-hepatocellular-carcinoma-by-directly-targeting-cthrc1-and-indirectly-regulating-gsk-3%C3%AE-involved-wnt-%C3%AE-catenin-signaling
#3
Gang Chen, Dongdong Wang, Xiongqi Zhao, Jun Cao, Yingpeng Zhao, Fan Wang, Jianhua Bai, Ding Luo, Li Li
Background: Hepatocellular carcinoma (HCC) remains one of the most lethal cancers. MicroRNA-155 (miR-155) and collagen triple helix repeat containing 1 (CTHRC1) were found to be involved in hepatocarcinogenesis, but their detailed functions in HCC are unclear. Here, we aimed to investigate the underlying role of miR-155-5p and CTHRC1 in HCC. Methods: miR-155-5p and CTHRC1 expression levels were detected by qRT-PCR, IHC and WB in HCC patients and cell lines. Dual-luciferase assay, qRT-PCR and WB were used to validate the target interaction between miR-155-5p and CTHRC1...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29228427/mir-155-regulates-lymphoma-cell-proliferation-and-apoptosis-through-targeting-socs3-jak-stat3-signaling-pathway
#4
X-D Li, X-M Li, J-W Gu, X-C Sun
OBJECTIVE: Janus kinase (JAK)- signal transducer and activator of transcription (STAT) signaling pathway participates in regulating cell proliferation, differentiation, and apoptosis, and related to lymphoma. Suppressors of cytokine signaling 3 (SOCS3) is a negative regulator of the JAK-STAT signaling pathway. SOCS3 reduction and miR-155 up-regulation are associated with lymphoma pathogenesis. Bioinformatics analysis showed the complementary binding site between miR-155 and SOCS3. This study aimed to investigate the role of miR-155 in regulating SOCS3/JAK-STAT signaling pathway and affecting diffuse large B cell lymphoma (DLBCL) cell proliferation and apoptosis...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228417/mir-155-affects-renal-carcinoma-cell-proliferation-invasion-and-apoptosis-through-regulating-gsk-3%C3%AE-%C3%AE-catenin-signaling-pathway
#5
R-J Wei, C-H Zhang, W-Z Yang
OBJECTIVE: Glycogen Synthase Kinase-3β (GSK-3β) negatively regulates Wnt/β-catenin signaling pathway through degrading β-catenin protein. It plays an inhibitory role in various tumors, while the influence in the pathogenesis of renal carcinoma has not been elucidated. MicroRNA-155 (MiR-155) was found to be upregulated in renal carcinoma tissue. Bioinformatics analysis revealed the complementary binding site between miR-155 and 3'-UTR of GSK-3β. This study investigated the influence of miR-155 in regulating GSK-3β expression, Wnt/β-catenin signaling pathway activity, and renal carcinoma cell proliferation, invasion, and apoptosis...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29217774/microrna-155-is-a-direct-target-of-meis1-but-not-a-driver-in-acute-myeloid-leukemia
#6
Edith Schneider, Anna Staffas, Linda Röhner, Erik D Malmberg, Arghavan Ashouri, Kathrin Krowiorz, Nicole Pochert, Christina Miller, Stella Yuan Wei, Laleh Arabanian, Christian Buske, Hartmut Döhner, Lars Bullinger, Linda Fogelstrand, Michael Heuser, Konstanze Döhner, Ping Xiang, Jens Ruschmann, Oleh I Petriv, Alireza Heravi-Moussavi, Carl L Hansen, Martin Hirst, R Keith Humphries, Arefeh Rouhi, Lars Palmqvist, Florian Kuchenbauer
MicroRNA-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155 to be a direct target of Meis1 in murine Hoxa9/Meis1 induced acute myeloid leukemia. The additional overexpression of miR 155 accelerated the formation of acute myeloid leukemia in Hoxa9 as well as in Hoxa9/Meis1 cells in vivo. However, in the absence or after the removal of miR-155, leukemia onset and progression were unaffected...
December 7, 2017: Haematologica
https://www.readbyqxmd.com/read/29198110/a-novel-and-label-free-platform-for-microrna-detection-based-on-the-fluorescence-quenching-of-positively-charged-gold-nanoparticles-to-ag-nanoclusters
#7
Xiangmin Miao, Zhiyuan Cheng, Haiyan Ma, Zongbing Li, Ning Xue, Po Wang
A novel strategy was developed for microRNA-155 (miRNA-155) detection based on the fluorescence quenching of positively charged gold nanoparticles ((+)AuNPs) to Ag nanoclusters (AgNCs). In the designed system, DNA-stabilized Ag nanoclusters (DNA/AgNCs) were introduced as fluorescent probes, and DNA-RNA heteroduplexes were formed upon the addition of target miRNA-155. Meanwhile, the (+)AuNPs could be electrostatically adsorbed on the negatively charged single-stranded DNA (ssDNA) or DNA-RNA heteroduplexes to quench the fluorescence signal...
December 4, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29146158/plasma-microrna-155-5p-is-increased-among-patients-with-chronic-kidney-disease-and-nocturnal-hypertension
#8
Dominika Klimczak, Marek Kuch, Tomasz Pilecki, Dorota Żochowska, Agnieszka Wirkowska, Leszek Pączek
MicroRNAs play multiple roles in the regulation of blood pressure (BP). Nevertheless, to date, no study has assessed the association between microRNA plasma expression and BP control in chronic kidney disease (CKD) patients. Given this background, we evaluated the plasma expression of miR-155-5p, a translational inhibitor of angiotensin receptor type I, in CKD patients, to determine the association between miR-155-5p level and BP control. In this single-center cross-sectional study, we analyzed the miR-155-5p concentration by quantitative reverse transcriptase polymerase chain reaction using the U6 snRNA as a reference gene and 24-hour ambulatory blood pressure monitoring in CKD patients (stage ≥2) in relation to a control group of healthy age-matched and gender-matched individuals, with normal BP proven by the ambulatory blood pressure monitoring...
December 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29136142/the-forkhead-transcription-factor-foxo3-negatively-regulates-natural-killer-cell-function-and-viral-clearance-in-myocarditis
#9
Madlen Loebel, Luise Holzhauser, Jelka A Hartwig, Praphulla C Shukla, Konstantinos Savvatis, Alexander Jenke, Martina Gast, Felicitas Escher, Sonya C Becker, Sandra Bauer, Andrea Stroux, Antje Beling, Meike Kespohl, Sandra Pinkert, Henry Fechner, Uwe Kuehl, Dirk Lassner, Wolfgang Poller, Heinz-Peter Schultheiss, Tanja Zeller, Stefan Blankenberg, Anna-Pia Papageorgiou, Stephane Heymans, Ulf Landmesser, Carmen Scheibenbogen, Carsten Skurk
Aims: Foxo3 is a transcription factor involved in cell metabolism, survival, and inflammatory disease. However, mechanistic insight in Foxo3 effects is still limited. Here, we investigated the role of Foxo3 on natural killer (NK) cell responses and its effects in viral myocarditis. Methods and results: Effects of Foxo3 on viral load and immune responses were investigated in a model of coxsackie virus B3 myocarditis in wild-type (WT) and Foxo3 deficient mice. Reduced immune cell infiltration, viral titres, and pro-inflammatory cytokines in cardiac tissue were observed in Foxo3-/- mice 7 days post-infection (p...
November 9, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29115566/downregulation-of-microrna%C3%A2-155-by-preoperative-administration-of-valproic-acid-prevents-postoperative-seizures-by-upregulating-scn1a
#10
Zhijie Zhang, Zhenzhong Wang, Bo Zhang, Yan Liu
The risk of seizure is increased following brain surgery such as cranioplasty. Patients with seizures that are treated with valproic acid (VPA) may have a decreased risk of further seizures. To verify microRNA (miR)‑155 as a potential biomarker for the occurrence of seizures, reverse transcription quantitative polymerase chain reaction (RT‑qPCR) was used. Computational analysis and luciferase reporter assay was performed to identify the putative target of miR‑155. RT‑qPCR and western blot analyses were used to determine the expression level of miR‑155, sodium voltage‑gated channel α subunit 1 (SCN1A) mRNA and protein...
November 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29105307/role-of-microrna-155-in-rheumatoid-arthritis
#11
REVIEW
Lin-Chong Su, An-Fang Huang, Hong Jia, Yi Liu, Wang-Dong Xu
MicroRNAs (miRNAs) are a recently discovered class of post-transcriptional regulators that induce target messenger RNA degradation or translation inhibition. miRNA-155 (miR-155) is an important regulator of immune cells both in humans and mice, by which these cells play critical roles in the pathogenesis of rheumatoid arthritis (RA). Recent findings showed that expression of miR-155 was elevated in RA patients and arthritis models. Moreover, miR-155 overexpression or knockdown performed significantly in the development of arthritis...
November 3, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29104649/small-interfering-rna-directed-against-microrna-155-delivered-by-a-lentiviral-vector-attenuates-asthmatic-features-in-a-mouse-model-of-allergic-asthma
#12
Huilong Chen, Xiangqin Xu, Sheng Cheng, Yuzhu Xu, Qi Xuefei, Yong Cao, Jungang Xie, Cong-Yi Wang, Yongjian Xu, Weining Xiong
Asthma is a chronic T helper type 2 (Th2) cell-mediated inflammatory disease characterized by airway hyperresponsiveness (AHR) and airway inflammation. Although the majority of patients with asthma can achieve a good level of control with existing treatments, asthma runs a chronic course and the effectiveness of current treatment is not satisfactory for certain patients. MicroRNAs (miRNAs) are short noncoding RNAs that suppress gene expression at the post-transcriptional level; their role in regulating allergic inflammation remains largely unknown...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29104623/microrna-155-regulates-the-proliferation-cell-cycle-apoptosis-and-migration-of-colon-cancer-cells-and-targets-cbl
#13
Hua Yu, Weiling Xu, Fangchao Gong, Baorong Chi, Junyi Chen, Ling Zhou
MicroRNA-155 (miR-155) is a well-studied miR and acts as an oncomiR in numerous cancer types. However, the biological functions of miR-155 in colon cancer as well as its target genes have remained to be fully elucidated. In order to investigate the biological functions of miR-155, MTT, colony formation and wound healing assays, cell cycle analysis and detection of apoptosis were performed. The results demonstrated that miR-155 promoted the proliferation of colon cancer cells and enhanced their colony formation capacity, promoted their cell cycle progression and inhibited apoptosis...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29091308/in-vivo-and-in-vitro-effects-of-pth1-34-on-osteogenic-and-adipogenic-differentiation-of-human-bone-marrow-derived-mesenchymal-stem-cells-through-regulating-microrna-155
#14
Huan-Sheng Han, Fang Ju, Shuo Geng
This study aimed to investigate the effect of parathyroid hormone (PTH1-34) on osteogenic and adipogenic differentiation of hBMSCs by the regulation of miR-155. A total of 36 adult volunteers were selected in this study. Effects of PTH1-34 on the proliferation of hBMSCs and miR-155 expression were investigated using a MTT assay. The hBMSCs were divided into blank, PTH1-34, miR-155 mimic, miR-155 mimic negative control (NC), miR-155 inhibitor, miR-155 inhibitor NC, PTH1-34 + miR-155 mimic, PTH1-34 + miR-155 inhibitor and NPS R-568 groups...
November 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29079998/role-of-3-acetyl-11-keto-beta-boswellic-acid-in-counteracting-lps-induced-neuroinflammation-via-modulation-of-mirna-155
#15
Aya Shoukry Sayed, Iman Emam Omar Gomaa, Michael Bader, Nesrine Salah El Dine El Sayed
Neuroinflammation is one of the most important mechanisms underlying neurodegeneration. Lipopolysaccharide (LPS) is a potent inflammogen which causes cognitive dysfunction. Boswellia serrata is known since many years as a powerful anti-inflammatory herbal drug. Its beneficial effect mainly arises from inhibition of 5-lipoxygenase (5-LO) enzyme. 3-acetyl-11-keto-β-boswellic acid (AKBA) is the most potent 5-LO inhibitor extracted from the oleo-gum-resin of Boswellia serrata. The aim of the present work is to study the molecular mechanisms underlying the anti-inflammatory and neuroprotective effects of AKBA and dexamethasone (DEX) in LPS-induced neuroinflammatory model...
October 27, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29066622/microrna-155-induction-via-tnf-%C3%AE-and-ifn-%C3%AE-suppresses-expression-of-programmed-death-ligand-1-pd-l1-in-human-primary-cells
#16
Daniel Yee, Kunal M Shah, Mark C Coles, Tyson V Sharp, Dimitris Lagos
Programmed death ligand-1 (PD-L1) is a critical regulator of T cell function contributing to peripheral immune tolerance. Although it has been shown that posttranscriptional regulatory mechanisms control PD-L1 expression in cancer, it remains unknown whether such regulatory loops operate also in non-transformed cells. Here we studied PD-L1 expression in human dermal lymphatic endothelial cells (HDLECs), which play key roles in immunity and cancer. Treatment of HDLECs with the pro-inflammatory cytokines IFN-γ and TNF-α synergistically upregulated PDL1 expression...
October 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29018442/lower-expression-of-microrna-155-contributes-to-dysfunction-of-natural-killer-cells-in-patients-with-chronic-hepatitis-b
#17
Jun Ge, Zuxiong Huang, Hongyan Liu, Jiehua Chen, Zhanglian Xie, Zide Chen, Jie Peng, Jian Sun, Jinlin Hou, Xiaoyong Zhang
MicroRNAs have been reported to be regulated in different ways in a variety of liver diseases. As a key modulator of cellular function in both innate and adaptive immunity, the role of miR-155 in chronic hepatitis B virus infection remains largely unknown. Here, we investigated the expression and function of miR-155 in chronic hepatitis B (CHB) patients. It was found that miR-155 expression in peripheral blood mononuclear cells (PBMCs) was lower in CHB patients than healthy controls (HC). Among CHB infection, immune-active (IA) patients with abnormal alanine aminotransferase (ALT) levels had relatively higher miR-155 expression in PBMCs and serum than immune-tolerant carriers, but were comparable to inactive carriers...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29017169/ox-ldl-induced-microrna-155-promotes-autophagy-in-human-endothelial-cells-via-repressing-the-rheb-mtor-pathway
#18
Jinlin Lv, Lixia Yang, Ruiwei Guo, Yankun Shi, Ziwei Zhang, Jinshan Ye
BACKGROUND/AIMS: Autophagy, an evolutionary conserved biological process, is activated in cells to cope with various types of stress. MicroRNAs control several activities related to autophagy. However, the role of autophagy-related microRNAs during atherosclerosis is far from known. MicroRNA-155 was identified to be a crucial regulator of atherosclerosis. The objectives of the study were to analyze the effect of microRNA-155 on autophagic signaling and explore its mechanism in human endothelial cells under ox-LDL stress...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28993299/circulating-micrornas-as-a-biomarker-to-predict-therapy-efficacy-in-hepatitis-c-patients-with-different-genotypes
#19
Zhicheng Fan, Qiaoxin Zhang, Huanzhu Chen, Ping He, Yazhen Li, Mengya Si, Xiaoyang Jiao
BACKGROUND: Hepatitis C virus (HCV) genotype exerts a major influence on therapeutic response; however, the underlying mechanisms remain unclear. The aim of the study is to investigate the circulating microRNAs as the biomarkers to predict the response to therapy in chronic hepatitisC patients (HepC) with different genotypes. METHODS: HepC patients were separated into 4 groups by genotype, healthy individuals were enrolled as the control. microRNA-122 (miR-122), microRNA-155 (miR-155) and HCV RNA in serum and exosome were measured, associations between microRNAs, viral load and other conventional biomarkers were analyzed...
October 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28970282/hyperlipidemia-induced-microrna-155-5p-improves-%C3%AE-cell-function-by-targeting-mafb
#20
Mengyu Zhu, Yuanyuan Wei, Claudia Geißler, Kathrin Abschlag, Judit Corbalán Campos, Michael Hristov, Julia Möllmann, Michael Lehrke, Ela Karshovska, Andreas Schober
A high-fat diet increases bacterial lipopolysaccharide (LPS) in the circulation, and thereby stimulates glucagon-like peptide-1 (GLP-1)-mediated insulin secretion by up-regulating interleukin (IL)-6. Although microRNA-155-5p (miR-155-5p), which increases IL-6 expression, is upregulated by LPS and hyperlipidemia, and patients with familial hypercholesterolemia less frequently develop diabetes, the role of miR-155-5p in the islet stress response to hyperlipidemia is unclear. Here, we demonstrate that hyperlipidemia-associated endotoxemia up-regulates miR-155-5p in murine pancreatic β-cells, which improved glucose metabolism and the adaptation of β-cells to obesity-induced insulin resistance...
September 29, 2017: Diabetes
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