Elin Svedlund Eriksson, Inger Johansson, Anna K F Mårtensson, Marta Lantero Rodriguez, Maaike Schilperoort, Jan Kroon, Sander Kooijman, Elmir Omerovic, Linda Andersson, Malin C Levin, Patrick C N Rensen, Åsa Tivesten
Androgen deprivation therapy of prostate cancer, which suppresses serum testosterone to castrate levels, is associated with increased risk of heart failure. Here we tested the hypothesis that castration alters cardiac energy substrate uptake, which is tightly coupled to the regulation of cardiac structure and function. Short-term (3-4 weeks) surgical castration of male mice reduced the relative heart weight. While castration did not affect cardiac function in unstressed conditions, we observed reductions in heart rate, stroke volume, cardiac output, and cardiac index during pharmacological stress with dobutamine in castrated vs sham-operated mice...
October 11, 2022: Journal of the Endocrine Society