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telomere length and lifestyle change

Ivan Dimauro, Mattia Scalabrin, Cristina Fantini, Elisa Grazioli, Maria Reyes Beltran Valls, Neri Mercatelli, Attilio Parisi, Stefania Sabatini, Luigi Di Luigi, Daniela Caporossi
Regular physical activity is effective as prevention and treatment for different chronic conditions related to the ageing processes. In fact, a sedentary lifestyle has been linked to a worsening of cellular ageing biomarkers such as telomere length (TL) and/or specific epigenetic changes (e.g. DNA methylation), with increase of the propensity to aging-related diseases and premature death. Extending our previous findings, we aimed to test the hypothesis that 12 weeks of low frequency, moderate intensity, explosive-type resistance training (EMRT) may attenuate age-associated genomic changes...
September 21, 2016: Redox Biology
Sarah Appleby, John F Pearson, Alan Aitchison, Janet K Spittlehouse, Peter R Joyce, Martin A Kennedy
OBJECTIVES: Telomeres are nucleoprotein complexes that cap the ends of linear chromosomes. Telomeric DNA decreases with age and shows considerable heterogeneity in the wider population. There is interest in the application of telomere length measures as a biomarker of general health or "biological age," and the possibility of using mean telomere length to gauge individual disease risk, and to promote lifestyle changes to improve health. This study examined the effectiveness of telomere length as a biomarker for an individual's current overall health status by assessing several measures of general health including SF-36v2 score, current smoking status and a comprehensive obesity phenotype...
August 26, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
Cynthia A Thomson, Tracy E Crane, Austin Miller, David O Garcia, Karen Basen-Engquist, David S Alberts
Ovarian cancer is the most common cause of gynecological cancer death in United States women. Efforts to improve progression free survival (PFS) and quality of life (QoL) after treatment for ovarian cancer are necessary. Observational studies suggest that lifestyle behaviors, including diet and physical activity, are associated with lower mortality in this population. The Lifestyle Intervention for Ovarian Cancer Enhanced Survival (LIVES) NRG 0225 study is a randomized, controlled trial designed to test the hypothesis that a 24month lifestyle intervention will significantly increase PFS after oncological therapy for stage II-IV ovarian cancer...
July 2016: Contemporary Clinical Trials
D Révész, J E Verhoeven, Y Milaneschi, B W J H Penninx
BACKGROUND: Depressive and anxiety disorders are associated with shorter leukocyte telomere length (LTL), an indicator of cellular aging. It is, however, unknown which pathways underlie this association. This study examined the extent to which lifestyle factors and physiological changes such as inflammatory or metabolic alterations mediate the relationship. METHOD: We applied mediation analysis techniques to data from 2750 participants of the Netherlands Study of Depression and Anxiety...
August 2016: Psychological Medicine
Jue Lin, Joshua Cheon, Rashida Brown, Michael Coccia, Eli Puterman, Kirstin Aschbacher, Elizabeth Sinclair, Elissa Epel, Elizabeth H Blackburn
Telomeres, the protective DNA-protein complexes at the ends of linear chromosomes, are important for genome stability. Leukocyte or peripheral blood mononuclear cell (PBMC) telomere length is a potential biomarker for human aging that integrates genetic, environmental, and lifestyle factors and is associated with mortality and risks for major diseases. However, only a limited number of studies have examined longitudinal changes of telomere length and few have reported data on sorted circulating immune cells...
2016: Journal of Immunology Research
Josine E Verhoeven, Patricia van Oppen, Dóra Révész, Owen M Wolkowitz, Brenda W J H Penninx
OBJECTIVE: Several cross-sectional studies have related depressive and anxiety disorders to shorter leukocyte telomere length (LTL) as an indicator of cellular aging. However, these studies have left many unresolved questions about underlying causality and ordering of associations. The objective of the present large, longitudinal study was to examine the relationship between depressive and anxiety disorders and LTL over a 6-year time period. METHOD: Data are from the Netherlands Study of Depression and Anxiety, including 2,292 patients with remitted and current diagnoses of depressive or anxiety disorders and 644 healthy control subjects...
June 1, 2016: American Journal of Psychiatry
Dóra Révész, Yuri Milaneschi, Erik M Terpstra, Brenda W J H Penninx
BACKGROUND: Short leukocyte telomere length (TL) and accelerated telomere attrition have been associated with various deleterious health outcomes, although their determinants have not been explored collectively in a large-scale study. MATERIAL AND METHODS: Leukocyte TL was measured (baseline N=2936; 6-year follow-up N=1860) in participants (18-65 years) from the NESDA study. Baseline determinants of TL included sociodemographics, lifestyle, chronic diseases, psychosocial stressors, and metabolic and physiological stress markers...
May 2016: Psychoneuroendocrinology
Stefan Enroth, Sofia Bosdotter Enroth, Åsa Johansson, Ulf Gyllensten
Ageing is linked to a number of changes in how the body and its organs function. On a molecular level, ageing is associated with a reduction of telomere length, changes in metabolic and gene-transcription profiles and an altered DNA-methylation pattern. Lifestyle factors such as smoking or stress can impact some of these molecular processes and thereby affect the ageing of an individual. Here we demonstrate by analysis of 77 plasma proteins in 976 individuals, that the abundance of circulating proteins accurately predicts chronological age, as well as anthropometrical measurements such as weight, height and hip circumference...
2015: Scientific Reports
Dóra Révész, Yuri Milaneschi, Josine E Verhoeven, Jue Lin, Brenda W J H Penninx
CONTEXT: Deterioration of metabolic syndrome (MetS) has been associated with short telomere length (TL). Large-scale longitudinal studies with repeated measures of MetS and TL are lacking. OBJECTIVES: We examined whether baseline MetS components predict TL over time, and whether deteriorations in MetS parallel telomere attrition. DESIGN AND SETTING: Participants were part of The Netherlands Study of Depression and Anxiety, an ongoing prospective cohort study...
August 2015: Journal of Clinical Endocrinology and Metabolism
J J Soler, C Ruiz Castellano, J Martínez-de la Puente, G Tomás, M Ruiz-Rodríguez, J Figuerola
Although little is known on the impact of environment on telomere length dynamics, it has been suggested to be affected by stress, lifestyle and/or life-history strategies of animals. We here compared telomere dynamics in erythrocytes of hatchlings and fledglings of the brood parasite great spotted cuckoos (Clamator glandarius) and of magpies (Pica pica), their main host in Europe. In magpie chicks, telomere length decreased from hatching to fledging, whereas no significant change in telomere length of great spotted cuckoo chicks was found...
September 2015: Journal of Evolutionary Biology
S Toupance, G Watfa, C Lakomy, A Kearney-Schwartz, C Labat, P Rossignol, P Lacolley, F Zannad, A Benetos
OBJECTIVE: Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival in the elderly. The prevailing view is that LTL is associated with accelerated aging since it serves as a biomarker of the cumulative burden of inflammation and oxidative stress during adult life. However LTL dynamics are mainly defined by LTL at birth, which is highly variable, and its age-dependent attrition thereafter, which is rapid during the first 20 years of life...
June 2015: Journal of Hypertension
Wong-Ho Chow, Matthew Chrisman, Carrie R Daniel, Yuanqing Ye, Henry Gomez, Qiong Dong, Chelsea E Anderson, Shine Chang, Sara Strom, Hua Zhao, Xifeng Wu
Hispanic Americans comprise the largest and fastest-growing ethnic minority in the USA. In Houston, Texas, 44% of the population is of Hispanic descent, with the majority being Mexican Americans (78%). This population is under-represented in health-related research despite their high prevalence of obesity and diabetes, which may predispose them to cancer and other chronic conditions. Recognizing the need for a greater research effort into the health risks of Hispanic Americans, the population-based Mexican American (Mano a Mano) Cohort study was launched in 2001...
March 8, 2015: International Journal of Epidemiology
Sonia García-Calzón, Miguel A Martínez-González, Cristina Razquin, Dolores Corella, Jordi Salas-Salvadó, J Alfredo Martínez, Guillermo Zalba, Amelia Marti
BACKGROUND: The gene variant Pro/Ala (rs1801282) in the PPARγ2 has been associated with lower cardiovascular risk and greater benefit from lifestyle interventions. This polymorphism also seems to be associated with longer lifespan, but no information on telomere length (TL) is available. Our aim was to study the association between the Ala allele and changes in TL in high cardiovascular risk subjects and the potential interaction with a Mediterranean dietary pattern. METHODS AND RESULTS: A total of 521 subjects (55-80 years) participating in the Prevención con Dieta Mediterránea randomized trial were genotyped...
February 2015: Circulation. Cardiovascular Genetics
Dana A Glei, Noreen Goldman, Maxine Weinstein, Rosa Ana Risques
Recent studies have found mixed results regarding the association between leukocyte telomere length (LTL)--thought to be a marker of cellular aging--and all-cause mortality. Some studies have reported a significant inverse relationship, but others have not, perhaps in part owing to insufficient power. We examine the relationship using data from a nationally representative sample of older Taiwanese (54+ in 2000), which is larger (n = 942) than most previous studies, and which includes comprehensive information on potential confounders including white blood cell distribution and inflammatory markers...
December 2015: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Aneta Balcerczyk, Agnieszka Gajewska, Ewa Macierzyńska-Piotrowska, Tomasz Pawelczyk, Grzegorz Bartosz, Janusz Szemraj
A growing number of studies confirm an important effect of diet, lifestyle and physical activity on health status, the ageing process and many metabolic disorders. This study focuses on the influence of a diet supplement, NucleVital®Q10 Complex, on parameters related to redox homeostasis and ageing. An experimental group of 66 healthy volunteer women aged 35-55 supplemented their diet for 12 weeks with the complex, which contained omega-3 acids (1350 mg/day), ubiquinone (300 mg/day), astaxanthin (15 mg/day), lycopene (45 mg/day), lutein palmitate (30 mg/day), zeaxanthine palmitate (6 mg/day), L-selenomethionine (330 mg/day), cholecalciferol (30 µg/day) and α-tocopherol (45 mg/day)...
2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Per Sjögren, Rachel Fisher, Lena Kallings, Ulrika Svenson, Göran Roos, Mai-Lis Hellénius
BACKGROUND: Telomere length has been associated with a healthy lifestyle and longevity. However, the effect of increased physical activity on telomere length is still unknown. Therefore, the aim was to study the relationship between changes in physical activity level and sedentary behaviour and changes in telomere length. METHODS: Telomere length was measured in blood cells 6 months apart in 49, 68-year-old, sedentary, overweight individuals taking part in a randomised controlled physical activity intervention trial...
October 2014: British Journal of Sports Medicine
Mark A Babizhayev, Anne Kasus-Jacobi, Khava S Vishnyakova, Yegor E Yegorov
Telomere length is emerging as a biomarker for aging and survival is paternally inherited and associated with parental lifespan. Telomere-associated cellular senescence may contribute to certain age-related disorders, including an increase in cancer incidence, wrinkling and diminished skin elasticity, atherosclerosis, osteoporosis, weight loss, age-related cataract, glaucoma and others. Shorter telomere length in leukocytes was associated cross-sectionally with cardiovascular disorders and its risk factors, including pulse pressure and vascular aging, obesity, vascular dementia, diabetes, coronary artery disease, myocardial infarction (although not in all studies), cellular turnover and exposure to oxidative and inflammatory damage in chronic obstructive pulmonary disease...
2014: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Carola Ingrid Weidner, Qiong Lin, Carmen Maike Koch, Lewin Eisele, Fabian Beier, Patrick Ziegler, Dirk Olaf Bauerschlag, Karl-Heinz Jöckel, Raimund Erbel, Thomas Walter Mühleisen, Martin Zenke, Tim Henrik Brümmendorf, Wolfgang Wagner
BACKGROUND: Human aging is associated with DNA methylation changes at specific sites in the genome. These epigenetic modifications may be used to track donor age for forensic analysis or to estimate biological age. RESULTS: We perform a comprehensive analysis of methylation profiles to narrow down 102 age-related CpG sites in blood. We demonstrate that most of these age-associated methylation changes are reversed in induced pluripotent stem cells (iPSCs). Methylation levels at three age-related CpGs--located in the genes ITGA2B, ASPA and PDE4C--were subsequently analyzed by bisulfite pyrosequencing of 151 blood samples...
2014: Genome Biology
Jeanne S Mandelblatt, Arti Hurria, Brenna C McDonald, Andrew J Saykin, Robert A Stern, John W VanMeter, Meghan McGuckin, Tiffani Traina, Neelima Denduluri, Scott Turner, Darlene Howard, Paul B Jacobsen, Tim Ahles
There is a fairly consistent, albeit non-universal body of research documenting cognitive declines after cancer and its treatments. While few of these studies have included subjects aged 65 years and older, it is logical to expect that older patients are at risk of cognitive decline. Here, we use breast cancer as an exemplar disease for inquiry into the intersection of aging and cognitive effects of cancer and its therapies. There are a striking number of common underlying potential biological risks and pathways for the development of cancer, cancer-related cognitive declines, and aging processes, including the development of a frail phenotype...
December 2013: Seminars in Oncology
Laila Bendix, Mikael Thinggaard, Mogens Fenger, Steen Kolvraa, Kirsten Avlund, Allan Linneberg, Merete Osler
BACKGROUND: Leukocyte telomere length (LTL) ostensibly shortens with age and has been moderately associated with mortality. In humans, these findings have come almost solely from cross-sectional studies. Only recently has LTL shortening within individuals been analyzed in longitudinal studies. Such studies are relevant to establish LTL dynamics as biomarkers of mortality as well as to disentangle the causality of telomeres on aging. METHODS: We present a large longitudinal study on LTL and human mortality, where the 10-year change of LTL is analyzed in 1,356 individuals aged 30-70 years...
February 2014: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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