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telomere length and lifestyle change

Hua Zhao, Lixia Han, David Chang, Yuanqing Ye, Jie Shen, Carrie R Daniel, Jian Gu, Wong-Ho Chow, Xifeng Wu
In the current study, we examined cross-sectional associations among social-demographics, lifestyle behaviors, and relative telomere length (RTL) in peripheral blood leukocytes, as well as longitudinal relationships among major chronic diseases, weight gain, and RTL, among 12,792 Mexican Americans aged 20 to 85 years in the Mano-A-Mano, the Mexican American Cohort. As expected, RTL was inversely correlated with age ( ρ =-0.15, ρ <0.001). In the multivariate analysis, we found that RTL was positively correlated with levels of education ( ρ =0...
November 14, 2017: Oncotarget
Dóra Révész, Josine E Verhoeven, Martin Picard, Jue Lin, Stephen Sidney, Elissa S Epel, Brenda W J H Penninx, Eli Puterman
Background: Metabolic syndrome (MetS) is thought to promote biological aging, which might lead to cardiovascular and aging-related complications. This large-scale study investigated longitudinal relationships between MetS, its components, and cellular aging markers: leukocyte mitochondrial DNA copy number (mtDNAcn) and telomere length (TL). Methods: We included 989 participants from the Coronary Artery Risk Development in Young Adults Study. MtDNAcn [study year (Y) 15, Y25] and TL (Y15, Y20, Y25) were measured via quantitative polymerase chain reaction...
January 1, 2018: Journal of Clinical Endocrinology and Metabolism
Shireen Sindi, Tiia Ngandu, Iiris Hovatta, Ingemar Kåreholt, Riitta Antikainen, Tuomo Hänninen, Esko Levälahti, Tiina Laatikainen, Jaana Lindström, Teemu Paajanen, Markku Peltonen, Dharma Singh Khalsa, Benjamin Wolozin, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto, Alina Solomon
Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle intervention (exploratory analyses). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial including 1,260 people at risk of cognitive decline, aged 60-77 years identified from the general population...
2017: Journal of Alzheimer's Disease: JAD
Mohamed Ali Alzain, Collins Otieno Asweto, Jie Zhang, Honghong Fang, Zhongyao Zhao, Xiuhua Guo, Manshu Song, Yong Zhou, Naibai Chang, Youxin Wang, Wei Wang
Suboptimal health status (SHS) has been linked to cardiovascular risk factors, psychosocial stress, and unhealthy lifestyle. These factors also contribute to the shortening of telomere length (TL). A case-control study was conducted to examine the association between subjective health measures of SHS from the behavior perspective and also objective measures of TL at molecular level. SHS (cases = 294) was matched by age, sex, and body mass index with ideal health (controls = 294) using a propensity score matching method...
June 2017: Omics: a Journal of Integrative Biology
U Magnet, C Urbanek, D Gaisberger, E Tomeva, E Dum, A Pointner, A G Haslberger
OBJECTIVE: Equol has been shown to improve skin health and regeneration, due to its antioxidative, phytoestrogenic and epigenetic characteristics. The effects of a topical intervention on skin structure, telomere length and epigenetic markers in skin cells were analysed. METHODS: Sixty-four participants were divided in four groups and three of them treated topically with the following: emulsion with Equol powder (Isoflavandiol-E-55-RS®); emulsion with microencapsulated Equol (Vesisorb® Isoflavandiol-E-55-RS®) and an emulsion with lecithin (Vesisorb® placebo)...
October 2017: International Journal of Cosmetic Science
H Peng, F Yeh, J Lin, L G Best, S A Cole, E T Lee, B V Howard, J Zhao
Essentials Plasminogen activator inhibitor-1 (PAI-1) advanced cellular senescence in experiment studies. No population study exists on the association between PAI-1 and biological aging in American Indians. We found cross-sectional and longitudinal associations between higher PAI-1 and shorter telomere length. Our findings suggest a pathway linking PAI-1 with biological aging beyond metabolic factors. SUMMARY: Background Plasminogen activator inhibitor-1 (PAI-1) promotes cellular aging both in vitro and in vivo...
June 2017: Journal of Thrombosis and Haemostasis: JTH
Madhuri Tolahunase, Rajesh Sagar, Rima Dada
This study was designed to explore the impact of Yoga and Meditation based lifestyle intervention (YMLI) on cellular aging in apparently healthy individuals. During this 12-week prospective, open-label, single arm exploratory study, 96 apparently healthy individuals were enrolled to receive YMLI. The primary endpoints were assessment of the change in levels of cardinal biomarkers of cellular aging in blood from baseline to week 12, which included DNA damage marker 8-hydroxy-2'-deoxyguanosine (8-OH2dG), oxidative stress markers reactive oxygen species (ROS), and total antioxidant capacity (TAC), and telomere attrition markers telomere length and telomerase activity...
2017: Oxidative Medicine and Cellular Longevity
Ivan Dimauro, Mattia Scalabrin, Cristina Fantini, Elisa Grazioli, Maria Reyes Beltran Valls, Neri Mercatelli, Attilio Parisi, Stefania Sabatini, Luigi Di Luigi, Daniela Caporossi
Regular physical activity is effective as prevention and treatment for different chronic conditions related to the ageing processes. In fact, a sedentary lifestyle has been linked to a worsening of cellular ageing biomarkers such as telomere length (TL) and/or specific epigenetic changes (e.g. DNA methylation), with increase of the propensity to aging-related diseases and premature death. Extending our previous findings, we aimed to test the hypothesis that 12 weeks of low frequency, moderate intensity, explosive-type resistance training (EMRT) may attenuate age-associated genomic changes...
December 2016: Redox Biology
Sarah Appleby, John F Pearson, Alan Aitchison, Janet K Spittlehouse, Peter R Joyce, Martin A Kennedy
OBJECTIVES: Telomeres are nucleoprotein complexes that cap the ends of linear chromosomes. Telomeric DNA decreases with age and shows considerable heterogeneity in the wider population. There is interest in the application of telomere length measures as a biomarker of general health or "biological age," and the possibility of using mean telomere length to gauge individual disease risk, and to promote lifestyle changes to improve health. This study examined the effectiveness of telomere length as a biomarker for an individual's current overall health status by assessing several measures of general health including SF-36v2 score, current smoking status and a comprehensive obesity phenotype...
January 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
Cynthia A Thomson, Tracy E Crane, Austin Miller, David O Garcia, Karen Basen-Engquist, David S Alberts
Ovarian cancer is the most common cause of gynecological cancer death in United States women. Efforts to improve progression free survival (PFS) and quality of life (QoL) after treatment for ovarian cancer are necessary. Observational studies suggest that lifestyle behaviors, including diet and physical activity, are associated with lower mortality in this population. The Lifestyle Intervention for Ovarian Cancer Enhanced Survival (LIVES) NRG 0225 study is a randomized, controlled trial designed to test the hypothesis that a 24month lifestyle intervention will significantly increase PFS after oncological therapy for stage II-IV ovarian cancer...
July 2016: Contemporary Clinical Trials
D Révész, J E Verhoeven, Y Milaneschi, B W J H Penninx
BACKGROUND: Depressive and anxiety disorders are associated with shorter leukocyte telomere length (LTL), an indicator of cellular aging. It is, however, unknown which pathways underlie this association. This study examined the extent to which lifestyle factors and physiological changes such as inflammatory or metabolic alterations mediate the relationship. METHOD: We applied mediation analysis techniques to data from 2750 participants of the Netherlands Study of Depression and Anxiety...
August 2016: Psychological Medicine
Jue Lin, Joshua Cheon, Rashida Brown, Michael Coccia, Eli Puterman, Kirstin Aschbacher, Elizabeth Sinclair, Elissa Epel, Elizabeth H Blackburn
Telomeres, the protective DNA-protein complexes at the ends of linear chromosomes, are important for genome stability. Leukocyte or peripheral blood mononuclear cell (PBMC) telomere length is a potential biomarker for human aging that integrates genetic, environmental, and lifestyle factors and is associated with mortality and risks for major diseases. However, only a limited number of studies have examined longitudinal changes of telomere length and few have reported data on sorted circulating immune cells...
2016: Journal of Immunology Research
Josine E Verhoeven, Patricia van Oppen, Dóra Révész, Owen M Wolkowitz, Brenda W J H Penninx
OBJECTIVE: Several cross-sectional studies have related depressive and anxiety disorders to shorter leukocyte telomere length (LTL) as an indicator of cellular aging. However, these studies have left many unresolved questions about underlying causality and ordering of associations. The objective of the present large, longitudinal study was to examine the relationship between depressive and anxiety disorders and LTL over a 6-year time period. METHOD: Data are from the Netherlands Study of Depression and Anxiety, including 2,292 patients with remitted and current diagnoses of depressive or anxiety disorders and 644 healthy control subjects...
June 1, 2016: American Journal of Psychiatry
Dóra Révész, Yuri Milaneschi, Erik M Terpstra, Brenda W J H Penninx
BACKGROUND: Short leukocyte telomere length (TL) and accelerated telomere attrition have been associated with various deleterious health outcomes, although their determinants have not been explored collectively in a large-scale study. MATERIAL AND METHODS: Leukocyte TL was measured (baseline N=2936; 6-year follow-up N=1860) in participants (18-65 years) from the NESDA study. Baseline determinants of TL included sociodemographics, lifestyle, chronic diseases, psychosocial stressors, and metabolic and physiological stress markers...
May 2016: Psychoneuroendocrinology
Stefan Enroth, Sofia Bosdotter Enroth, Åsa Johansson, Ulf Gyllensten
Ageing is linked to a number of changes in how the body and its organs function. On a molecular level, ageing is associated with a reduction of telomere length, changes in metabolic and gene-transcription profiles and an altered DNA-methylation pattern. Lifestyle factors such as smoking or stress can impact some of these molecular processes and thereby affect the ageing of an individual. Here we demonstrate by analysis of 77 plasma proteins in 976 individuals, that the abundance of circulating proteins accurately predicts chronological age, as well as anthropometrical measurements such as weight, height and hip circumference...
2015: Scientific Reports
Dóra Révész, Yuri Milaneschi, Josine E Verhoeven, Jue Lin, Brenda W J H Penninx
CONTEXT: Deterioration of metabolic syndrome (MetS) has been associated with short telomere length (TL). Large-scale longitudinal studies with repeated measures of MetS and TL are lacking. OBJECTIVES: We examined whether baseline MetS components predict TL over time, and whether deteriorations in MetS parallel telomere attrition. DESIGN AND SETTING: Participants were part of The Netherlands Study of Depression and Anxiety, an ongoing prospective cohort study...
August 2015: Journal of Clinical Endocrinology and Metabolism
J J Soler, C Ruiz Castellano, J Martínez-de la Puente, G Tomás, M Ruiz-Rodríguez, J Figuerola
Although little is known on the impact of environment on telomere length dynamics, it has been suggested to be affected by stress, lifestyle and/or life-history strategies of animals. We here compared telomere dynamics in erythrocytes of hatchlings and fledglings of the brood parasite great spotted cuckoos (Clamator glandarius) and of magpies (Pica pica), their main host in Europe. In magpie chicks, telomere length decreased from hatching to fledging, whereas no significant change in telomere length of great spotted cuckoo chicks was found...
September 2015: Journal of Evolutionary Biology
S Toupance, G Watfa, C Lakomy, A Kearney-Schwartz, C Labat, P Rossignol, P Lacolley, F Zannad, A Benetos
OBJECTIVE: Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival in the elderly. The prevailing view is that LTL is associated with accelerated aging since it serves as a biomarker of the cumulative burden of inflammation and oxidative stress during adult life. However LTL dynamics are mainly defined by LTL at birth, which is highly variable, and its age-dependent attrition thereafter, which is rapid during the first 20 years of life...
June 2015: Journal of Hypertension
Wong-Ho Chow, Matthew Chrisman, Carrie R Daniel, Yuanqing Ye, Henry Gomez, Qiong Dong, Chelsea E Anderson, Shine Chang, Sara Strom, Hua Zhao, Xifeng Wu
Hispanic Americans comprise the largest and fastest-growing ethnic minority in the USA. In Houston, Texas, 44% of the population is of Hispanic descent, with the majority being Mexican Americans (78%). This population is under-represented in health-related research despite their high prevalence of obesity and diabetes, which may predispose them to cancer and other chronic conditions. Recognizing the need for a greater research effort into the health risks of Hispanic Americans, the population-based Mexican American (Mano a Mano) Cohort study was launched in 2001...
April 1, 2017: International Journal of Epidemiology
Sonia García-Calzón, Miguel A Martínez-González, Cristina Razquin, Dolores Corella, Jordi Salas-Salvadó, J Alfredo Martínez, Guillermo Zalba, Amelia Marti
BACKGROUND: The gene variant Pro/Ala (rs1801282) in the PPARγ2 has been associated with lower cardiovascular risk and greater benefit from lifestyle interventions. This polymorphism also seems to be associated with longer lifespan, but no information on telomere length (TL) is available. Our aim was to study the association between the Ala allele and changes in TL in high cardiovascular risk subjects and the potential interaction with a Mediterranean dietary pattern. METHODS AND RESULTS: A total of 521 subjects (55-80 years) participating in the Prevención con Dieta Mediterránea randomized trial were genotyped...
February 2015: Circulation. Cardiovascular Genetics
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