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https://www.readbyqxmd.com/read/28488058/-evaluating-the-maturity-of-it-supported-clinical-imaging-and-diagnosis-using-the-digital-imaging-adoption-model-are-your-clinical-imaging-processes-ready-for-the-digital-era
#1
REVIEW
J Studzinski
The Digital Imaging Adoption Model (DIAM) has been jointly developed by HIMSS Analytics and the European Society of Radiology (ESR). It helps evaluate the maturity of IT-supported processes in medical imaging, particularly in radiology. This eight-stage maturity model drives your organisational, strategic and tactical alignment towards imaging-IT planning. The key audience for the model comprises hospitals with imaging centers, as well as external imaging centers that collaborate with hospitals. The assessment focuses on different dimensions relevant to digital imaging, such as software infrastructure and usage, workflow security, clinical documentation and decision support, data exchange and analytical capabilities...
May 9, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28483546/impact-of-a-structured-report-template-on-the-quality-of-ct-and-mri-reports-for-hepatocellular-carcinoma-diagnosis
#2
Milana Flusberg, Jeremy Ganeles, Tulay Ekinci, Shlomit Goldberg-Stein, Viktoriya Paroder, Mariya Kobi, Victoria Chernyak
PURPOSE: To assess the impact of a Liver Imaging Reporting and Data System (LI-RADS) structured template on quality of reports for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A departmental structured LI-RADS template was adopted in April 2015. CT and MRI reports from September 2014 to February 2016 with probable or definite HCC were reviewed. Reporting of the following was recorded for each lesion and compared between template and free-text reports: (1) LI-RADS category, (2) Couinaud segment, and (3) unequivocal description of presence or absence of major LI-RADS HCC features: arterial phase hyperenhancement, "washout," diameter, threshold growth, and "capsule...
May 5, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28474819/towards-a-standard-for-the-evaluation-of-pet-auto-segmentation-methods-requirements-and-implementation
#3
Beatrice Berthon, Emiliano Spezi, Paulina Galavis, Tony Shepherd, Aditya Apte, Mathieu Hatt, Hadi Fayad, Elisabetta De Bernardi, Chiara Soffientini, Charles R Schmidtlein, Issam El Naqa, Robert Jeraj, Wei Lu, Shiva Das, Habib Zaidi, Osama R Mawlawi, Dimitris Visvikis, John A Lee, Assen S Kirov
PURPOSE: The aim of this paper is to define the requirements and describe the design and implementation of a standard benchmark tool for evaluation and validation of PET-auto-segmentation (PET-AS) algorithms. This work follows the recommendations of Task Group 211 (TG211) appointed by the American Association of Physicists in Medicine (AAPM). METHODS: The recommendations published in the AAPM TG211 report were used to derive a set of required features and to guide the design and structure of a benchmarking software tool...
May 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/28468048/-papillary-renal-carcinoma-with-glomerular-structures-report-of-a-case
#4
Y J Hu, J G Wang, J J Guan, F J Xin, W Zhang
No abstract text is available yet for this article.
May 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28427102/an-intramolecular-car-h%C3%A2-%C3%A2-%C3%A2-o-c-hydrogen-bond-and-the-configuration-of-rotenoids
#5
Yulin Ren, Judith C Gallucci, A Douglas Kinghorn
Over the past half a century, the structure and configuration of the rotenoids, a group of natural products showing multiple promising bioactivities, have been established by interpretation of their NMR and electronic circular dichroism spectra and confirmed by analysis of single-crystal X-ray diffraction data. The chemical shift of the H-6' (1)H NMR resonance has been found to be an indicator of either a cis or trans C/D ring system. In the present study, four structures representing the central rings of a cis-, a trans-, a dehydro-, and an oxadehydro-rotenoid have been plotted using the Mercury program based on X-ray crystal structures reported previously, with the conformations of the C/D ring system, the local bond lengths or interatomic distances, hydrogen bond angles, and the H-6' chemical shift of these compounds presented...
April 20, 2017: Planta Medica
https://www.readbyqxmd.com/read/28396597/photoreceptor-outer-segment-like-structures-in-long-term-3d-retinas-from-human-pluripotent-stem-cells
#6
Karl J Wahlin, Julien A Maruotti, Srinivasa R Sripathi, John Ball, Juan M Angueyra, Catherine Kim, Rhonda Grebe, Wei Li, Bryan W Jones, Donald J Zack
The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could offer a means to study human retinal development, provide a platform to investigate the mechanisms of retinal degeneration and screen for neuroprotective compounds, and provide the basis for cell-based therapeutic strategies. In this study, we describe an in vitro method by which hPSCs can be differentiated into 3D retinas with at least some important features reminiscent of a mature retina, including exuberant outgrowth of outer segment-like structures and synaptic ribbons, photoreceptor neurotransmitter expression, and membrane conductances and synaptic vesicle release properties consistent with possible photoreceptor synaptic function...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28393301/structured-reporting-of-ct%C3%A2-enterography%C3%A2-for%C3%A2-inflammatory-bowel-disease-effect-on-key-feature%C3%A2-reporting-accuracy-across-training-levels-and-subjective-assessment-of-disease-by-referring-physicians
#7
Benjamin Wildman-Tobriner, Brian C Allen, Mustafa R Bashir, Morgan Camp, Chad Miller, Lauren E Fiorillo, Alan Cubre, Sanaz Javadi, Alex D Bibbey, Wendy L Ehieli, Nancy McGreal, Reinaldo Quevedo, Julie K Thacker, Maciej Mazurowski, Tracy A Jaffe
PURPOSE: To compare the content and accuracy of structured reporting (SR) versus non-structured reporting (NSR) for computed tomographic enterography (CTE) of inflammatory bowel disease (IBD). MATERIALS AND METHODS: This IRB-approved, HIPAA-compliant, retrospective study included 30 adult subjects (15 male, 15 female; mean age 41.9 years) with IBD imaged with CTE. Nine radiologists (3 faculty, 3 abdominal imaging fellows, and 3 senior radiology residents) independently interpreted all examinations using both NSR and SR, separated by four weeks...
April 9, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28387401/chemical-grafting-of-co9s8-onto-c60-for-hydrogen-spillover-and-storage
#8
Lu Han, Wei Qin, Jia Zhou, Jiahuang Jian, Songtao Lu, Xiaohong Wu, Guohua Fan, Peng Gao, Boyu Liu
Metal modified C60 is considered to be a potential hydrogen storage medium due to its high theoretical capacity. Research interest is growing in various hybrid inorganic compounds-C60. While the design and synthesis of a novel hybrid inorganic compound-C60 is difficult to attain, it has been theorized that the atomic hydrogen could transfer from the inorganic compound to the adjacent C60 surfaces via spillover and surface diffusion. Here, as a proof of concept experiment, we graft Co9S8 onto C60via a facile high energy ball milling process...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28368281/crystal-structure-of-a-small-heat-shock-protein-from-xylella-fastidiosa-reveals-a-distinct-high-order-structure
#9
Emanuella Maria Barreto Fonseca, Valéria Scorsato, Marcelo Leite Dos Santos, Atilio Tomazini Júnior, Susely Ferraz Siqueira Tada, Clelton Aparecido Dos Santos, Marcelo Augusto Szymanski de Toledo, Anete Pereira de Souza, Igor Polikarpov, Ricardo Aparicio
Citrus variegated chlorosis is a disease that attacks economically important citrus plantations and is caused by the plant-pathogenic bacterium Xylella fastidiosa. In this work, the structure of a small heat-shock protein from X. fastidiosa (XfsHSP17.9) is reported. The high-order structures of small heat-shock proteins from other organisms are arranged in the forms of double-disc, hollow-sphere or spherical assemblies. Unexpectedly, the structure reported here reveals a high-order architecture forming a nearly square cavity...
April 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28357589/use-of-a-web-based-calculator-and-a-structured-report-generator-to-improve-efficiency-accuracy-and-consistency-of-radiology-reporting
#10
Alexander J Towbin, C Matthew Hawkins
While medical calculators are common, they are infrequently used in the day-to-day radiology practice. We hypothesized that a calculator coupled with a structured report generator would decrease the time required to interpret and dictate a study in addition to decreasing the number of errors in interpretation. A web-based application was created to help radiologists calculate leg-length discrepancies. A time motion study was performed to evaluate if the calculator helped to decrease the time for interpretation and dictation of leg-length radiographs...
March 29, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28340354/mechanism-of-substrate-translocation-in-an-alternating-access-transporter
#11
Naomi R Latorraca, Nathan M Fastman, A J Venkatakrishnan, Wolf B Frommer, Ron O Dror, Liang Feng
Transporters shuttle molecules across cell membranes by alternating among distinct conformational states. Fundamental questions remain about how transporters transition between states and how such structural rearrangements regulate substrate translocation. Here, we capture the translocation process by crystallography and unguided molecular dynamics simulations, providing an atomic-level description of alternating access transport. Simulations of a SWEET-family transporter initiated from an outward-open, glucose-bound structure reported here spontaneously adopt occluded and inward-open conformations...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28326148/patient-safety-learning-systems-a-systematic-review-and-qualitative-synthesis
#12
(no author information available yet)
BACKGROUND: A patient safety learning system (sometimes called a critical incident reporting system) refers to structured reporting, collation, and analysis of critical incidents. To inform a provincial working group's recommendations for an Ontario Patient Safety Event Learning System, a systematic review was undertaken to determine design features that would optimize its adoption into the health care system and would inform implementation strategies. METHODS: The objective of this review was to address two research questions: (a) what are the barriers to and facilitators of successful adoption of a patient safety learning system reported by health professionals and (b) what design components maximize successful adoption and implementation? To answer the first question, we used a published systematic review...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28323635/magnetic-states-of-mnp-muon-spin-rotation-studies
#13
R Khasanov, A Amato, P Bonfà, Z Guguchia, H Luetkens, E Morenzoni, R De Renzi, N D Zhigadlo
Muon-spin rotation data collected at ambient pressure (p) and at p  =  2.42 GPa in MnP were analyzed to check their consistency with various low- and high-pressure magnetic structures reported in the literature. Our analysis confirms that in MnP the low-temperature and low-pressure helimagnetic phase is characterised by an increased value of the average magnetic moment compared to the high-temperature ferromagnetic phase. An elliptical double-helical structure with a propagation vector [Formula: see text], an a-axis moment elongated by approximately 18% and an additional tilt of the rotation plane towards c-direction by [Formula: see text]-8° leads to a good agreement between the theory and the experiment...
April 26, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28322271/mechanistic-and-structural-basis-of-bioengineered-bovine-cathelicidin-5-with-optimized-therapeutic-activity
#14
Bikash R Sahoo, Kenta Maruyama, Jyotheeswara R Edula, Takahiro Tougan, Yuxi Lin, Young-Ho Lee, Toshihiro Horii, Toshimichi Fujiwara
Peptide-drug discovery using host-defense peptides becomes promising against antibiotic-resistant pathogens and cancer cells. Here, we customized the therapeutic activity of bovine cathelicidin-5 targeting to bacteria, protozoa, and tumor cells. The membrane dependent conformational adaptability and plasticity of cathelicidin-5 is revealed by biophysical analysis and atomistic simulations over 200 μs in thymocytes, leukemia, and E. coli cell-membranes. Our understanding of energy-dependent cathelicidin-5 intrusion in heterogeneous membranes aided in designing novel loss/gain-of-function analogues...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295332/crystalline-phases-found-in-rapidly-quenched-ni-nb-zr-alloys
#15
L P Deo, M J Kaufman, B Wang, S Nikodemski, M F DE Oliveira
The properties of metallic alloys can be significantly improved by developing non-equilibrium phases in the microstructures through rapid solidification techniques, thus the characterisation of these unusual structures is extremely important. In this research, the microstructures of three rapidly quenched alloys, namely Ni65.2 Nb33.8 Zr1.0 , Ni54.8 Nb31.1 Zr14.1 and Ni54.8 Nb21.6 Zr23.6 (at. %) were investigated in greater detail in order to determine the structures and compositions of their crystalline phases...
March 15, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28289942/structured-reporting-of-mri-of-the-shoulder-improvement-of-report-quality
#16
Sebastian Gassenmaier, Marco Armbruster, Florian Haasters, Tobias Helfen, Thomas Henzler, Sedat Alibek, Dominik Pförringer, Wieland H Sommer, Nora N Sommer
OBJECTIVES: To evaluate the effect of structured reports (SRs) in comparison to non-structured narrative free text (NRs) shoulder MRI reports and potential effects of both types of reporting on completeness, readability, linguistic quality and referring surgeons' satisfaction. METHODS: Thirty patients after trauma or with suspected degenerative changes of the shoulder were included in this study (2012-2015). All patients underwent shoulder MRI for further assessment and possible surgical planning...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28259629/structured-reporting-of-ct-examinations-in-acute-pulmonary-embolism
#17
Bastian O Sabel, Jessica L Plum, Nikolaus Kneidinger, Gabriela Leuschner, Leandra Koletzko, Bijan Raziorrouh, Regina Schinner, Wolfgang G Kunz, Franziska Schoeppe, Kolja M Thierfelder, Wieland H Sommer, Felix G Meinel
OBJECTIVES: To evaluate the effect of structured reporting of CT pulmonary angiography (CTPA) studies on the content, clarity and clinical usefulness of radiology reports in acute pulmonary embolism (PE). METHODS: Conventional and structured reports were generated for 41 patients with a CTPA positive for acute PE. Conventional reports were dictated in a free-text form using speech recognition; structured reports contained a consistent ordering of observations with standardized subheadings...
February 22, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28220929/increasing-the-efficiency-on-producing-radiology-reports-for-breast-cancer-diagnosis-by-means-of-structured-reports-a-comparative-study
#18
J Damian Segrelles, Rosana Medina, Ignacio Blanquer, Luis Martí-Bonmatí
BACKGROUND: Radiology reports are commonly written on free-text using voice recognition devices. Structured reports (SR) have a high potential but they are usually considered more difficult to fill-in so their adoption in clinical practice leads to a lower efficiency. However, some studies have demonstrated that in some cases, producing SRs may require shorter time than plain-text ones. This work focuses on the definition and demonstration of a methodology to evaluate the productivity of software tools for producing radiology reports...
February 21, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28190870/the-complexity-of-glycoprotein-derived-glycans
#19
REVIEW
Johannes F G Vliegenthart
A brief review is presented of our studies on the structure of glycoprotein-derived glycans. The emphasis is on the introduction of high-resolution (1)H-NMR spectroscopy for the unambiguous determination of primary structures. For this purpose, we developed the structural reporter group concept. Structural reporters are defined as unique markers of structural elements in the NMR spectra. Application of this concept led to the discovery of numerous new structures. Furthermore, a number of structures presented in the literature could be corrected...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/28188295/myroilysin-is-a-new-bacterial-member-of-the-m12a-family-of-metzincin-metallopeptidases-and-is-activated-by-a-cysteine-switch-mechanism
#20
Dongqing Xu, Jiale Zhou, Xiangdi Lou, Jianhua He, Tingting Ran, Weiwu Wang
Proteases play important roles in all living organisms and also have important industrial applications. Family M12A metalloproteases, mainly found throughout the animal kingdom, belong to the metzincin protease family and are synthesized as inactive precursors. So far, only flavastacin and myroilysin, isolated from bacteria, were reported to be M12A proteases, whereas the classification of myroilysin is still unclear due to the lack of structural information. Here, we report the crystal structures of pro-myroilysin from bacterium Myroides sp...
March 31, 2017: Journal of Biological Chemistry
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