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https://www.readbyqxmd.com/read/29326162/structural-basis-for-p-ppgpp-synthesis-by-the-staphylococcus-aureus-small-alarmone-synthetase-relp
#1
Melek Cemre Manav, Jelena Beljantseva, Martin Saxtorph Bojer, Tanel Tenson, Hanne Ingmer, Vasili Hauryliuk, Ditlev Egeskov Brodersen
The stringent response is a global reprogramming of bacterial physiology that renders cells more tolerant to antibiotics and induces virulence gene expression in pathogens in response to stress. This process is driven by accumulation of the intracellular alarmone guanosine-5'-di(tri)phosphate-3'-diphosphate ([p]ppGpp), which is produced by enzymes of the RelA SpoT homologue (RSH) family. The Gram-positive Firmicute pathogen, Staphylococcus aureus, encodes three RSH enzymes: a multi-domain RSH (Rel) that senses amino acid starvation on the ribosome and two small alarmone synthetase (SAS) enzymes, RelQ (SAS1) and RelP (SAS2)...
January 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29318533/chemical-shift-assignments-of-chu_1110-an-ahsa1-like-protein-from-cytophaga-hutchinsonii
#2
Chunjie Liang, Ting He, Tao Li, Yunhuang Yang, Jiang Zhu, Maili Liu
AHSA1 protein family is one of the four largest families in the Bet v1-like protein superfamily. The functions and structures of proteins in AHSA1 family are still largely unknown. CHU_1110 with 167 amino acids and a molecular weight of 19.2 kDa is a member of the AHSA1 family from Cytophaga hutchinsonii, a soil bacterium known for its ability to digest crystalline cellulose. Here we report the complete 1H, 13C and 15N chemical shift assignments of CHU_1110. The secondary structural elements of CGL2373 are consistent with the canonical AHSA1 structure...
January 9, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29314058/impact-of-using-scatter-mimicking-beams-instead-of-standard-beams-to-measure-penetration-when-assessing-the-protective-value-of-radiation-protective-garments
#3
A Kyle Jones, Alexander S Pasciak, Louis K Wagner
PURPOSE: Use standardized methods to determine how assessment of protective value of radiation-protective garments changes under conditions employing standard beam qualities, scatter-mimicking primary beams, and a modified Hp (10) measurement. METHODS: The shielding properties of radiation-protective garments depend on the spectrum of beam energies striking the garment and the attenuation properties of materials used to construct the garment, including X-ray fluorescence produced by these materials...
January 3, 2018: Medical Physics
https://www.readbyqxmd.com/read/29295773/a-comprehensive-approach-to-convert-a-radiology-department-from-coding-based-on-international-classification-of-diseases-ninth-revision-to-coding-based-on-international-classification-of-diseases-tenth-revision
#4
Morgan P McBee, Tal Laor, Rebecca M Pryor, Rachel Smith, Judy Hardin, Lisa Ulland, Sally May, Bin Zhang, Alexander J Towbin
PURPOSE: The purpose of this study was to adapt our radiology reports to provide the documentation required for specific International Classification of Diseases, tenth rev (ICD-10) diagnosis coding. MATERIALS AND METHODS: Baseline data were analyzed to identify the reports with the greatest number of unspecified ICD-10 codes assigned by computer-assisted coding software. A two-part quality improvement initiative was subsequently implemented. The first component involved improving clinical histories by utilizing technologists to obtain information directly from the patients or caregivers, which was then imported into the radiologist's report within the speech recognition software...
December 30, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29286636/topology-of-intermetallic-structures-from-statistics-to-rational-design
#5
Tatiana G Akhmetshina, Vladislav A Blatov, Davide M Proserpio, Alexander P Shevchenko
More than 38 000 substances made only of metal atoms are collected in modern structural databases; we may call them intermetallic compounds. They have important industrial applications, and yet they are terra incognita for most of our undergraduate students. Their structural complexity and synthesis are not easily adaptable to first years laboratories, keeping them away from the standard curricula. They have been described over the years following alternative and complementary views such as coordination polyhedra, atomic layers, and polyatomic clusters...
December 29, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29277858/multi-institutional-survey-on-imaging-practice-patterns-in-pancreatic-ductal-adenocarcinoma
#6
Avinash R Kambadakone, Atif Zaheer, Ott Le, Priya Bhosale, Jeffrey Meier, Alexander R Guimaraes, Zarine Shah, David M Hough, Lorenzo Mannelli, Erik Soloff, Arnold Friedman, Eric Tamm
PURPOSE: To study the practice patterns for performance and interpretation of CT/MRI imaging studies in patients with pancreatic ductal adenocarcinoma (PDAC) at multiple institutions using a survey-based assessment. METHODS: In this study, abdominal radiologists/body imagers on the Society of Abdominal Radiology disease-focused panel for PDAC and from multiple institutions participated in an online survey. The survey was designed to investigate the imaging and reporting practice patterns for PDAC...
December 26, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29247353/structured-vs-narrative-reporting-of-pelvic-mri-for-fibroids-clarity-and-impact-on-treatment-planning
#7
Andrea Franconeri, Jieming Fang, Benjamin Carney, Almamoon Justaniah, Laura Miller, Hye-Chun Hur, Louise P King, Roa Alammari, Salomao Faintuch, Koenraad J Mortele, Olga R Brook
OBJECTIVES: To evaluate clarity and usefulness of MRI reporting of uterine fibroids using a structured disease-specific template vs. narrative reporting for planning of fibroid treatment by gynaecologists and interventional radiologists. METHODS: This is a HIPAA-compliant, IRB-approved study with waiver of informed consent. A structured reporting template for fibroid MRIs was developed in collaboration between gynaecologists, interventional and diagnostic radiologists...
December 15, 2017: European Radiology
https://www.readbyqxmd.com/read/29239122/crystal-structure-of-native-%C3%AE-n-acetylhexosaminidase-isolated-from-aspergillus-oryzae-sheds-light-onto-its-substrate-specificity-high-stability-and-regulation-by-propeptide
#8
Jana Škerlová, Jan Bláha, Petr Pachl, Kateřina Hofbauerová, Zdeněk Kukačka, Petr Man, Petr Pompach, Petr Novák, Zbyszek Otwinowski, Jiří Brynda, Ondřej Vaněk, Pavlína Řezáčová
β-N-acetylhexosaminidase from the fungus Aspergillus oryzae is a secreted extracellular enzyme that cleaves chitobiose into constituent monosaccharides. It belongs to the GH 20 glycoside hydrolase family and consists of two N-glycosylated catalytic cores noncovalently associated with two 10-kDa O-glycosylated propeptides. We used X-ray diffraction and mass spectrometry to determine the structure of Aspergillus oryzae β-N-acetylhexosaminidase isolated from its natural source. The three-dimensional structure determined and refined to a resolution of 2...
December 14, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29230680/structured-reporting-for-fibrosing-lung-disease-a-model-shared-by-radiologist-and-pulmonologist
#9
Nicola Sverzellati, Anna Odone, Mario Silva, Roberta Polverosi, Carlo Florio, Luciano Cardinale, Giancarlo Cortese, Giancarlo Addonisio, Maurizio Zompatori, Giorgia Dalpiaz, Sara Piciucchi, Anna Rita Larici
OBJECTIVES: To apply the Delphi exercise with iterative involvement of radiologists and pulmonologists with the aim of defining a structured reporting template for high-resolution computed tomography (HRCT) of patients with fibrosing lung disease (FLD). METHODS: The writing committee selected the HRCT criteria-the Delphi items-for rating from both radiology panelists (RP) and pulmonology panelists (PP). The Delphi items were first rated by RPs as "essential", "optional", or "not relevant"...
December 11, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29221286/automatic-lung-rads%C3%A2-classification-with-a-natural-language-processing-system
#10
Sebastian E Beyer, Brady J McKee, Shawn M Regis, Andrea B McKee, Sebastian Flacke, Gilan El Saadawi, Christoph Wald
Background: Our aim was to train a natural language processing (NLP) algorithm to capture imaging characteristics of lung nodules reported in a structured CT report and suggest the applicable Lung-RADS™ (LR) category. Methods: Our study included structured, clinical reports of consecutive CT lung screening (CTLS) exams performed from 08/2014 to 08/2015 at an ACR accredited Lung Cancer Screening Center. All patients screened were at high-risk for lung cancer according to the NCCN Guidelines®...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29202260/interobserver-agreement-for-post-mortem-renal-histopathology-and-diagnosis-of-acute-tubular-necrosis-in-critically-ill-patients
#11
MULTICENTER STUDY
Neil J Glassford, Alison Skene, Maria B Guardiola, Matthew J Chan, Sean M Bagshaw, Rinaldo Bellomo, Kim Solez
BACKGROUND: The renal histopathology of critically ill patients dying with acute kidney injury (AKI) in intensive care units of high income countries remains uncertain. METHODS: Retrospective observational assessment of interobserver agreement in the reporting of renal post mortem histopathology, and the ability of pathologists blinded to the clinical context to independently identify the presence of pre-mortem AKI from digital images of histological sections from 34 critically ill patients dying in teaching hospitals in Australia and Canada...
December 2017: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/29189048/recall-of-structured-radiology-reports-is-significantly-superior-to-that-of-unstructured-reports
#12
Bryan W Buckley, Leslie Daly, Grainne N Allen, Carole A Ridge
OBJECTIVE: To measure recall of structured compared to unstructured radiology reports. METHODS: Institutional review board approval was obtained. Four hypothetical radiology reports, two structured and two unstructured, were created for the purposes of this study by an experienced consultant radiologist. The reports, each followed immediately by a multiple-choice questionnaire listing possible diagnoses from the report, were distributed to the members of two national physician associations using a web-based survey tool...
November 30, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29188759/identifying-free-text-features-to-improve-automated-classification-of-structured-histopathology-reports-for-feline-small-intestinal-disease
#13
Abdullah Awaysheh, Jeffrey Wilcke, François Elvinger, Loren Rees, Weiguo Fan, Kurt Zimmerman
The histologic evaluation of gastrointestinal (GI) biopsies is the standard for diagnosis of a variety of GI diseases (e.g., inflammatory bowel disease [IBD] and alimentary lymphoma [ALA]). The World Small Animal Veterinary Association (WSAVA) Gastrointestinal International Standardization Group proposed a reporting standard for GI biopsies consisting of a defined set of microscopic features. We compared the machine classification accuracy of free-text microscopic findings with those represented in the WSAVA format with a diagnosis of IBD and ALA...
November 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29168005/a-survey-by-the-european-society-of-breast-imaging-on-the-utilisation-of-breast-mri-in-clinical-practice
#14
Paola Clauser, Ritse Mann, Alexandra Athanasiou, Helmut Prosch, Katja Pinker, Matthias Dietzel, Thomas H Helbich, Michael Fuchsjäger, Julia Camps-Herrero, Francesco Sardanelli, Gabor Forrai, Pascal A T Baltzer
OBJECTIVES: While magnetic resonance imaging (MRI) is considered a helpful diagnostic tool in breast imaging, discussions are ongoing about appropriate protocols and indications. The European Society of Breast Imaging (EUSOBI) launched a survey to evaluate the utilisation of breast MRI in clinical practice. METHODS: An online survey reviewed by the EUSOBI board and committees was distributed amongst members. The questions encompassed: training and experience; annual breast MRI and MRI-guided-intervention workload; examination protocols; indications; reporting habits and preferences...
November 22, 2017: European Radiology
https://www.readbyqxmd.com/read/29157316/evaluation-of-the-hta-core-model-for-national-health-technology-assessment-reports-comparative-study-and-experiences-from-european-countries
#15
Kristina Kõrge, Nadine Berndt, Juergen Hohmann, Florence Romano, Mickael Hiligsmann
OBJECTIVES: The health technology assessment (HTA) Core Model® is a tool for defining and standardizing the elements of HTA analyses within several domains for producing structured reports. This study explored the parallels between the Core Model and a national HTA report. Experiences from various European HTA agencies were also investigated to determine the Core Model's adaptability to national reports. METHODS: A comparison between a national report on Genetic Counseling, produced by the Cellule d'expertise médicale Luxembourg, and the Core Model was performed to identify parallels in terms of relevant and comparable assessment elements (AEs)...
November 21, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29100252/guidelines-regarding-%C3%A2-16-of-the-german-transplantation-act-initial-experiences-with-structured-reporting
#16
Daniel Pinto Dos Santos, Gordon Arnhold, Peter Mildenberger, Christoph Düber, Roman Kloeckner
Purpose To transfer the report sheet from the guidelines regarding the German Transplantation Act to a standards-compliant report template and to evaluate it in the clinical routine. Materials and Methods The template was developed using the freely available software brackets.io. It was implemented in the clinical routine using a reporting platform developed in-house. Interfaces to the department RIS and PACS allowed for integration into the usual reporting workflow. The evaluation period was 70 days. Results Developing the template for implementation of the guidelines was possible without any difficulties...
December 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29099612/diagnostic-performance-and-useful-findings-of-ultrasound-re-evaluation-for-patients-with-equivocal-ct-features-of-acute-appendicitis
#17
Mi Sung Kim, Heon-Ju Kwon, Kyung A Kang, In-Gu Do, Hee-Jin Park, Eun Young Kim, Hyun Pyo Hong, Yoon Jung Choi, Young Hwan Kim
OBJECTIVE: To evaluate the diagnostic performance of ultrasound and to determine which ultrasound findings are useful to differentiate appendicitis from non-appendicitis in patients who underwent ultrasound re-evaluation owing to equivocal CT features of acute appendicitis. METHODS: 62 patients who underwent CT examinations for suspected appendicitis followed by ultrasound re-evaluation owing to equivocal CT findings were included. Equivocal CT findings were considered based on the presence of only one or two findings among the CT criteria, and ultrasound re-evaluation was done based on a predefined structured report form...
November 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29091009/evidence-based-reporting-a-method-to-optimize-prostate-mri-communications-with-referring-physicians
#18
Michael J Magnetta, Ashley L Donovan, Bruce L Jacobs, Benjamin J Davies, Alessandro Furlan
OBJECTIVE: The purpose of this study was to develop an evidence-based method to optimize prostate MRI reports that would improve communication between urologists and radiologists. MATERIALS AND METHODS: This quality improvement initiative was approved by the institutional Quality Improvement Review Committee. A structured report was developed containing essential components defined by local practice norms and Prostate Imaging Reporting and Data System (PI-RADS) lexicon version 2...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29079959/integrating-natural-language-processing-and-machine-learning-algorithms-to-categorize-oncologic-response-in-radiology-reports
#19
Po-Hao Chen, Hanna Zafar, Maya Galperin-Aizenberg, Tessa Cook
A significant volume of medical data remains unstructured. Natural language processing (NLP) and machine learning (ML) techniques have shown to successfully extract insights from radiology reports. However, the codependent effects of NLP and ML in this context have not been well-studied. Between April 1, 2015 and November 1, 2016, 9418 cross-sectional abdomen/pelvis CT and MR examinations containing our internal structured reporting element for cancer were separated into four categories: Progression, Stable Disease, Improvement, or No Cancer...
October 27, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29064758/a-comparison-of-radiologists-and-urologists-opinions-regarding-prostate-mri-reporting-results-from-a-survey-of-specialty-societies
#20
Benjamin Spilseth, Sangeet Ghai, Nayana U Patel, Samir S Taneja, Daniel J Margolis, Andrew B Rosenkrantz
OBJECTIVE: The purpose of this study is to compare radiologists' and urologists' opinions regarding prostate MRI reporting. SUBJECTS AND METHODS: Radiologist members of the Society of Abdominal Radiology and urologist members of the Society of Urologic Oncology received an electronic survey regarding prostate MRI reporting. RESULTS: The response rate was 12% (135/1155) for Society of Abdominal Radiology and 8% (54/663) for Society of Urologic Oncology members...
October 24, 2017: AJR. American Journal of Roentgenology
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