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https://www.readbyqxmd.com/read/28636805/a-hybrid-phantom-system-for-patient-skin-and-organ-dosimetry-in-fluoroscopically-guided-interventions
#1
David Borrego, Daniel Siragusa, Stephen Balter, Wesley E Bolch
To investigate calibrations for improved estimates of skin dose and to develop software for computing absorbed organ doses for fluoroscopically guided interventions (FGIs) with the use of radiation dose structured reports (RDSR) and the UF/NCI family of hybrid computational phantoms METHODS AND MATERIALS: Institutional review board approval was obtained for this retrospective study in which ten RDSRs were selected for their high cumulative reference air kerma values. Skin doses were computed using the University of Florida's rapid in-clinic peak skin dose algorithm (or UF-RIPSA)...
June 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28633922/quantifying-language-before-and-after-instituting-structured-ct-reports
#2
Stephany L Ross, Susan M Ascher, Alexander S Somwaru, Ross Filice
AIM: Our aim was to quantify the language in abdominopelvic CT reports before and after implementing structured reporting templates, specifically evaluating the terms normal and unremarkable. METHODS: We performed a search of our database for all CT abdomen and pelvis examinations before and after full template implementation. There were 1,753 studies included-878 "pretemplate" reports, 875 "posttemplate" reports. Pre- and posttemplate reports were analyzed for word count in preliminary report, word count in final report, number of changed words between preliminary and final report, and frequency of normal and unremarkable...
June 17, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28623291/crystal-structure-of-the-dna-binding-domain-of-myelin-gene-regulatory-factor
#3
Xiangkai Zhen, Bowen Li, Fen Hu, Shufeng Yan, Gabriele Meloni, Huiliang Li, Ning Shi
Myelin-gene Regulatory Factor (MyRF) is one of the master transcription factors controlling myelin formation and development in oligodendrocytes which is crucial for the powerful brain functions. The N-terminal of MyRF, which contains a proline-rich region and a DNA binding domain (DBD), is auto-cleaved from the ER membrane, and then enters the nucleus to participate in transcription regulation of the myelin genes. Here we report the crystal structure of MyRF DBD. It shows an Ig-fold like architecture which consists of two antiparallel β-sheets with 7 main strands, packing against each other, forming a β-sandwich...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28621933/structural-flexibility-of-an-inhibitor-overcomes-drug-resistance-mutations-in-staphylococcus-aureus-ftsz
#4
Junso Fujita, Yoko Maeda, Eiichi Mizohata, Tsuyoshi Inoue, Malvika Kaul, Ajit K Parhi, Edmond J LaVoie, Daniel S Pilch, Hiroyoshi Matsumura
In the effort to combat antibiotic resistance, inhibitors of the essential bacterial protein FtsZ have emerged as a promising new class of compounds with clinical potential. One such FtsZ inhibitor (TXA707) is associated with potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) that are resistant to current standard-of-care antibiotics. However, mutations in S. aureus FtsZ (SaFtsZ) that confer resistance to TXA707 have been observed, with mutations in the Gly196 and Gly193 residues being among the most prevalent...
June 16, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28609622/combined-electron-diffraction-and-spectroscopic-determination-of-the-structure-of-spiropentane-c5h8
#5
Jason W Sandwisch, Blake A Erickson, Kenneth Hedberg, Joseph W Nibler
Gas-phase electron-diffraction (GED) data have been combined with recent spectroscopic rotational constants to determine the rα(0) structural parameters for spiropentane, C5H8. The structure has D2d symmetry, and the results yield values of 1.105(2) Å for the CH bond length, 1.557(3) Å for the distal CC bond length, and a smaller value of 1.482(1) Å for the four lateral CC bonds that connect to the central carbon atom. The HCH angle is 113.7(13)°, and the HCH flap angle, defined as the angle of the HCH bisector and the distal CC bond, is 150...
June 26, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28584051/ion-pulling-simulations-provide-insights-into-the-mechanisms-of-channel-opening-of-the-skeletal-muscle-ryanodine-receptor
#6
David D Mowrey, Le Xu, Yingwu Mei, Daniel A Pasek, Gerhard Meissner, Nikolay V Dokholyan
The type 1 ryanodine receptor (RyR1) mediates Ca(2+) release from the sarcoplasmic reticulum to initiate skeletal muscle contraction and is associated with muscle diseases, malignant hyperthermia, and central core disease. To better understand RyR1 channel function, we investigated the molecular mechanisms of channel gating and ion permeation. An adequate model of channel gating requires accurate, high-resolution models of both open and closed states of the channel. To this end, we generated an open-channel RyR1 model using molecular simulations to pull Ca(2+) through the pore constriction site of a closed-channel RyR1 structure determined at 3...
June 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28580925/crystal-structure-of-the-multiple-antibiotic-resistance-regulator-marr-from-clostridium-difficile
#7
J W Peng, H Yuan, X S Tan
Regulators of multiple antibiotic resistance (MarRs) are key players against toxins in prokaryotes. MarR homologues have been identified in many bacterial and archaeal species which pose daunting antibiotic resistance issues that threaten public health. The continuous prevalence of Clostridium difficile infection (CDI) throughout the world is associated with the abuse of antibiotics, and antibiotic treatments of CDI have limited effect. In the genome of C. difficile strain 630, the marR gene (ID 4913953) encodes a MarR protein...
June 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28569075/on-the-link-between-emotionally-driven-impulsivity-and-aggression-evidence-from-a-validation-study-on-the-dutch-upps-p
#8
A M C Bousardt, E O Noorthoorn, A W Hoogendoorn, H L I Nijman, J W Hummelen
The UPPS-P seems to be a promising instrument for measuring different domains of impulsivity in forensic psychiatric patients. Validation studies of the instrument however, have been conducted only in student groups. In this validation study, three groups completed the Dutch UPPS-P: healthy student ( N = 94) and community ( N = 134) samples and a forensic psychiatric sample ( N = 73). The five-factor structure reported previously could only be substantiated in a confirmatory factor analysis over the combined groups but not in the subsamples...
May 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28488058/-evaluating-the-maturity-of-it-supported-clinical-imaging-and-diagnosis-using-the-digital-imaging-adoption-model-are-your-clinical-imaging-processes-ready-for-the-digital-era
#9
REVIEW
J Studzinski
The Digital Imaging Adoption Model (DIAM) has been jointly developed by HIMSS Analytics and the European Society of Radiology (ESR). It helps evaluate the maturity of IT-supported processes in medical imaging, particularly in radiology. This eight-stage maturity model drives your organisational, strategic and tactical alignment towards imaging-IT planning. The key audience for the model comprises hospitals with imaging centers, as well as external imaging centers that collaborate with hospitals. The assessment focuses on different dimensions relevant to digital imaging, such as software infrastructure and usage, workflow security, clinical documentation and decision support, data exchange and analytical capabilities...
June 2017: Der Radiologe
https://www.readbyqxmd.com/read/28483546/impact-of-a-structured-report-template-on-the-quality-of-ct-and-mri-reports-for-hepatocellular-carcinoma-diagnosis
#10
Milana Flusberg, Jeremy Ganeles, Tulay Ekinci, Shlomit Goldberg-Stein, Viktoriya Paroder, Mariya Kobi, Victoria Chernyak
PURPOSE: To assess the impact of a Liver Imaging Reporting and Data System (LI-RADS) structured template on quality of reports for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A departmental structured LI-RADS template was adopted in April 2015. CT and MRI reports from September 2014 to February 2016 with probable or definite HCC were reviewed. Reporting of the following was recorded for each lesion and compared between template and free-text reports: (1) LI-RADS category, (2) Couinaud segment, and (3) unequivocal description of presence or absence of major LI-RADS HCC features: arterial phase hyperenhancement, "washout," diameter, threshold growth, and "capsule...
May 5, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28474819/towards-a-standard-for-the-evaluation-of-pet-auto-segmentation-methods-requirements-and-implementation
#11
Beatrice Berthon, Emiliano Spezi, Paulina Galavis, Tony Shepherd, Aditya Apte, Mathieu Hatt, Hadi Fayad, Elisabetta De Bernardi, Chiara Soffientini, Charles R Schmidtlein, Issam El Naqa, Robert Jeraj, Wei Lu, Shiva Das, Habib Zaidi, Osama R Mawlawi, Dimitris Visvikis, John A Lee, Assen S Kirov
PURPOSE: The aim of this paper is to define the requirements and describe the design and implementation of a standard benchmark tool for evaluation and validation of PET-auto-segmentation (PET-AS) algorithms. This work follows the recommendations of Task Group 211 (TG211) appointed by the American Association of Physicists in Medicine (AAPM). METHODS: The recommendations published in the AAPM TG211 report were used to derive a set of required features and to guide the design and structure of a benchmarking software tool...
May 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/28468048/-papillary-renal-carcinoma-with-glomerular-structures-report-of-a-case
#12
Y J Hu, J G Wang, J J Guan, F J Xin, W Zhang
No abstract text is available yet for this article.
May 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28427102/an-intramolecular-car-h%C3%A2-%C3%A2-%C3%A2-o-c-hydrogen-bond-and-the-configuration-of-rotenoids
#13
Yulin Ren, Judith C Gallucci, A Douglas Kinghorn
Over the past half a century, the structure and configuration of the rotenoids, a group of natural products showing multiple promising bioactivities, have been established by interpretation of their NMR and electronic circular dichroism spectra and confirmed by analysis of single-crystal X-ray diffraction data. The chemical shift of the H-6' (1)H NMR resonance has been found to be an indicator of either a cis or trans C/D ring system. In the present study, four structures representing the central rings of a cis-, a trans-, a dehydro-, and an oxadehydro-rotenoid have been plotted using the Mercury program based on X-ray crystal structures reported previously, with the conformations of the C/D ring system, the local bond lengths or interatomic distances, hydrogen bond angles, and the H-6' chemical shift of these compounds presented...
April 20, 2017: Planta Medica
https://www.readbyqxmd.com/read/28396597/photoreceptor-outer-segment-like-structures-in-long-term-3d-retinas-from-human-pluripotent-stem-cells
#14
Karl J Wahlin, Julien A Maruotti, Srinivasa R Sripathi, John Ball, Juan M Angueyra, Catherine Kim, Rhonda Grebe, Wei Li, Bryan W Jones, Donald J Zack
The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could offer a means to study human retinal development, provide a platform to investigate the mechanisms of retinal degeneration and screen for neuroprotective compounds, and provide the basis for cell-based therapeutic strategies. In this study, we describe an in vitro method by which hPSCs can be differentiated into 3D retinas with at least some important features reminiscent of a mature retina, including exuberant outgrowth of outer segment-like structures and synaptic ribbons, photoreceptor neurotransmitter expression, and membrane conductances and synaptic vesicle release properties consistent with possible photoreceptor synaptic function...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28393301/structured-reporting-of-ct%C3%A2-enterography%C3%A2-for%C3%A2-inflammatory-bowel-disease-effect-on-key-feature%C3%A2-reporting-accuracy-across-training-levels-and-subjective-assessment-of-disease-by-referring-physicians
#15
Benjamin Wildman-Tobriner, Brian C Allen, Mustafa R Bashir, Morgan Camp, Chad Miller, Lauren E Fiorillo, Alan Cubre, Sanaz Javadi, Alex D Bibbey, Wendy L Ehieli, Nancy McGreal, Reinaldo Quevedo, Julie K Thacker, Maciej Mazurowski, Tracy A Jaffe
PURPOSE: To compare the content and accuracy of structured reporting (SR) versus non-structured reporting (NSR) for computed tomographic enterography (CTE) of inflammatory bowel disease (IBD). MATERIALS AND METHODS: This IRB-approved, HIPAA-compliant, retrospective study included 30 adult subjects (15 male, 15 female; mean age 41.9 years) with IBD imaged with CTE. Nine radiologists (3 faculty, 3 abdominal imaging fellows, and 3 senior radiology residents) independently interpreted all examinations using both NSR and SR, separated by four weeks...
April 9, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28387401/chemical-grafting-of-co9s8-onto-c60-for-hydrogen-spillover-and-storage
#16
Lu Han, Wei Qin, Jia Zhou, Jiahuang Jian, Songtao Lu, Xiaohong Wu, Guohua Fan, Peng Gao, Boyu Liu
Metal modified C60 is considered to be a potential hydrogen storage medium due to its high theoretical capacity. Research interest is growing in various hybrid inorganic compounds-C60. While the design and synthesis of a novel hybrid inorganic compound-C60 is difficult to attain, it has been theorized that the atomic hydrogen could transfer from the inorganic compound to the adjacent C60 surfaces via spillover and surface diffusion. Here, as a proof of concept experiment, we graft Co9S8 onto C60via a facile high energy ball milling process...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28368281/crystal-structure-of-a-small-heat-shock-protein-from-xylella-fastidiosa-reveals-a-distinct-high-order-structure
#17
Emanuella Maria Barreto Fonseca, Valéria Scorsato, Marcelo Leite Dos Santos, Atilio Tomazini Júnior, Susely Ferraz Siqueira Tada, Clelton Aparecido Dos Santos, Marcelo Augusto Szymanski de Toledo, Anete Pereira de Souza, Igor Polikarpov, Ricardo Aparicio
Citrus variegated chlorosis is a disease that attacks economically important citrus plantations and is caused by the plant-pathogenic bacterium Xylella fastidiosa. In this work, the structure of a small heat-shock protein from X. fastidiosa (XfsHSP17.9) is reported. The high-order structures of small heat-shock proteins from other organisms are arranged in the forms of double-disc, hollow-sphere or spherical assemblies. Unexpectedly, the structure reported here reveals a high-order architecture forming a nearly square cavity...
April 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28357589/use-of-a-web-based-calculator-and-a-structured-report-generator-to-improve-efficiency-accuracy-and-consistency-of-radiology-reporting
#18
Alexander J Towbin, C Matthew Hawkins
While medical calculators are common, they are infrequently used in the day-to-day radiology practice. We hypothesized that a calculator coupled with a structured report generator would decrease the time required to interpret and dictate a study in addition to decreasing the number of errors in interpretation. A web-based application was created to help radiologists calculate leg-length discrepancies. A time motion study was performed to evaluate if the calculator helped to decrease the time for interpretation and dictation of leg-length radiographs...
March 29, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28340354/mechanism-of-substrate-translocation-in-an-alternating-access-transporter
#19
Naomi R Latorraca, Nathan M Fastman, A J Venkatakrishnan, Wolf B Frommer, Ron O Dror, Liang Feng
Transporters shuttle molecules across cell membranes by alternating among distinct conformational states. Fundamental questions remain about how transporters transition between states and how such structural rearrangements regulate substrate translocation. Here, we capture the translocation process by crystallography and unguided molecular dynamics simulations, providing an atomic-level description of alternating access transport. Simulations of a SWEET-family transporter initiated from an outward-open, glucose-bound structure reported here spontaneously adopt occluded and inward-open conformations...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28326148/patient-safety-learning-systems-a-systematic-review-and-qualitative-synthesis
#20
REVIEW
(no author information available yet)
BACKGROUND: A patient safety learning system (sometimes called a critical incident reporting system) refers to structured reporting, collation, and analysis of critical incidents. To inform a provincial working group's recommendations for an Ontario Patient Safety Event Learning System, a systematic review was undertaken to determine design features that would optimize its adoption into the health care system and would inform implementation strategies. METHODS: The objective of this review was to address two research questions: (a) what are the barriers to and facilitators of successful adoption of a patient safety learning system reported by health professionals and (b) what design components maximize successful adoption and implementation? To answer the first question, we used a published systematic review...
2017: Ontario Health Technology Assessment Series
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