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https://www.readbyqxmd.com/read/28340354/mechanism-of-substrate-translocation-in-an-alternating-access-transporter
#1
Naomi R Latorraca, Nathan M Fastman, A J Venkatakrishnan, Wolf B Frommer, Ron O Dror, Liang Feng
Transporters shuttle molecules across cell membranes by alternating among distinct conformational states. Fundamental questions remain about how transporters transition between states and how such structural rearrangements regulate substrate translocation. Here, we capture the translocation process by crystallography and unguided molecular dynamics simulations, providing an atomic-level description of alternating access transport. Simulations of a SWEET-family transporter initiated from an outward-open, glucose-bound structure reported here spontaneously adopt occluded and inward-open conformations...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28326148/patient-safety-learning-systems-a-systematic-review-and-qualitative-synthesis
#2
(no author information available yet)
BACKGROUND: A patient safety learning system (sometimes called a critical incident reporting system) refers to structured reporting, collation, and analysis of critical incidents. To inform a provincial working group's recommendations for an Ontario Patient Safety Event Learning System, a systematic review was undertaken to determine design features that would optimize its adoption into the health care system and would inform implementation strategies. METHODS: The objective of this review was to address two research questions: (a) what are the barriers to and facilitators of successful adoption of a patient safety learning system reported by health professionals and (b) what design components maximize successful adoption and implementation? To answer the first question, we used a published systematic review...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28323635/magnetic-states-of-mnp-muon-spin-rotation-studies
#3
R Khasanov, A Amato, P Bonfà, Z Guguchia, H Luetkens, E Morenzoni, R De Renzi, N D Zhigadlo
Muon-spin rotation data collected at ambient pressure (p) and at p  =  2.42 GPa in MnP were analyzed to check their consistency with various low- and high-pressure magnetic structures reported in the literature. Our analysis confirms that in MnP the low-temperature and low-pressure helimagnetic phase is characterised by an increased value of the average magnetic moment compared to the high-temperature ferromagnetic phase. An elliptical double-helical structure with a propagation vector [Formula: see text], an a-axis moment elongated by approximately 18% and an additional tilt of the rotation plane towards c-direction by [Formula: see text]-8° leads to a good agreement between the theory and the experiment...
April 26, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28322271/mechanistic-and-structural-basis-of-bioengineered-bovine-cathelicidin-5-with-optimized-therapeutic-activity
#4
Bikash R Sahoo, Kenta Maruyama, Jyotheeswara R Edula, Takahiro Tougan, Yuxi Lin, Young-Ho Lee, Toshihiro Horii, Toshimichi Fujiwara
Peptide-drug discovery using host-defense peptides becomes promising against antibiotic-resistant pathogens and cancer cells. Here, we customized the therapeutic activity of bovine cathelicidin-5 targeting to bacteria, protozoa, and tumor cells. The membrane dependent conformational adaptability and plasticity of cathelicidin-5 is revealed by biophysical analysis and atomistic simulations over 200 μs in thymocytes, leukemia, and E. coli cell-membranes. Our understanding of energy-dependent cathelicidin-5 intrusion in heterogeneous membranes aided in designing novel loss/gain-of-function analogues...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295332/crystalline-phases-found-in-rapidly-quenched-ni-nb-zr-alloys
#5
L P Deo, M J Kaufman, B Wang, S Nikodemski, M F DE Oliveira
The properties of metallic alloys can be significantly improved by developing non-equilibrium phases in the microstructures through rapid solidification techniques, thus the characterisation of these unusual structures is extremely important. In this research, the microstructures of three rapidly quenched alloys, namely Ni65.2 Nb33.8 Zr1.0 , Ni54.8 Nb31.1 Zr14.1 and Ni54.8 Nb21.6 Zr23.6 (at. %) were investigated in greater detail in order to determine the structures and compositions of their crystalline phases...
March 15, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28289942/structured-reporting-of-mri-of-the-shoulder-improvement-of-report-quality
#6
Sebastian Gassenmaier, Marco Armbruster, Florian Haasters, Tobias Helfen, Thomas Henzler, Sedat Alibek, Dominik Pförringer, Wieland H Sommer, Nora N Sommer
OBJECTIVES: To evaluate the effect of structured reports (SRs) in comparison to non-structured narrative free text (NRs) shoulder MRI reports and potential effects of both types of reporting on completeness, readability, linguistic quality and referring surgeons' satisfaction. METHODS: Thirty patients after trauma or with suspected degenerative changes of the shoulder were included in this study (2012-2015). All patients underwent shoulder MRI for further assessment and possible surgical planning...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28259629/structured-reporting-of-ct-examinations-in-acute-pulmonary-embolism
#7
Bastian O Sabel, Jessica L Plum, Nikolaus Kneidinger, Gabriela Leuschner, Leandra Koletzko, Bijan Raziorrouh, Regina Schinner, Wolfgang G Kunz, Franziska Schoeppe, Kolja M Thierfelder, Wieland H Sommer, Felix G Meinel
OBJECTIVES: To evaluate the effect of structured reporting of CT pulmonary angiography (CTPA) studies on the content, clarity and clinical usefulness of radiology reports in acute pulmonary embolism (PE). METHODS: Conventional and structured reports were generated for 41 patients with a CTPA positive for acute PE. Conventional reports were dictated in a free-text form using speech recognition; structured reports contained a consistent ordering of observations with standardized subheadings...
February 22, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28220929/increasing-the-efficiency-on-producing-radiology-reports-for-breast-cancer-diagnosis-by-means-of-structured-reports-a-comparative-study
#8
J Damian Segrelles, Rosana Medina, Ignacio Blanquer, Luis Martí-Bonmatí
BACKGROUND: Radiology reports are commonly written on free-text using voice recognition devices. Structured reports (SR) have a high potential but they are usually considered more difficult to fill-in so their adoption in clinical practice leads to a lower efficiency. However, some studies have demonstrated that in some cases, producing SRs may require shorter time than plain-text ones. This work focuses on the definition and demonstration of a methodology to evaluate the productivity of software tools for producing radiology reports...
February 21, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28190870/the-complexity-of-glycoprotein-derived-glycans
#9
REVIEW
Johannes F G Vliegenthart
A brief review is presented of our studies on the structure of glycoprotein-derived glycans. The emphasis is on the introduction of high-resolution (1)H-NMR spectroscopy for the unambiguous determination of primary structures. For this purpose, we developed the structural reporter group concept. Structural reporters are defined as unique markers of structural elements in the NMR spectra. Application of this concept led to the discovery of numerous new structures. Furthermore, a number of structures presented in the literature could be corrected...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/28188295/myroilysin-is-a-new-bacterial-member-of-the-m12a-family-of-metzincin-metallopeptidases-and-activated-by-a-cysteine-switch-mechanism
#10
Dongqing Xu, Jiale Zhou, Xiangdi Lou, Jianhua He, Tingting Ran, Weiwu Wang
Proteases play important roles in all living organisms and also have important industrial applications. Family M12A metalloproteases, mainly found throughout the animal kingdom, belong to the metzincin protease family and are synthesized as inactive precursors. So far, only flavastacin and myroilysin, isolated from bacteria, were reported to be M12A proteases, whilst the classification of myroilysin is still conflicting due to the lack of structural information. Here, we report the crystal structures of pro-myroilysin from bacterium Myroides sp...
February 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28166486/drinking-motives-of-adult-patients-seeking-treatment-for-problematic-alcohol-use
#11
Anders Hammarberg, Caisa Öster, Christina Nehlin
INTRODUCTION: The Drinking Motives Questionnaire (DMQ) measures motives for alcohol consumption on four subscales. Coping with negative affect and enhancement of positive affect have been shown to be associated with high levels of alcohol consumption and alcohol-related problems. Few studies exist concerning drinking motives among treatment-seeking patients. The aims of the study were to investigate the factor structure of the shortened form of the revised DMQ (DMQ-R SF), map main drinking, explore group differences in motives due to sex, age, level of drinking problems and symptoms of depression/anxiety and to investigate whether different drinking motives predict alcohol-related problems in this group...
February 6, 2017: Journal of Addictive Diseases
https://www.readbyqxmd.com/read/28139419/prostate-mri-for-brachytherapists-diagnosis-imaging-pitfalls-and-post-therapy-assessment
#12
REVIEW
A M Venkatesan, R J Stafford, C Duran, P D Soni, A Berlin, P W McLaughlin
Optimal integration of multiparametric MRI (mp MRI) into prostate brachytherapy practice necessitates an understanding of imaging findings pertinent to prostate cancer detection and staging. This review will summarize prostate cancer imaging findings and tumor staging on mp MRI, including an overview of the Prostate Imaging Reporting and Data System (PIRADS)-structured reporting schema, mp MRI findings observed in the post-therapy setting including cases of post-treatment recurrence, and MRI concepts integral to successful salvage brachytherapy...
January 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28117250/autopopulation-of-intravenous-contrast-type-and-dose-in-structured-report-templates-decreases-report-addenda
#13
Shlomit Goldberg-Stein, David Gutman, Oleg Kaplun, Dan Wang, Abdissa Negassa, Meir H Scheinfeld
No abstract text is available yet for this article.
January 20, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28110570/-computer-tomography-examination-of-the-coronary-system-national-plaque-registry-and-database-hungary
#14
Zsolt Bagyura, Márton Kolossváry, Béla Merkely, Pál Maurovich-Horvat
INTRODUCTION AND AIM: Coronary computer tomography angiography is a unique non-invasive imaging technique with the capability to provide information regarding plaque quantity, burden and structure. A reliable registry is required to use the data of these examinations in research projects. The difficulty is that registries need double data entry simultaneously to the hospital information system. METHOD: Our registry solves this problem through a structured reporting tool, which generates clinical report and stores all data simultaneously...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28104315/implementing-a-structured-reporting-initiative-using-a-collaborative-multistep-approach
#15
Shlomit Goldberg-Stein, William R Walter, E Stephen Amis, Meir H Scheinfeld
PURPOSE: To describe the successful implementation of a structured reporting initiative in a large urban academic radiology department. METHODS: We describe our process, compromises, and top 10 lessons learned in overhauling traditional reporting practices and comprehensively implementing structured reporting at our institution. To achieve our goals, we took deliberate steps toward consensus building, undertook multistep template refinement, and achieved close collaboration with the technical staff, department coders, and hospital information technologists...
December 15, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28096724/essential-items-for-structured-reporting-of-rectal-cancer-mri-2016-consensus-recommendation-from-the-korean-society-of-abdominal-radiology
#16
REVIEW
(no author information available yet)
High-resolution rectal MRI plays a crucial role in evaluating rectal cancer by providing multiple prognostic findings and imaging features that guide proper patient management. Quality reporting is critical for accurate effective communication of the information among multiple disciplines, for which a systematic structured approach is beneficial. Existing guides on reporting of rectal MRI are divergent on some issues, largely reflecting the differences in overall management of rectal cancer patients between the United States and Europe...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28091605/cubosomes-from-hierarchical-self-assembly-of-poly-ionic-liquid-block-copolymers
#17
Hongkun He, Khosrow Rahimi, Mingjiang Zhong, Ahmed Mourran, David R Luebke, Hunaid B Nulwala, Martin Möller, Krzysztof Matyjaszewski
Cubosomes are micro- and nanoparticles with a bicontinuous cubic two-phase structure, reported for the self-assembly of low molecular weight surfactants, for example, lipids, but rarely formed by polymers. These objects are characterized by a maximum continuous interface and high interface to volume ratio, which makes them promising candidates for efficient adsorbents and host-guest applications. Here we demonstrate self-assembly to nanoscale cuboidal particles with a bicontinuous cubic structure by amphiphilic poly(ionic liquid) diblock copolymers, poly(acrylic acid)-block-poly(4-vinylbenzyl)-3-butyl imidazolium bis(trifluoromethylsulfonyl)imide, in a mixture of tetrahydrofuran and water under optimized conditions...
January 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28069356/radiology-reports-what-you-think-you-re-saying-and-what-they-think-you-re-saying
#18
Bonmyong Lee, Matthew T Whitehead
BACKGROUND: Image interpretation and translation into written language is an imperfect process. Yet, the radiology report represents the link between radiologist's opinion and patient's images. Increased access to images through remote viewing stations has made direct communication between radiologists and clinicians less commonplace. We are interested in how accurately the descriptive contents within radiology reports convey the feelings of the radiologist to the referring clinician...
November 16, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28062089/structured-reporting-of-magnetic-resonance-enterography-for-pediatric-crohn-s-disease-effect-on-key-feature-reporting-and-subjective-assessment-of-disease-by-referring-physicians
#19
Benjamin Wildman-Tobriner, Brian C Allen, Joseph T Davis, Chad M Miller, Gary R Schooler, Nancy M McGreal, Reinaldo Quevedo, Julie K Thacker, Tracy A Jaffe
PURPOSE: To objectively compare the content of structured reports (SR) vs nonstructured reports (NSR) for magnetic resonance enterography (MRE) of pediatric patients with Crohn's disease, and to evaluate referring clinicians' subjective assessment of reports. METHODS: This institutional review board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study included 25 pediatric subjects (15 male, 10 female; mean age = 14 years [range: 9-18 years]) with Crohn's disease imaged with MRE...
March 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28048685/tu-d-201-08-experience-complying-with-the-joint-commission-element-of-performance-on-radiation-dose-index-monitoring
#20
M P Supanich
PURPOSE: A new Joint Commission element of performance effective July 2015 requires incidents where the radiation dose index exceeds a defined level be reviewed, analyzed and compared to external benchmarks. This work offers a comprehensive review of the CT exams in which the notification level was exceeded and the reason at one academic medical center. This review may help other institutions set reference levels at clinically relevant values. METHODS: Radiation Dose Structured Reports from each of the 5 diagnostic CT scanners at our institution are automatically sent to our radiation dose index monitoring software platform, Radimetrics from Bayer Healthcare...
June 2016: Medical Physics
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