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https://www.readbyqxmd.com/read/28634390/increased-glutamate-in-somatosensory-cortex-in-functional-dyspepsia
#1
Arthur D P Mak, Georg Northoff, David K W Yeung, Winnie C W Chu, Steve C N Hui, Cynthia Cheung, Jessica Ching, Linda Lam, Sing Lee, Justin Wu
Functional Dyspepsia-Post-prandial Distress Syndrome (FD-PDS) was associated with mood-related increases in resting activity and lowered activation threshold in the somatosensory cortex (SSC), insula and perigenual anterior cingulate cortex(pgACC) in functional imaging studies. The underlying cortical neurochemical changes are unknown. We performed proton Magnetic Resonance Spectroscopy (1H-MRS) on 17 consecutive tertiary clinic-recruited psychotropic-naïve Rome III FD-PDS female and 17 age-sex matched healthy controls...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633971/manganese-enhanced-magnetic-resonance-imaging-depicts-brain-activity-in-models-of-acute-and-chronic-pain-a-new-window-to-study-experimental-spontaneous-pain
#2
I M Devonshire, J J Burston, L Xu, A Lillywhite, M J Prior, D J G Watson, C M Greenspon, S J Iwabuchi, D P Auer, V Chapman
Application of functional imaging techniques to animal models is vital to understand pain mechanisms, but is often confounded by the need to limit movement artefacts with anaesthesia, and a focus on evoked responses rather than clinically relevant spontaneous pain and related hyperalgesia. The aim of the present study was to investigate the potential of manganese-enhanced magnetic resonance imaging (MEMRI) to measure neural responses during on-going pain that underpins hyperalgesia in pre-clinical models of nociception...
June 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28628556/real-time-imaging-of-epileptic-seizures-in-rats-using-electrical-impedance-tomography
#3
Lei Wang, Yang Sun, Xinmin Xu, Xiuzhen Dong, Feng Gao
The presence of multiple or diffuse lesions on imaging is a contraindication to surgery for patients with intractable epilepsy. Theoretically, as a functional imaging technique, electrical impedance tomography (EIT) can accurately image epileptic foci. However, most current studies are limited to examining epileptic spikes and few studies use EIT for real-time imaging of seizure activity. Moreover, little is known about changes in electrical impedance during seizures. In this study, we used EIT to monitor seizure progression in real time and analyzed changes in electrical impedance during seizures...
June 16, 2017: Neuroreport
https://www.readbyqxmd.com/read/28624007/cardiac-mri-left-ventricular-global-function-index-and-quantitative-late-gadolinium-enhancement-in-unrecognized-myocardial-infarction
#4
Patrick Krumm, Tanja Zitzelsberger, Melanie Weinmann, Stefanie Mangold, Dominik Rath, Konstantin Nikolaou, Meinrad Gawaz, Ulrich Kramer, Bernhard Daniel Klumpp
PURPOSE: To compare left ventricular global function index (LVGFI) and quantitative late gadolinium enhancement (LGE) in patients with unrecognized myocardial infarction (UMI), recognized myocardial infarction (RMI) and without myocardial infarction (MI). MATERIAL AND METHODS: Under waiver of the Institutional Review Board 235 patients (age 63.5±10.5years, 57 female) were retrospectively evaluated. All patients had undergone cardiac MRI at 1.5T for symptoms of CAD...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28621768/imaging-and-fluid-biomarkers-in-frontotemporal-dementia
#5
REVIEW
Lieke H Meeter, Laura Donker Kaat, Jonathan D Rohrer, John C van Swieten
Frontotemporal dementia (FTD), the second most common type of presenile dementia, is a heterogeneous neurodegenerative disease characterized by progressive behavioural and/or language problems, and includes a range of clinical, genetic and pathological subtypes. The diagnostic process is hampered by this heterogeneity, and correct diagnosis is becoming increasingly important to enable future clinical trials of disease-modifying treatments. Reliable biomarkers will enable us to better discriminate between FTD and other forms of dementia and to predict disease progression in the clinical setting...
June 16, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28620348/the-utility-of-fdg-pet-ct-in-clinically-suspected-paraneoplastic-neurological-syndrome-a-literature-review-and-retrospective-case-series
#6
Mark P Maskery, Jonathan Hill, John R Cain, Hedley C A Emsley
Paraneoplastic neurological syndrome (PNS) describes a spectrum of rare, heterogeneous neurological conditions associated with an underlying malignancy. Diagnosis of PNS is inherently difficult, with frequent misdiagnosis and delay. The literature suggests an underlying immune-mediated pathophysiology, and patients are usually tested for the presence of onconeural antibodies. With direct tumor therapy being the most effective method of stabilizing patients, there is a strong emphasis on detecting underlying tumors...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28620320/abnormal-haemodynamic-flow-patterns-in-bicuspid-pulmonary-valve-disease
#7
Malenka M Bissell, Margaret Loudon, Stefan Neubauer, Saul G Myerson
Abnormal flow patterns in the aortas of those with bicuspid aortic valves (BAVs) are increasingly recognized as important in the pathogenesis of aortic dilatation but pulmonary flow patterns in bicuspid pulmonary valves have not been studied. Bicuspid pulmonary valve disease is rare and a small numbers of case reports describe concomitant pulmonary artery dilation similar to the dilation of the ascending aorta, which is often seen in BAVs disease. We examined three cases of bicuspid pulmonary valve disease, 10 healthy volunteers and 10 patients with BAV disease but a tricuspid pulmonary valve...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28609290/functional-imaging-of-brown-adipose-tissue-in-human
#8
REVIEW
Hamza El Hadi, Roberto Vettor, Marco Rossato
Obesity has become a major public health challenge and an increasing trend is seen in its prevalence worldwide. It is a complex disorder involving an excessive amount of body fat as a result of an energy imbalance leading to caloric overload. Since the discovery of functional brown adipose tissue (BAT) in adult humans, with energy dissipating properties, this thermogenic tissue has thus emerged as an attractive therapeutic target to combat obesity and related cardiometabolic disorders. The advancements in imaging modalities to evaluate organ-specific metabolism in humans is substantially contributing to understand the physiological role of BAT...
June 13, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28607514/evolution-of-lymphoma-staging-and-response-evaluation-current-limitations-and-future-directions
#9
REVIEW
Joel Cunningham, Sunil Iyengar, Bhupinder Sharma
The accurate detection and precise assessment of therapeutic responses is critical to the optimal management of patients with lymphoma. Over the past 50 years, dramatic advances in technology have established imaging as the cornerstone of disease evaluation. However, the appropriate application of current techniques requires acknowledgement of their strengths and weaknesses, and appreciation of the full diversity of lymphoid neoplasms. The role of anatomical and functional imaging in detection, treatment escalation/de-escalation and prognostication of patients with lymphoma can be misinterpreted...
June 13, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28605991/-i-in-vivo-i-assessment-of-engineered-skin-cell-delivery-with-multimodal-optical-microscopy
#10
Andrew J Bower, Ziad Mahmassani, Youbo Zhao, Eric J Chaney, Marina Marjanovic, Min Kyung Lee, Benedikt Graf, Michael De Lisio, Hyun Joon Kong, Marni D Boppart, Stephen A Boppart
The healing process is often significantly impaired under conditions of chronic or large area wounds, which are often treated clinically using autologous split-thickness skin grafts. However, in many cases, harvesting of donor tissue presents a serious problem such as in the case of very large area burns. In response to this, engineered biomaterials have emerged that attempt to mimic the natural skin environment or deliver a suitable therapy to assist in the healing process. In this study, a custom-built multimodal optical microscope capable of noninvasive structural and functional imaging is used to investigate both the engineered tissue microenvironment and the <i>in vivo</i> wound healing process...
June 12, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28600674/-value-of-cardiac-ct-in-the-diagnostic-work-up-of-coronary-artery-disease-update-2017
#11
M Meyer, T Henzler
The quantification of coronary calcifications using noncontrast-enhanced computed tomography (CT) as well as coronary CT angiography (cCTA) have rapidly evolved in the recent years. Nowadays, both techniques are increasingly clinically accepted regarding risk stratification and accurate exclusion of significant coronary artery disease (CAD). The higher acceptance of cCTA is mainly based on the higher robustness, lower radiation exposure through continuous technical innovations as well as by the growing scientific evidence...
June 9, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28596724/recent-advances-in-translational-magnetic-resonance-imaging-in-animal-models-of-stress-and-depression
#12
REVIEW
Allison L McIntosh, Shane Gormley, Leonardo Tozzi, Thomas Frodl, Andrew Harkin
Magnetic resonance imaging (MRI) is a valuable translational tool that can be used to investigate alterations in brain structure and function in both patients and animal models of disease. Regional changes in brain structure, functional connectivity, and metabolite concentrations have been reported in depressed patients, giving insight into the networks and brain regions involved, however preclinical models are less well characterized. The development of more effective treatments depends upon animal models that best translate to the human condition and animal models may be exploited to assess the molecular and cellular alterations that accompany neuroimaging changes...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28586147/epileptic-networks-in-action-synchrony-between-distant-hemodynamic-responses
#13
Hui Ming Khoo, Nicolás von Ellenrieder, Natalja Zazubovits, François Dubeau, Jean Gotman
OBJECTIVE: Structural and functional imaging studies in focal epilepsy often reveal distributed regions of abnormality. These are interpreted as representing the existence of epileptic networks but the presence of actual neuronal interactions between these regions has not been demonstrated. We sought to determine if the distributed hemodynamic responses often seen in fMRI studies of scalp interictal epileptic discharges (IEDs) actually correspond to synchronized neuronal activities when examining the intracerebral EEG (iEEG) at distant nodes of the network...
June 6, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28584311/takotsubo-cardiomyopathy-in-the-case-of-72-year-old-teacher-after-work-related-psychological-stress-evolution-of-left-ventricular-longitudinal-strain-delayed-but-complete-recovery-in-automated-function-imaging-afi
#14
Karina Wierzbowska-Drabik, Andrzej Marcinkiewicz, Piotr Hamala, Ewa Trzos, Piotr Lipiec, Małgorzata Kurpesa, Radosław Kręcki, Michał Plewka, Jarosław D Kasprzak
Takotsubo cardiomyopathy (TC) is related to a transient systolic dysfunction of left ventricle (LV), accompanied by clinical and electrocardiographic symptoms of myocardial ischemia in the absence of hemodynamically significant coronary artery disease. Takotsubo cardiomyopathy is usually provoked by a psychologically or/and physically stressful event which may be related to occupational activities. Although visually assessed evolution of LV function is well documented, the data concerning strain changes is sparse and various patterns of deformation abnormalities are suggested...
March 23, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28582917/potential-for-false-positive-results-from-multi-voxel-pattern-analysis-on-functional-imaging-data
#15
Zuo Zhang, Youhao Jiang, Yaoru Sun, Hong Zhang
BACKGROUND: Multi-voxel pattern analysis (MVPA) provides a powerful tool to investigate neural mechanisms for various cognitive processes under functional brain imaging. However, the high sensitivity of the MVPA method could bring about false positive results, which has been overlooked by previous research. OBJECTIVE: We investigated the potential for obtaining false positives from the MVPA method. METHODS: We conducted MVPA on a public functional MRI dataset on the neural encoding of various object categories...
May 26, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28579965/neural-correlates-of-psychotherapeutic-treatment-of-post-traumatic-stress-disorder-a-systematic-literature-review
#16
Kathrin Malejko, Birgit Abler, Paul L Plener, Joana Straub
OBJECTIVES: Post-traumatic stress disorder (PTSD) is a common psychiatric disease with changes in neural circuitries. Neurobiological models conceptualize the symptoms of PTSD as correlates of a dysfunctional stress reaction to traumatic events. Functional imaging studies showed an increased amygdala and a decreased prefrontal cortex response in PTSD patients. As psychotherapeutic approaches represent the gold standard for PTSD treatment, it is important to examine its underlying neurobiological correlates...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28570322/autoimmune-neurology-of-the-central-nervous-system
#17
W Oliver Tobin, Sean J Pittock
PURPOSE OF REVIEW: This article reviews the rapidly evolving spectrum of autoimmune neurologic disorders with a focus on those that involve the central nervous system, providing an understanding of how to approach the diagnostic workup of patients presenting with central nervous system symptoms or signs that could be immune mediated, either paraneoplastic or idiopathic, to guide therapeutic decision making. RECENT FINDINGS: The past decade has seen a dramatic increase in the discovery of novel neural antibodies and their targets...
June 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28560766/systolic-longitudinal-strain-correlates-with-visual-assessment-of-regional-left-ventricular-function-during-dobutamine-stress-echocardiography-and-discriminates-the-segments-with-induced-contractility-impairment
#18
Karina Wierzbowska-Drabik, Dawid Miśkowiec, Jarosław D Kasprzak
BACKGROUND: The relationship between visual and strain assessment of left ventricular (LV) function during dobutamine stress echocardiography (DSE) remains poorly investigated. We assessed systolic longitudinal strain (SLS) and strain rate (SLSR) in segments visually graded as normokinetic, hypokinetic, or akinetic at baseline (0) and peak stage (1) of DSE and compared deformation changes between segments with and without induced contractility worsening. METHODS: From 250 patients examined by DSE, 238 patients with diagnostic test were included, mean age of 62±9 years (105 females)...
May 30, 2017: Echocardiography
https://www.readbyqxmd.com/read/28560261/brain-structure-function-and-neurochemistry-in-schizophrenia-and-bipolar-disorder-a-systematic-review-of-the-magnetic-resonance-neuroimaging-literature
#19
Badari Birur, Nina Vanessa Kraguljac, Richard C Shelton, Adrienne Carol Lahti
Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia praecox and manic depression, the separation between primary psychotic disorders and primary affective disorders has been much debated. We conducted a systematic review of case-control studies contrasting magnetic resonance imaging studies in schizophrenia and bipolar disorder. A literature search in PubMed of studies published between January 2005 and December 2016 was conducted, and 50 structural, 29 functional, 7 magnetic resonance spectroscopy, and 8 combined imaging and genetic studies were deemed eligible for systematic review...
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28559945/sensitive-detection-of-a-small-parathyroid-adenoma-using-fluorocholine-pet-ct-a-case-report
#20
Thanseer N T K Padinhare-Keloth, Sanjay K Bhadada, Ashwani Sood, Rajender Kumar, Arunanshu Behera, Bishan D Radotra, Bhagwant R Mittal
Primary hyperparathyroidism is caused by parathyroid adenoma in the majority of cases and diagnosis is usually made biochemically. Pre-surgical localization of parathyroid adenoma is essential to limit the extent of surgery and avoid missing them at ectopic sites. Anatomical and functional imaging are used for the localization, but may fail to identify the small and ectopic parathyroid adenoma. We present a case of small sized ectopic parathyroid adenoma at unusual location detected by F-18 fluorocholine (FCH) PET/CT, where other imaging modalities failed...
June 2017: Nuclear Medicine and Molecular Imaging
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