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https://www.readbyqxmd.com/read/28163603/rem-sleep-behavior-disorder-rbd-update-on-diagnosis-and-treatment
#1
Birgit Högl, Ambra Stefani
BACKGROUND: REM sleep behavior disorder (RBD) is parasomnia characterized by dream enactment and enabled by disruption of physiological muscle atonia during REM sleep. Over the past few years, diagnostic criteria and the methods used to confirm diagnosis have been updated. OBJECTIVE: In this review article, the current knowledge regarding RBD diagnosis and treatment is presented. METHODS: A selective literature search was carried out. RESULTS AND DISCUSSION: Although several RBD screening questionnaires have been developed, diagnosis can only be definitely confirmed on the basis of polysomnography...
2017: Somnologie: Schlafforschung und Schlafmedizin, Somnology: Sleep Research and Sleep Medicine
https://www.readbyqxmd.com/read/28096570/tourniquet-application-during-anesthesia-what-we-need-to-know
#2
REVIEW
Kamal Kumar, Craig Railton, Qutaiba Tawfic
Tourniquets are routinely and safely used in limb surgeries throughout the world. Tourniquet application alters normal physiology. Healthy patients tolerate these physiological changes well, but the physiological changes may not be well-tolerated by patients with poor cardiac function. This review discusses the physiological changes associated with tourniquet use, safe practice and provides the latest updates regarding tourniquet use. A systematic literature search of PubMed, MEDLINE, ScienceDirect, and Google Scholar was done...
October 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28088881/an-industry-update-the-latest-developments-in-therapeutic-delivery
#3
Iain Simpson
This Industry Update covers the period from 1 October through to 31 October 2016, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw several news items covering drug-delivery devices, including a new sensor to monitor and support the use of inhalers; launch in the UK of a new autoinjector for Cimzia(®), UCB's rheumatoid arthritis drug; and approval of Roche's Lucentis(®) in a prefilled syringe. Research was also published to show the value of continuous blood pressure monitoring in dementia management...
February 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28087505/2016-update-of-the-asas-eular-management-recommendations-for-axial-spondyloarthritis
#4
Désirée van der Heijde, Sofia Ramiro, Robert Landewé, Xenofon Baraliakos, Filip Van den Bosch, Alexandre Sepriano, Andrea Regel, Adrian Ciurea, Hanne Dagfinrud, Maxime Dougados, Floris van Gaalen, Pál Géher, Irene van der Horst-Bruinsma, Robert D Inman, Merryn Jongkees, Uta Kiltz, Tore K Kvien, Pedro M Machado, Helena Marzo-Ortega, Anna Molto, Victoria Navarro-Compàn, Salih Ozgocmen, Fernando M Pimentel-Santos, John Reveille, Martin Rudwaleit, Jochen Sieper, Percival Sampaio-Barros, Dieter Wiek, Jürgen Braun
To update and integrate the recommendations for ankylosing spondylitis and the recommendations for the use of tumour necrosis factor inhibitors (TNFi) in axial spondyloarthritis (axSpA) into one set applicable to the full spectrum of patients with axSpA. Following the latest version of the European League Against Rheumatism (EULAR) Standardised Operating Procedures, two systematic literature reviews first collected the evidence regarding all treatment options (pharmacological and non-pharmacological) that were published since 2009...
January 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28077318/alcohol-microbiome-life-style-influence-alcohol-and-non-alcoholic-organ-damage
#5
REVIEW
Manuela G Neuman, Samuel W French, Samir Zakhari, Stephen Malnick, Helmut K Seitz, Lawrence B Cohen, Mikko Salaspuro, Andreea Voinea-Griffin, Andrei Barasch, Irina A Kirpich, Paul G Thomes, Laura W Schrum, Terrence M Donohue, Kusum K Kharbanda, Marcus Cruz, Mihai Opris
This paper is based upon the "8th Charles Lieber's Satellite Symposium" organized by Manuela G. Neuman at the Research Society on Alcoholism Annual Meeting, on June 25, 2016 at New Orleans, Louisiana, USA. The integrative symposium investigated different aspects of alcohol-induced liver disease (ALD) as well as non-alcohol-induced liver disease (NAFLD) and possible repair. We revealed the basic aspects of alcohol metabolism that may be responsible for the development of liver disease as well as the factors that determine the amount, frequency and which type of alcohol misuse leads to liver and gastrointestinal diseases...
January 7, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28017154/advances-in-micelle-based-drug-delivery-cross-linked-systems
#6
İsmail Alper İşoğlu, Yıldız Özsoy, Sevil Dinçer İşoğlu
There are several barriers that drug molecules encounter in body beginning from kidney filtration and reticulo-endothelial system (RES) clearance to cellular trafficking. Multifunctional nanocarriers have a great potential for the delivery of drugs by enhancing therapeutic activity of existing methodologies. A variety of nanocarriers are constructed by different material types, which have unique physicochemical properties for drug delivery applications. Micelles formed by amphiphilic polymers are one of the most important drug/nanocarrier formulation products, in which the core part is suitable for encapsulation of hydrophobic agent whereas the outer shell can be utilized for targeting the drug to the disease area...
December 22, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28013373/an-update-on-idiopathic-intracranial-hypertension
#7
Mark Portelli, Panagiotis N Papageorgiou
BACKGROUND: Idiopathic intracranial hypertension (IIH) is still a grey area in the knowledge of the aetiology, diagnosis and management of neurosurgical diseases. The definition of IIH has been reviewed over time and many hypotheses have been expressed as cause of the disease. The literature supplies very little evidence-based information to guide our decision-making process when it comes to treat the disease. In this review we sum up the latest information regarding the aetiology and therapy of IIH...
March 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27857513/difficulties-in-the-diagnosis-and-management-of-hyponatremia
#8
REVIEW
Mihaela Mocan, Lia Manuela Terheş, Sorin Nicu Blaga
Hyponatremia is the most common electrolyte imbalance encountered in clinical practice. Beside the difficulty of the etiological diagnosis, the general lack of awareness regarding the negative impact of hyponatremia on the quality of life and the lack of targeted treatments until recent years may be responsible for the poor management of the disorder. Therefore we consider of utmost importance to improve the knowledge regarding the diagnosis and management of hyponatremia, by underlining the difficulties of the etiological diagnosis and its management...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27572514/clinical-update-on-dengue-chikungunya-and-zika-what-we-know-at-the-time-of-article-submission
#9
Liang E Liu, Meaghan Dehning, Ashley Phipps, Ray E Swienton, Curtis A Harris, Kelly R Klein
OBJECTIVE: Mosquito-borne diseases pose a threat to individual health and population health on both a local and a global level. The threat is even more exaggerated during disasters, whether manmade or environmental. With the recent Zika virus outbreak, it is important to highlight other infections that can mimic the Zika virus and to better understand what can be done as public health officials and health care providers. METHODS: This article reviews the recent literature on the Zika virus as well as chikungunya virus and dengue virus...
August 30, 2016: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/27552521/kangaroo-mother-care-to-reduce-morbidity-and-mortality-in-low-birthweight-infants
#10
REVIEW
Agustin Conde-Agudelo, José L Díaz-Rossello
BACKGROUND: Kangaroo mother care (KMC), originally defined as skin-to-skin contact between a mother and her newborn, frequent and exclusive or nearly exclusive breastfeeding, and early discharge from hospital, has been proposed as an alternative to conventional neonatal care for low birthweight (LBW) infants. OBJECTIVES: To determine whether evidence is available to support the use of KMC in LBW infants as an alternative to conventional neonatal care before or after the initial period of stabilization with conventional care, and to assess beneficial and adverse effects...
August 23, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27527379/complex-coronoid-and-proximal-ulna-fractures-are-we-getting-better-at-fixing-these
#11
REVIEW
Richard S Yoon, Vineet Tyagi, Matthew B Cantlon, Aldo M Riesgo, Frank A Liporace
Technological advances and improved understanding of functional anatomy about the elbow have lead an evolution regarding operative reconstruction of complex proximal ulnar and coronoid fractures. When treating these complex and challenging fractures, goals of anatomic articular restoration along with balanced soft tissue stability can lead to early range of motion and thus, desired functional outcome. The purpose of this review is to outline and provide tips and pearls to achieve desired results, with a comprehensive update on the most recent literature to support the latest fixation methods and techniques...
October 2016: Injury
https://www.readbyqxmd.com/read/27514316/combined-modality-therapy-for-thoracic-and-head-and-neck-cancers-a-review-of-updated-literature-based-on-a-consensus-meeting
#12
REVIEW
Pierfrancesco Franco, Alba Fiorentino, Francesco Dionisi, Michele Fiore, Silvia Chiesa, Stefano Vagge, Francesco Cellini, Luciana Caravatta, Mario Tombolini, Fiorenza De Rose, Icro Meattini, Gianluca Mortellaro, Giuseppina Apicella, Lorenza Marino, Daniela Greto
PURPOSE: Combined modality therapy is a mainstay option for thoracic malignancies and head and neck cancers. The integration of different strategies is based on the multidisciplinary approach of modern clinical oncology. Radiation oncologists have to be educated, trained, and updated to provide state-of-the-art care to cancer patients and thus educational meetings are crucial. METHODS: The Italian Association of Radiation Oncology Young Members Working Group (AIRO Giovani) organized its 8th national meeting, focused on combination therapy in lung, esophageal, and head and neck cancer (with a specific focus on larynx-preservation strategies for larynx/hypopharynx tumors), involving young professionals working in Italy...
October 13, 2016: Tumori
https://www.readbyqxmd.com/read/27491402/egfr-and-eml4-alk-updated-therapies-in-non-small-cell-lung-cancer
#13
Ramon Andrade de Mello, Davi J J Liu, Pedro N Aguiar, Hakaru Tadokoro
BACKGROUND: Non-small cell lung cancer is the leading cancer-related cause of death. OBJECTIVE: We review the latest therapies for NSCLC with EGFR and ELM4-ALK mutations as well as the most relevant studies and promising patents. METHOD: A literature search of PubMed database was carried out to identify recent Clinical Trials using EGFR therapies and novel patents involving diagnosis and therapies on NSCLC. We conducted a search to find new therapy strategies, new biomarkers, and selected five patents we find relevant...
2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27467174/functional-mitral-regurgitation-in-patients-with-heart-failure-and-depressed-ejection-fraction
#14
Aeshita Dwivedi, Alan Vainrib, Muhamed Saric
PURPOSE OF REVIEW: Functional mitral regurgitation (FMR) is a common complication of left ventricular dysfunction. It is now recognized as an important clinical entity and an independent predictor of poor prognosis in cardiomyopathy patients. In this review, we provide a comprehensive summary of the pathophysiology, latest imaging modalities, and diagnostic criteria for FMR. Additionally, we discuss the recent literature on the continuously evolving surgical and percutaneous treatment options...
September 2016: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27457396/-assisted-vaginal-delivery
#15
O Šimetka, I Michalec
UNLABELLED: This article is meant to be a complement to the new statement "Assisted vaginal delivery" of the Section of perinatal and fetomaternal medicine (SPFM) of the Czech Society of Gynecology and Obstetrics ČLS JEP, which is also published in this issue of Czech gynecology. The new statement has been formed as a synthesis of two previous separate statements of the SPFM "Vacuumextraction" and "Forceps delivery" and has also been updated based on new scientific knowledge. This review publication summarizes latest knowledge on vacuumextraction and forceps delivery and adds comments to certain points from the statement...
April 2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27446825/celiac-disease-and-gluten-free-oats-a-canadian-position-based-on-a-literature-review
#16
REVIEW
Sébastien La Vieille, Olga M Pulido, Michael Abbott, Terence B Koerner, Samuel Godefroy
This paper provides an overview of the latest scientific data related to the safety of uncontaminated oats (<20 ppm of gluten) in the diet of individuals with celiac disease (CD). It updates the previous Health Canada position posted on the Health Canada website in 2007 and a related paper published in 2009. It considers a number of recent studies published between January 2008 and January 2015. While recognizing that a few people with celiac disease seem to be clinically intolerant to oats, this review concludes that oats uncontaminated by gluten-containing cereals (wheat, rye, and barley) can be safely ingested by most patients with celiac disease and that there is no conclusive evidence that the consumption of uncontaminated or specially produced oats containing no greater than 20 ppm gluten by patients with celiac disease should be limited to a specific daily amount...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27404790/carbon-nanotubes-application-in-the-extraction-techniques-of-pesticides-a-review
#17
REVIEW
Aleksandra Jakubus, Monika Paszkiewicz, Piotr Stepnowski
Carbon nanotubes (CNTs) are currently one of the most promising groups of materials with some interesting properties, such as lightness, rigidity, high surface area, high mechanical strength in tension, good thermal conductivity or resistance to mechanical damage. These unique properties make CNTs a competitive alternative to conventional sorbents used in analytical chemistry, especially in extraction techniques. The amount of work that discusses the usefulness of CNTs as a sorbent in a variety of extraction techniques has increased significantly in recent years...
January 2, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/27357497/sleep-problems-in-children-with-attention-deficit-hyperactivity-disorder-current-status-of-knowledge-and-appropriate-management
#18
REVIEW
Ming-Horng Tsai, Jen-Fu Hsu, Yu-Shu Huang
Attention deficit hyperactivity disorder (ADHD) affects approximately 5 % of children and adolescents, and sleep problems are common in these patients. There is growing evidence informing the significant importance of sleep problems in youth with ADHD. The sleep problems in children with ADHD include specific sleep disorders and sleep disturbances due to comorbid psychiatric disorders or ADHD medications. The specific sleep disorders of ADHD children include behaviorally based insomnia, sleep-disordered breathing, and restless legs syndrome/periodic limb movement disorder...
August 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27339569/an-evaluation-of-acute-respiratory-infection-surveillance-systems-in-gilgit-baltistan-pakistan
#19
Zakir Hussain, Jameel Ahmed Ansari, Muhammad Salman, Ejaz Ahmed Khan, Jawad Asghar
BACKGROUND: Acute Respiratory Infections (ARIs) are leading cause of death among children and cause 2.1 million deaths worldwide. In Pakistan, around 11.74 million ARIs cases are reported annually. Gilgit Baltistan (G-B) has higher ARIs incidence and mortality among children under 5. Study aims to evaluate the strengths and weaknesses of ARI surveillance systems in GB. METHODOLOGY: Evaluation was conducted during April 2011 using CDC's updated guidelines on evaluating the public health surveillance system, 2001...
June 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27248461/hepatorenal-syndrome-in-cirrhosis-diagnostic-pathophysiological-and-therapeutic-aspects
#20
Troels M Busk, Flemming Bendtsen, Søren Møller
INTRODUCTION: Renal failure is a common and serious complication in cirrhosis and represents a wide spectrum of etiologies. The hepatorenal syndrome (HRS) represents a distinct type of renal failure, only seen in cirrhotic patients with ascites. The diagnostic criteria, knowledge in the pathophysiology of renal failure and HRS, and treatment hereof, have evolved tremendously during the last decades, and it is the aim of this review to summarize these discoveries. AREAS COVERED: The focus will primarily be on treatment and prevention of renal failure and HRS, but areas concerning definition, diagnosis, including biomarkers, and pathophysiology, will also be covered through a comprehensive, critical reading of the latest literature, encompassing the most recent, updated, international guidelines, reviews and high-impact original literature...
June 16, 2016: Expert Review of Gastroenterology & Hepatology
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