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Mihaela Mocan, Lia Manuela Terheş, Sorin Nicu Blaga
Hyponatremia is the most common electrolyte imbalance encountered in clinical practice. Beside the difficulty of the etiological diagnosis, the general lack of awareness regarding the negative impact of hyponatremia on the quality of life and the lack of targeted treatments until recent years may be responsible for the poor management of the disorder. Therefore we consider of utmost importance to improve the knowledge regarding the diagnosis and management of hyponatremia, by underlining the difficulties of the etiological diagnosis and its management...
2016: Clujul Medical (1957)
Liang E Liu, Meaghan Dehning, Ashley Phipps, Ray E Swienton, Curtis A Harris, Kelly R Klein
OBJECTIVE: Mosquito-borne diseases pose a threat to individual health and population health on both a local and a global level. The threat is even more exaggerated during disasters, whether manmade or environmental. With the recent Zika virus outbreak, it is important to highlight other infections that can mimic the Zika virus and to better understand what can be done as public health officials and health care providers. METHODS: This article reviews the recent literature on the Zika virus as well as chikungunya virus and dengue virus...
August 30, 2016: Disaster Medicine and Public Health Preparedness
Agustin Conde-Agudelo, José L Díaz-Rossello
BACKGROUND: Kangaroo mother care (KMC), originally defined as skin-to-skin contact between a mother and her newborn, frequent and exclusive or nearly exclusive breastfeeding, and early discharge from hospital, has been proposed as an alternative to conventional neonatal care for low birthweight (LBW) infants. OBJECTIVES: To determine whether evidence is available to support the use of KMC in LBW infants as an alternative to conventional neonatal care before or after the initial period of stabilization with conventional care, and to assess beneficial and adverse effects...
August 23, 2016: Cochrane Database of Systematic Reviews
Richard S Yoon, Vineet Tyagi, Matthew B Cantlon, Aldo M Riesgo, Frank A Liporace
Technological advances and improved understanding of functional anatomy about the elbow have lead an evolution regarding operative reconstruction of complex proximal ulnar and coronoid fractures. When treating these complex and challenging fractures, goals of anatomic articular restoration along with balanced soft tissue stability can lead to early range of motion and thus, desired functional outcome. The purpose of this review is to outline and provide tips and pearls to achieve desired results, with a comprehensive update on the most recent literature to support the latest fixation methods and techniques...
October 2016: Injury
Pierfrancesco Franco, Alba Fiorentino, Francesco Dionisi, Michele Fiore, Silvia Chiesa, Stefano Vagge, Francesco Cellini, Luciana Caravatta, Mario Tombolini, Fiorenza De Rose, Icro Meattini, Gianluca Mortellaro, Giuseppina Apicella, Lorenza Marino, Daniela Greto
PURPOSE: Combined modality therapy is a mainstay option for thoracic malignancies and head and neck cancers. The integration of different strategies is based on the multidisciplinary approach of modern clinical oncology. Radiation oncologists have to be educated, trained, and updated to provide state-of-the-art care to cancer patients and thus educational meetings are crucial. METHODS: The Italian Association of Radiation Oncology Young Members Working Group (AIRO Giovani) organized its 8th national meeting, focused on combination therapy in lung, esophageal, and head and neck cancer (with a specific focus on larynx-preservation strategies for larynx/hypopharynx tumors), involving young professionals working in Italy...
October 13, 2016: Tumori
Ramon Andrade Bezerra De Mello, Davi Jing Jue Liu, Pedro N Aguiar, Hakaru Tadokoro
: Non-small cell lung cancer is the leading cancer-related cause of death. OBJECTIVE: We review the latest therapies for NSCLC with EGFR and ELM4-ALK mutations as well as the most relevant studies and promising patents. METHOD: A literature search of PubMed database was carried out to identify recent Clinical Trials using EGFR therapies and novel patents involving diagnosis and therapies on NSCLC. We conducted a search to find new therapy strategies, new biomarkers, and selected five patents we find relevant...
August 2, 2016: Recent Patents on Anti-cancer Drug Discovery
Aeshita Dwivedi, Alan Vainrib, Muhamed Saric
PURPOSE OF REVIEW: Functional mitral regurgitation (FMR) is a common complication of left ventricular dysfunction. It is now recognized as an important clinical entity and an independent predictor of poor prognosis in cardiomyopathy patients. In this review, we provide a comprehensive summary of the pathophysiology, latest imaging modalities, and diagnostic criteria for FMR. Additionally, we discuss the recent literature on the continuously evolving surgical and percutaneous treatment options...
September 2016: Current Opinion in Cardiology
O Šimetka, I Michalec
UNLABELLED: This article is meant to be a complement to the new statement "Assisted vaginal delivery" of the Section of perinatal and fetomaternal medicine (SPFM) of the Czech Society of Gynecology and Obstetrics ČLS JEP, which is also published in this issue of Czech gynecology. The new statement has been formed as a synthesis of two previous separate statements of the SPFM "Vacuumextraction" and "Forceps delivery" and has also been updated based on new scientific knowledge. This review publication summarizes latest knowledge on vacuumextraction and forceps delivery and adds comments to certain points from the statement...
April 2016: Ceská Gynekologie
Sébastien La Vieille, Olga M Pulido, Michael Abbott, Terence B Koerner, Samuel Godefroy
This paper provides an overview of the latest scientific data related to the safety of uncontaminated oats (<20 ppm of gluten) in the diet of individuals with celiac disease (CD). It updates the previous Health Canada position posted on the Health Canada website in 2007 and a related paper published in 2009. It considers a number of recent studies published between January 2008 and January 2015. While recognizing that a few people with celiac disease seem to be clinically intolerant to oats, this review concludes that oats uncontaminated by gluten-containing cereals (wheat, rye, and barley) can be safely ingested by most patients with celiac disease and that there is no conclusive evidence that the consumption of uncontaminated or specially produced oats containing no greater than 20 ppm gluten by patients with celiac disease should be limited to a specific daily amount...
2016: Canadian Journal of Gastroenterology & Hepatology
Aleksandra Jakubus, Monika Paszkiewicz, Piotr Stepnowski
Carbon nanotubes are currently one of the most promising groups of materials with an interesting properties such as lightness, rigidity, high surface area, high mechanical strength in tension, good thermal conductivity or resistance to mechanical damage. These unique properties make CNTs a competitive alternative to conventional sorbents used in analytical chemistry, especially in extraction techniques. The amount of work that discusses the usefulness of CNTs as a sorbent in a variety of extraction techniques has increased significantly in recent years...
July 12, 2016: Critical Reviews in Analytical Chemistry
Ming-Horng Tsai, Jen-Fu Hsu, Yu-Shu Huang
Attention deficit hyperactivity disorder (ADHD) affects approximately 5 % of children and adolescents, and sleep problems are common in these patients. There is growing evidence informing the significant importance of sleep problems in youth with ADHD. The sleep problems in children with ADHD include specific sleep disorders and sleep disturbances due to comorbid psychiatric disorders or ADHD medications. The specific sleep disorders of ADHD children include behaviorally based insomnia, sleep-disordered breathing, and restless legs syndrome/periodic limb movement disorder...
August 2016: Current Psychiatry Reports
Zakir Hussain, Jameel Ahmed Ansari, Muhammad Salman, Ejaz Ahmed Khan, Jawad Asghar
BACKGROUND: Acute Respiratory Infections (ARIs) are leading cause of death among children and cause 2.1 million deaths worldwide. In Pakistan, around 11.74 million ARIs cases are reported annually. Gilgit Baltistan (G-B) has higher ARIs incidence and mortality among children under 5. Study aims to evaluate the strengths and weaknesses of ARI surveillance systems in GB. METHODOLOGY: Evaluation was conducted during April 2011 using CDC's updated guidelines on evaluating the public health surveillance system, 2001...
June 2016: JPMA. the Journal of the Pakistan Medical Association
Troels M Busk, Flemming Bendtsen, Søren Møller
INTRODUCTION: Renal failure is a common and serious complication in cirrhosis and represents a wide spectrum of etiologies. The hepatorenal syndrome (HRS) represents a distinct type of renal failure, only seen in cirrhotic patients with ascites. The diagnostic criteria, knowledge in the pathophysiology of renal failure and HRS, and treatment hereof, have evolved tremendously during the last decades, and it is the aim of this review to summarize these discoveries. AREAS COVERED: The focus will primarily be on treatment and prevention of renal failure and HRS, but areas concerning definition, diagnosis, including biomarkers, and pathophysiology, will also be covered through a comprehensive, critical reading of the latest literature, encompassing the most recent, updated, international guidelines, reviews and high-impact original literature...
June 16, 2016: Expert Review of Gastroenterology & Hepatology
Sanjay Pandey, Chaturbhuj Rathore, Benedict D Michael
BACKGROUND: Viral encephalitis is characterised by diverse clinical and epidemiological features. Seizures are an important clinical manifestation and are associated with increased mortality and morbidity. Patients may have seizures during the acute illness or they may develop after recovery. There are no recommendations regarding the use of antiepileptic drugs for the primary or secondary prevention of seizures in patients with viral encephalitis.This is an updated version of the original Cochrane review published in The Cochrane Library 2014, Issue 10...
2016: Cochrane Database of Systematic Reviews
Qinhong Zhang, Jinhuan Yue, Xiangxin Zeng, Zhongren Sun, Brenda Golianu
BACKGROUND: This study aims to investigate the efficacy and safety of acupuncture for patients with chronic neck pain. METHODS: The MEDLINE, EMBASE, CENTRAL, CINAHL, and the Chinese Biomedical Literature Database, the China National Knowledge Infrastructure, VIP Information, and Wanfang Data databases will be searched from their inception to present. Randomised controlled trials (RCTs) of acupuncture (assessed as the sole treatment or as an adjunct treatment) for chronic neck pain will be included...
2016: Systematic Reviews
A Pilatz, M Boecker, H-C Schuppe, F Wagenlehner
BACKGROUND: Acute epididymitis is an inflammation of the epididymis. It mostly occurs unilaterally and may spread to the testis ('epididymo-orchitis') if untreated. Increasing technological advances allow for an even more detailed examination of concurrent symptoms such as ejaculate changes and the whole spectrum of pathogenic agents, which ranges from sexually transmitted pathogens such as Chlamydia and gonococci to enterobacteria and, rarely, viruses. This review summarises major aspects of the disease including the latest scientific findings...
May 2016: Aktuelle Urologie
Benjamin Rouse, Andrea Cipriani, Qiyuan Shi, Anne L Coleman, Kay Dickersin, Tianjing Li
BACKGROUND: Network meta-analysis compares multiple treatment options for the same condition and may be useful for developing clinical practice guidelines. PURPOSE: To compare treatment recommendations for first-line medical therapy for primary open angle-glaucoma (POAG) from major updates of American Academy of Ophthalmology (AAO) guidelines with the evidence available at the time, using network meta-analysis. DATA SOURCES: MEDLINE, Embase, and the Cochrane Library were searched on 11 March 2014 for randomized, controlled trials (RCTs) of glaucoma monotherapies compared with placebo, vehicle, or no treatment or other monotherapies...
May 17, 2016: Annals of Internal Medicine
Carmine Pinto, Carlo A Barone, Giampiero Girolomoni, Elvio G Russi, Marco C Merlano, Daris Ferrari, Evaristo Maiello
OBJECTIVES: Cetuximab was shown in phase III clinical trials to improve chemotherapy efficacy in patients with advanced colorectal and head-neck cancer. Appropriate management of skin reactions associated with epidermal growth factor receptor inhibitor therapy is necessary to allow adequate drug compliance and to improve patient quality of life and outcomes. METHODS: The RAND/UCLA Appropriateness Method was used by a group of experts to produce new Italian recommendations on the management of skin reactions in this setting...
August 2016: American Journal of Clinical Oncology
Aaron J Buckland, Joseph F Baker, Ryan P Roach, Jeffrey M Spivak
PURPOSE: Cervical disc replacement has become an acceptable alternative to anterior cervical fusion for the surgical treatment of cervical spine spondylosis resulting in radiculopathy or myelopathy following anterior discectomy and decompression. This concise overview considers the current state of knowledge regarding the continued debate of the role of cervical disc replacement with an update in light of the latest clinical trial results. METHODS: A literature review was performed identifying clinical trials pertaining to the use of cervical disc replacement compared to cervical discectomy and fusion...
June 2016: International Orthopaedics
Ben Green, Rui Amaral Mendes, Ruben Van der Valk, Peter A Brennan
There are several novel anticoagulant agents that are being increasingly used as an alternative to warfarin, with these drugs being reported to be at least as effective if not better. Their increased use means that oral care clinicians should have a sound understanding of the mechanism of action, pharmacology, reversal strategies and management of bleeding in patients taking these drugs. Surprisingly, there is little published in the current literature specific to professionals involved in oral health care...
September 2016: Journal of Oral Pathology & Medicine
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