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John V Gahagan, Steven Maximus, Matthew D Whealon, Michael J Phelan, Aram Demirjian, Victor C Joe
The necessity of routine endoscopic retrograde cholangiopancreatography (ERCP) after positive intraoperative cholangiogram (IOC) during laparoscopic cholecystectomy is not well defined. We aimed to examine the incidence of positive IOC among patients who undergo IOC during cholecystectomy and the rate of subsequent ERCP stone extraction. The Nationwide Inpatient Sample database was reviewed for all patients undergoing cholecystectomy with IOC from 2002 to 2012. Patients were then analyzed for ERCP and stone extraction...
October 2016: American Surgeon
Zheng Zhang, Hannah A Ledford, Seojin Park, Wenying Wang, Sassan Rafizadeh, Hyo Jeong Kim, Wilson Xu, Ling Lu, Victor C Lau, Anne A Knowlton, Xiao-Dong Zhang, Ebenezer N Yamoah, Nipavan Chiamvimonvat
The normal function of ion channels depends critically on the precise subcellular localization and the number of channel proteins on the cell surface membrane. Small-conductance, Ca(2+) -activated K(+) channels (SK, KCa 2) are expressed in human atrial myocytes and responsible for shaping atrial action potentials. Understanding the mechanisms of SK channel trafficking may provide new insights into the regulation controlling the repolarization of atrial myocytes. We have previously demonstrated that the C and N termini of SK2 channels interact with actin-binding proteins, α-actinin2 and filamin A, respectively...
October 25, 2016: Journal of Physiology
Yingying Mi, Wen Liu, Ke R Yang, Jianbing Jiang, Qi Fan, Zhe Weng, Yiren Zhong, Zishan Wu, Gary W Brudvig, Victor S Batista, Henghui Zhou, Hailiang Wang
Confining lithium polysulfide intermediates is one of the most effective ways to alleviate the capacity fade of sulfur-cathode materials in lithium-sulfur (Li-S) batteries. To develop long-cycle Li-S batteries, there is an urgent need for material structures with effective polysulfide binding capability and well-defined surface sites; thereby improving cycling stability and allowing study of molecular-level interactions. This challenge was addressed by introducing an organometallic molecular compound, ferrocene, as a new polysulfide-confining agent...
October 25, 2016: Angewandte Chemie
Ana Carolina Coelho Milani, Elis Viviane Hoffmann, Victor Fossaluza, Andrea Parolin Jackowski, Marcelo Feijo Mello
Several studies have recently demonstrated that the volumes of specific brain regions are reduced in children and adolescents with post-traumatic stress disorder (PTSD) compared with those of healthy controls. Our study investigated the potential association between early traumatic experiences and altered brain regions and functions. We conducted a systematic review of the scientific literature regarding functional MRI and a meta-analysis of structural MRI studies that investigated cerebral region volumes in pediatric patients with PTSD...
October 25, 2016: Psychiatry and Clinical Neurosciences
Alain Chichom-Mefire, Victor Mbome Njie, Vincent Verla, Julius Atashili
BACKGROUND: Surgery-related conditions account for the majority of admissions in primary referral hospitals in Sub-Saharan Africa. The role of surgery in the reduction of global disease burden is well recognized, but there is a great qualitative and quantitative disparity in the delivery of surgical and anaesthetic services between countries. This study aims at estimating the nature and volume of surgery delivered in an entire administrative division of Cameroon. METHODS: In this retrospective survey conducted during the year 2013, we used a standard tool to analyse the infrastructure and human resources involved in the delivery of surgical and anaesthetic services in the Fako division in the south-west region of Cameroon...
October 24, 2016: World Journal of Surgery
Mariete B Moreira, Camila F N Da Silva, Rafaela B P Pesci, Victor M Deflon, Sofia Nikolaou
We synthesized and characterized a series of oxo-centered carbonyl-triruthenium complexes with the general formula [Ru3O(CH3COO)6(L)2(CO)], where L = 2,6-dimethylpyrazine (dmpz) (1), isonicotinamide (adpy) (2), 4-acetylpyridine (acpy) (3), 3-methylpyridine (3-pic) (4), 4-methylpyridine (4-pic) (5), 4-tert-butylpyridine (4-tbpy) (6), 4-(dimethyl)aminopyridine (dmap) (7), or 4-aminopyridine (ampy) (8); we also investigated the photoreactivity of these complexes. Single-crystal X-ray diffraction helped to elucidate the structures of 1·H2O, 7·C2H4Cl2, and 8...
October 25, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Rich Boden, Lee P Hutt, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Dimitrios Stamatis, Tatiparthi Reddy, Chew Yee Ngan, Chris Daum, Nicole Shapiro, Victor Markowitz, Natalia Ivanova, Tanja Woyke, Nikos Kyrpides
[This corrects the article DOI: 10.1186/s40793-016-0188-0.].
2016: Standards in Genomic Sciences
Elisabeth Zu Erbach-Schoenberg, Victor A Alegana, Alessandro Sorichetta, Catherine Linard, Christoper Lourenço, Nick W Ruktanonchai, Bonita Graupe, Tomas J Bird, Carla Pezzulo, Amy Wesolowski, Andrew J Tatem
BACKGROUND: Reliable health metrics are crucial for accurately assessing disease burden and planning interventions. Many health indicators are measured through passive surveillance systems and are reliant on accurate estimates of denominators to transform case counts into incidence measures. These denominator estimates generally come from national censuses and use large area growth rates to estimate annual changes. Typically, they do not account for any seasonal fluctuations and thus assume a static denominator population...
2016: Population Health Metrics
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Victor J Del Brutto
BACKGROUND: There is no information on stroke incidence in rural areas of Latin America, where living conditions and cardiovascular risk factors are different from urban centers. AIM: Using a population-based prospective cohort study design, we aimed to assess risk factors influencing stroke incidence in community-dwelling adults living in rural Ecuador. METHODS: First-ever strokes occurring from 1 June 2012 to 31 May 2016, in Atahualpa residents aged ≥40 years, were identified from yearly door-to-door surveys and other overlapping sources...
October 24, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
Daipayan Guha, Raphael Jakubovic, Shaurya Gupta, Naif M Alotaibi, David Cadotte, Leodante B da Costa, Rajeesh George, Chris Heyn, Peter Howard, Anish Kapadia, Jesse M Klostranec, Nicolas Phan, Gamaliel Tan, Todd G Mainprize, Albert Yee, Victor X D Yang
BACKGROUND CONTEXT: Spinal intra-operative computer-assisted navigation (CAN) may guide pedicle screw placement. CAN techniques have been reported to reduce pedicle screw breach rates across all spinal levels. However, definitions of screw breach vary widely across studies, if reported at all. The absolute quantitative error of spinal navigation systems is theoretically a more precise and generalizable metric of navigation accuracy. It has also been computed variably, and reported in fewer than a quarter of clinical studies of CAN-guided pedicle screw accuracy...
October 21, 2016: Spine Journal: Official Journal of the North American Spine Society
N Foray
On the 4th July, 1896, in his medical office of Les Échelles (Savoie, France), Victor Despeignes performed the very first radiotherapy against cancer, documented by indisputable proofs. However, the intellectual and practical approach that leads to this first radiotherapy may appear unexpected to date. Indeed, it is likely that the treatment that Despeignes applied to his neighbour, who did not suffer from stomach cancer, was born with the indirect support of the Lumière brothers, on the basis of a biological theory (the parasitory theory of cancer) that is irrelevant today, with an experimental protocol based on experiments performed on tuberculosis et in a bifractionated model linked by the constraints of a district medical doctor...
October 21, 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Courtney R Kent, Magdalena Bryja, Helen A Gustafson, Margaret Y Kawarski, Gena Lenti, Emily N Pierce, Rachel C Knopp, Victor Ceja, Bhabna Pati, D Eric Walters, Caitlin E Karver
The inflammatory caspases (caspase-1, -4 and -5) are potential therapeutic targets for autoimmune and inflammatory diseases due to their involvement in the immune response upon inflammasome formation. A series of small molecules based on the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold were synthesized with varying substituents on the piperazine ring. Several compounds were pan-selective inhibitors of the inflammatory caspases, caspase-1, -4 and -5, with the ethylbenzene derivative CK-1-41 displaying low nanomolar Ki values across this family of caspases...
October 12, 2016: Bioorganic & Medicinal Chemistry Letters
Emmanuel João Nogueira Leal Silva, Laise Silva Villarino, Victor Talarico Leal Vieira, Thais Accorsi-Mendonça, Henrique Dos Santos Antunes, Gustavo De-Deus, Hélio Pereira Lopes
INTRODUCTION: This study evaluated the bending resistance and cyclic fatigue life of a new single-file reciprocating instrument (Unicone; Medin, Nové Město na Moravě, Czech Republic). Reciproc (VDW, Munich, Germany) and WaveOne (Dentsply Maillefer) instruments were used as references for comparison. METHODS: Flexibility was determined by 45° bending tests using a universal testing machine. The cyclic fatigue test was performed using a custom-made device. For this test, an artificial canal with a 60° angle and a 5-mm radius of curvature was used...
October 21, 2016: Journal of Endodontics
Victor Jebara, Tanous Aoun, Pierre Dahdah, Amine Fikani
No abstract text is available yet for this article.
November 2016: Journal of Vascular Surgery
Virginia Lope, Nerea Fernández de Larrea, Beatriz Pérez-Gómez, Vicente Martín, Victor Moreno, Laura Costas, Federico Longo, José Juan Jiménez-Moleón, Javier Llorca, Nieves Ascunce, Rosana Peiró-Pérez, Jone M Altzibar, Adonina Tardón, Juan Alguacil, Carmen Navarro, Ángeles Sierra, Ana Belén Vega, Amaya Villafañe, Gemma Castaño-Vinyals, Manolis Kogevinas, Marina Pollán, Nuria Aragonés
BACKGROUND: Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors. METHODS: In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province...
2016: PloS One
Alexander Leithner, Alexander Eichner, Jan Müller, Anne Reversat, Markus Brown, Jan Schwarz, Jack Merrin, David J J de Gorter, Florian Schur, Jonathan Bayerl, Ingrid de Vries, Stefan Wieser, Robert Hauschild, Frank P L Lai, Markus Moser, Dontscho Kerjaschki, Klemens Rottner, J Victor Small, Theresia E B Stradal, Michael Sixt
Most migrating cells extrude their front by the force of actin polymerization. Polymerization requires an initial nucleation step, which is mediated by factors establishing either parallel filaments in the case of filopodia or branched filaments that form the branched lamellipodial network. Branches are considered essential for regular cell motility and are initiated by the Arp2/3 complex, which in turn is activated by nucleation-promoting factors of the WASP and WAVE families. Here we employed rapid amoeboid crawling leukocytes and found that deletion of the WAVE complex eliminated actin branching and thus lamellipodia formation...
October 24, 2016: Nature Cell Biology
Ifedayo Victor Ogungbe, William N Setzer
Malaria, leishmaniasis, Chagas disease, and human African trypanosomiasis continue to cause considerable suffering and death in developing countries. Current treatment options for these parasitic protozoal diseases generally have severe side effects, may be ineffective or unavailable, and resistance is emerging. There is a constant need to discover new chemotherapeutic agents for these parasitic infections, and natural products continue to serve as a potential source. This review presents molecular docking studies of potential phytochemicals that target key protein targets in Leishmania spp...
October 19, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Margaret L Pfeiffer, Omar K Ozgur, Jeffrey N Myers, Andrew Peng, Jing Ning, Mark E Zafereo, Sudip Thakar, Bradley Thuro, Victor G Prieto, Merrick I Ross, Bita Esmaeli
BACKGROUND: We sought to update our prior report of findings on sentinel lymph node biopsy (SLNB) and predictors of a positive SLN in patients with conjunctival or eyelid melanoma. METHODS: We reviewed the records of all patients with ocular adnexal melanoma who underwent SLNB at one institution during 2000-2015. We determined rates of positive and false-negative findings on SLNB, primary tumour features correlated with positive findings and rate of nodal recurrence (false-negative event) after negative findings...
October 24, 2016: Acta Ophthalmologica
Guillermo Cásedas, Francisco Les, Maria Pilar Gómez-Serranillos, Carine Smith, Víctor López
Sour cherry juice (Prunus cerasus) is consumed as a nutritional supplement claiming health effects. The aim of the study was to evaluate the different properties of sour cherry juice in terms of antioxidant activity and inhibition of target enzymes in the central nervous system and diabetes. The content of polyphenols and anthocyanins was quantified. Different experiments were carried out to determine the radical scavenging properties of the juice. The activity of sour cherry juice was also tested in physiological relevant enzymes of the central nervous system (acetylcholinesterase, monoamine oxidase A, tyrosinase) and others involved in type 2 diabetes (α-glucosidase, dipeptidyl peptidase-4)...
October 24, 2016: Food & Function
Tommy C Y Chan, Alex Lk Ng, George P M Cheng, Zheng Wang, Victor C P Woo, Vishal Jhanji
We compared the visual and refractive outcomes between 2 different incisional sites in small incision lenticule extraction (SMILE) for low myopic astigmatism. This was a contralateral eye study. Consecutive cases that underwent bilateral SMILE surgery were included. Procedures for both eyes were identical apart from the location of opening incision. The incision was set on the temporal side for the right eye (Group 1), while a superior incision was set for the left eye (Group 2). Twenty-nine patients with a mean age of 35...
October 24, 2016: Scientific Reports
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