keyword
https://read.qxmd.com/read/38718139/2024-aha-acc-amssm-hrs-paces-scmr-guideline-for-the-management-of-hypertrophic-cardiomyopathy-a-report-of-the-american-heart-association-american-college-of-cardiology-joint-committee-on-clinical-practice-guidelines
#1
REVIEW
Steve R Ommen, Carolyn Y Ho, Irfan M Asif, Seshadri Balaji, Michael A Burke, Sharlene M Day, Joseph A Dearani, Kelly C Epps, Lauren Evanovich, Victor A Ferrari, José A Joglar, Sadiya S Khan, Jeffrey J Kim, Michelle M Kittleson, Chayakrit Krittanawong, Matthew W Martinez, Seema Mital, Srihari S Naidu, Sara Saberi, Christopher Semsarian, Sabrina Times, Cynthia Burstein Waldman
AIM: The "2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy" provides recommendations to guide clinicians in the management of patients with hypertrophic cardiomyopathy. METHODS: A comprehensive literature search was conducted from September 14, 2022, to November 22, 2022, encompassing studies, reviews, and other evidence on human subjects that were published in English from PubMed, EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline...
May 8, 2024: Circulation
https://read.qxmd.com/read/38718138/persistent-gdnf-expression-45%C3%A2-months-after-putaminal-infusion-of-aav2-gdnf-in-a-patient-with-parkinson-s-disease
#2
JOURNAL ARTICLE
John D Heiss, Abhik Ray-Chaudhury, David E Kleiner, Debra J Ehrlich, Gretchen Scott, Nancy A Edwards, David S Goldstein, Dima A Hammoud, Piotr Hadaczek, Victor S Van Laar, Shantelle A Graff, Peter Herscovitch, Codrin Lungu, Mark Hallett, Russell R Lonser, Kareem A Zaghloul, Krystof S Bankiewicz
OBJECTIVE: Gene therapy by convection-enhanced delivery of type 2 adeno-associated virus-glial cell derived neurotrophic factor (AAV2-GDNF) to the bilateral putamina seeks to increase GDNF gene expression and treat Parkinson's disease (PD). METHODS: A 63-year-old man with advanced PD received AAV2-GDNF in a clinical trial. He died from pneumonia after anterior cervical discectomy and fusion 45 months later. An autopsy included brain examination for GDNF transgene expression...
May 8, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38717910/-analysis-of-macular-pigment-optical-density-in-childhood-a-systematic-review
#3
REVIEW
Víctor Ponce-García, María-José Bautista-Llamas, Marta-C García-Romera
PURPOSE: This systematic review studies the relationship between Macular Pigment Optical Density (MPOD) values and cognitive and visual function in childhood. METHODS: It included cross-sectional, observational studies or controlled clinical trials in humans between 0 and 18 years of age, analyzing MPOD values in 3 main databases: PubMed, Scopus and Web of Science. The study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations...
May 8, 2024: Seminars in Ophthalmology
https://read.qxmd.com/read/38717752/keratosis-pilaris-like-reaction-associated-with-chromatin-remodeling-complex-inhibition-in-uveal-melanoma
#4
JOURNAL ARTICLE
Riyad N H Seervai, Madison M Taylor, Ziba Rahbar, Sapna P Patel, Kelly C Nelson, Victor G Prieto, Jonathan L Curry
No abstract text is available yet for this article.
May 8, 2024: JAMA Dermatology
https://read.qxmd.com/read/38717630/cardiac-biomarkers-for-diagnosing-takotsubo-syndrome
#5
JOURNAL ARTICLE
Victor Schweiger, Davide Di Vece, Victoria L Cammann, Iva Koleva, Michael Würdinger, Thomas Gilhofer, Katja Rajman, Konrad A Szawan, David Niederseer, Rodolfo Citro, Carmine Vecchione, Eduardo Bossone, Sebastiano Gili, Michael Neuhaus, Jennifer Franke, Benjamin Meder, Miłosz Jaguszewski, Michel Noutsias, Maike Knorr, Thomas Jansen, Fabrizio D'Ascenzo, Francesco Bruno, Ovidio De Filippo, Giulio Stefanini, Gianluca Campo, Wojciech Wanha, Sergio Raposeiras Roubin, Wolfgang Dichtl, Dirk von Lewinski, Christof Burgdorf, Behrouz Kherad, Carsten Tschöpe, Annahita Sarcon, Jerold Shinbane, Lawrence Rajan, Guido Michels, Roman Pfister, Alessandro Cuneo, Claudius Jacobshagen, Mahir Karakas, Wolfgang Koenig, Alexander Pott, Philippe Meyer, Marco Roffi, Adrian Banning, Mathias Wolfrum, Florim Cuculi, Richard Kobza, Thomas A Fischer, Tuija Vasankari, K E Juhani Airaksinen, L Christian Napp, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Christina Chan, Paul Bridgman, Daniel Beug, Clément Delmas, Olivier Lairez, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, Ibrahim El-Battrawy, Ibrahim Akin, Karolina Poledniková, Petr Toušek, David E Winchester, Michael Massoomi, Jan Galuszka, Christian Ukena, Gregor Poglajen, Pedro Carrilho-Ferreira, Christian Hauck, Carla Paolini, Claudio Bilato, Yoshio Kobayashi, Ken Kato, Iwao Ishibashi, Toshiharu Himi, Jehangir Din, Ali Al-Shammari, Abhiram Prasad, Charanjit S Rihal, Kan Liu, P Christian Schulze, Matteo Bianco, Lucas Jörg, Hans Rickli, Gonçalo Pestana, Thanh H Nguyen, Michael Böhm, Lars S Maier, Fausto J Pinto, Petr Widimský, Stephan B Felix, Ruediger C Braun-Dullaeus, Wolfgang Rottbauer, Gerd Hasenfuß, Burkert M Pieske, Heribert Schunkert, Monika Budnik, Grzegorz Opolski, Holger Thiele, Johann Bauersachs, John D Horowitz, Carlo Di Mario, William Kong, Mayank Dalakoti, Yoichi Imori, Thomas Münzel, Jeroen J Bax, Thomas F Lüscher, Filippo Crea, Frank Ruschitzka, Jelena R Ghadri, Christian Templin
No abstract text is available yet for this article.
May 8, 2024: European Heart Journal
https://read.qxmd.com/read/38717396/intermittent-like-synchronization-and-desynchronization-phenomena-in-a-colpitts-network-model
#6
JOURNAL ARTICLE
Victor E Camargo, Patrick Louodop, Hilda A Cerdeira, Fernando F Ferreira
This study investigates the dynamics of a modified Colpitts oscillator, exhibiting complex periodic and chaotic behaviors. Our research explores the dynamics and synchronization of coupled chaotic Colpitts oscillators, crucial for understanding their potential applications and behaviors. The main discovery is the emergence of a phase in which the systems achieve either complete synchronization or desynchronization. This behavior depends on the values of the coupling parameter. The subsequent challenge involves understanding how the coupling parameter influences the emergence of this synchronization phenomenon...
May 1, 2024: Chaos
https://read.qxmd.com/read/38717362/epigenetic-reprogramming-of-h3k4me3-in-adipose-derived-stem-cells-by-hfs-diet-consumption-leads-to-a-disturbed-transcriptomic-profile-in-adipocytes
#7
JOURNAL ARTICLE
Berenice Pérez, Ivan Torre-Villalvazo, Marti Wilson-Verdugo, Dana Lau-Corona, Erick Muciño-Olmos, Diana Coutiño-Hernandez, Lilia Noriega-Lopez, Osbaldo Resendis-Antonio, Victor Julian Valdes, Nimbe Torres, Armando R Tovar
Adipose tissue metabolism is actively involved in the regulation of energy balance. Adipose-derived stem cells (ASCs) play a critical role in maintaining adipose tissue function through their differentiation into mature adipocytes. This study aimed to investigate the impact of an obesogenic environment on the epigenetic landscape of ASCs and its impact on adipocyte differentiation and its metabolic consequences. Our results showed that ASCs from rats on a high-fat sucrose (HFS) diet displayed reduced adipogenic capacity, increased fat accumulation, and formed larger adipocytes compared to the control (C) group...
May 8, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38717138/lateral-transorbital-endoscope-assisted-resection-of-anterior-temporal-lobe-neoplasm-2-dimensional-operative-video
#8
JOURNAL ARTICLE
Rupen Desai, Victor Ramzes Chavez-Herrera, Steven Zeldin, Gulce Gel, Kyle J Godfrey, Theodore H Schwartz
Transorbital neuroendoscopic surgery (TONES) is a minimally invasive approach, providing excellent access to extradural pathology of the sphenoid wing, orbital apex, Meckel's cave, and lateral cavernous sinus.1-10 Few cases of intradural pathology, such as gliomas or epileptic foci of the temporal lobe, have been described, apart from cadaveric anatomic studies.11-13 In this video, we present the case of a 63-year-old man with first time seizure. MRI demonstrated a fluid-attenuated inversion recovery hyperintense, noncontrast enhancing medial temporal lobe lesion consistent with low grade glioma...
May 8, 2024: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/38716989/acute-myocarditis-as-the-initial-presentation-of-desmoplakin-mutation-broadening-the-differential-diagnosis
#9
JOURNAL ARTICLE
Hideki Koike, Amr Idris, Justin Berger, Victor Y Cheng, Jay Sengupta, João L Cavalcante
No abstract text is available yet for this article.
April 2024: Arquivos Brasileiros de Cardiologia
https://read.qxmd.com/read/38716901/amine-adducts-of-triallylborane-as-highly-reactive-allylborating-agents-for-cu-i-catalyzed-allylation-of-chiral-sulfinylimines
#10
JOURNAL ARTICLE
Michael S Alexeev, Tatiana V Strelkova, Michael M Ilyin, Yulia V Nelyubina, Ivan A Bespalov, Michael G Medvedev, Victor N Khrustalev, Nikolai Yu Kuznetsov
The implementation of selective catalytic processes with highly active reagents is an attractive strategy that meets the modern principles of sustainable development of chemistry. In the current study, we for the first time describe the method and general principles of Cu(I)-catalyzed allylation of imines with amine adducts of allylic triorganoboranes. Triallylborane is an extremely reactive compound and cannot be used for the catalytic allylation of imines, whereas its amine adducts are ideal substrates for catalysis...
May 8, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38716577/enabling-white-color-tunability-in-complex-3d-printed-composites-by-using-lead-free-self-trapped-exciton-2d-perovskite-carbon-quantum-dot-inks
#11
JOURNAL ARTICLE
Tawanwit Luangwanta, Silver-Hamil Turren-Cruz, Sofia Masi, Samrat Das Adhikari, Ileana B Recalde, Marcileia Zanatta, Diego Iglesias, Jhonatan Rodríguez-Pereira, Santi Gené-Marimon, Eugenia Martinez-Ferrero, Sulawan Kaowphong, Emilio Palomares, Victor Sans, Andrés F Gualdrón-Reyes, Iván Mora-Seró
The generation of stable white light emission using lead-free perovskites remains a huge challenge in the development of future display and lighting technologies, due to fast material deterioration and the decrease of the color quality. In this work, we report a combination of diverse types of 2D A2 SnX4 (A = bulky cation, X = Br, I) perovskites exhibiting self-trapped exciton (STE) emission and blue luminescent carbon quantum dots (CQDs), with the purpose of generating A2 SnX4 /CQD inks with a broadband emission in the visible region and a tunable white light color...
May 8, 2024: Nanoscale
https://read.qxmd.com/read/38716475/temperature-sensitivity-of-14-n-v-and-15-n-v-ground-state-manifolds
#12
JOURNAL ARTICLE
Sean Lourette, Andrey Jarmola, Victor M Acosta, A Glen Birdwell, Dmitry Budker, Marcus W Doherty, Tony Ivanov, Vladimir S Malinovsky
We measure electron- and nuclear-spin transition frequencies in the ground state of nitrogen-vacancy (N- V ) centers in diamond for two nitrogen isotopes (14 N- V and 15 N- V ) over temperatures ranging from 77 to 400 K. Measurements are performed using Ramsey interferometry and direct optical readout of the nuclear and electron spins. We extract coupling parameters Q (for 14 N- V ), D , A ‖ , A ⊥ , and <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msub><mml:mrow><mml:mi>γ</mml:mi></mml:mrow><mml:mrow><mml:mi>e</mml:mi></mml:mrow></mml:msub><mml:mo>/</mml:mo><mml:msub><mml:mrow><mml:mi>γ</mml:mi></mml:mrow><mml:mrow><mml:mi>n</mml:mi></mml:mrow></mml:msub></mml:math>, and their temperature dependences for both isotopes...
June 2023: Physical Review Applied
https://read.qxmd.com/read/38716072/-moringa-oleifera-based-feed-supplement-protects-against-renal-ischaemia-reperfusion-injury-via-downregulation-of-bax-caspase-3-signaling
#13
JOURNAL ARTICLE
Oladele A Afolabi, Tunmise M Akhigbe, Sodiq O Hammed, Moses A Hamed, Victor O Ekundina, Richard A Ajike, Babatunde A Alabi, Roland E Akhigbe
INTRODUCTION: Ischaemia/reperfusion (I/R) may lead to acute kidney injury via the induction of oxidative stress. On the other hand, Moringa oleifera has been reported to exert antioxidant activities. This study was designed to assess whether or not Moringa oleifera-based feed supplement could prevent I/R-induced renal injury. MATERIALS AND METHODS: Renal I/R was induced by occluding the right renal artery for 30  min followed by a 2-h reperfusion. RESULTS: Renal I/R led to increased absolute renal weight and renal organo-somatic weight index...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38715798/surrogate-indices-of-insulin-resistance-using-the-matsuda-index-as-reference-in-adult-men-a-computational-approach
#14
JOURNAL ARTICLE
Víctor Antonio Malagón-Soriano, Andres Julian Ledezma-Forero, Cristian Felipe Espinel-Pachon, Álvaro Javier Burgos-Cárdenas, Maria Fernanda Garces, Gustavo Eduardo Ortega-Ramírez, Roberto Franco-Vega, Jhon Jairo Peralta-Franco, Luis Miguel Maldonado-Acosta, Jorge Andres Rubio-Romero, Manuel Esteban Mercado-Pedroza, Sofia Alexandra Caminos-Cepeda, Ezequiel Lacunza, Carlos Armando Rivera-Moreno, Aquiles Enrique Darghan-Contreras, Ariel Iván Ruiz-Parra, Jorge E Caminos
BACKGROUND: Overweight and obesity, high blood pressure, hyperglycemia, hyperlipidemia, and insulin resistance (IR) are strongly associated with non-communicable diseases (NCDs), including type 2 diabetes, cardiovascular disease, stroke, and cancer. Different surrogate indices of IR are derived and validated with the euglycemic-hyperinsulinemic clamp (EHC) test. Thus, using a computational approach to predict IR with Matsuda index as reference, this study aimed to determine the optimal cutoff value and diagnosis accuracy for surrogate indices in non-diabetic young adult men...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38715423/tracheostomy-in-patients-with-acute-myocardial-infarction-and-respiratory-failure
#15
JOURNAL ARTICLE
Megan Grammatico, Soumya Banna, Andi Shahu, Maria Gabriela Gastanadui, Jose Victor Jimenez, Cory Heck, Abner Arias-Olson, Alexander Thomas, Tariq Ali, P Elliott Miller
OBJECTIVE: Patients with acute myocardial infarction (AMI) complicated by respiratory failure require antiplatelet regimens which often cannot be stopped and may increase bleeding from tracheostomy. However, there is limited available data on both the proportion of patients undergoing tracheostomy and the impact on antiplatelet regimens on outcomes. METHODS: Utilizing the Vizient® Clinical Data Base, we identified patients ≥18 years admitted from 2015 to 2019 with a primary diagnosis of AMI and requiring invasive mechanical ventilation (IMV)...
May 7, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38715410/does-intraoperative-extracochlear-electrocochleography-correlate-with-postoperative-audiometric-hearing-thresholds-in-cochlear-implant-surgery-a-retrospective-analysis-of-cochlear-monitoring
#16
JOURNAL ARTICLE
Sabine Haumann, Marlene Mynarek Née Bradler, Hannes Maier, Victor Helmstaedter, Andreas Büchner, Thomas Lenarz, Magnus J Teschner
In recent years, tools for early detection of irreversible trauma to the basilar membrane during hearing preservation cochlear implant (CI) surgery were established in several clinics. A link with the degree of postoperative hearing preservation in patients was investigated, but patient populations were usually small. Therefore, this study's aim was to analyze data from intraoperative extracochlear electrocochleography (ECochG) recordings for a larger group.During hearing preservation CI surgery, extracochlear recordings were made before, during, and after CI electrode insertion using a cotton wick electrode placed at the promontory...
2024: Trends in Hearing
https://read.qxmd.com/read/38715405/neurodevelopmental-outcome-in-preterm-infants-with-intraventricular-hemorrhages-the-potential-of-quantitative-brainstem-mri
#17
JOURNAL ARTICLE
Patric Kienast, Victor Schmidbauer, Mehmet Salih Yildirim, Selina Seeliger, Marlene Stuempflen, Julia Elis, Vito Giordano, Renate Fuiko, Monika Olischar, Klemens Vierlinger, Christa Noehammer, Angelika Berger, Daniela Prayer, Gregor Kasprian, Katharina Goeral
OBJECTIVES: This retrospective study aimed to identify quantitative magnetic resonance imaging markers in the brainstem of preterm neonates with intraventricular hemorrhages. It delves into the intricate associations between quantitative brainstem magnetic resonance imaging metrics and neurodevelopmental outcomes in preterm infants with intraventricular hemorrhage, aiming to elucidate potential relationships and their clinical implications. MATERIALS AND METHODS: Neuroimaging was performed on preterm neonates with intraventricular hemorrhage using a multi-dynamic multi-echo sequence to determine T1 relaxation time, T2 relaxation time, and proton density in specific brainstem regions...
May 2, 2024: Cerebral Cortex
https://read.qxmd.com/read/38715366/prevalence-of-frailty-phenotypes-in-older-people-living-with-hiv-a-cross-sectional-study-from-brazil
#18
JOURNAL ARTICLE
Susana Lilian Wiechmann, Alexandre Mestre Tejo, Manuel Victor Silva Inácio, Arthur Eumann Mesas, Marcos Aparecido Sarria Cabrera
BACKGROUND: Frailty may affect people living with HIV (PLHIV) prematurely. Fried's frailty phenotype, composed of 5 criteria, is one of the most used instruments for its assessment. This study aimed to determine the prevalence of these criteria among PLHIV classified as prefrail and frail in Brazil. METHODS: A cross-sectional study analyzed the prevalence of the Frailty Phenotype in Brazil with 670 individuals aged ≥ 50 years and undetectable viral load...
2024: Journal of the International Association of Providers of AIDS Care
https://read.qxmd.com/read/38715109/a-healthcare-claims-analysis-to-identify-and-characterize-patients-with-suspected-x-linked-myotubular-myopathy-xlmtm-in-the-brazilian-healthcare-system
#19
JOURNAL ARTICLE
Paulo Victor Sgobbi Souza, Tmirah Haselkorn, Jader Baima, Renato Watanabe Oliveira, Fabián Hernández, Marina G Birck, Marcondes C França
BACKGROUND: X-linked myotubular myopathy (XLMTM) is a rare, life-threatening congenital disease, which is not well-defined. To our knowledge, no studies characterizing the XLMTM disease burden have been conducted in Brazil. We identified and described patients with suspected XLMTM using administrative claims data from the Brazilian public healthcare system. METHODS: Data from 2015 to 2019 were extracted from the DATASUS database. As no XLMTM-specific ICD-10 code was available, a stepwise algorithm was applied to identify patients with suspected XLMTM by selecting male patients with a congenital myopathies code (G71...
May 7, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38714872/a-mega-rna-editing-tool
#20
JOURNAL ARTICLE
Victor Tieu
No abstract text is available yet for this article.
May 7, 2024: Nature Reviews. Cancer
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