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https://www.readbyqxmd.com/read/28350894/assessing-the-amount-of-spontaneous-real-world-spoken-language-in-aphasia-validation-of-two-methods
#1
Michelle M Haddad, Edward Taub, Gitendra Uswatte, Margaret L Johnson, Victor W Mark, Ameen Barghi, Ezekiel Byrom, Xiaohua Zhou, Christina M Rodriguez
Purpose: The purpose of this article is to present the results of a study evaluating the psychometric properties of 2 new measures that exclusively assess the amount of real-world spoken language in patients with aphasia. Method: Forty individuals with aphasia were evaluated on several measures of spoken language in real-world settings. The Verbal Activity Log (VAL; Johnson et al., 2014) has participants, aided by caregivers, indicate current amount and quality of real-world spoken language compared with before stroke...
March 28, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28350752/the-yield-of-endoscopic-investigation-for-unintentional-weight-loss
#2
Naim Abu-Freha, Yotam Lior, Shira Shoher, Victor Novack, Alexander Fich, Alexander Rosenthal, Ohad Etzion
AIM: The aim of this study was to assess the yield of endoscopic evaluation in isolated unintentional weight loss (UWL) patients compared with patients with weight loss and additional symptoms or signs. PATIENTS AND METHODS: A retrospective review of all patients who underwent an endoscopic evaluation for the investigation of UWL at Soroka University Medical Center between 2006 and 2012. Data on clinical indication, endoscopic, and laboratory finding were retrieved...
May 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28350742/short-article-impact-of-genetic-variation-in-the-vasopressin-1a-receptor-on-the-development-of-organ-failure-in-patients-admitted-for-acute-decompensation-of-liver-cirrhosis
#3
Annarein J C Kerbert, Jelte J Schaapman, Johan J van der Reijden, Àlex Amorós Navarro, Aiden McCormick, Bart van Hoek, Vicente Arroyo, Pere Ginès, Rajiv Jalan, Victor Vargas, Rudolf Stauber, Hein W Verspaget, Minneke J Coenraad
BACKGROUND: Vasopressin receptor-mediated vasoconstriction is considered to be involved in the pathogenesis of organ failure in acute-on-chronic liver failure (ACLF). PATIENTS AND METHODS: We studied the association between six single nucleotide polymorphisms (SNPs) of the vasopressin 1a receptor gene and the development of organ failure in 826 patients admitted for acute decompensation of liver cirrhosis (n=641) or ACLF (n=185). RESULTS: No associations were found for SNPs with the presence of circulatory or renal failure...
May 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28346870/-to-the-victor-go-the-spoils-infants-expect-resources-to-align-with-dominance-structures
#4
Elizabeth A Enright, Hyowon Gweon, Jessica A Sommerville
Previous research has found that within the first year of life infants possess rich knowledge about social structures (i.e., that some individuals are dominant over other individuals) as well as expectations about resource distributions (i.e., that resources are typically distributed equally to recipients). We investigated whether infants' expectations about resource distribution can be modulated by information about the dominance structure between the recipients. We first replicated the finding that infants attribute a stable dominance hierarchy to a pair of individuals when their goals conflicted and one individual yielded to the other (Expt...
March 24, 2017: Cognition
https://www.readbyqxmd.com/read/28346013/the-physiology-of-blood-loss-and-shock-new-insights-from-a-human-laboratory-model-of-hemorrhage
#5
Alicia M Schiller, Jeffrey T Howard, Victor A Convertino
The ability to quickly diagnose hemorrhagic shock is critical for favorable patient outcomes. Therefore, it is important to understand the time course and involvement of the various physiological mechanisms that are active during volume loss and that have the ability to stave off hemodynamic collapse. This review provides new insights about the physiology that underlies blood loss and shock in humans through the development of a simulated model of hemorrhage using lower body negative pressure. In this review, we present controlled experimental results through utilization of the lower body negative pressure human hemorrhage model that provide novel insights on the integration of physiological mechanisms critical to the compensation for volume loss...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28345211/3d-echocardiographic-analysis-of-aortic-annulus-for-transcatheter-aortic-valve-replacement-using-novel-aortic-valve-quantification-software-comparison-with-computed-tomography
#6
Anuj Mediratta, Karima Addetia, Diego Medvedofsky, Robert J Schneider, Eric Kruse, Atman P Shah, Sandeep Nathan, Jonathan D Paul, John E Blair, Takeyoshi Ota, Husam H Balkhy, Amit R Patel, Victor Mor-Avi, Roberto M Lang
BACKGROUND: With the increasing use of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS), computed tomography (CT) remains the standard for annulus sizing. However, 3D transesophageal echocardiography (TEE) has been an alternative in patients with contraindications to CT. We sought to (1) test the feasibility, accuracy, and reproducibility of prototype 3DTEE analysis software (Philips) for aortic annular measurements and (2) compare the new approach to the existing echocardiographic techniques...
March 27, 2017: Echocardiography
https://www.readbyqxmd.com/read/28344888/pre-emptive-and-therapeutic-adoptive-immunotherapy-for-nasopharyngeal-carcinoma-phenotype-and-effector-function-of-t-cells-impact-on-clinical-response
#7
Corey Smith, Victor Lee, Andrea Schuessler, Leone Beagley, Sweera Rehan, Janice Tsang, Vivian Li, Randal Tiu, David Smith, Michelle A Neller, Katherine K Matthews, Emma Gostick, David A Price, Jacqueline Burrows, Glen M Boyle, Daniel Chua, Benedict Panizza, Sandro V Porceddu, John Nicholls, Dora Kwong, Rajiv Khanna
Adoptive T cell therapy has emerged as a powerful strategy to treat human cancers especially haematological malignancies. Extension of these therapies to solid cancers remains a significant challenge especially in the context of defining immunological correlates of clinical responses. Here we describe results from a clinical study investigating autologous Epstein-Barr virus (EBV)-specific T cells generated using a novel AdE1-LMPpoly vector to treat patients with nasopharyngeal carcinoma (NPC) either pre-emptively in at-risk patients with no or minimal residual disease (N/MRD) or therapeutically in patients with active recurrent/metastatic disease (ARMD)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28344765/new-insights-on-thyroid-hormone-mediated-regulation-of-herpesvirus-infections
#8
REVIEW
Robert W Figliozzi, Feng Chen, S Victor Hsia
Thyroid hormone (T3) has been suggested to participate in the regulation of herpesvirus replication during reactivation. Clinical observations and in vivo experiments suggest that T3 are involved in the suppression of herpes virus replication. In vitro, differentiated LNCaP cells, a human neuron-like cells, further resisted HSV-1 replication upon addition of T3. Previous studies indicate that T3 controlled the expression of several key viral genes via its nuclear receptors in differentiated LNCaP cells. Additional observation showed that differentiated LNCaP cells have active PI3K signaling and inhibitor LY294002 can reverse T3-mediated repression of viral replication...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28344683/dispositional-mindfulness-predicts-adaptive-affective-responses-to-health-messages-and-increased-exercise-motivation
#9
Yoona Kang, Matthew Brook O'Donnell, Victor J Strecher, Emily B Falk
Feelings can shape how people respond to persuasive messages. In health communication, adaptive affective responses to potentially threating messages constitute one key to intervention success. The current study tested dispositional mindfulness, characterized by awareness of the present moment, as a predictor of adaptive affective responses to potentially threatening health messages and desirable subsequent health outcomes. Both general and discrete negative affective states (i.e., shame) were examined in relation to mindfulness and intervention success...
April 2017: Mindfulness
https://www.readbyqxmd.com/read/28344592/dysbindin-deficiency-modifies-the-expression-of-gaba-neuron-and-ion-permeation-transcripts-in-the-developing-hippocampus
#10
Jennifer Larimore, Stephanie A Zlatic, Miranda Arnold, Kaela S Singleton, Rebecca Cross, Hannah Rudolph, Martha V Bruegge, Andrea Sweetman, Cecilia Garza, Eli Whisnant, Victor Faundez
The neurodevelopmental factor dysbindin is required for synapse function and GABA interneuron development. Dysbindin protein levels are reduced in the hippocampus of schizophrenia patients. Mouse dysbindin genetic defects and other mouse models of neurodevelopmental disorders share defective GABAergic neurotransmission and, in several instances, a loss of parvalbumin-positive interneuron phenotypes. This suggests that mechanisms downstream of dysbindin deficiency, such as those affecting GABA interneurons, could inform pathways contributing to or ameliorating diverse neurodevelopmental disorders...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28344560/nitric-oxide-has-a-concentration-dependent-effect-on-the-cell-cycle-acting-via-ein2-in-arabidopsis-thaliana-cultured-cells
#11
Galina V Novikova, Luis A J Mur, Alexander V Nosov, Artem A Fomenkov, Kirill S Mironov, Anna S Mamaeva, Evgeny S Shilov, Victor Y Rakitin, Michael A Hall
Ethylene is known to influence the cell cycle (CC) via poorly characterized roles whilst nitric oxide (NO) has well-established roles in the animal CC but analogous role(s) have not been reported for plants. As NO and ethylene signaling events often interact we examined their role in CC in cultured cells derived from Arabidopsis thaliana wild-type (Col-0) plants and from ethylene-insensitive mutant ein2-1 plants. Both NO and ethylene were produced mainly during the first 5 days of the sub-cultivation period corresponding to the period of active cell division...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28344414/three-dimensional-echocardiography-current-status-and-real-life-applications
#12
REVIEW
Victor Chien-Chia Wu, Masaaki Takeuchi
The use of cardiac ultrasound is fundamental to the understanding of normal heart function and crucial to pathophysiological diagnosis. The growing availability of 3D echocardiography (3DE) over the last decade has allowed its applications to expand from establishing reference values for chamber size and elucidating ventricular mechanics, to assessing valvular disease severity and playing pivotal roles in interventional procedures. Several important advantages of 3DE include eliminating geometric assumptions, quantifying complex geometric shape volumes, viewing structures from any perspective, assessing lesion in simultaneous multiplanes or multislice mode, all of which are not possible with traditional 2D echocardiography (2DE)...
March 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28344091/determination-of-structural-and-thermodynamic-parameters-of-bovine-%C3%AE-trypsin-isoform-in-aqueous-organic-media
#13
Dayanne Pinho Rosa, Evaldo Vitor Pereira, Antonio Victor Baioco Vasconcelos, Maria Aparecida Cicilini, André Romero da Silva, Caroline Dutra Lacerda, Jamil Silvano de Oliveira, Marcelo Matos Santoro, Juliana Barbosa Coitinho, Alexandre Martins Costa Santos
The α-trypsin isoform is a globular protein that belongs to serine-protease family and has a polypeptide chain of 223 amino acid residues, six disulfide bridges and two domains with similar structures. The effects of aqueous-organic solvent (ethanol) in different concentration on the α-trypsin structure have been investigated by spectroscopic techniques and thermodynamic data analysis. The results from spectroscopic measurements, including far-UV Circular Dichroism, UV-vis absorption spectroscopy, intrinsic tryptophan fluorescence and dynamic light scattering (DLS) suggest the formation of partially folded states, instead of aggregate states, at high ethanol concentration (>60% v/v ethanol), with little loss of secondary structure, but with significant tertiary structure changes...
March 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28343999/a-genome-wide-analysis-of-human-pluripotent-stem-cell-derived-endothelial-cells-in-2d-or-3d-culture
#14
Jue Zhang, Michael P Schwartz, Zhonggang Hou, Yongsheng Bai, Hamisha Ardalani, Scott Swanson, John Steill, Victor Ruotti, Angela Elwell, Bao Kim Nguyen, Jennifer Bolin, Ron Stewart, James A Thomson, William L Murphy
A defined protocol for efficiently deriving endothelial cells from human pluripotent stem cells was established and vascular morphogenesis was used as a model system to understand how synthetic hydrogels influence global biological function compared with common 2D and 3D culture platforms. RNA sequencing demonstrated that gene expression profiles were similar for endothelial cells and pericytes cocultured in polyethylene glycol (PEG) hydrogels or Matrigel, while monoculture comparisons identified distinct vascular signatures for each cell type...
March 10, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28343902/stepwise-strategies-to-successfully-recruit-diabetes-patients-in-a-large-research-study-in-mexican-population
#15
Niels H Wacher, Mario Reyes-Sánchez, Héctor Raúl Vargas-Sánchez, Mireya Gamiochipi-Cano, Ramón Alberto Rascón-Pacheco, Rita A Gómez-Díaz, Svetlana V Doubova, Adán Valladares-Salgado, Martha Catalina Sánchez-Becerra, Araceli Méndez-Padrón, Leticia A Valdez-González, Rafael Mondragón-González, Miguel Cruz, Ana María Salinas-Martinez, María Guadalupe Garza-Sagástegui, Jaime Hernández-Rubí, Arturo González-Hermosillo, Víctor H Borja-Aburto
AIMS: Describe stepwise strategies (electronic chart review, patient preselection, call-center, personnel dedicated to recruitment) for the successful recruitment of >5000 type 2 diabetes patients in four months. METHODS: Twenty-five family medicine clinics from Mexico City and the State of Mexico participated: 13 usual care, 6 specialized diabetes care and 6 chronic disease care. Appointments were scheduled from 11/3/2015 to 3/31/2016. Phone calls were generated automatically from an electronic database...
March 23, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28343484/culture-of-healthcare-safety-and-quality-challenges-for-nursing-practice
#16
Víctor Reyes Alcázar
No abstract text is available yet for this article.
March 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28343254/dynamic-measurements-of-cervical-neural-foramina-during-neck-movements-in-asymptomatic-young-volunteers
#17
Victor Chang, Azam Basheer, Timothy Baumer, Daniel Oravec, Colin P McDonald, Michael J Bey, Stephen Bartol, Yener N Yeni
PURPOSE: Neural foraminal dimensions are considered important in nerve root compression and development of cervical radiculopathy, but baseline data regarding their range during normal motion are not available. An in vivo study of cervical foraminal motion was conducted to characterize normal 3D dynamic foraminal dimensions during physiological neck motion and compare between different tasks and intervertebral segments. METHODS: Biplane X-ray imaging and computed tomography-based markerless tracking were used to measure foraminal height (FH) and width (FW) from five asymptomatic subjects during neck axial rotation and extension...
March 25, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28343221/abandoning-prophylactic-abdominal-drainage-after-hepatic-surgery-10-years-of-no-drain-policy-in-an-enhanced-recovery-after-surgery-environment
#18
Edgar M Wong-Lun-Hing, Victor van Woerden, Toine M Lodewick, Marc H A Bemelmans, Steven W M Olde Damink, Cornelis H C Dejong, Ronald M van Dam
BACKGROUND: Routine prophylactic abdominal drainage after hepatic surgery is still being debated, as it may be unnecessary, possibly harmful, and uncomfortable for patients. This study evaluated the safety of a no-drain policy after liver resection within an Enhanced Recovery after Surgery (ERAS) programme. METHODS: All hepatectomies performed without prophylactic drainage during 2005-2014 were included. Primary end points were resection-surface-related (RSR) morbidity, defined as the presence of postoperative biloma, hemorrhage or abscess, and reinterventions...
March 25, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28343035/evaluation-of-4-methylcyclohexanemethanol-mchm-in-a-combined-irritatancy-and-local-lymph-node-assay-llna-in-mice
#19
Victor J Johnson, Scott S Auerbach, Michael I Luster, Suramya Waidyanatha, Scott A Masten, Mary S Wolfe, Florence G Burleson, Gary R Burleson, Dori R Germolec
4-Methylcyclohexanemethanol (MCHM) is a flotation reagent used in fine coal beneficiation. On January 9, 2014, crude MCHM, a mixture containing predominantly MCHM, was inadvertently released into the Elk River, a municipal water source that serves about 300,000 people in the Charleston, WV area, resulting in temporary contamination of 15 percent of the state's tap water and causing significant dermal exposure. The current studies were undertaken to determine whether crude MCHM or MCHM has the potential to produce dermal irritancy and/or sensitization...
March 22, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28342994/persistent-organic-pollutants-pops-in-the-atmosphere-of-coastal-areas-of-the-ross-sea-antarctica-indications-for-long-term-downward-trends
#20
Karla Pozo, Tania Martellini, Simonetta Corsolini, Tom Harner, Victor Estellano, Petr Kukučka, Marie D Mulder, Gerhard Lammel, Alessandra Cincinelli
Passive air samplers were used to evaluate long-term trends and spatial distribution of trace organic compounds in Antarctica. Duplicate PUF disk samplers were deployed at six automatic weather stations in the coastal area of the Ross sea (East Antarctica), between December 2010 and January 2011, during the XXVI Italian Scientific Research Expedition. Among the investigated persistent organic compounds, Hexachlorobenzene was the most abundant, with air concentrations ranging from 0.8 to 50 pg m(-3). In general, the following decreasing concentration order was found for the air samples analyzed: HCB > PeCB > PCBs > DDTs > HCHs...
February 27, 2017: Chemosphere
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