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https://www.readbyqxmd.com/read/28209747/pediatric-adolescent-and-young-adult-thyroid-carcinoma-harbors-frequent-and-diverse-targetable-genomic-alterations-including-kinase-fusions
#1
Pierre Vanden Borre, Alexa B Schrock, Peter M Anderson, John C Morris, Andreas M Heilmann, Oliver Holmes, Kai Wang, Adrienne Johnson, Steven G Waguespack, Sai-Hong Ignatius Ou, Saad Khan, Kar-Ming Fung, Philip J Stephens, Rachel L Erlich, Vincent A Miller, Jeffrey S Ross, Siraj M Ali
BACKGROUND: Thyroid carcinoma, which is rare in pediatric patients (age 0-18 years) but more common in adolescent and young adult (AYA) patients (age 15-39 years), carries the potential for morbidity and mortality. METHODS: Hybrid-capture-based comprehensive genomic profiling (CGP) was performed prospectively on 512 consecutively submitted thyroid carcinomas, including 58 from pediatric and AYA (PAYA) patients, to identify genomic alterations (GAs), including base substitutions, insertions/deletions, copy number alterations, and rearrangements...
February 16, 2017: Oncologist
https://www.readbyqxmd.com/read/28178123/spectrum-of-pediatric-tumors-diagnosed-by-fine-needle-aspiration-cytology
#2
Sadegh Shirian, Yahya Daneshbod, Sezaneh Haghpanah, Bijan Khademi, Farshid Noorbakhsh, Amir Ghaemi, Ziba Mosayebi
Pediatric tumors differ markedly from adult tumors in their nature, distribution, and prognosis. In this 10-year retrospective study, we present our experience with fine-needle aspiration (FNA) in pediatric patients 18 years of age and younger and correlate relationship between gender with organ, diagnosis, malignancy, and age. In our study, FNA material of pediatric tumors or masses with 18 years aged and younger were analyzed retrospectively.All FNAs in pediatric patients during this time period were identified and analyzed for age, gender, cytologic diagnosis, and site of aspiration...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28176151/frequent-braf-v600e-and-absence-of-tert-promoter-mutations-characterize-sporadic-pediatric-papillary-thyroid-carcinomas-in-japan
#3
Naoki Oishi, Tetsuo Kondo, Tadao Nakazawa, Kunio Mochizuki, Tomohiro Inoue, Kazunari Kasai, Ippei Tahara, Tomonori Yabuta, Mitsuyoshi Hirokawa, Akira Miyauchi, Ryohei Katoh
Pediatric papillary thyroid carcinoma (PTC) has unique features but requires further genetic investigation. Moreover, there has been increasing concern about the risk for pediatric PTC in Japan after the Fukushima accident. This study aims to evaluate the frequencies of BRAF and TERT promoter mutations and to examine their significance in non-radiation-associated pediatric PTCs in Japan. We enrolled 81 pediatric PTC patients aged ≤20 years. The control group included 91 adult PTCs from patients >20 years old...
February 7, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28174375/-characteristics-of-adolescent-and-young-adult-cancer
#4
Keizo Horibe
In adolescent and young adult(AYA)population, cancer is the leading cause of death due to illness with the lowest mortality rate as well as children, and national measures for cancer was left behind. Leukemia, lymphomas, brain tumors, thyroid cancer, ovarian cancer, cervical cancer, breast cancer, testicular cancer and bone and soft tissue sarcomas account for majority of the cancers in this age group. There has been no significant improvement in AYA patients in contrast to other age groups. AYA patients with cancer are under growing independency, starting in life to the community, and reproductive age...
January 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28144251/permanent-and-transient-congenital-hypothyroidism-in-hamadan-west-province-of-iran
#5
Zahra Razavi, Lida Mohammadi
BACKGROUND: Primary congenital hypothyroidism (CH) is the most common treatable cause of mental retardation and can be classified into permanent and transient types. The purpose of this study was to determine the prevalence of permanent and transient congenital hypothyroidism (CH) in Hamadan, West province of Iran. METHODS: The study population included all cases with primary congenital hypothyroidism, which were confirmed by thyroid function tests (TSH levels ≥ 10 mIU/L)...
October 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28141710/the-curse-of-the-dolphins-cognitive-decline-and-psychosis
#6
Randall Phelps, Anne Tsai, Arlene Hagen, Joseph Pinter, Raegan Smith, Martin T Stein
Isela is an 11-year-old Mexican-American girl with mild intellectual disability. During a vacation with her family, she went swimming with dolphins. A few days later, Isela awoke at night with laughing spells; during the day, she was pacing, aggressive, and had a decline in self-care and communication skills. Her parents attributed the symptoms to the dolphins. She was evaluated by a pediatric neurologist. The sleep-deprived electroencephalogram, brain magnetic resonance imaging, lumbar puncture, and thyroid function tests were normal...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28135877/disparities-in-health-supervision-for-children-with-down-syndrome
#7
Katie Williams, David Wargowski, Jens Eickhoff, Ellen Wald
Increasing evidence suggests children with Down syndrome do not receive recommended health care services. We retrospectively assessed adherence to the 2001 American Academy of Pediatrics health supervision guidelines for 124 children with Down syndrome. Cervical spine radiographs were completed for 94% of children, often preoperatively. Adherence to complete blood count recommendations was 55% (95% CI 44% to 66%); lower for males ( P = .01) and children with private medical insurance ( P = .04). Adherence to thyroid function recommendations was 61% (95% CI 54% to 67%); higher for children seen by a pediatrician ( P = ...
January 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28127634/ultrasound-risk-stratification-for-malignancy-using-the-2015-american-thyroid-association-management-guidelines-for-children-with-thyroid-nodules-and-differentiated-thyroid-cancer
#8
Jennifer E Lim-Dunham, Iclal Erdem Toslak, Khalid Alsabban, Amany Aziz, Brendan Martin, Gokcan Okur, Katherine C Longo
BACKGROUND: The 2015 American Thyroid Association (ATA) Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer provides selection criteria for nodules prior to ultrasound-guided fine-needle aspiration biopsy. OBJECTIVE: To evaluate the diagnostic performance of pediatric thyroid nodule risk stratification for predicting malignancy when applying the ultrasound (US) criteria recommended. MATERIALS AND METHODS: US characteristics of 39 thyroid nodules in 33 pediatric patients who underwent US fine-needle aspiration biopsy were reviewed by two radiologists...
January 27, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28125451/clinical-and-morphologic-features-of-etv6-ntrk3-translocated-papillary-thyroid-carcinoma-in-an-adult-population-without-radiation-exposure
#9
Raja R Seethala, Simion I Chiosea, Cheng Z Liu, Marina Nikiforova, Yuri E Nikiforov
The ETV6-NTRK3 translocation characterizes a subset of radiation associated and pediatric papillary thyroid carcinomas (PTCs). We now describe the clinicopathologic features of ETV6-NTRK3 translocated PTC in an adult population without radiation exposure. Twelve cases were identified by next-generation sequencing (ThyroSeq version 2). The mean patient age was 37 years with a female predilection (10:2). Preoperative fine needle aspiration was performed on 6 patients of which 4 were classified as "malignant," whereas 2 were classified as "follicular lesion of undetermined significance...
January 25, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28124260/thyroid-hormone-intoxication-as-a-not-yet-described-cause-of-j-wave-syndrome-in-a-pediatric-patient
#10
J Carlos Flores-González, Branislava Grujic, Alfonso M Lechuga-Sancho
No abstract text is available yet for this article.
January 25, 2017: Endocrine
https://www.readbyqxmd.com/read/28109483/otorhinolaryngology-head-and-neck-surgery-in-a-low-income-country-the-haitian-experience
#11
Maxwell P Kligerman, Anahuma Alexandre, Patrick Jean-Gilles, David Walmer, Mack L Cheney, Anna H Messner
OBJECTIVE: Little is known regarding the diagnosis and management of pediatric surgical conditions of the head and neck in low-income countries. Haiti, the western hemisphere's poorest country, recently developed its first Otorhinolaryngology (ORL) department at the Hopital de L'Universite d'Etat d'Haiti (HUEH). This manuscript assesses the caseload at HUEH with a special emphasis on pediatric cases, with the aim of characterizing ORL related conditions and their treatments in low-income countries...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28098666/estimated-internal-and-external-radiation-exposure-of-caregivers-of-patients-with-pediatric-neuroblastoma-undergoing-131i-metaiodobenzylguanidine-therapy-a-prospective-pilot-study
#12
Sangwon Han, Seon Hee Yoo, Kyung-Nam Koh, Jong Jin Lee
PURPOSE: Current recommendations suggest that family members should participate in the care of children receiving in-hospital I metaiodobenzylguanidine (MIBG) therapy for neuroblastoma. The present study aimed to measure the external radiation exposure and estimate the internal radiation exposure of caregivers during the hospital stay for I MIBG therapy. MATERIALS AND METHODS: Caregivers received radiation safety instructions and a potassium iodide solution for thyroid blockade before patient admission...
January 16, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28096684/pediatric-papillary-thyroid-cancer-current-management-challenges
#13
REVIEW
Frederik A Verburg, Hanneke M Van Santen, Markus Luster
Although with a standardized incidence of 0.54 cases per 100,000 persons, differentiated thyroid cancer (DTC) is a rare disease in children and adolescents, it nonetheless concerns ~1.4% of all pediatric malignancies. Furthermore, its incidence is rising. Due to the rarity and long survival of pediatric DTC patients, in most areas of treatment little evidence exists. Treatment of pediatric DTC is therefore littered with controversies, many questions therefore remain open regarding the optimal management of pediatric papillary thyroid cancer (PTC), and many challenges remain unsolved...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28092393/surgical-treatment-of-adult-onset-esotropia-characteristics-and-outcomes
#14
Sara F Grace, Kara M Cavuoto, Wei Shi, Hilda Capo
PURPOSE: To describe the characteristics of the strabismus, surgical management, and outcomes of patients who underwent surgery for adult-onset esotropia. METHODS: This was a retrospective case study of patients at an academic tertiary referral center who underwent surgical treatment of esotropia acquired at or after age 18 years. Primary outcome measures were resolution of diplopia in primary position and a deviation of 10 prism diopters or less in primary gaze...
January 13, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28073489/cost-comparison-of-initial-lobectomy-versus-fine-needle-aspiration-for-diagnostic-workup-of-thyroid-nodules-in-children
#15
Katherine J Baxter, Heather L Short, Mitali A Thakore, Jeremy G Fisher, David H Rothstein, Kurt F Heiss, Mehul V Raval
BACKGROUND: Though uncommon in children, pediatric thyroid nodules carry a higher risk of malignancy than adult nodules. While fine-needle aspiration (FNA) has been well established as the initial diagnostic test in adults, it has been more slowly adopted in children. The purpose of this study was to examine the comparative cost of FNA versus initial diagnostic lobectomy (DL) in the pediatric patient with an ultrasound-confirmed thyroid nodule. METHODS: A decision tree model was created using an adolescent with an asymptomatic thyroid nodule as the reference case...
December 30, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28054375/effects-of-age-of-onset-on-disease-characteristics-in-non-segmental-vitiligo
#16
Berna Solak, Bahar Sevimli Dikicier, Nur C Cosansu, Teoman Erdem
In patients with vitiligo, the clinical and laboratory features of the disease may vary according to time of onset. This is addressed in the literature by only a few studies with conflicting results. The aim of this study was to determine the demographic and clinical features of patients with non-segmental vitiligo and to establish the association between vitiligo and autoimmune diseases with a focus on time of disease onset. A total of 224 vitiligo patients for whom complete medical records were available were evaluated retrospectively...
March 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28047358/su-f-t-117-a-pilot-study-of-organ-dose-reconstruction-for-wilms-tumor-patients-treated-with-radiation-therapy
#17
R Makkia, M Gopalakrishnan, C Lee, M Mille, C Pelletier, J Kalapurakal, C Lee, J Jung
PURPOSE: To reconstruct major organ doses for the Wilms tumor pediatric patients treated with radiation therapy using pediatric computational phantoms, treatment planning system (TPS), and Monte Carlo (MC) dose calculation methods. METHODS: A total of ten female and male pediatric patients (15-88 months old) were selected from the National Wilms Tumor Study cohort and ten pediatric computational phantoms corresponding to the patient's height and weight were selected for the organ dose reconstruction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28028338/cytological-diagnosis-of-pediatric-thyroid-nodule-in-perspective-of-the-bethesda-system-for-reporting-thyroid-cytopathology
#18
Chayanika Pantola, Sanjay Kala, Lubna Khan, Saurabh Pantola, Mahendra Singh, Sumanlata Verma
BACKGROUND: Thyroid nodule is one of the most common endocrinopathies occurring children and adolescents. Though thyroid nodule is rare in the pediatric age group, the rate of malignancy is much higher in this age group compared to adult population. AIM: The objective is to study the application of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric patients and compare the findings with histology. MATERIALS AND METHODS: A total of 218 cases younger than 18 years were studied in a 4-year period from August 2010 to July 2014...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28001468/long-term-quality-of-life-in-adult-survivors-of-pediatric-differentiated-thyroid-carcinoma
#19
Marloes Nies, Mariëlle S Klein Hesselink, Gea A Huizinga, Esther Sulkers, Adrienne H Brouwers, Johannes G M Burgerhof, Eveline W C M van Dam, Bas Havekes, Marry M van den Heuvel-Eibrink, Eleonora P M Corssmit, Leontien C M Kremer, Romana T Netea-Maier, Heleen J H van der Pal, Robin P Peeters, John T M Plukker, Cécile M Ronckers, Hanneke M van Santen, Wim J E Tissing, Thera P Links, Gianni Bocca
INTRODUCTION: Little is known about long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma (DTC). Therefore, this study aimed to evaluate generic health-related QoL (HRQoL), fatigue, anxiety, and depression in adult survivors of pediatric DTC compared with matched controls, and to evaluate thyroid cancer-specific HRQoL in survivors only. MATERIALS AND METHODS: Adult survivors of pediatric DTC, diagnosed between 1970-2013 at age <18 years were included...
December 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27990597/ultrasound-guided-core-needle-biopsy-in-the-diagnosis-of-neuroblastic-tumors-in-children-a-retrospective-study-on-83-cases
#20
Lihui Zhao, Jie Mu, Ping Du, Hailing Wang, Yiran Mao, Yong Xu, Xiaojie Xin, Fenglin Zang
AIM: Ultrasound-guided biopsy technique with the large-core needle has widely been applied in the diagnosis of adult abdominopelvic cavity, thyroid, and neck tumors. There are few reports on ultrasound-guided biopsy using large-core needle in pediatric abdominopelvic cavity tumors. This study was to evaluate the ultrasound features and the diagnostic value of ultrasound-guided core needle biopsy for pediatric neuroblastic tumors. METHODS: The pediatric patients with neuroblastic tumor that underwent ultrasound examination and ultrasound-guided core needle biopsy from January 2009 to November 2015 were reviewed...
December 18, 2016: Pediatric Surgery International
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