Ting Xu, Xiaogang Ning, Jiayan Wu, Qian Wang, Zhifei Wang, Zhiqing Chen, Xiaoxian Tang, Peirong Bai, Kanyi Pu, Liping Li, Ruiping Zhang
Inflammatory bowel disease (IBD) is strongly related to the occurrence of accumulation of toxic reactive oxygen species (ROS), inflammation of the mucosa, and an imbalance of intestinal microbes. However, current treatments largely focus on a single factor, yielding unsatisfactory clinical outcomes. Herein, we report a biocompatible and IBD-targeted metabolic nanoregulator (TMNR) that synergistically regulates cellular and bacterial metabolism. The TMNR comprises a melanin-gallium complex (MNR) encapsulated within a thermosensitive and colitis-targeting hydrogel, all composed of natural and FDA-approved components...
February 23, 2024: ACS Nano