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Nari Ahn, Yea Hyun Leem, Morimasa Kato, Hyukki Chang
PURPOSE: The effects of creatine and exercise on chronic stress-induced depression are unclear. In the present study, we identified the effects of 4-week supplementation of creatine monohydrate and/or exercise on antidepressant behavior and raphe 5-HT expression in a chronic mild stress-induced depressed mouse model. METHODS: Seven-week-old male C57BL/6 mice (n=48) were divided randomly into 5 groups: (1) non-stress control (CON, n=10), (2) stress control (ST-CON, n=10), (3) stress and creatine intake (ST-Cr, n=10), (4) stress and exercise (ST-Ex, n=9), and (5) combined stress, exercise, and creatine intake (ST-Cr+Ex, n=9)...
September 2016: Journal of Exercise Nutrition & Biochemistry
Wei Zou, Ao Shen, Xintong Dong, Madina Tugizova, Yang K Xiang, Kang Shen
Ligand receptor interactions instruct axon guidance during development. How dendrites are guided to specific targets is less understood. The C. elegans PVD sensory neuron innervates muscle-skin interface with its elaborate dendritic branches. Here, we found that LECT-2, the ortholog of leukocyte cell-derived chemotaxin-2 (LECT2), is secreted from the muscles and required for muscle innervation by PVD. Mosaic analyses showed that LECT-2 acted locally to guide the growth of terminal branches. Ectopic expression of LECT-2 from seam cells is sufficient to redirect the PVD dendrites onto seam cells...
October 5, 2016: ELife
John M Findlay, Kevin M Bradley, Lai Mun Wang, Jamies M Franklin, Eugene J Teoh, Fergus V Gleeson, Nicholas D Maynard, Richard S Gillies, Mark R Middleton
INTRODUCTION: Only a minority of esophageal cancers demonstrates a pathological tumor response (pTR) to neoadjuvant chemotherapy (NAC). (18)F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) is often used for restaging after NAC and to assess response. Increasingly, it is used during therapy to identify unresponsive tumors and predict pTR , using avidity of the primary tumor alone. However, definitions of such metabolic tumor response (mTR) vary. We aimed to comprehensively re-evaluate metabolic response assessment using accepted parameters, as well as novel concepts of metabolic nodal stage (mN) and nodal response (mNR)...
September 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Priyadarshini Pantham, Fredrick J Rosario, Susan T Weintraub, Peter W Nathanielsz, Theresa L Powell, Cun Li, Thomas Jansson
Intrauterine growth restriction (IUGR) is an important risk factor for perinatal complications and adult disease. IUGR is associated with down-regulation of placental amino acid (AA) transporter expression and activity at birth. It is unknown whether these changes are a cause or a consequence of human IUGR. We hypothesized that placental AA transport capacity is reduced prior to onset of reduced fetal growth in baboons with maternal nutrient restriction (MNR). Pregnant baboons were fed either a control (n=8) or MNR diet (70% of control diet, n=9) from Gestational Day (GD) 30...
September 7, 2016: Biology of Reproduction
Carlos A Díaz-Balzac, Maisha Rahman, María I Lázaro-Peña, Lourdes A Martin Hernandez, Yehuda Salzberg, Cristina Aguirre-Chen, Zaven Kaprielian, Hannes E Bülow
Sensory dendrite arbors are patterned through cell-autonomously and non-cell-autonomously functioning factors [1-3]. Yet, only a few non-cell-autonomously acting proteins have been identified, including semaphorins [4, 5], brain-derived neurotrophic factors (BDNFs) [6], UNC-6/Netrin [7], and the conserved MNR-1/Menorin-SAX-7/L1CAM cell adhesion complex [8, 9]. This complex acts from the skin to pattern the stereotypic dendritic arbors of PVD and FLP somatosensory neurons in Caenorhabditis elegans through the leucine-rich transmembrane receptor DMA-1/LRR-TM expressed on PVD neurons [8, 9]...
September 12, 2016: Current Biology: CB
Taisy Cinthia Ferro Cavalcante, Amanda Alves Marcelino da Silva, Larissa Cavalcanti do Amaral Almeida, Gabriel Araújo Tavares, Renata Cristinny de Farias Campina, Elizabeth do Nascimento, Sandra Lopes de Souza
In neonatal rats, hunger and satiety responses occur particularly via dehydration and gastric distention, respectively. The control of food intake in newborns is yet to be fully consolidated, particularly with respect to the participation of the hypothalamic nuclei and their relationship with the serotonergic pathway. Moreover, it is unclear how the environmental stressors in early life, like undernutrition, interfere in these events. Therefore, this study examined the serotonin-system's impact on food intake in rat neonates at postnatal day (P) 10 and P18 and the manner in which protein undernutrition during pregnancy and lactation interferes in this behavior...
October 15, 2016: Physiology & Behavior
Elena Solana-Madruga, Ángel M Arévalo-López, Antonio J Dos Santos-García, Esteban Urones-Garrote, David Ávila-Brande, Regino Sáez-Puche, J Paul Attfield
Cation ordering in ABO3 perovskites adds to their chemical variety and can lead to properties such as ferrimagnetism and magnetoresistance in Sr2 FeMoO6 . Through high-pressure and high-temperature synthesis, a new type of "double double perovskite" structure has been discovered in the family MnRMnSbO6 (R=La, Pr, Nd, Sm). This tetragonal structure has a 1:1 order of cations on both A and B sites, with A-site Mn(2+) and R(3+) cations ordered in columns and Mn(2+) and Sb(5+) having rock salt order on the B sites...
August 1, 2016: Angewandte Chemie
Nathalia P Cavaleiro, Antonio M Solé-Cava, Cláudio M R Melo, Luiz G de Almeida, Cristiano Lazoski, Ana Tereza R Vasconcelos
The complete mitochondrial genome of Crassostrea gasar was sequenced using the Ion Proton technology in combination with 454 Roche GS-FLX plataform data. We assembled a 17,686 bp complete circular mitochondrial genome, containing 13 protein-coding genes, a major non-coding region (MNR), two ribosomal RNA genes and 24 transfer RNA genes. Phylogenetic analysis of concatenated amino acid sequences from mitochondria showed monophyletic clades formed with high bootstrap values. This is the first complete mitochondrial sequence of an oyster from South America...
July 2016: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
Tanapon Phenrat, Ashijya Otwong, Aphichart Chantharit, Gregory V Lowry
BACKGROUND: Klity Creek has become Thailand's first official remediation ordered by the court in 2013, 15 years after the spill of lead (Pb) contaminated mine tailing into the creek. The Pollution Control Department (PCD) decided to restore the creek through monitored natural recovery (MNR) since 2006 but has not been successful. Interestingly, the most recent remediation plan in 2015 will still apply MNR to five out of the seven portions of the creek, despite no scientific feasibility evaluation of using MNR to restore the creek...
May 8, 2016: Environmental Health Perspectives
C Hellmuth, O Uhl, F F Kirchberg, U Harder, W Peissner, B Koletzko, P W Nathanielsz
BACKGROUND AND AIMS: Moderately reduced maternal nutrient availability during pregnancy has adverse effects on the fetuses' growth and metabolism during and after pregnancy. The aim of this study was to explore effects of maternal nutrition restriction (MNR) on key metabolites of the fetal energy metabolism, particularly amino acids (AA), nonesterified fatty acids (NEFA), acylcarnitines and phospholipids. These effects may reflect mechanisms relating MNR to later adverse outcomes. METHODS AND RESULTS: Plasma and liver samples of fetal baboons, whose mothers were fed ad libitum (CTR) or MNR (70% of CTR), were collected at 0...
September 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A M Swanson, V Mehta, K Ofir, M Rowe, C Rossi, Y Ginsberg, H Griffin, H Barker, T White, M Boyd, A L David
Fetal growth restriction (FGR) is a common and potentially severe pregnancy complication. Currently there is no treatment available. The guinea pig is an attractive model of human pregnancy as placentation is morphologically very similar between the species. Nutrient restriction of the dam creates growth-restricted fetuses while leaving an intact uteroplacental circulation, vital for evaluating novel therapies for FGR. Growth-restricted fetuses were generated by feeding Dunkin Hartley guinea pig dams 70% of ad libitum intake from four weeks before and throughout pregnancy...
April 26, 2016: Laboratory Animals
Yuko Mabuchi, Theresa L Frankel
Racing pigeons are exposed to and act as carriers of diseases. Dietary protein requirement for their maintenance has not been determined experimentally despite their being domesticated for over 7000 years. A maintenance nitrogen (protein) requirement (MNR) for pigeons was determined in a balance study using diets containing 6, 10 and 14% crude protein (CP). Then, the effects of feeding the diets were investigated to determine whether they were adequate to sustain innate and acquired immune functions. Nitrogen intake from the 6% CP diet was sufficient to maintain nitrogen balance and body weight in pigeons...
March 2016: Royal Society Open Science
Santosh M Patil, Avinash Gurujala, Ashok Kumar, Kuthadi Sravan Kumar, Gorre Mithun
INTRODUCTION: Lichtenstein's tension free mesh hernioplasty is the commonly done open technique for inguinal hernias. As our hospital is in rural area, majority of patients are labourers, open hernias are commonly done. The present study was done by comparing Lichtenstein Mesh Repair (LMR) v/s Modified Bassini's repair (MBR) + Lichtenstein mesh repair (LMR) of direct Inguinal Hernias to compare the technique of both surgeries and its outcome like postoperative complications and recurrence rate...
February 2016: Journal of Clinical and Diagnostic Research: JCDR
Kwang Yeol Paik, Eung Kook Kim
BACKGROUND: Pathologic response (PR) predicts survival after preoperative chemotherapy and resection of a malignancy. Occasionally, transarterial chemoembolization (TACE) may be selected for preoperative management of resectable hepatocellular carcinoma (HCC). This study investigated whether PR to preoperative TACE can predict recurrence after resection for resectable HCC. METHODS: We conducted analysis of 106 HCC patients who underwent TACE followed by liver resection with a curative intent...
April 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Valéria L G Panissa, Cesar C Cal Abad, Ursula F Julio, Leonardo V Andreato, Emerson Franchini
UNLABELLED: Prupose: To investigate the effects of a 5-km high-intensity interval exercise (HIIE) on heart rate variability (HRV) and subsequent strength performance. METHODS: Nine trained males performed a control session composed of a half-squat strength exercise (4 × 80% of one repetition maximum-1 RM) in isolation and 30-min, 1-, 4-, 8-, and 24-h after an HIIE (1-min at the velocity peak:1-min passive recovery). All experimental sessions were performed on different days...
2016: Frontiers in Physiology
John M Findlay, Richard S Gillies, James M Franklin, Eugene J Teoh, Greg E Jones, Sara di Carlo, Fergus V Gleeson, Nicholas D Maynard, Kevin M Bradley, Mark R Middleton
OBJECTIVES: It is unknown whether restaging oesophageal cancer after neoadjuvant therapy with positron emission tomography-computed tomography (PET-CT) is more sensitive than contrast-enhanced CT for disease progression. We aimed to determine this and stratify risk. METHODS: This was a retrospective study of patients staged before neoadjuvant chemotherapy (NAC) by (18)F-FDG PET-CT and restaged with CT or PET-CT in a single centre (2006-2014). RESULTS: Three hundred and eighty-three patients were restaged (103 CT, 280 PET-CT)...
October 2016: European Radiology
N Mehta, A Kumar
Calorimetric study of glass/crystal phase transformation in disordered semiconductors is a significant tool for understanding their crystallization kinetics. Such studies provide the basis for practical application of glasses. Differential scanning calorimetry (DSC) is one of the advanced techniques for the analysis of thermally induced crystallization in glassy or amorphous systems. We are reporting the nonisothermal DSC measurements on four amorphous systems of Se70Te30 alloy with Ag, Cd, Sb, and Zn as chemical modifiers...
February 18, 2016: Journal of Physical Chemistry. B
Andrew Ghaly, Alex Xu, Karen Nygard, Brad Matushewski, Robert Hammond, Bryan S Richardson, A Elias
No abstract text is available yet for this article.
December 2015: International Journal of Developmental Neuroscience
Wen-Xing Yang
We investigate the high-order harmonic generation (HHG) in a semiconductor quantum dot (SQD) and metallic nanorod (MNR) complex driven by a moderate intensity (<10(12)  W/cm(2)) frequency-chirped Gaussian few-cycle pulse. Our numerical results indicate that the cutoff energy of the HHG can be controlled by optimizing the shape of the MNR and surface-to-surface distance between the SQD and the MNR. We also show that the extreme ultraviolet supercontinuum harmonics (25 eV maximal photon energy) and isolated ultrashort pulses (2...
November 1, 2015: Optics Letters
K A Ravi Varma Prasad, Sajil John, V Deepika, K S Dwijendra, Babu Ram Reddy, Siddharth Chincholi
BACKGROUND: Mouthwashes are an adjunct to, not a substitute for, regular brushing and flossing. Chlorohexidine is cationic bis-biguanide broad spectrum antiseptic with both anti-plaque and antibacterial properties. It has side-effects like brownish discoloration of teeth and dorsum of the tongue, taste perturbation, oral mucosal ulceration, etc. To compare the antiplaque efficacy of herbal and chlorohexidine gluconate mouthwash. MATERIALS AND METHODS: A double-blinded parallel, randomized controlled clinical trial was conducted in the Department of Periodontics, MNR Dental College...
August 2015: Journal of International Oral Health: JIOH
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