keyword
MENU ▼
Read by QxMD icon Read
search

sensitive detection

keyword
https://www.readbyqxmd.com/read/28231691/evaluation-of-diagnostic-performance-of-screening-thyroid-ultrasonography-us-and-imaging-findings-of-screening-detected-thyroid-cancer
#1
Jeongin Yoo, Hye Shin Ahn, Soo Jin Kim, Sung Hee Park, Mirinae Seo, Semin Chong
Purpose: To evaluate the diagnostic performance and cost of screening thyroid ultrasonography (US) in an asymptomatic population and determine the US features of screening-detected thyroid cancer. Materials and Methods: This study included 1845 asymptomatic participants who underwent screening thyroid US between March and August 2012 at the screening center in our hospital. We evaluated the diagnostic performance of screening thyroid US for thyroid cancer and the average cost of diagnosis for each patient...
February 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28231553/a-reusable-aptasensor-of-thrombin-based-on-dna-machine-employing-resonance-light-scattering-technique
#2
Yining Hou, Jifeng Liu, Min Hong, Xia Li, Yanhua Ma, Qiaoli Yue, Chen-Zhong Li
The design of molecular nanodevices attracted great interest in these years. Herein, a reusable, sensitive and specific aptasensor was constructed based on an extension-contraction movement of DNA interconversion for the application of human thrombin detection. The present biosensor was based on resonance light scattering (RLS) using magnetic nanoparticles (MNPs) as the RLS probe. MNPs coated with streptavidin can combine with biotin labeled thrombin aptamers. The combined nanoparticles composite is monodispersed in aqueous medium...
February 20, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28231529/new-enantioselective-lc-method-development-and-validation-for-the-assay-of-modafinil
#3
Marianna Harvanová, Taťána Gondová
For the first time, a new, fast and sensitive chromatographic method for the separation and determination of modafinil enantiomers was developed on chiral stationary phase with macrocyclic glycopeptide teicoplanin in the polar organic mode. The effect of the mobile phase composition and column temperature on the retention and enantioseparation were studied. The separation was performed using a Chirobiotic T column (250×4.6mm, 5μm) with methanol and triethylamine (100/0.05, v/v) as the mobile phase at a flow rate of 1...
February 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28231525/construction-of-new-est-ssrs-for-fusarium-resistant-wheat-breeding
#4
Aysen Yumurtaci, Hulya Sipahi, Ayed Al-Abdallat, Abdulqader Jighly, Michael Baum
Surveying Fusarium resistance in wheat with easy applicable molecular markers such as simple sequence repeats (SSRs) is a prerequest for molecular breeding. Expressed sequence tags (ESTs) are one of the main sources for development of new SSR candidates. Therefore, 18.292 publicly available wheat ESTs were mined and genotyping of newly developed 55 EST-SSR derived primer pairs produced clear fragments in ten wheat cultivars carrying different levels of Fusarium resistance. Among the proved markers, 23 polymorphic EST-SSRs were obtained and related alleles were mostly found on B and D genome...
February 11, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28231511/automated-diagnosis-of-congestive-heart-failure-using-dual-tree-complex-wavelet-transform-and-statistical-features-extracted-from-2s-of-ecg-signals
#5
Vidya K Sudarshan, U Rajendra Acharya, Shu Lih Oh, Muhammad Adam, Jen Hong Tan, Chua Kuang Chua, Kok Poo Chua, Ru San Tan
Identification of alarming features in the electrocardiogram (ECG) signal is extremely significant for the prediction of congestive heart failure (CHF). ECG signal analysis carried out using computer-aided techniques can speed up the diagnosis process and aid in the proper management of CHF patients. Therefore, in this work, dual tree complex wavelets transform (DTCWT)-based methodology is proposed for an automated identification of ECG signals exhibiting CHF from normal. In the experiment, we have performed a DTCWT on ECG segments of 2s duration up to six levels to obtain the coefficients...
February 7, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28231386/evaluating-the-effectiveness-of-rna-in-situ-hybridization-for-detecting-lung-adenocarcinoma-with-anaplastic-lymphoma-kinase-rearrangement
#6
Naoki Nakajima, Akihiko Yoshizawa, Kyoko Kondo, Mariyo Rokutan-Kurata, Masahiro Hirata, Ayako Furuhata, Shinji Sumiyoshi, Makoto Sonobe, Toshi Menju, Masanobu Momose, Masakazu Fujimoto, Hiroshi Date, Hironori Haga
AIMS: An easy and rapid assay for detecting mRNA in formalin-fixed paraffin-embedded samples (RNA-in situ hybridization; RNA-ISH) has been reported recently. We investigated the diagnostic accuracy of RNA-ISH for detecting lung adenocarcinoma (LA) with anaplastic lymphoma kinase (ALK) gene rearrangement. METHODS AND RESULTS: We tested ALK RNA-ISH on 11 resected LAs for which ALK fusion was confirmed by immunohistochemistry (IHC) and/or fluorescence in situ hybridization (FISH)...
February 23, 2017: Histopathology
https://www.readbyqxmd.com/read/28231300/detection-and-partial-discrimination-of-atypical-and-classical-bovine-spongiform-encephalopathies-in-cattle-and-primates-using-real-time-quaking-induced-conversion-assay
#7
Etienne Levavasseur, Anne-Gaëlle Biacabe, Emmanuel Comoy, Audrey Culeux, Katarina Grznarova, Nicolas Privat, Steve Simoneau, Benoit Flan, Véronique Sazdovitch, Danielle Seilhean, Thierry Baron, Stéphane Haïk
The transmission of classical bovine spongiform encephalopathy (C-BSE) through contaminated meat product consumption is responsible for variant Creutzfeldt-Jakob disease (vCJD) in humans. More recent and atypical forms of BSE (L-BSE and H-BSE) have been identified in cattle since the C-BSE epidemic. Their low incidence and advanced age of onset are compatible with a sporadic origin, as are most cases of Creutzfeldt-Jakob disease (CJD) in humans. Transmissions studies in primates and transgenic mice expressing a human prion protein (PrP) indicated that atypical forms of BSE may be associated with a higher zoonotic potential than classical BSE, and require particular attention for public health...
2017: PloS One
https://www.readbyqxmd.com/read/28231244/unexpectedly-high-leprosy-seroprevalence-detected-using-a-random-surveillance-strategy-in-midwestern-brazil-a-comparison-of-elisa-and-a-rapid-diagnostic-test
#8
Marco Andrey C Frade, Natália A de Paula, Ciro M Gomes, Sebastian Vernal, Fred Bernardes Filho, Helena B Lugão, Marilda M M de Abreu, Patrícia Botini, Malcolm S Duthie, John S Spencer, Rosa Castália F R Soares, Norma T Foss
BACKGROUND: Leprosy diagnosis is mainly based on clinical evaluation, although this approach is difficult, especially for untrained physicians. We conducted a temporary campaign to detect previously unknown leprosy cases in midwestern Brazil and to compare the performance of different serological tests. METHODS: A mobile clinic was stationed at the main bus terminal in Brasília, Brazil. Volunteers were quizzed and given a clinical exam to allow categorization as either patients, known contacts of patients or non-contacts, and blood was collected to determine anti-PGL-I and anti-LID-1 antibody titers by ELISA and by the NDO-LID rapid test...
February 23, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28231242/predicting-ebola-infection-a-malaria-sensitive-triage-score-for-ebola-virus-disease
#9
Mary-Anne Hartley, Alyssa Young, Anh-Minh Tran, Harry Henry Okoni-Williams, Mohamed Suma, Brooke Mancuso, Ahmed Al-Dikhari, Mohamed Faouzi
BACKGROUND: The non-specific symptoms of Ebola Virus Disease (EVD) pose a major problem to triage and isolation efforts at Ebola Treatment Centres (ETCs). Under the current triage protocol, half the patients allocated to high-risk "probable" wards were EVD(-): a misclassification speculated to predispose nosocomial EVD infection. A better understanding of the statistical relevance of individual triage symptoms is essential in resource-poor settings where rapid, laboratory-confirmed diagnostics are often unavailable...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28231130/evaluation-of-turmeric-powder-adulterated-with-metanil-yellow-using-ft-raman-and-ft-ir-spectroscopy
#10
Sagar Dhakal, Kuanglin Chao, Walter Schmidt, Jianwei Qin, Moon Kim, Diane Chan
Turmeric powder (Curcuma longa L.) is valued both for its medicinal properties and for its popular culinary use, such as being a component in curry powder. Due to its high demand in international trade, turmeric powder has been subject to economically driven, hazardous chemical adulteration. This study utilized Fourier Transform-Raman (FT-Raman) and Fourier Transform-Infra Red (FT-IR) spectroscopy as separate but complementary methods for detecting metanil yellow adulteration of turmeric powder. Sample mixtures of turmeric powder and metanil yellow were prepared at concentrations of 30%, 25%, 20%, 15%, 10%, 5%, 1%, and 0...
May 17, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231034/upscaling-of-hips-cell-derived-neurons-for-high-throughput-screening
#11
Stefanie Traub, Heiko Stahl, Holger Rosenbrock, Eric Simon, Ralf Heilker
The advent of human-induced pluripotent stem (hiPS) cell-derived neurons promised to provide better model cells for drug discovery in the context of the central nervous system. This work demonstrates both the upscaling of cellular expansion and the acceleration of neuronal differentiation to accommodate the immense material needs of a high-throughput screening (HTS) approach. Using GRowth factor-driven expansion and INhibition of NotCH (GRINCH) during maturation, the derived cells are here referred to as GRINCH neurons...
March 2017: SLAS Discov
https://www.readbyqxmd.com/read/28231033/evaluation-of-a-commercial-field-test-to-detect-african-swine-fever
#12
Stefano Cappai, Federica Loi, Annamaria Coccollone, Manuele Cocco, Caterina Falconi, Giovanna Dettori, Francesco Feliziani, Maria Luisa Sanna, Annalisa Oggiano, Sandro Rolesu
African swine fever (ASF) is one of the most important and complex infectious diseases affecting pigs ( Sus scrofa ). The disease has been present in Sardinia, Italy, since 1978. Factors influencing the presence of the disease on the island are the presence of illegally bred pigs, uncontrolled movements of animals, and local traditions. Implementation of public health programs is essential for controlling ASF. The use of new diagnostic techniques on both wild boar (WB) and illegally bred pigs would provide tools for faster and more inexpensive control of the disease...
February 23, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28230832/specific-interactions-between-lectins-and-red-blood-cells-of-chornobyl-cleanup-workers-as-indicator-of-some-late-radiation-effects
#13
I S Karpova
AIM: Growing interest in lectins is based on their diagnostic and pharmacological potential, especially the ability to inhibit proliferation and initiate apoptosis of cancer cells. In our research microplate lectinoassay able to detect carbohydrate containing structures (receptors) on erythrocyte surface have been proposed for Chornobyl cleanup workers (1986) monitoring. It was expected to reveal specific abnormalities associated with pathological condition arising as a result of late radiation effects...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230821/circulating-hematopoietic-progenitor-cells-in-patients-affected-by-chornobyl-accident
#14
N M Bilko, I S Dyagil, I Z Russu, D I Bilko
: High radiation sensitivity of stem cells and their ability to accumulate sublethal radiation damage provides the basis for investigation of hematopoietic progenitors using in vivo culture methodology. Unique samples of peripheral blood and bone marrow were derived from the patients affected by Chornobyl accident during liquidation campaign. AIM: To investigate functional activity of circulating hematopoietic progenitor cells from peripheral blood and bone marrow of cleanup workers in early and remote periods after the accident at Chornobyl nuclear power plant (CNPP)...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230807/effect-of-reduction-of-redox-modifications-of-cys-residues-in-the-na-k-atpase-%C3%AE-1-subunit-on-its-activity
#15
Elena A Dergousova, Irina Yu Petrushanko, Elizaveta A Klimanova, Vladimir A Mitkevich, Rustam H Ziganshin, Olga D Lopina, Alexander A Makarov
Sodium-potassium adenosine triphosphatase (Na,K-ATPase) creates a gradient of sodium and potassium ions necessary for the viability of animal cells, and it is extremely sensitive to intracellular redox status. Earlier we found that regulatory glutathionylation determines Na,K-ATPase redox sensitivity but the role of basal glutathionylation and other redox modifications of cysteine residues is not clear. The purpose of this study was to detect oxidized, nitrosylated, or glutathionylated cysteine residues in Na,K-ATPase, evaluate the possibility of removing these modifications and assess their influence on the enzyme activity...
February 21, 2017: Biomolecules
https://www.readbyqxmd.com/read/28230757/simultaneous-quantification-of-nine-new-furanocoumarins-in-angelicae-dahuricae-radix-using-ultra-fast-liquid-chromatography-with-tandem-mass-spectrometry
#16
Lei Zhang, Wei Wei, Xiu-Wei Yang
A series of new furanocoumarins with long-chain hydrophobic groups, namely andafocoumarins A-H and J, have been isolated from the dried roots of Angelica dahurica cv. Hangbaizhi (Angelicae Dahuricae radix) in our previous study, among which andafocoumarins A and B were demonstrated to have better anti-inflammatory activity than the positive controls. In this work, a sensitive, accurate, and efficient ultra-fast liquid chromatography coupled with triple quadrupole mass spectrometer (UFLC-MS/MS) method was developed and validated for simultaneous quantification of above-mentioned nine compounds in four cultivars of Angelicae Dahuricae Radix...
February 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230717/imaging-performance-of-a-handheld-ultrasound-system-with-real-time-computer-aided-detection-of-lumbar-spine-anatomy-a-feasibility-study
#17
Mohamed Tiouririne, Adam J Dixon, F William Mauldin, David Scalzo, Arun Krishnaraj
OBJECTIVES: The aim of this study was to evaluate the imaging performance of a handheld ultrasound system and the accuracy of an automated lumbar spine computer-aided detection (CAD) algorithm in the spines of human subjects. MATERIALS AND METHODS: This study was approved by the institutional review board of the University of Virginia. The authors designed a handheld ultrasound system with enhanced bone image quality and fully automated CAD of lumbar spine anatomy...
February 22, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28230526/sensitivity-to-image-recurrence-across-eye-movement-like-image-transitions-through-local-serial-inhibition-in-the-retina
#18
Vidhyasankar Krishnamoorthy, Michael Weick, Tim Gollisch
Standard models of stimulus encoding in the retina postulate that image presentations activate neurons according to the increase of preferred contrast inside the receptive field. During natural vision, however, images do not arrive in isolation, but follow each other rapidly, separated by sudden gaze shifts. We here report that, contrary to standard models, specific ganglion cells in mouse retina are suppressed after a rapid image transition by changes in visual patterns across the transition, but respond with a distinct spike burst when the same pattern reappears...
February 23, 2017: ELife
https://www.readbyqxmd.com/read/28230465/hypnotic-tactile-anesthesia-psychophysical-and-signal-detection-analyses
#19
Douglas J Tataryn, John F Kihlstrom
Two experiments that studied the effects of hypnotic suggestions on tactile sensitivity are reported. Experiment 1 found that suggestions for anesthesia, as measured by both traditional psychophysical methods and signal-detection procedures, were linearly related to hypnotizability. Experiment 2 employed the same methodologies in an application of the real-simulator paradigm to examine the effects of suggestions for both anesthesia and hyperesthesia. Significant effects of hypnotic suggestion on both sensitivity and bias were found in the anesthesia condition but not for the hyperesthesia condition...
April 2017: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/28230396/detecting-target-changes-in-multiple-object-tracking-with-peripheral-vision-more-pronounced-eccentricity-effects-for-changes-in-form-than-in-motion
#20
Christian Vater, Ralf Kredel, Ernst-Joachim Hossner
In the current study, dual-task performance is examined with multiple-object tracking as a primary task and target-change detection as a secondary task. The to-be-detected target changes in conditions of either change type (form vs. motion; Experiment 1) or change salience (stop vs. slowdown; Experiment 2), with changes occurring at either near (5°-10°) or far (15°-20°) eccentricities (Experiments 1 and 2). The aim of the study was to test whether changes can be detected solely with peripheral vision. By controlling for saccades and computing gaze distances, we could show that participants used peripheral vision to monitor the targets and, additionally, to perceive changes at both near and far eccentricities...
February 23, 2017: Journal of Experimental Psychology. Human Perception and Performance
keyword
keyword
77181
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"