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https://www.readbyqxmd.com/read/28444138/the-evolution-of-neuropeptide-signalling-insights-from-echinoderms
#1
Dean C Semmens, Maurice R Elphick
Neuropeptides are evolutionarily ancient mediators of neuronal signalling that regulate a wide range of physiological processes and behaviours in animals. Neuropeptide signalling has been investigated extensively in vertebrates and protostomian invertebrates, which include the ecdysozoans Drosophila melanogaster (Phylum Arthropoda) and Caenorhabditis elegans (Phylum Nematoda). However, until recently, an understanding of evolutionary relationships between neuropeptide signalling systems in vertebrates and protostomes has been impaired by a lack of genome/transcriptome sequence data from non-ecdysozoan invertebrates...
April 21, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/28443608/dynamic-behaviour-of-interphases-and-its-implication-on-high-energy-density-cathode-materials-in-lithium-ion-batteries
#2
Wangda Li, Andrei Dolocan, Pilgun Oh, Hugo Celio, Suhyeon Park, Jaephil Cho, Arumugam Manthiram
Undesired electrode-electrolyte interactions prevent the use of many high-energy-density cathode materials in practical lithium-ion batteries. Efforts to address their limited service life have predominantly focused on the active electrode materials and electrolytes. Here an advanced three-dimensional chemical and imaging analysis on a model material, the nickel-rich layered lithium transition-metal oxide, reveals the dynamic behaviour of cathode interphases driven by conductive carbon additives (carbon black) in a common nonaqueous electrolyte...
April 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28442788/changes-in-structural-and-pigmentary-colours-in-response-to-cold-stress-in-polyommatus-icarus-butterflies
#3
Krisztián Kertész, Gábor Piszter, Zsolt Endre Horváth, Zsolt Bálint, László Péter Biró
While numerous papers have investigated the effects of thermal stress on the pigmentary colours of butterfly wings, such studies regarding structural colours are mostly lacking, despite the important role they play in sexual communication. To gain insight into the possible differences between the responses of the two kinds of colouration, we investigated the effects of prolonged cold stress (cooling at 5 °C for up to 62 days) on the pupae of Polyommatus icarus butterflies. The wing surfaces coloured by photonic crystal-type nanoarchitectures (dorsal) and by pigments (ventral) showed markedly different behaviours...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28441949/-it-s-so-hard-taking-pills-when-you-don-t-know-what-they-re-for-a-qualitative-study-of-patients-medicine-taking-behaviours-and-conceptualisation-of-medicines-in-the-context-of-rheumatoid-arthritis
#4
Boitshoko Kobue, Shirra Moch, Jennifer Watermeyer
BACKGROUND: Patients with chronic illnesses are often required to take lifelong medication to alleviate symptoms and prevent disease progression. Many patients find it difficult to adhere to prescribed medication for various reasons, some of which may link to the way they conceptualise medicines and understand their illness and treatment. This study explores the medicine taking behaviours of patients presenting with Rheumatoid Arthritis (RA), a chronic inflammatory autoimmune disease...
April 26, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28432495/investigating-emotional-contagion-in-dogs-canis-familiaris-to-emotional-sounds-of-humans-and-conspecifics
#5
Annika Huber, Anjuli L A Barber, Tamás Faragó, Corsin A Müller, Ludwig Huber
Emotional contagion, a basic component of empathy defined as emotional state-matching between individuals, has previously been shown in dogs even upon solely hearing negative emotional sounds of humans or conspecifics. The current investigation further sheds light on this phenomenon by directly contrasting emotional sounds of both species (humans and dogs) as well as opposed valences (positive and negative) to gain insights into intra- and interspecies empathy as well as differences between positively and negatively valenced sounds...
April 21, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28431345/insights-into-targeting-young-male-drivers-with-anti-speeding-advertising-an-application-of-the-step-approach-to-message-design-and-testing-satmdt
#6
I Lewis, K M White, B Ho, B Elliott, B Watson
In Australia, young drivers aged 17-25 years comprise 13% of the population yet account for 22% of all road deaths with young males over-represented in such trauma. Speeding represents a major contributing factor and advertising campaigns have long focused on promoting anti-speeding messages in the effort to reduce drivers' speeds. Positioned within a larger program of research aimed at developing, piloting, and evaluating a range of theoretically-informed anti-speeding messages, the current study reports results relating to the final phase of the research, the evaluation...
April 18, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28427795/reappraisal-to-the-study-of-4e-bp1-as-an-mtor-substrate-a-normative-critique
#7
REVIEW
Asiya Batool, Sabreena Aashaq, Khurshid Iqbal Andrabi
mTOR-4E-BP1 axis is regarded as the best oncogenic circuitry impinging on translational control whereby mTORC1 dictates post-translational regulation of 4E-BP1. This review provides new insights into the molecular network of signalling pathways highlighting the recent explosion of studies in respect to the deviant behaviour of 4E-BP1 towards mTORC1. Despite the striking conservation of mTOR nexus, the eccentric phosphorylation dynamics of 4E-BP1 negate the apparent linear architecture of mTORC1 attesting the importance of other kinases that may evoke cross-talks with the conventional frame, most of which are enlisted in the manuscript...
April 8, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28427405/ceiling-effect-in-emr-system-assimilation-a-multiple-case-study-in-primary-care-family-practices
#8
Marie-Claude Trudel, Josianne Marsan, Guy Paré, Louis Raymond, Ana Ortiz de Guinea, Éric Maillet, Thomas Micheneau
BACKGROUND: There has been indisputable growth in adoption of electronic medical record (EMR) systems in the recent years. However, physicians' progress in using these systems has stagnated when measured with maturity scales. While this so-called ceiling effect has been observed and its consequences described in previous studies, there is a paucity of research on the elements that could explain such an outcome. We first suggest that in the context of EMR systems we are in presence of a "tiered ceiling effect" and then we show why such phenomenon occurs...
April 20, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28425515/the-role-of-thermodynamic-stability-in-the-characteristics-of-the-devitrification-front-of-vapour-deposited-glasses-of-toluene
#9
Joan Ràfols-Ribé, Marta Gonzalez-Silveira, Cristian Rodríguez-Tinoco, Javier Rodríguez-Viejo
Physical vapour deposition (PVD) has settled in as an alternative method to prepare glasses with significantly enhanced properties, providing new insights into the understanding of glass transition. One of the striking properties of some PVD glasses is their transformation into liquid via a heterogeneous mechanism that initiates at surfaces/interfaces. Here, we use membrane-based fast-scanning nanocalorimetry (10(4) K s(-1)) to analyse the variables that govern the transformation mechanism of vapour-deposited toluene glasses with different stabilities...
April 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28425293/cosensitized-porphyrin-system-for-high-performance-solar-cells-with-tof-sims-analysis
#10
Wenjun Wu, Huaide Xiang, Wei Fan, Jinglin Wang, Haifeng Wang, Xin Hua, Zhaohui Wang, Yi-Tao Long, He Tian, Wei-Hong Zhu
Up to date, development of organic sensitizers has been predominately focused on light harvesting, HOMO and LUMO energy levels, and electron transferring process. In contrast, their adsorption mode as well as dynamic loading behaviour onto nanoporous TiO2 is rarely considered. Herein we have employed the time of flight secondary ion mass spectrometry (TOF-SIMS) to take insight into the competitive dye adsorption mode and kinetics in cosensitized porphyrin system. Using the novel porphyrin dye FW-1 and D-A-π-A featured dye WS-5, the different bond-breaking mode in TOF-SIMS and dynamic dye-loading amount during the coadsorption process are well compared with two different anchoring groups such as benzoic acid and cyanoacrylic acid...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28424527/unified-alignment-of-protein-protein-interaction-networks
#11
Noël Malod-Dognin, Kristina Ban, Nataša Pržulj
Paralleling the increasing availability of protein-protein interaction (PPI) network data, several network alignment methods have been proposed. Network alignments have been used to uncover functionally conserved network parts and to transfer annotations. However, due to the computational intractability of the network alignment problem, aligners are heuristics providing divergent solutions and no consensus exists on a gold standard, or which scoring scheme should be used to evaluate them. We comprehensively evaluate the alignment scoring schemes and global network aligners on large scale PPI data and observe that three methods, HUBALIGN, L-GRAAL and NATALIE, regularly produce the most topologically and biologically coherent alignments...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421575/-prescribing-psychotropic-medication-by-the-nurse-practitioner-in-mental-health-care-an-explorative-study
#12
E D Rookhuizen, B Stringer, M S Huising, E de Ruijter, B van Meijel
BACKGROUND: Since January 1, 2012, nurse practitioners (NP) working in mental health care are allowed to prescribe psychotropic medication. So far, there has been very little research on the results of this decision that now let NPS share with doctors prescribing psychotropic drugs. AIM: To provide insight into how patients and psychiatrists experience the prescribing behaviours of NPS and how NPS themselves regard their extended role. METHOD: We performed an explorative study in which we used the data given in prescriptions written by NPS, questionnaires exploring patients' experiences and semi-structured interviews with psychiatrists and NPS...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28419170/evaluation-of-the-relative-efficacy-of-a-couple-cognitive-behaviour-therapy-cbt-for-premenstrual-disorders-pmds-in-comparison-to-one-to-one-cbt-and-a-wait-list-control-a-randomized-controlled-trial
#13
Jane M Ussher, Janette Perz
DESIGN: A randomised control trial (RCT) was conducted to examine the efficacy of couple-based cognitive behaviour therapy (CBT) for Premenstrual Disorders (PMDs), in comparison to one-to-one CBT and a wait-list control. METHODS: Triangulation of quantitative and qualitative outcome measures evaluated changes pre-post intervention. Eighty three women were randomly allocated across three conditions, with 63 completing post-intervention measures, a retention rate of 76%...
2017: PloS One
https://www.readbyqxmd.com/read/28418416/-dental-treatment-of-fearful-children-subjection-denyal-or-guidance
#14
M C M van Gemert-Schriks, M M Bildt
Dental treatment anxiety is a common fear among children. The dental health care provider is faced with difficult dilemmas about ensuring good oral health for these children in general daily practice. The indicated treatment usually exceeds the capacity of the frightened child, but when treatment is not performed, the child is at risk of serious general health problems and its quality of life could diminish. This article provides an overview of the aetiology of dental treatment anxiety in children. In addition, the dental practitioner is provided with insight into the possibilities that allow him/her to enhance the treatability of the child and reduce anxiety to such an extent that the indicated dental care can be provided...
April 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28418242/slow-but-steady-wins-the-race-dissimilarities-among-new-dual-inhibitors-of-the-wild-type-and-the-v27a-mutant-m2-channels-of-influenza-a-virus
#15
Marta Barniol-Xicota, Sabrina Gazzarrini, Eva Torres, Yanmei Hu, Jun Wang, Lieve Naesens, Anna Moroni, Santiago Vázquez
New insights on the amantadine resistance mechanism of the V27A mutant were obtained through the study of novel, easily accessible 4-(1- and 2-adamantyl)piperidines, identified as dual binders of the wild-type and V27A mutant M2 channels of influenza A virus. Their antiviral activity and channel blocking ability were determined using cell-based assays and two-electrode voltage clamp (TEVC) technique on M2 channels, respectively. In addition, electrophysiology experiments revealed two interesting findings: (i) these inhibitors display a different behavior against the wild-type versus V27A mutant A/M2 channels, and (ii) the compounds display antiviral activity when they have kd equal or smaller than 10(-6) while they do not exhibit antiviral activity when kd is 10(-5) or higher although they may show blocking activity in the TEV assay...
April 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28413998/optimising-treatment-strategies-for-adhd-in-adolescence-to-minimise-lost-in-transition-to-adulthood
#16
J K Buitelaar
The persistence of attention-deficit hyperactivity disorder (ADHD) from adolescence to adulthood is not matched by continuity of care in this transition period. Many adolescents with ADHD have poor medication adherence or even stop medication treatment, and use of behavioural interventions is also suboptimal. The present commentary focuses on treatment strategies that might improve effects of ADHD medication treatment by improving adherence in adolescents with ADHD and/or optimise behavioural interventions for ADHD in adolescence...
April 17, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28413342/identifying-the-significance-of-nonlinear-normal-modes
#17
T L Hill, A Cammarano, S A Neild, D A W Barton
Nonlinear normal modes (NNMs) are widely used as a tool for understanding the forced responses of nonlinear systems. However, the contemporary definition of an NNM also encompasses a large number of dynamic behaviours which are not observed when a system is forced and damped. As such, only a few NNMs are required to understand the forced dynamics. This paper firstly demonstrates the complexity that may arise from the NNMs of a simple nonlinear system-highlighting the need for a method for identifying the significance of NNMs...
March 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28411579/self-injury-and-aggression-in-adults-with-tuberous-sclerosis-complex-frequency-associated-person-characteristics-and-implications-for-assessment
#18
Lucy Wilde, Kate Eden, Petrus de Vries, Jo Moss, Alice Welham, Chris Oliver
Even though self-injury and aggression are common in tuberous sclerosis complex (TSC), understanding of these behaviours in adults with TSC and intellectual disability (ID) is limited. Little is known about their frequency in comparison to other ID-related genetic disorders or their association with other TSC-Associated Neuropsychiatric Disorders (TAND). This study determined the caregiver-reported frequency of self-injury and aggression in adults with TSC plus ID in comparison to Down syndrome (DS) and Angelman syndrome (AS), and assessed demographic and behavioural characteristics associated with the occurrence of each behaviour in TSC...
April 12, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28411030/a-critical-and-interpretive-literature-review-of-birthing-women-s-non-elicited-pain-language
#19
Stephanie Power, Fiona E Bogossian, Roland Sussex, Jenny Strong
BACKGROUND: Standardised pain assessment i.e. the McGill Pain Questionnaire provide an elicited pain language. Midwives observe spontaneous non-elicited pain language to guide their assessment of how a woman is coping with labour. This paper examined the labour pain experience using the questions: What type of pain language do women use? Do any of the words match the descriptors of standardised pain assessments? What type of information doverbal and non-verbal cues provide to the midwife? METHODS: A literature search was conducted in 2013...
April 12, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28404867/dynamic-cellular-finite-element-method-for-modelling-large-scale-cell-migration-and-proliferation-under-the-control-of-mechanical-and-biochemical-cues-a-study-of-re-epithelialization
#20
Jieling Zhao, Youfang Cao, Luisa A DiPietro, Jie Liang
Computational modelling of cells can reveal insight into the mechanisms of the important processes of tissue development. However, current cell models have limitations and are challenged to model detailed changes in cellular shapes and physical mechanics when thousands of migrating and interacting cells need to be modelled. Here we describe a novel dynamic cellular finite-element model (DyCelFEM), which accounts for changes in cellular shapes and mechanics. It also models the full range of cell motion, from movements of individual cells to collective cell migrations...
April 2017: Journal of the Royal Society, Interface
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