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Diabetic gastroparesis

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https://www.readbyqxmd.com/read/27914942/is-there-a-role-for-ghrelin-in-central-dopaminergic-systems-focus-on-nigrostriatal-and-mesocorticolimbic-pathways
#1
REVIEW
Alicia Stievenard, Mathieu Méquinion, Zane B Andrews, Alain Destée, Marie-Christine Chartier-Harlin, Odile Viltart, Christel C Vanbesien-Mailliot
The gastro-intestinal peptide ghrelin has been assigned many functions. These include appetite regulation, energy metabolism, glucose homeostasis, intestinal motility, anxiety, memory or neuroprotection. In the last decade, this pleiotropic peptide has been proposed as a therapeutic agent in gastroparesis for diabetes and in cachexia for cancer. Ghrelin and its receptor, which is expressed throughout the brain, play an important role in motivation and reward. Ghrelin finely modulates the mesencephalic dopaminergic signaling and is thus currently studied in pathological conditions including dopamine-related disorders...
November 30, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27882650/a-qualitative-assessment-of-west-virginia-pharmacist-activities-and-attitude-in-diabetes-management
#2
Aymen Shatnawi, David A Latif
AIMS AND OBJECTIVES: The role of pharmacists in chronic disease state management has been shown to significantly improve patient health outcomes and reduce overall health care costs. The current study is designed to assess the roles and attitudes of West Virginia (WV) pharmacists toward diabetes, evaluate services provided, address pharmacist clinical understanding and training, and demonstrate the challenges that limit pharmacists ability to deliver an efficient disease state management...
November 24, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27820956/the-association-between-fasting-c-peptide-and-gastrointestinal-symptoms-of-gastroparesis-in-type-2-diabetic-patients
#3
Yun Huang, Honghong Zhang, Minxia Zhang, Wenya Li, Jinhua Wang, Ji Hu
Background/Aims: The relationship between c-peptide levels and gastrointestinal (GI) symptoms in type 2 diabetic patients is not clear. The purpose of this study is to examine the association between fasting C-peptide and GI symptoms of gastroparesis in type 2 diabetic patients. Methods: We recruited 333 type 2 diabetic patients into the present study. All the patients filled out questionnaires of gastroparesis cardinal symptom index (GCSI) to evaluate GI symptoms...
November 7, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27795979/interleukin-10-restores-gastric-emptying-electrical-activity-and%C3%A2-interstitial-cells-of-cajal-networks-in-diabetic-mice
#4
Kyoung Moo Choi, Simon J Gibbons, Lei Sha, Arthur Beyder, Pieter-Jan Verhulst, Gianluca Cipriani, Jessica E Phillips, Anthony J Bauer, Tamas Ordog, Jon J Camp, Xin Ge, Adil E Bharucha, David R Linden, Joseph H Szurszewski, Purna C Kashyap, Gianrico Farrugia
BACKGROUND & AIMS: Gastroparesis is a complication of diabetes characterized by delayed emptying of stomach contents and accompanied by early satiety, nausea, vomiting, and pain. No safe and reliable treatments are available. Interleukin 10 (IL10) activates the M2 cytoprotective phenotype of macrophages and induces expression of heme oxygenase 1 (HO1) protein. We investigated whether IL10 administration could improve gastric emptying and reverse the associated cellular and electrical abnormalities in diabetic mice...
July 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27785328/measures-of-autonomic-dysfunction-in-diabetic-and-idiopathic-gastroparesis
#5
Mohammad Khalid Mohammad, Dominique J Pepper, Archana Kedar, Feriyl Bhaijee, Babajide Familoni, Hani Rashed, Teresa Cutts, Thomas L Abell
BACKGROUND: Gastroparesis is a condition classically characterized by delayed gastric emptying and is associated with considerable morbidity. While the etiology of gastroparesis remains elusive, autonomic dysfunction may play an important role, especially as many patients with gastroparesis also have diabetes. The aim of this study was to determine whether measures of autonomic function differ between adults with diabetic gastroparesis (DG) and adults with idiopathic gastroparesis (IG)...
October 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27785323/increased-expression-of-pyloric-er%C3%AE-is-associated-with-diabetic-gastroparesis-in-streptozotocin-induced-male-diabetic-rats
#6
Stephen Crimmins, Rebecca Smiley, Kerry Preston, Amy Yau, Richard Mccallum, Mohammed Showkat Ali
BACKGROUND: Gastroparesis is a significant co-morbidity affecting up to 50% of patients with diabetes and is disproportionately found in women. Prior studies have suggested that loss of interstitial cells of Cajal, hyperglycemia, and nitric oxide dysfunction are potential causes of gastroparesis. Since diabetic gastroparesis affects more women than men, we performed an exploratory study with a diabetic rat model to determine if sex hormone signaling is altered in those where gastroparesis develops...
June 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27785318/autonomic-evaluation-of-patients-with-gastroparesis-and-neurostimulation-comparisons-of-direct-systemic-and-indirect-cardiac-measures
#7
Abigail Stocker, Thomas L Abell, Hani Rashed, Archana Kedar, Ben Boatright, Jiande Chen
BACKGROUND: Disorders of nausea, vomiting, abdominal pain, and related problems often are manifestations of gastrointestinal, neuromuscular, and/or autonomic dysfunction. Many of these patients respond to neurostimulation, either gastric electrical stimulation or electroacupuncture. Both of these therapeutic techniques appear to influence the autonomic nervous system which can be evaluated directly by traditional testing and indirectly by heart rate variability. METHODS: We studied patients undergoing gastric neuromodulation by both systemic autonomic testing (39 patients, six males and 33 females, mean age 38 years) and systemic autonomic testing and heart rate variability (35 patients, seven males and 28 females, mean age 37 years) testing before and after gastric neuromodulation...
February 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27781342/early-satiety-and-postprandial-fullness-in-gastroparesis-correlate-with-gastroparesis-severity-gastric-emptying-and-water-load-testing
#8
H P Parkman, E K Hallinan, W L Hasler, G Farrugia, K L Koch, L Nguyen, W J Snape, T L Abell, R W McCallum, I Sarosiek, P J Pasricha, J Clarke, L Miriel, J Tonascia, F Hamilton
BACKGROUND: Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing. METHODS: Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and quality of life (PAGI-QOL, SF-36v2)...
October 25, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27781339/tumor-necrosis-factor-alpha-derived-from-classically-activated-m1-macrophages-reduces-interstitial-cell-of-cajal-numbers
#9
S T Eisenman, S J Gibbons, P-J Verhulst, G Cipriani, D Saur, G Farrugia
BACKGROUND: Delayed gastric emptying in diabetic mice and humans is associated with changes in macrophage phenotype and loss of interstitial cells of Cajal (ICC) in the gastric muscle layers. In diabetic mice, classically activated M1 macrophages are associated with delayed gastric emptying, whereas alternatively activated M2 macrophages are associated with normal gastric emptying. This study aimed to determine if secreted factors from M1 macrophages could injure mouse ICC in primary culture...
October 25, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27775961/gastroparesis-quality-of-life-and-health-care-utilization
#10
Brian E Lacy, Michael D Crowell, Carole Mathis, David Bauer, Leslie J Heinberg
BACKGROUND AND AIMS: Gastroparesis (GP) patients suffer from recurrent symptoms of nausea, vomiting, early satiety, and abdominal pain. The impact of GP on quality of life (QoL), health care utilization and daily activities is not well understood. MATERIALS AND METHODS: Part 1: 398 adult patients (≥18 y) with documented GP (symptoms >6 mo) were surveyed to assess QoL and pain using the Short Form 36 and McGill pain questionnaires. Part 2: 491 adult GP patients were surveyed to evaluate employment status, work and daily activities, medication use, physician visits, diagnostic testing, emergency room visits, and hospitalizations related to their GP symptoms...
October 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27759430/evaluation-of-gastric-blood-supply-in-diabetic-patients-with-gastroparesis-by-contrast-enhanced-ultrasound
#11
Hao-Lin Shen, Shu-Ping Yang, Kang-Jian Wang, Bei-Lei Huang, Wen-Bao Huang, Jin-Zhi Wu, Guo-Rong Lv
OBJECTIVE: Improvement in regional blood flow has been shown to ameliorate diabetic gastroparesis. We compared the gastric blood supply in patients with diabetes with gastroparesis with that in healthy subjects, by using contrast-enhanced ultrasound (CEUS). METHODS: 30 healthy subjects and 40 patients with diabetic gastroparesis were enrolled. The CEUS parameters of greater curvatures of the antrum (GCOA) and lesser curvatures of the antrum (LCOA), including peak intensity (PI) and the area under the curve (AUC), were compared between the two groups...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27727602/role-and-efficacy-of-chronic-intermittent-insulin-intravenous-infusion-therapy-ciiit-in-patients-with-diabetic-gastroparesis
#12
Suryakamal, P K Maheshwari
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27696071/treatment-of-diabetic-gastroparesis-with-botulinum-toxin-injection-guided-by-endoscopic-ultrasound-in-a-patient-with-type-1-diabetes-the-first-report
#13
Heming Guo, Chen Fang, Yun Huang, Honghong Zhang, Xiaohong Chen, Duanming Hu, Ji Hu
No abstract text is available yet for this article.
October 1, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27678506/gastric-electrical-stimulation-for-gastroparesis-and-chronic-unexplained-nausea-and-vomiting
#14
REVIEW
John M Wo, Thomas V Nowak, Shamaila Waseem, Matthew P Ward
Gastroparesis is a heterogeneous clinical syndrome. Some patients have debilitating vomiting, weight loss, and dehydration, while others have effortless regurgitation of undigested foods or postprandial distress suggestive of functional dyspepsia. Gastric electrical stimulation (GES) has been proposed as an effective treatment option for patients with gastroparesis refractory to medical therapy. Evidence suggests that the clinically available device, a low-energy high-frequency GES, activates the vagal afferent pathways to influence the central control mechanisms for nausea and vomiting...
December 2016: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/27667549/prevalence-and-predictors-of-delayed-gastric-emptying-among-indian-patients-with-long-standing-type-2-diabetes-mellitus
#15
Venkata Anudeep, Kolar Vishwanath Vinod, Nandini Pandit, Vivek Kumar Sharma, Halanaik Dhanapathi, Tarun Kumar Dutta, Akkilagunta Sujiv
BACKGROUND AND AIMS: Upper gastrointestinal symptoms are more prevalent among type 2 diabetes mellitus (T2DM) patients. The prevalence of delayed gastric emptying (GE) and factors predictive of it have not been studied in Indian T2DM patients and the present study aimed to study the same. METHODS: This hospital-based cross-sectional study involved adult (age between 18 and 65 years) outpatients with T2DM of ≥5-year duration. Measurements of GE of a labelled standardized solid rice idli meal by gastric emptying scintigraphy (GES), symptoms of delayed GE (by standardized questionnaire) and autonomic function by cardiovascular autonomic function tests (AFTs) were carried out...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27610063/prevalence-and-risk-factors-of-gastroparesis-related-symptoms-among-patients-with-type-2-diabetes
#16
Rakan A Almogbel, Fulwa A Alhussan, Sulaiman A Alnasser, Metab A Algeffari
BACKGROUND: The prevalence of gastroparesis in type 2 diabetes mellitus (T2DM) vary widely. Our aim is to estimate the prevalence of clinical symptoms of gastroparesis among patients with type 2 diabetes mellitus and explore the relationship between gastroparesis and other risk factors. METHODS: A cross-sectional study evaluating 147 type 2 diabetics using the Gastroparesis Cardinal Symptoms Index (GCSI). A GCSI Total Score ≥ 1.90 were chosen as having definite symptoms of gastroparesis...
July 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27590947/microangiopathy-and-pregnancy
#17
Said Azzoug, Farida Chentli
Diabetic microangiopathy is a frequent complication of longstanding diabetes mellitus. Micro vascular lesions may have severe implications for both maternal and foetal health. Patients with advanced underlying lesions are at increased risk of progression during pregnancy. Severe retinal lesions can progress during pregnancy and one year after delivery. Poor glycaemic control prior to conception and rapid improvement during pregnancy are other risk factors of progression. Treatment of lesions with high risk of progression and progressive blood glucose lowering in the preconception period can improve the prognosis...
September 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27582154/microangiopathy-and-pregnancy
#18
Said Azzoug, Farida Chentli
Diabetic microangiopathy is a frequent complication of longstanding diabetes mellitus. Micro vascular lesions may have severe implications for both maternal and foetal health. Patients with advanced underlying lesions are at increased risk of progression during pregnancy. Severe retinal lesions can progress during pregnancy and one year after delivery. Poor glycaemic control prior to conception and rapid improvement during pregnancy are other risk factors of progression. Treatment of lesions with high risk of progression and progressive blood glucose lowering in the preconception period can improve the prognosis...
September 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27563696/esophageal-and-gastric-dysmotilities-are-associated-with-altered-glucose-homeostasis-and-plasma-levels-of-incretins-and-leptin
#19
Rebecka Hammersjö, Bodil Roth, Peter Höglund, Bodil Ohlsson
BACKGROUND: Gastrointestinal complications in diabetes may affect glucose and endocrine homeostasis. Glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), and leptin regulate glucose homeostasis, food intake, and gastric emptying. AIM: The aim was to investigate associations between diabetes complications and glucose homeostasis and plasma levels of GIP, GLP-1, and leptin. METHODS: Sixteen diabetes patients (seven men) were examined with gastric emptying scintigraphy and 72-h continuous subcutaneous glucose monitoring, 14 with the deep-breathing test, and 12 with esophageal manometry...
2016: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/27530760/domperidone-to-treat-symptoms-of-gastroparesis-benefits-and-side-effects-from-a-large-single-center-cohort
#20
Ron Schey, Mohammed Saadi, Deena Midani, Aaron C Roberts, Rahul Parupalli, Henry P Parkman
BACKGROUND: There is increased awareness about risks and benefits of using domperidone to treat gastroparesis. AIM: To describe the outcome of treating patients with refractory gastroparesis symptoms with domperidone. METHODS: Domperidone 10 mg QID or TID was prescribed to patients with refractory gastroparesis symptoms; follow-up obtained at 2-3 months assessing symptoms and side effects. Patients filled out Patient Assessment of Upper GI Symptoms prior to treatment and at follow-up along with Clinical Patient Grading Assessment Scale (CPGAS, +7 = completely better; 0 = no change)...
December 2016: Digestive Diseases and Sciences
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