keyword
https://read.qxmd.com/read/38533281/efficacy-of-pistacia-lentiscus-plant-rumi-mastagi-in-comparison-to-levosulpiride-in-patients-with-diabetic-gastroparesis-a-double-blind-non-inferior-randomised-control-trial-study
#1
JOURNAL ARTICLE
Ajaypal Singh, Ravi Kant, Rohit Raina, Vandana Dhingra, Rajeev Nema, Mukesh Chand Bairwa, Varsha Kanwar, Rifika L Sukhes Mukherjee, Anissa Atif Mirza, Mayank Agarwal
INTRODUCTION: Gastrointestinal neuropathies are frequently found in diabetic patients. The pathogenesis of diabetic gastroparesis (DG) is multifactorial. The usual treatment for DG includes dietary modifications, prokinetic and antiemetic agents. There is increasing demand for more effective medicines to treat DG. The current study was conducted on the Pistacia lentiscus stem extract to add to the armamentarium of DG treatment and to find the efficacy of P. lentiscus plant extract (mastic gum) in comparison to levosulpiride in DG for improvement in gastroparesis symptoms and gastric emptying scintigraphy (GES) in a single centric double-blind non-inferiority randomised control trial...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38513416/misdiagnosed-superior-mesenteric-artery-syndrome-due-to-diabetic-gastroparesis-case-report-and-literature-review
#2
Jair Díaz-Martínez, Francisco Tomás Hizojo-Aloé, Renata Jimena Rivera-Chávez, Nidia Alejandra González-Hernández
INTRODUCTION: Superior mesenteric artery syndrome (SMAS) is a rare cause of upper intestinal obstruction. This occurs due to duodenal compression between the superior mesenteric artery and the aorta. Anatomical alterations, eating disorders, after some surgical procedures, and trauma are frequent causes of this rare syndrome. Diabetes is a highly prevalent disease that can cause gastroparesis in up to 12 %. Its association with SMAS is extremely rare and challenging to identify. CASE PRESENTATION: A 32-year-old man experienced nausea and vomiting after diagnosis and treatment for type II diabetes...
March 19, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38497371/diabetic-gastroparesis-a-disease-for-which-long-term-therapeutic-benefits-are-difficult-to-obtain
#3
JOURNAL ARTICLE
Jun Zhou, Sha Li Ran, Ying Chang Zhao
The pathophysiology of diabetic gastroparesis (DGP), a common complication in diabetic patients, is not fully known. Its development has been linked to several causes, including hyperglycaemia, vagal nerve dysfunction, aberrant Cajal's interstitial cell network (ICC), lack of nerve nitric oxide synthase (nNOS) expression in the intermuscular plexus, and hormonal alterations in the gastrointestinal tract. Glucose management, diet control, gastric stimulants, anti-emetic medications, Helicobacter pylori eradication, stomach electrical stimulation, and surgery are the main current treatments...
March 18, 2024: Endokrynologia Polska
https://read.qxmd.com/read/38488234/huanglian-banxia-promotes-gastric-motility-of-diabetic-rats-by-modulating-brain-gut-neurotransmitters-through-mapk-signaling-pathway
#4
JOURNAL ARTICLE
Wei Chen, Qiong Chen, Jiayi Huang, Xianmin Shen, Lurong Zhang, Guorong Jiang, Tingting Wu, Fei Wang, Xudong Cheng
BACKGROUND: Gastric motility disorder is an increasingly common problem among people with diabetes. Neurotransmitters have been recognized as critical regulators in the process of gastric motility. Previous study has shown that herb pair huanglian-banxia (HL-BX) can improve gastric motility, but the underlying mechanism is still unclear. The aim of this study was to further investigate the role of HL-BX in modulating brain-gut neurotransmission to promote gastric motility in diabetic rats, and to explore its possible mechanism...
March 15, 2024: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/38485835/association-of-glucagon-like-peptide-receptor-1-agonist-therapy-with-the-presence-of-gastric-contents-in-fasting-patients-undergoing-endoscopy-under-anesthesia-care-a-historical-cohort-study
#5
JOURNAL ARTICLE
Fei Wu, Matthew R Smith, Ariel L Mueller, Seth A Klapman, Lucinda L Everett, Timothy Houle, Braden Kuo, Ion A Hobai
PURPOSE: We aimed to estimate the association of glucagon-like peptide 1 (GLP-1) receptor agonist therapy with the incidence of endoscopically visible gastric contents after preprocedural fasting. METHODS: We reviewed the records of esophagogastroduodenoscopy (EGD) performed at our institution between 2019 and 2023 and determined the presence of residual gastric contents from the procedure notes and saved images. We compared patients taking GLP-1 agonists at the time of the procedure (GLP group, 90 procedures) with patients who started GLP-1 agonist therapy within 1,000 days after undergoing EGD (control, 102 procedures)...
March 14, 2024: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/38462479/the-critical-role-of-muscularis-macrophages-in-modulating-the-enteric-nervous-system-function-and-gastrointestinal-motility
#6
REVIEW
Egan L Choi, Negar Taheri, Yuebo Zhang, Kenjiro Matsumoto, Yujiro Hayashi
Macrophages are the originators of inflammatory compounds, phagocytic purifiers in their local environment, and wound healing protectors in oxidative environments. They are molded by the tissue milieu they inhabit, with gastrointestinal (GI) muscularis macrophages (MMs) being a prime example. MMs are located in the muscular layer of the GI tract and contribute to muscle repair and maintenance of GI motility. MMs are often in close proximity to the enteric nervous system, specifically near the enteric neurons and interstitial cells of Cajal (ICCs)...
2024: Journal of Smooth Muscle Research
https://read.qxmd.com/read/38454582/real-world-safety-and-effectiveness-of-pistacia-lentiscus-mastic-gum-in-patients-with-diabetic-gastroparesis-24-week-interim-analysis-postintervention
#7
JOURNAL ARTICLE
Ravi Kant, Ajaypal Singh, Rohit Raina, Vandana Dhingra, Mukesh Bairwa, Varsha Kanwar
INTRODUCTION: Gastrointestinal neuropathies are frequently found in diabetic patients. AIM: The aim of this study was to find out the safety, adverse reactions, and long-term effectiveness of Pistacia lentiscus plant extract (mastic gum) in diabetic gastroparesis (DG) with respect to sustainable improvement in gastroparesis symptoms (Gastrointestinal Cardinal Symptom Index [GCSI] score) by observational follow-up study of a single-centric double-blind noninferiority randomized control trial...
January 1, 2024: Indian Journal of Pharmacology
https://read.qxmd.com/read/38453938/sex-specific-epigenetics-drive-low-gper-expression-in-gastrointestinal-smooth-muscles-in-type-2-diabetic-mice
#8
JOURNAL ARTICLE
Aliyu Muhammad, Juanita C Hixon, Abdurrahman Pharmacy Yusuf, Jatna I Rivas Zarete, India Johnson, Jamial Miller, Benjamin Adu-Addai, Clayton Yates, Sunila Mahavadi
Type 2 diabetes mellitus (T2D) causes gastroparesis, delayed intestinal transit, and constipation, for unknown reasons. Complications are predominant in women than men (particularly pregnant and postmenopausal women), suggesting a female hormone-mediated mechanism. Low G-protein coupled estrogen receptor (GPER) expression from epigenetic modifications may explain it. We explored sexually differentiated GPER expression and gastrointestinal symptoms related to GPER alterations in wild-type (WT) and T2D mice (db/db)...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38443110/universal-fasting-glucose-screening-before-gastric-emptying-scintigraphy-and-the-high-prevalence-of-undiagnosed-diabetes-and-prediabetes
#9
JOURNAL ARTICLE
Rutger S Gunther, Kevin P Banks, Nathan E McWhorter
The aim of this study was to assess the rates of undiagnosed diabetes mellitus (DM) and pre-DM in patients undergoing gastric emptying scintigraphy (GES). Diabetes is an epidemic in the United States, and the disease is associated with altered gut motility. As a result, we suspected that a significant number of patients referred for GES may have undiagnosed DM or pre-DM. Given that established procedure standards for GES require all patients to prepare with an 8-h fast, an opportunity is provided to measure the fasting blood glucose (FBG) in all individuals before they undergo the examination...
March 5, 2024: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/38443105/glucagonlike-peptide-1-receptor-agonists-the-good-the-bad-and-the-ugly-benefits-for-glucose-control-and-weight-loss-with-side-effects-of-delaying-gastric-emptying
#10
JOURNAL ARTICLE
Henry P Parkman, Daniel S Rim, Jonathan R Anolik, Simin Dadparvar, Alan H Maurer
Glucagonlike peptide-1 (GLP-1) receptor agonists (RAs) are being increasingly used for glycemic control in patients with diabetes and for weight loss and weight management in obese subjects. There has been recent public awareness of the potential of GLP-1 RAs to delay gastric emptying and cause gastroparesis. By delaying gastric emptying, these agents can complicate the clinical evaluation of patients on these drugs by affecting diagnostic testing for gastroparesis. This article discusses GLP-1 RAs and their effects on gastric emptying, gastric food retention, and gastroparesis...
March 5, 2024: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/38419246/a-gluco-mindful-approach-to-diabetic-gastroparesis
#11
JOURNAL ARTICLE
Sanjay Kalra, Saptarshi Bhattacharya, Hitesh Punyani
Diabetes gastroparesis is a common manifestation of autonomic neuropathy in persons with long-standing, uncontrolled diabetes. Most discussion about its management revolves around the mitigation of symptoms. Here, we share tips on choosing the right glucose-lowering medication, based upon predominant symptomatology of gastroparesis. We highlight about insulin preparations, and their timing of administration, can be tailored according to need. We also emphasize the need to choose oral glucose lowering drugs with care...
February 2024: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38399414/glucagon-like-peptide-1-receptor-agonists-associated-gastrointestinal-adverse-events-a-cross-sectional-analysis-of-the-national-institutes-of-health-all-of-us-cohort
#12
JOURNAL ARTICLE
Wafa Ali Aldhaleei, Tadesse M Abegaz, Akshaya Srikanth Bhagavathula
BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are commonly used diabetes and obesity medications but have been associated with gastrointestinal (GI) adverse events. However, real-world evidence on comparative GI adverse reaction profiles is limited. OBJECTIVES: This study aimed to evaluate GI adverse events among GLP-1 RA users and compare semaglutide, dulaglutide, liraglutide, and exenatide safety regarding the GI adverse reaction profile. METHODS: This retrospective cross-sectional analysis utilized real-world data on 10,328 adults with diabetes/obesity in the National Institutes of Health All of Us cohort...
February 2, 2024: Pharmaceuticals
https://read.qxmd.com/read/38390180/risk-factor-analysis-and-nomogram-for-predicting-gastroparesis-in-patients-with-type-2-diabetes-mellitus
#13
JOURNAL ARTICLE
Hai-Liang Yuan, Xian Zhang, Wei-Wei Chu, Guan-Bin Lin, Chun-Xia Xu
PURPOSE: The incidence of gastroparesis is higher in individuals diagnosed with type 2 diabetes mellitus (T2DM) compared to the healthy individuals. Our study aimed to explore the risk factors for gastroparesis in T2DM and to establish a clinical prediction model (nomogram). METHODS: Our study enlisted 694 patients with T2DM from two medical centers over a period of time. From January 2020 to December 2022, 347 and 149 patients were recruited from the Beilun branch of Zhejiang University's First Affiliated Hospital in the training and internal validation cohorts, respectively...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38376247/preliminary-study-on-the-dynamic-positron-emission-tomography-imaging-with-11-c-er176-to-delineate-macrophage-activation-in-diabetic-gastroparesis
#14
JOURNAL ARTICLE
Elisia Maalouf, Hala Khasawneh, Aashna Karbhari, Shefaa AlAsfoor, Margaret Breen-Lyles, Cheryl Bernard, Elizabeth Rajan, Gianrico Farrugia, Val Lowe, Ajit Goenka, Madhusudan Grover
BACKGROUND: Animal models and human data have suggested macrophage-driven immune dysregulation in diabetic gastroparesis (DG). Translocator protein (TSPO) upregulation has been suggested to indicate activated state of macrophages and ER176 is a high affinity third generation TSPO-specific radioligand. The aim of this study was to determine feasibility of dynamic 11 C-ER 176 PET to identify macrophage activation in DG. METHODS: Twelve patients, all females, were recruited (4 DG, 4 diabetics, and 4 healthy volunteers) for 11 C-ER 176 PET/CT scanning...
February 20, 2024: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/38371020/tendency-of-semaglutide-to-induce-gastroparesis-a-case-report
#15
Ahtshamullah Chaudhry, Buluku Gabriel, Jawad Noor, Saima Jawad, Suryanarayana R Challa
Semaglutide, an agonist of the glucagon-like peptide-1 receptor, is frequently used in the treatment of diabetes mellitus type 2, although, lately, weight loss has additionally become a reason for its use. However, if a patient is already experiencing bloating, nausea, abdominal pain, and discomfort in the abdomen, it is not recommended to use it due to concern about aggravating these symptoms. Although it is often well tolerated, there are occasions when it can have several gastrointestinal side effects. Therefore, we report a case of a patient who started taking semaglutide and later developed gastroparoresis...
January 2024: Curēus
https://read.qxmd.com/read/38327939/safety-and-efficacy-of-highly-selective-5-hydroxytryptamine-receptor-4-agonists-for-diabetic-and-idiopathic-gastroparesis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
REVIEW
Parth Patel, Eli A Zaher, Himsikhar Khataniar, Mohamed A Ebrahim, Priyadarshini Loganathan
Gastroparesis significantly affects quality of life and healthcare expenditure. Effective treatment options are limited, and the utility of current prokinetic agents is inhibited by serious adverse effects. There exists an unmet need for prokinetic agents demonstrating both efficacy and an acceptable adverse effect profile. Highly selective 5-Hydroxytryptamine receptor 4 (5-HT4) agonists have exhibited clinical efficacy and safety in randomized controlled trials (RCTs). Consequently, we conducted a meta-analysis to comprehensively assess the safety and efficacy of these highly selective agents...
January 2024: Curēus
https://read.qxmd.com/read/38285516/spectrum-of-diabetic-neuropathy-new-insights-in-diagnosis-and-treatment
#17
REVIEW
Brendan R Dillon, Lynn Ang, Rodica Pop-Busui
Diabetic neuropathy is a highly prevalent complication of diabetes. It consists of a broad range of neuropathic conditions, such as distal symmetric polyneuropathy and various forms of autonomic neuropathies involving the cardiovascular, gastrointestinal, and urogenital systems. Prevention or diagnosis in early stages of disease is crucial to prevent symptomatic onset and progression, particularly in the absence of current disease-modifying therapies. In this review, we describe the four main types of diabetic neuropathy...
January 29, 2024: Annual Review of Medicine
https://read.qxmd.com/read/38280660/a-officinarum-hance-p-cablin-blanco-benth-drug-pair-improves-oxidative-stress-intracellular-ca-2-concentrations-and-apoptosis-by-inhibiting-the-age-rage-axis-to-ameliorate-diabetic-gastroparesis-in-vitro-and-in-vivo-studies
#18
JOURNAL ARTICLE
Xiuwen Zheng, Qianrong Xue, Yinghuan Wang, Lu Lu, Yipeng Pan, Jian Xu, Junqing Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Alpinia officinarum Hance is a perennial natural medicine herbivorous plant, has been used in the management of treat stomach pain and diabetes, it is abundantly cultivated in Qiongzhong, Baisha and other places. P. cablin (Blanco) Benth, one of the most important traditional Chinese plants, which plays functions in antioxidant and gastrointestinal regulation, has been extensively planted in Hainan, Guangdong and other regions. AIM OF THE STUDY: In this study, we investigated the role and underlying molecular mechanism of AP on diabetic gastroparesis (DGP) in vitro and in vivo...
January 25, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38237696/the-efficacy-of-tradipitant-in-patients-with-diabetic-and-idiopathic-gastroparesis-in-phase-iii-randomized-placebo-controlled-clinical-trial
#19
JOURNAL ARTICLE
Jesse L Carlin, Christos Polymeropoulos, Michael Camilleri, Anthony Lembo, Michaela Fisher, Caleigh Kupersmith, Darby Madonick, Paula Moszczynski, Sandra Smieszek, Changfu Xiao, Gunther Birznieks, Mihael H Polymeropoulos
BACKGROUND: Neurokinin receptor 1 (NK1R) antagonists are effective in reducing nausea and vomiting in chemo-therapy induced emesis. We investigated the safety and efficacy of tradipitant, an NK1R antagonist, in patients with idiopathic and diabetic gastroparesis. METHODS: 201 adults with gastroparesis were randomly assigned to oral tradipitant 85 mg (n = 102) or placebo (n = 99) twice daily for 12 weeks. Symptoms were assessed by a daily symptom dairy, Gastroparesis Cardinal Symptom Index scores, and other patient-reported questionnaires...
January 16, 2024: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/38212710/gastroparesis-might-not-be-uncommon-in-patients-with-diabetes-mellitus-in-a-real-world-clinical-setting-a-cohort-study
#20
JOURNAL ARTICLE
Jeongmin Lee, Hye Lim Park, Su Young Park, Chul-Hyun Lim, Min-Hee Kim, Jung Min Lee, Sang-Ah Chang, Jung-Hwan Oh
BACKGROUND: This study investigated the frequency of diabetic gastroparesis and associated risk factors in a real-world clinical setting. METHODS: This retrospective cross-sectional study included patients who underwent assessments of solid gastric emptying time (GET) by technetium-99 m scintigraphy between May 2019 and December 2020. We categorized patients into three groups according to gastric retention of technetium-99 m: rapid (< 65% at 1 h or < 20% at 2 h), normal (≤60% at 2 h and/or ≤ 10% at 4 h), and delayed (> 60% at 2 h and/or > 10% at 4 h)...
January 11, 2024: BMC Gastroenterology
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