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https://www.readbyqxmd.com/read/28945062/early-recanalization-of-veins-in-patients-with-dvt-treated-with-rivaroxaban-do-we-need-to-move-from-bedside-to-bench-again
#1
Eduardo Ramacciotti, Giuliano Giova Volpiani, Ronaldo Dávila, Valeria C Resende Aguiar, Jawed Fareed
Rivaroxaban is one of the direct non-vitamin K antagonists (DOACs) that is globally approved for single drug approach to treat venous thromboembolism (VTE). Its usage is growing quickly, given the practicality of single daily dose, no need for monitoring and a better safety profile compared with that of vitamin K antagonists (VKA). As real world experience with rivaroxaban accumulates, isolated reports regarding its ability to promote earlier and more intense venous recanalization compared with VKA treatment have been published...
September 22, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28945056/the-changing-landscape-of-ependymomas-diagnostic-and-treatment-approaches
#2
Isabelle M Germano, Ekkehard M Kasper
No abstract text is available yet for this article.
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945053/surgery-for-posterior-fossa-ependymomas-in-adults
#3
Yosef Laviv, Isabelle M Germano, Anand Mahadevan, Ekkehard M Kasper
Ependymomas of the posterior fossa in adults are relatively rare, represent less than 1% of adult intracranial gliomas. Most of the cases are WHO grade II. Due to their rarity, there are no randomized studies regarding the best management of these tumors. It seems that surgical resection has a major role in their management. Unlike the scenario in children, these tumors can be cured by gross total resection without adjuvant therapy in the majority of cases. Hence, knowing the different surgical approaches, with their pros and cons, is important in order to offer the patient the best treatment...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945052/negative-influence-of-preoperative-tinnitus-on-hearing-preservation-in-vestibular-schwannoma-surgery
#4
Luciano Mastronardi, Guglielmo Cacciotti, Raffaellino Roperto, Ettore DI Scipio
BACKGROUNDS: Goals of vestibular schwannoma (VS) microsurgery are: maximal resection, facial nerve (FN) preservation and, in selected cases, hearing preservation (HP). Postoperative HP rates are related to clinical and radiographic factors: size of tumor, preoperative hearing, hypertension, diabetes, and presence or absence of preoperative tinnitus. In this retrospective review we evaluated the influence of preoperative tinnitus on HP after VS surgery in patients with preoperative socially useful hearing (SUH)...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945051/radiologic-characteristics-of-ependymomas-a-case-based-approach
#5
David Khatami, Ekkehard M Kasper, Rafeeque Bhadelia, Rafael Rojas
The purpose of this paper is to interoduce and review the characteristic imaging features of ependymal neoplasms through a comprehensive case-based approach. Illustrated cases highlight both common and uncommon manifestations of CNS-ependymomas. The combination of imaging features, location of the tumor, and patient's demographics often allow the suggestion of ependymoma as a lead entity in the differential diagnosis. However, significant overlap exists between the radiologic characteristics of ependymomas and those of other tumors commonly encountered in the same locations, which can pose a challenge for a definitive diagnosis based on imaging alone...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945013/pro-regenerative-hydrogel-restores-scarless-skin-during-cutaneous-wound-healing
#6
Guoming Sun
The transformation of fibrotic healing process to regenerative one has great potential to fully restore wounded skin. The M2 macrophage phenotype promotes constructive tissue remodeling and instructs tissue repair in a regenerative manner. It is hypothesized that hydrogels that can establish robustness of endogenous cells to regulate M2 phenotype will promote constructive dermal remodeling. Toward this end, a series of dextran-based bioabsorbable hydrogels are developed and self-crosslinkable dextran-isocyanatoethyl methacrylate-ethylamine (DexIEME) is identified as the potential scaffold...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944998/enhanced-immune-response-induced-by-p5-her2-neu-derived-peptide-pulsed-dendritic-cells-as-a-preventive-cancer-vaccine
#7
Zahra Gholizadeh, Jalil Tavakkol-Afshari, Amin Reza Nikpoor, Seyed Amir Jalali, Mahmoud Reza Jaafari
Dendritic cells are special and powerful antigen-presenting cells that can induce primary immune responses against tumour-associated antigens. They can present antigens via both MHC-I and MHC-II, so they have the ability to stimulate both cytotoxic T lymphocytes and T helper cells. Furthermore, CD8(+) cytotoxic T lymphocytes require activation by CD4(+) T cells. This requires a CD4(+) T cell activator molecule, of which PADRE is one of the best. We chose an approach to use both of these important arms of the immune system...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944997/desire-for-parenthood-and-reproductive-health-knowledge-in-adolescents-and-young-adults-with-sickle-cell-disease-and-their-caregivers
#8
Leena Nahata, Nicole M Caltabellotta, Kyle Ball, Sarah H O'Brien, Susan E Creary
BACKGROUND/OBJECTIVE: Sickle cell disease (SCD) and hydroxyurea have implications for fertility and reproductive health. The goal of this study was to examine desire for parenthood and reproductive health knowledge among a cohort of adolescent and young adult (AYA) with SCD receiving hydroxyurea and their caregivers at a large pediatric academic center. METHODS: Patients with SCD were approached from September 2016 to July 2017 if they were: (1) 12-20 years old, (2) prescribed hydroxyurea for at least 6 months, (3) proficient in English, and (4) accompanied by a caregiver who was proficient in English and willing to participate...
September 25, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28944993/evaluation-of-prolonged-exposure-to-varenicline-in-adult-rats-hematological-biochemical-and-anatomopathological-studies
#9
Julia Zaccarelli-Magalhães, Natalia Moreira, Thaisa Meira Sandini, Gabriel Ramos de Abreu, Angélica Maria Sánchez-Sarmiento, Esther Lopes Ricci, André Rinaldi Fukushima, Helenice de Souza Spinosa
Varenicline is a synthetic chemical substance produced from the alkaloid cytisine, used for smoking treatment, which acts as a partial agonist for α4β2 and α3β4 nicotinic cholinergic receptors and as a total agonist for α7 receptor. While there are studies regarding varenicline's non-smoking-related effects, as in treatment for drug dependence, there are no studies in the literature evaluating the long-term toxicity of varenicline through a physiological approach. Thus, the aim of this study was to evaluate possible toxicity through hematological, biochemical and anatomopathological parameters of prolonged exposure (30 days) to varenicline in rats...
September 25, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28944991/a-qualitative-study-exploring-midwives-perceptions-and-knowledge-of-maternal-obesity-reflecting-on-their-experiences-of-providing-healthy-eating-and-weight-management-advice-to-pregnant-women
#10
Mary T McCann, Lisa Newson, Catriona Burden, Jane S Rooney, Margaret S Charnley, Julie C Abayomi
Midwives are responsible for providing advice regarding the complex issues of healthy eating and weight management during pregnancy. This study utilised an inductive data-driven thematic approach in order to determine midwives' perceptions, knowledge, and experiences of providing healthy eating and weight management advice to pregnant women. Semistructured interviews with 17 midwives were transcribed verbatim and data subjected to thematic analysis. The findings offer insight into the challenges facing midwives in their role trying to promote healthy eating and appropriate weight management to pregnant women...
September 25, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28944986/development-and-in-vitro-in-vivo-evaluation-of-a-novel-benznidazole-liquid-dosage-form-using-a-quality-by-design-approach
#11
Higo Fernando Santos Souza, Daniel Real, Darío Leonardi, Sandra Carla Rocha, Victoria Alonso, Esteban Serra, Ariel Mariano Silber, Claudio Javier Salomon
OBJECTIVES: To develop an alcohol-free solution suitable for children of benznidazole, the drug of choice for treatment of Chagas disease. METHODS: In a quality-by-design approach a systematic optimization procedure was carried out in order to estimate the values of the factors leading to the maximum drug concentration. The formulations were analyzed in terms of chemical and physical stability and drug content. The final preparation was subjected to an in-vivo palatability assay...
September 25, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28944983/oral-prolonged-release-oxycodone-naloxone-for-managing-pain-and-opioid-induced-constipation-a-review-of-the-evidence
#12
REVIEW
Bart J Morlion, Stefan A Mueller-Lissner, Renato Vellucci, Wojciech Leppert, Benoît C Coffin, Sara L Dickerson, Tony O'Brien
BACKGROUND: Opioids provide effective relief from moderate-to-severe pain and should be prescribed as part of a multifaceted approach to pain management when other treatments have failed. Fixed-dose oxycodone/naloxone prolonged-release tablets (OXN PR) were designed to address the opioid class effect of opioid-induced constipation (OIC) by combining the analgesic efficacy of oxycodone with the opioid receptor antagonist, naloxone, which has negligible systemic availability when administered orally...
September 25, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28944966/inpatient-management-of-children-with-recessive-dystrophic-epidermolysis-bullosa-a-review
#13
REVIEW
Alvin W Li, Brea Prindaville, Scot T Bateman, Timothy E Gibson, Karen Wiss
Recessive dystrophic epidermolysis bullosa is a disorder marked by skin and mucosal blistering after minimal trauma. Even the most routine procedures in the hospital, if done incorrectly, can precipitate extensive skin loss, pain, and scarring. Most providers have little experience working with patients with this degree of skin fragility. When a person with recessive dystrophic epidermolysis bullosa is admitted to the hospital, there are multiple considerations to keep in mind while strategizing an effective care plan: avoidance of new blisters with a "hands-off" approach; careful consideration of all indwelling devices; symptomatic management of pain, itch, and anxiety; coordination of dressing changes; aggressive treatment of skin infections; environmental and staffing considerations; and awareness of other chronic complications that affect care, such as anemia, malnutrition, and chronic pain...
September 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28944965/comparison-of-psoriasis-and-atopic-dermatitis-guidelines-an-argument-for-aggressive-atopic-dermatitis-management
#14
Mary E Lohman, Peter A Lio
The development of effective systemic treatments has revolutionized the treatment of inflammatory skin diseases. The availability of safe new treatments and the understanding of psoriasis as a systemic disease with comorbidities and effects on quality of life have driven the current aggressive treatment paradigm of psoriasis. Historically the morbidity of atopic dermatitis (AD) has been dismissed, given the perception of AD as "just" a rash. Differences in the guidelines for psoriasis and AD management may suggest variations in the current conceptualization of disease severity and effects on quality of life...
September 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28944961/two-case-studies-on-how-study-designs-can-be-made-more-informative-using-modeling-and-simulation-approaches
#15
Philip J Lowe, Martin Fink, Mark N Milton
Drug development should extract maximum information from experiments with minimized exposure of patients or experimental animals to invasive procedures and potentially harmful effects with minimized investment of time and money. Herein, two aspects of study design are explored illustrating how information can be extracted more efficiently by investigating a range of exposures within each individual by either following responses as drug concentrations decline or by within-individual dose escalation, rather than relying on steady-state cross-sectional analyses...
September 25, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28944927/%C3%AE-7-nicotinic-acetylcholine-receptor-agonist-attenuates-the-cerebral-injury-in-a-rat-model-of-cardiopulmonary-bypass-by-activating-the-akt-gsk3%C3%AE-pathway
#16
Yingjie Sun, Dandan Song, Mei Wang, Keyan Chen, Tiezheng Zhang
α7 nicotinic acetylcholine receptor (α7nAchR) agonist treatment may provide a promising therapeutic effect for cerebral injuries. However, it is unclear whether the activation of α7nAchR agonist may reduce cerebral injuries induced by cardiopulmonary bypass (CPB). A total of 96 male Sprague‑Dawley rats were randomly divided into four groups (n=24/group): i) Sham operation group; ii) CPB group; iii) CPB + α7nAchR agonist group; and iv) CPB + α7nAchR agonist + α7nAchR antagonist group. Following treatment, 24 rats from each group were sacrificed and the serum and hippocampal tissues were collected...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944852/use-of-immunoproteomics-to-identify-immunogenic-proteins-in-a-rat-model-of-acute-respiratory-distress-syndrome
#17
Zongshu Ji, Haiyan Liu, Linsen Fang, Youxin Yu, Zheng Zhou
Acute respiratory distress syndrome (ARDS) is a common and life‑threatening clinical syndrome, and seeking biomarkers of ARDS has been an area of continuing research. The present study hypothesized that alterations to certain immunogenic substances occur in injured lungs and are able to specifically bind with corresponding proteins in the blood, and that these proteins may be readily detected. To investigate this hypothesis, a rat model of ARDS was established by cecal ligation and puncture surgery, and an immunoproteomics approach, using serum as the primary antibody in a western blot analysis, was used with the aim of identifying immunogenic proteins in the injured lungs...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944846/hedyotis-diffusa-willd-suppresses-metastasis-in-5%C3%A2-fluorouracil%C3%A2-resistant-colorectal-cancer-cells-by-regulating-the-tgf%C3%A2-%C3%AE-signaling-pathway
#18
Zijun Lai, Zhaokun Yan, Wujin Chen, Jun Peng, Jianyu Feng, Qiongyu Li, Yiyi Jin, Jiumao Lin
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract, and threatens the survival and health of patients with CRC. Chemotherapy remains one of the main therapeutic approaches for patients with CRC; however, drug resistance limits the long‑term use. CRC cells with multi‑drug resistance (MDR) exhibit increased survival times and metastatic potential, which may lead to the recurrence and metastasis of CRC. In addition, MDR is one of the major causes of chemotherapy failure in clinical treatment...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944829/thymic-function-in-the-regulation-of-t-cells-and-molecular-mechanisms-underlying-the-modulation-of-cytokines-and-stress-signaling-review
#19
Fenggen Yan, Xiumei Mo, Junfeng Liu, Siqi Ye, Xing Zeng, Dacan Chen
The thymus is critical in establishing and maintaining the appropriate microenvironment for promoting the development and selection of T cells. The function and structure of the thymus gland has been extensively studied, particularly as the thymus serves an important physiological role in the lymphatic system. Numerous studies have investigated the morphological features of thymic involution. Recently, research attention has increasingly been focused on thymic proteins as targets for drug intervention. Omics approaches have yielded novel insights into the thymus and possible drug targets...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944820/identification-of-14%C3%A2-3%C3%A2-3%C3%AE-as-a-potential-biomarker-in-gastric-cancer-by-proteomics%C3%A2-based-analysis
#20
Xin-Xin Liu, Hua Ye, Peng Wang, Yi Zhang, Jian-Ying Zhang
The identification of tumor biomarkers to support early diagnosis and tumor progression monitoring may potentially reduce the mortality of gastric cancer (GC). The present study aimed to detect novel tumor‑associated antigens from the AGS GC cell line, and to identify their associated autoantibodies in sera from patients with GC by proteomics‑based approaches. Proteins from AGS cell lysates were isolated using two‑dimensional polyacrylamide gel electrophoresis, and western blotting was subsequently performed, to determine autoantibody responses in sera derived from patients with GC and healthy individuals...
September 18, 2017: Molecular Medicine Reports
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