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Johannes Fahrmann, Dmitry Grapov, Jun Yang, Bruce Hammock, Oliver Fiehn, Graeme I Bell, Manami Hara
Nonobese diabetic (NOD) mice are a commonly used model of type 1 diabetes (T1D). However, not all animals will develop overt diabetes despite undergoing similar autoimmune insult. In this study, a comprehensive metabolomic approach, consisting of gas chromatography time-of-flight (GC-TOF) mass spectrometry (MS), ultra-high-performance liquid chromatography-accurate mass quadruple time-of-flight (UHPLC-qTOF) MS and targeted UHPLC-tandem mass spectrometry-based methodologies, was used to capture metabolic alterations in the metabolome and lipidome of plasma from NOD mice progressing or not progressing to T1D...
June 1, 2015: American Journal of Physiology. Endocrinology and Metabolism
Hee Sun Kim, Su Jung Baik, Kyung Hee Kim, Cho Rong Oh, Sang In Lee
BACKGROUND/AIMS: Current international guidelines recommend colorectal cancer screening for average-risk people over 50 years of age. Accordingly, we aimed to estimate the prevalence of colorectal neoplasms in all age groups and evaluate associated risk factors. METHODS: Data of 14,932 subjects who underwent colonoscopy from July 2006 to January 2012 at Health Promotion Center, Gangnam Severance Hospital (Seoul, Korea) as part of a health check-up were reviewed retrospectively...
August 25, 2013: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Angela Marzocchetti, Jessica Schwarz, Simona Di Giambenedetto, Manuela Colafigli, Laura Bracciale, Massimilliano Fabbiani, Massimo Fantoni, Enrico Trecarichi, Roberto Cauda, Andrea De Luca
We investigated whether polymorphisms in human candidate genes could be associated with a different risk of developing lipodystrophy and dyslipidemia in HIV-infected patients starting combination antiretroviral therapy (cART). Genomic DNA samples from white HIV-1-infected patients were analyzed for seven polymorphisms located in the MDR1, TNF-╬▒, APM1, APOE, and LPL genes. Lipid data were retrospectively collected beginning with the initiation of cART. Lipodystrophy was assessed cross-sectionally and then prospectively...
December 2011: AIDS Research and Human Retroviruses
Ramaswamy Govindan, John Crowley, Lee Schwartzberg, Peter Kennedy, Charles Williams, Bradley Ekstrand, Alan Sandler, Dinah Jaunakais, Vanessa Bolejack, Richard Ghalie
PURPOSE: To evaluate the effect of bexarotene on survival in patients with relapsed non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Patients with stage IIIB NSCLC with pleural effusion or stage IV NSCLC, who had Eastern Cooperative Oncology Group performance status 0 to 2, and were previously treated with > or = two different regimens that must have included a platinum and a taxane, received oral bexarotene 400 mg/m2/d plus concomitant levothyroxine and a lipid-lowering agent...
October 20, 2006: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
H Z W Grotto, J F A Noronha
We have described preliminary results of platelet larger cell ratio (P-LCR) analysis, provided by an automated hematology analyzer in patients with hypercholesterolemia and/or hypertriglyceremia. P-LCR values were significantly higher in patients (n = 41) than in control normal group (n = 20) (P < 0.0001). Larger platelets are more reactive and contribute to vasooclusive events in patients with dyslipidemia. P-LCR may be used as an indicator of risk factor for thromboembolic ischemic events.
October 2004: Clinical and Laboratory Haematology
R A Muzzarelli
After providing basic information on enzymes involved in cholesterol homeostasis, and on management of hypertriglyceremia and hypercholesterolemia, with the aid of cholestyramine and fibric acid, this chapter examines the effects of the ingestion of chitosan. Dietary chitosan is effective on serum cholesterol and in atherosclerosis in normal and diabetic mice, and lends itself to the treatment of hypercholesterolemia in humans. It also exhibits antiulcer, antiarthritic, antihypertension and antiuricemic properties...
1999: EXS
W al-Eid, A al-Jefri, S Bahabri, S al-Mayouf
A 6-year-old boy developed hemophagocytic syndrome during the recurrent course of Kawasaki disease. Despite the appropriate treatment modalities for Kawasaki disease, he developed pancytopenia, marked hepatosplenomegaly, high-grade fever, hyperferritinemia, hypertriglyceremia, and evidence of hemophagocytosis in the liver biopsy. Although the course was stormy, he responded well to a combination therapy of corticosteroids, etoposide VP16, and granulocyte colony-stimulating factor G-CSF. The clinical course and the treatment given were compared with the previous reported cases...
June 2000: Pediatric Hematology and Oncology
G Broughton
Chenodeoxycholate (3 alpha, 7 alpha-dihydroxy-5 beta-cholanic acid) is a primary bile acid directly synthesized from cholesterol. It is an amphipathic molecule, possessing both a hydrophobic side and a polar hydrophilic side, giving it the ability to solubilize lipids in a water environment. Bile acids are necessary for the absorption of fats and fat soluble vitamins. Chenodeoxycholate inhibits the rate-limiting step of cholesterol synthesis, the formation of hydroxymethyl-glutaryl-coenzyme A. It was first reported to be useful in the dissolution of cholesterol gallstones in 1972...
January 1994: American Journal of the Medical Sciences
Y Sado, T Okigaki, H Takamiya, S Seno
Experimental autoimmune glomerulonephritis with pulmonary hemorrhage was induced in rats by a single injection of soluble antigen obtained from bovine glomerular basement membrane. Groups of rats were injected with various amounts of the nephritogenic antigen with Freund's complete adjuvant and killed 10 weeks later. Glomerulonephritis with linear deposition of IgG along the glomerular basement membrane developed in 7 of 10 rats injected with 10 micrograms of the antigen and all 20 rats of other 2 groups with 100 or 1,000 micrograms of the antigen...
December 1984: Journal of Clinical & Laboratory Immunology
F Dairou, C Ciancioni, J L de Gennes
No abstract text is available yet for this article.
March 1978: Annales de M├ędecine Interne
W Lutz
No abstract text is available yet for this article.
June 21, 1976: Polski Tygodnik Lekarski
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