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https://www.readbyqxmd.com/read/28203487/peroxisome-proliferator-activated-receptor-%C3%AE-agonists-potential-therapeutics-for-neuropathology-associated-with-fetal-alcohol-spectrum-disorders
#1
Paul D Drew, Cynthia J M Kane
Fetal alcohol spectrum disorders (FASD) result from fetal exposure to alcohol during pregnancy. These disorders present a variety of sequelae including involvement of the central nervous system (CNS) with lasting impact on cognitive function and behavior. FASD occur at an alarming rate and have significant personal and societal impact. There are currently no effective treatments for FASD. Recent studies demonstrate that ethanol induces potent neuroinflammation in many regions of the developing brain. Furthermore, anti-inflammatory agents such as peroxisome proliferator-activated receptor (PPAR)-γ agonists suppress ethanol-induced neuroinflammation and neurodegeneration...
December 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/28199918/factors-associated-with-alcohol-use-prior-to-and-during-pregnancy-among-hiv-infected-pregnant-women-in-cape-town-south-africa
#2
Kirsty Brittain, Robert H Remien, Tamsin Phillips, Allison Zerbe, Elaine J Abrams, Landon Myer, Claude A Mellins
INTRODUCTION: Alcohol use during pregnancy is prevalent in South Africa, but there are few prospectively-collected data exploring patterns of consumption among HIV-infected women, which may be important to improve maternal and child health outcomes. We examined patterns of and factors associated with alcohol use prior to and during pregnancy among HIV-infected pregnant women in Cape Town, South Africa. METHODS: Participants were enrolled when entering antenatal care at a large primary care clinic, and alcohol use was assessed using the AUDIT (Alcohol Use Disorders Identification Test)...
January 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28191917/newborn-birth-weight-of-pregnant-women-on-methadone-or-buprenorphine-maintenance-treatment-a-national-contingency-management-approach-trial
#3
Einat Peles, Anat Sason, Shaul Schreiber, Miriam Adelson
BACKGROUND AND OBJECTIVES: Methadone maintenance treatment (MMT) is the gold standard for pregnant women with opioid use disorders. Still, low birth-weights were reported, in particular of mothers who became pregnant before admission to MMT. We studied whether an escalating incentive contingency-management approach may contribute to better newborn birth-weights. METHODS: A nationwide controlled randomized trial among all Israeli methadone/buprenorphine maintenance treatment (MBMT), newly or already in treatment pregnant women was performed...
February 13, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28187518/male-caffeine-and-alcohol-intake-in-relation-to-semen-parameters-and-in%C3%A2-vitro-fertilization-outcomes-among-fertility-patients
#4
A E Karmon, T L Toth, Y-H Chiu, A J Gaskins, C Tanrikut, D L Wright, R Hauser, J E Chavarro
Much of the literature on the impact of male caffeine and alcohol intake on reproductive outcomes has utilized semen quality as a proxy for male fertility, although semen parameters have a limited predictive value for spontaneous pregnancy. The objective of this study was to investigate whether male caffeine and alcohol intakes are associated with semen parameters and assisted reproductive technology outcome. The Environment and Reproductive Health Study, an ongoing prospective cohort study, enrolls subfertile couples presenting for treatment at an academic fertility center (2007-2012)...
February 10, 2017: Andrology
https://www.readbyqxmd.com/read/28181676/risks-of-preterm-delivery-and-small-for-gestational-age-infants-effects-of-nondaily-and-low-intensity-daily-smoking-during-pregnancy
#5
Van T Tong, Lucinda J England, Karilynn M Rockhill, Denise V D'Angelo
BACKGROUND: Few studies have examined the effects of nondaily smoking or low-intensity daily smoking and infant outcomes. We examined the associations between preterm delivery and small for gestational age (SGA) infants in relation to both nondaily and daily smoking. METHODS: We used population-based data on women who delivered live singleton infants using the 2009-11 Pregnancy Risk Assessment Monitoring System. Women's smoking status in the last 3 months of pregnancy was categorised as nonsmokers, quitters, nondaily smokers (<1 cigarette/day), and daily smokers...
February 9, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28174149/smartmom-text-messaging-for-prenatal-education-a-qualitative-focus-group-study-to-explore-canadian-women-s-perceptions
#6
Sarah Munro, Amber Hui, Vanessa Salmons, Carolyn Solomon, Emily Gemmell, Nahal Torabi, Patricia A Janssen
BACKGROUND: We engaged Canadian women in the development of a prenatal education program delivered via one-way text messaging called SmartMom. SmartMom is the first peer-reviewed, evidence-based mHealth program for prenatal education in Canada and the first to be endorsed by the Society of Obstetricians and Gynaecologists of Canada. OBJECTIVE: To explore women's preferences for a prenatal education program by text messaging. METHODS: We conducted a qualitative focus group study in three Canadian communities in the Northern Health Authority...
February 7, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28173632/impact-of-the-choices-intervention-in-preventing-alcohol-exposed-pregnancies-in-american-indian-women
#7
Jessica D Hanson, Morgan E Nelson, Jamie L Jensen, Amy Willman, Jacque Jacobs-Knight, Karen Ingersoll
BACKGROUND: Fetal Alcohol Spectrum Disorders (FASD) comprise a continuum of lifelong outcomes in those born prenatally exposed to alcohol. Although studies have shown no differences in rates by race, FASD is of particular concern for American Indian communities. One tribally-run prevention program is the Oglala Sioux Tribe (OST) CHOICES Program, which is modeled after the evidence-based CHOICES program that was focused on preconceptional prevention of alcohol-exposed pregnancy (AEP) by reducing risky drinking in women at-risk for pregnancy and/or preventing unintended pregnancy...
February 7, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28169608/vitamin-d-deficiency-in-pregnant-ukrainian-women-effects-of-alcohol-consumption-on-vitamin-d-status
#8
Charles R Carlson, Janet Y Uriu-Adams, Christina D Chambers, Lyubov Yevtushok, Natalya Zymak-Zakutnya, Priscilla H Chan, Jordan J Schafer, Wladimir Wertelecki, Carl L Keen
OBJECTIVE: Heavy alcohol consumption can alter vitamin D status; however, the relationships between alcohol consumption and vitamin D concentrations in pregnant women have not been well studied. The aim of this study was to investigate the vitamin D status in a population of alcohol-exposed (N = 180) and low/unexposed control (N = 179) Ukrainian pregnant women. METHODS: Women who attended prenatal care facilities in 2 regions of Ukraine (Rivne and Khmelnytsky) for a routine prenatal visit were screened for the study...
January 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28168434/fetal-alcohol-spectrum-disorders-characteristics-complications-and-treatment
#9
Lauren F Wilhoit, David A Scott, Brooke A Simecka
Fetal Alcohol Spectrum Disorders (FASD) includes a continuum of disorders that occur in children as a result of their mothers' consumption of alcohol during pregnancy. The most severe of these disorders is Fetal Alcohol Syndrome (FAS). FASD presents differently in every child, but all children with FASD have intellectual and/or behavioral impairments. There is no cure for FASD, but research shows that early intervention and life-long support help those born with FASD to manage the difficulties that come with it...
February 6, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28161688/exploring-health-education-with-midwives-as-perceived-by-pregnant-women-in-primary-care-a-qualitative-study-in-the-netherlands
#10
Ruth Baron, Querine Heesterbeek, Judith Manniën, Eileen K Hutton, Johannes Brug, Marjan J Westerman
OBJECTIVE: to explore the experiences, wishes and needs of pregnant women with respect to health education in primary care with midwives. DESIGN: qualitative semi-structured interview study, using thematic analysis and constant comparison. SETTING AND PARTICIPANTS: twenty-two pregnant women in midwife-led primary care, varying in socio-demographic characteristics, weeks of pregnancy and region of residence in the Netherlands, were interviewed between April and December 2013...
January 21, 2017: Midwifery
https://www.readbyqxmd.com/read/28160250/thiopurines-and-methotrexate-use-in-ibd-patients-in-a-biologic-era
#11
REVIEW
Gerassimos J Mantzaris
Although we have been living in the era of biologic therapy for several decades, the use of immunomodulators (primarily thiopurines [azathioprine and mercaptopurine] and less so methotrexate) still remains an important component of the inflammatory bowel disease (IBD) pharmaceutical arsenal. Thiopurines as monotherapy exert corticosteroid-sparing effects and can maintain long-term remission in a considerable proportion of patients who have frequent relapses and are or have become mesalazine and/or corticosteroid intolerant or refractory...
February 3, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28156197/risk-factors-for-perinatal-mortality-in-murmansk-county-russia-a-registry-based-study
#12
Anna A Usynina, Andrej M Grjibovski, Alexandra Krettek, Jon Øyvind Odland, Alexander V Kudryavtsev, Erik Eik Anda
BACKGROUND: Factors contributing to perinatal mortality (PM) in Northwest Russia remain unclear. This study investigated possible associations between selected maternal and fetal characteristics and PM based on data from the population-based Murmansk County Birth Registry. OBJECTIVE: This study investigated possible associations between selected maternal and fetal characteristics and PM based on data from the population-based Murmansk County Birth Registry. METHODS: The study population consisted of all live- and stillbirths registered in the Murmansk County Birth Registry during 2006-2011 (n = 52,806)...
2017: Global Health Action
https://www.readbyqxmd.com/read/28155317/the-pattern-and-correlates-of-intimate-partner-violence-among-women-in-kano-nigeria
#13
Tanko S Tanimu, Stephen Yohanna, Suleiman Y Omeiza
BACKGROUND: Intimate partner violence (IPV) has been increasingly recognised as a major public health and human rights problem that cuts across all populations, irrespective of social, economic, religious or cultural groups. OBJECTIVES: The objectives of this study were to determine the prevalence, pattern and correlates of IPV among women attending the General Out Patient Clinic of Aminu Kano Teaching Hospital, Kano, Nigeria. It was also designed to determine the pattern of health complications associated with IPV as well as the perception of women on intimate partner violence...
November 29, 2016: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28153658/first-trimester-alcohol-exposure-alters-placental-perfusion-and-fetal-oxygen-availability-affecting-fetal-growth-and-development-in-a-non-human-primate-model
#14
Jamie O Lo, Matthias C Schabel, Victoria H J Roberts, Xiaojie Wang, Katherine S Lewandowski, Kathleen A Grant, Antonio E Frias, Christopher D Kroenke
BACKGROUND: Prenatal alcohol exposure leads to impaired fetal growth, brain development, and stillbirth. Placental impairment likely contributes to these adverse outcomes, but the mechanisms and specific vasoactive effects of alcohol that links altered placental function to impaired fetal development remain areas of active research. OBJECTIVE: Recently, we developed magnetic resonance imaging techniques in nonhuman primates to characterize placental blood oxygenation through measurements of T2* and perfusion using dynamic contrast-enhanced magnetic resonance imaging...
January 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28150815/gestational-weight-gain-and-fetal-maternal-adiponectin-leptin-and-crp-results-of-two-birth-cohorts-studies
#15
Chad A Logan, Rebecca Bornemann, Wolfgang Koenig, Frank Reister, Viola Walter, Giamila Fantuzzi, Maria Weyermann, Hermann Brenner, Jon Genuneit, Dietrich Rothenbacher
Gestational weight gain (GWG) is an important modifiable factor known to influence fetal outcomes including birth weight and adiposity. Unlike behaviors such as smoking and alcohol consumption, the effect of GWG throughout pregnancy on fetal development and other outcomes has not been extensively studied. The aim of this study was to investigate the relationship of GWG with endocrine factors such as adiponectin, leptin, and C-reactive protein which may be associated with inflammatory response, fetal growth, and adiposity later in life...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28134474/risk-of-cerebral-palsy-in-chinese-children-a-n-m-matched-case-control-study
#16
Jing Gao, Bin Zhao, Luna He, Meiling Sun, Xuefeng Yu, Lina Wang
AIM: To estimate epidemiological risk factors for cerebral palsy (CP) in children. METHODS: A N:M matched case control study was conducted in 114 persons with CP and 1286 controls. Relevant data were collected using a maternal self-design questionnaire. Univariate logistic regression and multivariate conditional logistic regression analyses were performed using SPSS. RESULTS: Univariate analysis has yielded 20 significant risk factors for CP...
January 30, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28133896/efficacy-comparison-of-transcatheter-arterial-embolization-with-gelatin-sponge-and-polyvinyl-alcohol-particles-for-the-management-of-cesarean-scar-pregnancy-and-follow-up-study
#17
Yan Ma, Chao Yang, Xiaonan Shao
AIM: The aim of this study was to compare the therapeutic efficacy of transcatheter arterial embolization (TAE) with gelatin sponge (GS) and polyvinyl alcohol (PVA) particles for cesarean scar pregnancy (CSP). METHODS: A total of 35 patients with CSP, who were classified into either the GS group (n = 22) or the PVA group (n = 13), underwent TAE and postoperative ultrasound-guided curettage. Their hospital stay, first-scheme success rate, intra-curettage blood loss, serum β-human chorionic gonadotropin (hCG) level, and other indicators were simultaneously recorded...
January 30, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28130996/association-of-maternal-and-index-child-s-diet-with-subsequent-leukemia-risk-a-systematic-review-and-meta-analysis
#18
REVIEW
Nick Dessypris, Maria A Karalexi, Evangelos Ntouvelis, Andreas-Antonios Diamantaras, Vassilios Papadakis, Margarita Baka, Emmanuel Hatzipantelis, Maria Kourti, Maria Moschovi, Sophia Polychronopoulou, Vasiliki Sidi, Eftichia Stiakaki, Eleni Th Petridou
BACKGROUND: Exploring the effect of maternal and/or childhood diet on offspring leukemogenesis is challenging, given differences in food group categories, their potentially variable impact depending on time window of exposure and the multiple leukemia subtypes. We opted to quantitatively synthesize published data on the association of maternal/child diet with leukemia risk. METHODS: Medline was searched until June 30th, 2016 for eligible articles on the association of childhood leukemia with consumption of (i) food groups, excluding alcoholic and non-alcoholic beverages, and (ii) specific dietary supplements before/during index pregnancy and childhood...
January 25, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28128508/the-influence-of-age-at-menarche-menstrual-cycle-length-and-bleeding-duration-on-time-to-pregnancy-a-large-prospective-cohort-study-among-rural-chinese-women
#19
Q Zhang, Y Y Wang, Y Zhang, H G Zhang, Y Yang, Y He, J H Xu, J Zhao, Z Q Peng, X Ma
OBJECTIVE: To investigate the relations among age at menarche (AAM), menstrual cycle length, menstrual bleeding duration and time to pregnancy in a large cohort of rural Chinese women. DESIGN: A prospective cohort study. SETTING: Local family-planning service agencies and maternal/child care service centres. POPULATION: A total of 391 320 rural women of reproductive age who participated in the National Free Pre-pregnancy Checkups and were planning to conceive were enrolled...
January 27, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28127873/early-menarche-and-risk-taking-behavior-in-korean-adolescent-students
#20
Hyun Soo Kim, Byeong Moo Choe, Jae Hong Park, Seong Hwan Kim
INTRODUCTION: The aim of this study is to assess the correlation between early menarche and risk-taking behavior in a representative sample of Korean adolescent students. METHODS: Data were drawn from a cross-sectional, nationally representative sample of 33 829 female adolescents (grades 7-12) from the 2014 Korean Youth Risk Behavior Web-based Survey. Logistic regression analysis was conducted to test the association between early menarche and risk-taking behavior...
January 27, 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
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