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https://www.readbyqxmd.com/read/28919490/alcohol-exposure-induces-chick-craniofacial-bone-defects-by-negatively-affecting-cranial-neural-crest-development
#1
Ping Zhang, Guang Wang, Zhuangling Lin, Yushi Wu, Jing Zhang, Meng Liu, Kenneth Ka Ho Lee, Manli Chuai, Xuesong Yang
Excess alcohol consumption during pregnancy could lead to fetal alcohol syndrome (FAS). However, the molecular mechanism leading to craniofacial abnormality, a feature of FAS, is still poorly understood. The cranial neural crest cells (NCCs) contribute to the formation of the craniofacial bones. Therefore, NCCs exposed to ethanol was investigated - using chick embryos and in vitro explant culture as experimental models. We demonstrated that exposure to 2% ethanol induced craniofacial defects, which includes parietal defect, in the developing chick fetus...
September 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28915868/the-cedar-project-using-indigenous-specific-determinants-of-health-to-predict-substance-use-among-young-pregnant-involved-aboriginal-women
#2
Sana Z Shahram, Joan L Bottorff, Nelly D Oelke, Leanne Dahlgren, Victoria Thomas, Patricia M Spittal
BACKGROUND: Indigenous women in Canada have been hyper-visible in research, policy and intervention related to substance use during pregnancy; however, little is known about how the social determinants of health and substance use prior to, during, and after pregnancy intersect. The objectives of this study were to describe the social contexts of pregnant-involved young Indigenous women who use substances and to explore if an Indigenous-Specific Determinants of Health Model can predict substance use among this population...
September 15, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28915802/determinants-of-pre-eclampsia-eclampsia-among-women-attending-delivery-services-in-selected-public-hospitals-of-addis-ababa-ethiopia-a-case-control-study
#3
Teklit Grum, Abiy Seifu, Mebrahtu Abay, Teklit Angesom, Lidiya Tsegay
BACKGROUND: Pre-eclampsia is a pregnancy-specific hypertensive disorder usually occurs after 20 weeks of gestation. It is one of the leading causes of maternal and perinatal morbidity and mortality worldwide. In Ethiopia, the major direct obstetric complications including pre-eclampsia/eclampsia account for 85% of the maternal deaths. Unlike deaths due to other direct causes, pre-eclampsia/ eclampsia related deaths appear to be increasing and linked to multiple factors, making prevention of the disease a continuous challenge...
September 15, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28915355/thiamin-deficiency-on-fetal-brain-development-with-and-without-prenatal-alcohol-exposure
#4
Olena Kloss, Michael Eskin, Miyoung Suh
Adequate thiamin levels are crucial for optimal health, through maintenance of homeostasis and viability of metabolic enzymes, which require thiamine as a co-factor. Thiamin deficiency occurs during pregnancy when dietary intake is inadequate or excessive alcohol is consumed. Thiamin deficiency leads to brain dysfunction due to its involvement in synthesis of myelin and neurotransmitters (eg. acetylcholine, γ-aminobutyric acid, glutamate), and increases oxidative stress by decreasing the production of reducing agents...
September 15, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28904500/retrospective-study-of-factors-affecting-intrauterine-insemination-pregnancy-outcome-the-impact-of-male-habits-and-working-environment
#5
Matheswari Govindarajan, Shanmugapriya Mallikarjunan, Hajira S R Ahmed, Naveena Lakshmanan, D Silambuchelvi, M Sujatha, Vidyalakshmi Subramanian
AIMS: This study is aimed at determining the prognostic factors influencing successful pregnancy following intrauterine insemination (IUI). SETTINGS AND DESIGN: Retrospective analysis. MATERIALS AND METHODS: A total of 2123 cycles undergone by 871 couples during the period of 5 years (2011-2015) were retrospectively studied. STATISTICAL ANALYSIS USED: Each of the factors was compared with pregnancy outcome (PO) using statistical analysis with a confidence interval of 95% in SPSS software version 19...
April 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28898707/the-effect-of-prenatal-substance-use-and-maternal-contingent-responsiveness-on-infant-affect
#6
Jean Lowe, Fares Qeadan, Lawrence Leeman, Shikhar Shrestha, Julia M Stephen, Ludmila N Bakhireva
BACKGROUND: The effects of prenatal substance exposure on neurobehavioral outcomes are inherently confounded by the effects of the postnatal environment, making it difficult to disentangle their influence. The goal of this study was to examine the contributing effects of prenatal substance use and parenting style (operationalized as contingent responding during the play episodes of the Still-face paradigm [SFP]) on infant affect. METHODS: A prospective cohort design was utilized with repeated assessment of substance use during pregnancy and the administration of the SFP, which measures infant response to a social stressor, at approximately 6months of age...
September 9, 2017: Early Human Development
https://www.readbyqxmd.com/read/28895680/optimising-preconception-health-in-women-of-reproductive-age
#7
Adina Y Lang, Jacqueline A Boyle, Grace Fitzgerald, Helena Teede, Danielle Mazza, Lisa J Moran, Cheryce Harrison
There is a growing realisation that efforts to optimise the health of women and reduce the risk of adverse maternal, perinatal and neonatal outcomes during pregnancy should commence in the preconception period. The preconception period (prior to or between pregnancies) provides an opportune time to address reproductive intentions and promote and support wellbeing and healthy behaviour change regardless of pregnancy intention. Research over the last 30 years has explored the influence of a range of preconception risk factors and determinants of health on pregnancy and maternal and neonatal outcomes including: pregnancy planning, diet and micronutrient supplementation, physical activity, weight, smoking, recreational drug and alcohol use, mental health, oral hygiene, and chronic health and medical conditions...
September 12, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28892122/effects-of-prenatal-alcohol-consumption-on-cognitive-development-and-adhd-related-behaviour-in-primary-school-age-a-multilevel-study-based-on-meconium-ethyl-glucuronide
#8
Anna Eichler, Linda Hudler, Juliane Grunitz, Jennifer Grimm, Eva Raabe, Tamme W Goecke, Peter A Fasching, Matthias W Beckmann, Oliver Kratz, Gunther H Moll, Johannes Kornhuber, Hartmut Heinrich
BACKGROUND: Alcohol intake during pregnancy is considered to be a risk factor for child development. Child biomarkers of intrauterine alcohol exposure have been rarely studied. We investigated whether a meconium alcohol metabolite (ethyl glucuronide, EtG) was associated with cognitive development, ADHD-related behaviour and neurophysiological markers of attention and executive control of children at primary-school age. METHODS: Mothers provided self-report on prenatal alcohol consumption during their 3rd trimester...
September 11, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28890772/knowledge-and-cultural-beliefs-of-mothers-regarding-the-risk-factors-of-infant-hearing-loss-and-awareness-of-audiology-services
#9
Samantha M Govender, Nasim Banu Khan
The aim of the paper is to describe the knowledge of mothers in Durban, South Africa, regarding risk factors of hearing loss in infants and their awareness of audiology services, and to describe their cultural beliefs about the risk factors for hearing loss in infants. A descriptive survey design with quantitative methods of analysis were used. Conveniently sampled mothers (n=102) receiving postnatal care for their infants from eight provincial clinics within Durban consented to participate, yielding a response rate of 48%...
June 23, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28888041/supplementation-with-the-methyl-donor-betaine-prevents-congenital-defects-induced-by-prenatal-alcohol-exposure
#10
Ganga Karunamuni, Megan M Sheehan, Yong Qiu Doughman, Shi Gu, Jiayang Sun, Youjun Li, James P Strainic, Andrew M Rollins, Michael W Jenkins, Michiko Watanabe
BACKGROUND: Despite decades of public education about dire consequences of prenatal alcohol exposure, drinking alcohol during pregnancy remains prevalent. As high as 40% of live-born infants exposed to alcohol during gestation and diagnosed with Fetal Alcohol Syndrome have congenital heart defects that can be life-threatening. In animal models, the methyl donor betaine, found in foods such as wheat bran, quinoa, beets and spinach, ameliorated neurobehavioral deficits associated with prenatal alcohol exposure (PAE) but effects on heart development are unknown...
September 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28886465/the-interaction-of-pregnancy-substance-use-and-mental-illness-on-birthing-outcomes-in-australia
#11
Lin Zhao, Kay McCauley, Leanne Sheeran
BACKGROUND: this study aimed to (1) assess the prevalence, and demographic features of women with a history of mental illness during pregnancy and childbirth, (2) investigate maternal and perinatal outcomes in relation to mental illness and substance use, and (3) determine the effects of maternal characteristics, history of mental illness and substance use on birth outcomes. METHODS: the records of 22,193 pregnant women who gave birth at one tertiary level health service comprising three maternity settings in Victoria, Australia from 2009 to 2011 were reviewed...
November 2017: Midwifery
https://www.readbyqxmd.com/read/28884629/maternal-lifestyle-impairs-embryonic-growth-the-rotterdam-periconception-cohort
#12
Matthijs R Van Dijk, Nicole V Borggreven, Sten P Willemsen, Anton H J Koning, Régine P M Steegers-Theunissen, Maria P H Koster
Previously, embryonic growth has been assumed to be uniform, but in recent years, it has become more clear that genetic and environmental factors may influence the intrauterine environment and therefore embryonic growth trajectories as well as pregnancy course and outcome. The objective of this study was to investigate associations between modifiable maternal nutrition and lifestyle factors during the periconception period and embryonic growth. We established a prospective cohort including 342 women less than 13 weeks pregnant...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28884375/patterns-of-alcohol-intake-of-pregnant-and-lactating-women-in-rural-western-australia
#13
Elizabeth Tearne, Kylee Cox, Roslyn Giglia
Objectives Monitoring surveys and research outline a paucity of alcohol consumption data for women in the period of lactation, particularly in rural areas of developed countries. Identifying the drinking profile of ante- and postnatal women in this population will aid in the effective dissemination of public health interventions. This paper will present the first alcohol consumption data of pregnant and breastfeeding women living in rural Western Australia (WA). Methods A prospective cohort of 489 mothers and their infants were recruited between April 2010 and November 2011...
September 7, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28881390/prenatal-alcohol-exposure-in-relation-to-autism-spectrum-disorder-findings-from-the-study-to-explore-early-development-seed
#14
Alison B Singer, Arthur S Aylsworth, Christina Cordero, Lisa A Croen, Carolyn DiGuiseppi, M Daniele Fallin, Amy H Herring, Stephen R Hooper, Rebecca E Pretzel, Laura A Schieve, Gayle C Windham, Julie L Daniels
BACKGROUND: Prenatal alcohol exposure can affect neurodevelopment, but few studies have examined associations with autism spectrum disorder (ASD). METHODS: We assessed the association between maternal alcohol use and ASD in the Study to Explore Early Development, a multi-site case-control study of children born between September 2003 and August 2006 in the US Regression analyses included 684 children with research clinician-confirmed ASD, 869 children with non-ASD developmental delays or disorders (DDs), and 962 controls ascertained from the general population (POP)...
September 7, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28875976/-atopic-dermatitis-risk-factors-and-treatment
#15
REVIEW
Martyna Zaleska, Ewelina Trojacka, Stepan Savitskyi, Agnieszka Terlikowska-Brzósko, Ryszard Galus
Atopic dermatitis (AD) is a chronic, inflammatory skin disease characterized by severe itching and eczematic skin lesions. In Poland from 1.5 to 2.5 million people suffer from AD. The pathophysiologic complexity and the wide spectrum of clinical phenotypes cause diagnostic and therapeutic problems and this is the basis for the division of the disease into subtypes. Heterogeneity of the disease is also confirmed in the study of the genotype of the disease. In relation with AZS more than 1000 loci in chromosomes were demonstrated...
August 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28869773/antioxidant-consumption-is-associated-with-decreased-odds-of-congenital-limb-deficiencies
#16
Nelson D Pace, Tania A Desrosiers, Suzan L Carmichael, Gary M Shaw, Andrew F Olshan, Anna Maria Siega-Riz
BACKGROUND: Approximately 1 in 2000 infants is born with a limb deficiency in the US. Research has shown that women's periconceptional diet and use of vitamin supplements can affect risk of birth defects. We investigated whether maternal consumption of nutritional antioxidants was associated with occurrence of transverse limb deficiency (TLD) and longitudinal limb deficiencies (LLD). METHODS: We analysed case-control data from mothers and their singleton infants with TLD (n = 566), LLD (n = 339), or no malformation (controls; n = 9384) in the National Birth Defects Prevention Study (1997-2009)...
September 4, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28868323/fetal-alcohol-exposure-the-common-toll
#17
Marie R Nakhoul, Karl E Seif, Natasha Haddad, Georges E Haddad
Alcohol has always been present in human life, and currently it is estimated that 50% of women of childbearing age consume alcohol. It has become increasingly clear over the last years that alcohol exposure during fetal development can have detrimental effects on various organ systems, and these effects are exerted by alcohol through multiple means, including effects on free radical formation, cellular apoptosis, as well as gene expression. Fetal alcohol exposure can lead to a spectrum of short term as well as long-term problems, with Fetal Alcohol Syndrome being on the more severe end of that spectrum...
February 2017: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/28866664/smoking-trajectories-during-the-perinatal-period-and-their-risk-factors-the-nationally-representative-french-elfe-etude-longitudinale-fran%C3%A3-aise-depuis-l-enfance-birth-cohort-study
#18
Fabienne El-Khoury, Anne-Laure Sutter-Dallay, Judith Van Der Waerden, Pamela Surkan, Silvia Martins, Katherine Keyes, Blandine de Lauzon-Guillain, Marie-Aline Charles, Maria Melchior
BACKGROUND: In France, rates of perinatal smoking are among the highest worldwide; however, perinatal smoking trajectories and associated factors have still not been adequately researched. METHODS: Among women participating in the French nationally representative etude longitudinale française depuis l'enfance birth cohort (n = 15,540), perinatal smoking trajectories were estimated using group-based modelling. Associated characteristics were studied using multinomial logistic regression...
September 2, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28864983/epigenetic-influences-during-the-periconception-period-and-assisted-reproduction
#19
Akwasi A Amoako, Tamer M Nafee, Bolarinde Ola
The periconception period starts 6 months before conception and lasts until the tenth week of gestation. In this chapter, we will focus on epigenetic modifications to DNA and gene expression within this period and during assisted reproduction. There are two critical times during the periconception window when significant epigenetic 'reprogramming' occur: one during gametogenesis and another during the pre-implantation embryonic stage. Furthermore, assisted conception treatments, laboratory protocols and culture media can affect the embryo development and birth weights in laboratory animals...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28859770/no-245-alcohol-use-and-pregnancy-consensus-clinical-guidelines
#20
George Carson, Lori Vitale Cox, Joan Crane, Pascal Croteau, Lisa Graves, Sandra Kluka, Gideon Koren, Marie-Jocelyne Martel, Deana Midmer, Irena Nulman, Nancy Poole, Vyta Senikas, Rebecca Wood
OBJECTIVE: To establish national standards of care for the screening and recording of alcohol use and counselling on alcohol use of women of child-bearing age and pregnant women based on the most up-to-date evidence. EVIDENCE: Published literature was retrieved through searches of PubMed, CINAHL, and the Cochrane Library in May 2009 using appropriate controlled vocabulary (e.g., pregnancy complications, alcohol drinking, prenatal care) and key words (e.g., pregnancy, alcohol consumption, risk reduction)...
September 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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