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Ethanol pregnancy

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https://www.readbyqxmd.com/read/28081369/randomized-controlled-ethanol-cookstove-intervention-and-blood-pressure-in-pregnant-nigerian-women
#1
Donee Alexander, Amanda Northcross, Nathaniel Wilson, Anindita Dutta, Rishi Pandya, Tope Ibigbami, Damilola Adu, John Olamijulo, Oludare Morhason-Bello, Theodore Karrison, Oladosu Ojengbede, Christopher O Olopade
RATIONALE: Hypertension during pregnancy is a leading cause of maternal mortality. Exposure to household air pollution (HAP) elevates blood pressure (BP). OBJECTIVES: Investigate ability of clean cookstove intervention to lower BP during pregnancy. METHODS: A randomized, controlled trial (RCT) was conducted in Nigeria. Pregnant women cooking with kerosene or firewood were randomly assigned to ethanol (n = 162) or control arms (n = 162). BP measurements were taken during 6 antenatal visits...
January 12, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28071021/the-effect-of-alcohol-consumption-on-maternal-and-cord-blood-electrolyte-and-trace-element-levels
#2
Anatoly V Skalny, Elena S Berezkina, Elena V Kiyaeva, Inara E Alidzhanova, Andrew R Grabeklis, Alexey A Tinkov
BACKGROUND: Earlier studies demonstrated that alcoholism significantly alters electrolyte and trace element homeostasis. However, the existing data on the interplay between maternal alcohol consumption and fetal trace element status are contradictory. Therefore, the primary objective of the present study was to assess the influence of alcohol consumption on maternal and cord blood trace elements. METHODS: A total of 30 pregnant women (15 women consuming alcohol and 15 controls) were examined...
October 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28069986/mechanisms-involved-in-porcine-early-embryo-survival-following-ethanol-exposure
#3
Florence Pagé-Larivière, Céline Campagna, Marc-André Sirard
Alcohol consumption during pregnancy is still a cause of preventable birth defects and developmental disabilities. However, little is known about the impact of ethanol on preimplantation embryos and the molecular mechanisms involved. We aimed to determine the toxicogenomic impacts and the mechanisms involved in preimplantation embryonic survival following 0.2% ethanol exposure in porcine embryos. Gene expression changes were measured with a porcine embryo specific microarray and confirmed by RT-qPCR. Compared to control, ethanol exposure led to a 43% decrease in blastocyst rate and activated pathways associated with oxidative stress and nervous system damage, such as TP53 and TGF...
January 9, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28062893/prenatal-alcohol-induced-neuroapoptosis-in-rat-brain-cerebral-cortex-protective-effect-of-folic-acid-and-betaine
#4
Ibrahim Sogut, Onur Uysal, Aysegul Oglakci, Ferruh Yucel, Kazim Kartkaya, Gungor Kanbak
PURPOSE: Alcohol consumption in pregnancy may cause fetal alcohol syndrome (FAS) in the infant. This study aims to investigate prenatal alcohol exposure related neuroapoptosis on the cerebral cortex tissues of newborn rats and possible neuroprotective effects of betaine, folic acid, and combined therapy. METHODS: Pregnant rats were divided into five experimental groups: control, ethanol, ethanol + betaine, ethanol + folic acid, and ethanol + betaine + folic acid combined therapy groups...
January 6, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27935818/prenatal-ethanol-exposure-phenocopies-cdon-mutation-by-impeding-shh-function-in-the-etiology-of-optic-nerve-hypoplasia
#5
Benjamin M Kahn, Tanya S Corman, Korah Lovelace, Mingi Hong, Robert S Krauss, Douglas J Epstein
Septo-optic dysplasia (SOD) is a congenital disorder characterized by optic nerve, pituitary and midline brain malformations. The clinical presentation of SOD is highly variable with a poorly understood etiology. The majority of SOD cases are sporadic, but in rare instances inherited mutations have been identified in a small number of transcription factors, some of which regulate the expression of Sonic hedgehog (Shh) during mouse forebrain development. SOD is also associated with young maternal age suggesting that environmental factors, including alcohol consumption at early stages of pregnancy, may increase the risk of developing this condition...
November 24, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27888055/dietary-choline-levels-modify-the-effects-of-prenatal-alcohol-exposure-in-rats
#6
Nirelia M Idrus, Kristen R Breit, Jennifer D Thomas
Prenatal alcohol exposure can cause a range of physical and behavioral alterations; however, the outcome among children exposed to alcohol during pregnancy varies widely. Some of this variation may be due to nutritional factors. Indeed, higher rates of fetal alcohol spectrum disorders (FASD) are observed in countries where malnutrition is prevalent. Epidemiological studies have shown that many pregnant women throughout the world may not be consuming adequate levels of choline, an essential nutrient critical for brain development, and a methyl donor...
November 23, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27862017/the-effects-of-ethanol-exposure-during-distinct-periods-of-brain-development-on-oxidative-stress-in-the-adult-rat-brain
#7
Patricia S Brocardo, Joana Gil-Mohapel, Ryan Wortman, Athena Noonan, Eric McGinnis, Anna R Patten, Brian R Christie
BACKGROUND: The consumption of alcohol during pregnancy can result in abnormal fetal development and impaired brain function in humans and experimental animal models. Depending on the pattern of consumption, the dose, and the period of exposure to ethanol (EtOH), a variety of structural and functional brain deficits can be observed. METHODS: This study compared the effects of EtOH exposure during distinct periods of brain development on oxidative damage and endogenous antioxidant status in various brain regions of adult female and male Sprague Dawley rats...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27812507/gene-expression-in-the-mouse-brain-following-early-pregnancy-exposure-to-ethanol
#8
Christine R Zhang, Suyinn Chong
Exposure to alcohol during early embryonic or fetal development has been linked with a variety of adverse outcomes, the most common of which are structural and functional abnormalities of the central nervous system [1]. Behavioural and cognitive deficits reported in individuals exposed to alcohol in utero include intellectual impairment, learning and memory difficulties, diminished executive functioning, attention problems, poor motor function and hyperactivity [2]. The economic and social costs of these outcomes are substantial and profound [3], [4]...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27788773/maternal-choline-supplementation-in-a-sheep-model-of-first-trimester-binge-alcohol-fails-to-protect-against-brain-volume-reductions-in-peripubertal-lambs
#9
Sharla M Birch, Mark W Lenox, Joe N Kornegay, Beatriz Paniagua, Martin A Styner, Charles R Goodlett, Tim A Cudd, Shannon E Washburn
Fetal alcohol spectrum disorder (FASD) is a leading potentially preventable birth defect. Poor nutrition may contribute to adverse developmental outcomes of prenatal alcohol exposure, and supplementation of essential micronutrients such as choline has shown benefit in rodent models. The sheep model of first-trimester binge alcohol exposure was used in this study to model the dose of maternal choline supplementation used in an ongoing prospective clinical trial involving pregnancies at risk for FASD. Primary outcome measures including volumetrics of the whole brain, cerebellum, and pituitary derived from magnetic resonance imaging (MRI) in 6-month-old lambs, testing the hypothesis that alcohol-exposed lambs would have brain volume reductions that would be ameliorated by maternal choline supplementation...
September 2016: Alcohol
https://www.readbyqxmd.com/read/27697226/alcohol-exposure-impairs-trophoblast-survival-and-alters-subtype-specific-gene-expression-in%C3%A2-vitro
#10
J I Kalisch-Smith, J E Outhwaite, D G Simmons, M Pantaleon, K M Moritz
Maternal alcohol consumption is common prior to pregnancy recognition and in the rat results in altered placental development and fetal growth restriction. To assess the effect of ethanol (EtOH) exposure on the differentiation of trophoblast stem (TS) cells, mouse TS lines were differentiated in vitro for 6 days in 0%, 0.2% or 1% EtOH. This reduced both trophoblast survival and expression of labyrinth and junctional zone trophoblast subtype-specific genes. This suggests that fetal growth restriction and altered placental development associated with maternal alcohol consumption in the periconceptional period could be mediated in part by direct effects on trophoblast development...
October 2016: Placenta
https://www.readbyqxmd.com/read/27565755/did-you-drink-alcohol-during-pregnancy-inaccuracy-and-discontinuity-of-women-s-self-reports-on-the-way-to-establish-meconium-ethyl-glucuronide-etg-as-a-biomarker-for-alcohol-consumption-during-pregnancy
#11
Anna Eichler, Juliane Grunitz, Jennifer Grimm, Lisa Walz, Eva Raabe, Tamme W Goecke, Matthias W Beckmann, Oliver Kratz, Hartmut Heinrich, Gunther H Moll, Peter A Fasching, Johannes Kornhuber
Consuming alcohol during pregnancy is one of the most verified prenatal risk factors for impaired child development. Information about the amount of alcohol consumed prenatally is needed to anticipate negative effects and to offer timely support. Women's self-reports are not reliable, often influenced by social stigmas and retrospective recall bias, causing biomarkers of intrauterine ethanol exposure to become more and more relevant. The present study compares both women's gestational and retrospective self-reports of prenatal alcohol consumption with levels of ethyl glucuronide (EtG) in meconium...
August 2016: Alcohol
https://www.readbyqxmd.com/read/27565750/effect-of-prenatal-ethanol-exposure-on-sexual-motivation-in-adult-rats
#12
Mara Aparecida P Ávila, Gabriela Cristina P Marthos, Liliane Gibram M Oliveira, Eduardo Costa Figueiredo, Alexandre Giusti-Paiva, Fabiana Cardoso Vilela
Maternal alcohol use during pregnancy adversely affects prenatal and postnatal growth and increases the risk of behavioral deficits. The aim of the present study was to evaluate the effect of prenatal exposure to a moderate dose of alcohol on sexual motivation during adulthood. Rats were prenatally exposed to ethanol by feeding pregnant dams a liquid diet containing 25% ethanol-derived calories on days 6 through 19 of gestation. The controls consisted of pair-fed dams (receiving an isocaloric liquid diet containing 0% ethanol-derived calories) and dams with ad libitum access to a liquid control diet...
August 2016: Alcohol
https://www.readbyqxmd.com/read/27537918/ethanol-induced-neurodegeneration-and-glial-activation-in-the-developing-brain
#13
REVIEW
Mariko Saito, Goutam Chakraborty, Maria Hui, Kurt Masiello, Mitsuo Saito
Ethanol induces neurodegeneration in the developing brain, which may partially explain the long-lasting adverse effects of prenatal ethanol exposure in fetal alcohol spectrum disorders (FASD). While animal models of FASD show that ethanol-induced neurodegeneration is associated with glial activation, the relationship between glial activation and neurodegeneration has not been clarified. This review focuses on the roles of activated microglia and astrocytes in neurodegeneration triggered by ethanol in rodents during the early postnatal period (equivalent to the third trimester of human pregnancy)...
August 16, 2016: Brain Sciences
https://www.readbyqxmd.com/read/27462100/inflammatory-responses-to-alcohol-in-the-cns-nuclear-receptors-as-potential-therapeutics-for-alcohol-induced-neuropathologies
#14
REVIEW
Cynthia J M Kane, Paul D Drew
Fetal alcohol spectrum disorder (FASD), which results from ethanol exposure during pregnancy, and alcohol use disorder (AUD), which includes both binge and chronic alcohol abuse, are strikingly common and costly at personal and societal levels. These disorders are associated with significant pathology, including that observed in the CNS. It is now appreciated in both humans and animal models that ethanol can induce inflammation in the CNS. Neuroinflammation is hypothesized to contribute to the neuropathologic and behavioral consequences in FASD and AUD...
November 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27458336/genetic-syndromes-maternal-diseases-and-antenatal-factors-associated-with-autism-spectrum-disorders-asd
#15
REVIEW
Asher Ornoy, Liza Weinstein-Fudim, Zivanit Ergaz
Autism spectrum disorder (ASD) affecting about 1% of all children is associated, in addition to complex genetic factors, with a variety of prenatal, perinatal, and postnatal etiologies. In addition, ASD is often an important clinical presentation of some well-known genetic syndromes in human. We discuss these syndromes as well as the role of the more important prenatal factors affecting the fetus throughout pregnancy which may also be associated with ASD. Among the genetic disorders we find Fragile X, Rett syndrome, tuberous sclerosis, Timothy syndrome, Phelan-McDermid syndrome, Hamartoma tumor syndrome, Prader-Willi and Angelman syndromes, and a few others...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27437703/is-breast-cancer-risk-associated-with-alcohol-intake-before-first-full-term-pregnancy
#16
Harindra Jayasekara, Robert J MacInnis, Allison M Hodge, Robin Room, Roger L Milne, John L Hopper, Graham G Giles, Dallas R English
PURPOSE: It is plausible that breast tissue is particularly susceptible to carcinogens, including ethanol, between menarche and the first full-term pregnancy ("first pregnancy"). There is some epidemiological evidence that intake before the first pregnancy is more closely associated with risk of breast cancer than is intake thereafter. We examined this association using lifetime alcohol consumption data from a prospective cohort study. METHODS: We calculated usual alcohol intake for age periods 15-19 years and for 10-year period from age 20 to current age (in grams per day) using recalled frequency and quantity of beverage-specific consumption for 13,630 parous women who had their first pregnancy at age 20 years or later, had no cancer history and were aged 40-69 years at enrollment...
September 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27422904/alcohol-exposure-leads-to-unrecoverable-cardiovascular-defects-along-with-edema-and-motor-function-changes-in-developing-zebrafish-larvae
#17
Xu Li, Aiai Gao, Yanan Wang, Man Chen, Jun Peng, Huaying Yan, Xin Zhao, Xizeng Feng, Dongyan Chen
Maternal alcohol consumption during pregnancy can cause a series of developmental disorders in the fetus called FAS (fetal alcohol syndrome). In the present study we exposed zebrafish embryos to 1% and 2% alcohol and observed the morphology of heart and blood vessels during and after exposure to investigate motor function alterations, and damage and recovery to the cardiovascular system. The results showed that alcohol exposure could induce heart deformation, slower heart rate, and incomplete blood vessels and pericardium...
2016: Biology Open
https://www.readbyqxmd.com/read/27375424/third-trimester-equivalent-alcohol-exposure-reduces-modulation-of-glutamatergic-synaptic-transmission-by-5-ht1a-receptors-in-the-rat-hippocampal-ca3-region
#18
Russell A Morton, C Fernando Valenzuela
Fetal alcohol exposure has been associated with many neuropsychiatric disorders that have been linked to altered serotonin (5-hydroxytryptamine; 5-HT) signaling, including depression and anxiety. During the first 2 weeks of postnatal life in rodents (equivalent to the third trimester of human pregnancy) 5-HT neurons undergo significant functional maturation and their axons reach target regions in the forebrain (e.g., cortex and hippocampus). The objective of this study was to identify the effects of third trimester ethanol (EtOH) exposure on hippocampal 5-HT signaling...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27330832/study-of-the-effects-of-diazinon-on-fetal-liver-in-balb-c-mice
#19
Fatemeh Saraei, Mehrangiz Sadoughi, Gholamreza Kaka, Seyed Homayoon Sadraie, Mohsen Foaddodini
BACKGROUND: Diazinon is an organophosphate that is broadly used as a pesticide to control insects and environmental pollutions. This toxic material is absorbed via inhalation, contact, or digestion and affects different tissues. OBJECTIVES: This research was a histomorphometric and immunohistochemical study of the fetal liver of mice after exposure to Diazinon. MATERIALS AND METHODS: Twenty-five pregnant BALB/c mice (25 - 30 gr) were divided into five equal groups in the animal lab of Baqiyatallah University of Medical Sciences, Tehran, Iran...
April 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27299903/prevalence-of-ethanol-use-among-pregnant-women-in-southwestern-uganda
#20
L L English, G Mugyenyi, I Nightingale, G Kiwanuka, J Ngonzi, B E Grunau, S MacLeod, G Koren, K Delano, J Kabakyenga, M O Wiens
Introduction The prevalence of ethanol use in many Sub-Saharan African countries is high, but little research exists on use during pregnancy. The objective of this study was to assess the prevalence and predictors of ethanol use among pregnant women in Southwestern Uganda. Methods This descriptive, cross-sectional study was conducted in the maternity ward at Mbarara Regional Referral Hospital (MRRH). All pregnant women giving birth at MRRH between September 23, 2013 and November 23, 2013 were eligible for enrollment...
October 2016: Maternal and Child Health Journal
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