keyword
https://read.qxmd.com/read/37400801/clinical-significance-of-high-monocyte-counts-for-the-continuous-treatment-with-nintedanib
#21
JOURNAL ARTICLE
Shingo Tsuneyoshi, Yoshiaki Zaizen, Masaki Tominaga, Goushi Matama, Shushi Umemoto, Shuuhei Ohno, Reiko Takaki, Ryo Yano, Kenta Murotani, Masaki Okamoto, Tomoaki Hoshino
BACKGROUND: Nintedanib is now widely used to treat interstitial lung disease (ILD). Adverse events, which occur in not a few patients, make it difficult to continue nintedanib treatment, but the risk factors for adverse events are not well understood. METHODS: In this retrospective cohort study, we enrolled 111 patients with ILDs treated with nintedanib and investigated the factors involved in starting dosage reduction, withdrawal, or discontinuation within 12 months, even with appropriate symptomatic treatment...
July 3, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/37126360/imi-management-and-investigation-of-high-myopia-in-infants-and-young-children
#22
JOURNAL ARTICLE
Ian Flitcroft, John Ainsworth, Audrey Chia, Susan Cotter, Elise Harb, Zi-Bing Jin, Caroline C W Klaver, Anthony T Moore, Ken K Nischal, Kyoko Ohno-Matsui, Evelyn A Paysse, Michael X Repka, Irina Y Smirnova, Martin Snead, Virginie J M Verhoeven, Pavan K Verkicharla
PURPOSE: The purpose of this study was to evaluate the epidemiology, etiology, clinical assessment, investigation, management, and visual consequences of high myopia (≤-6 diopters [D]) in infants and young children. FINDINGS: High myopia is rare in pre-school children with a prevalence less than 1%. The etiology of myopia in such children is different than in older children, with a high rate of secondary myopia associated with prematurity or genetic causes...
May 1, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/37108583/neural-isoforms-of-agrin-are-generated-by-reduced-ptbp1-rna-interaction-network-spanning-the-neuron-specific-splicing-regions-in-agrn
#23
JOURNAL ARTICLE
Samira Bushra, Ying-Ni Lin, Atefeh Joudaki, Mikako Ito, Bisei Ohkawara, Kinji Ohno, Akio Masuda
Agrin is a heparan sulfate proteoglycan essential for the clustering of acetylcholine receptors at the neuromuscular junction. Neuron-specific isoforms of agrin are generated by alternative inclusion of three exons, called Y, Z8, and Z11 exons, although their processing mechanisms remain elusive. We found, by inspection of splicing cis -elements into the human AGRN gene, that binding sites for polypyrimidine tract binding protein 1 (PTBP1) were extensively enriched around Y and Z exons. PTBP1 -silencing enhanced the coordinated inclusion of Y and Z exons in human SH-SY5Y neuronal cells, even though three constitutive exons are flanked by these alternative exons...
April 18, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37103112/blueberry-stem-extract-prevents-lacrimal-hyposecretion-in-non-obese-diabetic-mice-via-activation-of-ampk
#24
JOURNAL ARTICLE
Kenjirou Ogawa, Yuta Ohno, Akane Tagashira, Karin Urata, Keitaro Satoh, Naruki Fujimoto, Hiroko Sonoda, Masahiro Ikeda, Toshiyuki Matsuzaki, Kazuo Nishiyama, Hisato Kunitake, Y O Goto, Masao Yamasaki
BACKGROUND/AIM: Tears secreted from the lacrimal gland are essential for preserving the ocular surface. Thus, dysfunction of the lacrimal gland in Sjögren's syndrome (SS) can lead to dry eye, resulting in a reduced quality of life. We previously reported that blueberry 'leaf' water extract prevents lacrimal hyposecretion in male non-obese diabetic (NOD) mice in a SS-like model. In this study, we investigated the effect of blueberry 'stem' water extract (BStEx) on lacrimal hyposecretion in NOD mice...
2023: In Vivo
https://read.qxmd.com/read/36964865/detection-of-merkel-cell-polyomavirus-in-multiple-primary-oral-squamous-cell-carcinomas
#25
JOURNAL ARTICLE
Naoya Kitamura, Yumiko Hashida, Tomonori Higuchi, Seiji Ohno, Shinya Sento, Eri Sasabe, Ichiro Murakami, Tetsuya Yamamoto, Masanori Daibata
Oral microbiome studies have mainly focussed on bacteria, with the relationship between viruses and oral cancers remaining poorly understood. Oral cancers can develop even in the absence of any history of daily smoking or drinking. Oral cancer patients frequently have multiple primary cancers in the oral cavity and other organs, such as the upper gastrointestinal tract. Merkel cell polyomavirus (MCPyV) is a novel oncovirus identified from a subtype of skin cancer in 2008. In this study, we investigated the potential involvement of MCPyV in the pathogenesis of oral squamous cell carcinoma (OSCC)...
March 25, 2023: Odontology
https://read.qxmd.com/read/36961616/clinical-value-of-minimum-apparent-diffusion-coefficient-for-prediction-of-clinically-significant-prostate-cancer-in-the-transition-zone
#26
JOURNAL ARTICLE
Ashita Ono, Takeshi Hashimoto, Toshihide Shishido, Yosuke Hirasawa, Naoya Satake, Kazunori Namiki, Kazuhiro Saito, Yoshio Ohno
BACKGROUND: This study investigated the association between apparent diffusion coefficients in Prostate Imaging Reporting and Data System 4/5 lesions and clinically significant prostate cancer in the transition zone. METHODS: We included 102 patients who underwent transperineal cognitive fusion targeted biopsy for Prostate Imaging Reporting and Data System 4/5 lesions in the transition zone between 2016 and 2020. The association between apparent diffusion coefficients and prostate cancers in the transition zone was analyzed...
March 24, 2023: International Journal of Clinical Oncology
https://read.qxmd.com/read/36854494/effect-of-mirtazapine-for-the-prevention-of-nausea-and-vomiting-in-patients-with-thoracic-cancer-receiving-platinum-based-chemotherapy
#27
JOURNAL ARTICLE
Motohiko Kinomura, Hirotoshi Iihara, Hironori Fujii, Chiemi Hirose, Junki Endo, Komei Yanase, Toshiya Inui, Daizo Kaito, Yuka Sasaki, Takenobu Gomyo, Chizuru Sakai-Masuda, Daisuke Kawae, Y U Kitamura, Masachika Fukui, Ryo Kobayashi, Yasushi Ohno, Akio Suzuki
BACKGROUND/AIM: Mirtazapine, which exerts an antagonistic effect on 5-hydroxytryptamine type 5-HT2A , 5-HT2C , 5-HT3 and H1 receptors, is considered useful for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV). This study investigated the efficacy and safety of mirtazapine for the prevention of CINV in patients with thoracic cancer receiving platinum-based chemotherapy. PATIENTS AND METHODS: A retrospective cohort study was conducted in patients with thoracic cancer receiving platinum-based chemotherapy with 15 mg mirtazapine once daily as a prophylactic antiemetic drug between January 2014 and December 2021...
March 2023: Anticancer Research
https://read.qxmd.com/read/36690708/phase-ii-study-comparing-nasal-pressure-monitoring-with-capnography-during-invasive-endoscopic-procedures-a-single-center-single-arm-trial
#28
JOURNAL ARTICLE
Hiroki Nagashima, Rintaro Mikata, Shiroh Isono, Sadahisa Ogasawara, Harutoshi Sugiyama, Izumi Ohno, Shin Yasui, Tomoaki Matsumura, Keisuke Koroki, Yuko Kusakabe, Yoshifumi Miura, Motoyasu Kan, Shikiko Maruta, Toshihito Yamada, Ryo Takemura, Yasunori Sato, Jun Kato, Naoya Kato
Nasal pressure signal is commonly used to evaluate obstructive sleep apnea. This study aimed to assess its safety for respiratory monitoring during sedation. A total of 45 adult patients undergoing sedation with propofol and fentanyl for invasive endoscopic procedures were enrolled. While both nasal pressure and capnograph signals were continuously recorded, only the nasal pressure signal was displayed. The primary outcome was the incidence of oxygen desaturation below 90%. The secondary outcomes were the ability to predict the desaturation and incidence of harmful events and false alarms, defined as an apnea waveform lasting more than 3 min without desaturation...
January 23, 2023: Scientific Reports
https://read.qxmd.com/read/36624564/late-onset-chronic-kidney-disease-over-2-decades-after-pediatric-liver-transplantation-a-single-center-retrospective-study
#29
JOURNAL ARTICLE
Kentaro Umemura, Atsuyoshi Mita, Yasunari Ohno, Yuichi Masuda, Kazuki Yoshizawa, Koji Kubota, Tsuyoshi Notake, Kiyotaka Hosoda, Atsushi Kamachi, Takamune Goto, Hidenori Tomida, Shiori Yamazaki, Akira Shimizu, Yuji Soejima
BACKGROUND: Although chronic kidney disease (CKD) after liver transplantation (LTx) is a common complication in adults, its long-term significance after pediatric LTx remains unclear. We examined the decades-long transition of renal function and revealed the risk factors for late-onset CKD after pediatric LTx in a single-center retrospective cohort of 117 pediatric LTx recipients who survived >5 y. METHODS: The estimated glomerular filtration rate (eGFR) and CKD stages were calculated using serum creatinine...
January 10, 2023: Transplantation
https://read.qxmd.com/read/36623548/early-release-science-of-the-exoplanet-wasp-39b-with-jwst-nirspec-prism
#30
JOURNAL ARTICLE
Z Rustamkulov, D K Sing, S Mukherjee, E M May, J Kirk, E Schlawin, M R Line, C Piaulet, A L Carter, N E Batalha, J M Goyal, M López-Morales, J D Lothringer, R J MacDonald, S E Moran, K B Stevenson, H R Wakeford, N Espinoza, J L Bean, N M Batalha, B Benneke, Z K Berta-Thompson, I J M Crossfield, P Gao, L Kreidberg, D K Powell, P E Cubillos, N P Gibson, J Leconte, K Molaverdikhani, N K Nikolov, V Parmentier, P Roy, J Taylor, J D Turner, P J Wheatley, K Aggarwal, E Ahrer, M K Alam, L Alderson, N H Allen, A Banerjee, S Barat, D Barrado, J K Barstow, T J Bell, J Blecic, J Brande, S Casewell, Q Changeat, K L Chubb, N Crouzet, T Daylan, L Decin, J Désert, T Mikal-Evans, A D Feinstein, L Flagg, J J Fortney, J Harrington, K Heng, Y Hong, R Hu, N Iro, T Kataria, E M-R Kempton, J Krick, M Lendl, J Lillo-Box, A Louca, J Lustig-Yaeger, L Mancini, M Mansfield, N J Mayne, Y Miguel, G Morello, K Ohno, E Palle, D J M Petit Dit de la Roche, B V Rackham, M Radica, L Ramos-Rosado, S Redfield, L K Rogers, E L Shkolnik, J Southworth, J Teske, P Tremblin, G S Tucker, O Venot, W C Waalkes, L Welbanks, X Zhang, S Zieba
Transmission spectroscopy1,2,3 of exoplanets has revealed signatures of water vapor, aerosols, and alkali metals in a few dozen exoplanet atmospheres4,5 . However, these previous inferences with the Hubble and Spitzer Space Telescopes were hindered by the observations' relatively narrow wavelength range and spectral resolving power, which precluded the unambiguous identification of other chemical species - in particular the primary carbon-bearing molecules6,7 . Here we report a broad-wavelength 0.5-5.5 µm atmospheric transmission spectrum of WASP39 b8 , a 1200 K, roughly Saturn-mass, Jupiter-radius exoplanet, measured with JWST NIRSpec's PRISM mode9 as part of the JWST Transiting Exoplanet Community Early Release Science Team program10,11,12 ...
January 9, 2023: Nature
https://read.qxmd.com/read/36609695/association-of-poor-oral-health-status-and-faecal-incontinence-in-patients-with-dysphagia-a-cross-sectional-analysis-from-the-sarcopenic-dysphagia-database
#31
MULTICENTER STUDY
Akio Shimizu, Hiroki Maki, Tomohisa Ohno, Akiko Nomoto, Ichiro Fujishima, Jun Kayashita, Ryo Momosaki, Shinta Nishioka, Hidetaka Wakabayashi
BACKGROUND: Poor oral health status may alter oral and gut microbiota. Previous studies have shown that poor oral health can exacerbate gut inflammation. Therefore, poor oral health status may be related to faecal incontinence via changes in the gut. OBJECTIVE: To investigate the association between poor oral health status and faecal incontinence in inpatients with dysphagia. METHODS: This multicentre cross-sectional study included 423 patients (mean age 79...
April 2023: Journal of Oral Rehabilitation
https://read.qxmd.com/read/36593026/blueberry-leaf-extract-prevents-lacrimal-hyposecretion-in-sj%C3%A3-gren-s-syndrome-like-model-of-non-obese-diabetic-mice
#32
JOURNAL ARTICLE
Kenjirou Ogawa, Karin Urata, Saki Maeda, Yuta Ohno, Keitaro Satoh, Yoshiyuki Yamada, Yosuke Suzuki, Yasuko Koga, Kazuhiro Sugamoto, Makiko Kawaguchi, Hisato Kunitake, Kazuo Nishiyama, Y O Goto, Takayuki Nakayama, Masao Yamasaki
BACKGROUND/AIM: This study evaluated the effect of blueberry leaf hot water extract (BLEx) on Sjögren's syndrome (SS)-like lacrimal hyposecretion in male non-obese diabetic (NOD) mice. MATERIALS AND METHODS: NOD or BALB/c mice were fed 1% BLEx or control (AIN-93G) for 2 weeks from the age of 4 to 6 weeks. Pilocarpine-induced tear volume was measured using a phenol red-impregnated thread. The lacrimal glands were evaluated histologically by H&E staining...
2023: In Vivo
https://read.qxmd.com/read/36575003/myc-bcl2-double-and-myc-bcl2-bcl6-triple-hit-follicular-lymphomas-associated-with-t-8-14-18-q24-q32-q21
#33
JOURNAL ARTICLE
Kayo Takeoka, Fumiyo Maekawa, Miho Nakagawa, Chiyuki Kishimori, Katsuhiro Fukutsuka, Masahiko Hayashida, Shinji Sumiyoshi, Hitoshi Ohno
We describe two follicular lymphoma (FL) patients with MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit translocations. The first patient (case 1) was a man in his 30s who presented with stage IV disease with leukemic manifestation. The second patient (case 2) was a man in his 60s who presented with relapsed FL, but his disease was in a limited stage. Histopathology of the lymph node biopsies revealed grade 3A FL in both cases. MYC positivity and the Ki-67-labeling index were 60-70 and 20% in case 1 and 30 and 50% in case 2, respectively...
2022: Journal of Clinical and Experimental Hematopathology: JCEH
https://read.qxmd.com/read/36343043/feasibility-of-endoscopic-ultrasound-guided-hepaticogastrostomy-using-a-22-gauge-needle
#34
JOURNAL ARTICLE
Koji Takahashi, Hiroshi Ohyama, Mayu Ouchi, Motoyasu Kan, Hiroki Nagashima, Yotaro Iino, Yuko Kusakabe, Kohichiroh Okitsu, Izumi Ohno, Yuichi Takiguchi, Naoya Kato
This study aimed to evaluate the feasibility of performing endoscopic ultrasound-guided hepaticogastrostomy using a 22-gauge fine-needle aspiration needle. This was a single-center retrospective study. Fourteen patients who underwent endoscopic ultrasound-guided hepaticogastrostomy with a 22-gauge fine-needle aspiration needle were examined. Fourteen eligible patients were included in this study. The age of patients ranged from 55 to 93 years, with a median of 76 years. Of patients with existing underlying diseases, there were 8 cases of pancreatic cancer (57...
November 4, 2022: Medicine (Baltimore)
https://read.qxmd.com/read/36319814/prevalence-and-characteristics-of-dry-eye-disease-in-parkinson-s-disease-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Ken Nagino, Jaemyoung Sung, Genko Oyama, Motoshi Hayano, Nobutaka Hattori, Yuichi Okumura, Kenta Fujio, Yasutsugu Akasaki, Tianxiang Huang, Akie Midorikawa-Inomata, Keiichi Fujimoto, Atsuko Eguchi, Shokirova Hurramhon, Maria Miura, Mizu Ohno, Kunihiko Hirosawa, Yuki Morooka, Akira Murakami, Hiroyuki Kobayashi, Takenori Inomata
We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson's disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian-Laird random-effects model. Prevalence of subjective DED symptoms in patients with PD and mean differences in blink rate, corneal thickness, tear film breakup time, and tear secretion volume on Schirmer test I were compared to those in controls...
November 1, 2022: Scientific Reports
https://read.qxmd.com/read/36288979/effects-of-aging-and-reproductive-history-on-bone-parameters-of-common-marmoset-callithrix-jacchus-mandibles
#36
JOURNAL ARTICLE
Kazutoshi Nishijima, Ryoichi Saito, Tamio Ohno, Shin Tanaka
To understand effects of aging and reproductive history in the bones of common marmosets (Callithrix jacchus), mandibles from 79 males and 66 females were analyzed. Dry bone specimen was prepared from dissected mandible, and analyzed using a dual-energy x-ray absorptiometry (DXA) measurement system in terms of bone weight (BnW), bone area (AREA), bone mineral content (BMC), bone mineral density (BMD, ratio of BMC to AREA) and bone mineral ratio (BMR, ratio of BMC to BnW). The mandible bones became porous and thicker with age...
October 27, 2022: Experimental Animals
https://read.qxmd.com/read/36206307/immunization-with-inactivated-whole-virus-particle-influenza-virus-vaccines-improves-the-humoral-response-landscape-in-cynomolgus-macaques
#37
JOURNAL ARTICLE
Brendon Y Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C Rowntree, Thi H O Nguyen, Hayley A McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Yasushi Itoh, Jennifer R Habel, Kevin J Selva, Adam K Wheatley, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, David C Jackson, Lorena E Brown, Masashi Shingai, Katherine Kedzierska, Hiroshi Kida
Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their efficacy can be modest, especially in immunologically-naïve individuals. We investigated immune responses towards inactivated whole influenza virus particle vaccine (WPV) formulations, predicated to be more immunogenic, in a non-human primate model, as an important step towards clinical testing in humans. Comprehensive analyses were used to capture 46 immune parameters to profile how WPV-induced responses differed to those elicited by antigenically-similar SV formulations...
October 7, 2022: PLoS Pathogens
https://read.qxmd.com/read/36199179/influence-of-using-history-of-immune-checkpoint-inhibitor-therapy-for-neutropenia-caused-by-combination-therapy-of-ramucirumab-and-docetaxel
#38
JOURNAL ARTICLE
H Ohno, S Mano, N Katagiri, R Oguri, K Miyazaki, K Ito, Y Sekiya, K Inoue, A Masuda, A Tsuzuku, F Asano, T Hirashita, T Hayashi
Recently, pretreatment with immune checkpoint inhibitors (ICIs) has been shown to enhance the therapeutic effects of the combination therapy of ramucirumab (RAM) and docetaxel (DTX); however, its influence on the drug's side effects remains unclear. This study investigated the influence of pretreatment with ICIs on the incidence of neutropenia caused by RAM + DTX therapy in patients with non-small cell lung cancer (NSCLC). Patients with NSCLC who received RAM + DTX therapy at Gifu Prefectural General Medical Center between April 2016 and December 2020 were enrolled...
September 1, 2022: Die Pharmazie
https://read.qxmd.com/read/36194579/distinct-phosphorylation-states-of-mammalian-camkii%C3%AE-control-the-induction-and-maintenance-of-sleep
#39
JOURNAL ARTICLE
Daisuke Tone, Koji L Ode, Qianhui Zhang, Hiroshi Fujishima, Rikuhiro G Yamada, Yoshiki Nagashima, Katsuhiko Matsumoto, Zhiqing Wen, Shota Y Yoshida, Tomoki T Mitani, Yuki Arisato, Rei-Ichiro Ohno, Maki Ukai-Tadenuma, Junko Yoshida Garçon, Mari Kaneko, Shoi Shi, Hideki Ukai, Kazunari Miyamichi, Takashi Okada, Kenta Sumiyama, Hiroshi Kiyonari, Hiroki R Ueda
The reduced sleep duration previously observed in Camk2b knockout mice revealed a role for Ca2+/calmodulin-dependent protein kinase II (CaMKII)β as a sleep-promoting kinase. However, the underlying mechanism by which CaMKIIβ supports sleep regulation is largely unknown. Here, we demonstrate that activation or inhibition of CaMKIIβ can increase or decrease sleep duration in mice by almost 2-fold, supporting the role of CaMKIIβ as a core sleep regulator in mammals. Importantly, we show that this sleep regulation depends on the kinase activity of CaMKIIβ...
October 2022: PLoS Biology
https://read.qxmd.com/read/36171316/author-correction-variability-measurements-provide-additional-value-to-shear-wave-elastography-in-the-diagnosis-of-pancreatic-cancer
#40
Masakatsu Yoshikawa, Takuya Ishikawa, Eizaburo Ohno, Tadashi Iida, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Masatoshi Ishigami, Fumie Kinoshita, Hiroki Kawashima, Mitsuhiro Fujishiro
No abstract text is available yet for this article.
September 28, 2022: Scientific Reports
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