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https://www.readbyqxmd.com/read/28048642/su-f-t-364-monte-carlo-dose-verification-of-volumetric-modulated-arc-therapy-plans-using-aapm-tg-119-test-patterns
#1
R Onizuka, F Araki, T Ohno, Y Nakaguchi
PURPOSE: To investigate the Monte Carlo (MC)-based dose verification for VMAT plans by a treatment planning system (TPS). METHODS: The AAPM TG-119 test structure set was used for VMAT plans by the Pinnacle3 (convolution/superposition), using a Synergy radiation head of a 6 MV beam with the Agility MLC. The Synergy was simulated with the EGSnrc/BEAMnrc code, and VMAT dose distributions were calculated with the EGSnrc/DOSXYZnrc code by the same irradiation conditions as TPS...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047778/su-f-t-541-impact-of-vmat-dose-calculations-with-respiratory-movements-in-lung
#2
K Komatsu, F Araki, T Ohno, Y Shimohigashi, R Onizuka
PURPOSE: To evaluate dose impact due to respiratory movements for volumetric modulated arc therapy (VMAT) in lung, using deformation technique. METHODS: The dose impact due to respiratory movements was evaluated for VMAT in lung. VMAT dose distributions were calculated with 4D-CT images for a 3-D dynamic lung phantom and seven patients. First, one-arc VMAT dose distributions were calculated at the reference phase (the maximum of expiratory phase) using the Varian Eclipse (ver...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047269/tu-h-campus-iep1-04-combined-organ-dose-for-digital-subtraction-angiography-and-computed-tomography-using-monte-carlo-simulation
#3
D Sakabe, T Ohno, F Araki, M Hashida, Y Funama
PURPOSE: The purpose of this study was to evaluate the combined organ dose of digital subtraction angiography (DSA) and computed tomography (CT) using a Monte Carlo (MC) simulation on the abdominal intervention. METHODS: The organ doses for DSA and CT were obtained with MC simulation and actual measurements using fluorescent-glass dosimeters at 7 abdominal portions in an Alderson-Rando phantom. DSA was performed from three directions: posterior anterior (PA), right anterior oblique (RAO), and left anterior oblique (LAO)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047041/su-f-t-549-validation-of-a-method-for-in-vivo-3d-dose-reconstruction-for-sbrt-using-a-new-transmission-detector
#4
Y Nakaguchi, Y Shimohigashi, R Onizuka, T Ohno
PURPOSE: Recently, there has been increased clinical use of stereotactic body radiation therapy (SBRT). SBRT treatments will strongly benefit from in vivo patient dose verification, as any errors in delivery can be more detrimental to the radiobiology of the patient as compared to conventional therapy. In vivo dose measurements, a commercially available quality assurance platform which is able to correlate the delivered dose to the patient's anatomy and take into account tissue inhomogeneity, is the COMPASS system (IBA Dosimetry, Germany) using a new transmission detector (Dolphin, IBA Dosimetry)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046952/su-f-t-630-energy-spectral-study-on-lipiodol-after-trans-arterial-chemoembolization-using-the-flattened-and-unflattened-photon-beams
#5
D Kawahara, S Ozawa, A Saito, T Nishio, K Hioki, H Masuda, T Okumura, Y Ochi, T Nakashima, T Suzuki, S Tanaka, Y Ohno, Y Nagata
PURPOSE: SBRT combining transarterial chemoembolization with Lipiodol is expected to improve local control. Our showed that the dose enhancement effect in the Lipiodol with 10X flattening filter free (FFF) was inserted. This study was to investigate the energy fluence variations of electron in the Lipiodol using flattened (FF) and FFF beams. METHODS: FF and FFF for 6X and 10X beams by TrueBeam were used in this study. The Lipiodol (3 X 3 X 3 cm(3) ) was located at the depth of 5 cm in water, the dose enhancement factor (DEF) and energy fluence were calculated by Monte Carlo (MC) calculations (PHITS)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27936958/kidney-resistive-index-relates-to-variations-of-home-blood-pressure-in-chronic-kidney-diseases
#6
Tsuneo Takenaka, Yoichi Ohno, Hiromichi Suzuki
BACKGROUND: Kidney resistive index (RI) correlates with tubulointerstitial changes and predicts renal prognosis. Most patients with chronic kidney diseases (CKDs) manifest high blood pressure and atherosclerotic cardiovascular diseases. In addition, various atherosclerotic indexes relate to variations in blood pressure. METHODS: Subjects were 70 CKD patients, who visited our office and agreed to measure home blood pressure and receive renal ultrasonography. Cross-sectional analyses were performed...
2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27927580/3rd-eso-esmo-international-consensus-guidelines-for-advanced-breast-cancer-abc-3
#7
F Cardoso, A Costa, E Senkus, M Aapro, F André, C H Barrios, J Bergh, G Bhattacharyya, L Biganzoli, M J Cardoso, L Carey, D Corneliussen-James, G Curigliano, V Dieras, N El Saghir, A Eniu, L Fallowfield, D Fenech, P Francis, K Gelmon, A Gennari, N Harbeck, C Hudis, B Kaufman, I Krop, M Mayer, H Meijer, S Mertz, S Ohno, O Pagani, E Papadopoulos, F Peccatori, F Pernault-Llorca, M J Piccart, J Y Pierga, H Rugo, L Shockney, G Sledge, S Swain, C Thomssen, A Tutt, D Vorobiof, B Xu, L Norton, E Winer
No abstract text is available yet for this article.
February 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27919884/3rd-eso-esmo-international-consensus-guidelines-for-advanced-breast-cancer-abc-3
#8
F Cardoso, A Costa, E Senkus, M Aapro, F André, C H Barrios, J Bergh, G Bhattacharyya, L Biganzoli, M J Cardoso, L Carey, D Corneliussen-James, G Curigliano, V Dieras, N El Saghir, A Eniu, L Fallowfield, D Fenech, P Francis, K Gelmon, A Gennari, N Harbeck, C Hudis, B Kaufman, I Krop, M Mayer, H Meijer, S Mertz, S Ohno, O Pagani, E Papadopoulos, F Peccatori, F Pernault-Llorca, M J Piccart, J Y Pierga, H Rugo, L Shockney, G Sledge, S Swain, C Thomssen, A Tutt, D Vorobiof, B Xu, L Norton, E Winer
No abstract text is available yet for this article.
December 5, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27805205/visible-luminescent-lanthanide-ions-and-a-large-%C3%AF-conjugated-ligand-system-shake-hands
#9
Y Kitagawa, R Ohno, T Nakanishi, K Fushimi, Y Hasegawa
Visible luminescence europium(iii) complexes with large π-conjugated systems were theoretically and experimentally studied. A strategy for extending the π-conjugation of a ligand for use with europium(iii) ions was found on the basis of fragment molecular orbital and density functional theory calculations. Using this method, a novel europium complex was designed and synthesized. Its excited state properties were assessed from the luminescence spectrum, excitation spectrum, luminescence lifetime, and luminescence quantum yield...
November 16, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27801474/hydrated-ionic-liquids-as-a-liquid-chaperon-for-refolding-of-aggregated-recombinant-protein-expressed-in-escherichia-coli
#10
K Fujita, M Kajiyama, Y Liu, N Nakamura, H Ohno
We have succeeded in refolding of aggregated recombinant protein from Escherichia coli in hydrated ionic liquids. In cholinium dihydrogen phosphate containing a limited amount of water molecules, aggregated solid cellulase was dissolved and refolding was successfully carried out without further processing.
November 1, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27675734/a-multi-institutional-analysis-of-prospective-studies-of-carbon-ion-radiation-therapy-for-prostate-cancer-an-analysis-of-2157-patients-from-the-japan-carbon-ion-radiation-oncology-study-group-j-cros
#11
T Nomiya, H Tsuji, H Kawamura, T Ohno, S Toyama, Y Shioyama, Y Nakayama, K Nemoto, H Tsujii, T Kamada
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675624/multi-institutional-study-of-carbon-ion-radiation-therapy-for-locally-advanced-pancreatic-cancer-japan-carbon-ion-radiation-oncology-study-group-j-cros-study-1403
#12
S Kawashiro, S Yamada, M Okamoto, T Ohno, T Nakano, M Shinoto, Y Shioyama, K Nemoto, D K Ebner, Y Isozaki, N Okada, H Tsuji, T Kamada
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675524/multi-institutional-retrospective-study-of-carbon-ion-radiation-therapy-for-stage-i-non-small-cell-lung-cancer-japan-carbon-ion-radiation-oncology-study-group
#13
Y Shioyama, N Yamamoto, J I Saitoh, O Fujii, A Matsunobu, T Ohno, T Okimoto, H Tsuji, T Kamada, T Nakano, K Nemoto
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675229/verification-of-mechanical-and-dosimetric-accuracy-for-head-and-neck-volumetric-modulated-arc-therapy-with-jaw-tracking
#14
T Okumura, T Nakashima, M Aita, Y Ochi, D Kawahara, H Masuda, K Hioki, Y Ohno, A Saito, Y Nagata
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674097/clinical-outcome-and-prognostic-factors-in-locally-advanced-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy-followed-by-surgery-and-postmastectomy-radiation-therapy
#15
N Nakajima, M Oguchi, Y Kumai, M Yoshida, T Iwase, Y Ito, F Akiyama, S Ohno
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27667193/satellite-rnas-promote-pancreatic-oncogenic-processes-via-the-dysfunction-of-ybx1
#16
Takahiro Kishikawa, Motoyuki Otsuka, Takeshi Yoshikawa, Motoko Ohno, Hideaki Ijichi, Kazuhiko Koike
Highly repetitive tandem arrays at the centromeric and pericentromeric regions in chromosomes, previously considered silent, are actively transcribed, particularly in cancer. This aberrant expression occurs even in K-ras-mutated pancreatic intraepithelial neoplasia (PanIN) tissues, which are precancerous lesions. To examine the biological roles of the satellite RNAs in carcinogenesis, we construct mouse PanIN-derived cells expressing major satellite (MajSAT) RNA and show increased malignant properties. We find an increase in frequency of chromosomal instability and point mutations in both genomic and mitochondrial DNA...
2016: Nature Communications
https://www.readbyqxmd.com/read/27609682/transcatheter-aortic-valve-replacement-with-early-and-new-generation-devices-in-bicuspid-aortic-valve-stenosis
#17
Sung-Han Yoon, Thierry Lefèvre, Jung-Ming Ahn, Gidon Y Perlman, Danny Dvir, Azeem Latib, Marco Barbanti, Florian Deuschl, Ole De Backer, Philipp Blanke, Thomas Modine, Gregor Pache, Franz-Josef Neumann, Philipp Ruile, Takahide Arai, Yohei Ohno, Hidehiro Kaneko, Edgar Tay, Niklas Schofer, Erik W Holy, Ngai H V Luk, Gerald Yong, Qingsheng Lu, William K F Kong, Jimmy Hon, Hsien-Li Kao, Michael Lee, Wei-Hsian Yin, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Hyo-Soo Kim, Christian Butter, Omar K Khalique, Ulrich Schaefer, Fabian Nietlispach, Susheel K Kodali, Martin B Leon, Jian Ye, Bernard Chevalier, Jonathon Leipsic, Victoria Delgado, Jeroen J Bax, Corrado Tamburino, Antonio Colombo, Lars Søndergaard, John G Webb, Seung-Jung Park
BACKGROUND: Few studies have evaluated the clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve stenosis (AS). Particularly, limited data exist comparing the results of TAVR with new-generation devices versus early-generation devices. OBJECTIVES: This study sought to evaluate the clinical outcomes of TAVR for bicuspid AS with early- and new-generation devices. METHODS: The Bicuspid TAVR Registry is an international multicenter study enrolling consecutive patients with bicuspid AS undergoing TAVR between April 2005 and May 2015...
September 13, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27593371/the-x-to-autosome-expression-ratio-in-haploid-and-diploid-human-embryonic-stem-cells
#18
LETTER
Xiaoshu Chen, Jianzhi Zhang
Ohno proposed that the expression levels of X-linked genes have been doubled to compensate the degeneration of Y-linked homologs during the evolution of mammalian sex chromosomes, but RNA sequencing in human somatic tissues showed no such upregulation for the vast majority of X-linked genes. Here we report that the X to autosome expression ratio equals ∼1 in haploid human parthenogenetic embryonic stem (pES) cells and ∼0.5 in diploidized pES cells, both with one active X chromosome. Although we confirmed the upregulation of ∼5% of X-linked genes encoding members of large protein complexes in diploids, these genes are also upregulated in haploids, breaking the otherwise balanced dosage...
December 2016: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/27452199/catecholaminergic-polymorphic-ventricular-tachycardia-cpvt-associated-with-ryanodine-receptor-ryr2-gene-mutations%C3%A3-long-term-prognosis-after-initiation-of-medical-treatment
#19
Hiro Kawata, Seiko Ohno, Takeshi Aiba, Heima Sakaguchi, Aya Miyazaki, Naokata Sumitomo, Tsukasa Kamakura, Ikutaro Nakajima, Yuko Y Inoue, Koji Miyamoto, Hideo Okamura, Takashi Noda, Kengo Kusano, Shiro Kamakura, Yoshihiro Miyamoto, Isao Shiraishi, Minoru Horie, Wataru Shimizu
BACKGROUND: The long-term prognosis of cardiac ryanodine receptor (RyR2) positive catecholaminergic polymorphic ventricular tachycardia (CPVT) patients after initiation of medical therapy has not been well investigated. This study aimed to assess the recurrence of fatal cardiac event after initiation of medical therapy inRyR2-positive CPVT patients. METHODS AND RESULTS: Thirty-fourRyR2-positive CPVT patients with a history of cardiac events were enrolled. All patients had medical treatment initiated after the first symptom or diagnosis...
August 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27365323/orbital-fat-volumetry-and-water-fraction-measurements-using-t2-weighted-fse-ideal-imaging-in-patients-with-thyroid-associated-orbitopathy
#20
Y Kaichi, K Tanitame, H Itakura, H Ohno, M Yoneda, Y Takahashi, Y Akiyama, K Awai
BACKGROUND AND PURPOSE: The quantitative evaluation of orbital fat proliferation and edema and the assessment of extraocular muscles are useful for diagnosing and monitoring thyroid-associated orbitopathy. To evaluate therapy-induced quantitative changes in the orbital fat of patients with thyroid-associated orbitopathy, we performed volumetric and water fraction measurements by using T2-weighted FSE iterative decomposition of water and fat with echo asymmetry and least-squares estimation (FSE-IDEAL) imaging...
June 30, 2016: AJNR. American Journal of Neuroradiology
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