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https://www.readbyqxmd.com/read/27927580/3rd-eso-esmo-international-consensus-guidelines-for-advanced-breast-cancer-abc-3
#1
F Cardoso, A Costa, E Senkus, M Aapro, F André, C H Barrios, J Bergh, G Bhattacharyya, L Biganzoli, M J Cardoso, L Carey, D Corneliussen-James, G Curigliano, V Dieras, N El Saghir, A Eniu, L Fallowfield, D Fenech, P Francis, K Gelmon, A Gennari, N Harbeck, C Hudis, B Kaufman, I Krop, M Mayer, H Meijer, S Mertz, S Ohno, O Pagani, E Papadopoulos, F Peccatori, F Pernault-Llorca, M J Piccart, J Y Pierga, H Rugo, L Shockney, G Sledge, S Swain, C Thomssen, A Tutt, D Vorobiof, B Xu, L Norton, E Winer
No abstract text is available yet for this article.
December 1, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27919884/3rd-eso-esmo-international-consensus-guidelines-for-advanced-breast-cancer-abc-3
#2
F Cardoso, A Costa, E Senkus, M Aapro, F André, C H Barrios, J Bergh, G Bhattacharyya, L Biganzoli, M J Cardoso, L Carey, D Corneliussen-James, G Curigliano, V Dieras, N El Saghir, A Eniu, L Fallowfield, D Fenech, P Francis, K Gelmon, A Gennari, N Harbeck, C Hudis, B Kaufman, I Krop, M Mayer, H Meijer, S Mertz, S Ohno, O Pagani, E Papadopoulos, F Peccatori, F Pernault-Llorca, M J Piccart, J Y Pierga, H Rugo, L Shockney, G Sledge, S Swain, C Thomssen, A Tutt, D Vorobiof, B Xu, L Norton, E Winer
No abstract text is available yet for this article.
December 5, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27805205/visible-luminescent-lanthanide-ions-and-a-large-%C3%AF-conjugated-ligand-system-shake-hands
#3
Y Kitagawa, R Ohno, T Nakanishi, K Fushimi, Y Hasegawa
Visible luminescence europium(iii) complexes with large π-conjugated systems were theoretically and experimentally studied. A strategy for extending the π-conjugation of a ligand for use with europium(iii) ions was found on the basis of fragment molecular orbital and density functional theory calculations. Using this method, a novel europium complex was designed and synthesized. Its excited state properties were assessed from the luminescence spectrum, excitation spectrum, luminescence lifetime, and luminescence quantum yield...
November 16, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27801474/hydrated-ionic-liquids-as-a-liquid-chaperon-for-refolding-of-aggregated-recombinant-protein-expressed-in-escherichia-coli
#4
K Fujita, M Kajiyama, Y Liu, N Nakamura, H Ohno
We have succeeded in refolding of aggregated recombinant protein from Escherichia coli in hydrated ionic liquids. In cholinium dihydrogen phosphate containing a limited amount of water molecules, aggregated solid cellulase was dissolved and refolding was successfully carried out without further processing.
November 1, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27675734/a-multi-institutional-analysis-of-prospective-studies-of-carbon-ion-radiation-therapy-for-prostate-cancer-an-analysis-of-2157-patients-from-the-japan-carbon-ion-radiation-oncology-study-group-j-cros
#5
T Nomiya, H Tsuji, H Kawamura, T Ohno, S Toyama, Y Shioyama, Y Nakayama, K Nemoto, H Tsujii, T Kamada
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675624/multi-institutional-study-of-carbon-ion-radiation-therapy-for-locally-advanced-pancreatic-cancer-japan-carbon-ion-radiation-oncology-study-group-j-cros-study-1403
#6
S Kawashiro, S Yamada, M Okamoto, T Ohno, T Nakano, M Shinoto, Y Shioyama, K Nemoto, D K Ebner, Y Isozaki, N Okada, H Tsuji, T Kamada
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675524/multi-institutional-retrospective-study-of-carbon-ion-radiation-therapy-for-stage-i-non-small-cell-lung-cancer-japan-carbon-ion-radiation-oncology-study-group
#7
Y Shioyama, N Yamamoto, J I Saitoh, O Fujii, A Matsunobu, T Ohno, T Okimoto, H Tsuji, T Kamada, T Nakano, K Nemoto
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675229/verification-of-mechanical-and-dosimetric-accuracy-for-head-and-neck-volumetric-modulated-arc-therapy-with-jaw-tracking
#8
T Okumura, T Nakashima, M Aita, Y Ochi, D Kawahara, H Masuda, K Hioki, Y Ohno, A Saito, Y Nagata
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674097/clinical-outcome-and-prognostic-factors-in-locally-advanced-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy-followed-by-surgery-and-postmastectomy-radiation-therapy
#9
N Nakajima, M Oguchi, Y Kumai, M Yoshida, T Iwase, Y Ito, F Akiyama, S Ohno
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27667193/satellite-rnas-promote-pancreatic-oncogenic-processes-via-the-dysfunction-of-ybx1
#10
Takahiro Kishikawa, Motoyuki Otsuka, Takeshi Yoshikawa, Motoko Ohno, Hideaki Ijichi, Kazuhiko Koike
Highly repetitive tandem arrays at the centromeric and pericentromeric regions in chromosomes, previously considered silent, are actively transcribed, particularly in cancer. This aberrant expression occurs even in K-ras-mutated pancreatic intraepithelial neoplasia (PanIN) tissues, which are precancerous lesions. To examine the biological roles of the satellite RNAs in carcinogenesis, we construct mouse PanIN-derived cells expressing major satellite (MajSAT) RNA and show increased malignant properties. We find an increase in frequency of chromosomal instability and point mutations in both genomic and mitochondrial DNA...
2016: Nature Communications
https://www.readbyqxmd.com/read/27609682/transcatheter-aortic-valve-replacement-with-early-and-new-generation-devices-in-bicuspid-aortic-valve-stenosis
#11
Sung-Han Yoon, Thierry Lefèvre, Jung-Ming Ahn, Gidon Y Perlman, Danny Dvir, Azeem Latib, Marco Barbanti, Florian Deuschl, Ole De Backer, Philipp Blanke, Thomas Modine, Gregor Pache, Franz-Josef Neumann, Philipp Ruile, Takahide Arai, Yohei Ohno, Hidehiro Kaneko, Edgar Tay, Niklas Schofer, Erik W Holy, Ngai H V Luk, Gerald Yong, Qingsheng Lu, William K F Kong, Jimmy Hon, Hsien-Li Kao, Michael Lee, Wei-Hsian Yin, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Hyo-Soo Kim, Christian Butter, Omar K Khalique, Ulrich Schaefer, Fabian Nietlispach, Susheel K Kodali, Martin B Leon, Jian Ye, Bernard Chevalier, Jonathon Leipsic, Victoria Delgado, Jeroen J Bax, Corrado Tamburino, Antonio Colombo, Lars Søndergaard, John G Webb, Seung-Jung Park
BACKGROUND: Few studies have evaluated the clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve stenosis (AS). Particularly, limited data exist comparing the results of TAVR with new-generation devices versus early-generation devices. OBJECTIVES: This study sought to evaluate the clinical outcomes of TAVR for bicuspid AS with early- and new-generation devices. METHODS: The Bicuspid TAVR Registry is an international multicenter study enrolling consecutive patients with bicuspid AS undergoing TAVR between April 2005 and May 2015...
September 13, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27593371/the-x-to-autosome-expression-ratio-in-haploid-and-diploid-human-embryonic-stem-cells
#12
LETTER
Xiaoshu Chen, Jianzhi Zhang
Ohno proposed that the expression levels of X-linked genes have been doubled to compensate the degeneration of Y-linked homologs during the evolution of mammalian sex chromosomes, but RNA sequencing in human somatic tissues showed no such upregulation for the vast majority of X-linked genes. Here we report that the X to autosome expression ratio equals ∼1 in haploid human parthenogenetic embryonic stem (pES) cells and ∼0.5 in diploidized pES cells, both with one active X chromosome. Although we confirmed the upregulation of ∼5% of X-linked genes encoding members of large protein complexes in diploids, these genes are also upregulated in haploids, breaking the otherwise balanced dosage...
December 2016: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/27452199/catecholaminergic-polymorphic-ventricular-tachycardia-cpvt-associated-with-ryanodine-receptor-ryr2-gene-mutations%C3%A3-long-term-prognosis-after-initiation-of-medical-treatment
#13
Hiro Kawata, Seiko Ohno, Takeshi Aiba, Heima Sakaguchi, Aya Miyazaki, Naokata Sumitomo, Tsukasa Kamakura, Ikutaro Nakajima, Yuko Y Inoue, Koji Miyamoto, Hideo Okamura, Takashi Noda, Kengo Kusano, Shiro Kamakura, Yoshihiro Miyamoto, Isao Shiraishi, Minoru Horie, Wataru Shimizu
BACKGROUND: The long-term prognosis of cardiac ryanodine receptor (RyR2) positive catecholaminergic polymorphic ventricular tachycardia (CPVT) patients after initiation of medical therapy has not been well investigated. This study aimed to assess the recurrence of fatal cardiac event after initiation of medical therapy inRyR2-positive CPVT patients. METHODS AND RESULTS: Thirty-fourRyR2-positive CPVT patients with a history of cardiac events were enrolled. All patients had medical treatment initiated after the first symptom or diagnosis...
August 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27365323/orbital-fat-volumetry-and-water-fraction-measurements-using-t2-weighted-fse-ideal-imaging-in-patients-with-thyroid-associated-orbitopathy
#14
Y Kaichi, K Tanitame, H Itakura, H Ohno, M Yoneda, Y Takahashi, Y Akiyama, K Awai
BACKGROUND AND PURPOSE: The quantitative evaluation of orbital fat proliferation and edema and the assessment of extraocular muscles are useful for diagnosing and monitoring thyroid-associated orbitopathy. To evaluate therapy-induced quantitative changes in the orbital fat of patients with thyroid-associated orbitopathy, we performed volumetric and water fraction measurements by using T2-weighted FSE iterative decomposition of water and fat with echo asymmetry and least-squares estimation (FSE-IDEAL) imaging...
June 30, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27284001/transient-receptor-potential-ankyrin-1-agonists-improve-intestinal-transit-in-a-murine-model-of-postoperative-ileus
#15
K Tsuchiya, K Kubota, K Ohbuchi, A Kaneko, N Ohno, A Mase, H Matsushima, M Yamamoto, K Miyano, Y Uezono, T Kono
BACKGROUND: Stimulation of transient receptor potential ankyrin 1 (TRPA1), which abundantly expressed in enterochromaffin cells (ECC), has been reported to exert apparently contradictory results in in vitro contractility and in vivo gastrointestinal (GI) transit evaluations. The pharmaceutical-grade Japanese traditional medicine daikenchuto (TU-100) has been reported to be beneficial for postoperative ileus (POI) and accelerate GI transit in animals and humans. TU-100 was recently shown to increase intestinal blood flow via stimulation of TRPA1 in the epithelial cells of the small intestine (SI)...
June 10, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27270597/ranibizumab-in-myopic-choroidal-neovascularization-a-subgroup-analysis-by-ethnicity-age-and-ocular-characteristics-in-radiance
#16
Frank G Holz, Adnan Tufail, Nicolas Leveziel, Timothy Y Y Lai, Paolo Lanzetta, Tien Y Wong, Hyeong Gon Yu, You Xin Chen, Nikol Heinrichs, Stefan Pilz, Kyoko Ohno-Matsui
PURPOSE: To assess the impact of ethnicity, age, and ocular characteristics on ranibizumab efficacy in myopic choroidal neovascularization (CNV). METHODS: In this post hoc subgroup analysis from the phase III RADIANCE study, best-corrected visual acuity (BCVA) outcomes and treatment exposure were analyzed in 105 patients treated with ranibizumab 0.5 mg. Baseline categories included ethnicity, age, baseline BCVA, lesion area, CNV lesion area, refraction sphere, axial length, subretinal fluid, and location of CNV...
2016: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/27052670/optogenetic-activation-of-axon-guidance-receptors-controls-direction-of-neurite-outgrowth
#17
M Endo, M Hattori, H Toriyabe, H Ohno, H Kamiguchi, Y Iino, T Ozawa
Growth cones of extending axons navigate to correct targets by sensing a guidance cue gradient via membrane protein receptors. Although most signaling mechanisms have been clarified using an in vitro approach, it is still difficult to investigate the growth cone behavior in complicated extracellular environment of living animals due to the lack of tools. We develop a system for the light-dependent activation of a guidance receptor, Deleted in Colorectal Cancer (DCC), using Arabidopsis thaliana Cryptochrome 2, which oligomerizes upon blue-light absorption...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27005806/feasibility-study-of-axillary-reverse-mapping-for-patients-with-clinically-node-negative-breast-cancer
#18
M Noguchi, M Noguchi, Y Ohno, E Morioka, Y Nakano, T Kosaka, N Kurose, H Minato
BACKGROUND: The axillary reverse mapping (ARM) procedure was developed to identify and preserve arm lymphatic drainage during axillary lymph node dissection (ALND), thereby theoretically reducing the incidence of arm lymphedema. However, the oncological safety of this procedure has not yet been determined. METHODS: Two hundred ninety-two patients with clinically negative nodes (cN0) underwent both sentinel lymph node (SLN) biopsy and ARM. SLN was identified by dye and gamma probe methods, and ARM nodes were identified using a fluorescence imaging system...
May 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26999481/a-spin-orbit-torque-switching-scheme-with-collinear-magnetic-easy-axis-and-current-configuration
#19
S Fukami, T Anekawa, C Zhang, H Ohno
Spin-orbit torque, a torque brought about by in-plane current via the spin-orbit interactions in heavy-metal/ferromagnet nanostructures, provides a new pathway to switch the magnetization direction. Although there are many recent studies, they all build on one of two structures that have the easy axis of a nanomagnet lying orthogonal to the current, that is, along the z or y axes. Here, we present a new structure with the third geometry, that is, with the easy axis collinear with the current (along the x axis)...
July 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/26988623/oncoplastic-breast-conserving-surgery-volume-replacement-vs-volume-displacement
#20
REVIEW
M Noguchi, M Yokoi-Noguchi, Y Ohno, E Morioka, Y Nakano, T Kosaka, T Kurita
Oncoplastic breast conserving surgery (BCS) has emerged as a third option between conventional BCS and mastectomy. Oncoplastic BCS includes two fundamentally different approaches: volume replacement and volume displacement. The former involves partial mastectomy and immediate reconstruction of the breast with the transposition of autologous tissue from elsewhere, while the latter involves partial mastectomy and using the remaining breast tissue to fill the defect resulting from extirpation of the tumor. There are several benefits associated with oncoplastic BCS...
July 2016: European Journal of Surgical Oncology
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