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JOURNAL ARTICLE
Amor Khachemoune, Hui Yu Juan, Rohan Singh
Cutaneous squamous cell carcinoma can arise from various premalignant lesions such as actinic keratosis, Bowen disease, and premalignant genital squamous cell lesions. Identification and treatment can prevent malignant transformation and death. This article describes the causes, epidemiology, and characteristics of suspicious premalignant squamous cell lesions so that clinicians can identify these lesions and refer patients for specialist treatment as appropriate.
January 1, 2024: JAAPA: Official Journal of the American Academy of Physician Assistants
#22
JOURNAL ARTICLE
Daniel Piacquadio, Brian Berman, Daniel M Siegel, Neal Bhatia, Jason Brocato, Nicholas Squittieri, David M Pariser
BACKGROUND: Actinic keratoses (AKs) are precancerous, dysplastic, epidermal lesions caused by chronic sun exposure that may progress to squamous cell carcinoma. Aminolevulinic acid 20% solution with blue light photodynamic therapy (ALA-PDT) has previously been shown to be superior to vehicle plus PDT (VEH-PDT) for treatment of AKs of the face, scalp, and upper extremities. OBJECTIVE: We report detailed patient satisfaction data for ALA-PDT. METHODS: Patient satisfaction for ALA-PDT versus VEH-PDT and patient-reported acceptability of ALA-PDT versus previous treatments for AKs were assessed in three randomized, vehicle-controlled studies (two Phase II and one Phase III) in adults...
December 2023: Journal of Clinical and Aesthetic Dermatology
#23
Komal A Paradkar, Alisha N Plotner
Keratoacanthoma (KA) is an epidermal cell tumor with a central keratin plug known to be a variant of keratinocyte carcinoma (KC). KAs typically arise from ultraviolet (UV)-damaged skin and thus are particularly prevalent on extremities. KAs can also be a consequence of local skin trauma. 5-fluorouracil (5-FU) is a topical therapy used to treat early KC, as well as actinic keratoses (AKs). In this paper, we describe the unique cases of two elderly female patients who were treated with 5-FU for AKs of the lower extremities but developed severe inflammatory reactions and reactive KAs to the topical therapy...
December 2023: Journal of Clinical and Aesthetic Dermatology
#24
JOURNAL ARTICLE
G Pellacani, T Schlesinger, N Bhatia, B Berman, M Lebwohl, J L Cohen, G K Patel, R Kunstfeld, I Hadshiew, J T Lear
BACKGROUND: The 31st European Academy of Dermatology and Venereology (EADV) Congress took place between 7th and 10th of September 2022 in Milan, Italy. OBJECTIVES: We report presented clinical data on the efficacy/effectiveness, safety and tolerability of tirbanibulin 1% ointment that has recently been licensed for actinic keratosis (AK) of the face or scalp in adults. METHODS: Summary of presentations given at the EADV Congress. RESULTS: Prof...
January 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#25
JOURNAL ARTICLE
Stefano Caccavale, Maria Pia Boccellino, Gabriella Brancaccio, Roberto Alfano, Giuseppe Argenziano
BACKGROUND: Methyl aminolevulinate (MAL) photodynamic therapy (PDT) is commonly used for field treatment of actinic keratoses (AKs). In standard natural daylight PDT (n-DL-PDT) the first step, after the application of chemical solar filter, is removal of crusts and scales by curettage, followed by the application of MAL cream. Some patients experience intense pain during curettage and stinging after application of the photosensitizer to just curettaged skin. OBJECTIVES: To evaluate whether n-DL-PDT without curettage, but preceded by application of keratolytics, would maintain a similar efficacy, based on clinical, dermoscopic, reflectance confocal microscopy (RCM) assessments, safety and patient satisfaction as standard n-DL-PDT with curettage...
December 10, 2023: Journal of the European Academy of Dermatology and Venereology: JEADV
#26
JOURNAL ARTICLE
Emi Dika, Emi Dika, Martina Lambertini, Emi Dika, Martina Lambertini, Giulia Veronesi, Cosimo Misciali, Massimo Milani, Aleksandra Bergant-Suhodolcan, Bor Hrvatin Stancic, Carlotta Baraldi
Dear Editor, Actinic keratoses (AK) have a high prevalence in the general population, with greater rates in Caucasian patients after the fourth and fifth decades of life (37.5-60.0%) (1,2). Standard histopathologic reporting of AKs does not provide information on the presence of atypical keratinocytes extending to the hair follicle, also defined as folliculotropism (FLC). Commonly, atypical cells in AKs do not present FLC, but this feature can be observed in bowenoid AKs with full-thickness epidermal atypia (3,4)...
November 2023: Acta Dermatovenerologica Croatica: ADC
#27
REVIEW
Katerina Bakirtzi, Ilias Papadimitriou, Efstratios Vakirlis, Aimilios Lallas, Eleni Sotiriou
INTRODUCTION: Photodynamic therapy (PDT) with a photosensitizer is available for the treatment of multiple actinic keratoses (AKs) in a restricted skin area or, as it is established, for the field-cancerized skin. OBJECTIVES: Our review aims to present the up-to-date literature on skin field cancerization using PDT employing different topical photosensitizers, modified light delivery protocols and combination treatments to obtain excellent efficacy and safety in everyday clinical practice...
October 1, 2023: Dermatology Practical & Conceptual
#28
REVIEW
Cara Symanzik, Swen Malte John
Due to their professional activities, outdoor workers are exposed to an increased risk of developing occupational skin cancer caused by solar ultraviolet (UV) radiation as defined by occupational disease (OD) number 5103. Since the amendment to the Occupational Diseases Ordinance ("Berufskrankheitenverordnung", BKV) in 2015, squamous cell carcinomas or multiple actinic keratoses of the skin caused by natural UV radiation in outdoor workers in Germany can be recognized as occupational disease in the sense of OD number 5103...
November 14, 2023: Dermatologie (Heidelb)
#29
Elena González-Guerra, Alberto Conde Taboada, Lucia Campos Muñoz, Ana Isabel Sánchez Fructuoso
Continuous immunosuppression after organ transplantation is associated with an increased risk of developing keratinocyte neoplastic lesions. Topical photodynamic therapy represents a therapeutic approach for different keratinocyte neoplastic lesions. However, the specific efficacy and safety of this treatment in this immunocompromised population remains largely unknown. In this case report series, we show the efficacy and safety of photodynamic therapy with BF-200 ALA gel using red-light and daylight in immunocompromised patients...
November 8, 2023: Photodiagnosis and Photodynamic Therapy
#30
JOURNAL ARTICLE
Ulrike Leiter, Markus V Heppt, Theresa Steeb, Mareike Alter, Teresa Amaral, Andrea Bauer, Falk G Bechara, Jürgen C Becker, Eckhard W Breitbart, Helmut Breuninger, Thomas Diepgen, Thomas Dirschka, Thomas Eigentler, A K Stephan El Gammal, Moritz Felcht, Michael J Flaig, Markus Follmann, Klaus Fritz, Stephan Grabbe, Rüdiger Greinert, Ralf Gutzmer, Axel Hauschild, Uwe Hillen, Stephan Ihrler, Swen Malte John, Lukas Kofler, Oliver Koelbl, Albrecht Krause-Bergmann, Klaus Kraywinkel, Steffen Krohn, Thomas Langer, Carmen Loquai, Christoph R Löser, Peter Mohr, Dorothée Nashan, Monika Nothacker, Christina Pfannenberg, Carmen Salavastru, Lutz Schmitz, Eggert Stockfleth, Rolf-Markus Szeimies, Claas Ulrich, Susanne Voelter-Mahlknecht, Dirk Vordermark, Michael Weichenthal, Julia Welzel, Kai Wermker, Susanne Wiegand, Claus Garbe, Carola Berking
No abstract text is available yet for this article.
November 2023: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
#31
JOURNAL ARTICLE
Khalifa Sharquie, Raed I Jabbar, Robert A Schwartz, Muriel W Lambert, W Clark Lambert
Xeroderma pigmentosum (XP) is a rare autosomal recessive disease; relatively mild XP patients are sometimes designated as having pigmented xerodermoid or xerodermoid pigmentosum (XP-V), a variant of XP. It is commonly associated with many long-standing skin conditions and tumors, including malignancies, management of which is necessary to prevent the progress of the disease. The objective of the study was to report the use of a number of innovative therapeutic and prophylactic treatments, beyond surgery, such as topical 5-fluorouracil, topical imiquimod, other topical immunomodulators, or photodynamic therapy, in treating skin eruptions and their complications in XP patients...
2023: Skinmed
#32
JOURNAL ARTICLE
Markus V Heppt, Ulrike Leiter, Theresa Steeb, Mareike Alter, Teresa Amaral, Andrea Bauer, Falk G Bechara, Jürgen C Becker, Eckhard W Breitbart, Helmut Breuninger, Thomas Diepgen, Thomas Dirschka, Thomas Eigentler, A K Stephan El Gammal, Moritz Felcht, Michael J Flaig, Markus Follmann, Klaus Fritz, Stephan Grabbe, Rüdiger Greinert, Ralf Gutzmer, Axel Hauschild, Uwe Hillen, Stephan Ihrler, Swen Malte John, Lukas Kofler, Oliver Koelbl, Albrecht Krause-Bergmann, Klaus Kraywinkel, Steffen Krohn, Thomas Langer, Carmen Loquai, Christoph R Löser, Peter Mohr, Dorothée Nashan, Monika Nothacker, Christina Pfannenberg, Carmen Salavastru, Lutz Schmitz, Eggert Stockfleth, Rolf-Markus Szeimies, Claas Ulrich, Susanne Voelter-Mahlknecht, Dirk Vordermark, Michael Weichenthal, Julia Welzel, Kai Wermker, Susanne Wiegand, Claus Garbe, Carola Berking
No abstract text is available yet for this article.
October 2023: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
#33
JOURNAL ARTICLE
Alan S Shen, Lauren E Heusinkveld, Abigail Updyke, Amy S Nowacki, Christine B Warren, Edward V Maytin
INTRODUCTION: Photodynamic therapy (PDT) is a safe, non-mutagenic, and non-scarring treatment for actinic keratoses (AK). BACKGROUND: 'Painless' photodynamic therapy (p-PDT) is a regimen for AK that employs simultaneous aminolevulinate incubation and blue light illumination. The efficacy of p-PDT resembles that of traditional PDT, but detailed mechanisms of action for p-PDT are not well understood. METHODS: To characterize the inflammatory effects of the p-PDT procedure 48 hours following treatment and determine the association of inflammation with precancer burden, we performed a retrospective cohort study of 104 patients with AK of face or scalp treated with p-PDT between 2017 and 2019...
October 14, 2023: Photodiagnosis and Photodynamic Therapy
#34
REVIEW
R-M Szeimies, H Stege
Actinic keratoses (AKs) are common precancerous skin lesions that primarily affect older adults due to cumulative sun exposure. Given the increased vulnerability of older adults to developing AKs, appropriate therapeutic strategies are crucial to prevent their progression to invasive squamous cell carcinoma. This comprehensive review aims to explore the various treatment modalities available for AKs in the elderly population, focusing on their efficacy, safety, and suitability for this specific age group. The article discusses topical treatments, cryotherapy, photodynamic therapy, chemical peels, and surgical interventions, providing a detailed analysis of their mechanisms of action, benefits, limitations, and considerations in geriatric patients...
August 18, 2023: Dermatologie (Heidelb)
#35
REVIEW
Riya T Patel, Jane J Gay, Kiley K Fagan, Joshua D Eikenberg
Calcipotriol (calcipotriene) is a synthetic vitamin D3 derivative that is a standard treatment option for psoriasis. It is generally well tolerated with minimal side effects. Due to its ability to reduce keratinocyte proliferation and induce keratinocyte differentiation as well as its immunomodulatory effects, calcipotriol has been used to treat a variety of skin disorders such as atopic dermatitis, actinic keratoses, lichen planus, seborrheic keratoses, and vitiligo [1]. We surveyed the literature examining the use of calcipotriol for non-psoriatic dermatologic disease...
June 15, 2023: Dermatology Online Journal
#36
JOURNAL ARTICLE
Vivian Lindholm, Mari Salmivuori, Sonja Hahtola, Kerttu Mäkelä, Sari Pitkänen, Kirsi Isoherranen
Artificial daylight photodynamic therapy is a near-painless treatment for actinic keratoses, which can be performed indoors using a controlled light dose. Daylight photodynamic therapy is approved only for treatment of grade I-II actinic keratoses. The aim of this study was to evaluate whether fractional laser pre-treatment improves the outcomes of daylight photodynamic therapy for actinic keratoses of all grades. In addition, the study compared the outcomes of artificial and natural daylight photodynamic therapy...
August 16, 2023: Acta Dermato-venereologica
#37
JOURNAL ARTICLE
Alberto J Ruiz, Ethan P M LaRochelle, Marie-Christine P Fahrner, Jennifer A Emond, Kimberley S Samkoe, Brian W Pogue, M Shane Chapman
BACKGROUND: Photodynamic therapy (PDT) is widely used as a treatment for actinic keratoses (AK), with new sunlight-based regimens proposed as alternatives to lamp-based treatments. Prescribing indoor daylight activation could help address the seasonal temperature, clinical supervision, and access variability associated with outdoor treatments. OBJECTIVE: To compare the AK lesion clearance efficacy of indoor daylight PDT treatment (30 min of 5-aminolevulinic acid (ALA) pre-incubation, followed by 2 h of indoor sunlight) versus a lamp-based PDT treatment (30 min of ALA preincubation, followed by 10 min of red light)...
August 2023: Skin Health Dis
#38
JOURNAL ARTICLE
Zachary A Bordeaux, Justin Choi, Gabriella Braun, Cole Davis, Melika Marani, Kevin Lee, Christeen Samuel, Jackson Adams, Reed Windom, Anthony Pollizzi, Anusha Kambala, Hannah Cornman, Sriya V Reddy, Weiying Lu, Olusola O Oladipo, Martin P Alphonse, Cameron E West, Shawn G Kwatra, Madan M Kwatra
Actinic keratoses (AKs) are premalignant intraepidermal neoplasms that occur as a result of cumulative sun damage. AKs commonly relapse, and up to 16% undergo malignant transformation into cutaneous squamous cell carcinoma. There is a need for novel therapies that reduce the quantity and surface area of AKs as well as prevent malignant transformation to cutaneous squamous cell carcinomas. We recently showed that GZ17-6.02, an anticancer agent composed of curcumin, haramine, and isovanillin, inhibited the growth of H297...
July 2023: JID innovations
#39
REVIEW
Celina Pihl, Catharina M Lerche, Flemming Andersen, Peter Bjerring, Merete Haedersdal
BACKGROUND: Photodynamic therapy (PDT) is approved for treatment of actinic keratoses (AKs) and field-cancerisation. Pretreatment with pharmacological compounds holds potential to improve PDT efficacy, through direct interaction with PpIX formation or through an independent response, both of which may improve PDT treatment. OBJECTIVE: To present the currently available clinical evidence of pharmacological pretreatments prior to PDT and to associate potential clinical benefits with the pharmacological mechanisms of action of the individual compounds...
July 8, 2023: Photodiagnosis and Photodynamic Therapy
#40
JOURNAL ARTICLE
Shiyang Li, Chengquan Li, Qicai Liu, Yilin Pei, Liyang Wang, Zhu Shen
Actinic keratosis (AK) is a common precancerous skin lesion with significant harm, and it is often confused with non-actinic keratoses (NAK). At present, the diagnosis of AK mainly depends on clinical experience and histopathology. Due to the high difficulty of diagnosis and easy confusion with other diseases, this article aims to develop a convolutional neural network that can efficiently, accurately, and automatically diagnose AK. This article improves the MobileNet model and uses the AK and NAK images in the HAM10000 dataset for training and testing after data preprocessing, and we performed external independent testing using a separate dataset to validate our preprocessing approach and to demonstrate the performance and generalization capability of our model...
June 19, 2023: Bioengineering
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