keyword
MENU ▼
Read by QxMD icon Read
search

actinic keratoses treatment

keyword
https://www.readbyqxmd.com/read/29753305/a-prospective-randomised-within-subject-study-of-ala-pdt-for-actinic-keratoses-using-different-irradiation-regimes
#1
O Zaar, A Sjöholm Hylén, M Gillstedt, J Paoli
BACKGROUND: Photodynamic therapy (PDT) can be used to treat large fields of actinic keratoses (AKs) with high clearance rates. A notable downside is the amount of pain that accompany the treatment. This study aimed to optimise the illumination protocol during conventional PDT in order to reduce pain without compromising treatment effectiveness. METHODS: In this prospective, randomised study with a split-face design, patients with, symmetrically distributed AKs were included...
May 12, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29752702/daylight-photodynamic-therapy-for-actinic-keratoses
#2
REVIEW
Colin A Morton, Lasse R Braathen
Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, but with minimal therapy-associated pain. Comparison with conventional PDT indicates similar efficacy for thin and moderate-thickness AKs, but with significantly less discomfort/pain, driving a patient preference for daylight-mediated PDT (DL-PDT) compared with conventional PDT using high-intensity office/hospital-based light sources...
May 11, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29696353/-early-detection-of-occupational-skin-diseases-in-sewer-workers
#3
V Lang, F Lauffer, Y Fincan, T Biedermann, A Zink
BACKGROUND: Skin diseases affect 30-70% of the world population, and globally, skin cancer rates are continuously increasing. In this respect, prevention programs and early detection of skin diseases are of particular importance. OBJECTIVES: To screen sewer workers for skin diseases with regard to their work-related risk. METHODS: Employees of the municipal utilities in Munich (Münchner Stadtentwässerung) underwent a whole-body examination of the skin, conducted by two dermatologists...
April 25, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29683291/daylight-pdt-for-field-cancerization-lessons-from-molecular-biology
#4
Max Rybarski, Lutz Schmitz, Ben Novak, Thomas Dirschka
Actinic keratoses (AKs) represent in-situ squamous cell carcinomas that potentially invade subepidermal structures and may metastasize. Until now, it is unpredictable to determine which AK lesions show this aggressive behaviour. As AKs usually occur in large sun exposed areas, field-directed treatments have become the standard treatment regimen. Among these, conventional photodynamic therapy (cPDT) with 5- aminolaevulinic acid (ALA) or methyl-aminolevulinate (MAL) using red light is particularly effective in the treatment of AKs, but acceptance of the therapy is impaired by severe pain during treatment...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29593028/5-fluorouracil-enhances-protoporphyrin-ix-accumulation-and-lesion-clearance-during-photodynamic-therapy-of-actinic-keratoses-a-mechanism-based-clinical-trial
#5
Edward V Maytin, Sanjay Anand, Margo Riha, Sara Lohser, Alejandra Tellez, Rim Ishak, Lauren Karpinski, Janine Sot, Bo Hu, Anton Denisyuk, Scott C Davis, Angela Kyei, Allison Vidimos
PURPOSE: Actinic keratoses (AK) are precancerous lesions that can progress to squamous cell carcinoma. Photodynamic therapy (PDT) and topical 5-fluorouracil (5FU) are commonly used for AK. Empirical reports suggest that combining them can improve the therapeutic response. However, the optimal combined regimen was not clear in terms of proper sequence, timing, and mechanism. This clinical study explored mechanisms of action for neoadjuvantal 5FU and PDT for treatment of AK. EXPERIMENTAL DESIGN: A bilaterally controlled trial (17 patients) was performed...
March 28, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29587662/randomized-clinical-trial-testing-the-efficacy-and-safety-of-0-5-colchicine-cream-versus-photodynamic-therapy-with-methyl-aminolevulinate-in-the-treatment-of-skin-field-cancerization-study-protocol
#6
Anna Carolina Miola, Eliane Roio Ferreira, Luciana Patricia Fernandes Abbade, Juliano Vilaverde Schmitt, Helio Amante Miot
BACKGROUND: The primary clinical manifestation of skin field cancerization is the presence of actinic keratoses (AKs). Current treatments for AKs related to skin field cancerization include photodynamic therapy (PDT) and colchicine. The objective of this study is to evaluate the efficacy and safety of 0.5% colchicine cream versus PDT with methyl aminolevulinate (MAL-PDT) in the treatment of skin field cancerization. METHODS: In a randomized controlled and open clinical trial with a blind histopathological and immunohistochemical analysis, 36 patients with up to 10 AKs on their forearms will be included from the outpatient clinic...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29582369/field-cancerization-therapies-for-management-of-actinic-keratosis-a-narrative-review
#7
REVIEW
Nathan Jetter, Neha Chandan, Stephanie Wang, Maria Tsoukas
Actinic keratoses (AKs) are atypical, precancerous proliferations of keratinocytes that develop because of chronic exposure to ultraviolet (UV) radiation. Treatment of AK can be lesion-directed or field-directed. Field cancerization theory postulates that the skin surrounding AK is also at increased risk for possible malignant transformation since it has been exposed to the same chronic UV light. Field-directed therapies thus have the potential to address subclinical damage, reduce AK recurrence rates, and potentially reduce the risk of squamous cell carcinoma (SCC) development...
March 26, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29578627/various-cold-plasma-devices-for-the-treatment-of-actinic-keratosis
#8
P C Friedman, V Miller, G Fridman, A Fridman
We have read with interest the letter entitled "Actinic keratoses treated with cold atmospheric plasma" by Wirtz et al.1 and we are glad to see that other dermatologists are corroborating our February, 20172 report on the use of cold plasma to treat actinic keratoses. We hope this will encourage the use of plasma for other clinical indications. Undoubtedly, a number of new studies of cold plasma treatment of actinic keratoses will appear given the great advantages of this treatment modality. This article is protected by copyright...
March 26, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29570823/a-pediatric-case-of-squamous-cell-cancer-in-situ-in-the-setting-of-sclerodermatous-graft-versus-host-disease-and-voriconazole-treatment
#9
Alvin W Li, Leah E Lalor, Fernanda Bellodi Schmidt, Minnelly Luu
Sclerodermatous graft-versus-host disease is a subtype of cutaneous chronic graft-versus-host disease that is characterized by sclerosis of the skin and subcutaneous tissue, resulting in debilitating contractures, among other life-threatening complications. Children with sclerodermatous graft-versus-host disease are at high risk of developing nonmelanoma skin cancer because of several risk factors, including young age at transplantation, prolonged immunosuppression, and exposure to photosensitizing antimicrobial prophylaxis such as voriconazole...
March 23, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29537445/intralesional-and-laser-assisted-5-fluorouracil-in-dermatologic-disease-a-systematic-review
#10
Garrett T Prince, Michael C Cameron, Ramin Fathi, Theodore Alkousakis
INTRODUCTION: 5-fluorouracil has proven to be an effective therapy in the treatment of a variety of dermatologic conditions. Approved by the United States Food and Drug Administration for the topical treatment of actinic keratoses and superficial basal cell carcinoma, 5-fluorouracil has also demonstrated efficacy in the treatment of a variety of other dermatologic diseases. While best known for its use as a topical medication, 5-fluorouracil can also be delivered intralesionally for the treatment of dermatologic disease...
March 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29485253/daylight-photodynamic-therapy-with-methyl-aminolevulinate-for-the-treatment-of-actinic-keratoses-of-the-forearms
#11
Dario Fai, Carlotta Fai, Nicoletta Cassano, Gino A Vena
No abstract text is available yet for this article.
February 26, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29469794/inflamed-actinic-keratoses-associated-with-pemetrexed-and-carboplatin-therapy
#12
Jimmy Lam, Samantha R Ellis, Raja K Sivamani
Eruptive actinic keratosis (AK) consequent to systemic chemotherapy can be confused with drug allergies. We present the first case of inflamed AKs in one patient after receiving combination therapy with pemetrexed and carboplatin.A 68-year-old woman with non-small cell lung adenocarcinoma (NSCLC) presented with numerous pruritic ill-defined, gritty, erythematous papules consistent with AKs on her upper chest, upper back, and arms two weeks after completing the first cycle of combination therapy with carboplatin and pemetrexed...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469732/mycobacterium-fortuitum-infection-after-acupuncture-treatment
#13
T Gracia-Cazaña, A Milagro, F Queipo, Y Gilaberte
Actinic keratoses are cutaneous lesions that appear as the result of the proliferation of atypical keratinocytes. These lesions are considered pre-malignant and they can progress to squamous cell carcinoma. Ingenol mebutate has been approved as an effective treatment for AK on the face and trunk. We studied the local skin reactions to this therapy. Data about local skin reactions were collected in a series of 5 patients with photographic documentation, a visual analog scale, and a ranking of satisfaction of the patient...
September 19, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469731/local-skin-reactions-following-the-administration-of-topical-ingenol-mebutate-for-actinic-keratosis
#14
Alberto Conde-Taboada, Bárbara Mercado, Beatriz Aranegui, Elena González-Guerra, Eduardo López-Bran
Actinic keratoses are cutaneous lesions that appear as the result of the proliferation of atypical keratinocytes. These lesions are considered pre-malignant and they can progress to squamous cell carcinoma. Ingenol mebutate has been approved as an effective treatment for AK on the face and trunk. We studied the local skin reactions to this therapy. Data about local skin reactions were collected in a series of 5 patients with photographic documentation, a visual analog scale, and a ranking of satisfaction of the patient...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447639/a-patient-case-highlighting-the-myriad-of-cutaneous-adverse-effects-of-prolonged-use-of-hydroxyurea
#15
Brett Neill, Ted Ryser, John Neill, Daniel Aires, Anand Rajpara
BACKGROUND: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer. CASE PRESENTATION: We report a 67-year-oldman with a history of polycythemia vera who was referred for management of progressively worsening dorsal hand lesions. The patient presented withhyperpigmentation, ichthyosis, plantar keratoderma, dermatomyositis-like eruptions, two squamous cell carcinomas, and actinic keratoses...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29417799/a-synthesis-of-the-world-s-guidelines-on-photodynamic-therapy-for-non-melanoma-skin-cancer
#16
Colin A Morton
Photodynamic therapy (PDT), using topically administered photosensitizing agents, is widely approved as a treatment for certain nonmelanoma skin cancers. As a tissue-sparing non-surgical modality, there is great potential for PDT to enhance the choice of therapies available to treat, and potentially prevent, skin cancer. Treatment-specific guidelines have assessed the evidence for various photosensitizing agents and light sources, dosimetry, and evaluate reported adverse effects. Discomfort is frequently experienced during treatment but no analgesia was required in most pivotal lesion-directed studies...
February 7, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29410720/auricular-acupuncture-and-skin-cancer-detection-an-opportunity
#17
Daniel G Federman, Jurgen L Holleck
Background: Auricular acupuncture is effective for many patients with pain. Many skin malignancies and precancerous lesions are found on the head and neck. Practitioners of acupuncture are in a unique situation to detect cutaneous malignancy at an early state. Case: An 83-year-old man referred for Battlefield Acupuncture was found to have a scalp lesion suspicious for malignancy as well as several precancerous lesions. Results: Referral to a dermatologist led to excision of a basal-cell cancer and treatment of actinic keratoses...
February 1, 2018: Medical Acupuncture
https://www.readbyqxmd.com/read/29399258/three-day-field-treatment-with-ingenol-disoxate-leo-43204-for-actinic-keratosis-cosmetic-outcomes-and-patient-satisfaction-from-a-phase-ii-trial
#18
Brian Berman, Stephen Tyring, Walter K Nahm, Marie Louise Østerdal, Astrid H Petersen, Daniel M Siegel
Objective: To report cosmetic outcomes and patient satisfaction with ingenol disoxate (LEO 43204) used in a once-daily, three-day field treatment regimen in patients with actinic keratosis. Design: This was a phase II, multicenter, open-label trial (ClinicalTrials.gov: NCT02305888) involving 20 trial sites in the United States. Participants: Patients with between five and 20 clinically typical actinic keratoses lesions on the full face/250cm2 on the chest, 25cm2 to 250cm2 on the scalp, or 250cm2 on the trunk/extremities were included...
November 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29344318/noninvasive-long-term-monitoring-of-actinic-keratosis-and-field-cancerization-following-treatment-with-ingenol-mebutate-gel-0-015
#19
Orit Markowitz, Katie Wang, Amanda Levine, Michelle Schwartz, Sumeet Minhas, Eleanor Feldman, Daniel M Siegel
OBJECTIVE: To determine whether actinic keratosis and photodamaged perilesional areas (field cancerization) treated successfully with topical ingenol mebutate gel 0.015% remained clear one year later, and to treat actinic keratosis and perilesional skin not treated one year earlier. DESIGN: Single-center, single-arm, open-label extension of an original clinical study completed one year earlier. SETTING: An outpatient clinic. PARTICIPANTS: Fifteen of the original 28 study patients enrolled in and who completed the extension phase...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29330682/life-threatening-reaction-with-topical-5-fluorouracil
#20
Patrick Kishi, Cynthia J Price
A 67-year-old man developed a suspected adverse drug reaction during treatment with topical 5-fluorouracil (5-FU) for multiple actinic keratosis of the face, neck, and forearms. The man received topical 5-FU at a dosage of 0.5% for the actinic keratoses. After 1 week, he developed extreme lethargy, fatigue, fever, and mouth erosions. Several days later, and after discontinuation of 5-FU, painful mucositis and systemic side effects occurred, meeting criteria for hospitalization because of dehydration and a 6...
January 12, 2018: Drug Safety—Case Reports
keyword
keyword
77137
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"