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A Diouf, A Cisse, S S Gueye, V Mendes, T Siby, R M Diouf Diop, E Bassene
The study was based on an aqueous extract derived from a 60 degrees ethanolic tincture containing 0.032 g of dry matter per ml. The leaves of Guiera senegalensis Lam (Combretaceae) were collected in December 1991 at Nguekhokh a village within 20 km from Mbour (Senegal). The extract was administered for six months through daily forced-feeling at 2 g/kg to Wistar male and female rats whose weight at the beginning of the experiment tanged between 140 g and 180 g. The urine was analysed during the study and the animals were weighed every four weeks...
2000: Dakar Médical
Steven Rossi, Tony Yaksh
A facile and sensitive method utilizing solid-phase cartridge extraction and capillary gas chromatography (GC) with nitrogen phosphorus detection was validated for the determination of MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclo-hepten-5,10-imine maleate], a non-competitive NMDA receptor antagonist, in dog cerebrospinal fluid (CSF) and plasma. Clonidine hydrochloride was used as the internal standard (ISTD), after evaluation of several ISTD candidates. Separations were performed with an intermediate polarity fused silica capillary column, yielding typical retention times of 3...
February 26, 2003: Journal of Pharmaceutical and Biomedical Analysis
A G Davison, M G Britton, J A Forrester, R J Davies, D T Hughes
Three merchant seamen and two laboratory workers who developed allergic symptoms following exposure to castor beans have been investigated. Bronchial-provocation testing with castor beans in the merchant seamen demonstrated a late reaction in two. Specific IgE against whole castor-bean extract and ricin, ricinus agglutinin and dericinated extracts of castor bean were found in the patients' sera using radioallergosorbent tests (RAST). RAST inhibition, toxocological and haemagglutination tests suggest that the ricin and dericinated extracts contain distinct allergens...
November 1983: Clinical Allergy
I West
Over the past 25 years there has been a remarkable proliferation of new chemicals into our environment, among them the 57,000 different trade-named pesticide formulations now for sale in the United States. With them have come many new problems to physicians needing up-to-the minute toxocologic information, and also sizable problems in public health. Technology must be harnessed to bring to physicians, when they need it, help in the diagnosis and treatment of poisoning and other adverse effects from modern chemicals, for at present it is impossible for the practicing physician to keep up with what is known and unknown about the toxicology of all of these chemicals...
October 1966: California Medicine
R H Drost, J F Reith
No abstract text is available yet for this article.
December 22, 1967: Pharmaceutisch Weekblad
L M Vlasenko
No abstract text is available yet for this article.
March 1970: Farmatsiia
A R Hagen
No abstract text is available yet for this article.
October 1967: Den Norske Tannlaegeforenings Tidende
H G Eigendorf
No abstract text is available yet for this article.
April 1988: Die Pharmazie
M T Akay, A Elcüman, M Nurcan, D Kolankaya, G Yilmazoglu
Lentil grains treated with malathion and stored under laboratory conditions for 12 months formed bound residues. Bioavailability and the effects of lentil-bound residues of malathion in rats were studied. The amount of bound residues in lentils treated with 14C-malathion at 10 ppm and 50 ppm gradually increased to 9.52% and 13.01% of the initially applied doses after 12 months. When rats were fed these 14C-bound residues, radioactivity excreted in urine accounted for 34.49% of the administered dose. In feces, 26...
August 1992: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
J Fossion, J P Osselaere
No abstract text is available yet for this article.
January 1976: Journal de Pharmacie de Belgique
A M Il'in
Investigations of prothionamide effected on different animal species showed the drug to be of low toxicity. In relatively big doses it produced adynamia, hypothermy and a fall of arterial pressure. When employed in doses much higher (by 10-20 times) than therapeutic ones for humans prothionamide, when used repeatedly, may exercise a hepatotoxic action.
July 1975: Farmakologiia i Toksikologiia
J Dequidt, F Erb, J Pommery
The authors, after having performed the preparation of a few pure trichlorobiphenyl isomers, proceeded with a preliminary toxicological study of the rat which should then facilitate study for a commerical product. The fixation level of these compounds is considerably higher in lipids and in the spleen than in the other organs. Urinary elimination is very low compared with faecal excretion; furthermore, chromatographic analysis makes it possible to shed light on phenolic products of transformation in the excreta, some of which it was possible to identify with hydroxylated trichlorobiphenyls synthesized in the laboratory...
January 1976: European Journal of Toxicology and Environmental Hygiene. Journal Européen de Toxicologie
H Cwajda, M Woyke
Rabbits were exposed to carbon disulphide vapour in toxocological chamber. Increased platelet adhesiveness was found in exposed animals, dependent on CS2 concentration in the chamber and duration of intoxication. The authors suggest that the increased platelet adhesiveness may result from lipid metabolism disturbances.
1978: Medycyna Pracy
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