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JOURNAL ARTICLE
John R Speakman, Thorkild I A Sørensen, Kevin D Hall, David B Allison
Obesity is now a global pandemic, but there is little consensus about the causes.
September 2023: Science
#22
JOURNAL ARTICLE
Stanley C Wei, Dane Freeman, Austin Himschoot, Kristie E N Clarke, Miriam E Van Dyke, Jennifer Adjemian, Farida B Ahmad, Tina J Benoit, Kevin Berney, Adi V Gundlapalli, Aron J Hall, Fiona Havers, S Jane Henley, Charity Hilton, Dylan Johns, Jean D Opsomer, Huong T Pham, Matthew J Stuckey, Christopher A Taylor, Jefferson M Jones
BACKGROUND: Because COVID-19 case data do not capture most SARS-CoV-2 infections, the actual risk of severe disease and death per infection is unknown. Integrating sociodemographic data into analysis can show consequential health disparities. METHODS: Data from September 2020--November 2021 from six national surveillance systems in matched geographical areas were merged and analyzed to estimate numbers of COVID-19-associated cases, emergency department visits, and deaths per 100,000 infections...
August 24, 2023: Journal of Infectious Diseases
#23
JOURNAL ARTICLE
Sriram Venneti, Abed Rahman Kawakibi, Sunjong Ji, Sebastian M Waszak, Stefan R Sweha, Mateus Mota, Matthew Pun, Akash Deogharkar, Chan Chung, Rohinton S Tarapore, Samuel Ramage, Andrew Chi, Patrick Y Wen, Isabel Arrillaga-Romany, Tracy T Batchelor, Nicholas A Butowski, Ashley Sumrall, Nicole Shonka, Rebecca A Harrison, John de Groot, Minesh Mehta, Matthew D Hall, Doured Daghistani, Timothy F Cloughesy, Benjamin M Ellingson, Kevin Beccaria, Pascale Varlet, Michelle M Kim, Yoshie Umemura, Hugh Garton, Andrea Franson, Jonathan Schwartz, Rajan Jain, Maureen Kachman, Heidi Baum, Charles F Burant, Sophie L Mottl, Rodrigo T Cartaxo, Vishal John, Dana Messinger, Tingting Qin, Erik Peterson, Peter Sajjakulnukit, Karthik Ravi, Alyssa Waugh, Dustin Walling, Yujie Ding, Ziyun Xia, Anna Schwendeman, Debra Hawes, Fusheng Yang, Alexander R Judkins, Daniel Wahl, Costas A Lyssiotis, Daniel de la Nava, Marta M Alonso, Augustine Eze, Jasper Spitzer, Susanne V Schmidt, Ryan J Duchatel, Matthew D Dun, Jason E Cain, Li Jiang, Sylwia A Stopka, Gerard Baquer, Michael S Regan, Mariella G Filbin, Nathalie Y R Agar, Lili Zhao, Chandan Kumar-Sinha, Rajen Mody, Arul Chinnaiyan, Ryo Kurokawa, Drew Pratt, Viveka N Yadav, Jacques Grill, Cassie Kline, Sabine Mueller, Adam Resnick, Javad Nazarian, Joshua E Allen, Yazmin Odia, Sharon L Gardner, Carl Koschmann
H3K27M-mutant diffuse midline glioma (DMG) patients have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/CSF correlate samples from patients treated in two completed multi-site clinical studies. Patients treated with ONC201 following initial radiation but prior to recurrence demonstrated a median overall survival of 21.7 months, while those treated after recurrence had a median overall survival of 9...
August 16, 2023: Cancer Discovery
#24
JOURNAL ARTICLE
Manjot Birk, Kara Sidhu, Marina Rosa Filezio, Vishwajeet Singh, Fabio Ferri-de-Barros, Vivien Chan, Geoffrey Shumilak, Andrew Nataraj, Holly Langston, Nicholas J Yee, Carlo Iorio, Nicholas Shkumat, Brett Rocos, Birgit Ertl-Wagner, David Lebel, Mark W Camp, Evan Dimentberg, Neil Saran, Melissa Laflamme, Jean A Ouellet, Jessica Wenghofer, Holly Livock, Luke Beaton, Andrew Tice, Kevin Smit, Ryan Graham, Matias Pereira Duarte, Marjolaine Roy-Beaudry, Isabelle Turgeon, Julie Joncas, Jean-Marc Mac-Thiong, Hubert Labelle, Soraya Barchi, Stefan Parent, Tara Gholamian, Holly Livock, Andrew Tice, Kevin Smit, Samuel Yoon, Amna Zulfiqar, Brett Rocos, Anne Murphy, Natasha Bath, Stanley Moll, Julia Sorbara, David Lebel, Mark W Camp, Jérémie Arthur Nallet, Brett Rocos, David Eduard Lebel, Reinhard Zeller, Jennifer A Dermott, Dorothy J Kim, Alison Anthony, Reinhard Zeller, David E Lebel, Zhi Wang, Jesse Shen, Youssef Kamel, Jia Liu, Daniel Shedid, Fidaa Al-Shakfa, Sung-Joo Yuh, Ghassan Boubez, Maroun Rizkallah, Maroun Rizkallah, Jesse Shen, Ghassan Boubez, Youssef Kamel, Jia Liu, Daniel Shedid, Fidaa Al-Shakfa, Frederic Lavoie, Sung-Joo Yug, Zhi Wang, Fatemeh Alavi, Christopher Nielsen, Raja Rampersaud, Stephen Lewis, Angela M Cheung, Chloe Cadieux, Renan Fernandes, Pawel Brzozowski, Radovan Zdero, Chris Bailey, Parham Rasoulinejad, Ahmed Cherry, Ragavan Manoharan, Mark Xu, Nisaharan Srikandarajah, Carlo Iorio, Aditya Raj, Christopher Nielsen, Raja Rampersaud, Stephen Lewis, Kristen Beange, Ryan Graham, Holly Livock, Kevin Smit, Ragavan Manoharan, Ahmed Cherry, Nisaharan Srikandarajah, Aditya Raj, Mark Xu, Carlo Iorio, Christopher J Nielsen, Y Raja Rampersaud, Stephen J Lewis, Ali Asghar Mohammadi Nasrabadi, Gemah Moammer, John Mc Phee, Taryn Walker, Jennifer C Urquhart, R Andrew Glennie, Y Raja Rampersaud, Charles G Fisher, Chris S Bailey, Brandon J Herrington, Renan R Fernandes, Jennifer C Urquhart, Parham Rasoulinejad, Fawaz Siddiqi, Christopher S Bailey, Jennifer Urquhart, Renan R Fernandes, R Andrew Glennie, Y Raja Rampersaud, Charles G Fisher, Chris S Bailey, Michael M H Yang, Jay Riva-Cambrin, Jonathan Cunningham, Steven Casha, Chloe N Cadieux, Jennifer Urquhart, Renan Fernandes, Andrew Glennie, Charles Fisher, Raja Rampersaud, Mark Xu, Ragavan Manoharan, Ahmed Cherry, Aditya Raj, Nish Srikandarajah, Carlo Iorio, Christopher Nielsen, Stephen Lewis, Raja Rampersaud, Ahmed Cherry, Aditya Raj, Greg McIntosh, Ragavan Manoharan, Jean-Christophe Murray, Christopher Nielsen, Mark Xu, Nisaharan Srikandarajah, Carlo Iorio, Anthony Perruccio, Mayilee Canizares, Raja Rampersaud, Dana El-Mughayyar, Erin Bigney, Eden Richardson, Neil Manson, Edward Abraham, Najmedden Attabib, Chris Small, George Kolyvas, Andre LeRoux, Canadian Spine Outcomes, Research Network Investigators, Jeff Hebert, Victor Baisamy, Maroun Rizkallah, Jesse Shen, Thierry Cresson, Carlos Vazquez, Zhi Wang, Ghassan Boubez, Tiffany Lung, Mayilee Canizares, Anthony Perruccio, Raja Rampersaud, Eric J Crawford, Robert A Ravinsky, Anthony V Perruccio, Y Raja Rampersaud, Peter C Coyte, Michael Bond, John Street, Charles Fisher, Raphaele Charest-Morin, Jason M Sutherland, Arthur R Bartolozzi, Ori Barzilai, Dean Chou, Ilya Laufer, Jorrit-Jan Verlaan, Arjun Sahgal, Laurence D Rhines, Daniel M Scuibba, Aron Lazary, Michael H Weber, James M Schuster, Stefano Boriani, Chetan Bettegowda, Paul M Arnold, Michelle J Clarke, Michael G Fehlings, Jeremy J Reynolds, Ziya L Gokaslan, Charles G Fisher, Nicolas Dea, Anne L Versteeg, Raphaele Charest-Morin, Ilya Laufer, William Teixeira, Ori Barzilai, Alessandro Gasbarrini, Michael G Fehlings, Dean Chou, Michael G Johnson, Ziya L Gokaslan, Nicolas Dea, Jorrit-Jan Verlaan, Tony Goldschlager, John H Shin, John E O'Toole, Daniel M Sciubba, Chetan Bettegowda, Michelle J Clarke, Michael H Weber, Addisu Mesfin, Norio Kawahara, Rory Goodwin, Alexander Disch, Aron Lazary, Stefano Boriani, Arjun Sahgal, Laurence Rhines, Charles G Fisher, Anne L Versteeg, Roxanne Gal, Leilani Reich, Angela Tsang, Allan Aludino, Arjun Sahgal, Jorrit-Jan Verlaan, Charles G Fisher, Lenny Verkooijen, Maroun Rizkallah, Zhi Wang, Sung-Joo Yuh, Daniel Shedid, Jesse Shen, Fidaa Al-Shakfa, Céline Belguendouz, Rayan AlKafi, Ghassan Boubez, Mark A MacLean, Miltiadis Georgiopoulos, Raphaele Charest-Morin, Niccole Germscheid, C Rory Goodwin, Michael Weber, Ao Spine International, Maroun Rizkallah, Ghassan Boubez, Hao Zhang, Fidaa Al-Shakfa, Pamela Brindamour, Danielle Boule, Jesse Shen, Daniel Shedid, Sung-Joo Yuh, Zhi Wang, Marcia Rebecca Correale, Leslie Jayne Soever, Raja Rampersaud, Claudia Cristina Malic, Melanie Dubreuil, Kate Duke, Stephen P Kingwell, Zihan Lin, Mark A MacLean, Lisa C Julien, Glenn Patriquin, Jason LeBlanc, Ryan Green, Jacob Alant, Sean Barry, R Andrew Glennie, William Oxney, Sean D Christie, Mohamed Sarraj, Abdullah Alqahtani, Patrick Thornley, Frank Koziarz, Christopher S Bailey, Millaray Freire-Archer, Kunal Bhanot, Edward Kachur, Mohit Bhandari, Colby Oitment, Armaan K Malhotra, Michael Balas, Blessing N R Jaja, Erin M Harrington, Johann Hofereiter, Rachael H Jaffe, Yingshi He, James P Byrne, Jefferson R Wilson, Christopher D Witiw, Kennedy C M Brittain, Sean Christie, Saranyan Pillai, Marcel F Dvorak, Nathan Evaniew, Melody Chen, Zeina Waheed, Naama Rotem-Kohavi, Nader Fallah, Vanessa K Noonan, Charles G Fisher, Raphaële Charest-Morin, Nicolas Dea, Tamir Ailon, John Street, Brian K Kwon, Ryan V Sandarage, Ahmad Galuta, Diana Ghinda, Jason C S Kwan, Eve C TsaI, Laureen D Hachem, James Hong, Alexander Velumian, Andrea J Mothe, Charles H Tator, Michael G Fehlings, Husain Shakil, Blessing N R Jaja, Peng Zhang, Rachael Jaffe, Armaan K Malhotra, Jefferson R Wilson, Christopher D Witiw, Naama Rotem-Kohavi, Marcel F Dvorak, Nicolas Dea, Nathan Evaniew, Melody Chen, Zeina Waheed, Jijie Xu, Nader Fallah, Vanessa Noonan, Brian Kwon, Charlotte Dandurand, Sander Muijs, Marcel Dvorak, Klaus Schnake, Cumhur, Ouml Ner, Ryan Greene, Bradley Furlong, Jenna Smith-Forrester, Michelle Swab, Sean D Christie, Amanda Hall, Erika Leck, Emily Marshall, Sean Christie, Marcel F Dvorak, F Cumhur, Ouml Ner, Alexander R Vaccaro, Lorin M Benneker, Shanmuganathan Rajasekaran, Mohammad El-Sharkawi, Eugen Cezar Popescu, Jin Wee Tee, Jerome Paquet, John C France, Richard Allen, William F Lavelle, Miguel Hirschfeld, Spyros Pneumaticos, Charlotte Dandurand, Cumhur, Ouml Ner, Sander Muijs, Klaus Schnake, Marcel Dvorak, Renan Rodrigues Fernandes, Patrick Thornley, Jennifer Urquhart, Sean Kelly, Nasser Alenezi, Abdulmajeed Alahmari, Fawaz Siddiqi, Supriya Singh, Parham Rasoulinejad, Christopher Bailey, Nathan Evaniew, Lukas D Burger, Nicolas Dea, David W Cadotte, Greg McIntosh, Bradley Jacobs, Loïc St-Laurent-Lebeux, Étienne Bourassa-Moreau, Mohamed Sarraj, Meerab Majeed, Daipayan Guha, Markian Pahuta, Mathieu Laflamme, Greg McIntosh, Nicolas Dea, Alex B Bak, Mohammed A Alvi, Ali Moghaddamjou, Michael G Fehlings, Yan Gabriel Morais David Silva, Julien Goulet, Greg McIntosh, Sonia Bedard, Newton Pimenta, Jocelyn Blanchard, Jerome Couture, Bernard LaRue, Csorn Investigators, Tyler Adams, Erin Cunningham, Dana El-Mughayyar, Erin Bigney, Amanda Vandewint, Niel Manson, Edward Abraham, Chris Small, Najmedden Attabib, Eden Richardson, Jeffery Hebert, Michael Bond, John Street, Charles Fisher, Raphaele Charest-Morin, Jason M Sutherland, Troy Hillier, Chris S Bailey, Charles Fisher, Raja Rampersaud, Prosper Koto, R Andrew Glennie, Alex Soroceanu, Fred Nicholls, Ken Thomas, Nathan Evaniew, Peter Lewkonia, Jacques Bouchard, Brad Jacobs, David Ben-Israel, Eric J Crawford, Charles Fisher, Nicolas Dea, Eldon Spackman, Raja Rampersaud, Kenneth C Thomas, Nisaharan Srikandarajah, Jean-Christophe Murray, Christopher Nielsen, Ragavan Manoharan, Ahmed Cherry, Aditiya Raj, Mark Xu, Carlo Iorio, Chris Bailey, Nicolas Dea, Charles Fisher, Hamilton Hall, Neil Manson, Kenneth Thomas, Mayilee Canizares, Yoga Raja Rampersaud, Jennifer Urquhart, Renan R Fernandes, R Andrew Glennie, Y Raja Rampersaud, Charles G Fisher, Chris Bailey, Michael M H Yang, Rena Far, Tolulope Sajobi, Jay Riva-Cambrin, Steven Casha, Michael Bond, John Street, Charles Fisher, Raphaele Charest-Morin, Jason M Sutherland, Yan Silva, Newton Godoy Pimenta, Bernard LaRue, Sonia Bedard, Sonia Cheng Oviedo, Julien Goulet, Jerome Couture, Jocelyn Blanchard, James McDonald, Fares Al-Jahdali, Jennifer Urquhart, Abdulmajeed Alahmari, Raja Rampersaud, Charles Fisher, Chris Bailey, Andrew Glennie, Nathan Evaniew, Matthew Coyle, Y Raja Rampersaud, Christopher S Bailey, W Bradley Jacobs, David W Cadotte, Kenneth C Thomas, Najmedden Attabib, Jérôme Paquet, Andrew Nataraj, Sean D Christie, Michael H Weber, Philippe Phan, Raphaële Charest-Morin, Charles G Fisher, Hamilton Hall, Greg McIntosh, Nicolas Dea, Armaan K Malhotra, Aileen M Davis, Yingshi He, Erin M Harrington, Blessing N R Jaja, Mary P Zhu, Husain Shakil, Nicolas Dea, W Bradley Jacobs, David W Cadotte, Jérôme Paquet, Michael H Weber, Philippe Phan, Sean D Christie, Andrew Nataraj, Christopher S Bailey, Michael G Johnson, Charles G Fisher, Neil Manson, Y Raja Rampersaud, Kenneth C Thomas, Hamilton Hall, Michael G Fehlings, Henry Ahn, Howard J Ginsberg, Christopher D Witiw, Jefferson R Wilson, Alwalaa Althagafi, Greg McIntosh, Raphaële Charest-Morin, Michael A Rizzuto, Tamir Ailon, Nicolas Dea, Nathan Evaniew, Bradley W Jacobs, Jerome Paquet, Raja Rampersaud, Hamilton Hall, Christopher S Bailey, Michael Weber, Michael G Johnson, Andrew Nataraj, Najmedden Attabib, David W Cadotte, Neil Manson, Alexandra Stratton, Sean D Christie, Kenneth C Thomas, Jefferson R Wilson, Charles G Fisher, Raphaele Charest-Morin, Alex B Bak, Mohammed A Alvi, Ali Moghaddamjou, Michael G Fehlings, Alex B Bak, Mohammed A Alvi, Ali Moghaddamjou, Michael G Fehlings, Alex Soroceanu, Fred Nicholls, Ken Thomas, Nathan Evaniew, Paul Salo, Jacques Bouchard, Brad Jacobs, Charlotte Dandurand, Pedram Farimani Laghaei, Tamir Ailon, Raphaele Charest-Morin, Nicolas Dea, Marcel Dvorak, Charles Fisher, Brian K Kwon, Scott Paquette, John Street, Alex Soroceanu, Fred Nicholls, Ken Thomas, Nathan Evaniew, Jacques Bouchard, Paul Salo, Brad Jacobs, Vishal P Varshney, Ramesh Sahjpaul, Scott Paquette, Jill Osborn, Alex B Bak, Ali Moghaddamjou, Michael G Fehlings, Erika Leck, Emily Marshall, Sean Christie, Lior M Elkaim, Oliver J Lasry, Aditya Raj, Jean-Christophe Murray, Ahmed Cherry, Greg McIntosh, Christopher Nielsen, Nisaharan Srikandarajah, Ragavan Manoharan, Carlo Iorio, Mark Xu, Anthony Perruccio, Mayilee Canizares, Yoga Raja Rampersaud, Alexandra Stratton, Sarah Tierney, Eugene K Wai, Philippe Phan, Stephen Kingwell, Marie-Claude Magnan, Alex Soroceanu, Fred Nicholls, Ken Thomas, Nathan Evaniew, Paul Salo, Jacques Bouchard, Brad Jacobs, Barend Spanninga, Thomáy-Claire A Hoelen, Scott Johnson, Jacobus J C Arts, Chris S Bailey, Jennifer C Urquhart, R Andrew Glennie, Y Raja Rampersaud, Charles G Fisher, Jordan J Levett, Lior M Elkaim, Naif M Alotaibi, Michael H Weber, Nicolas Dea, Muhammad M Abd-El-Barr, Ahmed Cherry, Albert Yee, Nadia Jaber, Michael Fehlings, Erin Cunningham, Tyler Adams, Dana El-Mughayyar, Erin Bigney, Amanda Vandewint, Neil Manson, Edward Abraham, Chris Small, Najmedden Attabib, Eden Richardson, Jeffery Hebert, Joel Werier, Kevin Smit, James Villeneuve, Adam Sachs, Hesham Abdelbary, Yusra Kassim Al-Mosuli, Kawan Rakhra, Philippe Phan, Kosei Nagata, Jeffrey L Gum, Morgan E Brown, Christy L Daniels, Leah Y Carreon, John-Peter Bonello, Robert Koucheki, Aazad Abbas, Johnathan Lex, Nicholas Nucci, Cari Whyne, Jeremie Larouche, Henry Ahn, Joel Finkelstein, Stephen Lewis, Jay Toor, Nathan J Lee, Lindsay D Orosz, Jeffrey L Gum, Gregory T Poulter, Ehsan Jazini, Colin M Haines, Christopher R Good, Ronald A Lehman, Eric J Crawford, Robert A Ravinsky, Anthony V Perruccio, Peter C Coyte, Y Raja Rampersaud, Millaray Freire-Archer, Mohamed Sarraj, Fawaz AlShaalan, Alex Koziarz, Patrick Thornley, Haitham Alnemari, Colby Oitment, Lalita Bharadwaj, Dana El-Mughayyar, Erin Bigney, Neil Manson, Edward Abraham, Chris Small, Najmedden Attabib, Eden Richardson, Jill Kearney, Uday Kundap, Csorn Investigators, Jeffrey Hebert, Lior M Elkaim, Jordan J Levett, Farbod Niazi, Rakan Bokhari, Naif M Alotaibi, Oliver J Lasry, Vincent Bissonnette, David Yen, Varun S Muddaluru, Pranjan Gandhi, Alexander Mastrolonardo, Daipayan Guha, Markian A Pahuta, Sean D Christie, Trevor Vandertuin, Gillian Ritcey, Daniel Rainham, Mamdoh Alhawsawi, Rohail Mumtaz, Mark Abdelnour, Feras Qumquji, Alex Soroceanu, Ganesh Swamy, Kenneth Thomas, Eugene Wai, Philippe Phan, Fenil R Bhatt, Lindsay D Orosz, Tarek Yamout, Christopher R Good, Thomas C Schuler, Tiffany Nguyen, Ehsan Jazini, Colin M Haines, Marcelo Oppermann, Shaurya Gupta, Joel Ramjist, Priscila Santos Oppermann, Victor X D Yang, Jordan J Levett, Lior M Elkaim, Farbod Niazi, Michael H Weber, Christian Ioro-Morin, Marco Bonizzato, Alexander G Weil, Marcelo Oppermann, Joel Ramjist, Shaurya Gupta, Priscila S Oppermann, Victor X D Yang, Youngkyung Jung, Varun Muddalaru, Pranjan Gandhi, Daipayan Guha, Robert Koucheki, John-Peter Bonello, Aazad Abbas, Johnathan R Lex, Nicholas Nucci, Cari Whyne, Albert Yee, Henry Ahn, Joel Finkelstein, Jeremie Larouche, Stephen Lewis, Jay Toor, Alaina Dhawan, Jillian Dhawan, Ajay N Sharma, Daniel B Azzam, Ahmed Cherry, Michael G Fehlings, Lindsay D Orosz, Nathan J Lee, Tarek Yamout, Jeffrey L Gum, Ronald A Lehman, Gregory T Poulter, Colin M Haines, Ehsan Jazini, Christopher R Good, Barzany B Ridha, Amit Persad, Daryl Fourney, Elizabeth Byers, Michelle Gallagher, James Sugar, Justin L Brown, Zhi Wang, Jesse Shen, Ghassan Boubez, Fidaa Al-Shakfa, Sung-Joo Yuh, Daniel Shedid, Maroun Rizkallah, Manmohan Singh, Pankaj Kumar Singh, Peyton Lloyd Lawrence, Shevaughn Dell, Ronette Goodluck-Tyndall, Kevin Wade, Mark Morgan, Carl Bruce, Yan Gabriel Morais David Silva, Newton Pimenta, Bernard LaRue, Salman Aldakhil, Jocelyn Blanchard, Jerome Couture, Julien Goulet, Drew A Bednar, Ruheksh Raj, Jennifer Urquhart, Chris Bailey, Sean D Christie, Ryan Greene, Jennyfer Paulla Galdino Chaves, Mohammed Zarrabian, Leif Sigurdson, Ragavan Manoharan, Ahmed Cherry, Carlo Iorio, Nisaharan Srikandarajah, Mark Xu, Aditya Raj, Christopher J Nielsen, Yoga Raja Rampersaud, Stephen J Lewis
No abstract text is available yet for this article.
2023: Canadian Journal of Surgery. Journal Canadien de Chirurgie
#25
REVIEW
Abigail Marie Klever, Kathleen A Alexander, Deepak Almeida, Matthew Z Anderson, Ray L Ball, Gillian Beamer, Paola Boggiatto, Jane E Buikstra, Bruce Chandler, Tiffany A Claeys, Aislinn E Concha, Paul J Converse, Keith M Derbyshire, Karen M Dobos, Kathryn M Dupnik, Janice J Endsley, Mark A Endsley, Kevin Fennelly, Carlos Franco-Paredes, Deanna A Hagge, Luanne Hall-Stoodley, Don Hayes, Katherine Hirschfeld, Courtney A Hofman, Jennifer R Honda, Natalie M Hull, Igor Kramnik, Karen Lacourciere, Ramanuj Lahiri, Elise A Lamont, Michelle H Larsen, Timothy Lemaire, Sandrine Lesellier, Naomi R Lee, Christopher A Lowry, Najmus S Mahfooz, Temet M McMichael, Marlena R Merling, Michele A Miller, Jyothi F Nagajyothi, Elizabeth Nelson, Eric L Nuermberger, Maria T Pena, Claudia Perea, Brendan K Podell, Charlie J Pyle, Fred D Quinn, Murugesan V S Rajaram, Oscar Rosas Mejia, Michelle Rothoff, Saydie A Sago, Liliana C M Salvador, Andrew W Simonson, John S Spencer, Srinand Sreevatsan, Selvakumar Subbian, James Sunstrum, David M Tobin, K K Vidya Vijayan, Caelan T O Wright, Richard T Robinson
The Many Hosts of Mycobacteria (MHM) meeting series brings together basic scientists, clinicians and veterinarians to promote robust discussion and dissemination of recent advances in our knowledge of numerous mycobacterial diseases, including human and bovine tuberculosis (TB), nontuberculous mycobacteria (NTM) infection, Hansen's disease (leprosy), Buruli ulcer and Johne's disease. The 9th MHM conference (MHM9) was held in July 2022 at The Ohio State University (OSU) and centered around the theme of "Confounders of Mycobacterial Disease...
July 23, 2023: Tuberculosis
#26
Aaron Hengist, Juen Guo, Kevin D Hall
BACKGROUND: Continuous glucose monitors (CGMs) are being used to characterize postprandial glycemic responses and thereby provide personalized dietary advice to minimize glycemic excursions. However, the efficacy of such advice depends on reliable CGM responses. OBJECTIVE: To explore within-subject variability of CGM responses to duplicate meals in an inpatient setting. METHODS: CGM data were collected in two controlled feeding studies ( NCT03407053 and NCT03878108 ) in 30 participants without diabetes capturing 948 meal responses in duplicate ∼1 week apart from three dietary patterns...
June 15, 2023: medRxiv
#27
JOURNAL ARTICLE
Kevin C Klatt, Kevin Bass, John R Speakman, Kevin D Hall
Diet plays a substantial role in the etiology, progression, and treatment of chronic disease and is best considered as a multifaceted set of modifiable input variables with pleiotropic effects on a variety of biological pathways spanning multiple organ systems. This brief review discusses key issues related to the design and conduct of diet interventions in rodent models of metabolic disease and their implications for interpreting experiments. We also make specific recommendations to improve rodent diet studies to help better understand the role of diet on metabolic physiology and thereby improve our understanding of metabolic disease...
June 2023: Life Metab
#28
REVIEW
Kevin D Hall
More people now have obesity than suffer from starvation thanks to our modern food system. Agriculture was transformed over the 20th century by a variety of technological advancements that relied heavily on fossil fuels. In the United States, government policies and economic incentives led to surplus production of cheap inputs to processed food industries that produced a wide variety of heavily marketed, convenient, rewarding, timesaving, and relatively inexpensive ultra-processed foods. The energy available in the food supply increased by much more than the population needs, albeit with large inequities in nutrition security...
September 11, 2023: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
#29
JOURNAL ARTICLE
David B Allison, Thorkild I A Sørensen, Kevin D Hall, John R Speakman
No abstract text is available yet for this article.
September 11, 2023: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
#30
Aaron Hengist, Christina M Sciarrillo, Juen Guo, Mary Walter, Kevin D Hall
Gut-derived hormones affect appetite. Ghrelin increases hunger and decreases after food intake, whereas satiation and satiety are induced by peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and perhaps glucose-dependent insulinotropic polypeptide (GIP) which are increased after food intake [1-3]. These gut-derived appetite hormones have been theorized to play a role in the weight-loss that results from bariatric surgery [4, 5] and agonists of GLP-1 and GIP receptors have become successful medical treatments for obesity [6-8]...
May 11, 2023: medRxiv
#31
JOURNAL ARTICLE
Cory L Holland, Monica F Weis, Corbin J England, Armand M Berry, Paige D Hall, L Kevin Lewis
Exposure of eukaryotic cells to ionizing radiation or clastogenic chemicals leads to formation of DNA double-strand breaks (DSBs). These lesions are also generated internally by chemicals and enzymes, in the absence of exogenous agents, though the sources and consequences of such endogenously generated DSBs remain poorly understood. In the current study, we have investigated the impact of reduced recombinational repair of endogenous DSBs on stress responses, cell morphology and other physical properties of S...
June 30, 2023: Experimental Cell Research
#32
RANDOMIZED CONTROLLED TRIAL
Valerie L Darcey, Juen Guo, Amber B Courville, Isabelle Gallagher, Jason A Avery, W Kyle Simmons, John E Ingeholm, Peter Herscovitch, Alex Martin, Kevin D Hall
BACKGROUNDWeight-loss diets often target dietary fat or carbohydrates, macronutrients that are sensed via distinct gut-brain pathways and differentially affect peripheral hormones and metabolism. However, the effects of such diet changes on the human brain are unclear. METHODSWe investigated whether selective isocaloric reductions in dietary fat or carbohydrates altered dopamine D2/3 receptor binding potential (D2BP) and neural activity in brain-reward regions in response to visual food cues in 17 inpatient adults with obesity as compared with a eucaloric baseline diet using a randomized crossover design...
June 22, 2023: JCI Insight
#33
JOURNAL ARTICLE
Nicholas F G Chen, Chrispin Chaguza, Luc Gagne, Matthew Doucette, Sandra Smole, Erika Buzby, Joshua Hall, Stephanie Ash, Rachel Harrington, Seana Cofsky, Selina Clancy, Curtis J Kapsak, Joel Sevinsky, Kevin Libuit, Daniel J Park, Peera Hemarajata, Jacob M Garrigues, Nicole M Green, Sean Sierra-Patev, Kristin Carpenter-Azevedo, Richard C Huard, Claire Pearson, Kutluhan Incekara, Christina Nishimura, Jian Ping Huang, Emily Gagnon, Ethan Reever, Jafar Razeq, Anthony Muyombwe, Vítor Borges, Rita Ferreira, Daniel Sobral, Silvia Duarte, Daniela Santos, Luís Vieira, João Paulo Gomes, Carly Aquino, Isabella M Savino, Karinda Felton, Moneeb Bajwa, Nyjil Hayward, Holly Miller, Allison Naumann, Ria Allman, Neel Greer, Amary Fall, Heba H Mostafa, Martin P McHugh, Daniel M Maloney, Rebecca Dewar, Juliet Kenicer, Abby Parker, Katharine Mathers, Jonathan Wild, Seb Cotton, Kate E Templeton, George Churchwell, Philip A Lee, Maria Pedrosa, Brenna McGruder, Sarah Schmedes, Matthew R Plumb, Xiong Wang, Regina Bones Barcellos, Fernanda M S Godinho, Richard Steiner Salvato, Aimee Ceniseros, Mallery I Breban, Nathan D Grubaugh, Glen R Gallagher, Chantal B F Vogels
The 2022 multicountry mpox outbreak concurrent with the ongoing Coronavirus Disease 2019 (COVID-19) pandemic further highlighted the need for genomic surveillance and rapid pathogen whole-genome sequencing. While metagenomic sequencing approaches have been used to sequence many of the early mpox infections, these methods are resource intensive and require samples with high viral DNA concentrations. Given the atypical clinical presentation of cases associated with the outbreak and uncertainty regarding viral load across both the course of infection and anatomical body sites, there was an urgent need for a more sensitive and broadly applicable sequencing approach...
June 2023: PLoS Biology
#34
JOURNAL ARTICLE
Lauren E O'Connor, Kevin D Hall, Kirsten A Herrick, Jill Reedy, Stephanie T Chung, Michael Stagliano, Amber B Courville, Rashmi Sinha, Neal D Freedman, Hyokyoung G Hong, Paul S Albert, Erikka Loftfield
BACKGROUND: Objective markers of ultraprocessed foods (UPF) may improve the assessment of UPF intake and provide insight into how UPF influences health. OBJECTIVES: To identify metabolites that differed between dietary patterns (DPs) high in or void of UPF according to Nova classification. METHODS: In a randomized, crossover, controlled-feeding trial (clinicaltrials.govNCT03407053), 20 domiciled healthy participants (mean ± standard deviation: age 31 ± 7 y, body mass index [kg/m2 ] 22 ± 11...
June 3, 2023: Journal of Nutrition
#35
JOURNAL ARTICLE
Kanishk Jain, Matthew R Marunde, Jonathan M Burg, Susan L Gloor, Faith M Joseph, Karl F Poncha, Zachary B Gillespie, Keli L Rodriguez, Irina K Popova, Nathan W Hall, Anup Vaidya, Sarah A Howard, Hailey F Taylor, Laylo Mukhsinova, Ugochi C Onuoha, Emily F Patteson, Spencer W Cooke, Bethany C Taylor, Ellen N Weinzapfel, Marcus A Cheek, Matthew J Meiners, Geoffrey C Fox, Kevin E W Namitz, Martis W Cowles, Krzysztof Krajewski, Zu-Wen Sun, Michael S Cosgrove, Nicolas Young, Michael-C Keogh, Brian D Strahl
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylation ( e.g. , K9ac, K14ac, K18ac) is linked to increased H3K4me3 engagement by the BPTF PHD finger, but it is unknown if this mechanism has broader extension. Here we show that H3 tail acetylation promotes nucleosomal accessibility to other H3K4 methyl readers, and importantly, extends to H3K4 writers, notably methyltransferase MLL1...
May 19, 2023: ELife
#36
JOURNAL ARTICLE
Tera L Fazzino, Amber B Courville, Juen Guo, Kevin D Hall
Diets for the prevention and treatment of obesity are often informed by theories about food characteristics believed to support spontaneous reductions in ad libitum energy intake without inducing hunger. Here we estimated how energy density, hyper-palatability, protein content and eating rate affected ad libitum energy intake of 2,733 meals from four dietary patterns. Energy density, eating rate and hyper-palatable foods were consistently positively related to meal energy intake across all diets. Protein content was positively related to meal energy intake during ultraprocessed and unprocessed diets but was not significantly related to energy intake of minimally processed low-fat or low-carbohydrate meals...
February 2023: Nature food
#37
JOURNAL ARTICLE
Wesley H Self, Matthew S Shotwell, Kevin W Gibbs, Marjolein de Wit, D Clark Files, Michelle Harkins, Kristin M Hudock, Lisa H Merck, Ari Moskowitz, Krystle D Apodaca, Aaron Barksdale, Basmah Safdar, Ali Javaheri, Jeffrey M Sturek, Harry Schrager, Nicole Iovine, Brian Tiffany, Ivor S Douglas, Joseph Levitt, Laurence W Busse, Adit A Ginde, Samuel M Brown, David N Hager, Katherine Boyle, Abhijit Duggal, Akram Khan, Michael Lanspa, Peter Chen, Michael Puskarich, Derek Vonderhaar, Lokesh Venkateshaiah, Nina Gentile, Yves Rosenberg, James Troendle, Amanda J Bistran-Hall, Josh DeClercq, Robert Lavieri, Meghan Morrison Joly, Michael Orr, Jill Pulley, Todd W Rice, Jonathan S Schildcrout, Matthew W Semler, Li Wang, Gordon R Bernard, Sean P Collins
IMPORTANCE: Preclinical models suggest dysregulation of the renin-angiotensin system (RAS) caused by SARS-CoV-2 infection may increase the relative activity of angiotensin II compared with angiotensin (1-7) and may be an important contributor to COVID-19 pathophysiology. OBJECTIVE: To evaluate the efficacy and safety of RAS modulation using 2 investigational RAS agents, TXA-127 (synthetic angiotensin [1-7]) and TRV-027 (an angiotensin II type 1 receptor-biased ligand), that are hypothesized to potentiate the action of angiotensin (1-7) and mitigate the action of the angiotensin II...
April 11, 2023: JAMA
#38
JOURNAL ARTICLE
Melania M Bembea, Laura L Loftis, Ravi R Thiagarajan, Cameron C Young, Timothy P McCadden, Margaret M Newhams, Suden Kucukak, Elizabeth H Mack, Julie C Fitzgerald, Courtney M Rowan, Aline B Maddux, Amanda R Kolmar, Katherine Irby, Sabrina Heidemann, Stephanie P Schwartz, Michele Kong, Hillary Crandall, Kevin M Havlin, Aalok R Singh, Jennifer E Schuster, Mark W Hall, Kari A Wellnitz, Mia Maamari, Mary G Gaspers, Ryan A Nofziger, Peter Paul C Lim, Ryan W Carroll, Alvaro Coronado Munoz, Tamara T Bradford, Melissa L Cullimore, Natasha B Halasa, Gwenn E McLaughlin, Pia S Pannaraj, Natalie Z Cvijanovich, Matt S Zinter, Bria M Coates, Steven M Horwitz, Charlotte V Hobbs, Heda Dapul, Ana Lia Graciano, Andrew D Butler, Manish M Patel, Laura D Zambrano, Angela P Campbell, Adrienne G Randolph
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) has been used successfully to support adults with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related cardiac or respiratory failure refractory to conventional therapies. Comprehensive reports of children and adolescents with SARS-CoV-2-related ECMO support for conditions, including multisystem inflammatory syndrome in children (MIS-C) and acute COVID-19, are needed. DESIGN: Case series of patients from the Overcoming COVID-19 public health surveillance registry...
May 1, 2023: Pediatric Critical Care Medicine
#39
JOURNAL ARTICLE
Rosario B Jaime-Lara, Alexis T Franks, Khushbu Agarwal, Nafisa Nawal, Amber B Courville, Juen Guo, Shanna Yang, Brianna E Brooks, Abhrarup Roy, Karen Taylor, Valerie L Darcey, James D LeCheminant, Stephanie Chung, Ciarán G Forde, Kevin D Hall, Paule V Joseph
Ultra-processed food consumption has increased world-wide, yet little is known about the potential links with taste preference and sensitivity. This exploratory study aimed to (i) compare sweet and salty taste detection thresholds and preferences following consumption of ultra-processed and unprocessed diets, (ii) investigate whether sweet and salty taste sensitivity and preference were associated with taste-substrates (i.e. sodium and sugar) and ad libitum nutrient intake, and (iii) examine associations of taste detection thresholds and preferences with blood pressure (BP) and anthropometric measures following consumption of ultra-processed and unprocessed diets...
March 10, 2023: Chemical Senses
#40
JOURNAL ARTICLE
Vojtěch Škop, Juen Guo, Naili Liu, Cuiying Xiao, Kevin D Hall, Oksana Gavrilova, Marc L Reitman
OBJECTIVE: Physical activity is a major component of total energy expenditure (TEE) that exhibits extreme variability in mice. Our objective was to construct a general, physiology-based model of TEE to accurately quantify the energy cost of physical activity. METHODS: Spontaneous home cage physical activity, body temperature, TEE, and energy intake were measured with frequent sampling. The energy cost of activity was modeled considering six contributors to TEE (basal metabolic rate, thermic effect of food, body temperature, cold induced thermogenesis, physical activity, and body weight)...
February 27, 2023: Molecular Metabolism
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