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https://www.readbyqxmd.com/read/28221107/use-of-mass-participation-outdoor-events-to-assess-human-exposure-to-tickborne-pathogens
#1
Jessica L Hall, Kathrin Alpers, Kevin J Bown, Stephen J Martin, Richard J Birtles
Mapping the public health threat of tickborne pathogens requires quantification of not only the density of infected host-seeking ticks but also the rate of human exposure to these ticks. To efficiently sample a high number of persons in a short time, we used a mass-participation outdoor event. In June 2014, we sampled ≈500 persons competing in a 2-day mountain marathon run across predominantly tick-infested habitat in Scotland. From the number of tick bites recorded and prevalence of tick infection with Borrelia burgdoferi sensu lato and B...
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28218409/development-of-haemostatic-decontaminants-for-treatment-of-wounds-contaminated-with-chemical-warfare-agents-3-evaluation-of-in-vitro-topical-decontamination-efficacy-using-damaged-skin
#2
Helen L Lydon, Charlotte A Hall, Christopher H Dalton, J Kevin Chipman, John S Graham, Robert P Chilcott
Previous studies have demonstrated that haemostatic products with an absorptive mechanism of action retain their clotting efficiency in the presence of toxic materials and are effective in decontaminating chemical warfare (CW) agents when applied to normal, intact skin. The purpose of this in vitro study was to assess three candidate haemostatic products for effectiveness in the decontamination of superficially damaged porcine skin exposed to the radiolabelled CW agents, soman (GD), VX and sulphur mustard (HD)...
February 20, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28206892/influence-of-the-amount-of-dentifrice-and-fluoride-concentrations-on-salivary-fluoride-levels-in-children
#3
Kevin Bruce Hall, Alberto Carlos Botazzo Delbem, Mariana Emi Nagata, Thayse Yumi Hosida, Felipe Ricardo Nunes de Moraes, Marcelle Danelon, Robson Frederico Cunha, Juliano Pelim Pessan
PURPOSE: This study evaluated fluoride (F) concentrations in saliva of children after brushing with dentifrices containing different F concentrations (zero, 550, and 1,100 ppm F) in different quantities (full bristles, transversal technique, and pea-sized). METHODS: Eight- to 10-year-old volunteers (<small>N</small>=24) were randomly assigned into nine experimental groups (dentifrice type versus amounts) following a double-blind, crossover protocol. After a one-week washout period (use of placebo toothpaste), stimulated saliva was collected prior to toothbrushing (baseline) and at five, 15, 30, 60, and 120 minutes after toothbrushing with one of the possible combinations...
October 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28193517/obesity-energetics-body-weight-regulation-and-the-effects-of-diet-composition
#4
Kevin D Hall, Juen Guo
Weight changes are accompanied by imbalances between calorie intake and expenditure. This fact is often misinterpreted to suggest that obesity is caused by gluttony and sloth and can be treated by simply advising people to eat less and move more. However, various components of energy balance are dynamically interrelated and weight loss is resisted by counterbalancing physiological processes. While low carbohydrate diets have been suggested to partially subvert these processes by increasing energy expenditure and promoting fat loss, our meta-analysis of 32 controlled feeding studies with isocaloric substitution of carbohydrate for fat found that both energy expenditure (26 kcal/d; p<0...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28169454/toxicity-of-sulfide-to-early-life-stages-of-wild-rice-zizania-palustris
#5
Douglas J Fort, Kevin Todhunter, Troy D Fort, Michael B Mathis, Rachel Walker, Mike Hansel, Scott Hall, Robin Richards, Kurt Anderson
Wild rice (Zizania palustris) sensitivity to sulfide is not well understood. Since sulfate in surface waters is reduced to sulfide by anaerobic bacteria in sediments and historical information indicated that 10 mg/L sulfate in Minnesota surface water reduced Z. palustris abundance, the Minnesota Pollution Control Agency (MPCA) established 10 mg/L sulfate as a water quality criterion in 1973. A 21-day daily-renewal hydroponic study was conducted to evaluate sulfide toxicity to wild rice and the potential mitigation of sulfide toxicity by Fe...
February 7, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28132905/towards-better-models-and-mechanistic-biomarkers-for-drug-induced-gastrointestinal-injury
#6
REVIEW
Daniel F Carr, Seyoum Ayehunie, Andrea Davies, Carrie A Duckworth, Stephanie French, Neil Hall, Syed Hussain, Howard R Mellor, Alan Norris, B Kevin Park, Alexander Penrose, D Mark Pritchard, Chris S Probert, Shashi Ramaiah, Claire Sadler, Michael Schmitt, Alison Shaw, James E Sidaway, Robert G Vries, Matthew Wagoner, Munir Pirmohamed
Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses a range of pathologies in different parts of the GI tract. However, to date no specific mechanistic diagnostic / prognostic biomarkers or translatable pre-clinical models of GI toxicity exist. This review will cover the current knowledge of GI ADRs, existing biomarkers and models with potential application for toxicity screening/ monitoring...
January 26, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28111149/increases-in-physical-activity-result-in-diminishing-increments-in-daily-energy-expenditure-in-mice
#7
Timothy J O'Neal, Danielle M Friend, Juen Guo, Kevin D Hall, Alexxai V Kravitz
Exercise is a common component of weight loss strategies, yet exercise programs are associated with surprisingly small changes in body weight [1-4]. This may be due in part to compensatory adaptations, in which calories expended during exercise are counteracted by decreases in other aspects of energy expenditure [1, 5-10]. Here we examined the relationship between a rodent model of voluntary exercise- wheel running- and total daily energy expenditure. Use of a running wheel for 3 to 7 days increased daily energy expenditure, resulting in a caloric deficit of ∼1 kcal/day; however, total daily energy expenditure remained stable after the first week of wheel access, despite further increases in wheel use...
February 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28048608/tu-e-tour-i-00-exhibit-hall-guided-tours-dosimters-for-qc-in-diagnostic-imaging-tuesday
#8
(no author information available yet)
: Tour Leader: Xia Jiang, Ohio State University, Columbus, OH Tour Guides: Xia Jiang, Ohio State University, Columbus, OH Kevin Little, The University of Chicago, Chicago, IL Christina Sammet, Lurie Children's Hospital of Chicago, Chicago, IL Participating Vendors: IBA PTW - New York Radcal Corporation RTI Electronics, Inc. Exhibit Hall Guided Tours is a new program launching this year at the Annual Meeting. The Guided Tours are designed to enhance the interaction between meeting attendees and exhibitors...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048432/we-c-tour-i-01-dosimters-for-qc-in-diagnostic-imaging
#9
X Jiang
: Tour Leader: Xia Jiang, Ohio State University, Columbus, OH Tour Guides: Xia Jiang, Ohio State University, Columbus, OH Kevin Little, The University of Chicago, Chicago, IL Adrien Sanchez, University of Chicago, Chicago, IL Participating Vendors: IBA PTW - New York Radcal Corporation RTI Electronics, Inc. Exhibit Hall Guided Tours is a new program launching this year at the Annual Meeting. The Guided Tours are designed to enhance the interaction between meeting attendees and exhibitors...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047940/tu-e-tour-i-01-dosimters-for-qc-in-diagnostic-imaging
#10
X Jiang
: Tour Leader: Xia Jiang, Ohio State University, Columbus, OH Tour Guides: Xia Jiang, Ohio State University, Columbus, OH Kevin Little, The University of Chicago, Chicago, IL Christina Sammet, Lurie Children's Hospital of Chicago, Chicago, IL Participating Vendors: IBA PTW - New York Radcal Corporation RTI Electronics, Inc. Exhibit Hall Guided Tours is a new program launching this year at the Annual Meeting. The Guided Tours are designed to enhance the interaction between meeting attendees and exhibitors...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046356/we-c-tour-i-00-exhibit-hall-guided-tours-dosimters-for-qc-in-diagnostic-imaging-wednesday
#11
(no author information available yet)
: Tour Leader: Xia Jiang, Ohio State University, Columbus, OH Tour Guides: Xia Jiang, Ohio State University, Columbus, OH Kevin Little, The University of Chicago, Chicago, IL Adrien Sanchez, University of Chicago, Chicago, IL Participating Vendors: IBA PTW - New York Radcal Corporation RTI Electronics, Inc. Exhibit Hall Guided Tours is a new program launching this year at the Annual Meeting. The Guided Tours are designed to enhance the interaction between meeting attendees and exhibitors...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041956/basal-ganglia-dysfunction-contributes-to-physical-inactivity-in-obesity
#12
Danielle M Friend, Kavya Devarakonda, Timothy J O'Neal, Miguel Skirzewski, Ioannis Papazoglou, Alanna R Kaplan, Jeih-San Liow, Juen Guo, Sushil G Rane, Marcelo Rubinstein, Veronica A Alvarez, Kevin D Hall, Alexxai V Kravitz
Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling contribute to physical inactivity in obesity. To investigate this, we quantified multiple aspects of dopamine signaling in lean and obese mice. We found that D2-type receptor (D2R) binding in the striatum, but not D1-type receptor binding or dopamine levels, was reduced in obese mice. Genetically removing D2Rs from striatal medium spiny neurons was sufficient to reduce motor activity in lean mice, whereas restoring Gi signaling in these neurons increased activity in obese mice...
February 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28027176/review-of-evaluation-of-the-propublica-surgeon-scorecard-adjusted-complication-rate-measure-specifications-by-ban-ka-cohen-me-ko-cy-friedberg-mw-stulberg-jj-zhou-l-hall-bl-hoyt-db-bilimoria-ky-in-ann-surg-264-566-574-2016
#13
https://www.readbyqxmd.com/read/28000663/robust-fractional-quantum-hall-effect-in-the-n-2-landau-level-in-bilayer-graphene
#14
Georgi Diankov, Chi-Te Liang, François Amet, Patrick Gallagher, Menyoung Lee, Andrew J Bestwick, Kevin Tharratt, William Coniglio, Jan Jaroszynski, Kenji Watanabe, Takashi Taniguchi, David Goldhaber-Gordon
The fractional quantum Hall effect is a canonical example of electron-electron interactions producing new ground states in many-body systems. Most fractional quantum Hall studies have focussed on the lowest Landau level, whose fractional states are successfully explained by the composite fermion model. In the widely studied GaAs-based system, the composite fermion picture is thought to become unstable for the N≥2 Landau level, where competing many-body phases have been observed. Here we report magneto-resistance measurements of fractional quantum Hall states in the N=2 Landau level (filling factors 4<|ν|<8) in bilayer graphene...
December 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27816499/effects-of-noise-exposure-on-young-adults-with-normal-audiograms-i-electrophysiology
#15
Garreth Prendergast, Hannah Guest, Kevin J Munro, Karolina Kluk, Agnès Léger, Deborah A Hall, Michael G Heinz, Christopher J Plack
Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies. In these animal models, the disorder is characterized by a reduction in amplitude of wave I of the auditory brainstem response (ABR) to high-level stimuli, whereas the response at threshold is unaffected. The aim of the present study was to determine if this disorder is prevalent in young adult humans with normal audiometric hearing. One hundred and twenty six participants (75 females) aged 18-36 were tested. Participants had a wide range of lifetime noise exposures as estimated by a structured interview...
February 2017: Hearing Research
https://www.readbyqxmd.com/read/27806966/contrasting-nav1-8-activity-in-scn10a-ventricular-myocytes-and-the-intact-heart
#16
Dina Myers Stroud, Tao Yang, Kevin Bersell, Dymtro O Kryshtal, Satomi Nagao, Christian Shaffer, Laura Short, Lynn Hall, Thomas C Atack, Wei Zhang, Bjorn C Knollmann, Franz Baudenbacher, Dan M Roden
BACKGROUND: Genome-wide association studies have implicated variants in SCN10A, which encodes Nav1.8, as modulators of cardiac conduction. Follow-up work has indicated the SCN10A sequence includes an intronic enhancer for SCN5A. Yet the role of the Nav1.8 protein in the myocardium itself is still unclear. To investigate this, we use homozygous knockout mice (Scn10a(-/-)) generated by disruption of exons 4 and 5, leaving the Scn5a enhancer intact. METHODS AND RESULTS: We previously reported that pharmacologic blockade of Nav1...
November 2, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27804272/how-strongly-does-appetite-counter-weight-loss-quantification-of-the-feedback-control-of-human-energy-intake
#17
David Polidori, Arjun Sanghvi, Randy J Seeley, Kevin D Hall
OBJECTIVE: To quantify the feedback control of energy intake in response to long-term covert manipulation of energy balance in free-living humans. METHODS: A validated mathematical method was used to calculate energy intake changes during a 52-week placebo-controlled trial in 153 patients treated with canagliflozin, a sodium glucose co-transporter inhibitor that increases urinary glucose excretion, thereby resulting in weight loss without patients being directly aware of the energy deficit...
November 2016: Obesity
https://www.readbyqxmd.com/read/27793119/obstetric-outcomes-for-women-with-female-genital-mutilation-at-an-australian-hospital-2006-2012-a-descriptive-study
#18
Nesrin Varol, Angela Dawson, Sabera Turkmani, John J Hall, Susie Nanayakkara, Greg Jenkins, Caroline S E Homer, Kevin McGeechan
BACKGROUND: Women, who have been subjected to female genital mutilation (FGM), can suffer serious and irreversible physical, psychological and psychosexual complications. They have more adverse obstetric outcomes as compared to women without FGM. Exploratory studies suggest radical change to abandonment of FGM by communities after migration to countries where FGM is not prevalent. Women who had been subjected to FGM as a child in their countries of origin, require specialised healthcare to reduce complications and further suffering...
October 28, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27765019/impact-of-rna-degradation-on-fusion-detection-by-rna-seq
#19
Jaime I Davila, Numrah M Fadra, Xiaoke Wang, Amber M McDonald, Asha A Nair, Barbara R Crusan, Xianglin Wu, Joseph H Blommel, Jin Jen, Kandelaria M Rumilla, Robert B Jenkins, Umut Aypar, Eric W Klee, Benjamin R Kipp, Kevin C Halling
BACKGROUND: RNA-seq is a well-established method for studying the transcriptome. Popular methods for library preparation in RNA-seq such as Illumina TruSeq® RNA v2 kit use a poly-A pulldown strategy. Such methods can cause loss of coverage at the 5' end of genes, impacting the ability to detect fusions when used on degraded samples. The goal of this study was to quantify the effects RNA degradation has on fusion detection when using poly-A selected mRNA and to identify the variables involved in this process...
October 20, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27753955/os-08-05-novel-molecular-insights-in-urinary-exosome-protein-profiling-in-thiazide-induced-hyponatremia
#20
Sarath Channavajjhala, Wenjing Jia, Mahli Jalland, Kevin OʼShaughnessy, Ian Hall, Mark Glover
OBJECTIVE: Thiazide diuretics are amongst most widely prescribed and effective anti-hypertensive medicines worldwide. Thiazides however cause Thiazide-Induced Hyponatremia (TIH), a novel and potentially important paradigm of dysregulated distal nephron sodium and water reabsorption. A priori TIH must result from excessive saliuresis and/or water reabsorption. The water and electrolyte transporter composition of Urinary Exosomes (UE) reflects their cellular origin and are a promising way to study renal dysfunction...
September 2016: Journal of Hypertension
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