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https://www.readbyqxmd.com/read/27816499/effects-of-noise-exposure-on-young-adults-with-normal-audiograms-i-electrophysiology
#1
Garreth Prendergast, Hannah Guest, Kevin J Munro, Karolina Kluk, Agnès Léger, Deborah A Hall, Michael G Heinz, Christopher J Plack
Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies. In these animal models, the disorder is characterized by a reduction in amplitude of wave I of the auditory brainstem response (ABR) to high-level stimuli, whereas the response at threshold is unaffected. The aim of the present study was to determine if this disorder is prevalent in young adult humans with normal audiometric hearing. One hundred and twenty six participants (75 females) aged 18-36 were tested. Participants had a wide range of lifetime noise exposures as estimated by a structured interview...
November 2, 2016: Hearing Research
https://www.readbyqxmd.com/read/27806966/contrasting-nav1-8-activity-in-scn10a-ventricular-myocytes-and-the-intact-heart
#2
Dina Myers Stroud, Tao Yang, Kevin Bersell, Dymtro O Kryshtal, Satomi Nagao, Christian Shaffer, Laura Short, Lynn Hall, Thomas C Atack, Wei Zhang, Bjorn C Knollmann, Franz Baudenbacher, Dan M Roden
BACKGROUND: Genome-wide association studies have implicated variants in SCN10A, which encodes Nav1.8, as modulators of cardiac conduction. Follow-up work has indicated the SCN10A sequence includes an intronic enhancer for SCN5A. Yet the role of the Nav1.8 protein in the myocardium itself is still unclear. To investigate this, we use homozygous knockout mice (Scn10a(-/-)) generated by disruption of exons 4 and 5, leaving the Scn5a enhancer intact. METHODS AND RESULTS: We previously reported that pharmacologic blockade of Nav1...
November 2, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27804272/how-strongly-does-appetite-counter-weight-loss-quantification-of-the-feedback-control-of-human-energy-intake
#3
David Polidori, Arjun Sanghvi, Randy J Seeley, Kevin D Hall
OBJECTIVE: To quantify the feedback control of energy intake in response to long-term covert manipulation of energy balance in free-living humans. METHODS: A validated mathematical method was used to calculate energy intake changes during a 52-week placebo-controlled trial in 153 patients treated with canagliflozin, a sodium glucose co-transporter inhibitor that increases urinary glucose excretion, thereby resulting in weight loss without patients being directly aware of the energy deficit...
November 2016: Obesity
https://www.readbyqxmd.com/read/27793119/obstetric-outcomes-for-women-with-female-genital-mutilation-at-an-australian-hospital-2006-2012-a-descriptive-study
#4
Nesrin Varol, Angela Dawson, Sabera Turkmani, John J Hall, Susie Nanayakkara, Greg Jenkins, Caroline S E Homer, Kevin McGeechan
BACKGROUND: Women, who have been subjected to female genital mutilation (FGM), can suffer serious and irreversible physical, psychological and psychosexual complications. They have more adverse obstetric outcomes as compared to women without FGM. Exploratory studies suggest radical change to abandonment of FGM by communities after migration to countries where FGM is not prevalent. Women who had been subjected to FGM as a child in their countries of origin, require specialised healthcare to reduce complications and further suffering...
October 28, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27765019/impact-of-rna-degradation-on-fusion-detection-by-rna-seq
#5
Jaime I Davila, Numrah M Fadra, Xiaoke Wang, Amber M McDonald, Asha A Nair, Barbara R Crusan, Xianglin Wu, Joseph H Blommel, Jin Jen, Kandelaria M Rumilla, Robert B Jenkins, Umut Aypar, Eric W Klee, Benjamin R Kipp, Kevin C Halling
BACKGROUND: RNA-seq is a well-established method for studying the transcriptome. Popular methods for library preparation in RNA-seq such as Illumina TruSeq® RNA v2 kit use a poly-A pulldown strategy. Such methods can cause loss of coverage at the 5' end of genes, impacting the ability to detect fusions when used on degraded samples. The goal of this study was to quantify the effects RNA degradation has on fusion detection when using poly-A selected mRNA and to identify the variables involved in this process...
October 20, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27753955/os-08-05-novel-molecular-insights-in-urinary-exosome-protein-profiling-in-thiazide-induced-hyponatremia
#6
Sarath Channavajjhala, Wenjing Jia, Mahli Jalland, Kevin OʼShaughnessy, Ian Hall, Mark Glover
OBJECTIVE: Thiazide diuretics are amongst most widely prescribed and effective anti-hypertensive medicines worldwide. Thiazides however cause Thiazide-Induced Hyponatremia (TIH), a novel and potentially important paradigm of dysregulated distal nephron sodium and water reabsorption. A priori TIH must result from excessive saliuresis and/or water reabsorption. The water and electrolyte transporter composition of Urinary Exosomes (UE) reflects their cellular origin and are a promising way to study renal dysfunction...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27716125/dars-a-phase-iii-randomised-multicentre-study-of-dysphagia-optimised-intensity-modulated-radiotherapy-do-imrt-versus-standard-intensity-modulated-radiotherapy-s-imrt-in-head-and-neck-cancer
#7
Imran Petkar, Keith Rooney, Justin W G Roe, Joanne M Patterson, David Bernstein, Justine M Tyler, Marie A Emson, James P Morden, Kathrin Mertens, Elizabeth Miles, Matthew Beasley, Tom Roques, Shreerang A Bhide, Kate L Newbold, Kevin J Harrington, Emma Hall, Christopher M Nutting
BACKGROUND: Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients' quality of life. Single arm studies have shown that the dosimetric sparing of critical swallowing structures such as the pharyngeal constrictor muscle and supraglottic larynx can translate to better functional outcomes. However, there are no current randomised studies to confirm the benefits of such swallow sparing strategies. The aim of Dysphagia/Aspiration at risk structures (DARS) trial is to determine whether reducing the dose to the pharyngeal constrictors with dysphagia-optimised intensity- modulated radiotherapy (Do-IMRT) will lead to an improvement in long- term swallowing function without having any detrimental impact on disease-specific survival outcomes...
October 6, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27670403/erratum-metabolic-adaptation-following-massive-weight-loss-is-related-to-the-degree-of-energy-imbalance-and-changes-in-circulating-leptin
#8
Nicolas D Knuth, Darcy L Johannsen, Robyn A Tamboli, Pamela A Marks-Shulman, Robert Huizenga, Kong Y Chen, Naji N Abumrad, Eric Ravussin, Kevin D Hall
No abstract text is available yet for this article.
October 2016: Obesity
https://www.readbyqxmd.com/read/27643350/os-08-05-novel-molecular-insights-in-urinary-exosome-protein-profiling-in-thiazide-induced-hyponatremia
#9
Sarath Channavajjhala, Wenjing Jia, Mahli Jalland, Kevin OʼShaughnessy, Ian Hall, Mark Glover
OBJECTIVE: Thiazide diuretics are amongst most widely prescribed and effective anti-hypertensive medicines worldwide. Thiazides however cause Thiazide-Induced Hyponatremia (TIH), a novel and potentially important paradigm of dysregulated distal nephron sodium and water reabsorption. A priori TIH must result from excessive saliuresis and/or water reabsorption. The water and electrolyte transporter composition of Urinary Exosomes (UE) reflects their cellular origin and are a promising way to study renal dysfunction...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27633460/personality-and-innate-immune-defenses-in-a-wild-bird-evidence-for-the-pace-of-life-hypothesis
#10
Rowan Jacques-Hamilton, Michelle L Hall, William A Buttemer, Kevin D Matson, Anders Gonҫalves da Silva, Raoul A Mulder, Anne Peters
We tested the two main evolutionary hypotheses for an association between immunity and personality. The risk-of-parasitism hypothesis predicts that more proactive (bold, exploratory, risk-taking) individuals have more vigorous immune defenses because of increased risk of parasite exposure. In contrast, the pace-of-life hypothesis argues that proactive behavioral styles are associated with shorter lifespans and reduced investment in immune function. Mechanistically, associations between immunity and personality can arise because personality differences are often associated with differences in condition and stress responsiveness, both of which are intricately linked with immunity...
September 12, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27597452/weight-loss-diet-studies-we-need-help-not-hype
#11
Yoni Freedhoff, Kevin D Hall
No abstract text is available yet for this article.
August 27, 2016: Lancet
https://www.readbyqxmd.com/read/27585837/brain-shift-in-neuronavigation-of-brain-tumors-a-review
#12
Ian J Gerard, Marta Kersten-Oertel, Kevin Petrecca, Denis Sirhan, Jeffery A Hall, D Louis Collins
PURPOSE: Neuronavigation based on preoperative imaging data is a ubiquitous tool for image guidance in neurosurgery. However, it is rendered unreliable when brain shift invalidates the patient-to-image registration. Many investigators have tried to explain, quantify, and compensate for this phenomenon to allow extended use of neuronavigation systems for the duration of surgery. The purpose of this paper is to present an overview of the work that has been done investigating brain shift...
August 24, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27581336/ibis-an-or-ready-open-source-platform-for-image-guided-neurosurgery
#13
Simon Drouin, Anna Kochanowska, Marta Kersten-Oertel, Ian J Gerard, Rina Zelmann, Dante De Nigris, Silvain Bériault, Tal Arbel, Denis Sirhan, Abbas F Sadikot, Jeffery A Hall, David S Sinclair, Kevin Petrecca, Rolando F DelMaestro, D Louis Collins
PURPOSE: Navigation systems commonly used in neurosurgery suffer from two main drawbacks: (1) their accuracy degrades over the course of the operation and (2) they require the surgeon to mentally map images from the monitor to the patient. In this paper, we introduce the Intraoperative Brain Imaging System (IBIS), an open-source image-guided neurosurgery research platform that implements a novel workflow where navigation accuracy is improved using tracked intraoperative ultrasound (iUS) and the visualization of navigation information is facilitated through the use of augmented reality (AR)...
August 31, 2016: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/27496740/effects-of-rearing-environment-on-the-gut-antimicrobial-responses-of-two-broiler-chicken-lines
#14
Vanessa L Butler, Catherine A Mowbray, Kevin Cadwell, Sherko S Niranji, Richard Bailey, Kellie A Watson, John Ralph, Judith Hall
To reduce the risk of enteric disease in poultry, knowledge of how bird gut innate defences mature with age while also responding to different rearing environments is necessary. In this study the gut innate responses of two phylogenetically distinct lines of poultry raised from hatch to 35days, in conditions mimicing high hygiene (HH) and low hygiene (LH) rearing environments, were compared. Analyses focussed on the proximal gut antimicrobial activities and the duodenal and caecal AvBD1, 4 and 10 defensin profiles...
October 1, 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27460247/screening-for-drugs-against-the-plasmodium-falciparum-digestive-vacuole-by-imaging-flow-cytometry
#15
Yan Quan Lee, Brian E Hall, Kevin S W Tan
Phenotypic assays are increasingly employed to provide clues about drug mechanisms. In antimalarial drug screening, however, the majority of assays are designed to only measure parasite-killing activity. We describe here a high-content assay to detect drug-mediated perturbation of the digestive vacuole integrity in the trophozoite stage of Plasmodium falciparum, using the ImageStream imaging flow cytometer.
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27456308/infant-mortality-cause-of-death-and-vital-records-reporting-in-ohio-united-states
#16
Laura M Seske, Louis J Muglia, Eric S Hall, Kevin E Bove, James M Greenberg
Introduction Infant mortality rate is a sensitive metric for population health and well-being. Challenges in achieving accurate reporting of these data can lead to inaccurate targeting of public health interventions. We analyzed a cohort from a pediatric tertiary care referral medical center to evaluate concordance between autopsy cause of death (COD) and death certificate documentation for infants <1 year of age. We predicted that infant COD as documented through vital records would not correspond to that as determined by autopsy...
July 25, 2016: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/27447721/impact-of-masked-replacement-of-sugar-sweetened-with-sugar-free-beverages-on-body-weight-increases-with-initial-bmi-secondary-analysis-of-data-from-an-18-month-double-blind-trial-in-children
#17
Martijn B Katan, Janne C de Ruyter, Lothar D J Kuijper, Carson C Chow, Kevin D Hall, Margreet R Olthof
BACKGROUND: Substituting sugar-free for sugar-sweetened beverages reduces weight gain. This effect may be more pronounced in children with a high body mass index (BMI) because their sensing of kilocalories might be compromised. We investigated the impact of sugar-free versus sugary drinks separately in children with a higher and a lower initial BMI z score, and predicted caloric intakes and degree of compensation in the two groups. METHODS AND FINDINGS: This is a secondary, explorative analysis of our double-blind randomized controlled trial (RCT) which showed that replacement of one 250-mL sugary drink per day by a sugar-free drink for 18 months significantly reduced weight gain...
2016: PloS One
https://www.readbyqxmd.com/read/27418041/trends-in-infective-endocarditis-hospitalisations-at-united-states-children-s-hospitals-from-2003-to-2014-impact-of-the-2007-american-heart-association-antibiotic-prophylaxis-guidelines
#18
Katherine E Bates, Matthew Hall, Samir S Shah, Kevin D Hill, Sara K Pasquali
OBJECTIVE: National organisations in several countries have recently released more restrictive guidelines for infective endocarditis prophylaxis, including the American Heart Association 2007 guidelines. Initial studies demonstrated no change in infective endocarditis rates over time; however, a recent United Kingdom study suggested an increase; current paediatric trends are unknown. METHODS: Children (5 years of age. Interrupted time series analysis was used to evaluate rates over time indexed to total hospitalisations...
July 15, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27385608/energy-expenditure-and-body-composition-changes-after-an-isocaloric-ketogenic-diet-in-overweight-and-obese-men
#19
Kevin D Hall, Kong Y Chen, Juen Guo, Yan Y Lam, Rudolph L Leibel, Laurel Es Mayer, Marc L Reitman, Michael Rosenbaum, Steven R Smith, B Timothy Walsh, Eric Ravussin
BACKGROUND: The carbohydrate-insulin model of obesity posits that habitual consumption of a high-carbohydrate diet sequesters fat within adipose tissue because of hyperinsulinemia and results in adaptive suppression of energy expenditure (EE). Therefore, isocaloric exchange of dietary carbohydrate for fat is predicted to result in increased EE, increased fat oxidation, and loss of body fat. In contrast, a more conventional view that "a calorie is a calorie" predicts that isocaloric variations in dietary carbohydrate and fat will have no physiologically important effects on EE or body fat...
August 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27365261/efficacy-and-safety-of-non-immersive-virtual-reality-exercising-in-stroke-rehabilitation-evrest-a-randomised-multicentre-single-blind-controlled-trial
#20
Gustavo Saposnik, Leonardo G Cohen, Muhammad Mamdani, Sepideth Pooyania, Michelle Ploughman, Donna Cheung, Jennifer Shaw, Judith Hall, Peter Nord, Sean Dukelow, Yongchai Nilanont, Felipe De Los Rios, Lisandro Olmos, Mindy Levin, Robert Teasell, Ashley Cohen, Kevin Thorpe, Andreas Laupacis, Mark Bayley
BACKGROUND: Non-immersive virtual reality is an emerging strategy to enhance motor performance for stroke rehabilitation. There has been rapid adoption of non-immersive virtual reality as a rehabilitation strategy despite the limited evidence about its safety and effectiveness. Our aim was to compare the safety and efficacy of virtual reality with recreational therapy on motor recovery in patients after an acute ischaemic stroke. METHODS: In this randomised, controlled, single-blind, parallel-group trial we enrolled adults (aged 18-85 years) who had a first-ever ischaemic stroke and a motor deficit of the upper extremity score of 3 or more (measured with the Chedoke-McMaster scale) within 3 months of randomisation from 14 in-patient stroke rehabilitation units from four countries (Canada [11], Argentina [1], Peru [1], and Thailand [1])...
September 2016: Lancet Neurology
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