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https://www.readbyqxmd.com/read/29775457/potassium-and-sodium-microdomains-in-thin-astroglial-processes-a-computational-model-study
#1
Kevin Breslin, John Joseph Wade, KongFatt Wong-Lin, Jim Harkin, Bronac Flanagan, Harm Van Zalinge, Steve Hall, Matthew Walker, Alexei Verkhratsky, Liam McDaid
A biophysical model that captures molecular homeostatic control of ions at the perisynaptic cradle (PsC) is of fundamental importance for understanding the interplay between astroglial and neuronal compartments. In this paper, we develop a multi-compartmental mathematical model which proposes a novel mechanism whereby the flow of cations in thin processes is restricted due to negatively charged membrane lipids which result in the formation of deep potential wells near the dipole heads. These wells restrict the flow of cations to "hopping" between adjacent wells as they transverse the process, and this surface retention of cations will be shown to give rise to the formation of potassium (K+) and sodium (Na+) microdomains at the PsC...
May 18, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29765742/crystal-structure-of-diaphorin-methanol-monosolvate-isolated-from-diaphorina-citri-kuwayama-the-insect-vector-of-citrus-greening-disease
#2
D Marian Szebenyi, Irina Kriksunov, Kevin J Howe, John S Ramsey, David G Hall, Michelle L Heck, Stuart B Krasnoff
The title compound C22 H39 NO9 ·CH3 OH [systematic name: ( S )- N -(( S )-{(2 S ,4 R ,6 R )-6-[( S )-2,3-di-hydroxy-prop-yl]-4-hy-droxy-5,5-di-methyl-tetra-hydro-2 H -pyran-2-yl}(hy-droxy)meth-yl)-2-hy-droxy-2-[(2 R ,5 R ,6 R )-2-meth-oxy-5,6-dimeth-yl-4-methyl-ene-tetra-hydro-2 H -pyran-2-yl]acetamide methanol monosolvate], was isolated from the Asian citrus psyllid, Diaphorina citri Kuwayama, and crystallizes in the space group P 21 . ' Candidatus Profftella armatura' a bacterial endosymbiont of D. citri , biosynthesizes diaphorin, which is a hybrid polyketide-nonribosomal peptide comprising two highly substituted tetra-hydro-pyran rings joined by an N -acyl aminal bridge [Nakabachi et al...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29758589/spindle-cell-rhabdomyosarcoma-of-bone-with-fus-tfcp2-fusion-confirmation-of-a-very-recently-described-rhabdomyosarcoma-subtype
#3
Nooshin K Dashti, Rebecca N Wehrs, Brittany C Thomas, Asha Nair, Jaime Davila, Jan C Buckner, Anthony P Martinez, William R Sukov, Kevin C Halling, Benjamin M Howe, Andrew L Folpe
AIMS: Rhabdomyosarcomas of bone are extremely rare, with fewer than 10 reported cases. A very rare subtype of spindle cell/sclerosing rhabdomyosarcoma harboring a FUS-TFCP2 fusion and involving both soft tissue and bone locations has very recently been reported. We report only the fourth case of this unusual, clinically aggressive rhabdomyosarcoma. MATERIAL AND RESULTS: A previously-well 72-year old male presented with a destructive lesion of the mandible. Morphological and immunohistochemical study of a needle biopsy and the subsequent resection showed a spindle cell rhabdomyosarcoma...
May 14, 2018: Histopathology
https://www.readbyqxmd.com/read/29754733/assessing-the-benefits-of-preoperative-thoracic-epidural-placement-for-lung-transplantation
#4
Sean R McLean, Peter von Homeyer, Aaron Cheng, Michael L Hall, Michael S Mulligan, Kevin Cain, Kei Togashi
OBJECTIVE: The authors investigated the effect of preoperative thoracic epidural (PreTE) catheter placement versus not placing a preoperative thoracic epidural catheter (NoPreTE) on the duration of postoperative ventilation time, time to become coherent (measured as time to become Confusion Assessment Method-intensive care unit [ICU] negative), opioid consumption, ICU length of stay (LOS), and hospital LOS. DESIGN: Retrospective cohort design. SETTING: Single institution, university hospital...
April 3, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29753519/state-of-the-national-emergency-department-workforce-who-provides-care-where
#5
M Kennedy Hall, Kevin Burns, Michael Carius, Mitchel Erickson, Jane Hall, Arjun Venkatesh
STUDY OBJECTIVE: We describe the current US emergency medicine workforce in terms of clinician type and examine rural and urban emergency medicine workforce differences. METHODS: Using the 2014 Medicare Public Use Files, we performed a cross-sectional study of all clinicians receiving reimbursement for evaluation and management (E/M) services (levels 1 to 5) to Medicare fee-for-service Part B beneficiaries in the emergency department. Providers were defined as emergency physicians, nonemergency physicians, or advanced practice providers, corresponding with the Medicare Public Use Files data set...
May 9, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29724785/p2y1-receptor-blockade-normalizes-network-dysfunction-and-cognition-in-an-alzheimer-s-disease-model
#6
Nicole Reichenbach, Andrea Delekate, Björn Breithausen, Kevin Keppler, Stefanie Poll, Theresa Schulte, Jan Peter, Monika Plescher, Jan N Hansen, Nelli Blank, Armin Keller, Martin Fuhrmann, Christian Henneberger, Annett Halle, Gabor C Petzold
Astrocytic hyperactivity is an important contributor to neuronal-glial network dysfunction in Alzheimer's disease (AD). We have previously shown that astrocyte hyperactivity is mediated by signaling through the P2Y1 purinoreceptor (P2Y1R) pathway. Using the APPPS1 mouse model of AD, we here find that chronic intracerebroventricular infusion of P2Y1R inhibitors normalizes astroglial and neuronal network dysfunction, as measured by in vivo two-photon microscopy, augments structural synaptic integrity, and preserves hippocampal long-term potentiation...
May 3, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29712793/a-systems-framework-for-national-assessment-of-climate-risks-to-infrastructure
#7
Richard J Dawson, David Thompson, Daniel Johns, Ruth Wood, Geoff Darch, Lee Chapman, Paul N Hughes, Geoff V R Watson, Kevin Paulson, Sarah Bell, Simon N Gosling, William Powrie, Jim W Hall
Extreme weather causes substantial adverse socio-economic impacts by damaging and disrupting the infrastructure services that underpin modern society. Globally, $2.5tn a year is spent on infrastructure which is typically designed to last decades, over which period projected changes in the climate will modify infrastructure performance. A systems approach has been developed to assess risks across all infrastructure sectors to guide national policy making and adaptation investment. The method analyses diverse evidence of climate risks and adaptation actions, to assess the urgency and extent of adaptation required...
June 13, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29677013/low-carbohydrate-diets-for-the-treatment-of-obesity-and-type-2-diabetes
#8
Kevin D Hall, Stephanie T Chung
PURPOSE OF REVIEW: Summarize the physiological effects of low-carbohydrate diets as they relate to weight loss, glycemic control, and metabolic health. RECENT FINDINGS: Low-carbohydrate diets are at least as effective for weight loss as other diets, but claims about increased energy expenditure and preferential loss of body fat are unsubstantiated. Glycemic control and hyperinsulinemia are improved by low-carbohydrate diets, but insulin sensitivity and glucose-stimulated insulin secretion may be impaired, especially in the absence of weight loss...
April 18, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29618054/influence-of-residual-disease-following-surgical-resection-in-newly-diagnosed-glioblastoma-on-clinical-neurocognitive-and-patient-reported-outcomes
#9
William A Hall, Stephanie L Pugh, Jeffrey S Wefel, Terri S Armstrong, Mark R Gilbert, David G Brachman, Maria Werner-Wasik, Merideth M Wendland, Paul D Brown, Samuel T Chao, Kevin S Roof, H Ian Robins, Minesh P Mehta, Walter J Curran, Benjamin Movsas
BACKGROUND: The influence of subtotal resection (STR) on neurocognitive function (NCF), quality of life, and symptom burden in glioblastoma is unknown. If bevacizumab preferentially benefits patients with STR is unknown. OBJECTIVE: To examine these uncertainties. METHODS: NCF and patient reported outcomes (PRO) were prospectively collected in NRG Oncology RTOG 0525 and 0825. Changes in NCF and PRO measures from baseline to prespecified times were examined by Wilcoxon test, and mixed effects longitudinal modeling, to assess differences between patients who received STR vs gross-total resection...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29575784/accumulating-data-to-optimally-predict-obesity-treatment-adopt-recommendations-from-the-biological-domain
#10
Michael Rosenbaum, Tanya Agurs-Collins, Molly S Bray, Kevin D Hall, Mark Hopkins, Maren Laughlin, Paul S MacLean, Padma Maruvada, Cary R Savage, Dana M Small, Luke Stoeckel
BACKGROUND: The responses to behavioral, pharmacological, or surgical obesity treatments are highly individualized. The Accumulating Data to Optimally Predict obesity Treatment (ADOPT) project provides a framework for how obesity researchers, working collectively, can generate the evidence base needed to guide the development of tailored, and potentially more effective, strategies for obesity treatment. OBJECTIVES: The objective of the ADOPT biological domain subgroup is to create a list of high-priority biological measures for weight-loss studies that will advance the understanding of individual variability in response to adult obesity treatments...
April 2018: Obesity
https://www.readbyqxmd.com/read/29575007/novel-organometallic-chloroquine-derivative-inhibits-tumor-growth
#11
Elizabeth A Hall, Jon E Ramsey, Zhihua Peng, Davit Hayrapetyan, Viacheslav Shkepu, Bruce O'Rourke, William Geiger, Kevin Lam, Claire F Verschraegen
Autophagy has emerged as a mechanism critical to both tumorigenesis and development of resistance to multiple lines of anti-cancer therapy. Therefore, targeting autophagy and alternative cell death pathways has arisen as a viable strategy for refractory tumors. The anti-malarial 4-aminoquinoline compounds chloroquine and hydroxychloroquine are currently being considered for re-purposing as anti-cancer therapies intended to sensitize different tumors by targeting the lysosomal cell death pathway. Here, we describe a novel organometallic chloroquine derivative, cymanquine, that exhibits enhanced bioactivity compared to chloroquine in both normal, and reduced pH tumor microenvironments, thus overcoming a defined limitation of traditional 4-aminoquinolines...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29562234/the-protein-histidine-phosphatase-lhpp-is-a-tumour-suppressor
#12
Sravanth K Hindupur, Marco Colombi, Stephen R Fuhs, Matthias S Matter, Yakir Guri, Kevin Adam, Marion Cornu, Salvatore Piscuoglio, Charlotte K Y Ng, Charles Betz, Dritan Liko, Luca Quagliata, Suzette Moes, Paul Jenoe, Luigi M Terracciano, Markus H Heim, Tony Hunter, Michael N Hall
Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized post-translational modification of proteins. Here we describe a role of histidine phosphorylation in tumorigenesis. Proteomic analysis of 12 tumours from an mTOR-driven hepatocellular carcinoma mouse model revealed that NME1 and NME2, the only known mammalian histidine kinases, were upregulated. Conversely, expression of the putative histidine phosphatase LHPP was downregulated specifically in the tumours. We demonstrate that LHPP is indeed a protein histidine phosphatase...
March 21, 2018: Nature
https://www.readbyqxmd.com/read/29541484/acute-on-chronic-subdural-hematoma-in-a-patient-taking-red-clover-herbal-supplement-a-case-report
#13
Samuel Hall, Eleanor Walshe, Claudia Ajayi, Kevin Boyle, Colin Griffith
Background: Herbal supplements are commonly used, however, their side-effect profiles are poorly understood and not subject to the same scrutiny as prescribed medications. Some herbal supplements such as St Johns' Wort are accepted to interfere with clotting pathways, however others, including Red Clover have theoretical bleeding risks based on coumarin content with very little underlying evidence. Case Description: This case reports a 65-year-old woman who suffered a spontaneous acute-on-chronic subdural hemorrhage with a significant postoperative re-hemorrhage...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29498036/yoda1-analogue-dooku1-which-antagonizes-yoda1-evoked-activation-of-piezo1-and-aortic-relaxation
#14
Elizabeth L Evans, Kevin Cuthbertson, Naima Endesh, Baptiste Rode, Nicola M Blythe, Adam J Hyman, Sally J Hall, Hannah J Gaunt, Melanie J Ludlow, Richard Foster, David J Beech
BACKGROUND AND PURPOSE: The mechanosensitive Piezo1 channel has important roles in vascular physiology and disease. Yoda1 is a small-molecule agonist, but the pharmacology of these channels is otherwise limited. EXPERIMENTAL APPROACH: Yoda1 analogues were generated by synthetic chemistry. Intracellular Ca2+ and Tl+ measurements were made in HEK 293 or CHO cell lines overexpressing channel subunits and in HUVECs, which natively express Piezo1. Isometric tension recordings were made from rings of mouse thoracic aorta...
May 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29490601/posterior-shoulder-tightness-to-treat-or-not-to-treat
#15
Kevin Hall, John D Borstad
Shoulder pain is a common musculoskeletal complaint that is difficult to treat because of the biomechanical complexity of the shoulder region, the interplay between mobility and stability, and the vital role played by the shoulder in moving, positioning, and providing stability for hand function. Despite advances in biomechanics and pain science, there is still much to learn about how impairments influence shoulder function and health. One impairment, posterior shoulder tightness (PST), is often noted in individuals with shoulder pain and consequently has generated much discussion and debate in recent years...
March 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29487063/age-trends-in-30-day-hospital-readmissions-us-national-retrospective-analysis
#16
Jay G Berry, James C Gay, Karen Joynt Maddox, Eric A Coleman, Emily M Bucholz, Margaret R O'Neill, Kevin Blaine, Matthew Hall
OBJECTIVE: To assess trends in and risk factors for readmission to hospital across the age continuum. DESIGN: Retrospective analysis. SETTING AND PARTICIPANTS: 31 729 762 index hospital admissions for all conditions in 2013 from the US Agency for Healthcare Research and Quality Nationwide Readmissions Database. MAIN OUTCOME MEASURE: 30 day, all cause, unplanned hospital readmissions. Odds of readmission were compared by patients' age in one year epochs with logistic regression, accounting for sex, payer, length of stay, discharge disposition, number of chronic conditions, reason for and severity of admission, and data clustering by hospital...
February 27, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29481241/observation-of-photonic-topological-valley-hall-edge-states
#17
Jiho Noh, Sheng Huang, Kevin P Chen, Mikael C Rechtsman
We experimentally demonstrate topological edge states arising from the valley-Hall effect in two-dimensional honeycomb photonic lattices with broken inversion symmetry. We break the inversion symmetry by detuning the refractive indices of the two honeycomb sublattices, giving rise to a boron nitridelike band structure. The edge states therefore exist along the domain walls between regions of opposite valley Chern numbers. We probe both the armchair and zigzag domain walls and show that the former become gapped for any detuning, whereas the latter remain ungapped until a cutoff is reached...
February 9, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29478781/biallelic-mutations-in-atp5f1d-which-encodes-a-subunit-of-atp-synthase-cause-a-metabolic-disorder
#18
Monika Oláhová, Wan Hee Yoon, Kyle Thompson, Sharayu Jangam, Liliana Fernandez, Jean M Davidson, Jennifer E Kyle, Megan E Grove, Dianna G Fisk, Jennefer N Kohler, Matthew Holmes, Annika M Dries, Yong Huang, Chunli Zhao, Kévin Contrepois, Zachary Zappala, Laure Frésard, Daryl Waggott, Erika M Zink, Young-Mo Kim, Heino M Heyman, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Michael Snyder, Jason D Merker, Stephen B Montgomery, Paul G Fisher, René G Feichtinger, Johannes A Mayr, Julie Hall, Ines A Barbosa, Michael A Simpson, Charu Deshpande, Katrina M Waters, David M Koeller, Thomas O Metz, Andrew A Morris, Susan Schelley, Tina Cowan, Marisa W Friederich, Robert McFarland, Johan L K Van Hove, Gregory M Enns, Shinya Yamamoto, Euan A Ashley, Michael F Wangler, Robert W Taylor, Hugo J Bellen, Jonathan A Bernstein, Matthew T Wheeler
ATP synthase, H+ transporting, mitochondrial F1 complex, δ subunit (ATP5F1D; formerly ATP5D) is a subunit of mitochondrial ATP synthase and plays an important role in coupling proton translocation and ATP production. Here, we describe two individuals, each with homozygous missense variants in ATP5F1D, who presented with episodic lethargy, metabolic acidosis, 3-methylglutaconic aciduria, and hyperammonemia. Subject 1, homozygous for c.245C>T (p.Pro82Leu), presented with recurrent metabolic decompensation starting in the neonatal period, and subject 2, homozygous for c...
March 1, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29477157/us-renal-data-system-2017-annual-data-report-epidemiology-of-kidney-disease-in-the-united-states
#19
EDITORIAL
Rajiv Saran, Bruce Robinson, Kevin C Abbott, Lawrence Y C Agodoa, Nicole Bhave, Jennifer Bragg-Gresham, Rajesh Balkrishnan, Xue Dietrich, Ashley Eckard, Paul W Eggers, Abduzhappar Gaipov, Daniel Gillen, Debbie Gipson, Susan M Hailpern, Yoshio N Hall, Yun Han, Kevin He, William Herman, Michael Heung, Richard A Hirth, David Hutton, Steven J Jacobsen, Yan Jin, Kamyar Kalantar-Zadeh, Alissa Kapke, Csaba P Kovesdy, Danielle Lavallee, Janet Leslie, Keith McCullough, Zubin Modi, Miklos Z Molnar, Maria Montez-Rath, Hamid Moradi, Hal Morgenstern, Purna Mukhopadhyay, Brahmajee Nallamothu, Danh V Nguyen, Keith C Norris, Ann M O'Hare, Yoshitsugu Obi, Christina Park, Jeffrey Pearson, Ronald Pisoni, Praveen K Potukuchi, Panduranga Rao, Kaitlyn Repeck, Connie M Rhee, Jillian Schrager, Douglas E Schaubel, David T Selewski, Sally F Shaw, Jiaxiao M Shi, Monica Shieu, John J Sim, Melissa Soohoo, Diane Steffick, Elani Streja, Keiichi Sumida, Manjula K Tamura, Anca Tilea, Lan Tong, Dongyu Wang, Mia Wang, Kenneth J Woodside, Xin Xin, Maggie Yin, Amy S You, Hui Zhou, Vahakn Shahinian
No abstract text is available yet for this article.
March 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29457381/a-multicenter-study-of-the-validity-and-reliability-of-responses-to-hand-cold-challenge-as-measured-by-laser-speckle-contrast-imaging-and-thermography-outcome-measures-for-systemic-sclerosis-related-raynaud-s-phenomenon
#20
Jack D Wilkinson, Sarah A Leggett, Elizabeth J Marjanovic, Tonia L Moore, John Allen, Marina E Anderson, Jason Britton, Maya H Buch, Francesco Del Galdo, Christopher P Denton, Graham Dinsdale, Bridgett Griffiths, Frances Hall, Kevin Howell, Audrey MacDonald, Neil J McHugh, Joanne B Manning, John D Pauling, Christopher Roberts, Jacqueline A Shipley, Ariane L Herrick, Andrea K Murray
OBJECTIVE: Reliable and objective outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) are badly needed. Laser speckle contrast imaging (LSCI) and thermography are noninvasive measures of perfusion that have shown excellent potential. This multicenter study was undertaken to determine the reliability and validity of a hand cold challenge protocol using LSCI, standard thermography, and low-cost cell phone/mobile phone thermography (henceforth referred to as mobile thermography) in patients with SSc-related RP...
February 18, 2018: Arthritis & Rheumatology
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