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Phenylephrine

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https://www.readbyqxmd.com/read/28213772/the-effect-of-purinergic-signaling-via-the-p2y11-receptor-on-vascular-function-in-a-rat-model-of-acute-inflammation
#1
Maria D Dănilă, Andreea Privistirescu, Oana M Duicu, Corina D Rațiu, Denis Angoulvant, Danina M Muntean, Adrian Sturza
There is a growing body of evidence pointing to the role of purinergic signaling in the development and progression of various conditions that have inflammation as a common pathogenetic denominator. The aim of the present study was to assess the involvement of P2Y11 purinergic receptors in the regulation of vascular function in aortic segments obtained using an experimental model of acute inflammation, the lipopolysaccharide (LPS, 8 mg/kg, i.p)-treated rats. Twelve hours after LPS administration, thoracic aortas were isolated and used for studies of vascular reactivity in the organ bath and for the measurement of reactive oxygen species (ROS) generation, respectively...
February 17, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28213289/quercetin-and-pioglitazone-synergistically-reverse-endothelial-dysfunction-in-isolated-aorta-from-fructose-streptozotocin-f-stz-induced-diabetic-rats
#2
Thubasni Kunasegaran, Mohd Rais Mustafa, Francis I Achike, Dharmani Devi Murugan
Pioglitazone is an anti-diabetic drug with potential to cause adverse effects following prolonged use. This study, therefore, investigated the effects of combination treatment of a subliminal concentration of pioglitazone and quercetin, a potent antioxidant, on vascular reactivity of aorta isolated from fructose-streptozotocin (F-STZ)-induced diabetic rats. Relaxation to acetylcholine and sodium nitroprusside, and contraction to phenylephrine were tested in organ bath chambers following pre-incubation with vehicle (DMSO; 0...
February 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28210543/changes-in-intraocular-pressure-and-horizontal-pupil-diameter-during-use-of-topical-mydriatics-in-the-canine-eye
#3
Liga Kovalcuka, Agris Ilgazs, Dace Bandere, David L Williams
The objective of this study was to determine the effects of topical 0.5% tropicamide, 1% atropine sulphate and 10% phenylephrine hydrochloride ophthalmic solutions on intraocular pressure (IOP) and horizontal pupil diameter (HPD) in the dog during the first hour after treatment. Forty clinically and ophthalmologically normal canine patients (between the ages of 2 and 6 years) of varying breed and sex were used in this study. Animals were randomly divided into four groups of ten and given one drop of tropicamide, atropine, phenylephrine or saline into one eye...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28209424/changes-in-sympathetic-neurovascular-function-following-spinal-cord-injury
#4
Hussain Al Dera, James A Brock
The effects of spinal cord injury (SCI) on sympathetic neurovascular transmission have generally been ignored. This review describes changes in sympathetic nerve-mediated activation of arterial vessels to which ongoing sympathetic activity has been reduced or silenced following spinal cord transection in rats. In all vessels studied in rats, SCI markedly enhanced their contractile responses to nerve activity. However, the mechanisms that augment neurovascular transmission differ between the rat tail artery and mesenteric artery...
February 11, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28208012/hypothermia-inhibits-endothelium-independent-vascular-contractility-via-rho-kinase-inhibition
#5
Yoon Hee Chung, Keon Woong Oh, Sung Tae Kim, Eon Sub Park, Hyun Dong Je, Hyuk-Jun Yoon, Uy Dong Sohn, Ji Hoon Jeong, Hyen-Oh La
The present study was undertaken to investigate the influence of hypothermia on endothelium-independent vascular smooth muscle contractility and to determine the mechanism underlying the relaxation. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Hypothermia significantly inhibited fluoride-, thromboxane A₂-, phenylephrine-, and phorbol ester-induced vascular contractions regardless of endothelial nitric oxide synthesis, suggesting that another pathway had a direct effect on vascular smooth muscle...
February 17, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28207427/progression-and-characterization-of-the-accelerated-atherosclerosis-in-iliac-artery-of-new-zealand-white-rabbits-effect-of-simvastatin
#6
Jitendra S Kanshana, Vivek Khanna, Vishal Singh, Manish Jain, Ankita Misra, Sachin Kumar, Mariya Farooqui, Manoj K Barthwal, Madhu Dikshit
OBJECTIVE: Although atherosclerosis is described in New Zealand White rabbit's iliac artery, yet details of time-dependent atherosclerosis progression are not well known. Further, a well characterized accelerated model of atherosclerosis is also required for the screening of candidate drugs to target specific steps of atherosclerosis development. The present study extensively characterizes the time-dependent plaque composition and functional responses of the atherosclerosis in rabbit iliac artery and its modification by simvastatin...
February 14, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28202248/possible-role-of-adrenoceptors-in-the-hypothalamic-paraventricular-nucleus-in-corticotropin-releasing-factor-induced-sympatho-adrenomedullary-outflow-in-rats
#7
Shoshiro Okada, Naoko Yamaguchi
AIMS: A functional interaction between the corticotropin-releasing factor (CRF) system and noradrenergic neurons in the brain has been suggested. In the present study, we investigated the interrelationship between the central CRF-induced elevation of plasma catecholamines and adrenoceptor activation in the paraventricular nucleus of the hypothalamus (PVN) using urethane-anesthetized rats. MAIN METHODS: In rats under urethane anesthesia, a femoral venous line was inserted for infusion of saline, and a femoral arterial line was inserted for collecting blood samples...
February 9, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28195341/left-ventricular-systolic-function-is-associated-to-sympathetic-nervous-activity-and-markers-of-inflammation-in-cirrhosis
#8
Raquel Yotti, Cristina Ripoll, Yolanda Benito, Maria Vega Catalina, Jaime Elízaga, Diego Rincón, Francisco Fernández-Avilés, Javier Bermejo, Rafael Bañares
: An accurate evaluation of cardiac function in patients with cirrhosis remains a challenge. We used robust echocardiographic indices to characterize LV systolic function and its relationship to activation of the sympathetic nervous system (SNS) and inflammation in 59 patients cirrhosis and 59 age-matched controls. Aditionally, in eleven patients we withdrew betablockers and diuretics and used phenylephrine and albumin infusion to evaluate the response to acute afterload and preload changes (interventional substudy)...
February 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28194469/phenylephrine-induced-cardiac-hypertrophy-is-attenuated-by-a-histone-acetylase-inhibitor-anacardic-acid-in-mice
#9
Chang Peng, Xiaomei Luo, Shuo Li, Huichao Sun
Cardiac hypertrophy is a complex process involving highly coordinated but tight regulation of multiple elements, such as in epigenetics, which make an important contribution to myocardium remodeling and cardiac hypertrophy. Epigenetic regulations, particularly histone acetylation, have been implicated in cardiac hypertrophy, however, the exact mechanism is still largely unknown. In the present study, we explored the potential attenuating effects of Chinese herbal extract anacardic acid on phenylephrine-induced cardiac hypertrophy and the underlying mechanism...
February 14, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28192751/ameliorative-potential-of-linagliptin-and-or-calcipotriol-on-bleomycin-induced-lung-fibrosis-in-vivo-and-in-vitro-study
#10
Ahmed M Kabel, Maaly A Abd Elmaaboud, Aliaa Atef, Mohammed H Baali
Pulmonary fibrosis is a serious medical problem that may significantly compromise respiratory functions. The aim of this work was to study the effect of linagliptin and/or calcipotriol on bleomycin-induced pulmonary fibrosis and to explore the possible mechanisms underlying this effect. One hundred and twenty male C57BL/6 mice were divided into 6 equal groups as follows: control group; bleomycin group; bleomycin+carboxymethylcellulose group; bleomycin+linagliptin group; bleomycin+calcipotriol group and bleomycin+linagliptin+calcipotriol group...
February 4, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28192151/angiotensin-1-7-dependent-vasorelaxation-of-the-renal-artery-exhibits-unique-angiotensin-and-bradykinin-receptor-selectivity
#11
Mariam H M Yousif, Ibrahim F Benter, Debra I Diz, Mark C Chappell
Angiotensin-(1-7) [Ang-(1-7)] exhibits blood pressure lowering actions, inhibits cell growth, and reduces tissue inflammation and fibrosis which may functionally antagonize an activated Ang II-AT1 receptor axis. Since the vascular actions of Ang-(1-7) and the associated receptor/signaling pathways varies in different vascular beds, the current study established the vasorelaxant properties of the heptapeptide in the renal artery of male Wistar male rats. Ang-(1-7) produced an endothelium-dependent vasodilator relaxation of isolated renal artery segments pre-contracted by a sub-maximal concentration of phenylephrine (PE) (10(-7)M)...
February 9, 2017: Peptides
https://www.readbyqxmd.com/read/28191756/aberrant-transforming-growth-factor-%C3%AE-activation-recruits-mesenchymal-stem-cells-during-prostatic-hyperplasia
#12
Long Wang, Liang Xie, Francis Tintani, Hui Xie, Changjun Li, Zhuang Cui, Mei Wan, Xiongbing Zu, Lin Qi, Xu Cao
Benign prostatic hyperplasia (BPH) is the overgrowth of prostate tissues with high prevalence in older men. BPH pathogenesis is not completely understood, but it is believed to be a result of de novo overgrowth of prostatic stroma. In this study, we show that aberrant activation of transforming growth factor-β (TGF-β) mobilizes mesenchymal/stromal stem cells (MSCs) in circulating blood, which are recruited for the prostatic stromal hyperplasia. Elevated levels of active TGF-β were observed in both a phenylephrine-induced prostatic hyperplasia mouse model and human BPH tissues...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28187467/protective-effects-of-ellagic-acid-on-cardiovascular-injuries-caused-by-hypertension-in-rats
#13
Juliana Bahia Reis Jordão, Hellen Karine Paes Porto, Flávio Marques Lopes, Aline Carvalho Batista, Matheus Lavorenti Rocha
Ellagic acid is described as having antioxidant and antiproliferative properties. Hence, it was hypothesized that ellagic acid could improve cardiovascular damage caused by hypertension. In this work, hypertension was induced in rats with Nω-Nitro-L-arginine methyl ester hydrochloride (60 mg/kg/day in drinking water) for 6 weeks. Ellagic acid was coadministered (10 or 30 mg/kg/day by gavage) between the second and sixth week. Blood pressure was recorded every week by tail-cuff plethysmography. After 6 weeks, the rats were sacrificed, the hearts and kidneys were weighed, and blood was collected...
February 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28183565/minimum-effective-fluid-volume-of-colloid-to-prevent-hypotension-during-caesarean-section-under-spinal-anesthesia-using-a-prophylactic-phenylephrine-infusion-an-up-down-sequential-allocation-study
#14
Christian Loubert, Pierre-Olivier Gagnon, Roshan Fernando
STUDY OBJECTIVE: The aim of this study was to de termine the minimum effective fluid volume (MEFV) of hydroxyethyl starch 130/0.4 (HES) infused in a preload fashion which would prevent hypotension in 50% of parturients undergoing caesarean section. A secondary objective was to measure the hemodynamic effect of fluid loading on the subjects. DESIGN: This is a prospective, double-blinded, dose-finding study using an up-down sequential allocation design. SETTING: In the operating room...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28181410/sestrin-1-ameliorates-cardiac-hypertrophy-via-autophagy-activation
#15
Ruicong Xue, Junyi Zeng, Yili Chen, Cong Chen, Weiping Tan, Jingjing Zhao, Bin Dong, Yu Sun, Yugang Dong, Chen Liu
Cardiac hypertrophy is one of the major risk factors of cardiovascular morbidity and mortality. Autophagy is acknowledged to be an important mechanism regulating cardiac hypertrophy. Sestrin 1, a downstream target gene of p53, has been proven to regulate autophagy. However, the role of Sestrin 1 in cardiac hypertrophy remains unknown. Our study showed that Sestrin 1 mRNA and protein expression declined in pressure overload cardiac hypertrophy and phenylephrine (PE)-induced cardiac hypertrophy. Knockdown of Sestrin 1 by RNAi deteriorated PE-induced cardiac hypertrophy, whereas the overexpression of Sestrin 1 by adenovirus transfection blunted hypertrophy...
February 9, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28164084/comparison-of-phenylephrine-and-ephedrine-in-treatment-of-spinal-induced-hypotension-in-high-risk-pregnancies-a-narrative-review
#16
REVIEW
Sasima Dusitkasem, Blair H Herndon, Monsicha Somjit, David L Stahl, Emily Bitticker, John C Coffman
PURPOSE: To compare maternal and fetal effects of intravenous phenylephrine and ephedrine administration during spinal anesthesia for cesarean delivery in high-risk pregnancies. SOURCE: An extensive literature search was conducted using the US National Library of Medicine, MEDLINE search engine, Cochrane review, and Google Scholar using search terms "ephedrine and phenylephrine," "preterm and term and spinal hypotension," "preeclampsia and healthy parturients," or "multiple and singleton gestation and vasopressor...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28163790/hypertrophy-changes-3d-shape-of-hipsc-cardiomyocytes-implications-for-cellular-maturation-in-regenerative-medicine
#17
Cassady E Rupert, Heidi H Chang, Kareen L K Coulombe
Advances in the use of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes for heart regeneration and in vitro disease models demand a greater understanding of how these cells grow and mature in 3-dimensional space. In this study, we developed an analysis methodology of single cardiomyocytes plated on 2D surfaces to assess their 3D myofilament volume and its z-height distribution, or shape, upon hypertrophic stimulation via phenylephrine (PE) treatment or long-term culture ("aging"). Cardiomyocytes were fixed and labeled with α-actinin for confocal microscopy imaging to obtain z-stacks for 3D myofilament volume analysis...
February 2017: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/28161542/vasorelaxation-effect-of-glycyrrhizae-uralensis-through-the-endothelium-dependent-pathway
#18
Chu Shan Tan, Yung Sing Ch'ng, Yean Chun Loh, Mohd Zaini Asmawi, Mariam Ahmad, Mun Fei Yam
ETHNOPHARMACOLOGICAL RELEVANCE: Glycyrrhiza uralensis (G. uralensis) is one of the herbs used in traditional Chinese medicine (TCM) and serves as an envoy medicinal. Since G. uralensis plays a major role in the anti-hypertensive TCM formulae, we believe that G. uralensis might possess vasorelaxation activity. AIM OF THE STUDY: This study is designed to investigate the vasorelaxation effect of G. uralensis from various extracts and to study its pharmacology effect...
February 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28159817/tissue-transglutaminase-modulates-vascular-stiffness-and-function-through-crosslinking-dependent-and-crosslinking-independent-functions
#19
Jochen Steppan, Yehudit Bergman, Kayla Viegas, Dinani Armstrong, Siqi Tan, Huilei Wang, Sean Melucci, Daijiro Hori, Sung Yong Park, Sebastian F Barreto, Abraham Isak, Sandeep Jandu, Nicholas Flavahan, Mark Butlin, Steven S An, Alberto Avolio, Dan E Berkowitz, Marc K Halushka, Lakshmi Santhanam
BACKGROUND: The structural elements of the vascular wall, namely, extracellular matrix and smooth muscle cells (SMCs), contribute to the overall stiffness of the vessel. In this study, we examined the crosslinking-dependent and crosslinking-independent roles of tissue transglutaminase (TG2) in vascular function and stiffness. METHODS AND RESULTS: SMCs were isolated from the aortae of TG2-/- and wild-type (WT) mice. Cell adhesion was examined by using electrical cell-substrate impedance sensing and PicoGreen assay...
February 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28149929/data-on-the-effects-of-losartan-on-protein-expression-vascular-reactivity-and-antioxidant-capacity-in-the-aorta-of-ethanol-treated-rats
#20
Carla S Ceron, Gabriel T do Vale, Janaina A Simplicio, Patrícia Passaglia, Sthefany T Ricci, Carlos R Tirapelli
We describe the effects of losartan, a selective AT1 receptor antagonist on the alterations induced by treatment with ethanol in the rat aorta. The data shown here are related to the article entitled "Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress" (P. Passaglia, C.S. Ceron, A.S. Mecawi, J. Antunes-Rodrigues, E.B. Coelho, C.R. Tirapelli, 2015) [1]. Here we include new data on the protective effect of losartan against ethanol-induced oxidative stress...
April 2017: Data in Brief
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