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https://www.readbyqxmd.com/read/28931752/l-dopa-sensitizes-vasomotor-tone-by-modulating-the-vascular-alpha1-adrenergic-receptor
#1
Daiki Masukawa, Motokazu Koga, Anna Sezaki, Yuka Nakao, Yuji Kamikubo, Tatsuo Hashimoto, Yuki Okuyama-Oki, Aderemi Caleb Aladeokin, Fumio Nakamura, Utako Yokoyama, Hiromichi Wakui, Hiroshi Ichinose, Takashi Sakurai, Satoshi Umemura, Koichi Tamura, Yoshihiro Ishikawa, Yoshio Goshima
Blood pressure is regulated by extrinsic factors including noradrenaline, the sympathetic neurotransmitter that controls cardiovascular functions through adrenergic receptors. However, the fine-tuning system of noradrenaline signaling is relatively unknown. We here show that l-3,4-dihydroxyphenylalanine (L-DOPA), a precursor of catecholamines, sensitizes the vascular adrenergic receptor alpha1 (ADRA1) through activation of L-DOPA receptor GPR143. In WT mice, intravenous infusion of the ADRA1 agonist phenylephrine induced a transient elevation of blood pressure...
September 21, 2017: JCI Insight
https://www.readbyqxmd.com/read/28929393/electrophysiological-characteristics-of-the-rat-azygos-vein-under-electrical-pacing-and-adrenergic-stimulation
#2
Alexandra D Ivanova, Vlad S Kuzmin
Rodent thoracic veins are characterized by an extended myocardial coating. In the present study, the electrical activity in the cardiac tissue of the rat azygos vein (AZV) was investigated for the first time. The atrial-like action potentials (AP) and atrial-like conduction of the excitation were observed in the rat AZV under continuous electrical pacing. Termination of electrical pacing resulted in spontaneous positive shift of resting membrane potential (RMP) in AZV. Boradrenaline induced biphasic effects on RMP in all quiescent AZV preparations but only in 25% preparations-bursts of spontaneous AP, which were suppressed by both α- and β-adrenoreceptor antagonists...
September 19, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28923249/akap-lbc-mediates-protection-against-doxorubicin-induced-cardiomyocyte-toxicity
#3
Stefania Caso, Darko Maric, Miroslav Arambasic, Susanna Cotecchia, Dario Diviani
Doxorubicin (DOX) is a chemotherapic agent that is widely used to treat hematological and solid tumors. Despite its efficacy, DOX displays significant cardiac toxicity associated with cardiomyocytes death and heart failure. Cardiac toxicity is mainly associated with the ability of DOX to alter mitochondrial function. The current lack of treatments to efficiently prevent DOX cardiotoxicity underscores the need of new therapeutic approaches. Our current findings show that stimulation of cardiomyocytes with the α1-adrenergic receptor (AR) agonist phenylephrine (PE) significantly inhibits the apoptotic effect of DOX...
September 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28917402/intracameral-mydriatics-versus-topical%C3%A2-mydriatics-in-pupil-dilation-for%C3%A2-phacoemulsification-cataract-surgery
#4
Amelia Lim Lay Suan, Jemaima Che Hamzah, Tan Soo Ken, Vanessa Naseem Mansurali
PURPOSE: To evaluate the efficacy and safety of intracameral mydriatics (lidocaine 1.0% and phenylephrine 1.5%) versus topical mydriatics (phenylephrine 2.5% and tropicamide 1.0%) in pupil dilation for phacoemulsification surgery in Malaysians. SETTING: Department of Ophthalmology, Penang General Hospital, Georgetown Penang, Malaysia. DESIGN: Prospective comparative case series. METHOD: Patients with immature cataract were randomized to the topical mydriatic group (topical group) or intracameral mydriatic group (intracameral group)...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28910549/upregulation-of-%C3%AE-enolase-protects-cardiomyocytes-from-phenylephrine-induced-hypertrophy
#5
Si Gao, Xueping Liu, Lihua Wei, Jing Lu, Peiqing Liu
Cardiac hypertrophy often refers to the abnormal growth of heart muscle through a variety of factors. The mechanisms of cardiomyocyte hypertrophy have been extensively investigated using neonatal rat cardiomyocytes treated with phenylephrine. α-Enolase is a glycolytic enzyme with "multifunctional jobs" beyond its catalytic activity. Its possible contribution to cardiac dysfunction remains to be determined. The present study aimed to investigate the change of α-enolase during cardiac hypertrophy and explore its role in this pathological process...
September 14, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28905113/influence-of-increased-heart-rate-and-aortic-pressure-on-resting-indices-of-functional-coronary-stenosis-severity
#6
Lorena Casadonte, Bart-Jan Verhoeff, Jan J Piek, Ed VanBavel, Jos A E Spaan, Maria Siebes
Baseline assessment of functional stenosis severity has been proposed as a practical alternative to hyperemic indices. However, intact autoregulation mechanisms may affect intracoronary hemodynamics. The aim of this study was to investigate the effect of changes in aortic pressure (Pa) and heart rate (HR) on baseline coronary hemodynamics and functional stenosis assessment. In 15 patients (55 ± 3% diameter stenosis) Pa, intracoronary pressure (Pd) and flow velocity were obtained at control, and during atrial pacing at 120 bpm, increased Pa (+30 mmHg) with intravenous phenylephrine (PE), and elevated Pa while pacing at sinus heart rate (PE + sHR)...
September 13, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28902432/c1q-tnf-related-protein-9-improves-the-anti-contractile-effects-of-perivascular-adipose-tissue-via-the-ampk-enos-pathway-in-diet-induced-obese-mice
#7
Fang Han, Yang Zhang, Mingxia Shao, Qingjie Mu, Xiaotong Jiao, Ningning Hou, Xiaodong Sun
The anti-contractile property of perivascular adipose tissue (PVAT) is abolished through an endothelium-dependent pathway in obesity. C1q/tumor necrosis factor-related protein (CTRP)9 improved endothelial function by promoting endothelium-dependent vasodilatation. The aims of this study were to investigate whether CTRP9 improves the anti-contractile effect of PVAT and protects against PVAT dysfunction in obese mice. The mice were treated with a high-fat diet with or without CTRP9 treatment. Thoracic aortas with or without PVAT (PVAT+ or PVAT-) were prepared, and concentration-dependent responses to phenylephrine were measured...
September 13, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28900851/tributyltin-chloride-disrupts-aortic-vascular-reactivity-and-increases-reactive-oxygen-species-production-in-female-rats
#8
Carolina Falcão Ximenes, Samya Mere Lima Rodrigues, Priscila Lang Podratz, Eduardo Merlo, Julia Fernandez Puñal de Araújo, Lívia Carla Melo Rodrigues, Juliana Barbosa Coitinho, Dalton Valentim Vassallo, Jones Bernardes Graceli, Ivanita Stefanon
Organotin compounds, such as tributyltin (TBT), are environment contaminants that induce bioaccumulation and have potential toxic effects on marine species and mammals. TBT have been banned by the International Maritime Organization in 2003. However, the assessment of butyltin and metal contents in marine sediments has demonstrated high residual levels of TBT in some cases exceeding 7000 ng Sn g(-1). The acceptable daily intake (ADI) level for TBT established by the World Health Organization is 0.5 μg/kg bw/day is based on genotoxicity, reproduction, teratogenicity, immunotoxicity, and mainly neurotoxicity...
September 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28899749/cyp4a-cyp2c-modulation-of-the-interaction-of-calcium-channel-blockers-with-cyclosporine-on-edhf-mediated-renal-vasodilations-in-rats
#9
Safaa H Hammoud, Amal G Omar, Assaad A Eid, Mahmoud M El-Mas
The endothelium-derived hyperpolarizing factor (EDHF) serves as a back-up mechanism that compensates for reduced nitric oxide (NO)/prostanoids bioavailability. Here we investigated whether (i) under conditions of vascular endothelium dysfunction, the immunosuppressant drug cyclosporine (CSA) upregulates EDHF-dependent renal vasodilations through altering CYP4A/CYP2C signaling, and (ii) calcium channel blockers modulate the CSA/EDHF/CYP interaction. Rats were treated with CSA, verapamil, nifedipine, or their combinations for 7days...
September 9, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28899735/a-randomised-comparison-of-bolus-phenylephrine-and-ephedrine-for-the-management-of-spinal-hypotension-in-patients-with-severe-preeclampsia-and-fetal-compromise
#10
R A Dyer, A Emmanuel, S C Adams, C J Lombard, M J Arcache, A Vorster, C A Wong, N Higgins, A R Reed, M F James, Y Joolay, S Schulein, D van Dyk
BACKGROUND: Studies in healthy patients undergoing elective caesarean delivery show that, compared with phenylephrine, ephedrine used to treat spinal hypotension is associated with increased fetal acidosis. This has not been investigated prospectively in women with severe preeclampsia. METHODS: Patients with preeclampsia requiring caesarean delivery for a non-reassuring fetal heart tracing were randomised to receive either bolus ephedrine (7.5-15mg) or phenylephrine (50-100µg), to treat spinal hypotension...
August 11, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28892640/beneficial-effects-of-rosiglitazone-and-losartan-combination-in-diabetic-rats
#11
Hayam Ateyya, Manar Nader, Nagla Ahmad El-Sherbeeny
Diabetes with vascular complication needs strict interventions to retard possible serious complications. This research estimated the possible interaction of rosiglitazone (RGN) with losartan (Los) in diabetic rats. Male Spraque Dawly rats were randomly divided into: non-diabetic rats, diabetic rats, and diabetic rats received RGN, Los or combination of RGN and Los. Measurement of serum glucose, vascular adhesion molecule-1 (VCAM-1), interleukin (IL)-6, tumor necrosis factor and (TNF)-α levels, and aortic lipid peroxide (MDA), glutathione (GSH), superoxide dismutase (SOD) and total nitrate/nitrite (NOx) levels were done...
September 11, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28887331/shock-and-lethality-with-anthrax-edema-toxin-in-rats-are-associated-with-reduced-arterial-responsiveness-to-phenylephrine-and-are-reversed-with-adefovir
#12
Dante Alexander Suffredini, Yan Li, Wanying Xu, Mahtab Moayeri, Stephen H Leppla, Yvonne Fitz, Xizhong Cui, Peter Q Eichacker
INTRODUCTION: Although edema (ETx) and lethal toxin (LTx) contribute to B. anthracis shock and lethality, mechanisms underlying their cardiovascular effects are unclear. We previously showed that ETx but not LTx inhibited phenylephrine stimulated contraction of aortic rings prepared from healthy rats and adefovir, a selective inhibitor of ETx cAMP production, blocked this effect. Here we examined arterial function in rats receiving 24h ETx or LTx infusions. METHODS AND RESULTS: Compared to controls, ETx reduced mean arterial pressure (MAP) and survival over 48h (p≤0...
September 8, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28885986/estimation-of-baroreflex-sensitivity-by-the-bivariate-phase-rectified-signal-averaging-method-a-comparison-with-the-phenylephrine-method
#13
Roberto Maestri, Maria Teresa La Rovere, Grzegorz Raczak, Ludmiła Danilowicz-Szymanowicz, Gian Domenico Pinna
Background A novel technique to assess spontaneous baroreflex sensitivity (BRS) by bivariate phase-rectified signal averaging (PRSA-BRS) has been recently proposed and its independent prognostic power demonstrated. This method, however, has never been compared with the Phenyleprine test (Phe-BRS), commonly regarded as the reference method in clinical and research applications. Methods In 192 heart failure (HF) and 41 post-myocardial infarction (post-MI) patients we compared PRSA-BRS with Phe-BRS, assessing both association and agreement...
September 8, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28882814/opsin-3-and-4-mediate-light-induced-pulmonary-vasorelaxation-that-is-potentiated-by-g-protein-receptor-kinase-2-inhibition
#14
Sebastian Barreto Ortiz, Daijiro Hori, Yohei Nomura, Xin Yun, Haiyang Jiang, Hwanmee Yong, James Chen, Sam Paek, Deepesh Pandey, Gautam Sikka, Anil Bhatta, Andrew Gillard, Jochen Steppan, Jae Hyung Kim, Hideo Adachi, Viachaslau Barodka, Lewis Romer, Steven S An, Larissa A Shimoda, Lakshmi Santhanam, Dan E Berkowitz
We recently demonstrated that blue light induces vasorelaxation in the systemic mouse circulation, a phenomenon mediated by the non-visual G protein-coupled receptor (GPCR) melanopsin (opsin 4; Opn4). Here we tested the hypothesis that non-visual opsins mediate photorelaxation in the pulmonary circulation. We discovered Opsin 3 (Opn3), Opn4, and G-protein coupled receptor kinase 2 (GRK2) in rat pulmonary arteries (PAs) and in pulmonary arterial smooth muscle cells (PASMCs), where the opsins interact directly with GRK2 as demonstrated with a proximity ligation assay...
September 7, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28877068/mc225-a-novel-probe-for-p-glycoprotein-pet-imaging-at-the-blood-brain-barrier-in-vitro-cardiovascular-safety-evaluation
#15
Fabio Fusi, Miriam Durante, Beatrice Gorelli, Maria Grazia Perrone, Colabufo Nicola Antonio, Simona Saponara
The P-glycoprotein (P-gp) substrate MC225, at concentrations ≤ 10 nM, is a valuable radiotracer for positron emission tomography (PET) imaging of P-gp function in rats and mice.The aim of this study was to evaluate its potential toxic hazard towards the cardiovascular system through an in-depth analysis of its effects on rat aorta rings, on CaV1.2 channel current (ICa1.2) of A7r5 cells and on Langendorff perfused rat heart.In aortic rings, MC225 relaxed phenylephrine-induced contraction in a concentration-dependent and endothelium-independent manner, with an IC50 value of about 1 µM...
September 1, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28872480/a-random-allocation-graded-dose-response-study-of-norepinephrine-and-phenylephrine-for-treating-hypotension-during-spinal-anesthesia-for-cesarean-delivery
#16
Warwick D Ngan Kee
BACKGROUND: Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of maternal heart rate and cardiac output. However, the relative potencies of these two vasopressors have not been fully determined in this context. METHODS: In a random-allocation, graded dose-response study, 180 healthy patients undergoing spinal anesthesia for elective cesarean delivery received a single bolus of norepinephrine in one of six different doses ranging from 4 to 12 µg or phenylephrine in one of six different doses ranging from 60 to 200 µg to treat the first episode of hypotension...
September 5, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28869322/attenuation-of-the-anti-contractile-effect-of-cooling-in-the-rat-aorta-by-perivascular-adipose-tissue
#17
Y Rafique, M AlBader, M Oriowo
In addition to providing mechanical support for blood vessels, the perivascular adipose tissue (PVAT) secretes a number of vasoactive substances and exerts an anticontractile effect. The main objective of this study was to find out whether the anticontractile effect of cooling in the rat aorta is affected by PVAT. Our hypothesis was that PVAT would enhance the anticontractile effect of cooling in the rat aorta. Aorta segments, with or without PVAT, were used in this investigation. Cumulative concentration-response curves were established for phenylephrine at 37°C or 24°C...
September 4, 2017: Autonomic & Autacoid Pharmacology
https://www.readbyqxmd.com/read/28868789/the-phenylephrine-concentration-response-relationship-for-blood-pressure-after-nasal-delivery-in-children
#18
Brian J Anderson, Lisa K Christensen, Valerie E Armstead, David P Bilyeu, Kenneth E Johnson, Robert H Friesen
BACKGROUND: Intranasal phenylephrine is commonly used to vasoconstrict the nasal mucosa, reducing bleeding associated with nasotracheal intubation or endoscopic sinus surgery. There are few data quantifying either absorption pharmacokinetics or phenylephrine concentration effect on blood pressure in children. METHODS: Published observations of plasma concentration and blood pressure changes after phenylephrine nasal administration (0.1 mL kg(-1) , 0.25% or 0.5%) in children (n = 52, 2-12 years, 10-40 kg) were pooled with those in adults (23-81 years) given phenylephrine 2...
September 4, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28864211/effects-of-spak-on-vascular-reactivity-and-nitric-oxide-production-in-endotoxemic-mice
#19
Chih-Chin Shih, Lin-Pin Hsu, Mei-Hui Liao, Sung-Sen Yang, Shung-Tai Ho, Chin-Chen Wu
Vasoplegia impedes therapeutic interventions to restore vascular tone, leading to severe hypotension, poor tissue perfusion, and multiple organ failure in septic shock. High levels of circulating nitric oxide (NO) play a crucial role in endotoxin-induced vascular hyporeactivity. Proinflammatory cytokines have been implicated in the induction of inducible NO synthase and overproduction of NO. Anti-inflammatory therapy can diminish NO formation and improve vascular hyporeactivity in septic shock. STE20/SPS1-realted proline/alanine-rich kinase (SPAK) has been reported to activate mitogen-activated protein kinase and contribute to intestinal inflammation...
August 29, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28862946/%C3%AE-1-adrenergic-receptors-function-within-hetero-oligomeric-complexes-with-atypical-chemokine-receptor-3-and-chemokine-c-x-c-motif-receptor-4-in-vascular-smooth-muscle-cells
#20
Lauren J Albee, Jonathan M Eby, Abhishek Tripathi, Heather M LaPorte, Xianlong Gao, Brian F Volkman, Vadim Gaponenko, Matthias Majetschak
BACKGROUND: Recently, we provided evidence that α1-adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C-X-C motif) receptor (CXCR) 4 and atypical chemokine receptor 3 (ACKR3). While we showed that CXCR4 controls α1-ARs through formation of heteromeric receptor complexes in human vascular smooth muscle cells (hVSMCs), the molecular basis underlying cross-talk between ACKR3 and α1-ARs is unknown. METHODS AND RESULTS: We show that ACKR3 agonists inhibit inositol trisphosphate production in hVSMCs on stimulation with phenylephrine...
August 17, 2017: Journal of the American Heart Association
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