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https://www.readbyqxmd.com/read/29140118/-11-c-choline-pet-ct-for-detection-and-localization-of-parathyroid-adenomas
#1
Ahmad Parvinian, Erica L Martin-Macintosh, Ajit H Goenka, Jolanta M Durski, Brian P Mullan, Brad J Kemp, Geoffrey B Johnson
OBJECTIVE: The purpose of this study is to determine the efficacy of (11)C-choline PET/CT for the detection of parathyroid adenomas by retrospectively reviewing a large patient population. MATERIALS AND METHODS: In this single-institution retrospective study, 7088 (11)C-choline PET/CT scans performed of 2933 men with prostate cancer from January 2005 through February 2016 were evaluated. Patients with suspected parathyroid adenomas were identified through a review of the electronic medical record and relevant imaging...
November 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29139142/safety-of-orally-administered-usp-compliant-levothyroxine-sodium-tablets-in-dogs
#2
J E Hare, C M K Morrow, J Caldwell, W E Lloyd
The safety of synthetic levothyroxine sodium tablets (Thyro-Tabs® Canine; LLOYD, Inc.) in dogs was evaluated in a randomized, sham-dose controlled, parallel-group study. Young, healthy, euthyroid Beagle dogs were randomized into four groups (four females and four males per group) and received single daily doses of 0×, 2× (0.044 mg/kg), 6× (0.132 mg/kg), or 10× (0.22 mg/kg) the labeled starting dose of 0.022 mg kg(-1)  day(-1) for 182 days. Every 2 weeks, physical examinations, electrocardiology examinations, and sample collections for thyroid panel, hematology, serum biochemistry, coagulation panel, and urinalysis were performed...
November 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29138914/impact-of-tailored-parathyroidectomy-for-treatment-of-primary-hyperparathyroidism-in-patients-with-multiple-endocrine-neoplasia-type-1
#3
Kiyomi Horiuchi, Momoko Sakurai, Kento Haniu, Erin Nagai, Hiroki Tokumitsu, Yusaku Yoshida, Yoko Omi, Akiko Sakamoto, Takahiro Okamoto
BACKGROUND: Whether total parathyroidectomy (TPTX) or subtotal parathyroidectomy (SPTX) should be performed for primary hyperparathyroidism (PHPT) in patients with multiple endocrine neoplasia type 1 (MEN1) is controversial. At our institution, the parathyroidectomy strategy is based on the number of enlarged intraoperative parathyroid glands. We retrospectively analyzed our parathyroidectomy procedures. METHODS: Data of PHPT treatment in patients with MEN1 who underwent parathyroidectomy from 1982 to 2012 at our department were retrospectively collected...
November 14, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29137892/role-of-pyrophosphate-in-vascular-calcification-in-chronic-kidney-disease
#4
Daniel Azpiazu, Sergio Gonzalo, Emilio González-Parra, Jesús Egido, Ricardo Villa-Bellosta
Vascular calcification is a pathology characterized by the deposition of calcium-phosphate in cardiovascular structures, mainly in the form of hydroxyapatite crystals, resulting in ectopic calcification. It is correlated with increased risk of cardiovascular disease and myocardial infarction in diabetic patients and in those with chronic kidney disease (CKD). Vascular smooth muscle cells are sensitive to changes in inorganic phosphate (Pi) levels. They are able to adapt and modify some of their functions and promote changes which trigger calcification...
November 11, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29136775/high-parathyroid-hormone-concentration-in-tenofovir-treated-patients-are-due-to-inhibition-of-calcium-sensing-receptor-activity
#5
Alessandra Mingione, Katia Maruca, Federica Chiappori, Francesca Pivari, Caterina Brasacchio, Tiziana Quirino, Ivan Merelli, Laura Soldati, Paolo Bonfanti, Stefano Mora
Bone health impairment is a common finding in HIV-infected patients on antiretroviral treatment. High serum parathyroid hormone (PTH) concentration in patients on antiretroviral treatment containing tenofovir disoproxil fumarate (TDF) has been reported. Hyperparathyroidism was not always sustained by a reduction in vitamin D concentration. We thus hypothesized a direct inhibitory effect of TDF on the Calcium-sensing receptor (CaSR), leading to hyperparathyroidism. Human embryonic kidney cells were transfected with CASR wild-type gene or mutated in different sites (N124K, T1051G, C788T, T888M)...
November 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136674/familial-hyperparathyroidism-disorders-of-growth-and-secretion-in-hormone-secretory-tissue
#6
Stephen J Marx, Delmar Muniz Lourenco
Six syndromes of familial hyperparathyroidism are compared: 1) Familial hypocalciuric hypercalcemia (FHH) expresses primary hyperparathyroidism (PHPT) beginning at birth with lifelong hypercalcemia. There is nonsuppressed PTH secretion from outwardly normal parathyroid glands. It reflects germline heterozygous mutation in CASR, GNA11, or AP2S1. 2) Neonatal severe primary hyperparathyroidism is severest of the six syndromes. It requires urgent total parathyroidectomy in infancy. It usually reflects biallelic inactivation of the CASR...
November 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29136400/changes-in-bone-turnover-and-calcium-homeostasis-during-pregnancy-and-lactation-in-mammals-a-meta-analysis
#7
Diego A Torres, Mariella B Freitas, Reggiani V Gonçalves
Large amounts of calcium are required during pregnancy and lactation to support fetal and neonatal bone growth and calcification. An inadequate supply of calcium during these stages can lead to unsuccessful reproduction or impaired offspring fitness. During reproduction, female mammals undergo numerous physiological changes, including adaptations to allow an adequate supply of calcium. The lack of quantitative studies analysing these physiological changes from a comparative perspective limits our ability to explain and understand these adaptations...
November 15, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29135297/-vitamin-d-and-calcium-supplementation-in-elderly-patients-with-hip-fracture
#8
Antal Salamon, Erzsébet Toldy, Csaba Biró, Ákos Mátrai, Tibor Balassa, Zoltán Lőcsei
Vitamin D plays an important role in maintaining calcium and bone metabolism, a risk factor of osteoporosis, fall and fracture in old age. Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important. Many authors publish their recommended doses used for prevention of hip fracture during the last years. Some authors are satisfied only with vitamin D supplementation while others have better experiences with vitamin D and calcium substitution...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29134690/faecal-calcium-excretion-does-not-decrease-during-long-term-feeding-of-a-low-calcium-diet-in-adult-dogs
#9
S Schmitt, J Mack, E Kienzle, L G Alexander, P J Morris, A Colyer, B Dobenecker
According to a previous meta-analysis, adult dogs do not notably increase calcium absorption from the gastrointestinal tract when calcium intake is decreased. This results in a negative calcium balance even with a moderate calcium reduction. In this study we wanted to verify (i) whether a negative calcium balance occurs at a calcium intake equivalent to NRC (2006) (Nutrient requirements of dogs and cats, 2006, The National Academies Press, Washington, DC) minimal requirements, and if so (ii) whether the negative calcium balance will persist for up to 6 months on a low-calcium diet...
November 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29134617/vascular-calcification-is-not-related-to-serum-fetuin-a-and-osteopontin-levels-in-hemodialysis-patients
#10
O Ulutas, M C Taskapan, A Dogan, T Baysal, H Taskapan
INTRODUCTION: Vascular calcification (VC) in hemodialysis (HD) patients is a sign of severe cardiovascular disease and can predict cardiovascular outcomes. Fetuin-A and osteopontin (OPN) inhibit VC. Serum fetuin-A levels are lower in patients with end-stage kidney disease (ESKD) and in those who are on chronic HD therapy. However, there are limited data concerning OPN in patients who are on dialysis. The aim of our study was to determine VC in HD patients, the relationship between VC and 25-OH-vitamin D, fetuin-A, and OPN levels, and independent predictors of VC...
November 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29134314/surgery-for-primary-hyperparathyroidism-with-normal-non-suppressed-parathyroid-hormone-can-be-both-challenging-and-successful
#11
Lauren E Orr, Travis J McKenzie, Geoffrey B Thompson, David R Farley, Robert A Wermers, Melanie L Lyden
BACKGROUND: Criteria for diagnosing primary hyperparathyroidism (PHPT) include hypercalcemia in the presence of parathyroid hormone (PTH) levels that are either elevated (classic PHPT) or normal but non-suppressed. However, there is no standard definition of what constitutes normal non-suppressed levels, and data are lacking regarding the potential for surgical cure in these patients. METHODS: A retrospective review of patients undergoing parathyroidectomy for sporadic PHPT between 2012 and 2014 was performed...
November 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29134242/serum-parathyroid-hormone-is-associated-with-increased-cortical-porosity-of-the-inner-transitional-zone-at-the-proximal-femur-in-postmenopausal-women-the-troms%C3%A3-study
#12
M Osima, T T Borgen, M Lukic, G Grimnes, R M Joakimsen, E F Eriksen, Å Bjørnerem
Serum parathyroid hormone (PTH) was associated with increased bone turnover markers and cortical porosity of the inner transitional zone at the proximal femur. These results suggest that PTH through increased intracortical bone turnover leads to trabecularisation of inner cortical bone in postmenopausal women. INTRODUCTION: Vitamin D deficiency leads to secondary hyperparathyroidism and increased risk for fractures, whereas its association with cortical porosity is less clear. We tested (i) whether serum 25-hydroxyvitamin D (25(OH)D) and PTH were associated with cortical porosity and (ii) whether the associations of 25(OH)D) and PTH with fracture risk are dependent on cortical porosity...
November 14, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29133077/-chronic-kidney-failure-and-biotin-a-combination-inducing-unusual-results-in-thyroid-and-parathyroid-investigations-report-of-2-cases
#13
Miora Koloina Ranaivosoa, Sébastien Ganel, Arnaud Agin, Sarah Romain, Xavier Parent, Nathalie Reix
In clinical chemistry, many immunoassays apply biotin and streptavidin in the assay principle. Presence of high levels of biotin in patient samples can produce negative or positive interference depending on the assay format. In this study, we describe 2 clinical cases with chronic kidney failure and with unusual thyroid and parathyroid function test results due to biotin interference. We studied the impact of biotin levels on thyroid stimulating hormone (TSH), free thyroxine (T4L) and parathormone (PTH) results with a pool of sera loaded with several concentrations of biotin...
November 10, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29132721/endocrine-pathology-past-present-and-future
#14
REVIEW
Sylvia L Asa, Ozgur Mete
Endocrine pathology is the subspecialty of diagnostic pathology which deals with the diagnosis and characterisation of neoplastic and non-neoplastic diseases of the endocrine system. This relatively young subspecialty was initially focused mainly on thyroid and parathyroid pathology, with some participants also involved in studies of the pituitary, the endocrine pancreas, and the adrenal glands. However, the endocrine system involves much more than these traditional endocrine organs and the discipline has grown to encompass lesions of the dispersed neuroendocrine cells, including neuroendocrine tumours (NETs) of the lungs, gastrointestinal tract, thymus, breast and prostate, as well as paraganglia throughout the body, not just in the adrenals...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29131865/associations-between-ret-tagsnps-and-their-haplotypes-and-susceptibility-clinical-severity-and-thyroid-function-in-patients-with-differentiated-thyroid-cancer
#15
Caiyun He, Jiangjun Ma, Yongle Jiang, Xuan Su, Xiao Zhang, Weichao Chen, Zulu Ye, Tiancheng Deng, Wenze Deng, Ankui Yang
BACKGROUND: It is unclear whether common genetic variants of the RET proto-oncogene contribute to disease susceptibility, clinical severity, and thyroid function in differentiated thyroid cancer (DTC). METHODS: A total of 300 DTC patients and 252 healthy controls were enrolled in this study. Seven RET tagging single nucleotide polymorphisms were genotyped using the KASPar platform. RESULTS: Subgroup analysis showed that concomitant thyroid benign diseases were less likely to occur in DTC subjects with the rs1799939 AG or AG plus AA genotypes (odds ratio (OR) = 1...
2017: PloS One
https://www.readbyqxmd.com/read/29131092/value-of-intraoperative-parathyroid-hormone-assay-during-parathyroidectomy-in-dialysis-and-renal-transplant-patients-with-secondary-and-tertiary-hyperparathyroidism
#16
Amr El-Husseini, Kevin Wang, Annick Edon, David Saxon, Florence Lima, David Sloan, B Peter Sawaya
BACKGROUND: In dialysis and renal transplant patients with secondary and tertiary hyperparathyroidism (HPT), the value of intraoperative parathyroid hormone (ioPTH) during parathyroidectomy (PTX) and its association with long-term PTH levels are unknown. The present study aims at evaluating the relationship of ioPTH with long-term PTH levels post-PTX in dialysis and renal transplant patients in a single-center study. METHODS: The ioPTH was measured in 57 dialysis patients (33 females and 24 males) and 18 renal transplant recipients (12 males and 6 females) who underwent PTX from 2005 to 2015 for refractory HPT...
November 9, 2017: Nephron
https://www.readbyqxmd.com/read/29130559/effect-of-general-anesthesia-and-intubation-on-parathyroid-levels-in-normal-patients-and-those-with-hyperparathyroidism
#17
Udi Cinamon, Doron Gavish, Sharon Ovnat Tamir, Abraham Goldfarb, Tiberiu Ezri
BACKGROUND: Induction of general anesthesia and endotracheal intubation may precipitate parathyroid hormone (PTH) elevation in patients with primary hyperparathyroidism (HPT). The purposes of this study were to revisit this observation and to study its impact in healthy patients. METHODS: Patients with primary HPT who underwent parathyroidectomy were retrospectively studied. The PTH was sampled and compared: before, immediately after general anesthesia and endotracheal intubation, and 15 minutes after parathyroidectomy...
November 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/29129358/indocyanine-green-fluorescence-guided-parathyroidectomy-for-primary-hyperparathyroidism
#18
Jonathan C DeLong, Erin P Ward, Thinzar M Lwin, Kevin T Brumund, Kaitlyn J Kelly, Santiago Horgan, Michael Bouvet
BACKGROUND: Our aim was to evaluate the ease and utility of using indocyanine green fluorescence angiography for intraoperative localization of the parathyroid glands. METHODS: Indocyanine green fluorescence angiography was performed during 60 parathyroidectomies for primary hyperparathyroidism during a 22-month period. Indocyanine green was administered intravenously to guide operative navigation using a commercially available fluorescence imaging system. Video files were graded by 3 independent surgeons for strength of enhancement using an adapted numeric scoring system...
November 9, 2017: Surgery
https://www.readbyqxmd.com/read/29128315/parathyroid-hormone-calcidiol-calcitriol-and-adverse-events-in-the-acute-coronary-syndrome
#19
P Ramos Ruiz, L Jaulent Huertas, M Castañeda Sancirilo, J J Martínez Díaz, G Clavel Ruipérez, L García de Guadiana Romualdo, S Wasniewski, M Merelo Nicolás, I García Escribano, F Soria Arcos, J A Castillo Moreno, L Consuegra Sánchez
OBJECTIVE: To know the clinical profile as well as the prognostic significance of elevated levels of parathyroid hormone (PTH) in patients admitted for acute coronary syndrome (ACS). DESIGN AND SETTING: Observational and prospective study of patients admitted for ACS in a single Spanish center during a period of six months. INTERVENTION AND VARIABLES OF INTEREST: The circulating concentrations of PTH, calcidiol, calcitriol, NT-proBNP, C-reactive protein, cystatinC and fibrinogen were determined within the first 48h at admission...
November 8, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29128188/influence-of-concurrent-chronic-kidney-disease-on-intraoperative-parathyroid-hormone-monitoring-during-parathyroidectomy-for-primary-hyperparathyroidism
#20
Bipin Sunkara, Mark S Cohen, Barbra S Miller, Paul G Gauger, David T Hughes
BACKGROUND: The influence of chronic kidney disease on intraoperative parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism has not been well-established. We hypothesize that chronic kidney disease influences intraoperative parathyroid hormone degradation kinetics during parathyroidectomy. METHODS: This is a single institution retrospective cohort study of consecutive patients with primary hyperparathyroidism underdoing parathyroidectomy...
November 8, 2017: Surgery
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