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https://www.readbyqxmd.com/read/28817621/re-evaluation-of-the-cost-effectiveness-and-effects-of-childhood-rotavirus-vaccination-in-norway
#1
Christina Hansen Edwards, Birgitte Freiesleben de Blasio, Beatriz Valcárcel Salamanca, Elmira Flem
BACKGROUND: Rotavirus vaccination was included into the Norwegian childhood immunisation programme in 2014. Before implementation, rotavirus vaccination was found to be cost-effective from a societal perspective, but not from a healthcare perspective. Since introduction, new data on the incidence and economic effects of rotavirus disease have become available. We assessed early epidemiological effects of the rotavirus vaccination programme and re-evaluated its cost-effectiveness in Norway for the years 2015-2019...
2017: PloS One
https://www.readbyqxmd.com/read/28817241/association-between-vitamin-d-deficiency-and-heart-failure-risk-in-the-elderly
#2
Catarina Magalhães Porto, Vanessa De Lima Silva, João Soares Brito da Luz, Brivaldo Markman Filho, Vera Magalhães da Silveira
AIMS: The aim of this study was to evaluate the association between vitamin D deficiency and risk of heart failure in elderly patients of cardiology outpatient clinics. METHODS AND RESULTS: A cross-sectional study with an analytical approach was employed. Clinical data were collected from the elderly from August 2015 to February 2016. The dependent variable was the risk of heart failure; the independent variable was vitamin D deficiency; and intervening factors were age, gender, education, ethnicity, hypertension, diabetes mellitus, hypothyroidism, renal failure, dementia, stroke, dyslipidaemia, depression, smoking, alcoholism, obesity, andropause, and cardiac arrhythmia...
August 17, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28817233/evaluation-and-quantitative-analysis-of-11-compounds-in-morinda-officinalis-using-ultra-high-performance-liquid-chromatography-and-photodiode-array-detection-coupled-with-chemometrics
#3
Xiangsheng Zhao, Weijun Kong, Yakui Zhou, Jianhe Wei, Meihua Yang
Morinda officinalis (Rubiaceae) is a traditional Chinese medicine widely used for the treatment of impotence and osteoporosis in clinical therapy. In the present study, a rapid and simple ultra high performance liquid chromatography with photodiode array detection method was developed and validated for the simultaneous determination of 11 bioactive compounds in M. officinalis. This assay method was validated with respect to linearity (R(2)( ) > 0.9991), precision, repeatability, limit of detection, limit of quantification, and accuracy (with observed recovery rates between 94...
August 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28817075/discrimination-of-transgenic-maize-kernel-using-nir-hyperspectral-imaging-and-multivariate-data-analysis
#4
Xuping Feng, Yiying Zhao, Chu Zhang, Peng Cheng, Yong He
There are possible environmental risks related to gene flow from genetically engineered organisms. It is important to find accurate, fast, and inexpensive methods to detect and monitor the presence of genetically modified (GM) organisms in crops and derived crop products. In the present study, GM maize kernels containing both cry1Ab/cry2Aj-G10evo proteins and their non-GM parents were examined by using hyperspectral imaging in the near-infrared (NIR) range (874.41-1733.91 nm) combined with chemometric data analysis...
August 17, 2017: Sensors
https://www.readbyqxmd.com/read/28816500/research-challenges-in-financial-data-modeling-and-analysis
#5
Lewis Alexander, Sanjiv R Das, Zachary Ives, H V Jagadish, Claire Monteleoni
Significant research challenges must be addressed in the cleaning, transformation, integration, modeling, and analytics of Big Data sources for finance. This article surveys the progress made so far in this direction and obstacles yet to be overcome. These are issues that are of interest to data-driven financial institutions in both corporate finance and consumer finance. These challenges are also of interest to the legal profession as well as to regulators. The discussion is relevant to technology firms that support the growing field of FinTech...
August 17, 2017: Big Data
https://www.readbyqxmd.com/read/28815681/meta-analytical-synthesis-of-regression-coefficients-under-different-categorization-scheme-of-continuous-covariates
#6
Daisuke Yoneoka, Masayuki Henmi
Recently, the number of clinical prediction models sharing the same regression task has increased in the medical literature. However, evidence synthesis methodologies that use the results of these regression models have not been sufficiently studied, particularly in meta-analysis settings where only regression coefficients are available. One of the difficulties lies in the differences between the categorization schemes of continuous covariates across different studies. In general, categorization methods using cutoff values are study specific across available models, even if they focus on the same covariates of interest...
August 16, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28815446/a-human-pet-study-of-11-c-hms011-a-potential-radioligand-for-ampa-receptors
#7
Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masaki Tokunaga, Masanori Ichise, Kazunori Kawamura, Maiko Ono, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishii, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Yoko Ikoma, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
BACKGROUND: α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases. We recently developed a novel positron emission tomography (PET) ligand, 2-(1-(3-([(11)C]methylamino)phenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl) benzonitrile ([(11)C]HMS011). This compound is a radiolabelled derivative of perampanel, an antiepileptic drug acting on AMPA receptors, and was demonstrated to have promising in vivo properties in the rat and monkey brains...
August 16, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28815110/development-of-a-framework-for-large-scale-three-dimensional-pathology-and-biomarker-imaging-and-spatial-analytics
#8
Yanhui Liang, Fusheng Wang, Pengyue Zhang, Joel H Saltz, Daniel J Brat, Jun Kong
With the rapid advancement in large-throughput scanning technologies, digital pathology has emerged as platform with promise for diagnostic approaches, but also for high-throughput quantitative data extraction and analysis for translational research. Digital pathology and biomarker images are rich sources of information on tissue architecture, cell diversity and morphology, and molecular pathway activation. However, the understanding of disease in three-dimension (3D) has been hampered by their traditional two-dimension (2D) representations on histologic slides...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28814174/the-patient-centered-care-and-receipt-of-preventive-services-among-older-adults-with-chronic-diseases-a-nationwide-cross-sectional-study
#9
Hailun Liang, Junya Zhu, Xiangrong Kong, May A Beydoun, Jennifer A Wenzel, Leiyu Shi
This article investigates the associations between the patient-centered care (PCC) and receipt of preventive services among older adults with chronic diseases. Data were derived from the nationally representative Medical Expenditure Panel Survey. The full-year consolidated data files from 2009 to 2013 were pooled to yield a final analytic sample (N = 16 654). Study outcomes included the receipt of 7 types of preventive screenings and 2 types of health education services. Patients' PCC groups were categorized as PCC, partial PCC, and non-PCC, based on 9 questions classified under the 3 distinctive attributes of PCC-whole-person care, patient engagement, and enhanced access to care...
January 1, 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/28814125/recreational-drug-use-at-a-major-music-festival-trend-analysis-of-anonymised-pooled-urine
#10
Lotte Christine Groth Hoegberg, Cecilie Christiansen, Jesper Soe, Rasmus Telving, Mette Findal Andreasen, Dan Staerk, Lona Louring Christrup, Kenneth Thermann Kongstad
OBJECTIVE: The spread of new psychoactive substances (NPS) has expanded rapidly in the last decade. The complexity of the pharmacological effects of NPS challenges the traditional treatment guidelines, and information of the emergence of new arrivals is valuable. Our knowledge on the actual range of recreational drugs used and NPS available in Denmark is limited as identification is possible only when consumers become patients in the healthcare system or through drug seizures. We aimed to detect classical recreational drugs and NPS in the urine of music festival attendees and evaluate if the use of NPS could have been predicted by comparing study data with drug seizure data from the previous year published by European and Danish health authorities...
August 17, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28813537/metabolite-patterns-predicting-sex-and-age-in-participants-of-the-karlsruhe-metabolomics-and-nutrition-karmen-study
#11
Manuela J Rist, Alexander Roth, Lara Frommherz, Christoph H Weinert, Ralf Krüger, Benedikt Merz, Diana Bunzel, Carina Mack, Björn Egert, Achim Bub, Benjamin Görling, Pavleta Tzvetkova, Burkhard Luy, Ingrid Hoffmann, Sabine E Kulling, Bernhard Watzl
Physiological and functional parameters, such as body composition, or physical fitness are known to differ between men and women and to change with age. The goal of this study was to investigate how sex and age-related physiological conditions are reflected in the metabolome of healthy humans and whether sex and age can be predicted based on the plasma and urine metabolite profiles. In the cross-sectional KarMeN (Karlsruhe Metabolomics and Nutrition) study 301 healthy men and women aged 18-80 years were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28813522/surveillance-in-easy-to-access-population-subgroups-as-a-tool-for-evaluating-malaria-control-progress-a-systematic-review
#12
Sanie S S Sesay, Emanuele Giorgi, Peter J Diggle, David Schellenberg, David G Lalloo, Dianne J Terlouw
BACKGROUND: The need for surveillance systems generating targeted, data-driven, responsive control efforts to accelerate and sustain malaria transmission reduction has been emphasized by programme managers, policy makers and scientists. Surveillance using easy-to-access population subgroups (EAGs) may result in considerable cost saving compared to household surveys as the identification and selection of individuals to be surveyed is simplified, fewer personnel are needed, and logistics are simpler...
2017: PloS One
https://www.readbyqxmd.com/read/28813182/impact-of-selection-bias-on-treatment-effect-size-estimates-in-randomized-trials-of-oral-health-interventions-a-meta-epidemiological-study
#13
H Saltaji, S Armijo-Olivo, G G Cummings, M Amin, B R da Costa, C Flores-Mir
Emerging evidence suggests that design flaws of randomized controlled trials can result in over- or underestimation of the treatment effect size (ES). The objective of this study was to examine associations between treatment ES estimates and adequacy of sequence generation, allocation concealment, and baseline comparability among a sample of oral health randomized controlled trials. For our analysis, we selected all meta-analyses that included a minimum of 5 oral health randomized controlled trials and used continuous outcomes...
August 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28813073/functional-health-literacy-and-quality-of-life-of-high-school-adolescents-in-state-schools-in-belo-horizonte
#14
Poliana Cristina Rocha, Dálian Cristina Rocha, Stela Maris Aguiar Lemos
Purpose: To investigate the association between functional health literacy and sociodemographic factors, quality of life, self-perception of health, and perception of contexts of violence in adolescents in state schools in Belo Horizonte. Methods: This is a cross-sectional analytical observational study with a probabilistic sample of 384 adolescents between 15 and 19 years old. Data collection was carried out in schools and included self-reporting questionnaires to assess the functional health literacy, socioeconomic classification, self-perceived health, and quality of life...
August 10, 2017: CoDAS
https://www.readbyqxmd.com/read/28812825/evaluating-global-health-partnerships-a-case-study-of-a-gavi-hpv-vaccine-application-process-in-uganda
#15
Carol Kamya, Jessica Shearer, Gilbert Asiimwe, Emily Carnahan, Nicole Salisbury, Peter Waiswa, Jennifer Brinkerhoff, Dai Hozumi
BACKGROUND: Global health partnerships have grown rapidly in number and scope, yet there has been less emphasis on their evaluation. Gavi, the Vaccine Alliance, is one such public-private partnership; in Gavi-eligible countries partnerships are dynamic networks of immunization actors who work together to support all stages and aspects of Gavi support. This paper describes a conceptual framework - the partnership framework - and analytic approach for evaluating the perceptions of partnerships' added value as well as the results from an application to one case in Uganda...
October 26, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812537/leveraging-network-analytics-to-infer-patient-syndrome-and-identify-causal-genes-in-rare-disease-cases
#16
Andreas Krämer, Sohela Shah, Robert Anthony Rebres, Susan Tang, Daniel Rene Richards
BACKGROUND: Next-generation sequencing is widely used to identify disease-causing variants in patients with rare genetic disorders. Identifying those variants from whole-genome or exome data can be both scientifically challenging and time consuming. A significant amount of time is spent on variant annotation, and interpretation. Fully or partly automated solutions are therefore needed to streamline and scale this process. RESULTS: We describe Phenotype Driven Ranking (PDR), an algorithm integrated into Ingenuity Variant Analysis, that uses observed patient phenotypes to prioritize diseases and genes in order to expedite causal-variant discovery...
August 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28812373/evaluation-of-factors-in-development-of-vis-nir-spectroscopy-models-for-discriminating-pse-dfd-and-normal-broiler-breast-meat
#17
Hongzhe Jiang, Seung-Chul Yoon, Hong Zhuang, Wei Wang, Yi Yang
1. To evaluate the performance of visible and near-infrared (Vis/NIR) spectroscopic models for discriminating true pale, soft and exudative (PSE), normal and dark, firm and dry (DFD) broiler breast meat in different conditions of preprocessing methods, spectral ranges, characteristic wavelengths selection and water-holding capacity (WHC) indexes. 2. Quality attributes of 214 intact chicken fillets (pectoralis major), such as lightness (L*), pH, and WHC indicators including drip loss (DL), water gain (WG), and expressible fluid (EF) were measured...
August 16, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28811199/comparison-of-analytical-methods-of-brain-18-f-fdg-pet-after-severe-traumatic-brain-injury
#18
Karine Madsen, Sara Hesby, Ingrid Poulsen, Stefan Fuglsang, Jesper Graff, Karen B Larsen, Lars P Kammersgaard, Ian Law, Hartwig R Siebner
BACKGROUND: Loss of consciousness has been shown to reduce cerebral metabolic rates of glucose (CMRglc) measured by brain [(18)F]FDG-PET. Measurements of regional metabolic patterns by normalization to global cerebral metabolism or cerebellum may underestimate widespread reductions. NEW METHOD: The aim of this study was to compare quantification methods of whole brain glucose metabolism, including whole brain [18F]FDG uptake normalized to uptake in cerebellum, normalized to injected activity, normalized to plasma tracer concentration, and two methods for estimating CMRglc...
August 12, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28811159/implementing-and-scaling-up-hcv-treatment-services-for-people-who-inject-drugs-and-other-high-risk-groups-in-ukraine-an-evaluation-of-programmatic-and-treatment-outcomes
#19
Alyona Mazhnaya, Anna Meteliuk, Tetiana Barnard, Alexei Zelenev, Sergii Filippovych, Frederick L Alticec
BACKGROUND: HCV prevalence estimates among people who inject drugs (PWID) in Ukraine is high (60-90%), yet barriers to HCV treatment and care remain substantial including limited access to direct acting antiviral (DAA) medications. A feasibility scale-up project implemented HCV treatment in community-based settings to improve access to DAA treatment for key populations in this context. METHODS: Using program-level data and verified medical records, we describe the development, implementation processes and outcomes for HCV treatment for PWID and other risks groups...
August 12, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28811033/strong-magnetoelectrolysis-effect-during-electrochemical-reaction-monitored-in-situ-by-high-resolution-nmr-spectroscopy
#20
Bruna Ferreira Gomes, Pollyana Ferreira da Silva, Carlos Manuel Silva Lobo, Maiara da Silva Santos, Luiz Alberto Colnago
The strong effect of magnetic field on the electrochemical (EC) reduction of a diamagnetic species was monitored in situ in a 600 MHz (14 T) NMR spectrometer. Throughout EC-NMR experiments, the diamagnetic species is influenced by the Lorentz force (cross product of current density and magnetic field), which in turn acts on analyte transport and, as a result, enhances reaction rates. This phenomenon, known as magnetoelectrolysis, has not been considered in several in situ EC-NMR studies in solution, electron paramagnetic resonance (EC-EPR) spectroscopy, and magnetic resonance imaging (EC-MRI) involving the oxidation and reduction of organic compounds and lithium ion batteries...
August 29, 2017: Analytica Chimica Acta
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