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https://www.readbyqxmd.com/read/28227463/hemodynamic-effects-of-synchronizing-an-intra-aortic-vad-in-reverse-rotation-control-with-left-ventricle-a-mock-loop-study
#1
Yaxin Wang, P Alex Smith, Daniel L Timms, Po-Lin Hsu, Richard A McMahon, Yaxin Wang, P Alex Smith, Daniel L Timms, Po-Lin Hsu, Richard A McMahon, Richard A McMahon, Daniel L Timms, Po-Lin Hsu, Yaxin Wang, P Alex Smith
The IntraVAD is an intra-aortic left ventricular assist device (LVAD) to be located in the ascending aorta. In order to enhance unloading and promote coronary flow for the left ventricle (LV), an operating mechanism, reverse-rotation control (RRc) mode, has been developed for the IntraVAD and tested in vitro in a mock circulation loop (MCL). The RRc mode consists of forward rotation (FR) and reverse rotation (RR). The synchronization between the IntraVAD and the LV was studied to offload the ventricle more effectively and to improve myocardial perfusion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218527/bioactive-peptides-isolated-from-casein-phosphopeptides-enhance-calcium-and-magnesium-uptake-in-caco-2-cell-monolayers
#2
Yong Cao, Jian-Yin Miao, Guo Liu, Zhen Luo, Zumeng Xia, Fei Liu, Mingfei Yao, Xiaoqiong Cao, Shengwei Sun, Yanyin Lin, Yaqi Lan, Hang Xiao
The ability of casein phosphopeptides (CPPs) to bind and transport minerals has been previously studied. However, the single bioactive peptides responsible for the effects of CPPs have not been identified. This study was to purify calcium-binding peptides from CPPs and to determine their effects on calcium and magnesium uptake by Caco-2 cell monolayers. Five monomer peptides designated P1 to P5 were isolated and the amino acid sequences were determined using LC-MS/MS. Compared with the CPP-free control, all five monomeric peptides exhibited significant enhancing effects on the uptake of calcium and magnesium (P < 0...
February 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28215427/method-of-hypertonic-saline-administration-effects-on-osmolality-in-traumatic-brain-injury-patients
#3
Kelly L Maguigan, Bradley M Dennis, Susan E Hamblin, Oscar D Guillamondegui
Hypertonic saline (HTS) is an effective therapy for reducing intracranial pressure (ICP). The ideal method of administration is unknown. The purpose of this study was to evaluate the method of HTS infusion and time to goal osmolality. A retrospective cohort analysis was conducted in severe TBI patients with ICP monitoring in place who received 2 doses of HTS. Patients were divided into bolus versus continuous infusion HTS cohorts. The primary outcome was median time to goal osmolality. Secondary outcomes included percentage of patients reaching goal osmolality, percent time at goal osmolality, mean cerebral perfusion pressure (CPP) and ICP, ICU length of stay, and mortality...
February 15, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28212009/2-2-bipyridyl-embedded-cycloparaphenylenes-as-a-general-strategy-to-investigate-nanohoop-based-coordination-complexes
#4
Jeff Van Raden, Shayan Louie, Lev N Zakharov, Ramesh Jasti
Owing to their unique cyclic architectures, tunable electronic properties, and supramolecular chemistries, cycloparaphenylenes (CPPs) have the potential to act as a new class of ligands for coordination cages, metal-organic frameworks (MOFs), as well as small-molecule transition-metal complexes. However, currently there is no general strategy to coordinate the cyclic framework to a variety of metal centers. We report here a general and scalable synthetic strategy to embed 2,2'-bipyridine units into the backbone of CPPs...
February 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28209404/cell-penetrating-peptides-from-basic-research-to-clinics
#5
REVIEW
Giulia Guidotti, Liliana Brambilla, Daniela Rossi
The presence of cell and tissue barriers together with the low biomembrane permeability of various therapeutics often hampers systemic drug distribution; thus, most of the available molecules are of limited therapeutic value. Opportunities to increase medicament concentrations in areas that are difficult to access now exist with the advent of cell-penetrating peptides (CPPs), which can transport into the cell a wide variety of biologically active conjugates (cargoes). Numerous preclinical evaluations with CPP-derived therapeutics have provided promising results in various disease models that, in some cases, prompted clinical trials...
February 13, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28209057/saturated-fatty-acid-analogues-of-cell-penetrating-peptide-pepfect14-role-of-fatty-acid-modification-in-complexation-and-delivery-of-splice-correcting-oligonucleotides
#6
Tõnis Lehto, Luis Vasconcelos, Helerin Margus, Ricardo Figueroa, Margus Pooga, Mattias Hällbrink, Ulo Langel
Modifying cell-penetrating peptides (CPPs) with fatty acids has long been used to improve peptide-mediated nucleic acid delivery. In this study we have revisited this phenomenon with a systematic approach where we developed a structure-activity relationship to describe the role of the acyl chain length in the transfection process. For that we took a well-studied CPP, PepFect14, as the basis and varied its N-terminal acyl chain length from 2 to 22 carbons. To evaluate the delivery efficiency, the peptides were non-covalently complexed with a splice-correcting oligonucleotide (SCO) and tested in the HeLa pLuc705 reporter cell line...
February 17, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28208995/a-comparative-analysis-of-caries-inhibitory-effect-of-remineralizing-agents-on-human-enamel-treated-with-er-yag-laser-an-in-vitro-atomic-emission-spectrometry-analysis
#7
Aswin Saseendran Nair, R Krishna Kumar, Sunil Thomas Philip, Syed Shaheed Ahameed, Sairaj Punnathara, Joby Peter
INTRODUCTION: The tug of war to maintain tooth integrity is dependent on a ratio between demineralization and remineralization. Hence, demineralization should be retarded and remineralization should be enhanced to maintain a natural equilibrium in the oral cavity. AIM: To compare in-vitro acid resistance of human enamel when using Casein Phosphopeptides Amorphous Calcium Phosphate (CPP-ACP) [GC Tooth mousse] cream, Casein Phosphopeptide Amorphous Calcium Fluoride Phosphate (CPP-ACFP) [GC Tooth mousse plus] cream, Er:YAG laser alone, combination of CPP-ACP with Er:YAG laser, CPP-ACFP with Er:YAG laser...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28197825/peculiarities-in-thermal-evolution-of-precipitated-amorphous-calcium-phosphates-with-an-initial-ca-p-ratio-of-1-1
#8
Zoltan Zyman, Matthias Epple, Anton Goncharenko, Dmytro Rokhmistrov, Oleg Prymak, Kateryna Loza
Thermal evolution of amorphous calcium phosphate (ACP) powder from a fast nitrate synthesis with a Ca/P ratio of 1:1 were studied in the range of 20-980 °C. The powder consisted of amorphous dicalcium phosphate anhydrate (CaHPO4) after heating to 200 °C. CaHPO4 gradually condensed to amorphous calcium pyrophosphate Ca2P2O7 (CPP) between 200 to 620 °C. Amorphous CPP crystallized at 620-740 °C to a metastable polymorph α'-CPP of the high-temperature phase α-CPP and β-CPP. The α'-CPP/ β-CPP phase ratio reached a maximum at 800 °C (60 wt% α'-CPP/40 wt% β-CPP), and α'-CPP gradually transformed to β-CPP at a higher temperature...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28194980/cell-penetrating-peptide-spirolactam-derivative-as-a-reversible-fluorescent-ph-probe-for-live-cell-imaging
#9
Meng-Chan Xia, Lesi Cai, Sichun Zhang, Xinrong Zhang
A colorless and nonfluorescent spirolactam derivative, RhB-R12K, was synthesized by amide condensation between the carboxyl group of rhodamine B (RhB) and the amino group of cell-penetrating peptide (CPP). The fluorescence intensity of RhB-R12K sharply increased as the pH value decreased from 8.0 to 4.9, demonstrating sensitive and reversible response to intracellular pH distribution. This CPP probe was completely water soluble, had low cytotoxicity, was membrane permeable, and was suitable for pH measurement in various organelles by choosing organelle-specific CPP sequences...
January 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28192193/differential-expression-of-endocannabinoid-system-related-genes-in-the-dorsal-hippocampus-following-expression-and-reinstatement-of-morphine-conditioned-place-preference-in-mice
#10
Wei Li, Cong-Li Zhang, Zheng-Guo Qiu
The endocannabinoid signaling plays a critical role in mediating rewarding effects to morphine. The relative stability for the expression and reinstatement of morphine conditioned place preference (CPP) suggests the involvement of differential neuroadaptations in learned associations between environmental cues and morphine. Changes in gene expression in hippocampus through the endogenous cannabinoid system (eCB) may accompany and mediate the development of such neuroadaptations to repeated morphine stimulation...
February 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28190655/development-of-helix-stabilized-cell-penetrating-peptides-containing-cationic-%C3%AE-%C3%AE-disubstituted-amino-acids-as-helical-promoters
#11
Hiroko Yamashita, Takashi Misawa, Makoto Oba, Masakazu Tanaka, Mikihiko Naito, Masaaki Kurihara, Yosuke Demizu
Cell-penetrating peptides (CPP) have attracted many scientists' attention as intracellular delivery tools due to their high cargo molecule transportation efficiency and low cytotoxicity. Therefore, in many research fields CPP, such as HIV-Tat and oligoarginine (Rn), are used to deliver hydrophilic drugs and biomolecules, including proteins, DNA, and RNA. We designed four types of CPP that contained cationic α,α-disubstituted amino acids (Api(C2Gu) and Api(C4Gu)) as helical promoters; i.e., 1-4 [FAM-β-Ala-(l-Arg-l-Arg-Xaa)3-(Gly)3-NH2 (1: Xaa=Api(C2Gu), 2: Xaa=Api(C4Gu)), 3: FAM-β-Ala-(l-Arg)8-Api(C2Gu)-(Gly)3-NH2, and 4: FAM-β-Ala-(l-Arg)5-Api(C2Gu)-(l-Arg)2-Api(C2Gu)-(Gly)3-NH2], and investigated their preferred secondary structures and cell membrane-penetrating ability...
February 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28185965/cav1-2-but-not-cav1-3-l-type-calcium-channel-subtype-mediates-nicotine-induced-conditioned-place-preference-in-miceo
#12
Yudan Liu, Meghan Harding, Jules Dore, Xihua Chen
Nicotine use is one of the most common forms of drug addiction. Although L-type calcium channels (LTCCs) are involved in nicotine addiction, the contribution of the two primary LTCC subtypes (Cav1.2 and 1.3) is unknown. This study aims to determine the contribution of these two LTCC subtypes to nicotine-induced conditioned place preference (CPP) responses by using transgenic mouse models that do not express Cav1.3 (Cav1.3(-/-)) or contain a mutation in the dihydropyridine (DHP) site of the Cav1.2 (Cav1.2DHP(-/-))...
February 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28173643/the-abuse-potential-of-%C3%AE-piperidinopropiophenone-pipp-and-%C3%AE-piperidinopentiothiophenone-pivt-two-new-synthetic-cathinones-with-piperidine-ring-substituent
#13
Chrislean Jun Botanas, Seong Shoon Yoon, June Bryan de la Peña, Irene Joy Dela Peña, Mikyung Kim, Taeseon Woo, Joung-Wook Seo, Choon-Gon Jang, Kyung-Tae Park, Young Hun Lee, Yong Sup Lee, Hee Jin Kim, Jae Hoon Cheong
A diversity of synthetic cathinones has flooded the recreational drug marketplace worldwide. This variety is often a response to legal control actions for one specific compound (e.g. methcathinone) which has resulted in the emergence of closely related replacement. Based on recent trends, the nitrogen atom is one of the sites in the cathinone molecule being explored by designer type modifications. In this study, we designed and synthesized two new synthetic cathinones, (1) α-piperidinopropiophenone (PIPP) and (2) α-piperidinopentiothiophenone (PIVT), which have piperidine ring substituent on their nitrogen atom...
February 6, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28171804/hemodynamic-and-neuro-monitoring-for-neurocritically-ill-patients-an-international-survey-of-intensivists
#14
Sanjeev Sivakumar, Fabio S Taccone, Mohammed Rehman, Holly Hinson, Neeraj Naval, Christos Lazaridis
PURPOSE: To investigate multimodality systemic and neuro-monitoring practices in acute brain injury (ABI) and to analyze differences among "neurointensivists" (NI; clinical practice comprised >1/3 by neurocritical care), and other intensivists (OI). METHODS: Anonymous 22-question Web-based survey among physician members of SCCM and ESICM. RESULTS: Six hundred fifty-five responded (66% completion rate); 422 (65%) were OI, and 226 (35%) were NI...
January 21, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28170057/animal-models-of-drug-addiction
#15
María Pilar García Pardo, Concepción Roger Sánchez, José Enrique De la Rubia Ortí, María Asunción Aguilar Calpe
The development of animal models of drug reward and addiction is an essential factor for progress in understanding the biological basis of this disorder and for the identification of new therapeutic targets. Depending on the component of reward to be studied, one type of animal model or another may be used. There are models of reinforcement based on the primary hedonic effect produced by the consumption of the addictive substance, such as the self-administration (SA) and intracranial self-stimulation (ICSS) paradigms, and there are models based on the component of reward related to associative learning and cognitive ability to make predictions about obtaining reward in the future, such as the conditioned place preference (CPP) paradigm...
January 12, 2017: Adicciones
https://www.readbyqxmd.com/read/28167334/in-vitro-enamel-erosion-and-abrasion-inhibiting-effect-of-different-fluoride-varnishes
#16
Adílis Kalina Alexandria, Thiago Isidro Vieira, Matheus Melo Pithon, Tatiana Kelly da Silva Fidalgo, Andréa Fonseca-Gonçalves, Ana Maria Gondim Valença, Lúcio Mendes Cabral, Lucianne Cople Maia
OBJECTIVE: To investigate the erosion and abrasion inhibiting effect of CPP-ACP/NaF and xylitol/NaF varnishes. METHODS: Bovine enamel samples (n=40) were exposed to the following treatments (n=10): NaF varnish (Duraphat(®), positive control); CPP-ACP/NaF varnish (MI varnishTM); xylitol/NaF (Profluorid(®)) or distilled and deionized water (MilliQ(®), negative control). The samples were submitted for 3days to 4 cycles/day of erosion (5min in Sprite Zero) and 2 cycles of abrasion/day after the first and last erosive challenge, with a toothbrush machine and slurries of a placebo toothpaste for 15s (50 strokes/s)...
January 27, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28167139/evaluation-treatment-and-follow-up-results-of-ovarian-cysts-in-childhood-and-adolescence-a-multicenter-retrospective-study-of-100-patients
#17
Banu Kucukemre Aydin, Nurcin Saka, Firdevs Bas, Yasin Yilmaz, Belma Haliloglu, Tulay Guran, Serap Turan, Abdullah Bereket, Gul Yesiltepe Mutlu, Filiz Cizmecioglu, Sukru Hatun, Digdem Bezen, Filiz Tutunculer, Nurcan Cebeci, Pinar Isguven, Nihal Memioglu, Oya Ercan, Sukran Poyrazoglu, Rüveyde Bundak, Feyza Darendeliler
STUDY OBJECTIVE: To investigate the characteristics of children with ovarian cysts at presentation and during follow up, and evaluate treatment strategies. DESIGN: Retrospective Study SETTING: Eight Pediatric Endocrinology Clinics, Turkey PARTICIPANTS: A total of 100 children and adolescents with ovarian cysts. INTERVENTIONS: Patient data collected via retrospective chart review. Patients were stratified by age into 4 groups (newborns, 1-12 months, 1-8 years, and 8-18 years)...
February 3, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28166816/the-achru-cpp-versus-usual-care-for-older-adults-with-type-2-diabetes-and-multiple-chronic-conditions-and-their-family-caregivers-study-protocol-for-a-randomized-controlled-trial
#18
Maureen Markle-Reid, Jenny Ploeg, Kimberly D Fraser, Kathryn Ann Fisher, Noori Akhtar-Danesh, Amy Bartholomew, Amiram Gafni, Andrea Gruneir, Sandra P Hirst, Sharon Kaasalainen, Caralyn Kelly Stradiotto, John Miklavcic, Carlos Rojas-Fernandez, Cheryl A Sadowski, Lehana Thabane, Jean A C Triscott, Ross Upshur
BACKGROUND: Many community-based self-management programs have been developed for older adults with type-2 diabetes mellitus (T2DM), bolstered by evidence from randomized controlled trials (RCTs) that T2DM can be prevented and managed through lifestyle modifications. However, the evidence for their effectiveness is contradictory and weakened by reliance on single-group designs and/or small samples. Additionally, older adults with multiple chronic conditions (MCC) are often excluded because of recruiting and retention challenges...
February 6, 2017: Trials
https://www.readbyqxmd.com/read/28166411/effects-of-mechanical-properties-of-lipid-bilayers-on-the-entry-of-cell-penetrating-peptides-into-single-vesicles
#19
Md Zahidul Islam, Sabrina Sharmin, Victor Levadnyy, Sayed Ul Alam Shibly, Masahito Yamazaki
The translocation of cell-penetrating peptides (CPPs) through plasma membranes of living cells is an important physiological phenomenon in biomembranes. To reveal the mechanism underlying the translocation of a CPP, transportan 10 (TP10), through lipid bilayers, we examined the effects of the mechanical properties of lipid bilayers on the entry of carboxyfluorescein (CF)-labeled TP10 (CF-TP10) into a giant unilamellar vesicle (GUV) using the single GUV method. First, we examined the effect of lateral tension in membranes on the entry of CF-TP10 into single GUVs comprising a mixture of dioleoylphosphatidylglycerol (DOPG) and dioleoylphosphatidylcholine (DOPC) (2/8)...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28164078/an-11-month-old-girl-with-central-precocious-puberty-caused-by-hypothalamic-hamartoma
#20
Da Young Yoon, Jae Hyun Kim
Central precocious puberty (CPP) is caused by premature activation of the hypothalamic-gonadal axis, and must be treated adequately. In particular, CPP that occurs at a relatively young age or in boys is likely to be caused by an organic lesion. Hypothalamic hamartoma (HH) is the most common organic cause of CPP. The present case report describes an 11-month-old female infant who presented with vaginal bleeding and rapidly progressive secondary sex characteristics from the age of 6 months. She was diagnosed with CPP following the detection of HH via magnetic resonance imaging...
December 2016: Annals of Pediatric Endocrinology & Metabolism
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