keyword
MENU ▼
Read by QxMD icon Read
search

CPP

keyword
https://www.readbyqxmd.com/read/29231727/an-anthracene-incorporated-8-cycloparaphenylene-derivative-as-emitter-in-photon-upconversion
#1
Paolo Della Sala, Amedeo Capobianco, Tonino Caruso, Carmen Talotta, Margherita De Rosa, Placido Neri, Andrea Peluso, Carmine Gaeta
The anthracene-incorporated [8]cycloparaphenylene 2 has been synthesized and its optoelectronic properties studied by UV-vis spectroscopy, cyclic voltammetry, and DFT calculations. NMR and computational studies indicate that the new cycloparaphenylene derivative possesses Cs point group symmetry. The new CPP 2 exhibits peculiar optoelectronic properties: i) fluorescence emission is blue shifted with respect to [8]cycloparaphenylene 1 and its quantum yield is higher; ii) in the presence of the octaethylporphyrin Pd complex as sensitizer, it undergoes visible light upconversion, the first case in which a cycloparaphenylene derivative is involved as emitter in low power light frequency conversion...
December 12, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29231159/facet-joint-injections-for-non-specific-low-back-pain-a-feasibility-rct
#2
Saowarat Snidvongs, Rod S Taylor, Alia Ahmad, Simon Thomson, Manohar Sharma, Angela Farr, Deborah Fitzsimmons, Stephanie Poulton, Vivek Mehta, Richard Langford
BACKGROUND: Pain of lumbar facet-joint origin is a common cause of low back pain in adults and may lead to chronic pain and disability, with associated health and socioeconomic implications. The socioeconomic burden includes an inability to return to work resulting in loss of productivity in addition to direct and indirect health-care utilisation costs. Lumbar facet-joints are paired synovial joints between the superior and inferior articular processes of consecutive lumbar vertebrae and between the fifth lumbar vertebra and the sacrum...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29225469/pelvic-vein-incompetence-clinical-perspectives
#3
REVIEW
David M Riding, Vivak Hansrani, Charles McCollum
Chronic pelvic pain (CPP) affects 24% of premenopausal women, accounts for 20%-30% of UK gynecology outpatient appointments, and has an annual pan-European economic cost of €3.8 billion. Despite extensive investigation, often including laparoscopy, up to 55% of women do not receive a diagnosis and endure persistent symptoms. In these patients, clinical management focuses on symptom control rather than treatment. It is possible that pelvic vein incompetence (PVI) is a cause of CPP, although the quality of studies investigating an association is generally low...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29225313/ingestion-of-coffee-polyphenols-improves-a-scaly-skin-surface-and-the-recovery-rate-of-skin-temperature-after-cold-stress-a-randomized-controlled-trial
#4
Sachie Ueda, Masanori Tanahashi, Yuko Higaki, Kayoko Iwata, Yoshinori Sugiyama
Coffee polyphenols (CPPs) derived from coffee beans have beneficial effects on blood pressure and vascular endothelial function. In addition, CPPs suppress ultraviolet light induced erythema. However, the effects of CPPs on dry skin and cutaneous vascular function have not been clarified. We investigated the effects of CPPs on dry skin and the recovery rate (RR) of skin temperature after a cold-stress test as a measure of vascular function in subjects with visible scaliness in a double-blind, placebo-controlled, randomized study...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29224360/predicting-intelligibility-deficit-in-dysphonic-speech-with-cepstral-peak-prominence
#5
Keiko Ishikawa, Alessandro de Alarcon, Sid Khosla, Lisa Kelchner, Noah Silbert, Suzanne Boyce
OBJECTIVES: The aim of this study was to examine the potential of cepstral peak prominence (CPP) for predicting the intelligibility deficit in dysphonic speech. METHODS: Sentences from Hearing-in-Noise Test were recorded from 18 speakers with dysphonia and 18 speakers with normal voice. These samples were presented to 60 adults with normal hearing in quiet and noise at signal to noise ratio of +0 dB. Intelligibility was measured by orthographic transcription. Cepstral peak prominence was measured for all samples...
December 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29223764/hypoxia-induced-and-hif1%C3%AE-vegf-mediated-tight-junction-dysfunction-in-choriocarcinoma-cells-implications-for-preeclampsia
#6
Yuan Zhang, Hai-Jun Zhao, Xin-Ru Xia, Fei-Yang Diao, Xiang Ma, Jing Wang, Li Gao, Jie Liu, Chao Gao, Yu-Gui Cui, Jia-Yin Liu
INTRODUCTION: Accumulated data indicate that placental hypoxia is implicated in the pathogenesis of preeclampsia (PE). Tight junction (TJ) is important structure that sustains normal placental barrier function, its dysregulation under hypoxia has been observed. This study was designed to explore hypoxia-induced TJ dysfunction in trophoblast cells and its possible involvement in PE pathophysiology. METHODS: Choriocarcinoma cells were grown in a monolayer and treated with cobalt chloride (CoCl2) to induce hypoxia...
December 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29222049/mtd-like-motif-of-a-bh3-only-protein-bnip1-induces-necrosis-accompanied-by-intracellular-calcium-spike
#7
Junghee Park, Ji-Hye Han, Seung-Hyun Myung, Young-Woo Seo, Tae-Hyoung Kim
The mitochondrial targeting domain (MTD) of Noxa has necrosis-inducing activity when conjugated with cell-penetrating peptide (CPP). In this study, we report another MTD-like motif, B1MLM, found in BNIP1, a pro-apoptotic BH3-only protein found in the endoplasmic reticulum membrane. The B1MLM peptide, conjugated with CPP, induced necrosis in a way similar to that of R8:MTD. R8:B1MLM caused an intracellular calcium spike, mitochondrial reactive oxygen species generation, and mitochondrial fragmentation. The cytosolic calcium spike was likely due to the opening of the mitochondrial permeability transition pore...
December 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29218940/-studying-on-purification-technology-of-resina-draconis-phenol-extracts-based-on-design-space-method
#8
Jian Zhang, Xin Zhang, Yu-An Bi, Gui-Hong Xu, Wen-Zhe Huang, Zhen-Zhong Wang, Wei Xiao
The "design space" method was used to optimize the purification process of Resina Draconis phenol extracts by using the concept of "quality derived from design" (QbD). The content and transfer rate of laurin B and 7,4'-dihydroxyflavone and yield of extract were selected as the critical quality attributes (CQA). Plackett-Burman design showed that the critical process parameters (CPP) were concentration of alkali, the amount of alkali and the temperature of alkali dissolution. Then the Box-Behnken design was used to establish the mathematical model between CQA and CPP...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29216351/1-adrenoceptor-in-the-central-amygdala-is-required-for-unconditioned-stimulus-induced-drug-memory-reconsolidation
#9
Huiwen Zhu, Yiming Zhou, Zhiyuan Liu, Xi Chen, Yanqing Li, Xing Liu, Lan Ma
Background: Drug memories become labile and reconsolidated after retrieval by presentation of environmental cues (conditioned stimulus, CS) or drugs (unconditioned stimulus, US). Whether CS- and US-retrieval trigger different memory reconsolidation processes is not clear. Methods: Protein synthesis inhibitor or β-AR antagonist was systemically administrated or intra-central amygdala (CeA) infused immediately after cocaine re-exposure in cocaine-conditioned place preference (CPP) or self-administration (SA) mice models...
December 5, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29215139/a-novel-and-selective-nociceptin-receptor-nop-agonist-1-1-cis-4-isopropylcyclohexyl-piperidin-4-yl-1h-indol-2-yl-methanol-at-312-decreases-acquisition-of-ethanol-induced-conditioned-place-preference-in-mice
#10
Nurulain T Zaveri, Paul V Marquez, Michael E Meyer, Willma E Polgar, Abdul Hamid, Kabirullah Lutfy
BACKGROUND: Nociceptin/Orphanin FQ (N/OFQ), the endogenous peptide agonist for the opioid receptor-like (ORL1) receptor (also known as NOP or the nociceptin receptor), has been shown to block the acquisition and expression of ethanol-induced conditioned place preference (CPP). Here, we report the characterization of a novel small-molecule NOP ligand AT-312 (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol) in receptor binding and GTPγS functional assays in vitro...
December 7, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29215025/co-expression-of-mfat-1-and-pig-igf-1-genes-by-recombinant-plasmids-in-modified-chitosan-nanoparticles-and-its-synergistic-effect-on-mouse-immunity
#11
Qi Xiong, Jianlin Chen, Fei-Lin Li, Shiji Zhao, Xiaoping Wan, Xiao Yang, Jianglin Li, Danyu Luo, Zezhou Wang, Xuebin Lv, Rong Gao
To develop a cost-effective molecular regulator to improve growth metabolism and immunity of animals, a recombinant plasmid co-expressing fatty acid desaturase (mFat-1) and pig insulin growth like factor 1 (IGF-1) genes was constructed by the 2 A self-cleavage technique. After entrapment within modified chitosan nanoparticles (chitosan modified with polyethyleneglycol-polyethylenimine, CPP), the recombinant plasmid was injected intramuscularly into mice. Compared with controls, co-expression of mFat-1 and IGF-1 significantly raised the level of serum IGF-1, and increased the liver and muscle docosa hexaenoic acid (DHA) content...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214239/protonation-enhances-the-inherent-helix-forming-propensity-of-phlip
#12
Chitrak Gupta, Blake Mertz
Cell-penetrating peptides (CPPs) can be potentially used in targeted delivery of therapeutic cargoes. However, their conformation in solution is poorly understood. We employed molecular dynamics simulations to probe the structural fluctuations of an anionic CPP, pH Low Insertion Peptide (pHLIP), in solution to determine the effects of modifications to selected residues on the structure of pHLIP. Two types of modifications were tested: (1) protonation of aspartic acid residues and (2) point mutations known to affect the acid sensitivity of pHLIP...
November 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/29213166/precocious-puberty-an-experience-from-a-major-teaching-hospital-in-central-saudi-arabia
#13
Huda A Osman, Nasir A M Al-Jurayyan, Amir M I Babiker, Hessah M N Al-Otaibi, Reem D H AlKhalifah, Sharifah D A Al Issa, Sarar Mohamed
Precocious puberty is a developmental process that gives rise to secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. In general, precocious puberty can be classified as central or peripheral. This is a retrospective hospital-based study was conducted at King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia, during the period January 1990 and December 2016. Data were abstracted from the medical records of patients diagnosed with precocious puberty, with special emphasis on age, sex, clinical characteristics, and relevant hormonal assay...
2017: Sudanese Journal of Paediatrics
https://www.readbyqxmd.com/read/29212405/a-description-of-a-new-continuous-physiologic-index-in-tbi-using-the-correlation-between-pulse-amplitude-of-icp-and-cerebral-perfusion-pressure
#14
Frederick Adam Zeiler, Joseph Donnelly, David Menon, Peter Smieleweski, Peter John Hutchinson, Marek Czosnyka
To describe a new continuous index of physiologic measurement in a TBI population, the moving correlation coefficient between intracranial pressure (ICP) pulse amplitude (AMP) and cerebral perfusion pressure (CPP), which we refer to as RAC. We use patient examples of sustained intracranial hypertension, systemic arterial hypotension and plateau waves, as well as the retrospective analysis of 358 non-decompressive craniectomy (DC) traumatic brain injury (TBI) patients with high frequency ICP and ABP data, to explore the relationships of this new index, RAC, with AMP, ICP, CPP, RAP, pressure reactivity index (PRx) and pulse amplitude index (PAx)...
December 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29212156/effects-of-cerebral-perfusion-pressure-on-regional-cerebral-blood-flow-in-dogs-with-acute-epidural-hematoma-quantitative-evaluation-with-contrast-enhanced-ultrasound
#15
Hongwei Cheng, Xiang Mao, Zonggang Hou, Jian Xu, Shuyu Hao, Huan Li, Baiyun Liu
To discuss the relationship between the regional cerebral blood flow (rCBF) and cerebral perfusion pressure (CPP) and the effect of CPP on rCBF in different spaces in an experimental animal model. As the ICP increased, the CPP and rCBF (A × β value measured by CEU) decreased to varying degrees. The rCBF1 and rCBF2 were well correlated with the CPP. At the same CPP, rCBF1 decreased significantly than the level of rCBF2 (p < 0.01). Six healthy cross-breed dogs, both males and females, weighing 18.3 ± 1...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211451/clip6-pna-peptide-conjugates-non-endosomal-delivery-of-splice-switching-oligonucleotides
#16
Terese Soudah, Maxim Mogilevsky, Rotem Karni, Eylon Yavin
Efficient delivery of oligonucleotides still remains a challenge in the field of oligonucleotide based therapy. Peptide nucleic acid (PNA), a DNA analogue that is typically synthesized by solid phase peptide chemistry, has been conjugated to a variety of cell penetrating peptides (CPP) as a means of improving its cellular uptake. These CPPs typically deliver their cargoes into cells by an endosomal-dependent mechanism resulting in lower bioavailability of the cargo. Herein, we designed and synthesized PNA-peptide conjugates as splice switching oligonucleotides (SSO) targeting the Mnk2 gene, a therapeutic target in cancer...
December 6, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29211281/effect-of-fluoride-dentifrice-and-casein-phosphopeptide-amorphous-calcium-phosphate-cream-with-and-without-fluoride-in-preventing-enamel-demineralization-in-a-ph-cyclic-study
#17
Priscila de Pinto Sinfiteli, Thereza Christina Lopes Coutinho, Patrícia Regina Almeida de Oliveira, Wesley Felisberto Vasques, Leandra Matos Azevedo, André Maues Brabo Pereira, Monica Almeida Tostes
OBJECTIVE: Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) complexes are anticariogenic and capable of remineralizing the early stages of enamel lesions. The use of fluoride prevents dental decay and the association of CPP-ACP with fluoride can increase remineralization. To evaluate the effect of CPP-ACP and CPP-ACPF creams associated with a fluoride dentifrice to prevent enamel demineralization in a pH cyclic model. MATERIAL AND METHODS: Previously selected by surface microhardness (SH) analysis, human enamel blocks (n = 56) were submitted to daily treatment with dentifrice in a pH-cycling model...
November 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29211280/in-vitro-effect-of-amorphous-calcium-phosphate-paste-applied-for-extended-periods-of-time-on-enamel-remineralization
#18
Ana Elisa de Mello Vieira, Marcelle Danelon, Danielle Mendes da Camara, Eliana Rodrigues Rosselli, Stuart R Stock, Mark L Cannon, Xianghui Xiao, Francesco De Carlo, Alberto Carlos Botazzo Delbem
OBJECTIVES: Dental applications based on the unique characteristics of amorphous calcium phosphate stabilized by casein phosphopeptides (CPP-ACP) have been proposed, as well as the improvement of its properties. The objective of this study was to determine the ability of topically applied CPP-ACP from a commercial product to remineralize subsurface lesions when applied for extended periods of time (3 h and 8 h). MATERIAL AND METHODS: Artificially induced carious lesions were produced in 50 bovine enamel blocks previously selected by surface hardness...
November 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29204804/influence-of-preoptic-estradiol-on-behavioral-and-neural-response-to-cocaine-in-female-sprague-dawley-rats
#19
Christopher L Robison, Julia R Martz, Juan M Dominguez
RATIONALE: Systemic estradiol (E2) increases the behavioral and neural response to cocaine. Where in the brain E2 acts to modulate cocaine response is not entirely clear. Evidence supports a role in this modulation for several candidate regions, including the medial preoptic area (mPOA). OBJECTIVES: This study examined whether manipulation of E2 in the mPOA modulates differing behavioral responses to cocaine and whether this is reflected in differing levels of c-Fos in the NAc following cocaine administration...
December 4, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29203313/determining-the-lower-limit-of-cerebral-perfusion-pressure-in-patients-undergoing-decompressive-craniectomy-following-traumatic-brain-injury
#20
Jin Eun, Joon Huh, Seo-Yeon Yang, Han-Yong Huh, Jae-Kun Ahn, Kwang-Wook Cho, Young-Woo Kim, Sung-Lim Kim, Jong-Tae Kim, Do-Sung Yoo, Hae-Kwan Park, Cheol Ji
OBJECTIVE: In the severe traumatic brain injured (TBI) patient, maintaining the systolic blood pressure (BP) over 90 mmHg, the intracranial pressure (ICP) under 20 mmHg and the cerebral perfusion pressure (CPP) greater than 60∼70 mmHg is recommended to improve clinical outcomes. But a recommended CPP value for patients treated with decompression craniectomy (DC) is not clearly studied. The authors tried to determine whether the targeted CPP can be lowered in patients with DC. METHODS: 191 patients underwent DC for TBI included in this retrospective analysis...
December 1, 2017: World Neurosurgery
keyword
keyword
77103
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"