Ping Hao, Xiaonan Yang, Wen Yin, Xinyi Wang, Yun Ling, Mengyao Zhu, Yue Yu, Shouhai Chen, Yuan Yuan, Xiaoyu Quan, Zhiheng Xu, Jiahui Zhang, Wenjia Zhao, Ying Zhang, Chunlian Song, Qing Xu, Shuangshuang Qin, Yi Wu, Xianghua Shu, Kunhua Wei
The objective of this study was to investigate the protective effect of Crataegus pinnatifida polysaccharide (CPP) on non-alcoholic fatty liver disease (NAFLD) induced by a high-fat diet (HFD) in mice. The findings demonstrated that CPP improved free fatty acid (FFA)-induced lipid accumulation in HepG2 cells and effectively reduced liver steatosis and epididymal fat weight in NAFLD mice, as well as decreased serum levels of TG, TC, AST, ALT, and LDL-C. Furthermore, CPP exhibited inhibitory effects on the expression of fatty acid synthesis genes FASN and ACC while activating the expression of fatty acid oxidation genes CPT1A and PPARα...
2024: Frontiers in Veterinary Science