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https://www.readbyqxmd.com/read/29675846/vasoactive-intestinal-peptide-is-upregulated-in-women-with-endometriosis-and-chronic-pelvic-pain
#1
Vladimir Bourlev, Christian Moberg, Natalia Ilyasova, Eva Davey, Theodora Kunovac Kallak, Matts Olovsson
PROBLEM: Chronic pelvic pain (CPP) causes compromised the quality of life in women with endometriosis and is often attributed to local inflammation and ingrowth of nerve fibers. In this pilot study, we aimed to investigate whether the inflammation-related vasoactive intestinal peptide (VIP) and interleukin (IL)-6 were increased in affected patients. METHOD OF STUDY: Endometrial and endometriotic tissue biopsy specimens, and serum and peritoneal fluid (PF) samples, were obtained from 85 endometriosis patients and 53 controls...
April 19, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29673685/comparison-of-efficacy-of-dental-varnish-containing-fluoride-either-with-cpp-acp-or-bioglass-on-root-caries-ex-vivo-study
#2
A Sleibi, A R Tappuni, Graham R Davis, P Anderson, A Baysan
OBJECTIVES: To compare the efficacy of fluoride varnishes either casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) or bioglass particles on the severity index of root caries. METHODS: Visual-tactile assessments including lesion hardness was carried out to categorise the severity index of 80 extracted teeth with primary root caries. These teeth were randomly divided into four groups; CPP-ACP and fluoride, bioglass and fluoride, fluoride only, and no treatment...
April 16, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29671679/the-cut-off-analysis-using-visual-analogue-scale-and-cepstral-assessments-on-severity-of-voice-disorder
#3
Yeon Woo Lee, Geun Hyo Kim, In Ho Bae, Hee June Park, Soo Geun Wang, Soon Bok Kwon
PURPOSE: The aims of this study were to: (1) determine the visual analogue scale (VAS) and cepstrum peak prominence (CPP) cut-off points on the ratings of numerical scale (NS) related to the severity of voice disorder ratings and (2) verify the discriminative power of these cut-off points for distinguishing between different severities of voice disorder. METHODS: Auditory-perceptual severity assessments (VAS and four-point NS) of 214 voice samples were performed by three speech-language pathologists and CPP parameters were used for the acoustic analysis...
April 19, 2018: Logopedics, Phoniatrics, Vocology
https://www.readbyqxmd.com/read/29670331/cell-penetrating-peptide-conjugates-of-gambogic-acid-enhance-the-antitumor-effect-on-human-bladder-cancer-ej-cells-through-ros-mediated-apoptosis
#4
Lei Lyu, Lu-Qi Huang, Tao Huang, Wei Xiang, Jing-Dong Yuan, Chuan-Hua Zhang
Background: Gambogic acid (GA) is the main active ingredient of resin gamboges and possesses anti-cancer activity toward various human cancer cells. However, clinical application of GA has been limited by its poor aqueous solubility and dose-limiting toxicities. Cell-penetrating peptides (CPPs) are widely used to deliver anti-cancer drugs into cancer cells and to enhance the water solubility of drugs. Purpose: The object of this study was to synthesize peptide-drug conjugates in which the cell-penetrating peptide TAT (trans-activator of transcription) was conjugated to GA and evaluated the anti-cancer activity of this GA-CPP conjugate (GA-TAT) in EJ bladder cancer cells...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29667304/inhibition-of-alpha7-nicotinic-receptors-in-the-ventral-hippocampus-selectively-attenuates-reinstatement-of-morphine-conditioned-place-preference-and-associated-changes-in-ampa-receptor-binding
#5
Victoria L Wright, Polymnia Georgiou, Alexis Bailey, David J Heal, Christopher P Bailey, Susan Wonnacott
Recurrent relapse is a major problem in treating opiate addiction. Pavlovian conditioning plays a role in recurrent relapse whereby exposure to cues learned during drug intake can precipitate relapse to drug taking. α7 nicotinic acetylcholine receptors (nAChRs) have been implicated in attentional aspects of cognition and mechanisms of learning and memory. In this study we have investigated the role of α7 nAChRs in morphine-conditioned place preference (morphine-CPP). CPP provides a model of associative learning that is pertinent to associative aspects of drug dependence...
April 17, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29665012/wavelet-pressure-reactivity-index-a-validation-study
#6
Xiuyun Liu, Marek Czosnyka, Joseph Donnelly, Danilo Cardim, Manuel Cabeleira, Peter J Hutchinson, Xiao Hu, Peter Smielewski, Ken Brady
KEY POINTS: The brain is vulnerable to damage from too little or too much blood flow. A physiological mechanism called cerebral autoregulation (CA) exists to maintain stable blood flow even if cerebral perfusion pressure (CPP) is changing. A robust method for assessing CA is not yet available. There are still some problems with the traditional measure, the pressure reactivity index (PRx). We introduced a new method, wavelet transform method (wPRx) to assess CA using data from two sets of controlled hypotension experiments in piglets: One set with artificially manipulated ABP oscillations; the other group were spontaneous ABP waves...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29658069/nine-prophylactic-polishing-pastes-impact-on-discoloration-gloss-and-surface-properties-of-a-cad-cam-resin-composite
#7
Anja Liebermann, Sebastian Spintzyk, Marcel Reymus, Ernst Schweizer, Bogna Stawarczyk
OBJECTIVES: To investigate discoloration reduction and changes of surface properties of a CAD/CAM resin composite after 14 days´ storage in red wine and polishing with nine different prophylactic polishing pastes (PPPs). MATERIALS AND METHODS: Rectangular discs (N = 172) were fabricated and polished (P4000) using GC Cerasmart (GC Europe) to investigate different polishing protocols with 1-4 related descending PPPs (22 in total): Cleanic/CLE-Kerr, CleanJoy/CLJ-Voco, Clean Polish/Super Polish/SPO-Kerr, Clinpro Prophy Paste/CPP-3M, Détartrine/DET-Septodont, Nupro/NUP-Dentsply Sirona, Prophy Paste CCS/CCS-Directa, Proxyt/PXT-Ivoclar Vivadent, and Zircate/ZIR Prophy Paste-Dentsply Sirona...
April 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29657876/magnesium-disorders-can-cause-calcium-pyrophosphate-deposition-disease-a-case-report-and-literature-review
#8
REVIEW
Akanksha Joshi, Chokkalingam Siva
Calcium pyrophosphate deposition (CPPD) disease, also known as pseudogout, is one of the most common forms of inflammatory arthritis. A variety of comorbidities and metabolic conditions have been recognized to predispose to CPPD. We describe here a patient with chronic CPP arthritis due to hypomagnesemia, which is one of the metabolic etiologies associated with CPPD, especially in younger patients. We also performed a literature search and reviewed all reported cases of CPPD disease associated with hypomagnesemia...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29656676/cell-penetrating-peptides-a-comparative-transport-analysis-for-474-sequence-motifs
#9
Katrin Ramaker, Maik Henkel, Thorsten Krause, Niels Röckendorf, Andreas Frey
Delivering reagents into cells is a key demand in molecular medicine. The vehicle of choice is often cell penetrating peptides (CPPs), which can ferry conjugated cargo across membranes. Although numerous peptides have been shown to promote such uptake events, there has been no comprehensive comparison of individual performance under standardized conditions. We have devised a method to rapidly analyze the ability of a multitude of CPP conjugates to carry a model cargo into HeLa cells. Sequence information for 474 CPPs was collected from literature sources, and the respective peptides were synthesized and modified with carboxyfluorescein (FAM) as model cargo...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29653223/acid-sensitive-hybrid-polymeric-micelles-containing-a-reversibly-activatable-cell-penetrating-peptide-for-tumor-specific-cytoplasm-targeting
#10
Baoqiang Tang, Jennica L Zaro, Yan Shen, Qian Chen, Yinglan Yu, Pingping Sun, Yanqi Wang, Wei-Chiang Shen, Jiasheng Tu, Chunmeng Sun
Cell-penetrating peptides (CPPs) have become a novel drug delivery system due to their distinct advantages, including high cell transmembrane potency and ability to carry cargo molecules inside cells. However, owing to their cationic charge and non-specificity characteristics, the clinical application of CPPs is limited. In the current study, we engineered a reversibly activatable cell-penetrating peptide (RACPP), containing oligoarginine fused to a pH-sensitive masking sequence via a polyglycine linker ((HE)10 G5 R6 or HE-CPP) with ultra-pH-sensitivity...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29650049/variation-in-general-supportive-and-preventive-intensive-care-management-of-traumatic-brain-injury-a-survey-in-66-neurotrauma-centers-participating-in-the-collaborative-european-neurotrauma-effectiveness-research-in-traumatic-brain-injury-center-tbi-study
#11
Jilske A Huijben, Victor Volovici, Maryse C Cnossen, Iain K Haitsma, Nino Stocchetti, Andrew I R Maas, David K Menon, Ari Ercole, Giuseppe Citerio, David Nelson, Suzanne Polinder, Ewout W Steyerberg, Hester F Lingsma, Mathieu van der Jagt
BACKGROUND: General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess and quantify variation in perceptions on intensive care unit (ICU) management of patients with TBI in European neurotrauma centers. METHODS: We performed a survey as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study...
April 13, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29649000/review-and-evaluation-of-patient-centered-psychosocial-assessments-for-children-with-central-precocious-puberty-or-early-puberty
#12
REVIEW
Valerie S L Williams, Ahmed M Soliman, Amy M Barrett, Karen O Klein
The objective of this study was to assess the current use of patient-centered psychosocial assessments for the evaluation of children with central precocious puberty (CPP). Studies evaluating the psychosocial impact of CPP were identified through searches of the PubMed and Cochrane Library databases, ClinicalTrials.gov, a drug prescribing information database, and regulatory websites. Studies were screened using prespecified inclusion and exclusion criteria. Potentially relevant patient-centered outcome assessments (including patient-, parent- or observer-reported measures) used in the identified studies were evaluated in detail for their relevance in CPP...
April 12, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29644372/fullerene-size-controls-the-selective-complexation-of-11-cpp-with-pristine-and-endohedral-fullerenes
#13
I González-Veloso, E M Cabaleiro-Lago, J Rodríguez-Otero
The ability of the carbon nanoring [11]cycloparaphenylene ([11]CPP) for coordinating fullerenes has been tested using a series of hosts, including the pristine fullerenes C60, C70, C76 and C78, the clusterfullerene Sc3N@C80, monometallic endofullerenes Y@C82 and Tm@C82, and dimetallic endofullerenes Y2@C82 and Lu2@C82. A systematic theoretical study employing dispersion corrected density functional methods has been carried out in order to explore the characteristics of the complexes and the strength of the interaction...
April 12, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29628614/pelvic-congestion-syndrome-systematic-review-of-treatment-success
#14
REVIEW
Candace L Brown, Magda Rizer, Ryan Alexander, Emerson E Sharpe, Paul J Rochon
Pelvic venous insufficiency is now a well-characterized etiology of pelvic congestion syndrome (PCS). The prevalence of CPP is 15% in females aged 18 to 50 years in the United States and up to 43.4% worldwide. In addition to individual physical, emotional, and quality-of-life implications of CPP, there are profound healthcare and socioeconomic expenses with estimated annual direct and indirect costs in the United States in excess of 39 billion dollars. PCS consists of clinical symptoms with concomitant anatomic and physiologic abnormalities originating in venous insufficiency...
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29626650/rewarding-and-reinforcing-effects-of-4-chloro-2-5-dimethoxyamphetamine-and-ah-7921-in-rodents
#15
Hye Jin Cha, Seo Young Jeon, Hwa Jin Jang, Jisoon Shin, Young-Hoon Kim, Soo Kyung Suh
New psychoactive substances (NPSs), i.e., newly designed substances with chemical residues that are slightly different from those of known psychoactive substances, have been emerging since the late 2000s, and social problems related to the use of these substances are increasing globally. Two such NPSs are 4-chloro-2,5-dimethoxyamphetamine (DOC), a psychedelic substance that is structurally related to amphetamine, and AH-7921, an opioid analgesic that is used for recreational purposes and has a potency similar to that of morphine...
April 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29626506/hippocampal-glial-cells-modulate-morphine-induced-behavioral-responses
#16
Fatemehsadat Seyedaghamiri, Soomaayeh Heysieattalab, Narges Hosseinmardi, Mahyar Janahmadi, Azadeh Elahi-Mahani, Farhad Salari, Mehdi Golpayegani, Habibeh Khoshbouei
Drugs of abuse cause persistent alterations in synaptic plasticity that is thought to underlie addictive-like behaviors. Although, the perisynaptic glial cells are implicated in metabolic maintenance and support of the nervous systems, accumulating evidence suggests that glial cells exert a modulatory action on synaptic functions and participate in synaptic plasticity. However, it is well-documented that glial cells are associated with the acquisition of rewarding effects of abused drugs. The role of hippocampal glial cells in addictive-like behaviors remains poorly understood...
April 4, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29626492/environmental-enrichment-reduces-cocaine-neurotoxicity-during-cocaine-conditioned-place-preference-in-male-rats
#17
Luana Freese, Felipe Borges Almeida, Nubia Heidrich, Alana Witt Hansen, Luiza Steffens, Aline Steinmetz, Dinara Jaqueline Moura, Rosane Gomez, Helena Maria Tannhauser Barros
Environmental enrichment (EE) has a neuroprotective role and prevents the development of cocaine addiction behavior in rats. Studies showing the role of EE in cocaine toxicity are nonexistent. We hypothesized that rats exposed to EE are protected from cocaine-induced changes in the redox profile and DNA damage after undergoing conditioned place preference (CPP). Ten male Wistar rats were placed in EE cages equipped with toys, a ladder and tunnels, and ten were provided clean, standard laboratory housing (non-EE)...
April 4, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29625989/a-cell-penetrating-peptide-fused-phage-lysin-kills-intracellular-mrsa-in-keratinocytes-and-treatment-for-skin-infections-of-mice
#18
ZhaoFei Wang, LiCheng Kong, Yang Liu, Qiang Fu, ZeLin Cui, Jian Wang, JingJiao Ma, HengAn Wang, YaXian Yan, JianHe Sun
Staphylococcus aureus ( S. aureus ) is the major pathogen that causes skin and skin structure infections, which is able to survive and persist in keratinocytes of the epidermis. Since the evolution of multi-drug resistant bacteria, the use of phages and their lysins presents a promising alternative approach. In this study, a cell wall hydrolase (also called lysin) derived from Staphylococcus phage JD007, short for JDlys, was identified. The JDlys showed a strong lytic activity against MRSA strains from different sources and multilocus sequence typing (MLST) types...
April 6, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29624527/dezocine-alleviates-morphine-induced-dependence-in-rats
#19
Fei-Xiang Wu, Hasan Babazada, Hao Gao, Xi-Ping Huang, Chun-Hua Xi, Chun-Hua Chen, Jin Xi, Wei-Feng Yu, Renyu Liu
BACKGROUND: Opioid dependence is a major public health issue without optimal therapeutics. This study investigates the potential therapeutic effect of dezocine, a nonaddictive opioid, in opioid dependence in rat models. METHODS: Dezocine was administered intraperitoneally to a morphine-dependent rat model to investigate its effect on withdrawal and conditioned place preference (CPP). Effect of dezocine on morphine withdrawal syndrome and CPP was analyzed using 2-way analysis of variance (ANOVA) followed by Tukey's post hoc test...
April 5, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29621570/mne-scan-software-for-real-time-processing-of-electrophysiological-data
#20
Lorenz Esch, Limin Sun, Viktor Klüber, Seok Lew, Daniel Baumgarten, P Ellen Grant, Yoshio Okada, Jens Haueisen, Matti S Hämäläinen, Christoph Dinh
BACKGROUND: Magnetoencephalography (MEG) and Electroencephalography (EEG) are noninvasive techniques to study the electrophysiological activity of the human brain. Thus, they are well suited for real-time monitoring and analysis of neuronal activity. Real-time MEG/EEG data processing allows adjustment of the stimuli to the subject's responses for optimizing the acquired information especially by providing dynamically changing displays to enable neurofeedback. NEW METHOD: We introduce MNE Scan, an acquisition and real-time analysis software based on the multipurpose software library MNE-CPP...
April 2, 2018: Journal of Neuroscience Methods
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