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Jung Min Cho, Do Hyun Kim, Min Sook Yoo, Sungwoo Bae, Dong Soo Kim
In this study, we intend to find the laminate condition for improvement of the chemical resistance of the aluminum pouch film widely used as the coating material of the secondary battery. Here, we investigated the properties including the initial adhesive strength and electrolyte resistance between the metal film layer aluminum and the sealant layer cast polypropylene (CPP) film. As for the laminating condition, we changed the temperature and line speed and maintained the identical pressure conditions. A roll-to-roll dry laminate coating system was used in surface treatment agent coating, adhesive coating, and film laminate...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Gaowei Hu, Wenlv Zheng, Ao Li, Yaru Mu, Mingyu Shi, Tuofan Li, Haitao Zou, Hongxia Shao, Aijian Qin, Jianqiang Ye
Cell-penetrating peptide (CPP) is a promising cargo for delivering bioactive molecules. In this study, the N terminus of VP1 from chicken anemia virus, designated as CVP1, was found to carry enriched arginine residues with α-helix. By confocal imaging, flow cytometry and MTT assay, we identified CVP1 as a novel, safe and efficient CPP. CVP1-FITC peptide could entry different types of cells tested with dose dependence, but without cytotoxic effects. Compared with TAT-FITC peptide, the CVP1-FITC peptide showed much higher cell-penetrating activity...
February 13, 2018: Veterinary Research
Michal Feldman, Dan Levy
A large body of evidence accumulating in the past few years indicates the physiological significance of non-histone proteins lysine methylation, catalyzed by protein lysine methyl transferases (PKMTs). Dysregulation of these enzymes was shown to contribute to the development and progression of numerous diseases. SETD6 lysine methylatransferase was recently shown to participate in essential cellular processes, such as the NFkB pathway, oxidative stress and also the Wnt signaling cascade. In order to test the effect of blocking SETD6 catalytic activity, we used the peptide inhibition method, which is considered highly specific and can potentially target almost any protein...
January 12, 2018: Oncotarget
Pranali Deshpande, Aditi Jhaveri, Bhushan Pattni, Swati Biswas, Vladimir Torchilin
Off-target effects of drugs severely limit cancer therapy. Targeted nanocarriers are promising to enhance the delivery of therapeutics to tumors. Among many approaches for active tumor-targeting, arginine-rich cell penetrating peptides (AR-CPP) and ligands specific to target over-expressed receptors on cancer-cell surfaces, are popular. Earlier, we showed that the attachment of an AR-CPP octaarginine (R8) to the surface of DOXIL® (Doxorubicin encapsulated PEGylated liposomes) improved cytoplasmic and nuclear DOX delivery that enhanced the cytotoxic effect in vitro and improved therapeutic efficacy in vivo...
November 2018: Drug Delivery
Ketaki Dinkar Jawale, Sharad Basavraj Kamat, Jayakumar Appasaheb Patil, Girish Shankar Nanjannawar, Rutuja Vijay Chopade
Aim: The aim of this study was to determine remineralizing potential of grape seed extract (GSE) compared to casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and calcium glycerophosphate (CaGP) through pH-cycling model and subsequent evaluation using polarized light microscope (PLM). Subjects and Methods: Twenty sound human teeth fragments of ten teeth were obtained from the cervical portion of the roots and were stored in demineralizing solution for 96 h at 37°C to induce artificial root carious lesion...
November 2017: Journal of Conservative Dentistry: JCD
Casey J Allen, Ty K Subhawong, Mena M Hanna, Lydia Chelala, M Ross Bullock, Carl I Schulman, Kenneth G Proctor
Arginine vasopressin (AVP) is often used as an alternative pressor to catecholamines (CATs). However, unlike CATs, AVP is a powerful antidiuretic that could promote edema. We tested the hypothesis that AVP promoted cerebral edema and/or increased requirements for osmotherapy, relative to those who received CATs, for cerebral perfusion pressure (CPP) management after traumatic brain injury (TBI). This is a retrospective review of 286 consecutive TBI patients with intracranial pressure monitoring at a single institution from September 2008 to January 2015...
January 1, 2018: American Surgeon
Sulé Gunter, Chanel Robinson, Gavin R Norton, Angela J Woodiwiss, Linda Tsang, Aletta M E Millen, Patrick H Dessein
Apelin can improve arterial function by enhancing the expression of endothelial nitric oxide synthase but this effect depends markedly on endothelial integrity. We hypothesized that inflammation influences the potential impact of apelin on arterial function in rheumatoid arthritis (RA). We assessed the associations of apelin concentrations with arterial stiffness (pulse wave velocity), wave reflection (augmentation index, reflected wave pressure, and reflection magnitude), and pressure pulsatility (central systolic pressure (CSP), central pulse pressure (CPP), peripheral pulse pressure (PPP), pulse pressure amplification (PPamp), and forward wave pressure (Pf)) among 170 RA patients without cardiovascular disease...
February 8, 2018: Clinical Rheumatology
Emel Mashaki Ceyhan, Hakki Gürsöz, Ali Alkan, Hacer Coşkun, Oğuzhan Koyuncu, Stuart Walker
Introduction: Regulatory agency comparisons can be of more value and facilitate improvements if conducted among countries with common challenges and similar health agency characteristics. A study was conducted to compare the registration review model used by the Turkish Medicines and Medical Devices Agency (Türkiye Ilaç ve Tibbi Cihaz Kurumu; TITCK) with those of four similar-sized regulatory agencies to identify areas of strength and those requiring further improvement within the TITCK in relation to the review process as well as to assess the level of adherence to good review practices (GRevP) in order to facilitate the TITCK progress toward agency goals...
2018: Frontiers in Pharmacology
Laís F Berro, Sergio B Tufik, Roberto Frussa-Filho, Monica L Andersen, Sergio Tufik
Sleep deprivation (SD) and amphetamine use are commonly associated conditions. SD shares similar neurobiological effects with psychostimulants, playing an important role in drug addiction, especially through conditioning manipulations. The aim of the present study was to investigate the effects of SD on the development of amphetamine-induced conditioned place preference (CPP) in a protocol with a reduced number of conditioning sessions. Male adult Wistar rats were submitted to 4 conditioning sessions (2 sessions/day) in the CPP apparatus, half with saline (non-drug-paired compartment) and half with 2 mg/kg amphetamine (drug-paired compartment) after control (home-cage maintained) or SD (6 h gentle handling method) conditions...
February 6, 2018: Neuroscience Letters
Jee-Yeon Seo, Yong-Hyun Ko, Shi-Xun Ma, Bo-Ram Lee, Seok-Yong Lee, Choon-Gon Jang
The studies for the effects of stress on drug addiction were mostly obtained using sequential exposure to stress and drugs. However, few studies have been conducted on the effects of simultaneous exposure to stress and methamphetamine (METH) on METH-induced reward effects and behavioral sensitization. Thus, we examined the effects of simultaneous exposure to restraint stress and METH on METH-induced addictive behaviors using conditioned place preference (CPP) in mice. During the conditioning period, the mice were exposed to 2 h restraint stress before administration of METH or saline for 4 days...
February 5, 2018: Brain Research Bulletin
Ninna Nielsen, Peter Vedsted, Henry Jensen
Introduction: Many countries have implemented cancer patient pathways (CPPs) for organ-specific cancers. However, due to high symptom diversity, it can be difficult for the General Practitioner (GP) to decide on the appropriate CPP. Objective: The aim of this study was to estimate the proportion of patients who were referred to a second CPP, were diagnosed with cancer or died within 6 months after receiving a negative result from clinical investigation through an initial CPP...
February 6, 2018: Family Practice
John J Kiernicki, Caleb J Tatebe, Matthias Zeller, Suzanne C Bart
Uranium mono(imido) species have been prepared via the oxidation of Cp*U( Mes PDI Me )(THF) (1-Cp*) and [Cp P U( Mes PDI Me )] 2 (1-Cp P ), where Cp* = η 5 -1,2,3,4,5-pentamethylcyclopentadienide, Cp P = 1-(7,7-dimethylbenzyl)cyclopentadienide, Mes PDI Me = 2,6-[(Mes)N═CMe] 2 C 5 H 3 N, and Mes = 2,4,6-trimethylphenyl, with organoazides. Treating either with N 3 DIPP (DIPP = 2,6-diisopropylphenyl) formed uranium(IV) mono(imido) complexes, Cp P U(NDIPP)( Mes PDI Me ) (2-Cp P ) and Cp*U(NDIPP)( Mes PDI Me ) (2-Cp*), featuring reduced [ Mes PDI Me ] - ...
February 8, 2018: Inorganic Chemistry
Sahrish Rehmani, James E Dixon
Oral delivery of insulin and other anti-diabetic peptides is inhibited by low intestinal absorption caused by the poor permeability across cellular membranes and the susceptibility to enzymatic degradation in the gastrointestinal tract. Cell-penetrating peptides (CPPs) have been investigated for a number of years as oral absorption enhancers for hydrophilic macromolecules by electrostatic or covalent conjugation on in conjunction with nanotechnology. Endogenous cellular uptake mechanisms present in the intestine can be exploited by engineering peptide conjugates that transcytose; entering cells by endocytosis and leaving by exocytosis...
February 2018: Peptides
Luisa Vera Muscatello, Giancarlo Avallone, Fabienne Serra, Torsten Seuberlich, Maria Teresa Mandara, Silvia Sisó, Barbara Brunetti, Anna Oevermann
Choroid plexus tumors (CPT) are intraventricular neoplasms accounting for 10% of all primary central nervous system tumors in dogs. They are frequently classified according to the human WHO classification into choroid plexus papilloma (CPP, grade I), atypical CPP (aCPP, grade II), and choroid plexus carcinoma (CPC, grade III). Histological features observed in canine CPT such as increased vascular density (IVD) and glomeruloid microvascular proliferation (GMVP) are not part of the WHO classification. This multi-centric study aimed to investigate tumor-associated vascular hyperplasia in dogs by determining the prevalence of GMVP and IVD in 52 canine CPT and their association with tumor grade...
January 1, 2018: Veterinary Pathology
Patrick J Cosme, Jing Ye, Shalondria Sears, Ewa P Wojcikiewicz, Andrew C Terentis
Cell-penetrating peptides (CPPs) are promising vectors for the intracellular delivery of a variety of membrane-impermeable bioactive compounds. The mechanisms by which CPPs cross the cell membrane, and the effects that CPPs may have on cell function, still remain to be fully clarified. In this work we employed confocal Raman microscopy (CRM) and atomic force microscopy (AFM) to study the infiltration and physiological effects of the amphipathic CPP, transportan (Tp), on a metastatic melanoma cell line, SK-Mel-2...
February 5, 2018: Molecular Pharmaceutics
Matias A Via, Mario G Del Popolo, Natalia Wilke
Cell penetrating peptides (CPPs) are polycationic sequences of amino-acids recognised as some of the most effective vehicles for delivering membrane impermeable cargos into cells. CPPs can traverse cell membranes by direct translocation, and assessing the role of the lipids on the membrane permeation process is important to convene a complete model of the CPP translocation. In this work we focus on the biophysical basis of peptide-fatty acid interactions, analyzing how the acid-base and electrostatic prop- erties of the lipids determine the CPP adsorption and incorporation into a Langmuir monolayer, focusing thus on the first two stages of the direct translocation mechanism...
February 2, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Matías A Via, Joaquín Klug, Natalia Wilke, Luis S Mayorga, M G Del Pópolo
Cell-penetrating peptides (CPP) are short sequences of cationic amino-acids that show a surprising ability to traverse lipid bilayers. CPP are considered to be some of the most effective vectors to introduce membrane-impermeable cargos into cells, but the molecular basis of the membrane translocation mechanisms and its dependence on relevant membrane physicochemical properties have yet to be fully determined. In this paper we resort to Molecular Dynamics simulations and experiments to investigate how the electrostatic potential across the lipid/water interface affects the insertion of hydrophilic and amphipathic CPP into two-dimensional lipid structures...
February 2, 2018: Physical Chemistry Chemical Physics: PCCP
Katy Vincent, Andrew Baranowski, Siladitya Bhattacharya, Judy Birch, Ying Cheong, Roman Cregg, Jane Daniels, Catherine A Hewitt, Gary J Macfarlane, Lee Middleton, Wojciech Szubert, Irene Tracey, Amanda C de C Williams, Andrew W Horne
INTRODUCTION: Chronic pelvic pain (CPP) affects more than 1 million UK women with associated healthcare costs of £158 million annually. Current evidence supporting interventions when no underlying pathology is identified is very limited and treatment is frequently inadequate. Gabapentin (a GABA analogue) is efficacious and often well tolerated in other chronic pain conditions. We have completed a successful pilot randomised controlled trial Gabapentin for Pelvic Pain 1 (GaPP1) and here describe the protocol for our definitive multicentre trial to assess the efficacy of gabapentin in the management of CPP in women Gabapentin for Pelvic Pain 2 (GaPP2)...
January 31, 2018: BMJ Open
Carmen Ferrer-Pérez, Marina D Reguilón, Carmen Manzanedo, M Asunción Aguilar, José Miñarro, Marta Rodríguez-Arias
Numerous studies have shown that social defeat stress induces an increase in the rewarding effects of cocaine. In this study we have investigated the role played by the main hypothalamic stress hormone, corticotropin-releasing factor (CRF), in the effects that repeated social defeat (RSD) induces in the conditioned rewarding effects and locomotor sensitization induced by cocaine. A total of 220 OF1 mice were divided into experimental groups according to the treatment received before each social defeat: saline, 5 or 10mg/kg of the nonpeptidic corticotropin-releasing factor CRF1 receptor antagonist CP-154,526, or 15 or 30µg/kg of the peptidic corticotropin-releasing factor CRF2 receptor antagonist Astressin2-B...
January 29, 2018: European Journal of Pharmacology
Noriyasu Kamei, Chikako Shigei, Ryota Hasegawa, Mariko Takeda-Morishita
This present study aimed to determine the optimal oral insulin delivery conditions that would maximize the utility of cell-penetrating peptides (CPPs) by using a noncovalent strategy. We first compared the effectiveness of two potential CPPs, penetratin and its analog PenetraMax, as absorption enhancers for insulin. The combined effect was evaluated under in vivo oral administration conditions. Both D-forms of CPPs were highly effective for increasing the oral absorption of insulin, and D-PenetraMax showed a more rapid onset of absorption enhancement effects compared with those of D-penetratin...
2018: Biological & Pharmaceutical Bulletin
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