keyword
MENU ▼
Read by QxMD icon Read
search

Infectious bursal disease virus

keyword
https://www.readbyqxmd.com/read/29046449/gga-mir-130b-suppresses-infectious-bursal-disease-virus-replication-via-targeting-the-viral-genome-and-cellular-socs5
#1
Mengjiao Fu, Bin Wang, Xiang Chen, Zhiyuan He, Yongqiang Wang, Xiaoqi Li, Hong Cao, Shijun J Zheng
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post transcriptionally through silencing or degrading its targets, playing important roles in immune response. However, the role of miRNAs in host response against infectious bursal disease virus (IBDV) infection is not clear. In this study, we show that the expression of a series of miRNAs was significantly altered in DF-1 cells after infectious bursal disease virus (IBDV) infection. We found that gga-miR-130b inhibited IBDV replication via targeting the specific sequence of IBDV segment A and enhanced the expression of IFN-β by targeting Suppressors of Cytokine Signaling 5(SOCS5) in host cells...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29039212/propagation-and-titration-of-infectious-bursal-disease-virus-including-non-cell-culture-adapted-strains-using-ex-vivo-stimulated-chicken-bursal-cells
#2
Sebastien Mathieu Soubies, Céline Courtillon, Mouna Abed, Michel Amelot, Alassane Keita, Andrew Broadbent, Sonja Härtle, Bernd Kaspers, Nicolas Eterradossi
Infectious bursal disease virus (IBDV) is a Birnaviridae family member of economic importance for poultry. This virus infects and destroys developing B lymphocytes in the cloacal bursa, resulting in a potentially fatal or immunosuppressive disease in chickens. Naturally-occurring viruses and many vaccine strains are not able to grow in in vitro systems without prior adaptation, which process often affects viral properties such as virulence. Primary bursal cells, which are the main target cells of lymphotropic IBDV in vivo, may represent an attractive system for the study of IBDV...
October 17, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28988058/the-down-regulation-of-casein-kinase-1-alpha-as-a-host-defense-response-against-infectious-bursal-disease-virus-infection
#3
Lizhou Zhang, Hui Li, Yuming Chen, Xiang Gao, Zhen Lu, Li Gao, Yongqiang Wang, Yulong Gao, Honglei Gao, Changjun Liu, Hongyu Cui, Yanping Zhang, Qing Pan, Xiaole Qi, Xiaomei Wang
Infectious bursal disease virus (IBDV) is an important immunosuppressive virus of chickens. Although the gene functions of IBDV have been well characterized, the host responses during IBDV infection remain much poor. In the present study, casein kinase 1 alpha (CK1α), a novel VP2-associated protein, was down-regulated during IBDV replication in DF1 cells. Further experiments showed that siRNA-mediated knockdown of CK1α inhibited IBDV replication, while overexpression of CK1α promoted IBDV growth. Finally, we revealed that the effects of CK1α expression level on IBDV replication were involved in the negative regulation of CK1α on type I interferon receptor (IFNAR1), because ubiquitination assay analyses demonstrated that CK1α could promote the ubiquitination of IFNAR1, thereby affecting the stability of this receptor...
October 4, 2017: Virology
https://www.readbyqxmd.com/read/28972403/detection-of-different-genotypes-of-infectious-bronchitis-virus-and-of-infectious-bursal-disease-virus-in-european-broilers-during-an-epidemiological-study-in-2013-and-the-consequences-for-the-diagnostic-approach
#4
J J de Wit, C Cazaban, R Dijkman, G Ramon, Y Gardin
To gather recent data regarding the infectious bronchitis (IB) and infectious bursal disease (IBD) situation in Europe, a large-scale field epidemiological survey using diagnostic samples has been implemented in 2013 for about six months in several European countries: France, Germany, Greece, Italy, the Netherlands, Poland, Portugal, the Republic of Ireland, Spain and the United Kingdom. In 234 flocks that were sampled, strains from 10 different IBV genotypes were detected: the 793B genotype was detected most frequently, followed by QX, Massachusetts (Mass) and the Xindadi-like strains...
October 3, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28954433/newcastle-disease-virus-vectored-bivalent-vaccine-against-virulent-infectious-bursal-disease-and-newcastle-disease-of-chickens
#5
Sohini Dey, Madhan Mohan Chellappa, Dinesh C Pathak, Satish Gaikwad, Kalpana Yadav, Saravanan Ramakrishnan, Vikram N Vakharia
Newcastle disease virus (NDV) strain F is a lentogenic vaccine strain used for primary vaccination in day-old chickens against Newcastle disease (ND) in India and Southeast Asian countries. Recombinant NDV-F virus and another recombinant NDV harboring the major capsid protein VP2 gene of a very virulent infectious bursal disease virus (IBDV); namely rNDV-F and rNDV-F/VP2, respectively, were generated using the NDV F strain. The rNDV-F/VP2 virus was slightly attenuated, as compared to the rNDV-F virus, as evidenced from the mean death time and intracerebral pathogenicity index analysis...
September 26, 2017: Vaccines
https://www.readbyqxmd.com/read/28921008/molecular-characterization-of-very-virulent-infectious-bursal-disease-virus-strains-circulating-in-egypt-from-2003-to-2014
#6
Awad A Shehata, Hesham Sultan, Mohammed Y Halami, Shaimaa Talaat, Thomas W Vahlenkamp
In the present study, four very virulent infectious bursal disease virus (vvIBDV) isolates from flocks of chickens with vaccination failure in Egypt in 2003, 2007, 2010 and 2014 were characterized. The four viruses, designated USC2003, USC2007, USC2010 and USC2014, were detected by reverse transcription PCR, subjected to sequencing of both genomic segments (A and B) and compared with geographically and phylogenetically diverse IBDV strains. Phylogenetic analysis of segment A (complete) and B (partial) revealed a close relationship between Egyptian and vvIBDV reference strains of European and Asian origin...
September 18, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28839013/genome-sequence-of-a-novel-reassortant-and-very-virulent-strain-of-infectious-bursal-disease-virus
#7
Hyun-Jeong Lee, Il Jang, Sun-Hwa Shin, Hee-Soo Lee, Kang-Seuk Choi
Here, we report the complete coding genome sequence of a novel reassortant and very virulent infectious bursal disease virus (IBDV), designated JBN2011. Characterization of the JBN2011 genome suggests that it is a rare recombinant virus having a very virulent IBDV segment A and a Bursine-2-like attenuated IBDV segment B.
August 24, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28826238/pair-epitopes-vaccination-enabling-offspring-vaccination-in-the-presence-of-maternal-antibodies
#8
Jacob Pitcovski, Eli Pitcovski, Dana Goldenberg, Ehud Shahar
Maternally derived antibodies (MDAs) are critical for offspring protection during the first days of life. However, due to their short half-life (3-5 days), MDA levels decline rapidly and by 8-15 days post-hatch drop to below protective levels. In addition, MDAs against a specific pathogen often impede the efficient protective immune response to that pathogen by the new-born following vaccination. The combination of these two phenomena generates a gap in protection in the period between loss of MDA protection and development of vaccine-induced protective antibodies...
August 22, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28769911/vp2-of-infectious-bursal-disease-virus-induces-apoptosis-via-triggering-oral-cancer-overexpressed-1-oraov1-protein-degradation
#9
Yao Qin, Zhichao Xu, Yongqiang Wang, Xiaoqi Li, Hong Cao, Shijun J Zheng
Infectious bursal disease (IBD) is an acute, highly contagious and immunosuppressive avian disease caused by IBD virus (IBDV). Cell apoptosis triggered by IBDV contributes to the dysfunction of immune system in host. VP2 of IBDV is known to induce cell death but the underlying mechanism remains unclear. Here we demonstrate that VP2 interacts with the oral cancer overexpressed 1 (ORAOV1), a potential oncoprotein. Infection by IBDV or ectopic expression of VP2 causes a reduction of cellular ORAOV1 and induction of apoptosis, so does knockdown of ORAOV1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28620682/infectious-bursal-disease-outbreak-investigation-molecular-characterization-and-vaccine-immunogenicity-trial-in-ethiopia
#10
Aregitu Mekuriaw, Molalegne Bitew, Esyas Gelaye, Bedaso Mamo, Gelagay Ayelet
The study was conducted with the objective of isolation and molecular characterization of infectious bursal disease virus (IBDV) circulating in Ethiopia and to assess the immunogenicity of different commercially available live attenuated IBD vaccines and finally to select the appropriate vaccine strain for the existing IBDV. Outbreak samples collected from different poultry farms with IBD infection between 2013 and 2015 were used for the virus isolation and molecular characterization. IBD vaccine immunogenicity test was conducted using four different commercially available live attenuated IBD vaccine strains: namely D78, B2K, LC75, and EXTREM...
August 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28619162/impact-of-treatments-for-recycled-broiler-litter-on-the-viability-and-infectivity-of-microorganisms
#11
Daiane Voss-Rech, Iara Maria Trevisol, Liana Brentano, Virgínia Santiago Silva, Raquel Rebelatto, Fátima Regina Ferreira Jaenisch, Cintia Hiromi Okino, Marcos Antonio Zanella Mores, Arlei Coldebella, Sônia de Avila Botton, Clarissa Silveira Luiz Vaz
The microbiological risk of recycled litter depends on the efficacy of the management system applied to inactivate residual microorganisms and preserve the health of the successive broiler flock. This study aimed to assess the viability and infectivity of the Newcastle Disease Virus (NDV), Infectious Bursal Disease Virus (IBDV) and Salmonella Heidelberg in recycled litter exposed to different treatments. The litter was contaminated with microorganisms and submitted to the treatments (T): T1: shallow fermentation; T2: quicklime (calcium oxide); T3: shallow fermentation followed by addition of quicklime; T4: no treatment...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28603519/antigen-sparing-and-enhanced-efficacy-of-multivalent-vaccines-adjuvanted-with-immunopotentiators-in-chickens
#12
Peipei Wu, Jihu Lu, Lei Feng, Hongzhuan Wu, Xuehua Zhang, Mei Mei, Jibo Hou, Xiufan Liu, Yinghua Tang
We previously described that immunopotentiators, CVCVA5, increased the efficacy of H5 and H9 subtype avian influenza vaccines in chickens, ducks, and geese. In this study, we further investigated the effects of the CVCVA5 for improving the efficacy of other univalent or multivalent inactivated vaccines. The immune response administrated with half-dose of monovalent vaccine plus CVCVA5 were higher than those of one dose of monovalent vaccine without immunopotentiators as measured by levels of antibodies from serum, tears and bronchoalveolar lavage fluids, and cytokines of IFNγ and IL-4 from serum...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28592532/voltage-dependent-anion-channel-1-interacts-with-ribonucleoprotein-complexes-to-enhance-infectious-bursal-disease-virus-polymerase-activity
#13
Chunyan Han, Xiangwei Zeng, Shuai Yao, Li Gao, Lizhou Zhang, Xiaole Qi, Yulu Duan, Bo Yang, Yulong Gao, Changjun Liu, Yanping Zhang, Yongqiang Wang, Xiaomei Wang
Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus. Segment A contains two overlapping open reading frames (ORFs), which encode viral proteins VP2, VP3, VP4, and VP5. Segment B contains one ORF and encodes the viral RNA-dependent RNA polymerase, VP1. IBDV ribonucleoprotein complexes are composed of VP1, VP3, and dsRNA and play a critical role in mediating viral replication and transcription during the virus life cycle. In the present study, we identified a cellular factor, VDAC1, which was upregulated during IBDV infection and found to mediate IBDV polymerase activity...
August 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28523925/genetic-and-pathologic-characteristics-of-infectious-bursal-disease-viruses-isolated-from-broiler-chickens-in-iran-during-2014-2015
#14
H Norouzian, G Farjanikish, H Hosseini
Infectious bursal disease (IBD) virus causes a highly contagious immunosuppressive disease in chickens. A total number of 12 pooled bursal samples were collected during 2014-2015 from broiler farms in different regions of Iran. Typical macroscopical and histopathological lesions of the bursa of Fabricius were found similar to reports by other researchers. A 474-bp part of hypervariable region of VP2 (hvVP2) was sequenced and analyzed. Ten isolates had the characteristic amino acid residues of very virulent IBD (vvIBD) viruses and the other two were identified as attenuated (vaccine) strains...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28495316/effect-of-infectious-bursal-disease-ibd-vaccine-on-salmonella-enteritidis-infected-chickens
#15
Nagah Arafat, Abdelfattah H Eladl, Hebatallah Mahgoub, Reham A El-Shafei
BACKGROUND: Chickens infected with both infectious bursal disease virus (IBDV) and Salmonella had higher mortality. In this work, we investigated the effect of IBDV vaccine (modified live-virus bursal disease vaccine, Nobilis strain 228E®) on experimentally infected chickens with Salmonella Enteritidis (SE). METHODS: Four experimental groups were included in this study, negative control group, 228E®group, 228E®+SE infected group, and SE infected group. Chickens were ocularly administrated 228E® at 12days of age and orally infected with S...
June 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28494932/comparison-of-growth-performance-and-immune-parameters-of-three-commercial-chicken-lines-used-in-organic-production
#16
COMPARATIVE STUDY
R B Kjærup, H R Juul-Madsen, L R Norup, P Sørensen, T S Dalgaard
Owing to the higher demands for avoiding medication and antibiotics, health status of the production animals plays an important role in the poultry industry, especially in organic poultry systems. Immunity plays a major role in keeping the host free from disease, and it is evident that the host's genetic make-up influences immunity and disease resistance/susceptibility in chickens. Previously, breeding strategies aimed at selection for resistance against specific diseases with the risk of creating less disease resistance against other pathogens...
May 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28486945/transcription-profiles-of-the-responses-of-chicken-bursae-of-fabricius-to-ibdv-in-different-timing-phases
#17
Changbo Ou, Qiuxia Wang, Yanhong Zhang, Weili Kong, Shouping Zhang, Yan Yu, Jinyou Ma, Xingyou Liu, Xianghui Kong
BACKGROUND: Infectious bursal disease virus (IBDV) infection causes immunosuppression in chickens and increases their susceptibility to secondary infections. To explore the interaction between host and IBDV, RNA-Seq was applied to analyse the transcriptional profiles of the responses of chickens' bursas of Fabricius in the early stage of IBDV infection. RESULTS: The results displayed that a total of 15546 genes were identified in the chicken bursa libraries. Among the annotated genes, there were 2006 and 4668 differentially expressed genes in the infection group compared with the mock group on day 1 and day 3 post inoculation (1 and 3 dpi), respectively...
May 10, 2017: Virology Journal
https://www.readbyqxmd.com/read/28482266/a-recombinant-avian-antibody-against-vp2-of-infectious-bursal-disease-virus-protects-chicken-from-viral-infection
#18
Yingjie Zhang, Jiechao Yin, Tianhe Li, Bing Zhou, Pengfei Xu, Ruixiang Che, Yunye Liu, Hongxue Cao, Xianlong Ye, Yongbi Yang, Xiaole Qi, Shimin Zheng, Guojie Ding, Guiping Ren, Hanchun Yang, Xiaomei Wang, Deshan Li
A stable cell-line was established that expressed the recombinant avian antibody (rAb) against the infectious bursal disease virus (IBDV). rAb exhibited neutralization activity to IBDV-B87 strain in DF1 cells. The minimum rAb concentration required for inhibition of the cytopathic effect (CPE) was 1.563μg/mL. To test the efficacy of rAb, a 168-h cohabitation challenge experiment was performed to transmit the disease from the chickens challenged with vvIBDV (HLJ0504 strain) to three test groups of chickens, i...
April 8, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28447468/induction-of-apoptosis-in-the-bursa-of-fabricius-by-vaccination-against-gumboro-disease
#19
Marcelo Pablo Killian, Juan David Boviez, Mariana Gambarotta, Daniel Marcelo Lombardo
Infectious bursal disease is a severe acute viral disease of young chickens, affecting mainly the B-lymphocytes in the bursa of Fabricius, leading to severe immunosuppression as a result of the death of lymphoid cells. In the bursa infected with infectious bursal disease virus, viral replication is associated with apoptosis of lymphoid cells, inflammatory change and atrophy. Vaccination has appeared to be a crucial factor for control, with live attenuated vaccines being the most used. However, the apoptotic effect of these vaccines on the bursa has not been tested...
October 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28447340/marginal-deficiencies-of-dietary-arginine-and-methionine-could-suppress-growth-performance-and-immunological-responses-in-broiler-chickens
#20
R Jahanian, M Khalifeh-Gholi
The present study was conducted to investigate the effects of different levels of dietary arginine (Arg) and methionine (Met) on performance, immune responses, and carcass characteristics of broiler chickens. A total of 540 day-old Ross 308 broiler chicks were randomly assigned into the nine experimental diets, consisting five replicates of 12 birds each. Dietary treatments included three different levels (90%, 100%, and 110% of National Research Council [NRC] specifications) of either dietary Arg or Met, which were fed to the birds according to a 3 × 3 factorial arrangement of treatments during a 42 days feeding trial...
April 26, 2017: Journal of Animal Physiology and Animal Nutrition
keyword
keyword
771
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"