keyword
MENU ▼
Read by QxMD icon Read
search

Infectious bursal disease virus

keyword
https://www.readbyqxmd.com/read/27924642/development-of-an-rt-qpcr-assay-for-the-specific-detection-of-a-distinct-genetic-lineage-of-the-infectious-bursal-disease-virus
#1
Gonzalo Tomás, Martín Hernández, Ana Marandino, Claudia Techera, Sofia Grecco, Diego Hernández, Alejandro Banda, Yanina Panzera, Ruben Pérez
The infectious bursal disease virus (IBDV) is a major health threat to the world's poultry industry despite intensive controls including proper biosafety practices and vaccination. IBDV (Avibirnavirus, Birnaviridae) is a non-enveloped virus with a bisegmented double-stranded RNA genome. The virus is traditionally classified into classic, variant and very virulent strains, each with different epidemiological relevance and clinical implications. Recently, a novel worldwide spread genetic lineage was described and denoted as distinct (d) IBDV...
December 7, 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/27916318/advances-in-vaccine-research-against-economically-important-viral-diseases-of-food-animals-infectious-bursal-disease-virus
#2
Daral J Jackwood
Numerous reviews have been published on infectious bursal disease (IBD) and infectious bursal disease virus (IBDV). Many high quality vaccines are commercially available for the control of IBD that, when used correctly, provide solid protection against infection and disease caused by IBDV. Viruses are not static however; they continue to evolve and vaccines need to keep pace with them. The evolution of IBDV has resulted in very virulent strains and new antigenic types of the virus. This review will discuss some of the limitations associated with existing vaccines, potential solutions to these problems and advances in new vaccines for the control of IBD...
November 22, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27908832/evaluation-of-two-strains-of-marek-s-disease-virus-serotype-1-for-the-development-of-recombinant-vaccines-against-very-virulent-infectious-bursal-disease-virus
#3
Kai Li, Yongzhen Liu, Changjun Liu, Li Gao, Yulong Gao, Yanping Zhang, Hongyu Cui, Xiaole Qi, Li Zhong, Xiaomei Wang
Attenuated strains of Marek's disease virus serotype 1 (MDV1), and the closely related herpesvirus of turkeys, are among the most potent vectors for development of recombinant vaccines for poultry. To investigate the effects of MDV1 strain characteristics on the protective efficacy of the recombinant vaccines, we developed two recombinant MDV1 vaccines for expressing the VP2 gene of infectious bursal disease virus (IBDV) based on two different MDV1 strains, the attenuated strain 814 and the Meq gene-deleted recombinant MDV1 strain rLMS△Meq, as the viral vectors...
November 28, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27908831/eukaryotic-translational-initiation-factor-4aii-reduces-the-replication-of-infectious-bursal-disease-virus-by-inhibiting-vp1-polymerase-activity
#4
Li Gao, Kai Li, Li Zhong, Lizhou Zhang, Xiaole Qi, Yongqiang Wang, Yulong Gao, Xiaomei Wang
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). Although an interaction between eukaryotic translational initiation factor 4AII (eIF4AII) of the host and viral protein 1 (VP1), the RNA-dependent RNA polymerase (RdRp) of IBDV, has been established, the underlying effects of this interaction on IBDV and the molecular mechanism remain unclear. We here report that interaction of the host eIF4AII with VP1 inhibits the RNA polymerase activity of IBDV to reduce its replication in host cells...
November 28, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27902915/characterization-of-chicken-splenic-derived-dendritic-cells-following-vaccine-and-very-virulent-strains-of-infectious-bursal-disease-virus-infection
#5
A R Yasmin, S K Yeap, M Hair-Bejo, A R Omar
Studies have shown that infectious bursal disease virus (IBDV) infects lymphoid cells, mainly B cells and macrophages. This study was aimed to examine the involvement of chicken splenic-derived dendritic cells (ch-sDCs) in specific-pathogen-free chickens following inoculation with IBDV vaccine strain (D78) and a very virulent (vv) strain (UPM0081). Following IBDV infection, enriched activated ch-sDCs were collected by using the negative selection method and were examined based on morphology and immunophenotyping to confirm the isolation method for dendritic cells (DCs)...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902905/pathogenicity-of-genome-reassortant-infectious-bursal-disease-viruses-in-chickens-and-turkeys
#6
Daral J Jackwood, Simone T Stoute, Beate M Crossley
Infectious bursal disease virus (IBDV) contains two genome segments (segment A/segment B) that can reassort among the viruses. Reassortant IBDVs have been identified in several countries including the United States. These reassortant viruses usually include at least one genome segment from a very virulent (vv)IBDV strain. In vivo virulence of six reassortant IBDV from the United States was assessed relative to the virulence of three frequently described IBDV pathotypes: vvIBDV (rB strain), classic virulent (cv)IBDV (STC strain), and subclinical (sc)IBDV (Del-E strain)...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902904/infection-with-some-infectious-bursal-disease-virus-pathotypes-produces-virus-in-chicken-muscle-tissue-and-the-role-of-humoral-immunity-as-a-mitigation-strategy
#7
Mariana Sá E Silva, Kateri Bertran, Kira Moresco, Daral J Jackwood, David E Swayne
Infectious bursal disease virus (IBDV) causes important economic losses and negatively affects global trade in poultry and poultry products. This study determined the presence of IBDV in primary lymphoid tissues and muscle tissue of infected broilers and the role of vaccination as a mitigation strategy. In the first study, specific-pathogen-free (SPF) broiler chickens were challenged with STC (classical [cIBDV]), Indiana (variant [varIBDV]), rA (very virulent [vvIBDV]), or Ohio (serotype 2, avirulent) IBDV...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27897452/characterization-of-two-recombinant-hvt-ibd-vaccines-by-vp2-insert-detection-and-cell-mediated-immunity-after-vaccination-of-specific-pathogen-free-chickens
#8
Fiona Ingrao, Fabienne Rauw, Thierry van den Berg, Bénédicte Lambrecht
Infectious bursal disease (IBD) is an avian viral disease that causes severe economic losses in the poultry industry worldwide. The live IBD virus (IBDV) has a potential immunosuppressive effect. Currently available IBDV vaccines have shortcomings, prompting the development of safer and more effective vaccination approaches, including the use of the recombinant turkey herpesvirus vaccine expressing the immunogenic structural VP2 protein of IBDV (rHVT-IBD). The objectives of this study were twofold: (i) to develop in vitro assays and molecular tools to detect the VP2 protein and gene, and (ii) to evaluate cell-mediated immunity (CMI) induced by rHVT-IBD vaccination of day-old specific pathogen-free chickens...
November 29, 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/27881656/infectious-bursal-disease-virus-activates-c-src-to-promote-%C3%AE-4%C3%AE-1-integrin-dependent-viral-entry-via-modulating-downstream-akt-rhoa-gtpase-actin-rearrangement-cascade
#9
Chengjin Ye, Xinpeng Han, Zhaoli Yu, Enli Zhang, Lijuan Wang, Hebin Liu
: While the entry of IBDV is initiated by the binding of the virus to the two major receptors integrin and HSP90, the signaling events after the receptor binding and how they contribute to the viral entry remain elusive. We show here that IBDV activates c-Src by inducing phosphorylation of the Y416 residue in c-Src both in the DF-1 chicken fibroblasts and in vivo in the bursa of fabricius from SPF chickens. Importantly, the inactivated IBDV fails to stimulate c-Src Y416 phosphorylation, and a very virulent IBDV strain induces much higher level of c-Src Y416 phosphorylation than an attenuated strain...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27876199/comparison-of-homologous-and-heterologous-prime-boost-immunizations-combining-mva-vectored-and-plant-derived-vp2-as-a-strategy-against-ibdv
#10
Matías Richetta, Evangelina Gómez, María Soledad Lucero, Silvina Chimeno Zoth, María José Gravisaco, Gabriela Calamante, Analía Berinstein
Different immunogens such as subunit, DNA or live viral-vectored vaccines against Infectious Bursal Disease virus (IBDV) have been evaluated in the last years. However, the heterologous prime-boost approach using recombinant modified vaccinia Ankara virus (rMVA), which has shown promising results in both mammals and chickens, has not been tried against this pathogen yet. IBD is a highly contagious and immunosuppressive disease of poultry that affects mainly young chicks. It is caused by IBDV, a double-stranded RNA virus carrying its main antigenic epitopes on the capsid protein VP2...
November 18, 2016: Vaccine
https://www.readbyqxmd.com/read/27816055/genome-wide-profiling-of-chicken-dendritic-cell-response-to-infectious-bursal-disease
#11
Jian Lin, Jing Xia, Keyun Zhang, Qian Yang
BACKGROUND: Avian infectious bursal disease virus (IBDV) is a highly contagious, immunosuppressive disease of young chickens, which causes high mortality rates and large economic losses in the poultry industry. Dendritic cells (DCs), which are antigen-presenting cells, have the unique ability to induce both innate and acquired immune responses and may significantly influence virus pathogenicity. To understand the interaction between IBDV and DCs, a microarray was used to analyse the response of DCs infected by IBDV...
November 5, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27796116/health-evaluation-of-african-penguins-i-spheniscus-demersus-i-in-southern-africa
#12
Nola J Parsons, Tertius A Gous, Adam M Schaefer, Ralph E T Vanstreels
The African penguin (Spheniscus demersus) is an endangered seabird that breeds along the coast of Namibia and South Africa, and disease surveillance was identified as a priority for its conservation. Aiming for the establishment of baseline data on the presence of potential pathogens in this species, a comprehensive health assessment (blood smear examination, haematology, biochemistry and serology) was conducted on samples obtained from 578 African penguins at 11 breeding colonies and a rehabilitation centre...
September 20, 2016: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/27784860/characterization-of-variant-infectious-bursal-disease-virus-from-a-broiler-farm-in-japan-using-immunized-sentinel-chickens
#13
Kenichi Yamazaki, Hideyuki Ohta, Toru Kawai, Tsuyoshi Yamaguchi, Takeshi Obi, Kozo Takase
We attempted the isolation of variant infectious bursal disease (IBD) viruses by using sentinel chickens immunized with inactivated classical-type IBD vaccine. Immunized sentinel chickens with high levels of neutralizing antibodies and non-immunized sentinel chickens were raised together with broiler chickens in a commercial farm. Severe atrophy of the bursa of Fabricius was observed from the second week after cohabitation in non-immunized sentinel chickens. However, in immunized sentinel chickens and broiler chickens, atrophy was observed from the third week after cohabitation...
October 27, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27766900/pathogenicity-tissue-distribution-shedding-and-environmental-detection-of-two-strains-of-ibdv-following-infection-of-chickens-at-0-and-14-days-of-age
#14
Jayasundara Mudiyanselage Kanchana Ganga Kumari Jayasundara, Stephen William Walkden-Brown, Magaret Elizabeth Katz, A F M Fakhrul Islam, Katrin Gondola Renz, Jody McNally, Peter Hunt
Infectious bursal disease virus (IBDV) is endemic to most poultry-producing countries worldwide. Immunosuppressive classical and variant IBDV strains endemic to Australia are genetically distinct from other international strains. We report the results of infection experiments with Australian classical strain 06/95 and variant strain 02/95 in specific pathogen free (SPF) chickens. We tested the effects of strain and age of infection on bursal atrophy, viral RNA (vRNA) load in bursa of Fabricius (bursa), spleen, thymus, caecal tonsils, faeces, litter and exhaust dust as determined by real time reverse transcriptase polymerase chain reaction (qRT-PCR)...
October 21, 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/27742216/effects-of-different-promoters-on-the-protective-efficacy-of-recombinant-marek-s-disease-virus-type-1-expressing-the-vp2-gene-of-infectious-bursal-disease-virus
#15
Kai Li, Yongzhen Liu, Changjun Liu, Li Gao, Yanping Zhang, Yulong Gao, Hongyu Cui, Xiaole Qi, Li Zhong, Xiaomei Wang
The vaccine efficacy of recombinant viruses can be influenced by many factors. Accordingly, the activity of promoters has been one of the major factors affecting the antigen expression and protection rate. In the present study, two recombinant Marek's disease virus type 1 (MDV1) vaccines containing the VP2 gene of infectious bursal disease virus (IBDV) under control of different promoters were generated from overlapping fosmid DNAs. The rMDV-Pec-VP2 virus containing the VP2 gene under control of the Pec promoter (CMV enhancer and chicken β-actin chimera promoter) demonstrated higher VP2 expression and stronger antibody response against IBDV in chickens than the rMDV-CMV-VP2 virus using the CMV promoter...
October 11, 2016: Vaccine
https://www.readbyqxmd.com/read/27733779/a-5-year-study-of-the-incidence-and-economic-impact-of-variant-infectious-bursal-disease-viruses-on-broiler-production-in-saskatchewan-canada
#16
Tara Zachar, Shelly Popowich, Bob Goodhope, Tennille Knezacek, Davor Ojkic, Philip Willson, Khawaja Ashfaque Ahmed, Susantha Gomis
While the prevalence of infectious bursal disease virus (IBDV) on chicken farms in some provinces of Canada has been documented, the economic impact of variant IBDV infection on the broiler chicken industry in Saskatchewan has not. The objectives of this study were to identify the variant strains of IBDV circulating on Saskatchewan chicken farms and evaluate their economic impact on broiler production. Infection due to IBDV was detected in 43% of Saskatchewan chicken farms, with variant strains detected in infected birds closely related predominantly to NC171, 586, and Delaware-E...
October 2016: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/27705104/a-serosurvey-of-greater-sage-grouse-centrocercus-urophasianus-in-nevada
#17
Nancy L Sinai, Peter S Coates, Katelyn M Andrle, Chad Jefferis, C Gabriel Sentíes-Cué, Maurice E Pitesky
To better understand the potential avian diseases in Greater Sage-grouse ( Centrocercus urophasianus ) in the Great Basin in Nevada, we collected 31 blood samples March-April 2014 and tested for antibodies to eight viruses and two bacteria. Specifically, sera were tested for antibodies to avian leukosis virus type A, B, and J (ALV-A, ALV-B, and ALV-J, respectively), infectious bursal disease virus, infectious bronchitis virus, reticuloendothelial virus, avian influenza virus (AIV), West Nile virus, Pasteurella multocida (PM), and Salmonella enterica serovar Pullorum...
October 5, 2016: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/27692095/screening-scfv-antibodies-against-infectious-bursal-disease-virus-by-co-expression-of-antigen-and-antibody-in-the-bacteria-display-system
#18
Xiaochen Guo, Hongxue Cao, Yunxin Wang, Yang Liu, Yanmin Chen, Nan Wang, Shan Jiang, Shengqi Zhang, Qiang Wu, Tianhe Li, Yingjie Zhang, Bing Zhou, Jiechao Yin, Deshan Li, Guiping Ren
We have previously reported an antigen and antibody co-expression (AAC) technology to demonstrate the interaction between a known antigen and antibody. To validate the co-expression system for screening antibody libraries, a single chain fragment variable(scFv)antibody library was constructed from chickens immunized with the VP2 protein of infectious bursal disease virus (IBDV). The genes of both VP2 and scFv antibodies were inserted into the pBFD-Ab-Ag vector. The co-expression library was subjected to three rounds of screening by flow cytometry (FCM) using a polyclonal antibody against VP2 through a bacteria display system...
November 1, 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27663370/circulating-strains-of-variant-infectious-bursal-disease-virus-may-pose-a-challenge-for-antibiotic-free-chicken-farming-in-canada
#19
Shanika Kurukulsuriya, Khawaja Ashfaque Ahmed, Davor Ojkic, Thushari Gunawardana, Ashish Gupta, Kalhari Goonewardene, Ruwani Karunaratne, Shelly Popowich, Philip Willson, Suresh K Tikoo, Susantha Gomis
Antibiotic-free and safe animal products are most desirable among consumers. However, ensuring safe poultry products is a challenging task when the chicken immune system is compromised. Infectious bursal disease virus (IBDV) causes immunosuppression and predisposes chickens to secondary infections. Breeder vaccination against IBDV is routinely practiced for producing chicks with maternally-derived antibody (MAb) to prevent infection in newly hatched chicks. The majority of IBDV circulating in Canadian farms are variant strains (vIBDV)...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27659678/infectious-bursal-disease-virus-as-a-replication-incompetent-viral-vector-expressing-green-fluorescent-protein
#20
Yung-Yi C Mosley, Ching Ching Wu, Tsang Long Lin
Infectious bursal disease virus (IBDV) has been established as a replication-competent viral vector capable of carrying an epitope at multiple loci in the genome. To enhance the safety and increase the insertion capacity of IBDV as a vector, a replication-incompetent IBDV vector was developed in the present study. The feasibility of replacing one of the viral gene loci, including pvp2, vp3, vp1, or the polyprotein vp243, with the sequence of green fluorescent protein (GFP) was explored. A method combining TCID50 and immunoperoxidase monolayer assay (IPMA) determined the most feasible locus for gene replacement to be pvp2...
September 22, 2016: Archives of Virology
keyword
keyword
771
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"