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Infectious bursal disease virus

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https://www.readbyqxmd.com/read/30239915/cc-chemokine-ligand-19-might-act-as-the-main-bursal-t-cell-chemoattractant-factor-during-ibdv-infection
#1
Qiuxia Wang, Changbo Ou, Xiaobing Wei, Yan Yu, Jinqing Jiang, Yanhong Zhang, Jinyou Ma, Xingyou Liu, Gaiping Zhang
Infectious bursa disease virus (IBDV) pathogenesis is characterized by increased numbers of T cells and decreased numbers of B cells in the bursa. Currently, little is about the key factor that affects T migration into bursa. In humans, CC chemokine ligand 19 (CCL19) recruits monocytes and neutrophils and is usually involved in various inflammatory disorders. The aim of this study was to assess the roles of CCL19 in driving peripheral blood cells infiltration into bursa of Fabricius of chickens infected with IBDV...
September 17, 2018: Poultry Science
https://www.readbyqxmd.com/read/30223836/novel-protein-chip-for-the-detection-of-antibodies-against-infectious-bronchitis-virus
#2
Liping Yan, Jianhua Hu, Jing Lei, Zhiyu Shi, Qian Xiao, Zhenwei Bi, Lu Yao, Yuan Li, Yuqing Chen, An Fang, Hui Li, Suquan Song, Min Liao, Jiyong Zhou
BACKGROUND: Infectious bronchitis (IB) caused by the IB virus (IBV) can cause acute damage to chickens around the world. Therefore, rapid diagnosis and immune status determination are critical for controlling IBV outbreaks. Enzyme-linked immunosorbent assays (ELISAs) have been widely used in the detection of IBV antibodies in the early infection and continuous infection of IB because they are more sensitive and quicker than other diagnostic methods. RESULTS: We have developed two indirect microarray methods to detect antibodies against IBV: a chemiluminescent immunoassay test (CIT) and a rapid diagnostic test (RDT)...
September 17, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/30208951/identification-and-assessment-of-virulence-of-a-natural-reassortant-of-infectious-bursal-disease-virus
#3
Anna Pikuła, Anna Lisowska, Agnieszka Jasik, Krzysztof Śmietanka
Infectious bursal disease virus (IBDV) is one of the most important immunosuppressive viral agents in poultry production. Prophylactic vaccinations of chicken flocks are the primary tool for disease control. Widely used immunoprophylaxis can, however, provide high pressure which contributes to the genetic diversification of circulating viruses, e.g. through reassortment of genome segments. We report the genetic and phenotypic characterization of a field reassortant IBDV (designated as Bpop/03) that acquired segment A from very virulent IBDV and segment B from classical attenuated D78-like IBDV...
September 12, 2018: Veterinary Research
https://www.readbyqxmd.com/read/30207739/field-and-laboratory-findings-following-the-large-scale-use-of-intermediate-type-infectious-bursal-disease-vaccines-in-denmark
#4
L Olesen, R Dijkman, R Koopman, R van Leeuwen, Y Gardin, R M Dwars, N D de Bruijn, G J Boelm, J Elattrache, J J de Wit
Following a period of clinical outbreaks of very virulent infectious bursal disease virus (vvIBDV) in Denmark, the histological bursal lesion score (HBLS) was used on a national scale to screen broiler flocks vaccinated with intermediate IBD vaccines for lesions indicative of IBDV challenge. High lesion scores were detected in a high percentage of healthy and well performing flocks despite the lack of other indications of the presence of vvIBDV. RT-PCR and subsequent sequencing showed the frequent presence of H253Q and H253N IBDV strains that were genetically close to the sequence of the intermediate vaccines with a relative risk ratio of 13...
September 12, 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/30145255/pro-apoptosis-effects-of-protocatechuic-acid-in-the-early-stage-of-infectious-bursal-disease-virus-infection
#5
Changbo Ou, Qiuxia Wang, Xiaobing Wei, Mingcheng Liu, Xingyou Liu, Cheng He
Infectious bursal disease virus (IBDV) is a very important small RNA virus in the family of Birnaviridae, which can cause severe immunosuppressive effects and pathological damages in young chickens. It can replicate in bursal lymphocytes and impede the growth and development of B cells, finally causing bursal lymphocytes apoptosis. Previous results have shown that protocatechuic acid (PCA) as an important phenolic compound could effectively improve the survival rate of chickens infected with IBDV. The current study aimed to explore how PCA influenced the pathogenesis of IBDV, especially lymphocyte apoptosis in the process of IBDV infection...
August 24, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30118165/immunogenicity-and-protective-efficacy-of-orally-administered-recombinant-lactobacillus-plantarum-expressing-vp2-protein-against-ibdv-in-chicken
#6
Maqsood Iram, Wen Shi, Lan Wang, Xiaona Wang, Bing Han, Haiyuan Zhao, Abbas Muhammad Nadeem, Bukhari Syed Moshin, Kausar Saima, Shah Syed Jamal, Mufti Farees Ud Din, Yigang Xu, Lijie Tang, Yijing Li
AIM: To develop an effective oral vaccine against the very virulent infectious bursal disease virus (vvIBDV), we generated two recombinant Lactobacillus plantarum strains (pPG612-VP2/LP and pPG612-T7g10-VP2/LP, which carried the T7g10 translational enhancer) that displayed the VP2 protein on the surface, and compared the humoral and cellular immune responses against vvIBDV in chickens. METHODS AND RESULTS: We genetically engineered the Lactobacillus plantarum strains pPG612-VP2/LP and pPG612-T7g10-VP2/LP constitutively expressing the VP2 protein of vvIBDV...
August 17, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/30107600/effects-of-ibdv-infection-on-expression-of-ghrelin-and-ghrelin-related-genes-in-chicken
#7
Y Yu, Y H Zhang, Z Y Xu, T Y Liu, Q X Wang, C B Ou, J Y Ma
Ghrelin is a peptide hormone that plays a modulatory role in the immune system. Studies have demonstrated that mammal ghrelin level is influenced by pathological status. However, it has not been reported whether chicken ghrelin level changes during pathogen infection. This study was designed to investigate changes of ghrelin levels in chickens infected with infectious bursal disease virus (IBDV) and to explore the relationship between ghrelin changes and bursal damage, and inflammatory cells infiltration induced by IBDV...
August 13, 2018: Poultry Science
https://www.readbyqxmd.com/read/30086652/a-proposed-nomenclature-for-infectious-bursal-disease-virus-isolates
#8
Daral J Jackwood, Karel A Schat, Linda O Michel, Sjaak de Wit
Infectious bursal disease virus (IBDV) was initially identified in the USA. For decades, these viruses were not categorized using a typing system because they were considered to be antigenically and pathogenically similar. In the 1980s, a second major serotype, serotype 2, was found in turkeys. Classification of IBDV became more complex with the discovery of antigenic variant strains called "variants" in the United States and a highly virulent strain known as "very virulent" or vvIBDV identified in Europe...
August 8, 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/30046320/rapid-detection-of-infectious-bursal-disease-by-loop-mediated-isothermal-amplification-for-field-analysis
#9
R S A Khan, W Ali, S Kiran, M S D Shah, Z A Tahir, M Habib
Infectious bursal disease (IBD) is an immunosuppressive, acute and highly contagious illness of growing-poultry stock infected with infectious bursal disease virus (IBDV). It is common in Pakistan, causing potential economic losses throughout the year. The objective of the study is to propose a rapid, sensitive and specific diagnostic tool, and compare it with existing commonly used reverse transcriptase polymerase chain reaction (RT-PCR) method for IBDV. Different primers were used for RT-PCR and reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) to target the IBD virus...
2018: Iranian Journal of Veterinary Research
https://www.readbyqxmd.com/read/30035612/circulation-of-very-virulent-avian-infectious-bursal-disease-virus-in-finland
#10
Niina Tammiranta, Christine Ek-Kommonen, Laila Rossow, Anita Huovilainen
In the spring of 2014 infectious bursal disease (IBD) was confirmed in a Finnish layer flock exhibiting clinical signs and increased mortality. Organ and blood samples were sent for diagnosis to the Finnish Food Safety Authority Evira. IBD virus (IBDV) was detected in RT-PCR studies. Altogether hens from six layer farms associated with increased mortality (7-10%, worst case 30%) were diagnosed with IBD during 2014. Antibodies were also detected with IBD-ELISA tests in hens on two farms. Phylogenetic analysis showed that the causative agent of the 2014 IBD outbreak was a non-reassortant very virulent type IBDV...
October 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/30021893/the-rna-binding-protein-of-a-double-stranded-rna-virus-acts-like-a-scaffold-protein
#11
Carlos P Mata, Johann Mertens, Juan Fontana, Daniel Luque, Carolina Allende-Ballestero, David Reguera, Benes L Trus, Alasdair C Steven, José L Carrascosa, José R Castón
Infectious bursal disease virus (IBDV), a non-enveloped, double-stranded (ds)RNA virus with a T=13 icosahedral capsid, has a virion assembly strategy that initiates with a precursor particle based on an internal scaffold shell similar to that of tailed dsDNA viruses. In IBDV-infected cells, the assembly pathway results mainly in mature virions that package four dsRNA segments, although minor viral populations ranging from zero to three dsRNA segments also form. We used cryo-electron microscopy, cryo-electron tomography and atomic force microscopy to characterize these IBDV populations...
July 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29981711/gga-mir-142-5p-attenuates-irf7-signaling-and-promotes-replication-of-ibdv-by-directly-targeting-the-chmda5-s-3-untranslated-region
#12
Wei Ouyang, Jing Qian, Qun-Xing Pan, Jing-Yu Wang, Xing-Xia Xia, Xiao-Li Wang, Yu-Mei Zhu, Yong-Shan Wang
Chicken melanoma differentiation-associated gene 5 (chMDA5) is a key pattern recognition receptor (PRR) that recognizes RNA viral infections and initiates an antiviral innate immune response in chickens. MicroRNAs (miRNAs) are involved in the regulation of chMDA5 to sense RNA virus infection, but how it exerts antiviral activity against infectious bursal disease virus (IBDV) infection and regulates chMDA5 in chicken cells is unclear. Thus, we measured the expression of chMDA5 in IBDV-infected DT40 cells and found it significantly increased...
July 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29979632/stau1-binds-to-ibdv-genomic-double-stranded-rna-and-promotes-viral-replication-via-attenuation-of-mda5-dependent-%C3%AE-interferon-induction
#13
Chengjin Ye, Zhaoli Yu, Yiwei Xiong, Yu Wang, Yina Ruan, Yueping Guo, Mianmian Chen, Shilu Luan, Enli Zhang, Hebin Liu
Infectious bursal disease virus (IBDV) infection triggers the induction of type I IFN, which is mediated by melanoma differentiation-associated protein 5 recognition of the viral genomic double-stranded RNA (dsRNA). However, the mechanism of IBDV overcoming the type I IFN antiviral response remains poorly characterized. Here, we show that IBDV genomic dsRNA selectively binds to the host cellular RNA binding protein Staufen1 (STAU1) in vitro and in vivo. The viral dsRNA binding region was mapped to the N-terminal moiety of STAU1 (residues 1-468)...
July 6, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29944399/genetic-characterization-of-infectious-bursal-disease-viruses-from-field-outbreaks-of-the-north-east-region-of-india
#14
Tridib Kumar Rajkhowa, Catherine Vanlalruati, Rahul S Arya
In recent years, acute severe outbreaks of infectious bursal disease (IBD) are frequently observed in commercial chicken populations of the North East Region (NER) of India, resulting in huge economic loses to poultry farmers. Field outbreaks of IBD in 30 different poultry farms in the NER were confirmed by clinicopathologic examination and reverse transcriptase PCR. A total of 10 isolates of IBD virus (IBDV) from these outbreaks were characterized by the genetic analysis of VP1 and the hypervariable region of the VP2 gene...
June 2018: Avian Diseases
https://www.readbyqxmd.com/read/29886054/differential-activation-of-intraepithelial-lymphocyte-natural-killer-cells-in-chickens-infected-with-very-virulent-and-vaccine-strains-of-infectious-bursal-disease-virus
#15
Mohammad Zareian Jahromi, Muhammad Bashir Bello, Mostafa Abdolmaleki, Swee Keong Yeap, Mohd Hair-Bejo, Abdul Rahman Omar
To gain insights into the role of CD3- /28.4+ intraepithelial lymphocytes-natural killer (CD3- /28.4+ IEL-NK) cells during infectious bursal disease virus (IBDV) infection, characterisation of the cells was performed following infection with different strains of the virus. In vitro treatment with IL-18 or ionomycin/PMA successfully stimulated and activated the cells via a significant increase in the expression of CD69, B-Lec, CHIR-AB1 and NK-lysin. Similarly, chickens infected with the vaccine strain of IBDV also up-regulated the expression of CD69, B-Lec, CHIR-AB1 and NK-lysin in CD3- /28...
October 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29872549/-gallid-herpesvirus-3-sb-1-strain-as-a-recombinant-viral-vector-for-poultry-vaccination
#16
Yashar Sadigh, Claire Powers, Simon Spiro, Miriam Pedrera, Andrew Broadbent, Venugopal Nair
Live herpesvirus-vectored vaccines are widely used in veterinary medicine to protect against many infectious diseases. In poultry, three strains of herpesvirus vaccines are used against Marek's disease (MD). However, of these, only the herpesvirus of turkeys (HVT) has been successfully developed and used as a recombinant vaccine vector to induce protection against other avian viral diseases such as infectious bursal disease (IBD), Newcastle disease (ND) or avian influenza (AI). Although effective when administered individually, recombinant HVT vectors have limitations when combined in multivalent vaccines...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/29778195/antigenicity-characterization-of-four-representative-natural-reassortment-ibdvs-isolated-from-commercial-three-yellow-chickens-from-southern-china-reveals-different-subtypes-co-prevalent-in-the-field
#17
Guo Chen, Xiumiao He, Lin Yang, Ping Wei
The antigenic relationships between the natural reassortment field strains of infectious bursal disease virus (IBDV), and between the field strains and the vaccine strains are poorly understood. In the present study, the antigenicity of four representative natural reassortment IBDV isolates designated JS7, GD10111, NN1005 and NN1172 from southern China during the years 2005-2011 and their antigenic relationship with the most commonly used vaccine strain B87 were investigated in vivo. For this purpose, cross-challenge studies were performed on 28-day-old birds, which were 2 weeks post-vaccination by oil-emulsion vaccines (OEVs) prepared from the four field viruses and B87, respectively...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29777734/gga-mir-454-suppresses-infectious-bursal-disease-virus-ibdv-replication-via-directly-targeting-ibdv-genomic-segment-b-and-cellular-suppressors-of-cytokine-signaling-6-socs6
#18
Mengjiao Fu, Bin Wang, Xiang Chen, Zhiyuan He, Yongqiang Wang, Xiaoqi Li, Hong Cao, Shijun J Zheng
MicroRNAs (miRNAs), as post-transcriptional regulators, play important roles in the process of viral infection through inhibiting virus replication or modulating host immune response. However, the role of miRNAs in host response against infectious bursal disease virus (IBDV) infection is still unclear. In this study, we found that gga-miR-454 of the host was decreased in response to IBDV infection and that transfection of DF-1 cells with miR-454 inhibited IBDV replication via directly targeting the specific sequence of IBDV genomic segment B, while blockage of endogenous miR-454 by inhibitors enhanced virus replication...
July 2, 2018: Virus Research
https://www.readbyqxmd.com/read/29691850/tissue-distribution-shedding-and-environmental-detection-of-infectious-bursal-disease-virus-genome-following-infection-of-meat-chickens-at-two-ages
#19
Jmkgk Jayasundara, S W Walkden-Brown, Afmf Islam, M E Katz, K G Renz
OBJECTIVE: To compare the effects of infectious bursal disease virus (IBDV) infection of commercial meat chickens at 0 and 16 days old (d.o.) and determine if IBDV vRNA is quantifiable in litter and dust samples. METHODS: Ross meat chickens (n = 60) were orally infected or not with IBDV at 0 or 16 d.o. Blood and faecal samples were collected longitudinally to 28 days post infection (dpi) from six chickens and tissues collected weekly from three euthanased chickens...
May 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29660049/ginsenoside-rg1-enhanced-immune-responses-to-infectious-bursal-disease-vaccine-in-chickens-with-oxidative-stress-induced-by-cyclophosphamide
#20
S Bi, X Chi, Y Zhang, X Ma, S Liang, Y Wang, S H Hu
This study was designed to evaluate the effect of oral administration of ginsenoside Rg1 on oxidative stress induced by cyclophosphamide in chickens. Ninety-six chickens were randomly divided into 4 groups, each consisting of 24 birds. Groups 2 and 3 received intramuscular injection of cyclophosphamide at 100 mg/kg body weight for 3 d to induce oxidative stress and immune suppression. Groups 1 and 4 were injected with saline in the same way as groups 2 and 3. Then chickens in group 3 were orally administrated Rg1 of 1 mg/kg body weight in drinking water for 7 d...
August 1, 2018: Poultry Science
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