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Infectious bursal disease virus

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https://www.readbyqxmd.com/read/29886054/differential-activation-of-intraepithelial-lymphocyte-natural-killer-cells-in-chickens-infected-with-very-virulent-and-vaccine-strains-of-infectious-bursal-disease-virus
#1
Mohammad Zareian Jahromi, Muhammad Bashir Bello, Mostafa Abdolmaleki, Swee Keong Yeap, Mohd Hair-Bejo, Abdul Rahman Omar
To gain insights into the role of CD3- /28.4+ intraepithelial lymphocytes-natural killer (CD3- /28.4+ IEL-NK) cells during infectious bursal disease virus (IBDV) infection, characterization of the cells was performed following infection with different strains of the virus. In vitro treatment with IL-18 or ionomycin/PMA successfully stimulated and activated the cells via a significant increase in the expression of CD69, B-Lec, CHIR-AB1 and NK-lysin. Similarly, chickens infected with the vaccine strain of IBDV also up-regulated the expression of CD69, B-Lec, CHIR-AB1 and NK-lysin in CD3- /28...
June 7, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29872549/-gallid-herpesvirus-3-sb-1-strain-as-a-recombinant-viral-vector-for-poultry-vaccination
#2
Yashar Sadigh, Claire Powers, Simon Spiro, Miriam Pedrera, Andrew Broadbent, Venugopal Nair
Live herpesvirus-vectored vaccines are widely used in veterinary medicine to protect against many infectious diseases. In poultry, three strains of herpesvirus vaccines are used against Marek's disease (MD). However, of these, only the herpesvirus of turkeys (HVT) has been successfully developed and used as a recombinant vaccine vector to induce protection against other avian viral diseases such as infectious bursal disease (IBD), Newcastle disease (ND) or avian influenza (AI). Although effective when administered individually, recombinant HVT vectors have limitations when combined in multivalent vaccines...
2018: NPJ vaccines
https://www.readbyqxmd.com/read/29778195/antigenicity-characterization-of-four-representative-natural-reassortment-ibdvs-isolated-from-commercial-three-yellow-chickens-from-southern-china-reveals-different-subtypes-co-prevalent-in-the-field
#3
Guo Chen, Xiumiao He, Lin Yang, Ping Wei
The antigenic relationships between the natural reassortment field strains of infectious bursal disease virus (IBDV), and between the field strains and the vaccine strains are poorly understood. In the present study, the antigenicity of four representative natural reassortment IBDV isolates designated JS7, GD10111, NN1005 and NN1172 from southern China during the years 2005-2011 and their antigenic relationship with the most commonly used vaccine strain B87 were investigated in vivo. For this purpose, cross-challenge studies were performed on 28-day-old birds, which were 2 weeks post-vaccination by oil-emulsion vaccines (OEVs) prepared from the four field viruses and B87, respectively...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29777734/gga-mir-454-suppresses-infectious-bursal-disease-virus-ibdv-replication-via-directly-targeting-ibdv-genomic-segment-b-and-cellular-suppressors-of-cytokine-signaling-6-socs6
#4
Mengjiao Fu, Bin Wang, Xiang Chen, Zhiyuan He, Yongqiang Wang, Xiaoqi Li, Hong Cao, Shijun J Zheng
MicroRNAs (miRNAs), as post-transcriptional regulators, play important roles in the process of viral infection through inhibiting virus replication or modulating host immune response. However, the role of miRNAs in host response against infectious bursal disease virus (IBDV) infection is still unclear. In this study, we found that gga-miR-454 of the host was decreased in response to IBDV infection and that transfection of DF-1 cells with miR-454 inhibited IBDV replication via directly targeting the specific sequence of IBDV genomic segment B, while blockage of endogenous miR-454 by inhibitors enhanced virus replication...
May 16, 2018: Virus Research
https://www.readbyqxmd.com/read/29691850/tissue-distribution-shedding-and-environmental-detection-of-infectious-bursal-disease-virus-genome-following-infection-of-meat-chickens-at-two-ages
#5
Jmkgk Jayasundara, S W Walkden-Brown, Afmf Islam, M E Katz, K G Renz
OBJECTIVE: To compare the effects of infectious bursal disease virus (IBDV) infection of commercial meat chickens at 0 and 16 days old (d.o.) and determine if IBDV vRNA is quantifiable in litter and dust samples. METHODS: Ross meat chickens (n = 60) were orally infected or not with IBDV at 0 or 16 d.o. Blood and faecal samples were collected longitudinally to 28 days post infection (dpi) from six chickens and tissues collected weekly from three euthanased chickens...
May 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29660049/ginsenoside-rg1-enhanced-immune-responses-to-infectious-bursal-disease-vaccine-in-chickens-with-oxidative-stress-induced-by-cyclophosphamide
#6
S Bi, X Chi, Y Zhang, X Ma, S Liang, Y Wang, S H Hu
This study was designed to evaluate the effect of oral administration of ginsenoside Rg1 on oxidative stress induced by cyclophosphamide in chickens. Ninety-six chickens were randomly divided into 4 groups, each consisting of 24 birds. Groups 2 and 3 received intramuscular injection of cyclophosphamide at 100 mg/kg body weight for 3 d to induce oxidative stress and immune suppression. Groups 1 and 4 were injected with saline in the same way as groups 2 and 3. Then chickens in group 3 were orally administrated Rg1 of 1 mg/kg body weight in drinking water for 7 d...
April 5, 2018: Poultry Science
https://www.readbyqxmd.com/read/29626271/bursal-immunopathology-responses-of-specific-pathogen-free-chickens-and-red-jungle-fowl-infected-with-very-virulent-infectious-bursal-disease-virus
#7
Mohd Isa Farhanah, Abdul Rahaman Yasmin, Nguyen Phuc Khanh, Swee Keong Yeap, Mohd Hair-Bejo, Abdul Rahman Omar
Very virulent infectious bursal disease virus (vvIBDV) targets B lymphocytes in the bursa of Fabricius (BF), causing immunosuppression and increased mortality rates in young birds. There have been few studies on the host immune response following vvIBDV infection at different inoculum doses in chickens with different genetic backgrounds. In this study, we characterized the immune responses of specific-pathogen-free (SPF) chickens and Malaysian red jungle fowl following infection with vvIBDV strain UPM0081 at 103...
April 6, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29620467/the-effect-of-infectious-bursal-disease-virus-induced-immunosuppression-on-vaccination-against-highly-pathogenic-avian-influenza-virus
#8
Erica Spackman, Christopher B Stephens, Mary J Pantin-Jackwood
Poor efficacy of avian influenza virus (AIV) vaccines in chickens has been documented in the field in spite of good results in experimental settings. Although the causes are multifactorial and complex, one contributing factor may be prior infection with immunosuppressive viruses. In an effort to evaluate the role of immunosuppressive agents on AIV pathogenesis and vaccine efficacy, the effect of prior infection with infectious bursal disease virus (IBDV), a ubiquitous immunosuppressive virus of chickens, was evaluated...
March 2018: Avian Diseases
https://www.readbyqxmd.com/read/29610580/infectious-bursal-disease-virus-inoculation-infection-modifies-campylobacter-jejuni-host-interaction-in-broilers
#9
Li Li, Colin Pielsticker, Zifeng Han, Tereza Kubasová, Ivan Rychlik, Bernd Kaspers, Silke Rautenschlein
Background: Campylobacter jejuni is considered as a chicken commensal. The gut microbiota and the immune status of the host may affect its colonization. Infectious bursal disease virus (IBDV) is an immunosuppressive virus of chickens, which allows secondary pathogens to invade or exacerbates their pathogenesis. To investigate the effect of IBDV-induced immunosuppression on the pathogenesis of C. jejuni , broiler chickens were inoculated with a very virulent (vv) strain of IBDV at 14 days post hatch followed by C...
2018: Gut Pathogens
https://www.readbyqxmd.com/read/29567034/squalene-containing-solid-lipid-nanoparticles-a-promising-adjuvant-system-for-yeast-vaccines
#10
Johannes J Stelzner, Martina Behrens, Sven-Erik Behrens, Karsten Mäder
Potent adjuvant systems are required for subunit and single antigen based vaccines to provide sufficient immunogenicity. Furthermore, adjuvants can reduce the required number of immunisations and the antigen amount. Squalene nanoemulsions, like MF59® and AddaVax™, are potent, safe and well characterised adjuvant systems and approved for use in humans. Here, we developed squalene containing solid lipid nanoparticles, which can be sterilised by steam sterilisation and stored as freeze-dried power together with a yeast-based vaccine...
April 19, 2018: Vaccine
https://www.readbyqxmd.com/read/29564226/gga-mir-155-enhances-type-i-interferon-expression-and-suppresses-infectious-burse-disease-virus-replication-via-targeting-socs1-and-tank
#11
Bin Wang, Mengjiao Fu, Yanan Liu, Yongqiang Wang, Xiaoqi Li, Hong Cao, Shijun J Zheng
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). MicroRNAs (miRNAs) are involved in host-pathogen interactions and innate immune response to viral infection. However, the role of miRNAs in host response to IBDV infection is not clear. We report here that gga-miR-155 acts as an anti-virus host factor inhibiting IBDV replication. We found that transfection of DF-1 cells with gga-miR-155 suppressed IBDV replication, while blockage of the endogenous gga-miR-155 by inhibitors enhanced IBDV replication...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29540633/virucidal-activity-of-a-quaternary-ammonium-compound-associated-with-calcium-hydroxide-on-avian-influenza-virus-newcastle-disease-virus-and-infectious-bursal-disease-virus
#12
Mariko Ito, Md Shahin Alam, Mayuko Suzuki, Satoru Takahashi, Miyuki Komura, Natthanan Sangsriratakul, Dany Shoham, Kazuaki Takehara
A quaternary ammonium compound (QAC) was evaluated for its virucidal efficacies with food additive grade calcium hydroxide (FdCa(OH)2 ). When the QAC was diluted 1:500 (QACx500) with redistilled water (dW2 ), it inactivated avian influenza virus (AIV) within 30 sec at 25°C, while at 2°C, it required 1 hr for inactivation. When FdCa(OH)2 powder was added to QACx500 at a final concentration of 0.17%, the mixture, namely Mix500, inactivated AIV within 3 min at 2°C. After contamination with 1% fetal bovine serum (FBS), Mix500 inactivated AIV within 2 hr at 2°C, but QACx500 did not...
April 18, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29540594/exacerbated-apoptosis-of-cells-infected-with-infectious-bursal-disease-virus-upon-exposure-to-interferon-alpha
#13
Liliana L Cubas-Gaona, Elisabet Diaz-Beneitez, Marina Ciscar, José F Rodríguez, Dolores Rodríguez
Infectious bursal disease virus (IBDV) belongs to the Birnaviridae family and is the etiological agent of a highly contagious and immunosuppressive disease (IBD) that affects domestic chickens ( Gallus gallus ). IBD or Gumboro disease leads to high rates of morbidity and mortality of infected animals and is responsible for major economic losses to the poultry industry worldwide. IBD is characterized by a massive loss of IgM-bearing B lymphocytes and the destruction of the bursa of Fabricius. The molecular bases of IBDV pathogenicity are still poorly understood; nonetheless, an exacerbated cytokine immune response and B cell depletion due to apoptosis are considered main factors that contribute to the severity of the disease...
June 1, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29540593/-infectious-bursal-disease-virus-hijacks-endosomal-membranes-as-the-scaffolding-structure-for-viral-replication
#14
María Cecilia Gimenez, Flavia Adriana Zanetti, Mauricio R Terebiznik, María Isabel Colombo, Laura Ruth Delgui
Birnaviruses are unconventional members of the double-stranded RNA (dsRNA) viruses group that are characterized by the lack of a transcriptionally active inner core. Instead, the birnaviral particles organize their genome in ribonucleoprotein complexes (RNPs) composed by dsRNA segments, the dsRNA-binding VP3 protein, and the viral encoded RNA-dependent RNA-polymerase (RdRp). This and other structural features suggests that birnaviruses may follow a completely different replication program from that followed by members of the Reoviridae family, supporting the hypothesis that birnaviruses are the evolutionary link between single-stranded positive RNA (+ssRNA) and dsRNA viruses...
March 14, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29521107/sequence-analysis-of-vp2-hypervariable-region-of-the-field-isolates-of-infectious-bursal-disease-viruses-from-southern-region-of-india
#15
P Raja, T M A Senthilkumar, C V Priyadarshini, M Parthiban, A Thangavelu, A Mangala Gowri, A Palanisammi, K Kumanan
Infectious bursal disease virus isolates obtained from southern parts of India were subjected to comparative sequencing and phylogenetic analysis of 743bp hypervariable region of VP2. The sequence analysis showed that among eight isolates, only HY12 showed the characteristic conserved amino acid residues at 256I, 294I, and 299S of vvIBDV. Six isolates BGE14, PY12, NKL14, VCN14, RPM14 and EDE14 had conserved amino acid residues at 256I and 299S, whereas at residue 294, isoleucine was substituted by valine. The remaining isolate MB11 had leucine at residue 294 and asparagine at residue 299 similar to classical strain 52/70...
2018: Acta Virologica
https://www.readbyqxmd.com/read/29517272/characterization-of-field-infectious-bursal-disease-viruses-in-zambia-evidence-of-co-circulation-of-multiple-genotypes-with-predominance-of-very-virulent-strains
#16
Racheal Mwenda, Katendi Changula, Bernard M Hang'ombe, Nozyechi Chidumayo, Alfred S Mangani, Titus Kaira, Ayato Takada, Aaron S Mweene, Edgar Simulundu
Infectious bursal disease (IBD) is a highly contagious, immunosuppressive disease of chickens and causes substantial economic losses to the poultry industry globally. This study investigated the genetic characteristics and pathological lesions induced by IBD viruses (IBDVs) that were associated with 60 suspected outbreaks in chickens during 2015-2016 in Lusaka Province, Zambia. Nucleotide sequences of VP2 hypervariable region (VP2-HVR) (n = 38) and part of VP1 (n = 37) of Zambian IBDVs were phylogenetically analysed...
June 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29476761/loop-mediated-isothermal-amplification-assay-for-detection-of-four-immunosuppressive-viruses-in-chicken
#17
HyeSoon Song, YouChan Bae, SeokChan Park, HyukMan Kwon, HeeSoo Lee, SeongJoon Joh
Loop-mediated isothermal amplification (LAMP) methods to detect chicken infectious anemia virus (CIAV), reticuloendotheliosis virus (REV), and Marek's disease virus (MDV), and a reverse transcription (RT)-LAMP assay to detect infectious bursal disease virus (IBDV), were developed. The CIAV-LAMP, REV-LAMP, MDV-LAMP, and IBDV-RT-LAMP methods were performed using four sets of six primers targeting the VP1 gene of CIAV, the gp90 gene of REV, the Meq gene of MDV, and the VP2 gene of IBDV. The results (a change in color) were observed visually...
June 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29427596/structural-and-functional-modeling-of-viral-protein-5-of-infectious-bursal-disease-virus
#18
Bhaskar Ganguly, Sunil Kumar Rastogi
Infectious Bursal Disease (IBD) is an acute, highly contagious and immunosuppressive disease of young chicken. The causative virus (IBDV) is a bi-segmented, double-stranded RNA virus. The virus encodes five major proteins, viral protein (VP) 1-5. VPs 1-3 have been characterized crystallographically. Albeit a rise in the number of studies reporting successful heterologous expression of VP5 in recent times, challenging the notion that rapid death of host cells overexpressing VP5 disallows obtaining sufficiently pure preparations of the protein for crystallographic studies, the structure of VP5 remains unknown and its function controversial...
March 2, 2018: Virus Research
https://www.readbyqxmd.com/read/29409800/infectious-bursal-disease-virus-in-algeria-detection-of-highly-pathogenic-reassortant-viruses
#19
Mouna Abed, Sébastien Soubies, Céline Courtillon, François-Xavier Briand, Chantal Allée, Michel Amelot, Claire De Boisseson, Pierrick Lucas, Yannick Blanchard, Ali Belahouel, Redouane Kara, Abdelhalim Essalhi, Soraya Temim, Djamel Khelef, Nicolas Eterradossi
Infectious bursal disease (IBD) is an immunosuppressive viral disease, present worldwide, which causes mortality and immunosuppression in young chickens. The causative agent, the Avibirnavirus IBDV, is a non-enveloped virus whose genome consists of two segments (A and B) of double-stranded RNA. Different pathotypes of IBDV exist, ranging from attenuated vaccine strains to very virulent viruses (vvIBDV). In Algeria, despite the prophylactic measures implemented, cases of IBD are still often diagnosed clinically and the current molecular epidemiology of IBDV remains unknown...
June 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29391066/recombinant-chicken-interleukin-7-as-a-potent-adjuvant-increases-the-immunogenicity-and-protection-of-inactivated-infectious-bursal-disease-vaccine
#20
Dan Cui, Jianlou Zhang, Yuzhu Zuo, Shanshan Huo, Yonghong Zhang, Liyue Wang, Xiujin Li, Fei Zhong
Our previous work showed that a plasmid-based chicken interleukin-7 (chIL-7) gene expression vector possessed potent adjuvant activity for a VP2 DNA vaccine against chicken infectious bursal disease virus (IBDV). Whether recombinant chIL-7 prepared in procaryotic expression system has the adjuvant activity for inactivated IBDV vaccine remains unknown. Here, we prepared recombinant chIL-7 using an E. coli expression system and analyzed its adjuvant activity for the inactivated IBDV vaccine. The results show that the recombinant chIL-7 was successfully prepared in E...
February 1, 2018: Veterinary Research
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