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Trust but verify

Catia Contado, Roberto Argazzi, Vincenzo Amendola
Many advanced industrial and biomedical applications that use silver nanoparticles (AgNPs), require that particles are not only nano-sized, but also well dispersed, not aggregated and not agglomerated. This study presents two methods able to give rapidly sizes of monodispersed AgNPs suspensions in the dimensional range of 20-100nm. The first method, based on the application of Mie's theory, determines the particle sizes from the values of the surface plasmon resonance wavelength (SPRMAX), read from the optical absorption spectra, recorded between 190nm and 800nm...
October 13, 2016: Journal of Chromatography. A
By O J Storebø, M Zwi, C R Moreira-Maia, M Skoog, G Camilla, D Gillies, E Simonsen, C Gluud
No abstract text is available yet for this article.
September 2016: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
Christoph Haller
No abstract text is available yet for this article.
August 12, 2016: Journal of Thoracic and Cardiovascular Surgery
Ami Hale, Nanna Christiansen, Heather Calvert
AIM: To assess the time it takes for paediatric TTA and inpatient orders to be dispensed and sent to ward. This is to establish if the Trust is meeting an operational Key Performance Indicator (KPI). STANDARDS KPIS: ▸ 85% of urgent items (TTAs) dispensed within 1 hour.▸ 85% of non-urgent items (most inpatient orders) dispensed within 3 hrs. METHOD: To audit the time it takes for TTAs and inpatient orders to be screened, sent to dispensary, labelled, dispensed, checked, and leave dispensary...
September 2016: Archives of Disease in Childhood
Denis Fourches, Eugene Muratov, Alexander Tropsha
There is a growing public concern about the lack of reproducibility of experimental data published in peer-reviewed scientific literature. Herein, we review the most recent alerts regarding experimental data quality and discuss initiatives taken thus far to address this problem, especially in the area of chemical genomics. Going beyond just acknowledging the issue, we propose a chemical and biological data curation workflow that relies on existing cheminformatics approaches to flag, and when appropriate, correct possibly erroneous entries in large chemogenomics data sets...
July 25, 2016: Journal of Chemical Information and Modeling
T Banaschewski, M Gerlach, K Becker, M Holtmann, M Döpfner, M Romanos
OBJECTIVE: A recent Cochrane review published by O. J. Storebo and colleagues (2015) raised substantial doubts about the benefit from stimulant medication with methylphenidate in the treatment of childhood ADHD due to the overall poor quality of studies. The systematic review thus contradicts all previous reviews and meta-analyses. METHOD: We here detail various examples of errors, inconsistencies, and misinterpretations in the review which led to false results and inadequate conclusions...
2016: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
Rebekah Jayne McNaughton, Jean Adams, Janet Shucksmith
INTRODUCTION: Since the 1990 s strenuous attempts have been made to rebuild trust in childhood immunisations. This study aimed to understand if financial incentives (FI) or quasi-mandatory schemes (QMS), e.g. mandating immunisations for entry to universal services such as day care or school, might be acceptable interventions to increase immunisations uptake for preschool children. MATERIAL AND METHODS: Parents and carers of preschool children (n=91); health and other professionals (n=18); and those responsible for developing and commissioning immunisation services (n=6) took part in the study...
April 27, 2016: Vaccine
Maher A Ghamloush, Erik Garpestad
No abstract text is available yet for this article.
December 2015: Respiratory Care
Paul Wicks, Emil Chiauzzi
Mobile health apps are health and wellness programs available on mobile devices such as smartphones or tablets. In three systematic assessments published in BMC Medicine, Huckvale and colleagues demonstrate that widely available health apps meant to help patients calculate their appropriate insulin dosage, educate themselves about asthma, or perform other important functions are methodologically weak. Insulin dose calculators lacked user input validation and made inappropriate dose recommendations, with a lack of documentation throughout...
2015: BMC Medicine
Jodi Schafer
No abstract text is available yet for this article.
August 2015: Journal of the Michigan Dental Association
Pekka Ruotsalainen, Peter Pharow, Francoise Petersen
Modern personal portable health devices (PPDs) become increasingly part of a larger, inhomogeneous information system. Information collected by sensors are stored and processed in global clouds. Services are often free of charge, but at the same time service providers' business model is based on the disclosure of users' intimate health information. Health data processed in PPD networks is not regulated by health care specific legislation. In PPD networks, there is no guarantee that stakeholders share same ethical principles with the user...
2015: Studies in Health Technology and Informatics
Martin Dachsel, Eugenia Lee
Cardiovascular disease remains common and accounts for many deaths, but primary cardiovascular risk factors are consistently underdiagnosed in the UK. NHS health checks are being implemented nationally in the next five years, targeting those aged 40 to 74 years, and many primary care trusts have commissioned health checks to be carried out opportunistically as an outreach programme in public places to aid uptake and improve access. However, there is little published evidence on the effectiveness and subsequent follow-up rates in such a model...
July 2011: London Journal of Primary Care
Brigitte Michelsen, Ragnhild Fiane, Andreas P Diamantopoulos, Dag Magnar Soldal, Inger Johanne W Hansen, Tuulikki Sokka, Arthur Kavanaugh, Glenn Haugeberg
OBJECTIVE: The main objective of this study was to compare disease burden in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (ax-SpA). METHODS: In this cross-sectional study, all the RA (1093), PsA (365) and ax-SpA (333) patients who visited the out-patient clinic of the Hospital of Southern Norway Trust during the year 2013 were included; the RA patients all had a RA diagnosis verified by the treating rheumatologist, the PsA patients all fulfilled the ClASsification for Psoriatic ARthritis (CASPAR) criteria and the ax-SpA patients all fulfilled the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for ax-SpA...
2015: PloS One
Emily Peckham, Mei-See Man, Natasha Mitchell, Jinshuo Li, Taeko Becque, Sarah Knowles, Tim Bradshaw, Claire Planner, Steve Parrott, Susan Michie, Charles Shepherd, Simon Gilbody
BACKGROUND: There is a high prevalence of smoking among people who experience severe mental ill health (SMI). Helping people with disorders such as bipolar illness and schizophrenia to quit smoking would help improve their health, increase longevity and also reduce health inequalities. Around half of people with SMI who smoke express an interest in cutting down or quitting smoking. There is limited evidence that smoking cessation can be achieved for people with SMI. Those with SMI rarely access routine NHS smoking cessation services...
March 2015: Health Technology Assessment: HTA
James L Rutkowski
No abstract text is available yet for this article.
February 2015: Journal of Oral Implantology
Marc C Deller, Bernhard Rupp
X-ray crystallography provides the most accurate models of protein-ligand structures. These models serve as the foundation of many computational methods including structure prediction, molecular modelling, and structure-based drug design. The success of these computational methods ultimately depends on the quality of the underlying protein-ligand models. X-ray crystallography offers the unparalleled advantage of a clear mathematical formalism relating the experimental data to the protein-ligand model. In the case of X-ray crystallography, the primary experimental evidence is the electron density of the molecules forming the crystal...
September 2015: Journal of Computer-aided Molecular Design
Peggy Compton
No abstract text is available yet for this article.
December 2014: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Radosław Lenarczyk, Ewa Jędrzejczyk-Patej, Michał Mazurek, Mariola Szulik, Oskar Kowalski, Patrycja Pruszkowska, Adam Sokal, Beata Średniawa, Joanna Boidol, Jacek Kowalczyk, Tomasz Podolecki, Grzegorz Mencel, Zbigniew Kalarus
BACKGROUND: The prognostic impact of improvement in health-related quality of life (QoL) and its relation to response in cardiac resynchronization therapy (CRT) recipients remains unknown. AIM: To assess the correspondence between response to CRT and improvements in QoL and to verify if a change in QoL after pacing influences outcome in CRT patients. METHODS: Ninety-seven participants of the Triple-Site Versus Standard Cardiac Resynchronization Therapy Trial (TRUST CRT) randomized trial, in New York Heart Association class III-IV, QRS width ≥ 120 ms, left ventricular ejection fraction ≤ 35%, and significant mechanical dyssynchrony were included...
January 2015: Pacing and Clinical Electrophysiology: PACE
John T Morris, James L Mueller, Michael L Jones
INTRODUCTION: People with disabilities are generally more vulnerable during disasters and public emergencies than the general population. Physical, sensory and cognitive impairments may result in greater difficulty in receiving and understanding emergency alert information, and greater difficulty in taking appropriate action. The use of social media in the United States has grown considerably in recent years. This has generated increasing interest on the part of national, state and local jurisdictions in leveraging these channels to communicate public health and safety information...
August 2014: Western Journal of Emergency Medicine
Wendi L Johnson, Peggy C Giordano, Wendy D Manning, Monica A Longmore
Research on intimate partner violence (IPV) has evolved over the last decade with increasing interest in how IPV develops over adolescence and young adulthood. Studies examining patterns of IPV over time have generally focused on victimization with less attention to temporal shifts in perpetration. While it is generally assumed that IPV peaks during young adulthood, this has not been empirically verified and documented. Additionally, prior longitudinal analyses of IPV have focused on identifying trajectories and their accompanying risk factors, with less attention given to within-individual change in IPV experiences across and within relationships...
March 2015: Journal of Youth and Adolescence
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