keyword
https://read.qxmd.com/read/38324081/subclinical-central-hypothyroidism-in-patients-with-hypothalamic-pituitary-disease-does-it-exist
#21
REVIEW
Julio Abucham, Manoel Martins
Central hypothyroidism (CH) is characterized by decreased thyroid hormone production due to insufficient stimulation of an otherwise normal thyroid gland by TSH. In patients with established hypothalamic-pituitary disease, a low FT4 concentration is considered highly specific, although poorly sensitive, for the diagnosis of CH. That would be comparable to diagnosing primary hypothyroidism in patients at risk only when serum FT4 concentrations are below the reference range, missing all patients with subclinical primary hypothyroidism and preventing proper therapy in patients in which thyroxine replacement is clearly beneficial...
February 7, 2024: Reviews in Endocrine & Metabolic Disorders
https://read.qxmd.com/read/38311995/-differential-diagnosis-and-tactics-of-managing-a-patient-with-primary-hypophysitis-on-the-example-of-a-clinical-case
#22
JOURNAL ARTICLE
N N Katamadze, A A Tskaeva, E A Pigarova, L K Dzeranova, N V Tarbaeva
In recent years, there has been a significant increase in the prevalence of autoimmune endocrinopathies, which are known to affect various levels of the endocrine system, including the pituitary gland. Hypophysitis is a general term used to describe any form of sellar and suprasellar inflammation that leads to structural changes in the hypothalamic-pituitary region and manifests itself in varying degrees of hormonal deficiency of the anterior and posterior pituitary glands. To date, there is a primary form of hypophysitis, which occurs as a result of an autoimmune lesion directly to the pituitary gland, and a secondary form of hypophysitis, which occurs as a result of the presence of a systemic autoimmune disease...
January 24, 2024: Problemy E̊ndokrinologii
https://read.qxmd.com/read/38311763/clinical-application-of-combination-11-c-c-methionine-and-13-n-n-ammonia-pet-ct-in-recurrent-functional-pituitary-adenomas-with-negative-mri-or-18-f-f-fdg-pet-ct
#23
JOURNAL ARTICLE
Zongming Wang, Zize Feng, Dimin Zhu, Xin Wang, Jinping Chen, Yonghong Zhu, Haijun Wang
BACKGROUND: We assessed the value of positron emission tomography/computed tomography (PET/CT) with [13 N]N-ammonia ([13 N]N-NH3) and [11 C]C-methionine ([11 C]C-MET) for the evaluation and management of recurrent secreting pituitary adenoma, which could not be detected by magnetic resonance imaging (MRI) or fluorine-18 fluorodeoxyglucose ([18 F]F-FDG) PET. METHODS: Nine consecutive patients with biochemical and clinical evidence of active recurrent tumor not detected by MRI and [18 F]F-FDG PET were enrolled in this study...
February 5, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38298322/correction-of-in-patient-severe-hypernatremia-in-an-81-year-old-female-with-hypopituitarism
#24
Luke Henwood, Austin Vaughn, Ravish Narvel, Rahil Gour
Hypernatremia has been significantly associated with in-hospital mortality and discharge to long-term care facilities. The appropriate correction of electrolyte disturbances, especially sodium, is important to consider to prevent the addition of central nervous system disturbances, such as cerebral edema and eventual brain injury. The importance of maintaining a proper correction of hypernatremia has been well studied and used in clinical practice. Choosing to use a hypotonic solution is a key principle. It is of utmost importance to adjust the rate of correction based on the patient's symptoms, underlying etiology, and associated comorbidities...
January 2024: Curēus
https://read.qxmd.com/read/38298315/treatment-response-to-acute-total-ophthalmoplegia-in-primary-pituitary-lymphoma-a-case-report-and-review-of-the-literature
#25
Saygı Uygur, Derya Karataş, Gözde Arslan, Ahmet Dağtekin, Emel Avcı
Primary pituitary lymphoma (PPL) is an extremely rare localized lymphoma without systemic involvement. The most common clinical presentations of PPL are hypopituitarism, headaches, and ophthalmoplegia. Diagnosing PPL without a biopsy is almost impossible. There is no study that has specifically investigated and reviewed treatment responses to the ophthalmological symptoms of PPL patients. Herein, we present a 66-year-old female patient who had acute-onset total ophthalmoplegia and headache as admission symptoms, which was diagnosed as PPL after subtotal resection...
January 2024: Curēus
https://read.qxmd.com/read/38288223/when-a-low-t-diagnosis-can-be-the-clue-to-a-more-complex-problem
#26
Adrian G Dumitrascu, Ana-Maria Chindris, Claudiu Matei, Razvan M Chirila
Male hypogonadism remains a poorly evaluated and managed clinical condition despite the availability of clinical guidelines. We present a case of a male patient diagnosed with secondary hypogonadism related to partial empty sella syndrome, whose clinical course was complicated by a hypotensive near-syncopal event. Although initial hypopituitarism symptoms could be subtle and nonspecific and could involve only one hormonal axis, a thorough evaluation of the pituitary function may identify additional deficiencies such as a subclinical chronic adrenal insufficiency that may become manifest during situations of increased physiological stress with potential life-threatening consequences...
December 2023: Curēus
https://read.qxmd.com/read/38281757/secondary-vs-primary-pituitary-xanthogranulomas-which-yellow-is-more-mellow
#27
JOURNAL ARTICLE
Dragana Miljic, Sandra Pekic, Mirjana Doknic, Marko Stojanovic, Sasa Ilic, Marina Nikolic Djurovic, Zvezdana Jemuovic, Toplica Milojevic, Mihailo Milicevic, Marija Jovanovic, Milica Medic Stojanoska, Bojana Carić, Nevena Radic, Sanja Medenica, Emilija Manojlovic Gacic, Milan Petakov
Pituitary xanthogranulomatomas (XG) are a rare pathological entity caused by accumulation of lipid laden macrophages and reactive granuloma formation usually triggered by cystic fluid leakage or hemorrhage. Our aim was to compare clinical characteristics and presenting features of patients with secondary etiology of XG and those with no identifiable founding lesion (primary -"pure" XG) in order to gain new insights into this rare pituitary pathology. In a retrospective review of 714 patients operated for sellar masses, at tertiary center, we identified 16 (2...
January 27, 2024: Endocrine Journal
https://read.qxmd.com/read/38276973/pediatric-sellar-teratoma-case-report-and-review-of-the-literature
#28
JOURNAL ARTICLE
Katja Kürner, Ladina Greuter, Michel Roethlisberger, Yves Brand, Stephan Frank, Raphael Guzman, Jehuda Soleman
BACKGROUND: Intracranial teratoma represents a rare neoplasm, occurring predominantly during childhood. Characteristic symptoms depend on the location but are mainly hydrocephalus, visual disturbances, hypopituitarism, and diabetes insipidus. Initial diagnosis can be challenging due to similar radiological features in both teratomas and other lesions such as craniopharyngiomas. Gross total resection is recommended if feasible and associated with a good prognosis. CASE DESCRIPTION: A 10-year-old girl presented with newly diagnosed growth retardation, fatigue, cephalgia and bilateral hemianopia...
January 26, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38270844/special-features-on-insulin-resistance-metabolic-syndrome-and-vascular-complications-in-hypopituitary-patients
#29
REVIEW
Heraldo M Garmes
Pituitary hormone deficiency, hypopituitarism, is a dysfunction resulting from numerous etiologies, which can be complete or partial, and is therefore heterogeneous. This heterogeneity makes it difficult to interpret the results of scientific studies with these patients.Adequate treatment of etiologies and up-to-date hormone replacement have improved morbidity and mortality rates in patients with hypopituitarism. As GH replacement is not performed in a reasonable proportion of patients, especially in some countries, it is essential to understand the known consequences of GH replacement in each subgroup of patients with this heterogeneous dysfunction...
January 25, 2024: Reviews in Endocrine & Metabolic Disorders
https://read.qxmd.com/read/38270722/successful-treatment-of-medically-and-surgically-refractory-lymphocytic-hypophysitis-with-fractionated-stereotactic-radiotherapy-a-single-center-experience-and-systematic-literature-review
#30
JOURNAL ARTICLE
Mehdi Khaleghi, Guilherme Finger, Kyle C Wu, Vikas Munjal, Luma Ghalib, Peter Kobalka, Dukagjin Blakaj, Khaled Dibs, Ricardo Carrau, Daniel Prevedello
PURPOSE: To explore the potential role of focused radiotherapy in managing the lymphocytic hypophysitis (LH) refractory to medical therapy and surgery. METHOD: A systematic literature review was conducted following PRISMA guidelines to identify the studies on radiation treatment for hypophysitis, along with the experience in our institution. RESULTS: The study included eight patients, three from our institution and five from existing literature...
January 25, 2024: Pituitary
https://read.qxmd.com/read/38262374/cortisol-dynamics-quality-of-life-and-fatigue-following-traumatic-brain-injury-in-childhood
#31
JOURNAL ARTICLE
Nikolaos Daskas, Peta Sharples, Marcus Likeman, Stafford Lightman, Elizabeth Crowne
INTRODUCTION: Traumatic brain injury (TBI) is a leading cause of acquired neurological morbidity. The prevalence of post-traumatic hypopituitarism (PTHP) and associated morbidity after childhood TBI is unclear. Our study investigated long term HPA (hypothalamus-pituitary-adrenal) axis function, in a prospective childhood TBI and control cohort, using measures of cortisol/cortisone secretion (physiological, stimulated), HPA axis feedback and exploring associations with fatigue, depression and Quality of Life (QoL) outcomes...
January 23, 2024: Hormone Research in Pædiatrics
https://read.qxmd.com/read/38260089/explaining-long-covid-a-pioneer-cross-sectional-study-supporting-the-endocrine-hypothesis
#32
JOURNAL ARTICLE
Taieb Ach, Nassim Ben Haj Slama, Asma Gorchane, Asma Ben Abdelkrim, Meriem Garma, Nadia Ben Lasfar, Foued Bellazreg, Widéd Debbabi, Wissem Hachfi, Molka Chadli Chaieb, Monia Zaouali, Amel Letaief, Koussay Ach
CONTEXT: In some patients, symptoms may persist after COVID-19, defined as long COVID. Its pathogenesis is still debated and many hypotheses have been raised. OBJECTIVE: Our primary objective was to evaluate the corticotroph and somatotroph functions of patients previously infected with SARS-CoV-2 and experiencing post-COVID-19 syndrome to detect any deficiencies that may explain long COVID. METHODS: A cross-sectional study was conducted including patients who had previously contracted SARS-CoV-2 with a postinfection period of 3 months or less to 15 months, divided into 2 groups...
January 16, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38249203/an-orthodenticle-homeobox-2-otx2-mutation-in-a-patient-with-combined-pituitary-hormone-deficiency-pituitary-malformation-and-retinitis-pigmentosa
#33
Cátia Araújo, Carla Baptista, Isabel Paiva
Heterozygous mutations of orthodenticle homeobox 2 ( OTX2 )can result in ocular malformations, pituitary abnormalities, or hypopituitarism spanning from isolated growth hormone (GH) deficiency to combined pituitary hormone deficiency. We present a patient exhibiting growth and pubertal disturbances, developmental delay, and pigmentary retinopathy. Further examination revealed deficiencies in GH following clonidine stimulation, hypogonadism, and, subsequently, central hypothyroidism. Brain magnetic resonance imaging uncovered hypoplasia of the pituitary and an ectopic pituitary tissue...
December 2023: Curēus
https://read.qxmd.com/read/38246768/-multidisciplinary-efforts-to-improve-the-diagnosis-and-treatment-of-cirrhosis-due-to-anterior-pituitary-hypopituitarism
#34
JOURNAL ARTICLE
X Y Wu, J Y Zhang
More and more clinical evidence confirms that hypopituitary dysfunction can lead to liver cirrhosis. The causes of hypopituitary dysfunction include sellarneoplastic diseases, hereditary diseases, perinatal adverse events, etc. Clinically, growth hormone deficiency (GHD) often the first cause in hypopituitary dysfunction.Hypopituitary dysfunction, especially GHD, can lead to liver cirrhosis, which in turn can result in damage to multiple organs such as the secondary lungs, spleen, and heart.Therefore, its clinical manifestations are complex, and the patients are first diagnosed in various departments...
January 23, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38240912/androgen-deficiency-in-hypopituitary-women-its-consequences-and-management
#35
REVIEW
Daniela Esposito, Åsa Tivesten, Catharina Olivius, Oskar Ragnarsson, Gudmundur Johannsson
Women with hypopituitarism have various degrees of androgen deficiency, which is marked among those with combined hypogonadotrophic hypogonadism and secondary adrenal insufficiency. The consequences of androgen deficiency and the effects of androgen replacement therapy have not been fully elucidated. While an impact of androgen deficiency on outcomes such as bone mineral density, quality of life, and sexual function is plausible, the available evidence is limited. There is currently no consensus on the definition of androgen deficiency in women and it is still controversial whether androgen substitution should be used in women with hypopituitarism and coexisting androgen deficiency...
January 19, 2024: Reviews in Endocrine & Metabolic Disorders
https://read.qxmd.com/read/38224403/presentation-and-outcomes-of-paediatric-craniopharyngioma-in-the-west-of-scotland-a-25-year-experience
#36
JOURNAL ARTICLE
Xuan Ye Chanel Kuah, Angela K Lucas-Herald, Sarah McCarrison, Roisin Boyle, Claire Adey, Anthony Amato-Watkins, Parameswaran Bhattathiri, Emer Campbell, Fiona Cowie, Liam Dorris, Ben Fulton, Diana Mcintosh, Dermot Murphy, Milind Ronghe, Roddy O'Kane, Lorraine Todd, Meharpal Sangra, Jairam Sastry, Eoghan Millar, Samih Hassan, M Guftar Shaikh
PURPOSE: Craniopharyngiomas can be aggressive leading to significant complications and morbidity. It is not clear whether there are any predictive factors for incidence or outcomes. Our aim was therefore to record the incidence, presentation, characteristics and progression of paediatric craniopharyngiomas in the West of Scotland. METHOD: Retrospective case note review for children diagnosed with paediatric craniopharyngiomas at the Royal Hospital for Children Glasgow, from 1995 to 2021 was conducted...
January 15, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38222053/health-related-quality-of-life-of-pediatric-brain-tumor-survivors-after-treatment-in-jordan
#37
JOURNAL ARTICLE
Han Choi, Amr S Soliman, Randa Al Mousa, Jennifer Yeh, Jamal Khader, Iyad Sultan, Ahmad Kh Ibrahimi
BACKGROUND: The number of cancer survivors and survivorship are increasing. Health-related quality of life (HRQOL) has not been widely studied in low-and-middle-income countries (LMICs). The aim of this study is to explore HRQOL of childhood brain tumor survivors and its determinants in Jordan. METHODS: Health-related quality of life information was collected from 80 patients treated at the King Hussein Cancer Center and their parents using the Pediatric Quality of Life Inventory (PedsQL) Generic Core Scales questionnaire in Arabic...
February 2024: Neuro-oncology Practice
https://read.qxmd.com/read/38218060/hypothalamic-pituitary-dysfunction-after-nasopharyngeal-carcinoma-irradiation
#38
JOURNAL ARTICLE
Nadia Bouzid, Amal Chamsi, Ines Barka, Sarra Sghaier, Sabrine Tbessi, Koussay Elleuch, Sameh Tebra
PURPOSE: Radiotherapy (RT) is the corner stone of nasopharyngeal carcinoma (NPC) treatment but it exposes to late effects especially hypothalamic pituitary deficiency (HPD). In this article,we aimed to assess the impact of RT on pituitary function in NPC survivors. METHODS: We included 55 patients treated in the radiation oncology department, of Farhat Hached Hospital in Sousse, Tunisia. RESULTS: All patients received facio-cervical RT with a mean dose of 73...
December 22, 2023: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38200500/coverage-of-education-and-training-of-traumatic-brain-injury-induced-growth-hormone-deficiency-in-us-residency-and-fellowship-programs-a-cross-sectional-study
#39
JOURNAL ARTICLE
Javier Cárdenas, Nicky Kelepouris, Radhika Adiga, Kevin C J Yuen
BACKGROUND: Hypopituitarism, including growth hormone deficiency (GHD), is a common sequela of traumatic brain injury (TBI). This study explored the coverage of education and training of TBI-induced hypopituitarism in general and GHD in particular, in postgraduate program curricula to identify knowledge gaps and opportunities. METHODS: An online survey and qualitative interviews (focus groups) were conducted among endocrinology, neurology, and physiatry postgraduate program directors in the United States (US)...
January 10, 2024: BMC Medical Education
https://read.qxmd.com/read/38192652/hypopituitarism-induced-by-pembrolizumab-plus-axitinib-in-the-treatment-of-metastatic-renal-cell-carcinoma-a-case-report
#40
Kazushi Hanawa, Norifumi Sawada, Junki Aikawa, Yuko Otake, Yoshifumi Kasai, Keito Mochizuki, Hiroshi Shimura, Takanori Mochizuki, Satoru Kira, Takahiko Mitsui
Immune checkpoint inhibitor (ICI) therapies have broadened the armamentarium for metastatic renal cell carcinoma (mRCC). As the ICI therapy spreads in the clinical settings, immune-related adverse events are more of a concern for clinicians. The present study reports three cases of mRCC treated with pembrolizumab plus axitinib and diagnosed hypopituitarism based on clinical symptoms and hormonal profile. Acute methylprednisolone infusion therapy was necessary in one case because of severe adrenal hypofunction; however, the clinical symptoms of the other two cases were controlled with oral corticosteroid therapy...
February 2024: Oncology Letters
keyword
keyword
77095
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.