keyword
https://read.qxmd.com/read/38476426/factors-predicting-outcomes-of-endoscopic-endonasal-approach-in-craniopharyngioma-patients
#1
JOURNAL ARTICLE
Chin Taweesomboonyat, Raywat Noiphithak, Pree Nimmannitya, Sakchai Sae-Heng
OBJECTIVES: Endoscopic endonasal approach (EEA) is commonly used for resection of craniopharyngioma (CP). Treatment outcomes of EEA for CP were related to numerous factors; however, they have been evaluated in few studies. The objective of this study is to investigate factors associated with the outcomes of CP following this operation. MATERIALS AND METHODS: The records of patients with CP, who underwent EEA at our institution from January 2014 to June 2022, were retrospectively reviewed...
2024: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/38473913/hemochromatosis-ferroptosis-ros-gut-microbiome-and-clinical-challenges-with-alcohol-as-confounding-variable
#2
REVIEW
Rolf Teschke
Hemochromatosis represents clinically one of the most important genetic storage diseases of the liver caused by iron overload, which is to be differentiated from hepatic iron overload due to excessive iron release from erythrocytes in patients with genetic hemolytic disorders. This disorder is under recent mechanistic discussion regarding ferroptosis, reactive oxygen species (ROS), the gut microbiome, and alcohol abuse as a risk factor, which are all topics of this review article. Triggered by released intracellular free iron from ferritin via the autophagic process of ferritinophagy, ferroptosis is involved in hemochromatosis as a specific form of iron-dependent regulated cell death...
February 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38462513/hypopituitarism-due-to-cns-aspergillus-infection
#3
JOURNAL ARTICLE
Shogo Funakoshi, Mitsuru Nishiyama, Masahiro Komori, Masamitsu Hyodo, Yu Kawanishi, Tetsuya Ueba, Shimpei Fujimoto, Yoshio Terada
A 59-year-old man was admitted to our hospital with hyponatremia. An endocrine examination indicated panhypopituitarism, and magnetic resonance imaging revealed a mass-like lesion in the pituitary gland. Sinus endoscopy revealed a fungal mass in the sphenoid sinus, and the patient was diagnosed with hypopituitarism due to aspergillosis of the central nervous system (CNS). The patient's hyponatremia resolved with hydrocortisone replacement. Although the right internal carotid artery was eventually occluded, antifungal medications were administered for the aspergillosis, and the patient's general condition improved...
March 11, 2024: Internal Medicine
https://read.qxmd.com/read/38457091/fractionated-stereotactic-radiotherapy-in-craniopharyngiomas-a-systematic-review-and-single-arm-meta-analysis
#4
REVIEW
Lucca B Palavani, Guilherme Melo Silva, Pedro G L B Borges, Márcio Yuri Ferreira, Marcelo Porto Sousa, Marianna G H S J Leite, Leonardo de Barros Oliveira, Sávio Batista, Raphael Bertani, Allan Dias Polverini, André Beer-Furlan, Wellingson Paiva
INTRODUCTION: Numerous studies have demonstrated Fractionated Stereotactic Radiotherapy's (FSRT) effectiveness in tumor control post-resection for craniopharyngiomas. Nevertheless, past literature has presented conflicting findings particularly regarding endocrine and visual function outcomes. This study aims to elucidate FSRT's efficacy and safety for this population. METHODS: Adhering to PRISMA, a systematic review and meta-analyses was conducted. Included studies had to report the effects of FSRT for treating craniopharyngiomas in a sample greater than four patients, addressing at least one of the outcomes of interest: improvement in visual acuity or field, new-onset hypopituitarism, effectiveness, and tumor progression...
March 8, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38453980/the-deleterious-effects-of-sofosbuvir-and-ribavirin-antiviral-drugs-against-hepatitis-c-virus-on-different-body-systems-in-male-albino-rats-regarding-reproductive-hematological-biochemical-hepatic-and-renal-profiles-and-histopathological-changes
#5
JOURNAL ARTICLE
Rana A Ali, Eatemad A Awadalla, Yahia A Amin, Samer S Fouad, Maha Abd-El Baki Ahmed, Mohammed H Hassan, Emaad Abdel-Kahaar, Rehab H Abdel-Aziz
Sofosbuvir is one of the crucial drugs used in the treatment of chronic hepatitis C virus (HCV) in adults and children with compensated liver disease, including cirrhosis. It may be used alone or with other drugs. Ribavirin is an antiviral medication used to treat HCV infection. It is not effective when used alone and must be used in combination with other medications, such as sofosbuvir. This study pertains to a comprehensive assessment of the deleterious effects of sofosbuvir (an antiviral drug against chronic HCV) or sofosbuvir combined with ribavirin (an antiviral drug against RNA and DNA viruses) on several biological activities of the body, including hematological, hormonal, biochemical, histological, and immunohistochemical examinations during a long-standing period on male healthy rats...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38452869/position-statement-on-the-diagnosis-and-management-of-congenital-pituitary-deficiency-in-adults-the-french-national-diagnosis-and-treatment-protocol-ndtp
#6
JOURNAL ARTICLE
S Castets, F Albarel, A Bachelot, G Brun, J Bouligand, C Briet, E Bui Quoc, C Cazabat, C Chabbert-Buffet, S Christin-Maitre, C Courtillot, T Cuny, G De Filippo, B Donadille, F Illouz, I Pellegrini, Y Reznik, A Saveanu, N Teissier, P Touraine, M C Vantyghem, J Vergier, J Léger, T Brue, R Reynaud
Pituitary deficiency, or hypopituitarism, is a rare chronic disease. It is defined by insufficient synthesis of one or more pituitary hormones (growth hormone, TSH, ACTH, LH-FSH, prolactin), whether or not associated with arginine vasopressin deficiency (formerly known as diabetes insipidus). In adult patients, it is usually acquired (notably during childhood), but can also be congenital, due to abnormal pituitary development. The present study focuses on congenital pituitary deficiency in adults, from diagnosis to follow-up, including special situations such as pregnancy or the elderly...
March 5, 2024: Annales D'endocrinologie
https://read.qxmd.com/read/38451095/-one-and-a-half-interdural-transcavernous-pituitary-transposition-rotation-for-protection-of-hypophyseal-portal-system-in-adult-peripheral-retroinfundibular-craniopharyngioma
#7
JOURNAL ARTICLE
Ao Shen, Yang Yu, Liang Lyu, Shu Jiang, Dongjie Zhou, Jianguo Xu, Peizhi Zhou
BACKGROUND AND OBJECTIVES: Craniopharyngiomas originate from the pituitary stalk (PS) and extend along the pituitary-hypothalamic axis. Peripheral retroinfundibular craniopharyngiomas, particularly, may have worse surgery outcomes than other types. This study aims to investigate the advantage of using "one-and-a-half" interdural transcavernous pituitary transposition/rotation to dissect the tumor from the residual stalk and hypophyseal portal system for this subtype of craniopharyngioma...
March 7, 2024: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/38445135/a-case-report-of-sheehan-syndrome-a-rare-cause-of-hypopituitarism
#8
Ana Luís Vasconcelos, Rita Pinto Ribeiro, Patrícia Claúdio Ferreira, Joana Maciel, Rosário Araújo
Sheehan syndrome is a rare cause of hypopituitarism characterized by pituitary gland necrosis after postpartum hemorrhage. It is a pertinent cause of maternal morbidity and mortality in developing countries with deficient obstetrical care but is frequently overlooked in developed countries where its occurrence is uncommon. We present the case of a 66-year-old female diagnosed with Sheehan syndrome more than 30 years after her last delivery complicated by postpartum hemorrhage. Although the patient presented several symptoms and signs of pituitary hormonal deficiencies, a diagnosis had never been established before...
February 2024: Curēus
https://read.qxmd.com/read/38440488/endoscopic-endonasal-trans-sphenoidal-minimally-invasive-pituitary-surgery-with-image-guided-navigation-system-igns-learning-experience-of-ent-surgeon-first-author
#9
JOURNAL ARTICLE
Debasish Ghosh, Srikrishna Majhi, Ankit Choudhary, Saikat Samaddar, Abhijit Guha, Soutrik Kumar, Mainak Maitra, Arunabha Sengupta
UNLABELLED: Introduction- Endoscopic minimally invasive pituitary surgery (MIPS) is advantageous over microscopic technique, as it provides superior close up, wide angle view of surgical target area. Image guided navigation system (IGNS) guides the surgeon to localize the lesion. In the present study we analyzed the Image Guided Surgical procedure and outcome of Endoscopic minimally invasive pituitary surgery and shared our experiences regarding disease clearance. MATERIALS AND METHODS: During the period of April 2015 to August 2022 a total 104 patients, diagnosed with pituitary adenoma underwent surgery and further followed up in a multidisciplinary team approach in a tertiary care hospital of Kolkata, India...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38436926/differences-between-gh-and-prl-co-secreting-and-gh-secreting-pituitary-adenomas-a-series-of-604-cases
#10
JOURNAL ARTICLE
Marta Araujo-Castro, Betina Biagetti, Edelmiro Menéndez Torre, Iría Novoa-Testa, Fernando Cordido, Eider Pascual Corrales, Víctor Rodríguez Berrocal, Fernando Guerrero-Pérez, Almudena Vicente, Juan Carlos Percovich, Rogelio García Centeno, Laura González, María Dolores Ollero García, Ana Irigaray Echarri, María Dolores Moure Rodríguez, Cristina Novo-Rodríguez, María Calatayud, Rocío Villar, Ignacio Bernabéu, Cristina Alvarez-Escola, Pamela Benítez Valderrama, Carmen Tenorio-Jimenéz, Pablo Abellán Galiana, Eva Venegas Moreno, Inmaculada González Molero, Pedro Iglesias, Concepción Blanco, Fernando Vidal-Ostos De Lara, Paz de Miguel, Elena López Mezquita, Felicia Hanzu, Iban Aldecoa, Cristina Lamas, Silvia Aznar, Anna Aulinas, Anna Calabrese, Paola Gracia, José María Recio-Córdova, Mariola Aviles, Diego Asensio-Wandosel, Miguel Sampedro, Ignacio Ruz-Caracuel, Rosa Camara, Miguel Paja, Carmen Fajardo-Montañana, Mónica Marazuela, Manel Puig-Domingo
PURPOSE: To evaluate differences in clinical presentation and in surgical outcomes between growth hormone-secreting pituitary adenomas (GH-PAs) and GH and prolactin co-secreting pituitary adenomas (GH&PRL-PAs). METHODS: Multicenter retrospective study of 604 patients with acromegaly submitted to pituitary surgery. Patients were classified into two groups according to serum PRL levels at diagnosis and immunohistochemistry (IHC) for PRL: a) GH&PRL-PAs when PRL levels were above the upper limit of normal and IHC for GH and PRL was positive or PRL levels were >100ng/and PRL IHC was not available (n=130) and b) GH-PAs who did not meet the previously mentioned criteria (n=474)...
March 4, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38435165/a-case-report-of-hemolytic-hyponatremia
#11
Santiago Manrique-Castaño, Luisa Rodríguez-Rosero, Raúl Vallejo-Serna
Hereditary spherocytosis/elliptocytosis is a non-immune hemolytic anemia caused by an alteration in the erythrocyte membrane that predisposes the cell to its lysis. This report presents a case of a 42-year-old woman with a history of spontaneous abortion, associated with postpartum bleeding, chronic anemia, and premature menopause. After five years, she consulted due to alterations in the state of consciousness and severe symptomatic hyponatremia, with a diagnosis of hypopituitarism, explained by a late Sheehan syndrome...
February 2024: Curēus
https://read.qxmd.com/read/38430312/the-role-of-endoscopic-endonasal-salvage-surgery-in-recurrent-or-residual-craniopharyngioma-after-a-transcranial-approach-a-systematic-review
#12
JOURNAL ARTICLE
Gurkirat Kohli, Phabinly J Gabriel, Melanie Brady, Christina H Fang, Jean Anderson Eloy, James K Liu
BACKGROUND: The management of craniopharyngiomas is challenging due to their high rate of recurrence following resection. Excision of recurrent tumors poses further surgical challenges due to loss of arachnoidal planes and adherence to anatomical structures. The endoscopic endonasal approach (EEA) offers a favorable alternative to transcranial approaches for primary craniopharyngiomas. However, the safety and efficacy of EEA for recurrent tumors, specifically after a prior transcranial approach, needs further investigation...
March 2, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38421589/reversibility-of-disturbed-pituitary-function-in-pediatric-conditions-with-psychological-stressors-implications-for-clinical-practice
#13
REVIEW
Aristeidis Giannakopoulos, Dionisios Chrysis
The complex communication network between the central nervous system and the hypothalamic-pituitary axis forms the basis of endocrine functional plasticity, which facilitates adaptation to changing internal and external conditions, but also makes it vulnerable to the negative effects of stressful psychological factors. Herein, clinical conditions such as functional hypothalamic amenorrhea, eating disorders, growth faltering, post-traumatic stress disorder, and pubertal disorders that may emerge during childhood or adolescence, their origin possibly including psychological stressors, are analyzed regarding their genetic susceptibility and reversibility of endocrine function...
February 29, 2024: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38409422/multi-omics-investigations-in-endocrine-systems-and-their-clinical-implications
#14
JOURNAL ARTICLE
Rodrigo Antonio Peliciari-Garcia, Carolina Fonseca de Barros, Ayla Secio-Silva, Diogo de Barros Peruchetti, Renata Marino Romano, Paula Bargi-Souza
Innovative techniques such as the "omics" can be a powerful tool for the understanding of intracellular pathways involved in homeostasis maintenance and identification of new potential therapeutic targets against endocrine-metabolic disorders. Over the last decades, proteomics has been extensively applied in the study of a wide variety of human diseases, including those involving the endocrine system. Among the most endocrine-related disorders investigated by proteomics in humans are diabetes mellitus and thyroid, pituitary, and reproductive system disorders...
2024: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/38374867/quality-of-life-and-hormonal-impairment-in-pediatric-patients-with-craniopharyngiomas
#15
JOURNAL ARTICLE
Bárbara Pereira Neto, Ines Pais Cunha, Ana Laura Leite-Almeida, Sofia Ferreira, Janine Coelho, Rita Lago, Josué Pereira, Maria João Gil-da-Costa, Paulo Almeida, Cintia Castro-Correia
INTRODUCTION: Craniopharyngiomas (CP) are tumors in the sellar region that, despite a high survival rate, are associated with significant morbidity, including hypothalamic, hormonal, and visual dysfunction. This study aimed to assess the quality of life (QoL) in pediatric patients with CP and to evaluate its relationship with various factors, with a focus on the impact of endocrine dysfunction. METHODS: In this observational cross-sectional study, patients with CP aged between 0 and 18 years, currently followed up in a tertiary hospital by a multidisciplinary team, were included...
January 2024: Curēus
https://read.qxmd.com/read/38344342/delayed-sheehan-s-syndrome-diagnosed-during-the-evaluation-of-secondary-infertility-a-case-report
#16
Surbhi Saxena, Vishesh Verma, Samir Samadarshi, Thinley Dorji, Jayaraman Muthukrishnan
Sheehan's syndrome may present with postpartum lactation failure and amenorrhea or with features of isolated hypopituitarism to panhypopituitarism. A high index of suspicion is required in a relevant clinical setting of postpartum hemorrhage.
February 2024: Clinical Case Reports
https://read.qxmd.com/read/38326790/unique-case-of-lymphocytic-hypophysitis-with-normal-pituitary-hormone-serology-mimicking-a-non-functioning-pituitary-adenoma
#17
JOURNAL ARTICLE
Kyle Shen, Catherine Cadang, Daniel Phillips, Varsha Babu
BACKGROUND: Lymphocytic hypophysitis is a rare autoimmune condition that usually presents during pregnancy and causes inflammation of the pituitary gland. Although the pathophysiology is not well understood, it often presents with headaches, visual disturbances, and symptoms of hypopituitarism. However, not all cases may present with hypopituitarism which can make this rare disease with an incidence of ~ 1 in 9 million much more difficult to diagnose. CASE PRESENTATION: We present a 35-year-old G4P4 woman with progressive vision loss and intermittent frontal headaches during her first trimester through 2 months postpartum...
February 8, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38326058/-effect-of-growth-hormone-supplementation-on-liver-and-lung-function-in-patients-with-hypopituitarism
#18
JOURNAL ARTICLE
J F Mao, H L Xu, Z X Liu, X Wang, B Q Yu, Y Y Zhu, W Ji, J Y Zhang, M Nie, X Y Wu
To analyze the clinical features of patients with anterior hypopituitarism (HP) complicated with cirrhosis, and to explore the effects of growth hormone supplementation on liver and lung function. A total of 11 patients with HP complicated with cirrhosis admitted to Peking Union Medical College Hospital from January 2016 to December 2022 were included in the study, including 8 males and 3 females, aged [ M ( Q 1 , Q 3 )]31 (20, 37) years. There were 6 patients with pituitary stalk interruption syndrome, 4 patients after craniopharyngioma resection, and 1 patient after germinal cell tumor chemoradiotherapy...
February 6, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38324081/subclinical-central-hypothyroidism-in-patients-with-hypothalamic-pituitary-disease-does-it-exist
#19
REVIEW
Julio Abucham, Manoel Martins
Central hypothyroidism (CH) is characterized by decreased thyroid hormone production due to insufficient stimulation of an otherwise normal thyroid gland by TSH. In patients with established hypothalamic-pituitary disease, a low FT4 concentration is considered highly specific, although poorly sensitive, for the diagnosis of CH. That would be comparable to diagnosing primary hypothyroidism in patients at risk only when serum FT4 concentrations are below the reference range, missing all patients with subclinical primary hypothyroidism and preventing proper therapy in patients in which thyroxine replacement is clearly beneficial...
February 7, 2024: Reviews in Endocrine & Metabolic Disorders
https://read.qxmd.com/read/38311995/-differential-diagnosis-and-tactics-of-managing-a-patient-with-primary-hypophysitis-on-the-example-of-a-clinical-case
#20
JOURNAL ARTICLE
N N Katamadze, A A Tskaeva, E A Pigarova, L K Dzeranova, N V Tarbaeva
In recent years, there has been a significant increase in the prevalence of autoimmune endocrinopathies, which are known to affect various levels of the endocrine system, including the pituitary gland. Hypophysitis is a general term used to describe any form of sellar and suprasellar inflammation that leads to structural changes in the hypothalamic-pituitary region and manifests itself in varying degrees of hormonal deficiency of the anterior and posterior pituitary glands. To date, there is a primary form of hypophysitis, which occurs as a result of an autoimmune lesion directly to the pituitary gland, and a secondary form of hypophysitis, which occurs as a result of the presence of a systemic autoimmune disease...
January 24, 2024: Problemy E̊ndokrinologii
keyword
keyword
77095
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.