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https://www.readbyqxmd.com/read/28275152/a-semisynthetic-streptococcus-pneumoniae-serotype-8-glycoconjugate-vaccine
#1
Benjamin Schumann, Heung Sik Hahm, Sharavathi G Parameswarappa, Katrin Reppe, Annette Wahlbrink, Subramanian Govindan, Paulina Kaplonek, Liise-Anne Pirofski, Martin Witzenrath, Chakkumkal Anish, Claney L Pereira, Peter H Seeberger
Glycoconjugate vaccines based on capsular polysaccharides (CPSs) of pathogenic bacteria such as Streptococcus pneumoniae successfully protect from disease but suffer from incomplete coverage, are troublesome to manufacture from isolated CPSs, and lack efficacy against certain serotypes. Defined, synthetic oligosaccharides are an attractive alternative to isolated CPSs but require the identification of immunogenic and protective oligosaccharide antigens. We describe a medicinal chemistry strategy based on a combination of automated glycan assembly (AGA), glycan microarray-based monoclonal antibody (mAb) reverse engineering, and immunological evaluation in vivo to uncover a protective glycan epitope (glycotope) for S...
March 8, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28273800/isar-imaging-of-ship-targets-based-on-an-integrated-cubic-phase-bilinear-autocorrelation-function
#2
Jibin Zheng, Hongwei Liu, Zheng Liu, Qing Huo Liu
For inverse synthetic aperture radar (ISAR) imaging of a ship target moving with ocean waves, the image constructed with the standard range-Doppler (RD) technique is blurred and the range-instantaneous-Doppler (RID) technique has to be used to improve the image quality. In this paper, azimuth echoes in a range cell of the ship target are modeled as noisy multicomponent cubic phase signals (CPSs) after the motion compensation and a RID ISAR imaging algorithm is proposed based on the integrated cubic phase bilinear autocorrelation function (ICPBAF)...
March 3, 2017: Sensors
https://www.readbyqxmd.com/read/28218649/smooth-sensor-motion-planning-for-robotic-cyber-physical-social-sensing-cpss
#3
Hong Tang, Liangzhi Li, Nanfeng Xiao
Although many researchers have begun to study the area of Cyber Physical Social Sensing (CPSS), few are focused on robotic sensors. We successfully utilize robots in CPSS, and propose a sensor trajectory planning method in this paper. Trajectory planning is a fundamental problem in mobile robotics. However, traditional methods are not suited for robotic sensors, because of their low efficiency, instability, and non-smooth-generated paths. This paper adopts an optimizing function to generate several intermediate points and regress these discrete points to a quintic polynomial which can output a smooth trajectory for the robotic sensor...
February 17, 2017: Sensors
https://www.readbyqxmd.com/read/28179606/carotid-plaque-score-and-risk-of-cardiovascular-mortality-in-the-oldest-old-results-from-the-tooth-study
#4
Takumi Hirata, Yasumichi Arai, Michiyo Takayama, Yukiko Abe, Kiyoshi Ohkuma, Toru Takebayashi
AIM: Accumulating evidence suggests that predictability of traditional cardiovascular risk factors declines with advancing age. We investigated whether carotid plaque scores (CPSs) were associated with cardiovascular disease (CVD) death in the oldest old, and whether asymmetrical dimethylarginine (ADMA), a marker of endothelial dysfunction, moderated the association between the CPS and CVD death. METHODS: We conducted a prospective cohort study of Japanese subjects aged ≥85 years without CVD at baseline...
February 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28177064/cpss-2-0-a-computational-platform-update-for-the-analysis-of-small-rna-sequencing-data
#5
Changlin Wan, Jianing Gao, Qiguang Zang, Rongjun Ban, Huan Zhang, Yuanwei Zhang
No abstract text is available yet for this article.
February 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28115276/allogeneic-hematopoietic-cell-transplantation-for-adult-chronic-myelomonocytic-leukemia
#6
Hien Duong Liu, Kwang Woo Ahn, Zhen-Huan Hu, Mehdi Hamadani, Taiga Nishihori, Baldeep Wirk, Amer Beitinjaneh, David Rizzieri, Michael R Grunwald, Mitchell Sabloff, Richard F Olsson, Ashish Bajel, Christopher Bredeson, Andrew Daly, Yoshihiro Inamoto, Navneet Majhail, Ayman Saad, Vikas Gupta, Aaron Gerds, Adriana Malone, Martin Tallman, Ran Reshef, David I Marks, Edward Copelan, Usama Gergis, Mary Lynn Savoie, Celalettin Ustun, Mark R Litzow, Jean-Yves Cahn, Tamila Kindwall-Keller, Gorgun Akpek, Bipin N Savani, Mahmoud Aljurf, Jacob M Rowe, Peter H Wiernik, Jack W Hsu, Jorge Cortes, Matt Kalaycio, Richard Maziarz, Ronald Sobecks, Uday Popat, Edwin Alyea, Wael Saber
Allogeneic hematopoietic cell transplantation (HCT) is potentially curative for patients with chronic myelomonocytic leukemia (CMML); however, few data exist regarding prognostic factors and transplantation outcomes. We performed this retrospective study to identify prognostic factors for post-transplantation outcomes. The CMML-specific prognostic scoring system (CPSS) has been validated in subjects receiving nontransplantation therapy and was included in our study. From 2001 to 2012, 209 adult subjects who received HCT for CMML were reported to the Center for International Blood and Marrow Transplant Research...
January 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28098772/a-non-intrusive-cyber-physical-social-sensing-solution-to-people-behavior-tracking-mechanism-prototype-and-field-experiments
#7
Yunjian Jia, Zhenyu Zhou, Fei Chen, Peng Duan, Zhen Guo, Shahid Mumtaz
Tracking people's behaviors is a main category of cyber physical social sensing (CPSS)-related people-centric applications. Most tracking methods utilize camera networks or sensors built into mobile devices such as global positioning system (GPS) and Bluetooth. In this article, we propose a non-intrusive wireless fidelity (Wi-Fi)-based tracking method. To show the feasibility, we target tracking people's access behaviors in Wi-Fi networks, which has drawn a lot of interest from the academy and industry recently...
January 13, 2017: Sensors
https://www.readbyqxmd.com/read/27886154/on-performance-analysis-of-protective-jamming-schemes-in-wireless-sensor-networks
#8
Xuran Li, Hong-Ning Dai, Hao Wang, Hong Xiao
Wireless sensor networks (WSNs) play an important role in Cyber Physical Social Sensing (CPSS) systems. An eavesdropping attack is one of the most serious threats to WSNs since it is a prerequisite for other malicious attacks. In this paper, we propose a novel anti-eavesdropping mechanism by introducing friendly jammers to wireless sensor networks (WSNs). In particular, we establish a theoretical framework to evaluate the eavesdropping risk of WSNs with friendly jammers and that of WSNs without jammers. Our theoretical model takes into account various channel conditions such as the path loss and Rayleigh fading, the placement schemes of jammers and the power controlling schemes of jammers...
November 24, 2016: Sensors
https://www.readbyqxmd.com/read/27882305/splenophrenic-portosystemic-shunt-in-dogs-with-and-without-portal-hypertension-can-acquired-and-congenital-porto-caval-connections-coexist
#9
M Ricciardi
The possible existence of the same pattern of porto-caval connection in dogs having a single congenital portosystemic shunt (CPSS) and in dogs having multiple acquired portosystemic shunt (MAPSS) secondary to portal hypertension (PH) was evaluated. Retrospective evaluation of all CT examinations of patients having portosystemic shunt (PSS) was performed in a 4-year time period. All anomalous porto-caval connections were assessed for anatomical pattern and compared with published veterinary literature. Records of 25 dogs were reviewed...
2016: Open veterinary journal
https://www.readbyqxmd.com/read/27865953/polysaccharide-of-caper-capparis-spinosa-l-leaf-extraction-optimization-antioxidant-potential-and-antimicrobial-activity
#10
Farzad Mazarei, Hossein Jooyandeh, Mohammad Noshad, Mohammad Hojjati
Three-variable-three-level Box-Behnken design-response surface methodology (BBD-RSM) based on the single-factor experiments was used to optimize the extracting parameters of crude polysaccharides (CPSs) from the Capparis spinosa leaves (CSL) including extraction time (ETi, 60-120min), extraction temperature (ETe, 60-80°C), and the water/solid ratio (W/S, 6-16). The optimal process conditions in order to the highest yield (6.73%) of CSL-CPSs were 119.8min ETi, 72.84°C ETe, and 15.97:1W/S.Structure of polysaccharide extracted at the optimal operating point were identified by Fourier transform-infrared spectroscopy (FT-IR)...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27855699/a-pilot-and-feasibility-randomised-controlled-study-of-prolonged-exposure-treatment-and-supportive-counselling-for-post-traumatic-stress-disorder-in-adolescents-a-third-world-task-shifting-community-based-sample
#11
Jaco Rossouw, Elna Yadin, Debra Alexander, Irene Mbanga, Tracy Jacobs, Soraya Seedat
BACKGROUND: There is a dearth of empirical evidence on the effectiveness of pharmacological and nonpharmacological treatments for adolescents with post-traumatic stress disorder (PTSD) in developing country settings. The primary aim of this study was to demonstrate that Prolonged Exposure Treatment for Adolescents (PE-A) and supportive counselling (SC) are implementable by nurses in a South African context. A secondary aim was to perform a preliminary analysis of the effectiveness of registered nurses delivering either PE-A or SC treatment to adolescents with PTSD...
November 17, 2016: Trials
https://www.readbyqxmd.com/read/27820134/using-a-bedside-algorithm-to-individually-dose-high-dose-methotrexate-for-patients-at-risk-for-toxicity
#12
Jennifer H Foster, Melanie B Bernhardt, Patrick A Thompson, E OʼBrian Smith, Eric S Schafer
We developed a bedside algorithm for individually adjusting the high-dose methotrexate (HDMTX) dose (5 g/m) given to patients with acute lymphoblastic leukemia at high risk for methotrexate toxicity. Data were reviewed for 8 patients receiving 21 cycles of HDMTX as per our algorithm. Eleven cycles began with 5 g/m, 10 cycles began with a preinfusion 20% to 25% dose reduction. Neither mean MTX AUC (2320.5±179.1 vs. 2080.4±161.7 μmol×h/L), mean Cpss (64.3±7.9 vs. 60.8±6.1 μM), nor toxicities were statistically different between groups...
January 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27809549/chemical-synthesis-of-the-repeating-unit-of-type-v-group-b-streptococcus-capsular-polysaccharide
#13
Jian Gao, Zhongwu Guo
The first chemical synthesis of the heptasaccharide repeating unit of type V group B Streptococcus capsular polysaccharide (CPS) by a preactivation-based one-pot [2 + 1 + 4] glycosylation strategy is described. The synthetic efficiency was further improved by using diol glycosyl acceptors for regio-/stereoselective glycosylation reactions. The synthetic target contains a free amino group at the reducing end, facilitating additional regioselective elaboration. The results should be useful for synthetic and biological studies of related CPSs...
November 4, 2016: Organic Letters
https://www.readbyqxmd.com/read/27775284/-congenital-portosistemic-shunt-importance-of-early-treatment
#14
N Vicente, M Pérez, R Gander, A Segarra, C Leganés, J Bueno
AIM: Congenital portosistemic shunt (CPSS) is an uncommon condition that can cause serious complications such as encephalopathy and liver tumors at risk of malignant degeneration. Occlusion of the shunt by surgery or interventional radiology can prevent and even improve such complications. In some cases, liver transplantation is the only curative option. We describe our experience with this condition. PATIENTS AND METHODS: Between 1992 and 2013, eight children (four male and four female) were diagnosed with CPSS (four extrahepatic and four intrahepatic) in our center, of which seven were diagnosed after 2007...
April 15, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27725523/an-assessment-of-the-medial-angle-of-inserted-subaxial-cervical-pedicle-screw-during-surgery-practical-use-of-preoperative-ct-scanning-and-intraoperative-x-rays
#15
Hong Bum Kim, Moon Kyu Lee, Young-Seok Lee, Jun-Young Sohn, Sang Ku Jung, Jin Hoon Park
The most important factor for cervical pedicle screw placement (CPS) is creating a sufficient medial angle. We aimed to know the medial angle of the inserted subaxial CPS during surgery using intraoperative AP X-rays. From March 2012 to September 2014, we performed posterior cervical fusions using CPS on 75 patients, including a total of 389 CPS insertions. Using preoperative CT scanning, we determined the θlat (i.e., an angle between a vertical line and a line to connect the planned entry point and the axial middle point of the pedicle) and θmed (i...
October 11, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27707835/examination-of-psychosocial-predictors-of-chinese-hospital-pharmacists-intention-to-provide-clinical-pharmacy-services-using-the-theory-of-planned-behaviour-a-cross-sectional-questionnaire-study
#16
Yuan He, Fan Yang, Dongqin Mu, Yuan Xing, Xin Li
OBJECTIVES: Main study aim was as follows: (1) to explore the usefulness of the theory of planned behaviour (TPB) model in predicting Chinese hospital pharmacists' intention to provide clinical pharmacy services (CPSs), including auxiliary CPSs and core CPSs; (2) to identify the main factors affecting the Chinese hospital pharmacists' intention to provide core CPSs based on TPB quantitatively. DESIGN: Cross-sectional questionnaire study. SETTING: The study was conducted in 22 general hospitals in seven cities located in the eastern and western part of China...
October 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27697318/surgical-strategy-according-to-the-anatomical-types-of-congenital-portosystemic-shunts-in-children
#17
Toshiharu Matsuura, Yoshiaki Takahashi, Yusuke Yanagi, Koichiro Yoshimaru, Kenichiro Yamamura, Eiji Morihana, Hazumu Nagata, Kiyoshi Uike, Hidetoshi Takada, Tomoaki Taguchi
BACKGROUND: Congenital portosystemic shunts (CPSS) with intrahepatic portal vein (IHPV) hypoplasia or absence cause encephalopathy or pulmonary hypertension (PH). Acute shunt closure may result in postoperative portal hypertension. The aim of this study was to propose a surgical strategy according to the anatomical types of CPSS and IHPV. METHODS: Twenty-three CPSS patients were diagnosed from1990 to 2015. All patients were evaluated by computed tomography, angiography, and PV pressure monitoring under a shunt occlusion test...
December 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27568478/utilizing-clinical-pharmacy-specialists-to-address-access-to-care-barriers-in-the-veteran-population-for-the-management-of-diabetes
#18
Krystal L Edwards, Ryan L Hadley, Nidhu Baby, Julianne C Yeary, Lisa M Chastain, Crystal D Brown
OBJECTIVE: To show that clinical pharmacy specialists (CPSs) can be utilized in remote facilities to provide appropriate diabetes outcomes along with potential cost savings. METHODS: A retrospective cohort chart review conducted at the Veterans Affairs North Texas Healthcare System (VANTHCS) evaluated outcomes in patients with type 2 diabetes mellitus referred to CPSs at Fort Worth Outpatient Clinic (FWOPC) or the endocrinologist-managed specialty clinic at the Dallas VA Medical Center (DVAMC)...
August 27, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27515266/analgesic-efficacy-of-oral-firocoxib-in-ovariohysterectomized-cats
#19
Prangtip Phuwapattanachart, Naris Thengchaisri
The post-operative analgesic effects of firocoxib in ovariohysterectomized cats were observed. Twenty-four cats were divided into 3 groups: control (no medicine), firocoxib-1 (1 mg/kg/day) and firocoxib-3 (3 mg/kg/day). Colorado pain scale scores (CPSS), composite pain scores (CPS), and buccal mucosal bleeding times (BMBT) were recorded in blinded fashion before induction and 2, 5, 8, 24, 30, and 48 hours post-operation. The average post-operative CPSS (mean±SEM) from 2 to 48 hours post-operation in firocoxib-3 (0...
August 10, 2016: Journal of Veterinary Science
https://www.readbyqxmd.com/read/27486981/targeted-deep-sequencing-improves-outcome-stratification-in-chronic-myelomonocytic-leukemia-with-low-risk-cytogenetic-features
#20
Laura Palomo, Olga Garcia, Montse Arnan, Blanca Xicoy, Francisco Fuster, Marta Cabezón, Rosa Coll, Vera Ademà, Javier Grau, Maria-José Jiménez, Helena Pomares, Sílvia Marcé, Mar Mallo, Fuensanta Millá, Esther Alonso, Anna Sureda, David Gallardo, Evarist Feliu, Josep-Maria Ribera, Francesc Solé, Lurdes Zamora
Clonal cytogenetic abnormalities are found in 20-30% of patients with chronic myelomonocytic leukemia (CMML), while gene mutations are present in >90% of cases. Patients with low risk cytogenetic features account for 80% of CMML cases and often fall into the low risk categories of CMML prognostic scoring systems, but the outcome differs considerably among them. We performed targeted deep sequencing of 83 myeloid-related genes in 56 CMML patients with low risk cytogenetic features or uninformative conventional cytogenetics (CC) at diagnosis, with the aim to identify the genetic characteristics of patients with a more aggressive disease...
August 30, 2016: Oncotarget
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