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Hong Bum Kim, Moon Kyu Lee, Young-Seok Lee, Jun-Young Sohn, Sang Ku Jung, Jin Hoon Park
The most important factor for cervical pedicle screw placement (CPS) is creating a sufficient medial angle. We aimed to know the medial angle of the inserted subaxial CPS during surgery using intraoperative AP X-rays. From March 2012 to September 2014, we performed posterior cervical fusions using CPS on 75 patients, including a total of 389 CPS insertions. Using preoperative CT scanning, we determined the θlat (i.e., an angle between a vertical line and a line to connect the planned entry point and the axial middle point of the pedicle) and θmed (i...
October 11, 2016: Neurologia Medico-chirurgica
Yuan He, Fan Yang, Dongqin Mu, Yuan Xing, Xin Li
OBJECTIVES: Main study aim was as follows: (1) to explore the usefulness of the theory of planned behaviour (TPB) model in predicting Chinese hospital pharmacists' intention to provide clinical pharmacy services (CPSs), including auxiliary CPSs and core CPSs; (2) to identify the main factors affecting the Chinese hospital pharmacists' intention to provide core CPSs based on TPB quantitatively. DESIGN: Cross-sectional questionnaire study. SETTING: The study was conducted in 22 general hospitals in seven cities located in the eastern and western part of China...
October 5, 2016: BMJ Open
Toshiharu Matsuura, Yoshiaki Takahashi, Yusuke Yanagi, Koichiro Yoshimaru, Kenichiro Yamamura, Eiji Morihana, Hazumu Nagata, Kiyoshi Uike, Hidetoshi Takada, Tomoaki Taguchi
BACKGROUND: Congenital portosystemic shunts (CPSS) with intrahepatic portal vein (IHPV) hypoplasia or absence cause encephalopathy or pulmonary hypertension (PH). Acute shunt closure may result in postoperative portal hypertension. The aim of this study was to propose a surgical strategy according to the anatomical types of CPSS and IHPV. METHODS: Twenty-three CPSS patients were diagnosed from1990 to 2015. All patients were evaluated by computed tomography, angiography, and PV pressure monitoring under a shunt occlusion test...
September 21, 2016: Journal of Pediatric Surgery
Krystal L Edwards, Ryan L Hadley, Nidhu Baby, Julianne C Yeary, Lisa M Chastain, Crystal D Brown
OBJECTIVE: To show that clinical pharmacy specialists (CPSs) can be utilized in remote facilities to provide appropriate diabetes outcomes along with potential cost savings. METHODS: A retrospective cohort chart review conducted at the Veterans Affairs North Texas Healthcare System (VANTHCS) evaluated outcomes in patients with type 2 diabetes mellitus referred to CPSs at Fort Worth Outpatient Clinic (FWOPC) or the endocrinologist-managed specialty clinic at the Dallas VA Medical Center (DVAMC)...
August 27, 2016: Journal of Pharmacy Practice
Prangtip Phuwapattanachart, Naris Thengchaisri
The post-operative analgesic effects of firocoxib in ovariohysterectomized cats were observed. Twenty-four cats were divided into 3 groups: control (no medicine), firocoxib-1 (1 mg/kg/day) and firocoxib-3 (3 mg/kg/day). Colorado pain scale scores (CPSS), composite pain scores (CPS), and buccal mucosal bleeding times (BMBT) were recorded in blinded fashion before induction and 2, 5, 8, 24, 30, and 48 hours post-operation. The average post-operative CPSS (mean±SEM) from 2 to 48 hours post-operation in firocoxib-3 (0...
August 10, 2016: Journal of Veterinary Science
Laura Palomo, Olga Garcia, Montse Arnan, Blanca Xicoy, Francisco Fuster, Marta Cabezón, Rosa Coll, Vera Ademà, Javier Grau, Maria-José Jiménez, Helena Pomares, Sílvia Marcé, Mar Mallo, Fuensanta Millá, Esther Alonso, Anna Sureda, David Gallardo, Evarist Feliu, Josep-Maria Ribera, Francesc Solé, Lurdes Zamora
Clonal cytogenetic abnormalities are found in 20-30% of patients with chronic myelomonocytic leukemia (CMML), while gene mutations are present in >90% of cases. Patients with low risk cytogenetic features account for 80% of CMML cases and often fall into the low risk categories of CMML prognostic scoring systems, but the outcome differs considerably among them. We performed targeted deep sequencing of 83 myeloid-related genes in 56 CMML patients with low risk cytogenetic features or uninformative conventional cytogenetics (CC) at diagnosis, with the aim to identify the genetic characteristics of patients with a more aggressive disease...
July 29, 2016: Oncotarget
Evgueny Vinogradov, Guillaume Goyette-Desjardins, Masatoshi Okura, Daisuke Takamatsu, Marcelo Gottschalk, Mariela Segura
Streptococcus suis serotype 9 is the most prevalent S. suis serotype in several European countries. In spite of its pathogenicity for pigs and increasing zoonotic potential, limited information is available on this serotype. Here we determined for the first time the chemical composition and structure of serotype 9 capsular polysaccharide (CPS), a major bacterial virulence factor and the antigen at the origin of S. suis classification into serotypes. Chemical and spectroscopic data gave the repeating unit sequence: [3)Glcol-6-P-3-[D-Gal(α1-2)]D-Gal(β1-3)D-Sug(β1-3)L-Rha(α1-)]n...
October 4, 2016: Carbohydrate Research
Aileen M Gariepy, Lisbet S Lundsberg, Devin Miller, Nancy L Stanwood, Kimberly A Yonkers
BACKGROUND: Pregnancy planning and timing may be associated with psychiatric illness, psychological distress and support during pregnancy. METHODS: We performed secondary analyses of a prospective cohort of 2654 pregnant women evaluating the impact of depression on preterm birth. We used multivariable logistic regression to test associations between pregnancy planning ("Was this pregnancy planned? Yes/No") and/or timing ("Do you think this is a good time for you to be pregnant?") with Composite International Diagnostic Interview generated psychiatric diagnoses and measures of psychological distress and support...
June 27, 2016: Journal of Affective Disorders
Chiara Elena, Anna Gallì, Esperanza Such, Manja Meggendorfer, Ulrich Germing, Ettore Rizzo, Jose Cervera, Elisabetta Molteni, Annette Fasan, Esther Schuler, Ilaria Ambaglio, Maria Lopez-Pavia, Silvia Zibellini, Andrea Kuendgen, Erica Travaglino, Reyes Sancho-Tello, Silvia Catricalà, Ana I Vicente, Torsten Haferlach, Claudia Haferlach, Guillermo F Sanz, Luca Malcovati, Mario Cazzola
Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm with variable clinical course. To predict the clinical outcome, we previously developed a CMML-specific prognostic scoring system (CPSS) based on clinical parameters and cytogenetics. In this work, we tested the hypothesis that accounting for gene mutations would further improve risk stratification of CMML patients. We therefore sequenced 38 genes to explore the role of somatic mutations in disease phenotype and clinical outcome...
September 8, 2016: Blood
Fabricio O Lima, Gisele S Silva, Karen L Furie, Michael R Frankel, Michael H Lev, Érica C S Camargo, Diogo C Haussen, Aneesh B Singhal, Walter J Koroshetz, Wade S Smith, Raul G Nogueira
BACKGROUND AND PURPOSE: Patients with large vessel occlusion strokes (LVOS) may be better served by direct transfer to endovascular capable centers avoiding hazardous delays between primary and comprehensive stroke centers. However, accurate stroke field triage remains challenging. We aimed to develop a simple field scale to identify LVOS. METHODS: The Field Assessment Stroke Triage for Emergency Destination (FAST-ED) scale was based on items of the National Institutes of Health Stroke Scale (NIHSS) with higher predictive value for LVOS and tested in the Screening Technology and Outcomes Project in Stroke (STOPStroke) cohort, in which patients underwent computed tomographic angiography within the first 24 hours of stroke onset...
August 2016: Stroke; a Journal of Cerebral Circulation
Eric Grignano, Arsene Mekinian, Thorsten Braun, Eric Liozon, Mohamed Hamidou, Olivier Decaux, Xavier Puéchal, Jean Emmanuel Kahn, Yoland Schoindre, Julien Rossignol, Olivier Lortholary, Bertrand Lioger, Olivier Hermine, Sophie Park, Lionel Ades, François Montestruc, Laure Ricard, Claude Gardin, Pierre Fenaux, Olivier Fain
We wanted to describe the characteristics, treatment and outcome of autoimmune and inflammatory diseases (SAIDs) associated with chronic myelomonocytic leukemia (CMML), and conducted a French multicenter retrospective study and a literature review. We included 26 cases of CMML (median age 75 years, 54% female), 80% with CMML-1. CPSS score was low (0 or 1) in 75% of cases. SAIDS was systemic vasculitis in 54%. Diagnosis of the 2 diseases was concomitant in 31% cases, and CMML was diagnosed before SAIDs in 12 cases (46%)...
August 2016: Leukemia Research
Shivangi Sachdeva, Narendar Kolimi, Sanjana Anilkumar Nair, Thenmalarchelvi Rathinavelan
Capsular polysaccharides (CPSs) are major bacterial virulent determinants that facilitate host immune evasion. E. coli group1 K30CPS is noncovalently attached to bacterial surface by Wzi, a lectin. Intriguingly, structure based phylogenetic analysis indicates that Wzi falls into porin superfamily. Molecular dynamics (MD) simulations further shed light on dual role of Wzi as it also functions as a bidirectional passive water specific porin. Such a functional role of Wzi was not realized earlier, due to the occluded pore...
2016: Scientific Reports
Takeshi Terashima, Tatsuya Yamashita, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
There is no established treatment for patients with advanced hepatocellular carcinoma (HCC) with Child-Pugh class B cirrhosis. The aim of the present study was to assess the efficacy of hepatic arterial infusion chemotherapy (HAIC) according to Child-Pugh score (CPS) and to evaluate the correlation of a patient's response to HAIC with hepatic reserve and outcome. We retrospectively reviewed the medical records of 377 patients treated with HAIC between March 2003 and February 2015. Subjects included 179 with Child-Pugh class B...
September 2016: Cancer Science
Jyotsna Sharma, Pampa Ch Toi, Neelaiah Siddaraju, Malliga Sundareshan, Syed Habeebullah
BACKGROUND: The role of Papanicolaou (Pap) test in cervical cancer screening need not be overemphasized. While most Western countries have adopted the liquid-based cytology (LBC), which is considered superior, many developing countries are still using the conventional Pap smear (CPS) technique. OBJECTIVE: To compare the staining and cytomorphological features on conventional versus liquid-based cervicovaginal smears. MATERIALS AND METHODS: One hundred and forty cervicovaginal smears prepared by the standard conventional and LBC techniques were interpreted as per the Bethesda system of reporting cervicovaginal smears...
April 2016: Journal of Cytology
Nobuyuki Shimokawa, Toshihiro Takami
Cervical pedicle screw (CPS) may be the biomechanically best system for posterior cervical segmental fixation, but may carry a surgery-related risk. The purpose of this study was to evaluate the safety of CPS placement using computer navigation system for posterior cervical instrumented fixation and discuss its complication avoidance and management. Posterior cervical instrumented fixation using CPS was performed in a total of 128 patients during the period between 2007 and 2015. Intraoperative image guidance was achieved using a preoperative 3D CT-based or an intraoperative 3D CT-based navigation system...
May 31, 2016: Neurosurgical Review
Mark T Mackay, Leonid Churilov, Geoffrey A Donnan, Franz E Babl, Paul Monagle
OBJECTIVE: To assess the utility of the Cincinnati Prehospital Stroke Scale (CPSS) and Recognition of Stroke in the Emergency Room (ROSIER) tools in children presenting to the emergency department (ED) with brain attack symptoms. METHODS: The ROSIER and CPSS tools were retrospectively applied to 101 children with stroke, presenting from 2003 to 2010, and prospectively to 279 children with mimics, presenting from 2009 to 2010. Positive CPSS was defined as ≥1 positive sign (face/asymmetrical arm weakness, speech disturbance)...
June 7, 2016: Neurology
Francesco Ferracuti, Alessandro Freddi, Andrea Monteriù, Mariorosario Prist
The integration of Wireless Sensors Networks (WSNs) into Cyber Physical Systems (CPSs) is an important research problem to solve in order to increase the performances, safety, reliability and usability of wireless automation systems. Due to the complexity of real CPSs, emulators and simulators are often used to replace the real control devices and physical connections during the development stage. The most widespread simulators are free, open source, expandable, flexible and fully integrated into mathematical modeling tools; however, the connection at a physical level and the direct interaction with the real process via the WSN are only marginally tackled; moreover, the simulated wireless sensor motes are not able to generate the analogue output typically required for control purposes...
2016: Sensors
Yuanwei Zhang, Qiguang Zang, Bo Xu, Wei Zheng, Rongjun Ban, Huan Zhang, Yifan Yang, Qiaomei Hao, Furhan Iqbal, Ao Li, Qinghua Shi
UNLABELLED: : Next-Generation Sequencing (NGS) technology has revealed that microRNAs (miRNAs) are capable of exhibiting frequent differences from their corresponding mature reference sequences, generating multiple variants: the isoforms of miRNAs (isomiRs). These isomiRs mainly originate via the imprecise and alternative cleavage during the pre-miRNA processing and post-transcriptional modifications that influence miRNA stability, their sub-cellular localization and target selection...
July 1, 2016: Bioinformatics
Marissa Escobar Quinones, Margaret Youngmi Pio, Diem Hong Chow, Elizabeth Moss, Jeffrey Lynn Hulstein, Steven Michael Boatright, Annie Mathew
OBJECTIVES: To provide a review of the outcomes and costs in patients seen by Clinical Pharmacy Specialist (CPS) Certified Diabetes Educators in ambulatory care for diabetes management. STUDY DESIGN: A retrospective chart review. METHODS: All patients discharged by a CPS for diabetes management between January 1, 2010, and December 31, 2013, were included. RESULTS: A total of 915 patients were discharged from CPS services...
2016: American Journal of Managed Care
Ming-Ju Hsieh, Sung-Chun Tang, Wen-Chu Chiang, Li-Kai Tsai, Jiann-Shing Jeng, Matthew Huei-Ming Ma
BACKGROUND: The sooner thrombolytic therapy is given to acute ischemic stroke patients, the better the outcome. Prehospital notification may shorten the time between hospital arrival and brain computed tomography (door-to-CT) and the door-to-needle (DTN) time. This study investigated the effect of prehospital notification on acute stroke care in an urban city in Taiwan. METHODS: This retrospective observational study utilized a prospectively collected dataset from patients treated at 9 hospitals and the emergency medical service (EMS) system in Taipei City from September 1, 2012 to December 31, 2014...
2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
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