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David Roy, Daisuke Takamatsu, Masatoshi Okura, Guillaume Goyette-Desjardins, Marie-Rose Van Calsteren, Audrey Dumesnil, Marcelo Gottschalk, Mariela Segura
The capsular polysaccharide (CPS) represents a key virulence factor for most encapsulated streptococci. Streptococcus suis and Group B Streptococcus (GBS) are both well-encapsulated pathogens of clinical importance in veterinary and/or human medicine and responsible for invasive systemic diseases. S. suis and GBS are the only Gram-positive bacteria which express a sialylated CPS at their surface. An important difference between these two sialylated CPSs is the linkage between the side-chain terminal galactose and sialic acid, being α-2,6 for S...
2018: Frontiers in Microbiology
Hao Wang, Nathan Lau, Ryan M Gerdes
OBJECTIVE: The aim of this study was to apply work domain analysis for cybersecurity assessment and design of supervisory control and data acquisition (SCADA) systems. BACKGROUND: Adoption of information and communication technology in cyberphysical systems (CPSs) for critical infrastructures enables automated and distributed control but introduces cybersecurity risk. Many CPSs employ SCADA industrial control systems that have become the target of cyberattacks, which inflict physical damage without use of force...
April 1, 2018: Human Factors
Zhenyu Wu, Yang Guo, Wenfang Lin, Shuyang Yu, Yang Ji
Predictive maintenance plays an important role in modern Cyber-Physical Systems (CPSs) and data-driven methods have been a worthwhile direction for Prognostics Health Management (PHM). However, two main challenges have significant influences on the traditional fault diagnostic models: one is that extracting hand-crafted features from multi-dimensional sensors with internal dependencies depends too much on expertise knowledge; the other is that imbalance pervasively exists among faulty and normal samples. As deep learning models have proved to be good methods for automatic feature extraction, the objective of this paper is to study an optimized deep learning model for imbalanced fault diagnosis for CPSs...
April 5, 2018: Sensors
Nee-Kofi Mould-Millman, Halea Meese, Ibthial Alattas, Moges Ido, Iasson Yi, Tolulope Oyewumi, Michael Colman, Michael Frankel, Arthur Yancey
OBJECTIVE: Strokes are a leading cause of morbidity and mortality in the United States, especially in the "stroke belt" of the southeast. Up to 65% of stroke patients access care by calling 9-1-1. The primary objective of this study is to measure the accuracy of emergency medical dispatchers (EMD) and paramedics, in the prehospital identification of stroke. METHODS: The study was based at Grady Emergency Medical Services, which is Atlanta, Georgia's public emergency medical services (EMS) provider...
March 29, 2018: Prehospital Emergency Care
Bin Zhou, Daoyou Huang, Jinshui Wu, Qihong Zhu, Hanhua Zhu
To study the horizontal and vertical distribution of chromium (Cr) in the soil of a chromate production site (CPS) and its nearby area (NA-CPS) in south central China, 61 profiles (depth: 14 m) in the CPS and 69 samples (topsoil) were excavated following a grid-sampling method. The geographic coordinates, elevation, and types of soil layers were recorded, and the total Cr in the soil and the total Cr and Cr(VI) in the leachate of the soil and in the groundwater were determined. Migration of Cr in surface soils may be represented in terms of a multiple linear regression equation ( R ²adj = 0...
March 22, 2018: International Journal of Environmental Research and Public Health
Nilanjan Dey, Amira S Ashour, Fuqian Shi, Simon James Fong, João Manuel R S Tavares
Medical cyber-physical systems (MCPS) are healthcare critical integration of a network of medical devices. These systems are progressively used in hospitals to achieve a continuous high-quality healthcare. The MCPS design faces numerous challenges, including inoperability, security/privacy, and high assurance in the system software. In the current work, the infrastructure of the cyber-physical systems (CPS) are reviewed and discussed. This article enriched the researches of the networked Medical Device (MD) systems to increase the efficiency and safety of the healthcare...
March 10, 2018: Journal of Medical Systems
L Franco-Trigo, J Tudball, D Fam, S I Benrimoj, D Sabater-Hernández
BACKGROUND: Collaboration between relevant stakeholders in health service planning enables service contextualization and facilitates its success and integration into practice. Although community pharmacy services (CPSs) aim to improve patients' health and quality of life, their integration in primary care is far from ideal. Key stakeholders for the development of a CPS intended at preventing cardiovascular disease were identified in a previous stakeholder analysis. Engaging these stakeholders to create a shared vision is the subsequent step to focus planning directions and lay sound foundations for future work...
February 21, 2018: Research in Social & Administrative Pharmacy: RSAP
Daniel Sabater-Hernández, Jacqueline Tudball, Caleb Ferguson, Lucía Franco-Trigo, Lutfun N Hossain, Shalom I Benrimoj
BACKGROUND: Community pharmacies provide a suitable setting to promote self-screening programs aimed at enhancing the early detection of atrial fibrillation (AF). Developing and implementing novel community pharmacy services (CPSs) is a complex and acknowledged challenge, which requires comprehensive planning and the participation of relevant stakeholders. Co-design processes are participatory research approaches that can enhance the development, evaluation and implementation of health services...
February 27, 2018: BMC Health Services Research
Minseok Kim, George V Eleftheriades
We propose a new family of impedance-matched chiral metasurfaces that offer arbitrary polarization control at two different frequencies. To this end, two main problems are addressed: (1) determination of the required surface impedances for a certain user-defined chiral functionality at two frequencies and (2) their physical realization at microwaves. The first milestone is achieved through a proposed synthesis method that combines a semi-analytical method and a nonlinear optimization technique. In particular, the impedances are computed such that the devised chiral metasurface is also impedance-matched to a terminating medium...
February 22, 2018: Scientific Reports
Ting-Wei Chen, Szu-Cheng Cheng
This paper presents numerical studies of cavity polariton solitons (CPSs) in a resonantly pumped semiconductor microcavity with an imbedded spatial defect. In the bistable regime of the well-known homogeneous polariton condensate, with proper incident wave vector and pump strength, bright and/or dark cavity solitons can be found in the presence of a spatially confined potential. The minimum pump strength required to observe the CPSs or nonlinear localized states in this parametric pump scheme is therefore reported...
January 2018: Physical Review. E
Linlin Zhang, Yiwei Weng, Yu Wu, Xueying Wang, Zhe Yin, Huiying Yang, Wenhui Yang, Yiquan Zhang
Vibrio parahaemolyticus is capable of surviving in biofilm communities attached to biotic and abiotic surfaces. The exopolysaccharide (EPS) plays a key role in the maturing of the biofilm. The VPA1403-1412 (cpsA-J) operon is responsible for EPS production in V. parahaemolyticus. The expression of cpsA-J is controlled by ScrABC, intracellular concentration of c-di-GMP, CpsS-CpsR-CpsQ regulatory cascade, and quorum sensing. The data presented here showed that H-NS activates the EPS-dependent bacterial colony morphology and the transcription of cpsQ and cpsA-J...
March 2018: Microbial Pathogenesis
Elena R Serrano-Ibáñez, Gema T Ruiz-Párraga, Rosa Esteve, Carmen Ramírez-Maestre, Alicia E López-Martínez
BACKGROUND: One of the most frequently used instruments to assess posttraumatic stress in children and adolescents is the Child PTSD Symptom Scale. However, there has been limited evaluation of its construct validity in the Spanish language despite Spanish being one of the most widely spoken languages in the world. OBJECTIVE: To provide data on the psychometric properties of the CPSS in a sample of Spanish adolescents, to establish the internal consistency of the measure, and to examine its criterion validity...
February 2018: Psicothema
Charlotta Vinterflod, Maria Gustafsson, Sofia Mattsson, Gisselle Gallego
BACKGROUND: In many countries, clinical pharmacists are part of health care teams that work to optimize drug therapy and ensure patient safety. However, in Sweden, clinical pharmacy services (CPSs) in hospital settings have not been widely implemented and regional differences exist in the uptake of these services. Physicians' attitudes toward CPSs and collaborating with clinical pharmacists may facilitate or hinder the implementation and expansion of the CPSs and the role of the clinical pharmacist in hospital wards...
January 24, 2018: BMC Health Services Research
Shuang Yang, Daoyi Xi, Fuyi Jing, Deju Kong, Junli Wu, Lu Feng, Boyang Cao, Lei Wang
Capsular polysaccharides (CPSs), or K-antigens, are the major surface antigens of Escherichia coli. More than 80 serologically unique K-antigens are classified into 4 groups (Groups 1-4) of capsules. Groups 1 and 4 contain the Wzy-dependent polymerization pathway and the gene clusters are in the order galF to gnd; Groups 2 and 3 contain the ABC-transporter-dependent pathway and the gene clusters consist of 3 regions, regions 1, 2 and 3. Little is known about the variations among the gene clusters. In this study, 9 serotypes of K-antigen gene clusters (K2ab, K11, K20, K24, K38, K84, K92, K96, and K102) were sequenced and correlated with their CPS chemical structures...
April 2018: Canadian Journal of Microbiology
Johanna J Kenyon, Anastasiya A Kasimova, Alexander S Shashkov, Ruth M Hall, Yuriy A Knirel
The structures of capsular polysaccharides (CPSs) produced by different Acinetobacter baumannii strains have proven to be invaluable in confirming the role of specific genes in the synthesis of rare sugars through the correlation of genetic content at the CPS biosynthesis locus with sugars found in corresponding CPS structures. A module of four genes (rmlA, rmlB, vioA and vioB) was identified in the KL57 capsule biosynthesis gene cluster of A. baumannii isolate BAL_212 from Vietnam. These genes were predicted to direct the synthesis of 4-acetamido-4,6-dideoxy-d-glucose (N-acetylviosamine, d-Qui4NAc) and the K57 CPS was found to contain this monosaccharide...
February 2018: Microbiology
Christopher T Richards, Ryan Huebinger, Katie L Tataris, Joseph M Weber, Laura Eggers, Eddie Markul, Leslee Stein-Spencer, Kenneth S Pearlman, Jane L Holl, Shyam Prabhakaran
OBJECTIVE: Accurate prehospital identification of patients with acute ischemic stroke (AIS) from large vessel occlusion (LVO) facilitates direct transport to hospitals that perform endovascular thrombectomy. We hypothesize that a cut-off score of the Cincinnati Prehospital Stroke Scale (CPSS), a simple assessment tool currently used by emergency medical services (EMS) providers, can be used to identify LVO. METHODS: Consecutively enrolled, confirmed AIS patients arriving via EMS between August 2012 and April 2014 at a high-volume stroke center in a large city with a single municipal EMS provider agency were identified in a prospective, single-center registry...
January 3, 2018: Prehospital Emergency Care
Stephen W English, Alejandro A Rabinstein, Jay Mandrekar, James P Klaas
BACKGROUND AND PURPOSE: Although prehospital stroke notification has improved stroke treatment, incorporation of these systems into existing infrastructure has resulted in new challenges. The goal of our study was to design an effective prehospital notification system that allows for early and accurate identification of patients presenting with acute stroke. METHODS: We conducted a retrospective single-center cohort study of patients presenting with suspicion of acute stroke from 2014 to 2015...
April 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Caitlin E Tzounos, Michael S Tivers, Sophie E Adamantos, Kate English, Alan L Rees, Vicky J Lipscomb
Objectives The objectives of this study were, first, to report the haematological parameters and coagulation times for cats with a congenital portosystemic shunt (CPSS) and the influence of surgical shunt attenuation on these parameters; and, second, to identify any association between prolongation in coagulation profiles and incidence of perioperative haemorrhage. Methods This was a retrospective clinical study using client-owned cats with a CPSS. Signalment, shunt type (extra- or intrahepatic), degree of shunt attenuation (complete or partial), haematological parameters, prothrombin time (PT) and activated partial thromboplastin time (aPTT) test results, and occurrence of any perioperative clinical bleeding complications were recorded for cats undergoing surgical treatment of a CPSS at the Royal Veterinary College, UK, between 1994 and 2011...
December 2017: Journal of Feline Medicine and Surgery
Peng Zhou, Decheng Zuo, Kun-Mean Hou, Zhan Zhang
Cyber Physical Systems (CPSs) need to interact with the changeable environment under various interferences. To provide continuous and high quality services, a self-managed CPS should automatically reconstruct itself to adapt to these changes and recover from failures. Such dynamic adaptation behavior introduces systemic challenges for CPS design, advice evaluation and decision process arrangement. In this paper, a formal compositional framework is proposed to systematically improve the dependability of the decision process...
November 9, 2017: Sensors
D Schumann, J Langhorst, G Dobos, H Cramer
BACKGROUND: Irritable bowel syndrome is the most frequent gastrointestinal disorder. It is assumed that lifestyle interventions might be a rational treatment approach. AIM: To examine the effect of a yoga-based intervention vs a low-FODMAP diet on patients with irritable bowel syndrome. METHODS: Fifty-nine patients with irritable bowel syndrome undertook a single-blind, randomised controlled trial involving yoga or a low-FODMAP diet for 12 weeks...
January 2018: Alimentary Pharmacology & Therapeutics
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