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https://www.readbyqxmd.com/read/29223987/radiosurgery-for-brain-metastases-changing-practice-patterns-and-disparities-in-the-united-states
#1
Benjamin H Kann, Henry S Park, Skyler B Johnson, Veronica L Chiang, James B Yu
Background: Management of brain metastases typically includes radiotherapy (RT) with conventional fractionation and/or stereotactic radiosurgery (SRS). However, optimal indications and practice patterns for SRS remain unclear. We sought to evaluate national practice patterns for patients with metastatic disease receiving brain RT. Methods: We queried the National Cancer Data Base (NCDB) for patients diagnosed with metastatic non-small cell lung cancer, breast cancer, colorectal cancer, or melanoma from 2004 to 2014 who received upfront brain RT...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29223551/recent-advances-in-delivery-of-antifungal-agents-for-therapeutic-management-of-candidiasis
#2
REVIEW
Bhakti Sawant, Tabassum Khan
Candidiasis is a fungal infection caused by yeasts that belong to the genus Candida. There are over twenty species of Candida yeasts that can cause infection in humans, the most common of which is Candida albicans. Candida yeasts normally reside in the intestinal tract and can be found on mucous membranes and skin without causing infection; however, overgrowth of these organisms can cause symptoms to develop. Presence of other diseases that compromises the patient's immunity makes it more difficult to treat...
December 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29223188/disordered-eating-in-sami-and-non-sami-norwegian-populations-the-saminor-2-clinical-survey
#3
Kirsti Kvaløy, Marita Melhus, Anne Silviken, Magritt Brustad, Tore Sørlie, Ann Ragnhild Broderstad
OBJECTIVE: The present study aimed to investigate disordered eating (DE) among Sami compared with non-Sami residing in northern Norway. DESIGN: In a cross-sectional design, stratified by sex and ethnicity, associations were tested between DE (Eating Disturbance Scale; EDS-5) and age, education level, BMI category, anxiety and depression, physical activity and consumption of snacks. SETTING: The SAMINOR 2 Clinical Survey (2012-2014) based on the population of ten municipalities in northern Norway...
December 10, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29222989/disrupted-circuits-in-mouse-models-of-autism-spectrum-disorder-and-intellectual-disability
#4
REVIEW
Carla Em Golden, Joseph D Buxbaum, Silvia De Rubeis
Autism spectrum disorder (ASD) and intellectual disability (ID) are caused by a wide range of genetic mutations, a significant fraction of which reside in genes important for synaptic function. Studies have found that sensory, prefrontal, hippocampal, cerebellar, and striatal regions, as well as the circuits that connect them, are perturbed in mouse models of ASD and ID. Dissecting the disruptions in morphology and activity in these neural circuits might help us to understand the shared risk between the two disorders as well as their clinical heterogeneity...
December 5, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29221805/skeletal-muscle-regenerative-potential-of-human-mustem-cells-following-transplantation-into-injured-mice-muscle
#5
Judith Lorant, Charlotte Saury, Cindy Schleder, Florence Robriquet, Blandine Lieubeau, Elisa Négroni, Isabelle Leroux, Lucie Chabrand, Sabrina Viau, Candice Babarit, Mireille Ledevin, Laurence Dubreil, Antoine Hamel, Armelle Magot, Chantal Thorin, Laëtitia Guevel, Bruno Delorme, Yann Péréon, Gillian Butler-Browne, Vincent Mouly, Karl Rouger
After intra-arterial delivery in the dystrophic dog, allogeneic muscle-derived stem cells, termed MuStem cells, contribute to long-term stabilization of the clinical status and preservation of the muscle regenerative process. However, it remains unknown whether the human counterpart could be identified, considering recent demonstrations of divergent features between species for several somatic stem cells. Here, we report that MuStem cells reside in human skeletal muscle and display a long-term ability to proliferate, allowing generation of a clinically relevant amount of cells...
October 20, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29221580/mechanisms-of-allergen-immunotherapy-for-inhaled-allergens-and-predictive-biomarkers
#6
REVIEW
Mohamed H Shamji, Stephen R Durham
Allergen immunotherapy is effective in patients with IgE-dependent allergic rhinitis and asthma. When immunotherapy is given continuously for 3 years, there is persistent clinical benefit for several years after its discontinuation. This disease-modifying effect is both antigen-specific and antigen-driven. Clinical improvement is accompanied by decreases in numbers of effector cells in target organs, including mast cells, basophils, eosinophils, and type 2 innate lymphoid cells. Immunotherapy results in the production of blocking IgG/IgG4 antibodies that can inhibit IgE-dependent activation mediated through both high-affinity IgE receptors (FcεRI) on mast cells and basophils and low-affinity IgE receptors (FcεRII) on B cells...
December 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29221502/impact-of-cardiorespiratory-fitness-on-frequency-of-atrial-fibrillation-stroke-and-all-cause-mortality
#7
Nasir Hussain, Bernard J Gersh, Karina Gonzalez Carta, Nóra Sydó, Francisco Lopez-Jimenez, Stephen L Kopecky, Randal J Thomas, Samuel J Asirvatham, Thomas G Allison
Benefits of cardiorespiratory fitness on cardiovascular health are well recognized, but the impact on incidence of atrial fibrillation (AF) and stroke, and, particularly, risk of stroke and mortality in patients with AF is less clear. From 1993 to 2010, patients referred for a treadmill exercise test (TMET) at the Mayo Clinic Rochester, MN, were retrospectively identified (N = 76,857). From this, 14,094 local residents were selected. Exclusions were age <18 years; history of heart failure, structural or valvular heart disease, AF or flutter, or stroke...
January 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29219910/the-appraisal-of-nursing-practice-instrument-development-and-initial-testing
#8
Heather Becker, Marty Meraviglia, Jin EunJin Seo, Chipo Ndlovu, Lois Kimmel, Toni Rowin
OBJECTIVE: We describe the development of the Appraisal of Nursing Practice (ANP) and present initial psychometric data. BACKGROUND: Although measures of new nurses' confidence in clinical practice exist, psychometrically sound observational tools that assess a broad range of nursing competencies are needed. METHODS: Based on the Quality and Safety Education for Nurses competencies, the 37-item ANP covers person-centered care, teamwork and collaboration, evidence-based practice/quality improvement, safety, informatics, professionalism, and overall satisfaction (with the new nurse's functioning)...
January 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29219906/targeted-interventions-to-advance-a-culture-of-inquiry-at-a-large-multicampus-hospital-among-nurses
#9
Eileen J Carter, Reynaldo R Rivera, Kelly A Gallagher, Kenrick D Cato
OBJECTIVES: The aim of this study is to assist nurse leaders in developing innovative structures to foster a culture of inquiry among professional nurses. BACKGROUND: Critical to nurse's engagement in evidence-based practice (EBP) is a culture of inquiry, in which nurses critically evaluate patient care activities and actively review existing evidence to address identified clinical issues. A bundle of structural interventions was implemented across a large, multisite hospital to advance a culture of inquiry...
January 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29219894/crisis-management-simulation-establishing-a-dual-neurosurgery-and-anesthesia-training-experience
#10
Jeremy Ciporen, Haley Gillham, Michele Noles, Dawn Dillman, Mark Baskerville, Caleb Haley, Donn Spight, Ryan C Turner, Brandon P Lucke-Wold
BACKGROUND: Simulation training has been shown to be an effective teaching tool. Learner management of an intraoperative crisis such as a major cerebrovascular bleed requires effective teamwork, communication, and implementation of key skill sets at appropriate time points. This study establishes a first of a kind simulation experience in a neurosurgery/anesthesia resident (learners) team working together to manage an intraoperative crisis. METHODS: Using a cadaveric cavernous carotid injury perfusion model, 7 neurosurgery and 6 anesthesia learners, were trained on appropriate vascular injury management using an endonasal endoscopic technique...
January 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29219656/modulating-secreted-components-of-tumor-microenvironment-a-masterstroke-in-tumor-therapeutics
#11
Himadri Patel, Pritish Nilendu, Devashree Jahagirdar, Jayanta K Pal, Nilesh Kumar Sharma
The microenvironment in which cancer resides plays an important role in regulating cancer survival, progression, malignancy and drug resistance. Tumor microenvironment (TME) consists of heterogeneous number and types of cellular and non-cellular components that vary in relation to tumor phenotype and genotype. In recent, non-cellular secreted components of microenvironmental heterogeneity have been suggested to contain various growth factors, cytokines, RNA, DNA, metabolites, structural matrix and matricellular proteins...
December 8, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29218747/patient-characteristics-and-outcome-measurement-in-a-low-secure-forensic-hospital
#12
Laura Longdon, Rachel Edworthy, Jeremy Resnick, Adrian Byrne, Martin Clarke, Natalie Cheung, Najat Khalifa
BACKGROUND: Health services are increasingly required to measure outcomes after treatment, which can be reported to the funding body and may be scrutinised by the public. Extensive high-quality measurements are time consuming. Routinely collected clinical data might, if anonymised, provide good enough evidence of useful change consequent on service received. RESEARCH QUESTION: Do the Health of the Nation Scale and the 20-item Historical, Clinical, Risk structured professional judgement tool scores provide evidence of clinical and risk change among low security hospital patients at 6 and 12 months after admission? METHODS: One hundred and eight men were either resident on the unit on 1 January 2011 or new admissions to the census date of 31 May 2013...
December 7, 2017: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/29218381/effectiveness-of-a-two-step-population-based-osteoporosis-screening-program-using-frax-the-randomized-risk-stratified-osteoporosis-strategy-evaluation-rose-study
#13
K H Rubin, M J Rothmann, T Holmberg, M Høiberg, S Möller, R Barkmann, C C Glüer, A P Hermann, M Bech, J Gram, K Brixen
The Risk-stratified Osteoporosis Strategy Evaluation (ROSE) study investigated the effectiveness of a two-step screening program for osteoporosis in women. We found no overall reduction in fractures from systematic screening compared to the current case-finding strategy. The group of moderate- to high-risk women, who accepted the invitation to DXA, seemed to benefit from the program. INTRODUCTION: The purpose of the ROSE study was to investigate the effectiveness of a two-step population-based osteoporosis screening program using the Fracture Risk Assessment Tool (FRAX) derived from a self-administered questionnaire to select women for DXA scan...
December 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29218307/calreticulin-challenges-posed-by-the-intrinsically-disordered-nature-of-calreticulin-to-the-study-of-its-function
#14
Lilian Varricchio, Mario Falchi, Massimiliano Dall'Ora, Caterina De Benedittis, Alessandra Ruggeri, Vladimir N Uversky, Anna Rita Migliaccio
Calreticulin is a Ca2+-binding chaperone protein, which resides mainly in the endoplasmic reticulum but also found in other cellular compartments including the plasma membrane. In addition to Ca2+, calreticulin binds and regulates almost all proteins and most of the mRNAs deciding their intracellular fate. The potential functions of calreticulin are so numerous that identification of all of them is becoming a nightmare. Still the recent discovery that patients affected by the Philadelphia-negative myeloproliferative disorders essential thrombocytemia or primary myelofibrosis not harboring JAK2 mutations carry instead calreticulin mutations disrupting its C-terminal domain has highlighted the clinical need to gain a deeper understanding of the biological activity of this protein...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29217671/positive-change-in-feedback-perceptions-and-behavior-a-10-year-follow-up-study
#15
Dorene F Balmer, Rebecca Tenney-Soeiro, Erika Mejia, Beth Rezet
BACKGROUND: Providing and learning from feedback are essential components of medical education, and typically described as resistant to change. But given a decade of change in the clinical context in which feedback occurs, the authors asked if, and how, perceptions of feedback and feedback behaviors might have changed in response to contextual affordances. METHODS: In 2017, the authors conducted a follow-up, ethnographic study on 2 general pediatric floors at the same children's hospital where another ethnographic study on a general pediatric floor was conducted in 2007...
December 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/29217525/integration-of-mobile-devices-to-facilitate-patient-care-and-teaching-during-family-centered-rounds
#16
Angela S Byrd, Pamela M McMahon, Richard J Vath, Michael Bolton, Melissa Roy
OBJECTIVES: The increasing prevalence of mobile devices in clinical settings has the potential to improve both patient care and education. The benefits are particularly promising in the context of family-centered rounds in inpatient pediatric settings. We aimed to increase mobile device usage by inpatient rounding teams by 50% in 6 months. We hoped to demonstrate that use of mobile devices would improve access to patient care and educational information and to determine if use would improve efficiency and perceptions of clinical teaching...
December 7, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29217416/identification-of-target-proteins-of-clinical-immunity-to-plasmodium-falciparum-in-a-region-of-low-malaria-transmission
#17
Hirokazu Sakamoto, Satoru Takeo, Eizo Takashima, Kazutoyo Miura, Bernard N Kanoi, Takamasa Kaneko, Eun-Taek Han, Mayumi Tachibana, Kazuhiro Matsuoka, Jetsumon Sattabongkot, Rachanee Udomsangpetch, Tomoko Ishino, Takafumi Tsuboi
The target molecules of antibodies against falciparum malaria remain largely unknown. Recently we have identified multiple proteins as targets of immunity against Plasmodium falciparum using African serum samples. To investigate whether potential targets of clinical immunity differ with transmission intensity, we assessed immune responses in residents of low malaria transmission region in Thailand. Malaria asymptomatic volunteers (Asy: n=19) and symptomatic patients (Sym: n=21) were enrolled into the study...
December 4, 2017: Parasitology International
https://www.readbyqxmd.com/read/29217337/health-literacy-and-outcomes-in-patients-with-heart-failure-a-prospective-community-study
#18
Matteo Fabbri, Kathleen Yost, Lila J Finney Rutten, Sheila M Manemann, Cynthia M Boyd, Daniel Jensen, Susan A Weston, Ruoxiang Jiang, Véronique L Roger
OBJECTIVE: To examine the impact of health literacy on hospitalizations and death in a population of patients with heart failure (HF). PATIENTS AND METHODS: Residents from the 11-county region in southeast Minnesota with a first-ever International Classification of Diseases, Ninth Revision code 428 or Tenth Revision code 150 (n=5121) from January 1, 2013, through December 31, 2015, were identified and prospectively surveyed to measure health literacy using established screening questions...
December 4, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29217156/air-q%C3%A2-versus-lma-fastrach%C3%A2-for-fiberoptic-guided-intubation-a-randomized-cross-over-manikin-trial
#19
M Portas, M I Canal, M Barrio, M Alonso, P Cabrerizo, M López-Gil, M Zaballos
INTRODUCTION: Airway management is still a major cause of anesthesia-associated morbidity and mortality. Supraglottic devices are recommended in difficult airway management guidelines. The aim of this study was to compare the performance of the Air-Q® and the LMA Fastrach™ for fiberoptic guided tracheal intubation. METHODS: Thirty-three anesthesia trainees participated in this randomized crossover study. Time to insert the dedicated airways (insertion of the airway into the manikin and delivery of two breaths), time to tracheal intubation (fiberoptic-guided tracheal intubation), time to remove the dedicated airway (removal of the Air-Q®/LMA Fastrach™ over the tracheal tube) and the opinion of the ease of use of the anesthesia trainees were measured...
December 4, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29217142/pharmacist-led-depression-screening-and-intervention-in-an-underserved-rural-and-multiethnic-diabetic-population
#20
Charlotte Wilson, Geoffrey Twigg
OBJECTIVES: To test the feasibility of implementation and integration of community pharmacist-led depression screening for patients with diabetes in an underserved rural area and to assess the response rate of prescribers to pharmacist-led depression screening and treatment recommendation. SETTING: Independent community pharmacy-run diabetes education center. PRACTICE DESCRIPTION: Clinical community pharmacy site on Maryland's Eastern Shore...
December 4, 2017: Journal of the American Pharmacists Association: JAPhA
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