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https://www.readbyqxmd.com/read/29454140/weight-management-in-rural-health-clinics-the-midwest-diet-and-exercise-trial
#1
Anna M Gorczyca, Richard A Washburn, Lauren Ptomey, Matthew S Mayo, Debra K Sullivan, Cheryl A Gibson, Robert Lee, Sarah Stolte, Joseph E Donnelly
Obesity prevalence is higher in rural compared to urban residents. Rural health clinics offer a potential venue for delivery of weight management. However, traditional programs require travel to attend on-site meetings which is impractical or inconvenient for rural residents. Clinic staff in most rural settings are unlikely to be trained to provide effective weight management. Remote delivery using group phone conferences (GP) or individual phone calls (IP), by staff associated with rural clinics eliminates the need for travel to attend on-site meetings...
February 14, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29453900/downregulation-of-reticulocalbin-1-differentially-facilitates-apoptosis-and-necroptosis-in-human-prostate-cancer-cells
#2
Xiaofei Liu, Nianzhao Zhang, Dawei Wang, Deyu Zhu, Quan Yuan, Xiulei Zhang, Lilin Qian, Huanmin Niu, Yi Lu, Guijie Ren, Keli Tian, Huiqing Yuan
Reticulocalbin 1 (RCN1), an endoplasmic reticulum (ER)-resident Ca 2+ -binding protein, is dysregulated in cancers, but its pathophysiological roles are largely unclear. Here, we demonstrate that RCN1 is overexpressed in clinical prostate cancer (PCa) samples, associated with Cyclin B, not Cyclin D1 expression, compared to that of benign tissues in a Chinese Han population. Downregulation of endogenous RCN1 significantly suppresses PCa cell viability and arrests the cell cycles of DU145 and LNCaP cells at the S and G2/M phases, respectively...
February 17, 2018: Cancer Science
https://www.readbyqxmd.com/read/29453670/incidence-and-drug-resistance-of-zoonotic-mycobacterium-bovis-infection-in-peshawar-pakistan
#3
Irfan Khattak, Muhammad Hassan Mushtaq, Sultan Ayaz, Sajid Ali, Anwar Sheed, Javed Muhammad, Muhammad Luqman Sohail, Haq Amanullah, Irshad Ahmad, Sadeeq Ur Rahman
Prevalence of zoonotic Mycobacterium bovis (bTB) disease in human population is underreported from the North of Pakistan. Here, we report on the proportion of human bTB disease among the overall TB patients, drug resistance pattern of bTB isolates, and knowledge, attitude, and practices (KAP)-based analysis of bTB disease. For this purpose, sputum samples from a total of 300 clinically diagnosed TB patients and 100 randomly selected school children suspected of pulmonary TB were processed by culture as well as polymerase chain reaction (PCR) for isolation, identification, and confirmation of Mycobacterium tuberculosis (mTB) and bTB species...
February 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29452720/evaluation-of-the-biological-activities-of-the-il-15-superagonist-complex-alt-803-following-intravenous-versus-subcutaneous-administration-in-murine-models
#4
Bai Liu, Monica Jones, Lin Kong, Terra Noel, Emily K Jeng, Sixiang Shi, Christopher G England, Sarah Alter, Jeffrey S Miller, Weibo Cai, Peter R Rhode, Hing C Wong
ALT-803 is a fusion protein complex consisting of an interleukin (IL)-15 superagonist and a dimeric IL-15 receptor alpha sushi domain IgG1 Fc fusion protein. When administered to mice, ALT-803 is capable of inducing natural killer (NK) and CD8 + T cell proliferation and activation, and effectively promoting potent anti-tumor responses. Currently, ALT-803 is in clinical trials for treatment of various solid tumors and hematological malignancies. In the initial phase of these clinical studies, intravenous (iv) injection was used according to the route used in pre-clinical efficacy studies...
February 13, 2018: Cytokine
https://www.readbyqxmd.com/read/29452587/timing-of-abortion-among-adolescent-and-young-women-presenting-for-post-abortion-care-in-kenya-a-cross-sectional-analysis-of-nationally-representative-data
#5
Boniface A Ushie, Chimaraoke O Izugbara, Michael M Mutua, Caroline W Kabiru
BACKGROUND: Complications of unsafe abortion are a leading cause of maternal mortality in sub-Saharan Africa. Adolescents and young women are disproportionately represented among those at risk of these complications. Currently, we know little about the factors associated with young women's timing of abortion. This study examined the timing of abortion as well as factors influencing it among adolescents and young women aged 12-24 years who sought post-abortion care (PAC) in health facilities in Kenya...
February 17, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29451862/neonatal-resuscitation-experience-curves-simulation-based-mastery-learning-booster-sessions-and-skill-decay-patterns-among-pediatric-residents
#6
Heideh H Matterson, Demian Szyld, Brad R Green, Heather B Howell, Martin V Pusic, Pradeep V Mally, Sean M Bailey
BACKGROUND: Following neonatal resuscitation program (NRP) training, decay in clinical skills can occur. Simulation-based deliberate practice (SBDP) has been shown to maintain NRP skills to a variable extent. Our study objectives were (a) to determine whether a single 30 min simulation-based intervention that incorporates SBDP and mastery learning (ML) can effectively restore skills and prevent skill decay and (b) to compare different timing options. METHODS: Following NRP certification, pediatric residents were randomly assigned to receive a video-recorded baseline assessment plus SBDP-ML refresher education at between 6 and 9 months (early) or between 9 and 12 months (late)...
February 16, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29450739/influence-of-operator-skill-level-on-the-clinical-outcome-of-non-surgical-periodontal-treatment-a-retrospective-study
#7
Avital Kozlovsky, Alex Rapaport, Zvi Artzi
OBJECTIVES: The aim of this study is to evaluate the effect of operators experience and skill on treatment results of initial non-surgical periodontal therapy. MATERIALS AND METHODS: Initial periodontal treatment was carried out by either second-year periodontal residents (PR) or last year dental students (DS). From the treatment records of patients in each group, plaque and bleeding indices, and pocket depth (PD) at baseline and at re-evaluation were collected retrospectively on each tooth at six locations...
February 15, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29449827/sun-exposure-across-the-life-course-significantly-modulates-early-multiple-sclerosis-clinical-course
#8
Steve Simpson, Ingrid van der Mei, Robyn M Lucas, Anne-Louise Ponsonby, Simon Broadley, Leigh Blizzard, Bruce Taylor
Background: Low vitamin D and/or sun exposure have been associated with increased risk of multiple sclerosis (MS) onset. However, comparatively, few studies have prospectively examined associations between these factors and clinical course. Objectives: To evaluate the association of sun exposure parameters and vitamin D levels with conversion to MS and relapse risk in a prospectively monitored cohort of 145 participants followed after a first demyelinating event up to 5-year review (AusLong Study)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29449723/an-outbreak-of-cutaneous-leishmaniasis-in-modena-province-northern-italy-report-of-35-cases
#9
A M Cesinaro, S Nosseir, E Mataca, M C Mengoli, C Cavatorta, W Gennari
Canine Leishmaniasis is a disease endemic in many parts of Europe, carried by insects of phlebotomous species. Humans are occasional hosts of the parasites. Cases of human leishmaniasis have been registered in Italy, particularly in the southern and coastal regions. In the period 1997-2016, we collected a series of 35 patients affected by cutaneous leishmaniasis, uncovered by skin biopsy and histological examination, 21 of them found in last 3 years. The patients, 28 males and 7 female, aged between 19 and 91, resided in a restricted area of Northern Italy, and none, but two, had travelled abroad...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29449351/regional-variation-and-predictors-of-over-registration-in-english-primary-care-in-2014-a-spatial-analysis
#10
Patrick Burch, Tim Doran, Evangelos Kontopantelis
BACKGROUND: There are more people registered with a general practice in England than are estimated to be resident in the country. The reasons behind this are not fully understood. We investigated the levels of over-registration (or under-registration) in English primary care, their regional variability and their association with population and geographical characteristics. METHODS: This was a cross-sectional study using mid-year population estimates for 2014 and general practice populations for the same year...
February 15, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29449163/orthopaedic-surgery-residency-rotations-and-correlation-with-orthopaedic-in-training-examination-performance
#11
Aaron I Karlen, Erik J Solberg, Deborah S Quanbeck, Ann E Van Heest
OBJECTIVE: The Orthopaedic In-Training Examination (OITE) is administered annually and is used to assess medical knowledge of orthopedic surgery residents. Beginning in the 2013 to 2014 academic year, the ACGME expanded the postgraduate year (PGY)-1 curriculum from 3 to 6 months of orthopedic surgery rotations. The purpose of this study is to evaluate the effect of increased PGY-1 orthopedic surgery exposure on medical knowledge as measured by the OITE. DESIGN: From 2011 to 2013, 24 PGY-2 residents completed 3 months of PGY-1 orthopedic training (Group 1)...
February 12, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29449162/is-video-based-education-an-effective-method-in-surgical-education-a-systematic-review
#12
Akgul Ahmet, Kus Gamze, Mustafaoglu Rustem, Karaborklu Argut Sezen
OBJECTIVE: Visual signs draw more attention during the learning process. Video is one of the most effective tool including a lot of visual cues. This systematic review set out to explore the influence of video in surgical education. We reviewed the current evidence for the video-based surgical education methods, discuss the advantages and disadvantages on the teaching of technical and nontechnical surgical skills. METHODS: This systematic review was conducted according to the guidelines defined in the preferred reporting items for systematic reviews and meta-analyses statement...
February 12, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29449157/risk-of-unplanned-caesarean-birth-in-vietnamese-born-women-in-victoria-australia-a-cross-sectional-study
#13
Paul A Agius, Mary-Ann Davey, Rhonda Small
BACKGROUND: Understanding the prevalence of, and factors associated with, caesarean birth among immigrant populations is essential for appropriate antenatal and postnatal resource allocation. AIMS: To compare rates of caesarean birth between one of the largest immigrant populations of women giving birth in Australia (Vietnamese-born women) with those of Australian-born women and investigate the odds of unplanned caesarean in these women, controlling for maternal characteristics, pregnancy complications and labour management factors...
February 12, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29449139/problems-with-access-to-dental-treatment-for-children-with-epilepsy
#14
Maria Mielnik-Błaszczak, Agnieszka Skawińska-Bednarczyk, Artur Michałowski, Jerzy Błaszczak
INTRODUCTION: Epilepsy is a common medical disorder and due to a variety of barriers, people with epilepsy may not have access to needed healthcare services, particularly based on their place of residence. OBJECTIVES: The aim of the study was to assess access to dental treatment in children and adolescents with epilepsy in Lublin Voivodeship. MATERIAL AND METHODS: Clinical and questionnaire examinations were performed in 107 children and young people, of both sexes, in the ages between 6 and 18years old from the Lublin macroregion...
February 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29447650/characteristics-of-research-tracks-in-dermatology-residency-programs-a-national-survey
#15
Saisindhu Narala, Tiffany Loh, Kanade Shinkai, Taraneh Paravar
Pursuing research is encouraged in dermatology residency programs. Some programs offer specific research or investigative tracks. Currently, there is little data on the structure or scope of research tracks in dermatology residency programs. An anonymous online survey was distributed to the Association of Professors of Dermatology listserve in 2016. Program directors of dermatology residency programs in the United States were asked to participate and 38 of the 95 program directors responded. The survey results confirmed that a 2+2 research track, which is two years of clinical training followed by two years of research, was the most common investigator trackmodel and may promote an academic career at the resident's home institution...
December 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447614/adherence-and-perceived-barriers-to-oral-antiviral-therapy-for-chronic-hepatitis-b
#16
Kerui Xu, Li-Ming Liu, Paraskevi A Farazi, Hongmei Wang, Fedja A Rochling, Shinobu Watanabe-Galloway, Jian-Jun Zhang
BACKGROUND: Globally, of the 248 million people chronically infected with the hepatitis B virus (HBV), 74 million reside in China. Five oral nucleot(s)ide analogs (NUCs) have been approved for the treatment of chronic hepatitis B (CHB) in China. OBJECTIVES: The aims of this study were to determine rates of adherence to NUC therapy in patients with CHB, to identify the self-perceived barriers to adherence, and to examine the factors associated with adherence. METHODS: Questionnaire-based interviews were administered among Chinese patients with CHB at hepatology clinics of a tertiary hospital in the city of Wuhan, China...
2018: Global Health Action
https://www.readbyqxmd.com/read/29447544/-asking-but-not-screening-assessing-physicians-and-nurses-substance-related-clinical-behaviors
#17
Jon Agley, Joan M Carlson, Angela M McNelis, Ruth A Gassman, Rhonda Schwindt, David Crabb, Julie Vannerson
BACKGROUND: Screening, brief intervention, and referral to treatment (SBIRT) is a promising public health approach for problematic substance use. A core component of SBIRT is the use of formal screening tools to categorize a patient's likely level of risk in order to provide an appropriately-matched service. Training in formal screening is included in many SBIRT training programs, but infrequently is emphasized. OBJECTIVES: To assess pre-training levels of SBIRT-related clinical behaviors, including screening, this study examined a secondary dataset collected from internal medicine residents and graduate nurse practitioner students...
February 15, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29447405/the-representation-of-vulnerable-populations-in-quality-improvement-studies
#18
Asaph Rolnitsky, Maksim Kirtsman, Hanna R Goldberg, Michael Dunn, Chaim M Bell
Purpose: A mapping review to quantify representation of vulnerable populations, who suffer from disparity and often inequitable healthcare, in quality improvement (QI) research. Data sources: Studies published in 2004-2014 inclusive from Medline, Embase and Cochrane databases for English language research with the terms 'quality improvement' or 'quality control' or 'QI' and 'plan-do-study-act' or 'PDSA' in the years 2004-2014 inclusively. Study selection: Published clinical research that was a QI-themed, as identified by its declared search terms, MESH terms, abstract or title...
February 13, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29446155/not-just-trust-factors-influencing-learners-attempts-to-perform-technical-skills-on-real-patients
#19
Susan L Bannister, Mark S Dolson, Lorelei Lingard, David A Keegan
CONTEXT: As part of their training, physicians are required to learn how to perform technical skills on patients. The previous literature reveals that this learning is complex and that many opportunities to perform these skills are not converted into attempts to do so by learners. This study sought to explore and understand this phenomenon better. METHODS: A multi-phased qualitative study including ethnographic observations, interviews and focus groups was conducted to explore the factors that influence technical skill learning...
February 15, 2018: Medical Education
https://www.readbyqxmd.com/read/29445028/evaluation-of-treatment-patterns-and-survival-outcomes-in-elderly-pancreatic-cancer-patients-a-surveillance-epidemiology-and-end-results-medicare-analysis
#20
Walid L Shaib, Jeb S Jones, Michael Goodman, Juan M Sarmiento, Shishir K Maithel, Kenneth Cardona, Sujata Kane, Christina Wu, Olatunji B Alese, Bassel F El-Rayes
BACKGROUND: Management of pancreatic cancer (PC) in elderly patients is unknown; clinical trials exclude patients with comorbidities and those of extreme age. This study evaluated treatment patterns and survival outcomes in elderly PC patients using linked Surveillance, Epidemiology, and End Results (SEER) and Medicare data. MATERIALS AND METHODS: Histology codes 8140, 8500, 8010, 8560, 8490, 8000, 8260, 8255, 8261, 8263, 8020, 8050, 8141, 8144, 8210, 8211, or 8262 in Medicare Parts A and B were identified...
February 14, 2018: Oncologist
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