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https://www.readbyqxmd.com/read/28228000/c60-fullerene-as-promising-therapeutic-agent-for-the-prevention-and-correction-of-skeletal-muscle-functioning-at-ischemic-injury
#1
D M Nozdrenko, D O Zavodovskyi, T Yu Matvienko, S Yu Zay, K I Bogutska, Yu I Prylutskyy, U Ritter, P Scharff
The therapeutic effect of pristine C60 fullerene aqueous colloid solution (C60FAS) on the functioning of the rat soleus muscle at ischemic injury depending on the time of the general pathogenesis of muscular system and method of administration C60FAS in vivo was investigated. It was found that intravenous administration of C60FAS is the optimal for correction of speed macroparameters of contraction for ischemic muscle damage. At the same time, intramuscular administration of C60FAS shows pronounced protective effect in movements associated with the generation of maximum force responses or prolonged contractions, which increase the muscle fatigue level...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28227332/using-surface-electromyography-to-detect-changes-in-innervation-zones-pattern-after-human-cervical-spinal-cord-injury
#2
Babak Afsharipour, Milap S Sandhu, Ghulam Rasool, Nina L Suresh, William Z Rymer, Babak Afsharipour, Milap S Sandhu, Ghulam Rasool, Nina L Suresh, William Z Rymer, Milap S Sandhu, Babak Afsharipour, William Z Rymer, Nina L Suresh, Ghulam Rasool
Human spinal cord injuries (SCI) disrupt the pathways between brain and spinal cord, resulting in substantial impairment and loss of function. Currently, we do not have the ability to precisely quantify the "functional" level of motor injury. The aim of this study is to determine if high-density surface electromyography imaging (SEI) can be used to characterize the location and extent of the spinal lesion. SEI is a safe and non-invasive technique, which uses several electrodes to provide a map of muscle activity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226835/analysis-of-muscle-synergy-for-evaluation-of-task-specific-performance-in-stroke-patients
#3
Si Li, Cheng Zhuang, Xiao Zhang, Chuanxin M Niu, Qing Xie, Ning Lan, Si Li, Cheng Zhuang, Xiao Zhang, Chuanxin M Niu, Qing Xie, Ning Lan, Chuanxin M Niu, Xiao Zhang, Cheng Zhuang, Si Li, Ning Lan, Qing Xie
Muscle synergy represents a central neural module that organizes and activates a group of muscles when performing a certain task. However, whether muscle synergy is a good physiological indicator of motor ability in task performance for patients suffering stroke is not clear. The purpose of this study is to understand how information of task-specific muscle synergy in healthy subjects and patients post stroke can be used to evaluate their motor ability, and further to assist motor rehabilitation for stroke patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225648/safety-of-autologous-human-schwann-cell-transplantation-in-subacute-thoracic-spinal-cord-injury
#4
Kimberly D Anderson, James Guest, W Dalton Dietrich, Mary B Bunge, Rosie Curiel, Marine Dididze, Barth A Green, Aisha Khan, Damien D Pearse, Efrat Saraf-Lavi, Eva Widerstrom-Noga, Pat Wood, Allan D Levi
The rationale for implantation of autologous human Schwann cells (SCs) in people with subacute spinal cord injury (SCI) is based on evidence that transplanted SCs are neuroprotective, support local axonal plasticity, and are capable of myelinating axons. A Phase I clinical trial was conducted to evaluate the safety of autologous human SC transplantation into the injury epicenter of six subjects with subacute SCI. The trial was an open-label, unblinded, non-randomized, non-placebo controlled study with a dose escalation design and standard medical rehabilitation...
February 18, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28224701/pathogenic-role-of-anti-srp-and-anti-hmgcr-antibodies-in-necrotizing-myopathies-myofiber-atrophy-and-impairment-of-muscle-regeneration-in-necrotizing-autoimmune-myopathies
#5
Louiza Arouche-Delaperche, Yves Allenbach, Damien Amelin, Corinna Preusse, Vincent Mouly, Wladimir Mauhin, Gaelle Dzangue Tchoupou, Laurent Drouot, Olivier Boyer, Werner Stenzel, Gillian Butler-Browne, Olivier Benveniste
OBJECTIVE: Immune mediated necrotizing myopathies (IMNM) may be associated with either anti-SRP or anti-HMGCR antibodies (Abs) and the titer of these Abs is correlated with the disease activity. We investigated if anti-SRP and anti-HMGCR Abs could be involved in muscle damages. METHODS: Muscle biopsies of patients were analyzed for atrophy and regeneration, by measuring the fibers size and by performing immunostaining of neonatal myosin heavy chain. To further understand the role of the Abs in the pathology, we performed muscle cell co-culture with the Abs...
February 22, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28224232/effects-of-traumeel-tr14-on-recovery-and-inflammatory-immune-response-after-repeated-bouts-of-exercise-a-double-blind-rct
#6
Kerstin Muders, Christian Pilat, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Frank-Christoph Mooren
PURPOSE: The purpose of this double-blind, randomized, placebo-controlled clinical trial was to investigate the effects of the natural combination medicine Traumeel (Tr14) consisting of 14 diluted biological and mineral components on the inflammatory immune response and recovery up to 72 h after repetitive bouts of bicycle tests. METHODS: Antigen-stimulated IL-1ra and IL-6 were defined as primary outcome measures. Moreover, various immunological and serum muscle damage markers were investigated...
February 21, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28223398/exertional-dyspnoea-in-interstitial-lung-diseases-the-clinical-utility-of-cardiopulmonary-exercise-testing
#7
Matteo Bonini, Giuseppe Fiorenzano
Interstitial lung diseases (ILDs) represent a heterogeneous group of pathologies characterised by alveolar and interstitial damage, pulmonary inflammation (usually associated with fibrosis), decreased lung function and impaired gas exchange, which can be attributed to either a known or an unknown aetiology. Dyspnoea is one of the most common and disabling symptoms in patients with ILD, significantly impacting quality of life. The mechanisms causing dyspnoea are complex and not yet fully understood. However, it is recognised that dyspnoea occurs when there is an imbalance between the central respiratory efferent drive and the response of the respiratory musculature...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28223253/development-and-characterization-of-mouse-monoclonal-antibodies-reactive-with-chicken-cxcli2
#8
Woo H Kim, Hyun S Lillehoj, Yeasul Lim, Wongi Min, Yvonne B Sullivan, Laura Kakach, Joanna W LaBresh
Interleukin-8(IL-8)/CXCL8 is a CXC-family chemokine attracts lymphocytes to sites of tissue damage and plays a role in the inflammatory response and wound healing. Chicken chemotactic and angiogenic factor was referred to as chCXCLi2 and has been studied as one of human CXCL8 homologue for more than 20 years. However, no monoclonal antibodies (mAbs) that specifically detect chCXCLi2 have been developed. Here, we developed and characterized mouse mAbs against chCXCLi2 to define its immunological properties. Two mouse mAbs against chCXCLi2 were generated and confirmed to display specific binding with not only recombinants, but endogenous chCXCLi2 by Western blot analysis, ELISA, and immunocytochemistry...
February 18, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28223230/myotoxicity-of-statins-mechanism-of-action
#9
REVIEW
Patrick du Souich, Ghislaine Roederer, Robert Dufour
Statins are effective drugs to reduce cardiovascular events secondary to dyslipidemia; however, they cause frequent undesirable side effects. The incidence of statin-induced myotoxicity (SIM) is presented by 7 to 29% of patients, depending upon the report. SIM may develop in presence of abnormally high concentrations of statins in the myocyte and/or in presence of muscular conditions that may predispose to SIM. High concentrations of statins in the myocyte may occur whenever the activity of liver influx membrane transporters, namely OATP1B1, of drug metabolizing enzymes, and of liver and muscular efflux transporters, MDR1 and BCRP, is reduced...
February 13, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28223068/parasite-control-and-skeletal-myositis-in-trypanosoma-cruzi-infected-and-exercised-rats
#10
Rômulo D Novaes, Reggiani V Gonçalves, Arlete R Penitente, Marli C Cupertino, Izabel R S C Maldonado, André Talvani, Antônio J Natali
Non-pharmacological strategies have been rarely described in the treatment of infectious diseases. Although exercise training has been recently incorporated in the clinical management of Chagas disease, the rationale basis that supports this indication is poorly understood. Thus, we investigated the effect of an aerobic exercise on the parasitism, inflammation and oxidative tissue damage in a murine model of Trypanosoma cruzi-induced skeletal myositis. Wistar rats were randomized into four groups: trained not infected (TNI) and infected (TI), sedentary not infected (SNI) and infected (SI)...
February 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28222581/a-comparison-of-the-physiological-demands-imposed-by-competing-in-a-half-marathon-vs-a-marathon
#11
Juan Del Coso, Juan J Salinero, Beatriz Lara, Javier Abián-Vicén, César Gallo-Salazar, Francisco Areces
BACKGROUND: While there is widespread scientific information about the physiological challenges imposed on elite endurance runners during competitions, the information regarding the amateur population is scarce. The aim of this study was to compare the physical and physiological load imposed by competing in a real half-marathon vs a marathon race. METHODS: From a larger group of participants, we selected 22 experienced runners who were matched in pairs (11 marathoners and 11 half-marathoners) for age and anthropometric data...
February 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28222580/acute-and-delayed-responses-of-steroidal-hormones-blood-lactate-and-biomarkers-of-muscle-damage-after-a-resistance-training-session-time-of-day-effects
#12
Achraf Ammar, Hamdi Chtourou, Mouna Turki, Omar Hammouda, Ahmed Chaari, Mariem Boudaya, Tarak Driss, Fatma Ayedi, Nizar Souissi
BACKGROUND: The present study aimed to investigate the effect of time-of-days (TOD) on some biochemical and hormonal responses after resistance training sessions. METHODS: Ten trained subjects (22±2 years) performed, in randomized order, three resistance-training-sessions at 07h:00, 13h:00 and 17h:00. Each training-session included six upper and lower body resistance exercises with 3×10 repetitions. Blood lactate (Lac), creatine kinase (CK), lactate dehydrogenase (LDH), cortisol (C) and testosterone (T) were collected at rest, 3min and 48h after each-session...
February 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28222366/alterations-of-tissue-metallothionein-and-vitellogenin-concentrations-in-tropical-cup-oysters-saccostrea-sp-following-short-term-96h-exposure-to-cadmium
#13
Angela M Moncaleano-Niño, Sergio A Barrios-Latorre, Javier F Poloche-Hernández, Vanessa Becquet, Valérie Huet, Luisa Villamil, Hélène Thomas-Guyon, Michael J Ahrens, Andrea Luna-Acosta
Metallothioneins and vitellogenins are low molecular weight proteins that have been used widely in environmental monitoring as biomarkers of exposure and damage to metals and estrogenic compounds, respectively. In the present study, the responses of metallothionein and vitellogenin tissue concentrations were measured following acute (96h) aqueous exposures to cadmium in Saccostrea sp., a tropical cup oyster native to the Western Pacific Ocean that has recently established itself in the Caribbean Sea. Adult oysters (1...
February 9, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28220067/shared-and-task-specific-muscle-synergies-during-normal-walking-and-slipping
#14
Mohammad Moein Nazifi, Han Ul Yoon, Kurt Beschorner, Pilwon Hur
Falling accidents are costly due to their prevalence in the workplace. Slipping has been known to be the main cause of falling. Understanding the motor response used to regain balance after slipping is crucial to developing intervention strategies for effective recovery. Interestingly, studies on spinalized animals and studies on animals subjected to electrical microstimulation have provided major evidence that the Central Nervous System (CNS) uses motor primitives, such as muscle synergies, to control motor tasks...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28218814/mr-elastography-measurement-of-the-effect-of-passive-warmup-prior-to-eccentric-exercise-on-thigh-muscle-mechanical-properties
#15
Paul Kennedy, Lewis J Macgregor, Eric Barnhill, Curtis L Johnson, Michael Perrins, Angus Hunter, Colin Brown, Edwin J R van Beek, Neil Roberts
PURPOSE: To investigate the effect of warmup by application of the thermal agent Deep Heat (DH) on muscle mechanical properties using magnetic resonance elastography (MRE) at 3T before and after exercise-induced muscle damage (EIMD). MATERIALS AND METHODS: Twenty male participants performed an individualized protocol designed to induce EIMD in the quadriceps. DH was applied to the thigh in 50% of the participants before exercise. MRE, T2 -weighted MRI, maximal voluntary contraction (MVC), creatine kinase (CK) concentration, and muscle soreness were measured before and after the protocol to assess EIMD effects...
February 20, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28218619/muscular-dystrophy-meets-protein-biochemistry-the-mother-of-invention
#16
Steven D Funk, Jeffrey H Miner
Muscular dystrophies result from a defect in the linkage between the muscle fiber cytoskeleton and the basement membrane (BM). Congenital muscular dystrophy type MDC1A is caused by mutations in laminin α2 that either reduce its expression or impair its ability to polymerize within the muscle fiber BM. Defects in this BM lead to muscle fiber damage from the force of contraction. In this issue of the JCI, McKee and colleagues use a laminin polymerization-competent, designer chimeric BM protein in vivo to restore function of a polymerization-defective laminin, leading to normalized muscle structure and strength in a mouse model of MDC1A...
February 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28217804/-changes-of-perimysial-junctional-plates-induced-by-excessive-eccentric%C3%A2-training-and-the-effects-of-acupuncture-intervention
#17
Mei Kong, Xiang Zhang, Mei-Ling Ye, Xue-Lin Zhang
This study aimed to investigate the effects of acupuncture intervention on excessive eccentric training-induced changes of perimysial junctional plates (PJPs) domain. Thirty healthy male Wistar rats were randomly assigned to 5 groups: control group, four-week training group, four-week training + 1-week recovery group and four-week training + 1-week acupuncture group. Rats were subjected to continuous excessive eccentric training for 4 weeks (incline -16°, speed 16-20 m/min, 60-90 min/d, 5 day per week), and then were subjected to one-week spontaneous recovery or one-week recovery with acupuncture intervention (a piece of filiform needle for 4 min every day)...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28217661/winged-scapula-caused-by-rhomboid-paralysis-a-case-report
#18
Maria Grazia Benedetti, Alessandro Zati, Silvia Bonfiglioli Stagni, Isabella Fusaro, Roberta Monesi, Roberto Rotini
Scapular winging secondary to dorsal scapular nerve (DSN) damage is an underestimated condition. It is often caused by entrapment of the nerve due to a hypertrophic middle scalene muscle, or by stretching of the DSN during traumatic movements. The condition has also been attributed to myofascial pain syndrome of the rhomboids with entrapment of the DSN. The non-specific symptomatology reported by patients is often incorrectly diagnosed, and this can result in a high level of disability of the upper limb. A clinical case of misdiagnosed dorsal scapula entrapment is presented...
October 2016: Joints
https://www.readbyqxmd.com/read/28215813/a-comparative-approach-using-biomarkers-in-feral-and-caged-neotropical-fish-implications-for-biomonitoring-freshwater-ecosystems-in-agricultural-areas
#19
Carlos Eduardo Delfino Vieira, Patrícia Gomes Costa, Liziara Costa Cabrera, Ednei Gilberto Primel, Gilberto Fillmann, Adalto Bianchini, Claudia Bueno Dos Reis Martinez
The aim of this study was to investigate the responses of biomarkers in feral and caged fish and the capacity of these biomarkers to discriminate contamination levels along a stream located in an agricultural area in Southern Brazil. Specimens of the Neotropical fish, Astyanax altiparanae, were confined for 168h in three lakes along the stream. Additionally, during the weeks of in situ exposure, wild specimens of this species were collected from the same sites. Biochemical biomarkers were analyzed, such as phase I biotransformation enzyme 7-ethoxyresorufin-O-deethylase (EROD) and phase II biotransformation enzyme glutathione S-transferase, and we also determined hepatic and branchial levels of non-protein thiols (NPSH), oxidative damage such as lipid peroxidation (LPO), and acetylcholinesterase (AChE) activity in muscle and brain...
February 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28214734/developmental-toxicity-and-molecular-responses-of-marine-medaka-oryzias-melastigma-embryos-to-ciguatoxin-p-ctx-1-exposure
#20
Meng Yan, Priscilla T Y Leung, Jack C H Ip, Jin-Ping Cheng, Jia-Jun Wu, Jia-Rui Gu, Paul K S Lam
Ciguatoxins are produced by toxic benthic dinoflagellates and cause ciguatera fish poisoning worldwide, but the toxic effects on developing marine fish have not been well investigated. The Pacific ciguatoxin (P-CTX-1), is a potent sodium channel agonist, which is one of the most toxic members among all CTXs. This study evaluated the toxic effects of microinjecting purified Pacific ciguatoxin-1 (P-CTX-1) on embryonic development of marine medaka Oryzias melastigma. A lower 96h-LD50 value was estimated for eleuthero-embryos (1...
February 10, 2017: Aquatic Toxicology
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