keyword
MENU ▼
Read by QxMD icon Read
search

7 keto

keyword
https://www.readbyqxmd.com/read/28511808/astaxanthin-from-shrimp-efficiently-modulates-oxidative-stress-and-allied-cell-death-progression-in-mcf-7-cells-treated-synergistically-with-%C3%AE-carotene-and-lutein-from-greens
#1
Poorigali Raghavendra-Rao Sowmya, Bangalore Prabhashankar Arathi, Kariyappa Vijay, Vallikannan Baskaran, Rangaswamy Lakshminarayana
This study investigated the synergistic efficacy of keto-carotenoid astaxanthin (AST, from shrimp) plus hydrocarbon (β-carotene, BC) and hydroxyl (lutein, L) carotenoids (from greens) on molecular events in MCF-7 cells. MCF-7 cells were treated with either of carotenoid (20 μM, AST or BC or L) separately or the mixture of them (an equimolar concentration of carotenoids mixture, CM) or saponified carotenoid extract from shrimp (SSCE) for 48 h and analyzed cellular uptake, cytotoxicity, and apoptosis. The IC50 and combination-index values of AST co-treatment with a lower concentration of BC and L (5 μM) exhibited enhanced cytotoxicity and oxidative stress as compared with individual carotenoids or SSCE...
May 13, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28474360/anchimeric-assisted-spontaneous-hydrolysis-of-cyanohydrins-under-ambient-conditions-implications-for-cyanide-initiated-selective-transformations
#2
Jayasudhan Reddy Yerabolu, Charles L Liotta, Ramanarayanan Krishnamurthy
Nitrile/cyanide hydrolysis is of importance from the perspective of organic chemistry, especially, prebiotic chemistry. Herein we report that cyanohydrins, generated by the reaction of cyanide with -keto acids and -keto-alcohols, spontaneously hydrolyze under ambient conditions (aqueous medium, r.t. and a range of pH). The spontaneous hydrolysis is effected by an intramolecular-proton transfer and an intramolecular 5-exo-dig attack, but with a twist. In the case of β-keto acids, the hydrolysis is mediated by the neighboring carboxylic acid group only at pH values less than 7, while in the case of -keto-alcohols the hydrolysis is mediated by the neighboring hydroxyl group only at pH values greater than 7...
May 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28465708/rs5911-and-rs3842788-genetic-polymorphism-blood-stasis-syndrome-and-plasma-txb2-and-hs-crp-levels-are-associated-with-aspirin-resistance-in-chinese-chronic-stable-angina-patients
#3
Mei Xue, Xuesong Yang, Lin Yang, Na Kou, Yu Miao, Mingming Wang, Junhua Ren, Quanli Zhao
The identification of single nucleotide polymorphisms (SNPs) related to aspirin resistance (AR) is of great significance for the explanation why some individuals demonstrate an incomplete response to aspirin and for optimizing the antiplatelet therapy strategy. The study was designed to investigate the possible associated genetic markers and clinical factors of AR for Chinese patients with chronic stable angina after PCI and to analyze the association between TXA2, PGI2, hs-CRP level, AR, and gene polymorphisms...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28453264/polymorphous-al-mofs-based-on-v-shaped-linker-molecules-synthesis-properties-and-in-situ-investigation-of-their-crystallization
#4
Martin Krüger, A Ken Inge, Helge Reinsch, Yuan-Han Li, Mohammad Wahiduzzaman, Chia-Her Lin, Sue-Lein Wang, Guillaume Maurin, Norbert Stock
The in situ and systematic high-throughput investigation of the system Al(3+)/4,4'-benzophenonedicarboxylic acid (H2BPDC)/DMF/H2O in the presence of various additives was carried out, and a new Al-MOF of composition [Al(OH)(BPDC)], denoted as CAU-21-BPDC, was obtained. Its crystal structure was determined from single-crystal X-ray diffraction data (space group I422, a = b = 17.2528(7) Å, c = 23.864(1) Å). The structure is built up by octanuclear rings of cis corner-sharing AlO6 polyhedra forming the inorganic building unit (IBU)...
April 28, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28431863/the-myometrial-contractility-during-late-pregnancy-in-dairy-cows-in-vitro
#5
L Górriz-Martín, S E Ulbrich, M Schmicke, G Hirsbrunner, C Keller, N Yücesoy, C Pfarrer, H Bollwein, M Heppelmann
This study aimed to investigate the in vitro contractility of the myometrium and its relationship to the blood concentrations of estradiol-17β (E2β), progesterone (P4), 15-keto-13,14-dihydro-PGF2α (PGFM) and ionised calcium (Ca(2+)) prior to tissue harvest in 12 healthy Holstein-Friesian cows in late pregnancy. Three circular (CM) and 3 longitudinal myometrial (LM) strips were dissected during a caesarean section and mounted in an organ bath containing modified Krebs solution (KS). The spontaneous contractility was recorded during five 30-min time periods (T1 to T5), after which the strips were exposed to increasing concentrations of oxytocin (OT; 10(-10)-10(-7)M), a natural PGF2α-analogue (PGF; 10(-7)-10(-4)M) and KS (Cont) for four 30-min time periods (T6 to T9)...
April 7, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28422067/synthesis-characterization-antimicrobial-and-antiproliferative-activity-evaluation-of-cu-ii-co-ii-zn-ii-ni-ii-and-pt-ii-complexes-with-isoniazid-derived-compound
#6
Elena Pahonțu, Diana-Carolina Ilieș, Sergiu Shova, Camelia Oprean, Virgil Păunescu, Octavian Tudorel Olaru, Flavian Ștefan Rădulescu, Aurelian Gulea, Tudor Roșu, Doina Drăgănescu
Hydrazone complexes of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) with N-isonicotinoyl-N'-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as IR (infrared), ¹H-NMR and (13)C-NMR (hydrogen and carbon nuclear magnetic resonance, UV-Vis (ultraviolet-visible), FAB (fast atom bombardment), EPR (electron paramagnetic resonance), and mass spectroscopies...
April 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28420137/modification-of-the-mycotoxin-deoxynivalenol-using-microorganisms-isolated-from-environmental-samples
#7
Nina M Wilson, Nicole McMaster, Dash Gantulga, Cara Soyars, Susan P McCormick, Ken Knott, Ryan S Senger, David G Schmale
The trichothecene mycotoxin deoxynivalenol (DON) is a common contaminant of wheat, barley, and maize. New strategies are needed to reduce or eliminate DON in feed and food products. Microorganisms from plant and soil samples collected in Blacksburg, VA, USA, were screened by incubation in a mineral salt media containing 100 μg/mL DON and analysis by gas chromatography mass spectrometry (GC/MS). Two mixed cultures derived from soil samples consistently decreased DON levels in assays using DON as the sole carbon source...
April 15, 2017: Toxins
https://www.readbyqxmd.com/read/28402270/akr1b10-promotes-breast-cancer-cell-migration-and-invasion-via-activation-of-erk-signaling
#8
Jia Li, Yuanwei Guo, Lili Duan, Xinglin Hu, Xi Zhang, Jian Hu, Li Huang, Rongzhang He, Zheng Hu, Weihao Luo, Tan Tan, Renbin Huang, Duanfang Liao, Yuan-Shan Zhu, Di-Xian Luo
BACKGROUND: Aldo-keto reductase family 1, member B10 (AKR1B10), is known to be significantly induced in the cells of various cancers such as breast cancer. However, the mechanisms of AKR1B10 promoting tumorigenesis in breast cancer remain unclear. In the present study, we demonstrated the potential role and mechanism of AKR1B10 in the invasion and migration of breast cancer cells. METHODS: The expression level of AKR1B10 in breast carcinoma, para-carcinoma and cancer tissues were detected by immunohistochemical evaluation and real-time polymerase chain reaction (RT-PCR), and the correlationships between AKR1B10 expression and clinicopathological features in breast cancer patients (n=131) were investigated...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28391714/isolation-and-x-ray-structure-analysis-of-citreohybridonol-from-marine-derived-penicillium-atrovenetum
#9
Ferhat Can Özkaya, Weaam Ebrahim, Maximilian Klopotowski, Zhen Liu, Christoph Janiak, Peter Proksch
The anti-neuroinflammatory meroterpenoid citreohybridonol was isolated for the first time from a sponge-derived fungus Penicillium atrovenetum. In this study, in addition to isolation and structure featuring, its unambiguous absolute configuration was determined exclusively by single crystal X-ray diffraction. The C-17-keto tautomer was clearly observed in X-ray analysis. The substance crystallises in the monoclinic space group P21 with a = 10.7496(5) Å, b = 14.3286(7) Å, c = 17.4909(8) Å, β = 103...
April 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28388357/quercetin-inhibits-advanced-glycation-end-product-formation-via-chelating-metal-ions-trapping-methylglyoxal-and-trapping-reactive-oxygen-species
#10
Mohammad Nazrul Islam Bhuiyan, Shinya Mitsuhashi, Kengo Sigetomi, Makoto Ubukata
Physiological concentration of Mg(2+), Cu(2+), and Zn(2+) accelerated AGE formation only in glucose-mediated conditions, which was effectively inhibited by chelating ligands. Only quercetin (10) inhibited MGO-mediated AGE formation as well as glucose- and ribose-mediated AGE formation among 10 polyphenols (1-10) tested. We performed an additional structure-activity relationship (SAR) study on flavanols (10, 11, 12, 13, and 14). Morin (12) and kaempherol (14) showed inhibitory activity against MGO-mediated AGE formation, whereas rutin (11) and fisetin (13) did not...
May 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28379296/relaxin-treatment-reduces-angiotensin-ii-induced-vasoconstriction-in-pregnancy-and-protects-against-endothelial-dysfunction%C3%A2
#11
Sarah A Marshall, Chen Huei Leo, Jane E Girling, Marianne Tare, Sally Beard, Natalie J Hannan, Laura J Parry
The peptide relaxin has gained considerable attention as a new vasoactive drug, largely through its beneficial therapeutic effects in cardiovascular disease. In this study, we tested the hypothesis that relaxin treatment alleviates systemic vascular dysfunction characteristic of hypertensive diseases of pregnancy. We investigated vascular effects and mechanisms of relaxin action in (i) pregnant relaxin-deficient (Rln-/-) mice with enhanced responses to angiotensin II (AngII) and (ii) arteries pre-incubated ex vivo in trophoblast conditioned media (TCM) to induce endothelial dysfunction...
April 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28366530/synthesis-of-camphecene-derivatives-using-click-chemistry-methodology-and-study-of-their-antiviral-activity
#12
Oleg I Artyushin, Elena V Sharova, Natalya M Vinogradova, Galina K Genkina, Aleksandra A Moiseeva, Zinaida S Klemenkova, Iana R Orshanskaya, Anna A Shtro, Renata A Kadyrova, Vladimir V Zarubaev, Olga I Yarovaya, Nariman F Salakhutdinov, Valery K Brel
A series of seventeen tetrazole derivatives of 1,7,7-trimethyl-[2.2.1]bicycloheptane were synthesized using click chemistry methodology and characterized by spectral data. Studies of cytotoxicity and in vitro antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1) in MDCK cells of the compounds obtained were performed. The structure-activity relationship analysis suggests that to possess virus-inhibiting activity, the compounds of this group should bear oxygen atom with a short linker (C2-C4), either as a hydroxyl group (18, 19, 29), keto-group (21) or as a part of a heterocycle (24)...
March 22, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28356936/danshensu-a-major-water-soluble-component-of-salvia-miltiorrhiza-enhances-the-radioresponse-for-lewis-lung-carcinoma-xenografts-in-mice
#13
Hong-Ying Cao, Rui-Lin Ding, Meng Li, Mao-Nan Yang, Ling-Lin Yang, Jing-Bo Wu, Bo Yang, Jing Wang, Cui-Lian Luo, Qing-Lian Wen
The molecule 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid (danshensu), a herbal preparation used in traditional Chinese medicine, has been found to possess potential antitumor and anti-angiogenesis effects. The aim of the present study was to investigate the efficacy of the combination of radiation therapy (RT) with danshensu in the treatment of Lewis lung carcinoma (LLC) xenografts, whilst exploring and evaluating the mechanism involved. In total, 8-week old female C57BL/6J mice were randomly assigned into 3 groups to receive: RT, RT + cisplatin and RT + danshensu, respectively, when LLC reached 100-150 mm(3)...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28351628/coupling-of-gas-chromatography-and-electrospray-ionization-high-resolution-mass-spectrometry-for-the-analysis-of-anabolic-steroids-as-trimethylsilyl-derivatives-in-human-urine
#14
Eunju Cha, Eun Sook Jeong, Sangwon Cha, Jaeick Lee
In this study, gas chromatography (GC) was interfaced with high resolution mass spectrometry (HRMS) with electrospray ionization source (ESI) and the relevant parameters were investigated to enhance the ionization efficiency. In GC-ESI, the distances (x-, y- and z) and angle between the ESI needle, GC capillary column and MS orifice were set to 7 (x-distance), 4 (y-distance), and 1 mm (z-distance). The ESI spray solvent, acid modifier and nebulizer gas flow were methanol, 0.1% formic acid and 5 arbitrary units, respectively...
April 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28347298/erratum-to-local-intra-uterine-ang-1-7-infusion-attenuates-pge2-and-6-keto-pgf1%C3%AE-in-decidualized-uterus-of-pseudopregnant-rats
#15
K Bridget Brosnihan, Victor M Pulgar, Manish S Bharadwaj, Liomar A A Neves, Liliya M Yamaleyeva
No abstract text is available yet for this article.
March 27, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28322567/access-to-enantiopure-5-7-and-5-7-substituted-cis-decahydroquinolines-enantioselective-synthesis-of-cermizine-b
#16
Alexandre Pinto, Rosa Griera, Elies Molins, Israel Fernández, Joan Bosch, Mercedes Amat
Stereoconvergent cyclocondensation reactions of (R)- or (S)-phenylglycinol with appropriately substituted cyclohexanone-based δ-keto esters are the key steps of short synthetic routes to enantiopure 5-, 7-, and 5,7-substituted cis-decahydroquinolines. The factors governing the stereoselectivity of the cyclocondensation are discussed. The potential of the methodology is illustrated by a protecting-group-free synthesis of the phlegmarine-type Lycopodium alkaloid (-)-cermizine B.
April 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28316823/a-new-solvate-of-afatinib-a-specific-inhibitor-of-the-erbb-family-of-tyrosine-kinases
#17
Matthias Zeller, Gabriel Lima Barros de Araujo, Trev Parker, Amrinder Singh Rai, Stephen R Byrn
Afatinib (systematic name: N-{4-(3-chloro-4-fluoro-anilino)-7-[(tetra-hydro-furan-3-yl)-oxy]quinazolin-6-yl}-4-(di-methyl-amino)-but-2-enamide), is a specific in-hibitor of the ErbB family of tyrosine kinases. The free base form crystallizes from aceto-nitrile as a mixed water-aceto-nitrile solvent, C24H25ClFN5O3·0.25C2H3N·2H2O. It crystallizes with two independent mol-ecules (A and B) in the asymmetric unit of the chiral space group P4212, but exhibits close to perfect pseudo-inversion symmetry, emulating P4/ncc that relates the two mol-ecules to each other...
March 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28286104/akr1b10-inhibitory-selaginella-tamariscina-extract-and-amentoflavone-decrease-the-growth-of-a549-human-lung-cancer-cells-in-vitro-and-in-vivo
#18
Yu-Jin Jung, Eun Ha Lee, Chang Gun Lee, Ki-Jong Rhee, Woo-Suk Jung, Yongsoo Choi, Cheol-Ho Pan, Kyungsu Kang
ETHNOPHARMACOLOGICAL RELEVANCE: Selaginella tamariscina (P.Beauv.) Spring is a traditional medicinal plant used to treat various human diseases, including cancer, in Asia. The detailed molecular mechanism underlying the anti-cancer effects of this plant and the anti-cancer action of the combinatorial treatment of S. tamariscina and doxorubicin have not yet been investigated. AIM OF THE STUDY: We evaluated the inhibitory activity of S. tamariscina extract (STE) and its major compound, amentoflavone, on human aldo-keto reductase family 1B10 (AKR1B10), which is a detoxification enzyme involved in drug resistance, to evaluate their anti-cancer effects and their potential as adjuvant agents for doxorubicin cancer chemotherapy...
March 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28278373/potential-metabolic-activation-of-a-representative-c4-alkylated-polycyclic-aromatic-hydrocarbon-retene-1-methyl-7-isopropyl-phenanthrene-associated-with-the-deepwater-horizon-oil-spill-in-human-hepatoma-hepg2-cells
#19
Meng Huang, Clementina Mesaros, Linda C Hackfeld, Richard P Hodge, Tianzhu Zang, Ian A Blair, Trevor M Penning
Exposure to petrogenic polycyclic aromatic hydrocarbons (PPAHs) in the food chain is the major human health hazard associated with the Deepwater Horizon oil spill. C4-Phenanthrenes are representative PPAHs present in the crude oil and could contaminate the seafood. We describe the metabolism of a C4-phenanthrene regioisomer retene (1-methyl-7-isopropyl-phenanthrene) in human HepG2 cells as a model for metabolism in human hepatocytes. Retene because of its sites of alkylation cannot be metabolized to a diol-epoxide...
April 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28261181/clustered-genes-encoding-2-keto-l-gulonate-reductase-and-l-idonate-5-dehydrogenase-in-the-novel-fungal-d-glucuronic-acid-pathway
#20
Joosu Kuivanen, Mikko Arvas, Peter Richard
D-Glucuronic acid is a biomass component that occurs in plant cell wall polysaccharides and is catabolized by saprotrophic microorganisms including fungi. A pathway for D-glucuronic acid catabolism in fungal microorganisms is only partly known. In the filamentous fungus Aspergillus niger, the enzymes that are known to be part of the pathway are the NADPH requiring D-glucuronic acid reductase forming L-gulonate and the NADH requiring 2-keto-L-gulonate reductase that forms L-idonate. With the aid of RNA sequencing we identified two more enzymes of the pathway...
2017: Frontiers in Microbiology
keyword
keyword
77076
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"