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Nicotine replacement therapy

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https://www.readbyqxmd.com/read/29912798/phase-iib-trial-of-an-%C3%AE-7-nicotinic-receptor-partial-agonist-with-and-without-nicotine-patch-for-withdrawal-associated-cognitive-deficits-and-tobacco-abstinence
#1
Randi Melissa Schuster, Gladys N Pachas, Luke Stoeckel, Corinne Cather, Mireya Nadal, David Mischoulon, David A Schoenfeld, Haiyue Zhang, Christine Ulysse, Elisabeth B Dodds, Sara Sobolewski, Vicenta Hudziak, Ailish Hanly, Maurizio Fava, A Eden Evins
PURPOSE/BACKGROUND: The objective of this study was to determine whether a novel α7 nicotinic acetylcholine receptor partial agonist improves cognition during nicotine withdrawal and improves abstinence rates. To do so, the effect of the α7 nicotinic acetylcholine receptor partial agonist, encenicline, on cognition and abstinence was evaluated when given as monotherapy and when combined with transdermal nicotine patch (nicotine replacement therapy [NRT]). METHODS: Adult daily smokers, n = 160, who were motivated to quit smoking completed cognitive testing at satiated baseline and after overnight abstinence and then were randomized to receive a 12-week trial of encenicline 1 mg twice daily or identical placebo the day of the overnight abstinent cognitive testing...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29908433/a-retrospective-analysis-of-the-association-between-providing-nicotine-replacement-therapy-at-admission-and-motivation-to-quit-and-nicotine-withdrawal-symptoms-during-an-inpatient-psychiatric-hospitalization
#2
Chizimuzo T C Okoli, Yazan D Al-Mrayat, Charles I Shelton, Milan Khara
BACKGROUND: Psychiatric patients have high tobacco use prevalence, dependence, and withdrawal severity. A tobacco-free psychiatric hospitalization necessitates the management of nicotine withdrawal (NW) for tobacco using patients. NW management often requires the provision of approved nicotine replacement therapy (NRT) to patients, which may also motivate tobacco users towards cessation. However, few studies have examined the associations between providing NRT, motivation to quit, and NW among psychiatric patients...
June 7, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29902683/anthropometric-and-body-composition-changes-in-smokers-vs-abstainers-following-an-exercise-aided-pharmacotherapy-smoking-cessation-trial-for-women
#3
Harry Prapavessis, Stefanie De Jesus, Lyndsay Fitzgeorge, Scott Rollo
INTRODUCTION: Post-cessation weight gain contributes to smoking relapse, especially for women. Furthermore, excess weight in the form of android or visceral fat is associated with metabolic health problems. For this study, a secondary analysis was conducted in 2015 to determine whether quitting status, achieved through a 14 week supervised exercise-aided nicotine replacement therapy (NRT) cessation program [Getting Physical on Cigarette Trial-2009 to 2013; Prapavessis, et al., 2016], affects anthropometric and body composition parameters in female smokers (N = 413, M age = 42...
June 7, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29898654/developmental-nicotine-exposure-affects-larval-brain-size-and-the-adult-dopaminergic-system-of-drosophila-melanogaster
#4
Melanie Morris, Ariel Shaw, Madison Lambert, Haley Halperin Perry, Eve Lowenstein, David Valenzuela, Norma Andrea Velazquez-Ulloa
BACKGROUND: Pregnant women may be exposed to nicotine if they smoke or use tobacco products, nicotine replacement therapy, or via e-cigarettes. Prenatal nicotine exposure has been shown to have deleterious effects on the nervous system in mammals including changes in brain size and in the dopaminergic system. The genetic and molecular mechanisms for these changes are not well understood. A Drosophila melanogaster model for these effects of nicotine exposure could contribute to faster identification of genes and molecular pathways underlying these effects...
June 14, 2018: BMC Developmental Biology
https://www.readbyqxmd.com/read/29891957/impact-of-nicotine-replacement-therapy-as-an-adjunct-to-anti-tuberculosis-treatment-and-behaviour-change-counselling-in-newly-diagnosed-pulmonary-tuberculosis-patients-an-open-label-randomised-controlled-trial
#5
Surendra Kumar Sharma, Alladi Mohan, Achintya Dinesh Singh, Hridesh Mishra, Sonali Jhanjee, Ravindra Mohan Pandey, Binit Kumar Singh, Rohini Sharma, Prakash Babu Pallipamu, Madhukar Pai, Keertan Dheda
We evaluated the impact of intensive smoking cessation activities as an adjunct to anti-tuberculosis treatment on patient-related treatment outcomes. In this open-label, randomised controlled trial, self-reporting smokers with pulmonary tuberculosis who initiated standard anti-tuberculosis treatment were randomised to either nicotine replacement therapy and behaviour change counselling (n = 400) or counselling alone (n = 400) provided at baseline and two follow-up visits. The primary outcomes were change in TBscore at 24-weeks and culture conversion at 8-weeks...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29889172/engaging-smokeless-tobacco-users-in-population-based-cessation-services-findings-from-an-observational-study
#6
Paula A Keller, Raymond G Boyle, Rebecca K Lien, Bruce Christiansen, Kate Kobinsky
Although telephone quitlines are effective for helping smokeless tobacco (ST) users quit, ST users are underrepresented among quitline participants. After ClearWay Minnesota implemented multiple changes to its quitline service (QUITPLAN® Services), utilization increased dramatically, including by ST users. We examined data from Minnesota and Wisconsin to determine whether these changes were unique to Minnesota. Four years of quitline registration data were analyzed for both states. A significant increase in enrollees reporting any ST use was seen in Minnesota after changes were made to services; no change was seen in Wisconsin...
June 7, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29886411/cost-effectiveness-analysis-of-smoking-cessation-interventions-using-cell-phones-in-a-low-income-population
#7
Allan T Daly, Ashish A Deshmukh, Damon J Vidrine, Alexander V Prokhorov, Summer G Frank, Patricia D Tahay, Maggie E Houchen, Scott B Cantor
BACKGROUND: The prevalence of cigarette smoking is significantly higher among those living at or below the federal poverty level. Cell phone-based interventions among such populations have the potential to reduce smoking rates and be cost-effective. METHODS: We performed a cost-effectiveness analysis of three smoking cessation interventions: Standard Care (SC) (brief advice to quit, nicotine replacement therapy and self-help written materials), Enhanced Care (EC) (SC plus cell phone-delivered messaging) and Intensive Care (IC) (EC plus cell phone-delivered counselling)...
June 9, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29881956/the-safety-and-efficacy-of-nicotine-replacement-therapy-in-the-intensive-care-unit-a-randomised-controlled-pilot-study
#8
Ben de Jong, Anne Sophie Schuppers, Arriette Kruisdijk-Gerritsen, Maurits Erwin Leo Arbouw, Hubertus Laurentius Antonius van den Oever, Arthur R H van Zanten
BACKGROUND: Studies evaluating nicotine replacement therapy (NRT) to prevent nicotine withdrawal symptoms in ICU patients have yielded conflicting results. We performed a randomised controlled double-blind pilot study to assess the safety and efficacy of NRT in critically ill patients. Mechanically ventilated patients admitted to two medical-surgical intensive care units and smoking more than 10 cigarettes per day before ICU admission were enrolled in this study. Participants were randomised to transdermal NRT (14 or 21 mg per day) or placebo until ICU discharge or day 30...
June 7, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29878062/improving-adherence-to-smoking-cessation-treatment-smoking-outcomes-in-a-web-based-randomized-trial
#9
Amanda L Graham, George D Papandonatos, Sarah Cha, Bahar Erar, Michael S Amato
Background: Partial adherence in Internet smoking cessation interventions presents treatment and evaluation challenges. Increasing adherence may improve outcomes. Purpose: To present smoking outcomes from an Internet randomized trial of two strategies to encourage adherence to tobacco dependence treatment components: (i) a social network (SN) strategy to integrate smokers into an online community and (ii) free nicotine replacement therapy (NRT). In addition to intent-to-treat analyses, we used novel statistical methods to distinguish the impact of treatment assignment from treatment utilization...
March 15, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29864548/the-healing-and-empowering-alaskan-lives-toward-healthy-hearts-healthh-project-study-protocol-for-a-randomized-controlled-trial-of-an-intervention-for-tobacco-use-and-other-cardiovascular-risk-behaviors-for-alaska-native-people
#10
Judith J Prochaska, Anna Epperson, Jordan Skan, Marily Oppezzo, Paul Barnett, Kevin Delucchi, Matthew Schnellbaecher, Neal L Benowitz
BACKGROUND: Tobacco use and tobacco-related diseases disproportionately affect Alaska Native (AN) people. Using telemedicine, this study aims to identify culturally-tailored, theoretically-driven, efficacious interventions for tobacco use and other cardiovascular disease (CVD) risk behaviors among AN people in remote areas. DESIGN: Randomized clinical trial with two intervention arms: 1) tobacco and physical activity; 2) medication adherence and a heart-healthy AN diet...
June 1, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29852054/nicotine-replacement-therapy-versus-control-for-smoking-cessation
#11
REVIEW
Jamie Hartmann-Boyce, Samantha C Chepkin, Weiyu Ye, Chris Bullen, Tim Lancaster
BACKGROUND: Nicotine replacement therapy (NRT) aims to temporarily replace much of the nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms, thus easing the transition from cigarette smoking to complete abstinence. OBJECTIVES: To determine the effectiveness and safety of nicotine replacement therapy (NRT), including gum, transdermal patch, intranasal spray and inhaled and oral preparations, for achieving long-term smoking cessation, compared to placebo or 'no NRT' interventions...
May 31, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29844912/adverse-events-of-smoking-cessation-treatments-nicotine-replacement-therapy-and-non-nicotine-prescription-medication-and-electronic-cigarettes-in-the-food-and-drug-administration-adverse-event-reporting-system-2004-2016
#12
Yumi Motooka, Toshinobu Matsui, Rachel M Slaton, Ryogo Umetsu, Akiho Fukuda, Misa Naganuma, Shiori Hasegawa, Sayaka Sasaoka, Haruna Hatahira, Kazuhiro Iguchi, Mitsuhiro Nakamura
Objectives: Several smoking cessation treatments (nicotine replacement therapy and non-nicotine prescription medication) and electronic cigarettes are widely used. We evaluated the adverse events related to smoking cessation treatments and electronic cigarettes in the US Food and Drug Administration Adverse Event Reporting System database. Methods: We analyzed reports of adverse events associated with smoking cessation treatment and electronic cigarettes terms dated between January 2004 and December 2016...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29791259/a-pragmatic-trial-of-e-cigarettes-incentives-and-drugs-for-smoking-cessation
#13
Scott D Halpern, Michael O Harhay, Kathryn Saulsgiver, Christine Brophy, Andrea B Troxel, Kevin G Volpp
Background Whether financial incentives, pharmacologic therapies, and electronic cigarettes (e-cigarettes) promote smoking cessation among unselected smokers is unknown. Methods We randomly assigned smokers employed by 54 companies to one of four smoking-cessation interventions or to usual care. Usual care consisted of access to information regarding the benefits of smoking cessation and to a motivational text-messaging service. The four interventions consisted of usual care plus one of the following: free cessation aids (nicotine-replacement therapy or pharmacotherapy, with e-cigarettes if standard therapies failed); free e-cigarettes, without a requirement that standard therapies had been tried; free cessation aids plus $600 in rewards for sustained abstinence; or free cessation aids plus $600 in redeemable funds, deposited in a separate account for each participant, with money removed from the account if cessation milestones were not met...
May 23, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29788791/nicotine-metabolite-ratio-and-smoking-outcomes-using-nicotine-replacement-therapy-and-varenicline-among-smokers-with-and-without-psychiatric-illness
#14
Matthew Clyde, Andrew Pipe, Charl Els, Robert Reid, Angel Fu, Alexa Clark, Heather Tulloch
INTRODUCTION: It has been suggested that the effectiveness of nicotine replacement smoking cessation pharmacotherapy may be enhanced by assessing rates of nicotine metabolism using the nicotine metabolite ratio - which reflects differences in the activity of the CYP2A6 hepatic enzyme - and titrating doses appropriately. To date, supporting evidence is equivocal, with little information regarding the assessment and effectiveness of the nicotine metabolite ratio among smokers with psychiatric conditions...
May 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29787858/a-randomized-clinical-trial-of-counseling-and-nicotine-replacement-therapy-for-treatment-of-african-american-non-daily-smokers-design-accrual-and-baseline-characteristics
#15
Nicole L Nollen, Lisa Sanderson Cox, Matthew S Mayo, Edward F Ellerbeck, Sheshadri Madhusudhana, Jasjit S Ahluwalia
BACKGROUND: Non-daily smokers (NDS) who smoke on some but not all days are a growing subset of United States (US) tobacco users. Racial/ethnic minorities are more likely to be NDS. African American NDS have strikingly high levels of nicotine and carcinogen exposure, making treatment of this high risk group a priority. METHODS: The current study is one of three ongoing federally-funded clinical trials of NDS and, to our knowledge the only RCT focused on racial/ethnic minority NDS...
May 19, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29776349/randomised-controlled-trial-rct-of-cannabinoid-replacement-therapy-nabiximols-for-the-management-of-treatment-resistant-cannabis-dependent-patients-a-study-protocol
#16
Anjali K Bhardwaj, David J Allsop, Jan Copeland, Iain S McGregor, Adrian Dunlop, Marian Shanahan, Raimondo Bruno, Nghi Phung, Mark Montebello, Craig Sadler, Jessica Gugusheff, Melissa Jackson, Jennifer Luksza, Nicholas Lintzeris
BACKGROUND: The cannabis extract nabiximols (Sativex®) effectively supresses withdrawal symptoms and cravings in treatment resistant cannabis dependent individuals, who have high relapse rates following conventional withdrawal treatments. This study examines the efficacy, safety and cost-effectiveness of longer-term nabiximols treatment for outpatient cannabis dependent patients who have not responded to previous conventional treatment approaches. METHODS/DESIGN: A phase III multi-site outpatient, randomised, double-blinded, placebo controlled parallel design, comparing a 12-week course of nabiximols to placebo, with follow up at 24 weeks after enrolment...
May 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29773262/-smoking-cessation-pharmacological-strategies-different-from-standard-treatments
#17
REVIEW
M Underner, J Perriot, G Peiffer, G Harika-Germaneau, N Jaafari
INTRODUCTION: Three drugs are used as an aid for smoking cessation: nicotine replacement therapy (NRT), varenicline and bupropion. Standard pharmacological strategies have proven their efficacy but may have poor efficacy, especially among "Hard-core smokers" who display low smoking abstinence rates and high relapse rates. OBJECTIVES: Systematic literature review of data on pharmacological strategies for smoking cessation which are different from standard treatments...
May 14, 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29766615/barriers-and-facilitators-to-smoking-cessation-in-pregnancy-and-in-the-post-partum-period-the-health-care-professionals-perspective
#18
Felix Naughton, Sarah Hopewell, Lesley Sinclair, Dorothy McCaughan, Jennifer McKell, Linda Bauld
OBJECTIVES: Health care professionals and the health care environment play a central role in protecting pregnant and post-partum women and their infants from smoking-related harms. This study aimed to better understand the health professional's perspective on how interactions between women, health care professionals, and the environment influence how smoking is managed. DESIGN: Semi-structured interviews and focus groups. METHODS: Data were from 48 health care staff involved in antenatal or post-partum care at two UK sites, including midwives, obstetricians, health visitors, GPs, pharmacists, service commissioners, and Stop Smoking Service (SSS) advisors and managers...
May 15, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29747516/impact-and-effectiveness-of-a-stand-alone-nrt-starter-kit-in-a-statewide-tobacco-cessation-program
#19
Amy N Kerr, Barbara A Schillo, Paula A Keller, Randi B Lachter, Rebecca K Lien, Heather G Zook
PURPOSE: To examine 2-week nicotine replacement therapy (NRT) starter kit quit outcomes and predictors and the impact of adding this new service on treatment reach. DESIGN: Observational study of a 1-year cohort of QUITPLAN Services enrollees using registration and utilization data and follow-up outcome survey data of a subset of enrollees who received NRT starter kits. SETTING: ClearWay Minnesota's QUITPLAN Services provides a quit line that is available to uninsured and underinsured Minnesotans and NRT starter kits (a free 2-week supply of patches, gum, or lozenges) that are available to all Minnesota tobacco users...
January 1, 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29746451/tobacco-cessation-interventions-and-smoke-free-policies-in-mental-health-and-substance-abuse-treatment-facilities-united-states-2016
#20
Kristy Marynak, Brenna VanFrank, Sonia Tetlow, Margaret Mahoney, Elyse Phillips, Ahmed Jamal Mbbs, Anna Schecter, Doug Tipperman, Stephen Babb
Persons with mental or substance use disorders or both are more than twice as likely to smoke cigarettes as persons without such disorders and are more likely to die from smoking-related illness than from their behavioral health conditions (1,2). However, many persons with behavioral health conditions want to and are able to quit smoking, although they might require more intensive treatment (2,3). Smoking cessation reduces smoking-related disease risk and could improve mental health and drug and alcohol recovery outcomes (1,3,4)...
May 11, 2018: MMWR. Morbidity and Mortality Weekly Report
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