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Nicotine replacement therapy

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https://www.readbyqxmd.com/read/29220743/the-cigarette-dependence-scale-and-heaviness-of-smoking-index-as-predictors-of-smoking-cessation-after-10weeks-of-nicotine-replacement-therapy-and-at-6-month-follow-up
#1
Laurie Zawertailo, Sabrina Voci, Peter Selby
INTRODUCTION: The reliability and validity of the Cigarette Dependence Scale (CDS) has been tested in online studies and compared with other tobacco dependence measures. Findings regarding its ability to predict smoking cessation have been mixed. We examined whether the CDS predicted cessation among a sample that received nicotine replacement therapy (NRT) at a community workshop and assessed the incremental predictive validity of the CDS-5 and CDS-12 over the 2-item Heaviness of Smoking Index (HSI)...
November 27, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29205283/clinician-factors-associated-with-prescribing-nicotine-replacement-therapy-in-pregnancy-a-cross-sectional-survey-of-australian-obstetricians-and-general-practitioners
#2
Yael Bar-Zeev, Billie Bonevski, Maree Gruppetta, Laura Twyman, Lou Atkins, Kerrin Palazzi, Christopher Oldmeadow, Gillian S Gould
The use of nicotine replacement therapy in pregnancy has been debated but evidence suggests that it is safer than smoking. A cross-sectional survey was conducted with: (i) general practitioners and obstetricians from a college database; and (ii) general practitioners with a special interest in Indigenous health. General practitioners had higher odds of prescribing compared to obstetricians. Reading guidelines, confidence, viewing nicotine replacement therapy as safe, effective and with good adherence, also significantly increased the odds of prescription...
December 4, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29196725/pharmacogenetic-study-of-seven-polymorphisms-in-three-nicotinic-acetylcholine-receptor-subunits-in-smoking-cessation-therapies
#3
Giulia Pintarelli, Antonella Galvan, Paolo Pozzi, Sara Noci, Giovanna Pasetti, Francesca Sala, Ugo Pastorino, Roberto Boffi, Francesca Colombo
Smoking-cessation therapy reduces the risk of smoking-related diseases, but is successful only in a fraction of smokers. There is growing evidence that genetic variations in nicotinic acetylcholine receptor (nAChR) subunits influence the risk of nicotine dependence and the ability to quit smoking. To investigate the role of polymorphisms in nAChR genes on smoking quantity and the outcome of smoking-cessation therapies, we carried out an association study on 337 smokers who underwent pharmacotherapy with varenicline, bupropion, nicotine replacement therapy (NRT) alone, or NRT plus bupropion...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29193747/single-dose-bioequivalence-of-two-mini-nicotine-lozenge-formulations
#4
Scott C Rasmussen, William D Becker, Gilbert M Shanga
Diverse nicotine replacement therapy options may improve consumer usage. This study was conducted to establish the bioequivalence of a new cherry-flavored mini lozenge with that of a currently marketed mint-flavored mini lozenge. The rate (Cmax ) and extent (AUC0-t ) of plasma nicotine absorption were compared after administration of 2- and 4-mg doses of each lozenge in healthy adult smokers (n = 43). The bioequivalence of each respective dose was established based on the 90% confidence interval for the ratio of geometric means for both Cmax and AUC0-t lying within the range of 0...
November 28, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29183347/the-effect-of-an-intensive-smoking-cessation-intervention-on-disease-activity-in-patients-with-rheumatoid-arthritis-study-protocol-for-a-randomised-controlled-trial
#5
Ida Kristiane Roelsgaard, Thordis Thomsen, Mikkel Østergaard, Robin Christensen, Merete Lund Hetland, Søren Jacobsen, Lena Andersen, Hanne Tønnesen, Silvia Rollefstad, Anne Grete Semb, Bente Appel Esbensen
BACKGROUND: Rheumatoid arthritis (RA) is a chronic, inflammatory rheumatic disease with the potential to induce significant disability. Patients with RA are at increased risk of cardiovascular diseases (CVD). Smokers with RA tend to experience more pain and fatigue, higher disease activity, more erosive joint destruction and a lower health-related quality of life (HR-QoL) than non-smokers. It remains to be determined whether these effects can be reduced by smoking cessation. This randomised controlled trial (RCT) in patients with RA aims to examine the effect of intensive smoking cessation intervention (motivational counselling combined with tailored nicotine replacement therapy) versus standard care on smoking cessation, and consequently on disease activity...
November 28, 2017: Trials
https://www.readbyqxmd.com/read/29180549/family-physicians-perceived-prevalence-safety-and-screening-for-cigarettes-marijuana-and-electronic-nicotine-delivery-systems-ends-use-during-pregnancy
#6
Thomas F Northrup, Michelle R Klawans, Yolanda R Villarreal, Adi Abramovici, Melissa A Suter, Joan M Mastrobattista, Carlos A Moreno, Kjersti M Aagaard, Angela L Stotts
OBJECTIVE: Assess perceptions of prevalence, safety, and screening practices for cigarettes and secondhand smoke exposure (SHSe), marijuana (and synthetic marijuana), electronic nicotine delivery systems (ENDS; eg, e-cigarettes), nicotine-replacement therapy (NRT), and smoking-cessation medications during pregnancy, among primary care physicians (PCPs) providing obstetric care. METHODS: A web-based, cross-sectional survey was e-mailed to 3750 US physicians (belonging to organizations within the Council of Academic Family Medicine Educational Research Alliance)...
November 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29175360/efficacy-of-acupuncture-is-non-inferior-to-nrt-for-tobacco-cessation-results-of-a-prospective-randomized-active-controlled-open-label-trial
#7
Ying-Ying Wang, Zhao Liu, Yuan Wu, Li Yang, Lang-Tao Guo, Hao-Bin Zhang, Jin-Sheng Yang
OBJECTIVE: We designed and conducted this multicenter randomized active-controlled open-label trial to evaluate the efficacy of acupuncture, auricular point pressing and nicotine replacement therapy (NRT) on tobacco cessation in Chinese population. METHODS: This RCT was conducted at 7 hospitals in China between October of 2013 to February of 2016. Eligible participants were recruited and randomly assigned to receive acupuncture or auricular point pressing or NRT via a central randomization system with a 1:1:1 ratio...
November 23, 2017: Chest
https://www.readbyqxmd.com/read/29173283/using-lean-quality-improvement-tools-to-increase-delivery-of-evidence-based-tobacco-use-treatment-in-hospitalized-neurosurgical-patients
#8
Laurel Sisler, Oluwaseun Omofoye, Karina Paci, Eldad Hadar, Adam O Goldstein, Carol Ripley-Moffitt
BACKGROUND: Health care providers routinely undertreat tobacco dependence, indicating a need for innovative ways to increase delivery of evidence-based care. Lean, a set of quality improvement (QI) tools used increasingly in health care, can help streamline processes, create buy-in for use of evidence-based practices, and lead to the identification of solutions on the basis of a problem's root causes. To date, no published research has examined the use of Lean tools in tobacco dependence...
December 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/29163051/young-human-cholinergic-neurons-respond-to-physiological-regulators-and-improve-cognitive-symptoms-in-an-animal-model-of-alzheimer-s-disease
#9
Annamaria Morelli, Erica Sarchielli, Giulia Guarnieri, Elisabetta Coppi, Daniela Pantano, Paolo Comeglio, Pamela Nardiello, Anna M Pugliese, Lara Ballerini, Rosanna Matucci, Stefano Ambrosini, Giuseppe Castronovo, Rosa Valente, Benedetta Mazzanti, Sandra Bucciantini, Mario Maggi, Fiorella Casamenti, Pasquale Gallina, Gabriella B Vannelli
The degeneration of cholinergic neurons of the nucleus basalis of Meynert (NBM) in the basal forebrain (BF) is associated to the cognitive decline of Alzheimer's disease (AD) patients. To date no resolutive therapies exist. Cell-based replacement therapy is a strategy currently under consideration, although the mechanisms underlying the generation of stem cell-derived NBM cholinergic neurons able of functional integration remain to be clarified. Since fetal brain is an optimal source of neuronal cells committed towards a specific phenotype, this study is aimed at isolating cholinergic neurons from the human fetal NBM (hfNBMs) in order to study their phenotypic, maturational and functional properties...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29158210/longitudinal-influence-of-pregnancy-on-nicotine-metabolic-pathways
#10
Taraneh Taghavi, Christopher A Arger, Sarah H Heil, Stephen T Higgins, Rachel F Tyndale
Nicotine metabolism increases in pregnancy which may contribute to the difficulties that pregnant women have in quitting smoking. We aimed to determine the extent and timing of changes in nicotine metabolic pathways, including C-oxidation, N-glucuronidation, and the pregnancy-induced influences on the activity of enzymes mediating these pathways (CYP2A6 and UGT2B10, respectively). Current smoking pregnant women (n=47) provided a urine sample during early pregnancy (12.5 weeks), late pregnancy (28.9 weeks), and 6 months postpartum...
November 20, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29150536/availability-sales-and-affordability-of-tobacco-cessation-medicines-in-kerala-india
#11
Smitha Sarma, Sivadasanpillai Harikrishnan, Abigail S Baldridge, Raji Devarajan, Aashna Mehta, Sakhtivel Selvaraj, Mohammed K Ali, Padinhare P Mohanan, Dorairaj Prabhakaran, Mark D Huffman
BACKGROUND: India is the world's second largest consumer of tobacco, but tobacco cessation remains uncommon due, at least in part, to underutilization of cessation pharmacotherapy. We evaluated the availability, sales, and affordability of nicotine replacement therapy, bupropion, and varenicline in the South Indian state of Kerala to understand potential reasons for underutilization. METHODS AND RESULTS: From November 2016 to April 2017, we collected data on availability, inventory, and pricing of cessation medication through a cross-sectional survey of 199 public, semiprivate (Karunya), and private pharmacies across 5 districts in Kerala using World Health Organization/Health Action International methodology...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29149048/quit-methods-used-by-american-smokers-2013-2014
#12
Brad Rodu, Nantaporn Plurphanswat
This report describes the quit methods used in the past 12 months by current and former smokers in the baseline Population Assessment of Tobacco and Health (PATH) Study during 2013-2014. Descriptive statistics were used to report the use of single and two or more quit methods; survey weights were used to compute population estimates. Logistic regression was used to estimate the association between past year former smokers and single quit method, including individual characteristics. RESULTS: Of 11,402 current smokers and 4919 former smokers, 4541 had tried and 839 had quit in the past 12 months...
November 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29148565/tobacco-cessation-interventions-for-young-people
#13
REVIEW
Thomas R Fanshawe, William Halliwell, Nicola Lindson, Paul Aveyard, Jonathan Livingstone-Banks, Jamie Hartmann-Boyce
BACKGROUND: Most tobacco control programmes for adolescents are based around prevention of uptake, but teenage smoking is still common. It is unclear if interventions that are effective for adults can also help adolescents to quit. This is the update of a Cochrane Review first published in 2006. OBJECTIVES: To evaluate the effectiveness of strategies that help young people to stop smoking tobacco. SEARCH METHODS: We searched the Cochrane Tobacco Addiction Group's Specialized Register in June 2017...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29146649/what-are-older-smokers-attitudes-to-quitting-and-how-are-they-managed-in-primary-care-an-analysis-of-the-cross-sectional-english-smoking-toolkit-study
#14
Hannah Jordan, Mira Hidajat, Nick Payne, Jean Adams, Martin White, Yoav Ben-Shlomo
OBJECTIVES: To investigate whether age is associated with access to smoking cessation services. DESIGN: Data from the Smoking Toolkit Study 2006-2015, a repeated multiwave cross-sectional household survey (n=181 157). SETTING: England. PARTICIPANTS: Past-year smokers who participated in any of the 102 waves stratified into age groups. OUTCOME MEASURES: Amount smoked and nicotine dependency, self-reported quit attempts and use of smoking cessation interventions...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29138902/-use-of-e%C3%A2-cigarettes-as-an-additional-tool-in-a%C3%A2-smoking-cessation-group-intervention-results-after-12%C3%A2-months
#15
Christoph B Kröger, Sarah Ofner, Daniela Piontek
BACKGROUND: E-cigarettes are considerably safer regarding health issues than conventional cigarettes, but there is uncertainty concerning its use for smoking cessation. OBJECTIVES: How and to what extent are E‑cigarettes used by smokers willing to quit? Are E‑cigarettes a useful intervention for smokers attending a group intervention for smoking cessation? MATERIALS AND METHODS: One year after attending a group intervention for smoking cessation in Germany, 637 attendants were assessed by telephone...
November 14, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29131057/unaided-smoking-cessation-in-healthy-employees
#16
Meryem Manis, Michael Tamm, Daiana Stolz
BACKGROUND: According to guidelines, behavioral and pharmacological assistance should be offered to all smokers willing to quit. However, a large proportion of ex-cigarette smokers are self-quitters. OBJECTIVES: To identify characteristics of long-term, unaided self-quitters, as compared to recurrent smokers among health care employees. METHODS: University hospital employees (n = 5,218) were addressed through a 17-question questionnaire inquiring about past and current smoking behavior...
November 7, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29130427/reduction-of-anxiety-sensitivity-in-relation-to-nicotine-withdrawal-symptoms-during-smoking-cessation-an-examination-among-successful-quitters
#17
Jafar Bakhshaie, Michael J Zvolensky, Kirsten J Langdon, Adam M Leventhal, Norman B Schmidt
Anxiety sensitivity has been implicated as a potential risk factor for post-quit withdrawal symptoms. The present study examined relations between the extent of change in anxiety sensitivity and the course of nicotine withdrawal symptoms experienced during the initial two weeks of a quit attempt among treatment-seeking smokers. The sample consisted of 29 adult daily smokers (34% female; Mage = 47.7, SD = 13.1) who successfully quit and maintained their abstinence. After adjusting for the effects of gender, treatment condition, use of nicotine replacement therapy, nicotine dependence, alcohol use problems, baseline levels of anxiety sensitivity, and reductions in negative affect, greater reductions in anxiety sensitivity were related to faster decreases in withdrawal symptoms...
November 13, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/29080852/assessment-of-tobacco-heating-product-thp1-0-part-9-the-placement-of-a-range-of-next-generation-products-on-an-emissions-continuum-relative-to-cigarettes-via-pre-clinical-assessment-studies
#18
James Murphy, Chuan Liu, Kevin McAdam, Marianna Gaca, Krishna Prasad, Oscar Camacho, John McAughey, Christopher Proctor
This series of nine papers described the operation and pre-clinical assessment of a tobacco heating product THP1.0. This last paper contextualises the pre-clinical assessment data on THP1.0 with data from other next generation products relative to cigarette smoke. The tobacco and nicotine risk continuum is a concept that ranks products according to their potential harm, with cigarettes at the highest risk extreme and Nicotine Replacement Therapy at the least risky extreme. Data generated in pre-clinical studies on THP1...
October 5, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29076779/cigarette-smoking-and-outcomes-after-aneurysmal-subarachnoid-hemorrhage-a-nationwide-analysis
#19
Hormuzdiyar H Dasenbrock, Robert F Rudy, Pui Man Rosalind Lai, Timothy R Smith, Kai U Frerichs, William B Gormley, M Ali Aziz-Sultan, Rose Du
OBJECTIVE Although cigarette smoking is one of the strongest risk factors for cerebral aneurysm development and rupture, there are limited data evaluating the impact of smoking on outcomes after aneurysmal subarachnoid hemorrhage (SAH). Additionally, two recent studies suggested that nicotine replacement therapy was associated with improved neurological outcomes among smokers who had sustained an SAH compared with smokers who did not receive nicotine. METHODS Patients who underwent endovascular or microsurgical repair of a ruptured cerebral aneurysm were extracted from the Nationwide Inpatient Sample (NIS, 2009-2011) and stratified by cigarette smoking...
October 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29065204/the-role-of-nicotine-dependence-in-e-cigarettes-potential-for-smoking-reduction
#20
Arielle S Selya, Lisa Dierker, Jennifer S Rose, Donald Hedeker, Robin J Mermelstein
Introduction: E-cigarettes (Electronic Nicotine Delivery Systems, or ENDS) are an increasingly popular tobacco product among youth. Some evidence suggests that e-cigarettes may be effective for harm reduction and smoking cessation, although these claims remain controversial. Little is known about how nicotine dependence may contribute to e-cigarettes' effectiveness in reducing or quitting conventional smoking. Methods: A cohort of young adults were surveyed over 4 years (approximately ages 19-23)...
July 7, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
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