Lei Tian, Xiuming Jin, Jibing Wang, Yonggen Xu, Chengwei Lu, Shaozhen Zhao, Qian Zhu, Hong Dai, Hao Gu, Mingchang Zhang, Linnong Wang, Xiaohe Lu, Lixiao Ma, Lei Zhu, Qingyan Zeng, Hong Zhang, Yao Fu, Suxia Li, Liming Tao, Qian Ren, Faming Ding, Shenglin Zhang, Shaopin Zhu, Zhiping Li, Ying Jie
BACKGROUND: Dry eye disease has a high prevalence and exerts a significant negative effect on quality of life. In China, there are currently no available nasal sprays to promote natural tear production in patients with dry eye disease. We therefore evaluated the efficacy and safety of OC-01 (varenicline solution) nasal spray versus vehicle in Chinese patients with dry eye disease. METHODS: This was a randomized, multicenter, double-masked, vehicle-controlled, phase 3 clinical trial conducted at ophthalmology departments in 20 hospitals across China (NCT05378945)...
April 2024: The Lancet Regional Health. Western Pacific