keyword
https://read.qxmd.com/read/38520121/incremental-net-monetary-benefit-of-using-varenicline-for-smoking-cessation-a-systematic-review-and-meta-analysis-of-economic-evaluation-studies
#1
REVIEW
Chayutthaphong Chaisai, Chanthawat Patikorn, Kednapa Thavorn, Shaun Wen Huey Lee, Nathorn Chaiyakunapruk, Sajesh K Veettil
AIMS: To conduct a systematic review and meta-analysis and pool the incremental net benefits (INBs) of varenicline compared with behaviour support with bupropion or nicotine replacement therapy (NRT), behaviour support alone and unaided cessation in adult smokers making a first-time attempt to quit. METHODS: A search for economic evaluation studies was conducted from inception to 30 September 2022, on PubMed, Embase, Cost-Effectiveness Analysis (CEA) Registry by Tufts Medical Centre, EconLit and the NHS Economic Evaluation Database (NHS EED)...
March 22, 2024: Addiction
https://read.qxmd.com/read/38519818/stimulus-mediation-specificity-and-impact-of-menthol-in-rats-trained-to-discriminate-puffs-of-nicotine-e-cigarette-aerosol-from-nicotine-free-aerosol
#2
JOURNAL ARTICLE
Yasmin Alkhlaif, Keith L Shelton
RATIONALE: It is unclear if e-cigarettes have reduced abuse liability relative to traditional cigarettes, especially when considering advanced devices which deliver nicotine more efficiently. Translatable and predictive animal models are needed to addresses this question. OBJECTIVES: Our goal was to explore the subjective stimulus effects of e-cigarettes by training rats to discriminate puffs of nicotine aerosol from vehicle aerosol using an aerosol delivery system designed to model e-cigarette use patterns in humans...
March 23, 2024: Psychopharmacology
https://read.qxmd.com/read/38494828/efficacy-of-varenicline-or-bupropion-and-its-association-with-nicotine-metabolite-ratio-among-smokers-with-copd
#3
JOURNAL ARTICLE
Rui Qin, Zhao Liu, An-Qi Cheng, Xin-Mei Zhou, Zheng Su, Zi-Yang Cui, Jin-Xuan Li, Xiao-Wen Wei, Liang Zhao, Kian Fan Chung, Dan Xiao, Chen Wang
BACKGROUND AND OBJECTIVE: Nicotine metabolic ratio (NMR) has been associated with nicotine metabolism and smoking characteristics. However, there are few studies on the potential association between NMR and smoking cessation efficacy in smokers with chronic obstructive pulmonary disease (COPD) in China or elsewhere. METHODS: This study was a stratified block randomized controlled trial for smoking cessation in Chinese smokers with COPD. NMR was used as a stratification factor; slow metabolizers were defined as those with NMR <0...
March 17, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/38481929/effectiveness-of-healthcare-interventions-on-smoking-cessation-in-adolescents-in-low-and-middle-income-countries-a-narrative-review
#4
REVIEW
Janhvi Thakur, Sonali G Choudhari
The smoking epidemic is the greatest threat to global public health that has ever existed. Teenagers constantly perceive smoking as a way to communicate with friends and express their emotions. Adolescent smokers should be noticed immediately before the extended period of tobacco addiction and being resistant to the interventions. The aim of this study is to assess the effectiveness of healthcare interventions targeting smoking cessation in adolescents within low- and middle-income countries (LMICs) and to summarize the options, benefits, and affordability of interventions for quitting smoking that may be implemented in LMICs...
February 2024: Curēus
https://read.qxmd.com/read/38440130/varenicline-solution-nasal-spray-for-dry-eye-disease-in-chinese-patients-a-randomized-phase-3-trial
#5
JOURNAL ARTICLE
Lei Tian, Xiuming Jin, Jibing Wang, Yonggen Xu, Chengwei Lu, Shaozhen Zhao, Qian Zhu, Hong Dai, Hao Gu, Mingchang Zhang, Linnong Wang, Xiaohe Lu, Lixiao Ma, Lei Zhu, Qingyan Zeng, Hong Zhang, Yao Fu, Suxia Li, Liming Tao, Qian Ren, Faming Ding, Shenglin Zhang, Shaopin Zhu, Zhiping Li, Ying Jie
BACKGROUND: Dry eye disease has a high prevalence and exerts a significant negative effect on quality of life. In China, there are currently no available nasal sprays to promote natural tear production in patients with dry eye disease. We therefore evaluated the efficacy and safety of OC-01 (varenicline solution) nasal spray versus vehicle in Chinese patients with dry eye disease. METHODS: This was a randomized, multicenter, double-masked, vehicle-controlled, phase 3 clinical trial conducted at ophthalmology departments in 20 hospitals across China (NCT05378945)...
April 2024: The Lancet Regional Health. Western Pacific
https://read.qxmd.com/read/38438884/identifying-determinants-of-varenicline-adherence-using%C3%A2-the-theoretical-domains-framework-a-rapid-review
#6
REVIEW
Nadia Minian, Melissa Wong, Sowsan Hafuth, Terri Rodak, Alma Rahimi, Dea Gjomema, Jonathan Rose, Laurie Zawertailo, Matt Ratto, Peter Selby
BACKGROUND: Adhering to varenicline has been shown to significantly improve the chances of successfully quitting smoking, with studies indicating a twofold increase in 6-month quit rates. However, despite its potential benefits, many individuals struggle with maintaining good adherence to varenicline; thus there is a need to develop scalable strategies to help people adhere. As a first step to inform the development of an intervention to improve adherence to varenicline, we conducted a rapid literature review to identify: 1) modifiable barriers and facilitators to varenicline adherence, and 2) behaviour change techniques associated with increased adherence to varenicline...
March 4, 2024: BMC Public Health
https://read.qxmd.com/read/38430396/changes-in-distinct-brain-systems-identified-with-fmri-during-smoking-cessation-treatment-with-varenicline-a-review
#7
REVIEW
Vassilis N Panagopoulos, Alexis Bailey, George K Kostopoulos, Andreas A Ioannides
BACKGROUND: Varenicline is considered one of the most effective treatment options for smoking cessation. Nonetheless, it is only modestly effective. A deeper comprehension of the effects of varenicline by means of the in-depth review of relevant fMRI studies may assist in paving the development of more targeted and effective treatments. METHODOLOGY: A search of PubMed and Google Scholar databases was conducted with the keywords "functional magnetic resonance imaging" or "fMRI", and "varenicline"...
March 2, 2024: Psychopharmacology
https://read.qxmd.com/read/38414371/evidence-based-guideline-for-the-treatment-of-smoking-cessation-provided-by-the-national-health-insurance-service-in-korea
#8
JOURNAL ARTICLE
Cheol Min Lee, Yoo-Bin Seo, Yu-Jin Paek, Eon Sook Lee, Hye Seon Kang, Soo Young Kim, Sungwon Roh, Dong Won Park, Yoo Suk An, Sang-Ho Jo
Although major countries, such as South Korea, have developed and disseminated national smoking cessation guidelines, these efforts have been limited to developing individual societies or specialized institution-based recommendations. Therefore, evidence-based clinical guidelines are essential for developing smoking cessation interventions and promoting effective smoking cessation treatments. This guideline targets frontline clinical practitioners involved in a smoking cessation treatment support program implemented in 2015 with the support of the National Health Insurance Service...
February 28, 2024: Korean Journal of Family Medicine
https://read.qxmd.com/read/38408207/correction-to-cytisine-versus-varenicline-for-smoking-cessation-in-a-primary-care-setting-a-randomized-non-inferiority-trial
#9
(no author information available yet)
No abstract text is available yet for this article.
February 26, 2024: Nicotine & Tobacco Research
https://read.qxmd.com/read/38392926/managing-dry-eye-disease-with-novel-medications-mechanism-study-validity-safety-efficacy-and-practical-application
#10
REVIEW
Jason C Wong, Aselle Barak
Dry eye disease (DED) is a common condition that affects mainly older individuals and women. It is characterized by reduced tear production and increased tear evaporation. Symptoms include burning, irritation, tearing, and blurry vision. This paper reviews key trials of various new DED treatments, including their mechanism of action, study outcomes, safety, and efficacy. The paper also includes a critical assessment of the trial's validity and potential pharmacy applications of these new treatments. The literature search was conducted through PubMed, the Cochrane Central Register of Controlled Trials, and Google Scholar...
January 23, 2024: Pharmacy (Basel, Switzerland)
https://read.qxmd.com/read/38371479/effect-of-dulaglutide-in-promoting-abstinence-during-smoking-cessation-12-month-follow-up-of-a-single-centre-randomised-double-blind-placebo-controlled-parallel-group-trial
#11
JOURNAL ARTICLE
Hualin Lüthi, Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Nica Jeanloz, Tanja Vukajlovic, Katja Bologna, Michelle Steinmetz, Cemile Bathelt, Clara O Sailer, Mirjam Laager, Deborah R Vogt, Lars G Hemkens, Benjamin Speich, Sandrine A Urwyler, Jill Kühne, Fabienne Baur, Linda N Lutz, Tobias E Erlanger, Mirjam Christ-Crain, Bettina Winzeler
BACKGROUND: Smoking cessation is challenging, despite making use of established smoking cessation therapies. Preclinical studies and one clinical pilot study suggest the antidiabetic drug glucagon-like peptide-1 (GLP-1) analogue to modulate addictive behaviours and nicotine craving. Previously, we reported the short-term results of a randomised, double-blind, placebo-controlled trial. Herein we report long-term abstinence rates and weight developments after 24 and 52 weeks. METHODS: This single-centre, randomised, double-blind, placebo-controlled, parallel group trial was done at the University Hospital Basel in Switzerland...
February 2024: EClinicalMedicine
https://read.qxmd.com/read/38369951/genetic-prediction-of-smoking-cessation-medication-side-effects-a-genome-wide-investigation-of-abnormal-dreams-on-varenicline
#12
JOURNAL ARTICLE
Meghan J Chenoweth, Yong Jae Kim, Nikki L Nollen, Larry W Hawk, Martin C Mahoney, Caryn Lerman, Jo Knight, Rachel F Tyndale
Varenicline, the most efficacious smoking cessation monotherapy, produces abnormal dreams. Although genetic contributions to varenicline-associated nausea and cessation have been identified, the role of genetics in abnormal dreams is unknown. We conducted a genomewide association study (GWAS) of abnormal dreams in 188 European ancestry smokers treated with varenicline (NCT01314001). Additive genetic models examined the likelihood of experiencing abnormal dreams 2 weeks following varenicline initiation...
February 19, 2024: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38366914/influence-of-sleep-quality-on-lapse-to-alcohol-use-during-a-quit-attempt
#13
RANDOMIZED CONTROLLED TRIAL
Wave-Ananda Baskerville, Erica N Grodin, Lara A Ray
AIMS: Sleep problems are common among individuals with alcohol use disorder (AUD) and is often associated with a heightened relapse risk. The present study examines the relationship between sleep and alcohol use among individuals with current AUD during a 6-day quit attempt as part of a medication study. METHODS: The current study is a secondary analysis of a medication trial for individuals with AUD. Individuals with AUD (N = 53, 26 females) were randomized to active medication or matched placebo...
January 17, 2024: Alcohol and Alcoholism
https://read.qxmd.com/read/38336930/individual-variations-in-motives-for-nicotine-self-administration-in-male-rats-evidence-in-support-for-a-precision-psychopharmacology
#14
JOURNAL ARTICLE
Vernon Garcia-Rivas, Jean-François Fiancette, Jessica Tostain, Giulia de Maio, Matias Ceau, Jean-François Wiart, Jean-Michel Gaulier, Véronique Deroche-Gamonet
The significant heterogeneity in smoking behavior among smokers, coupled with the inconsistent efficacy of approved smoking cessation therapies, supports the presence of individual variations in the mechanisms underlying smoking. This emphasizes the need to shift from standardized to personalized smoking cessation therapies. However, informed precision medicine demands precision fundamental research. Tobacco smoking is influenced and sustained by diverse psychopharmacological interactions between nicotine and environmental stimuli...
February 9, 2024: Translational Psychiatry
https://read.qxmd.com/read/38321910/nitrosamines-ich-q3a-q3e-global-substance-registration-system-gsrs-n-nitroso-dimethyl-amine-ndma-drug-substance-life-cycle
#15
JOURNAL ARTICLE
Darshan Bhirud, Gyan Agrawal, Harshil Shah, Artiben Patel, Mahesh B Palkar, Sankha Bhattacharya, Bhupendra G Prajapati
Since their discovery in valsartan-containing drugs, nitrosamine impurities have emerged as a significant safety problem in pharmaceutical products, prompting extensive recalls and suspensions. Valsartan, candesartan, irbesartan, olmesartan, and other sartans have been discovered to have additional nitrosamine impurities, such as N-nitroso-N-methyl-4-aminobutyric acid (NMBA), N-nitroso-Di-isopropyl amine (NDIPA), N-nitroso-Ethyl-Isopropyl amine (NEIPA), and N-nitroso-Diethyl amine (NDEA). Concerns about drug safety have grown in response to reports of nitrosamine contamination in pharmaceuticals, such as pioglitazone, rifampin, rifapentine, and varenicline...
February 6, 2024: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/38285562/efficacy-of-electronic-cigarettes-vs-varenicline-and-nicotine-chewing-gum-as-an-aid-to-stop-smoking-a-randomized-clinical-trial
#16
JOURNAL ARTICLE
Hao-Xiang Lin, Zhao Liu, Peter Hajek, Wan-Tong Zhang, Yuan Wu, Bao-Chen Zhu, Hai-Hua Liu, Qiu Xiang, Yan Zhang, Shu-Bin Li, Francesca Pesola, Ying-Ying Wang
IMPORTANCE: Electronic cigarettes (ECs) are often used by smokers as an aid to stopping smoking, but evidence is limited regarding their efficacy compared with nicotine replacement therapy (NRT), and no evidence is available on how their efficacy compares with that of varenicline. OBJECTIVE: To evaluate whether ECs are superior to NRT and noninferior to varenicline in helping smokers quit. DESIGN, SETTING, AND PARTICIPANTS: This was a randomized clinical trial conducted at 7 sites in China and including participants who were smoking at least 10 cigarettes per day and motivated to quit, not using stop-smoking medications or EC, and willing to use any of the study products...
January 29, 2024: JAMA Internal Medicine
https://read.qxmd.com/read/38285292/is-abstinence-from-alcohol-and-smoking-associated-with-less-anxiety-and-depressive-symptoms-among-people-with-hiv
#17
JOURNAL ARTICLE
Christina E Freibott, Breanne E Biondi, Sowmya R Rao, Elena Blokhina, Julianne N Dugas, Gregory Patts, Sally Bendiks, Evgeny Krupitsky, Natalie E Chichetto, Jeffrey H Samet, Matthew S Freiberg, Michael D Stein, Hilary A Tindle
Achieving abstinence from alcohol, tobacco, or both may improve mental health, but is understudied in people with HIV (PWH). The St PETER HIV randomized clinical trial compared varenicline, cytisine, and nicotine replacement therapy on alcohol and smoking behavior among 400 PWH in Russia. The primary exposure was thirty-day point prevalence abstinence (PPA) from (1) alcohol, (2) smoking, (3) both, or (4) neither and was assessed at 1, 3, 6 and 12-months as were the study outcomes of anxiety (GAD-7) and depressive (CES-D) symptoms...
January 29, 2024: AIDS and Behavior
https://read.qxmd.com/read/38264360/gender-differences-in-weight-gain-during-attempted-and-successful-smoking-cessation-on-dulaglutide-treatment-a-predefined-secondary-analysis-of-a-randomised-trial
#18
JOURNAL ARTICLE
Fabienne Baur, Cihan Atila, Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Cemile Bathelt, Mirjam Christ-Crain, Bettina Winzeler
BACKGROUND: Women seem to have more difficulty quitting smoking than men. This is particularly concerning as smoking puts women at a higher risk of developing smoking-associated diseases. Greater concerns about postcessation weight gain in women have been postulated as a possible explanation. METHODS: Predefined secondary analysis of a placebo-controlled, double-blind, parallel-group, superiority randomised trial including 255 adults who smoke daily (155 women, 100 men)...
December 2023: BMJ nutrition, prevention & health
https://read.qxmd.com/read/38246782/-cost-effectiveness-of-pharmaceutical-smoking-cessation-intervention-in-china-primary-cancer-prevention
#19
JOURNAL ARTICLE
P Y Sun, Y T Xie, R R Qie, H Huang, Z L Hu, M Y Wu, Q Yan, C R Zhu, J F Shi, K Y Zou, Y W Zhang
Objectives: To evaluate the cost-effectiveness of typical pharmaceutical smoking cessation intervention strategies in China in the context of primary cancer prevention. Methods: Markov cohort simulation models were established to simulate the burden of 12 smoking caused cancer, including lung cancer, oral cancer, nasopharyngeal cancer, laryngeal cancer, esophageal cancer, gastric cancer, pancreatic cancer, liver cancer, kidney cancer, bladder cancer, cervical cancer, and acute myeloid leukemia. Taking incremental cost effectiveness ratio (ICER) as the main indicator, the model sets one year as the cycling period for 50 periods and simulates the cohort of 10 000 thirty-five-year-old current smokers with various smoking cessation strategies...
January 23, 2024: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://read.qxmd.com/read/38239268/bupropion-and-varenicline-administration-reversed-depressive-behavior-induced-by-acetamiprid-exposure-in-mice-the-role-of-nachrs-in-depression
#20
JOURNAL ARTICLE
Azadeh Mesripour, Leila Soltani, Mehdi Aliomrani
Acetamiprid (ACE), is a popular neonicotinoid pesticide, that has a high affinity for mammalian nicotinic acetylcholine receptors (nAChRs). Therefore, ACE might induce depressive effects by perturbing the cholinergic system in mammalian. The aim of this study was to evaluate the effects of ACE exposure on depressive-like behaviors and grip strength (GS) in mice. Also the possible role of nAChR activation in depression was assessed by varenicline, and bupropion. Male Swiss mice (27 ± 2 g) were daily exposed to ACE by gavage (0...
February 2024: Toxicology Research
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