keyword
MENU ▼
Read by QxMD icon Read
search

Varenicline

keyword
https://www.readbyqxmd.com/read/28640564/-design-and-user-testing-of-a-decision-aid-comparing-medications-for-smoking-cessation
#1
Julian Jakob, Jacques Cornuz, Reto Auer, Isabelle Jacot Sadowski, Regula Cardinaux, Kevin Selby
Medications for smoking cessation, such as nicotine replacement, bupropion and varenicline have comparable efficacy, but present different advantages and drawbacks, making patient-specific preferences important when choosing a medication for smoking cessation. Through 3 PDCA cycles (Plan-Do-Check-Act), we developed and user-tested a decision aid for use during consultations. It contains the most relevant information for choosing a smoking cessation medication and is freely available online. The methodology used for its development could be employed for other decision aids for preference-sensitive decisions...
June 7, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28636795/cancer-related-disease-factors-and-smoking-cessation-treatment-analysis-of-an-ongoing-clinical-trial
#2
Allison J Carroll, Anna K Veluz-Wilkins, Sonja Blazekovic, Ravi Kalhan, Frank T Leone, E Paul Wileyto, Robert A Schnoll, Brian Hitsman
OBJECTIVE: Smoking cessation treatment should be an important aspect of cancer care. In this study, we evaluated whether cancer-related disease factors adversely influence smoking cessation treatment. METHODS: Smokers with cancer (within 5 years of diagnosis, any tumor site) were recruited for an ongoing trial of varenicline for smoking cessation. Disease factors, assessed at baseline, included tumor site, cancer treatment, time since diagnosis, and health-related quality of life (HRQOL)...
June 21, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28624760/how-do-smoking-cessation-medicines-compare-with-respect-to-their-neuropsychiatric-safety-a-protocol-for-a-systematic-review-network-meta-analysis-and-cost-effectiveness-analysis
#3
Kyla H Thomas, Deborah Caldwell, Michael N Dalili, David Gunnell, Marcus R Munafò, Matt Stevenson, Nicky J Welton
INTRODUCTION: Cigarette smoking is one of the leading causes of early death in the UK and worldwide. Public health guidance recommends the use of varenicline, bupropion and nicotine replacement therapy (NRT) as smoking cessation aids in the UK. Additionally, the first electronic cigarette has been licensed for use as a smoking cessation medicine. However, there are ongoing concerns about the safety of these medicines. We present a protocol for a systematic review and network meta-analysis (NMA) to determine how these smoking cessation medicines compare to each other with respect to their neuropsychiatric safety in adult smokers...
June 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28617959/varenicline-reduces-alcohol-intake-during-repeated-cycles-of-alcohol-reaccess-following-deprivation-in-alcohol-preferring-p-rats
#4
Janice C Froehlich, Emily R Nicholson, Julian E Dilley, Nick J Filosa, Logan C Rademacher, Teal N Smith
BACKGROUND: Most alcoholics experience periods of voluntary alcohol abstinence or imposed alcohol deprivation followed by a return to alcohol drinking. The current study examined whether varenicline (VAR) reduces alcohol intake during a return to drinking after periods of alcohol deprivation in rats selectively bred for high alcohol drinking (the alcohol preferring or "P" rats). METHODS: Alcohol-experienced P rats were given 24-hour access to food and water and scheduled access to alcohol (15% and 30% v/v) for 2 h/d...
June 15, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28605678/trends-in-utilization-of-smoking-cessation-agents-before-and-after-the-passage-of-fda-boxed-warning-in-the-united-states
#5
Drishti Shah, Anuj Shah, Xi Tan, Usha Sambamoorthi
BACKGROUND: In 2009, the FDA required a black box warning (BBW) on bupropion and varenicline, the two commonly prescribed smoking cessation agents due to reports of adverse neuropsychiatric events. We investigated if there was a decline in use of bupropion and varenicline after the BBW by comparing the percent using these medications before and after BBW. METHODS: We conducted a retrospective observational study using data from the Medical Expenditure Panel Survey from 2007 to 2014...
May 18, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28600734/effects-of-varenicline-on-alcohol-cue-reactivity-in-heavy-drinkers
#6
Walter Roberts, Emily L R Harrison, Sherry A McKee
RATIONALE: Clinical trials and human laboratory studies have established that varenicline can reduce rates of alcohol use among heavy drinkers. Less is known about the mechanisms by which varenicline has this effect on drinking behavior. Reactivity to alcohol cues is often cited as the primary cause of relapse among those being treated for alcohol use disorder, and several front-line treatments for alcohol use disorder work, at least in part, by minimizing cue-induced alcohol craving...
June 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28595356/treatment-with-bupropion-and-varenicline-for-smoking-cessation-and-the-risk-of-acute-cardiovascular-events-and-injuries-a-swedish-case-crossover-study
#7
Joel Monárrez-Espino, Maria Rosaria Galanti, Jenny Hansson, Imre Janszky, Karin Söderberg, Jette Möller
Introduction: Bupropion and varenicline are non-nicotine medications used for smoking cessation that mitigate craving and withdrawal symptoms. We aim to investigate whether these drugs increase the risk of selected acute adverse outcomes when used in medical practice. Methods: Population-based case-crossover design using data from Swedish health and administrative registers. Adult individuals diagnosed with acute myocardial infarction, stroke, suicide, suicide attempt, fall injury, or that suffered a road traffic crash from 01...
June 8, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28589175/secondary-ammonium-agonists-make-dual-cation-%C3%AF-interactions-in-%C3%AE-4%C3%AE-2-nicotinic-receptors
#8
Michael R Post, Gabrielle S Tender, Henry A Lester, Dennis A Dougherty
A cation-π interaction between the ammonium group of an agonist and a conserved tryptophan termed TrpB is a near universal feature of agonist binding to nicotinic acetylcholine receptors (nAChRs). TrpB is one of five residues that form the aromatic box of the agonist binding site, and for the prototype agonists ACh and nicotine, only TrpB makes a functional cation-π interaction. We report that, in addition to TrpB, a significant cation-π interaction is made to a second aromatic, TyrC2, by the agonists metanicotine, TC299423, varenicline, and nornicotine...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28578610/a-pilot-study-of-tobacco-screening-and-referral-for-smoking-cessation-program-among-hiv-infected-patients-in-france
#9
Jean-Jacques Parienti, Zine Merzougui, Arnaud de la Blanchardière, Sylvie Dargère, Philippe Feret, Béatrice Le Maitre, Renaud Verdon
BACKGROUND: The prevalence of tobacco smoking is high among patients living with HIV, supporting the need for effective targeted interventions. MATERIALS AND METHODS: All current smokers at our outpatient HIV clinic were invited to participate in a smoking cessation program. RESULTS: Of the 716 patients living with HIV, 280 (39%) reported active smoking and were younger, more recently HIV infected and more frequently infected due to intravenous drug use (IDU)...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28569519/concurrent-varenicline-and-prolonged-exposure-for-patients-with-nicotine-dependence-and-ptsd-a-randomized-controlled-trial
#10
Edna B Foa, Anu Asnaani, David Rosenfield, Laurie J Zandberg, Peter Gariti, Patricia Imms
BACKGROUND: Prevalence of smoking among individuals with posttraumatic stress disorder (PTSD) is disproportionately high, and PTSD is associated with especially poor response to smoking cessation treatment. OBJECTIVE: The current study examined whether integrating treatments for smoking cessation (varenicline plus smoking cessation counseling; VARCC) and PTSD (prolonged exposure therapy; PE) enhances smoking outcomes among smokers diagnosed with PTSD. METHOD: 142 adults with nicotine dependence (ND) and PTSD were randomized to a treatment program consisting of varenicline, smoking cessation counseling, and PE (VARCC + PE) or to VARCC only...
June 1, 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28556464/tobacco-harms-nicotine-pharmacology-and-pharmacologic-tobacco-cessation-interventions-for-women
#11
REVIEW
L Kim Baraona, Dawn Lovelace, Julie L Daniels, Linda McDaniel
Firsthand and secondhand tobacco use is linked to a multitude of harmful illnesses, adverse perinatal outcomes, and death. Cessation attempts among women may be hampered by their unique biologic response to nicotine. Current research has revealed epigenetic changes from intrauterine nicotine exposure that have intergenerational consequences. Multiple studies have demonstrated the efficacy of various pharmacologic tobacco cessation interventions in conjunction with behavioral counseling. Based on this evidence, the US Preventative Services Task Force (USPSTF) 2015 guideline recommends pharmacologic therapy for all nonpregnant persons who smoke in addition to behavioral counseling...
May 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28553407/sleep-disturbance-during-smoking-cessation-withdrawal-or-side-effect-of-treatment
#12
Rebecca L Ashare, Caryn Lerman, Rachel F Tyndale, Larry W Hawk, Tony P George, Paul Cinciripini, Robert A Schnoll
INTRODUCTION: The nicotine-metabolite ratio (NMR) predicts treatment response and is related to treatment side effect severity. Sleep disturbance may be one important side effect, but understanding sleep disturbance effects on smoking cessation is complicated by the fact that nicotine withdrawal also produces sleep disturbance. AIMS: To evaluate the effects of withdrawal and treatment side effects on sleep disturbance. METHODS: This is a secondary analysis of data from a clinical trial (Lerman et al...
June 2017: Journal of Smoking Cessation
https://www.readbyqxmd.com/read/28550660/achieving-smoking-cessation-in-individuals-with-schizophrenia-special-considerations
#13
REVIEW
Corinne Cather, Gladys N Pachas, Kristina M Cieslak, A Eden Evins
Premature mortality due to cardiovascular disease in those with schizophrenia is the largest lifespan disparity in the US and is growing; adults in the US with schizophrenia die, on average, 28 years earlier than those in the general population. The rate of smoking prevalence among individuals with schizophrenia is estimated to be from 64 to 79%. Smokers with schizophrenia have historically been excluded from most large nicotine-dependence treatment studies. However, converging evidence indicates that a majority of smokers with schizophrenia want to quit smoking, and that available pharmacotherapeutic smoking cessation aids are well tolerated by this population of smokers and are effective when combined with behavioral treatment...
June 2017: CNS Drugs
https://www.readbyqxmd.com/read/28549278/effects-of-varenicline-and-nicotine-replacement-therapy-on-arterial-elasticity-endothelial-glycocalyx-and-oxidative-stress-during-a-3-month-smoking-cessation-program
#14
Ignatios Ikonomidis, Margarita Marinou, Dimitrios Vlastos, Kallirhoe Kourea, Ioanna Andreadou, Nikolaos Liarakos, Helen Triantafyllidi, George Pavlidis, Elias Tsougos, John Parissis, John Lekakis
BACKGROUND AND AIMS: The effects of medically-aided smoking cessation on vascular function and oxidative stress are not fully clarified. METHODS: One hundred eighty-eight current smokers were randomized to varenicline or nicotine replacement treatment (NRT) for a 3-month period. We assessed: (a) augmentation index (Aix) and pulse wave velocity (PWV); (b) perfusion boundary region (PBR) of sublingual microvasculature (range:5-25 μm), an index of the endothelial glycocalyx thickness, using Sideview, Darkfield imaging; (c) the exhaled CO; and (d) the malondialdehyde (MDA) and protein carbonyls (PC) plasma levels, as markers of oxidative stress, at baseline and after 3 and 12 months...
May 13, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28549161/cigarette-smoking-cessation-intervention-for-buprenorphine-treatment-patients
#15
Sharon M Hall, Gary Humfleet, James Gasper, Kevin L Delucchi, David Hersh, Joseph Guydish
Introduction: Patients receiving Medication Assisted Therapy (MAT) for opioid use disorder have high cigarette smoking rates. Cigarette smoking interventions have had limited success. We evaluated an intervention to increase cigarette abstinence rates in patients receiving buprenorphine-assisted therapy. Methods: Cigarette smokers (N=175; 78% male; 69% Caucasian; 20% Hispanic), recruited from a buprenorphine clinic were randomly assigned to either an extended innovative system intervention (E-ISI) or to Standard Treatment Control (STC)...
May 26, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28525877/functional-network-connectivity-predicts-treatment-outcome-during-treatment-of-nicotine-use-disorder
#16
Claire E Wilcox, Vince D Calhoun, Srinivas Rachakonda, Eric D Claus, Rae A Littlewood, Jessica Mickey, Pamela B Arenella, Kent E Hutchison
Altered resting state functional connectivity (rsFC) and functional network connectivity (FNC), which is a measure of coherence between brain networks, may be associated with nicotine use disorder (NUD). We hypothesized that higher connectivity between insula and 1) dorsal anterior cingulate cortex (dACC) and 2) dorsolateral prefrontal cortex (dlPFC) would predict better treatment outcomes. We also performed an exploratory analysis of the associations between FNC values between additional key frontal and striatal regions and treatment outcomes...
April 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28522745/randomised-controlled-trial-of-stand-alone-tailored-emails-for-smoking-cessation
#17
J Lee Westmaas, Jeuneviette Bontemps-Jones, Peter S Hendricks, Jihye Kim, Lorien C Abroms
INTRODUCTION: Digital technology has created opportunities for delivering smoking cessation assistance at the population level. However, the efficacy of sending multiple, automated, tailored emails providing motivation, support and information for quitting is unknown. METHODS: Smokers planning to quit (n=1070) were randomly assigned to (1) 27 tailored cessation emails (deluxe email group (DEG)), (2) 3 to 4 tailored emails with links to downloadable booklets (basic email group (BEG)) or (3) a single non-tailored email (single email group (SEG))...
May 18, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28521015/changes-in-alcohol-consumption-during-a-stop-smoking-attempt-and-differences-between-smokers-using-nicotine-replacement-and-smokers-using-varenicline
#18
Dunja Przulj, Peter Hajek, Sarah Snuggs, Hayden McRobbie
Introduction: Little is known about effects of smoking cessation on alcohol consumption. Varenicline reduces enjoyment of smoking and cigarette consumption and may also reduce enjoyment and consumption of alcohol. We conducted the first prospective examination of the effects of stopping smoking on alcohol enjoyment and consumption, and compared clients using varenicline and clients using nicotine replacement treatment (NRT). Methods: Audit of records from clients undergoing routine smoking cessation treatment inthree stop-smoking services in London, UK...
May 17, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28505296/varenicline-is-associated-with-a-modest-limitation-in-weight-gain-in-smokers-after-smoking-cessation-a-meta-analysis
#19
Yanxin Sun, Wenhou Duan, Xin Meng, Huijie Li, Chongqi Jia
Objective: To assess the effect of treatment on limiting weight gain in abstainers using and not using varenicline and during the nontreatment phase. Methods: The PubMed, Medline, EMBASE and Cochrane Library databases were searched to identify relevant studies published in English or Chinese. A meta-analysis was performed to calculate pooled weighted mean differences (WMDs) in weight gain in smokers after smoking cessation between varenicline and control groups and their corresponding 95% CIs...
May 15, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28500373/effects-of-varenicline-versus-transdermal-nicotine-replacement-therapy-on-cigarette-demand-on-quit-day-in-individuals-with-substance-use-disorders
#20
Cara M Murphy, James MacKillop, Rosemarie A Martin, Jennifer W Tidey, Suzanne M Colby, Damaris J Rohsenow
RATIONALE: Cigarette demand is a behavioral economic measure of the relative value of cigarettes. Decreasing the value of cigarette reinforcement may help with quitting smoking. OBJECTIVES: This study aimed to evaluate the effects of initial use of varenicline (VAR) versus nicotine replacement therapy (NRT) on demand for cigarettes on quit day among smokers with substance use disorders (SUD) and to determine whether reduced demand was associated with subsequent abstinence from smoking at 1 and 3 months...
May 13, 2017: Psychopharmacology
keyword
keyword
77072
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"