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https://www.readbyqxmd.com/read/29049178/evaluation-of-smoking-cessation-intervention-in-patients-with-chronic-diseases-in-smoking-cessation-clinics
#1
Changxi Zhou, Lei Wu, Qinghui Liu, Huaijie An, Bin Jiang, Fan Zuo, Li Zhang, Yao He
This study aimed to evaluate the effects of psychological intervention and psychological plus drug intervention on smoking cessation among male smokers with single chronic diseases.A total of 509 male smokers were divided into psychological group (n = 290) and psychological plus drugs (n = 219) groups according to their will. The physicians provided free individual counseling and follow-up interviews with brief counseling for all the subjects. In addition to mental intervention, patients in psychological plus drug group also received bupropion hydrochloride or varenicline tartrate to quit smoking...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048184/association-of-nicotine-metabolism-and-sex-with-relapse-following-varenicline-and-nicotine-replacement-therapy
#2
Anaïs Glatard, Maria Dobrinas, Mehdi Gholamrezaee, Rubin Lubomirov, Jacques Cornuz, Chantal Csajka, Chin B Eap
Nicotine is metabolized into cotinine and then into trans-3'-hydroxycotinine, mainly by cytochrome P450 2A6. Recent studies reported better effectiveness of varenicline in women and in nicotine normal metabolizers phenotypically determined by nicotine-metabolite ratio. Our objective was to study the influence of nicotine-metabolite ratio, CYP2A6 genotype and sex on the response to nicotine replacement therapy and varenicline. Data were extracted from a longitudinal study which included smokers participating in a smoking cessation program...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29046149/schizophrenia-and-nicotine-dependence-what-psychopharmacological-treatment-options-are-available-for-the-duo-perturbationes
#3
Yoong Mei Theng, Suzaily Wahab, Noor Alaudin Wahab, Hatta Sidi, Srijit Das
Nicotine dependence has progressively become a foremost community health interest in the both developed and developing nations due to the economic burden and health-related problem. Smoking was significantly higher among patients with schizophrenia in comparison to the general population. Nicotine dependence is not only associated with public stress, but among patients with schizophrenia, smoking brings major challenges to the management. Nicotine may diminish the therapeutic efficacy of the bioavailability of the psychopharmacological agents in-vivo...
October 17, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29040555/the-effectiveness-of-varenicline-versus-nicotine-replacement-therapy-on-long-term-smoking-cessation-in-primary-care-a-prospective-cohort-study-of-electronic-medical-records
#4
Gemma M J Taylor, Amy E Taylor, Kyla H Thomas, Timothy Jones, Richard M Martin, Marcus R Munafò, Frank Windmeijer, Neil M Davies
Background: There is limited evidence about the effectiveness of varenicline and nicotine replacement therapy (NRT) for long-term smoking cessation in primary care, or whether the treatment effectiveness differs by socioeconomic position (SEP). Therefore, we estimated the long-term effectiveness of varenicline versus NRT (> 2 years) on smoking cessation, and investigated whether effectiveness differs by SEP. Methods: This is a prospective cohort study of electronic medical records from 654 general practices in England, within the Clinical Practice Research Datalink, using three different analytical methods: multivariable logistic regression, propensity score matching and instrumental variable analyses...
June 26, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29039714/causal-factors-of-increased-smoking-in-adhd-a-systematic-review
#5
Jan van Amsterdam, Bauke van der Velde, Mieke Schulte, Wim van den Brink
BACKGROUND: ADHD is a highly prevalent disorder and poses a risk for a variety of mental disorders and functional impairments into adulthood. One of the most striking comorbidities of ADHD is nicotine dependence. Youth diagnosed with ADHD are 2-3 times more likely to smoke than their peers without ADHD, initiate smoking earlier in life and progress more quickly and more frequently to regular use and dependence. Possible explanations for these increased risks are: (a) self-medication of ADHD symptoms with the stimulant nicotine; (b) ADHD symptoms like inattention and hyperactivity/impulsivity predispose for smoking initiation and impede smoking cessation; (c) peer pressure; and/or (d) common genetic or environmental determinants for ADHD and smoking...
October 17, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29038512/levels-of-exhaled-carbon-monoxide-measured-during-an-intervention-program-predict-1-year-smoking-cessation-a-retrospective-observational-cohort-study
#6
Huei-Guan Shie, Sheng-Wei Pan, Wen-Kuang Yu, Wei-Chih Chen, Li-Ing Ho, Hsin-Kuo Ko
Life-long smoking cessation is a critical public health objective, but it is difficult for numerous people. This study aimed to identify the independent predictors of 1-year abstinence in smokers motivated to quit and participating in an intervention program. This 6-year retrospective observational cohort study was conducted in smokers who participated in an intervention program. The exhaled carbon monoxide (CO) was sequentially measured on day 1, 8, 15, and 22 of the intervention program. The primary outcome measure was smoking status at 1 year of follow-up...
October 16, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29033021/-smoking-cessation-and-pregnancy
#7
M Underner, O Pourrat, J Perriot, G Peiffer, N Jaafari
Active and passive smoking during pregnancy induce several deleterious effects that may have a negative impact on pregnancy progress, fetus development and both mother and newborn health. Smoking cessation should be a rule for any woman as soon as the beginning of her pregnancy, or better in anticipation of a pregnancy when contraception is no more taken. Every caregiver must help every pregnant woman who smokes to quit smoking. Smoking cessation interventions in pregnant women must combine a psychological support (mainly with cognitive behavioral therapy) and nicotine replacement therapy, which can also be used during breast feeding...
October 9, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28975321/in-smokers-with-copd-neither-varenicline-nor-bupropion-was-linked-to-increased-cv-or-neuropsychiatric-risk-vs-nrt
#8
Catherine M Kress, Ngozi U Obi, Allan V Prochazka
No abstract text is available yet for this article.
September 19, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28952897/feasibility-and-preliminary-effectiveness-of-varenicline-for-treating-co-occurring-cannabis-and-tobacco-use
#9
Tangeria R Adams, Julia H Arnsten, Yuming Ning, Shadi Nahvi
Few studies have evaluated treatment for co-occurring cannabis and tobacco use. The objective of this pilot study was to evaluate the feasibility and preliminary effectiveness of varenicline for co-occurring cannabis and tobacco use. Participants who reported cannabis use on ≥5 days per week were recruited from an urban, outpatient opioid treatment program (OTP). Participants were randomized to either four weeks of standard OTP clinical care (SCC; medication-assisted treatment for opioid use disorder and individual behavioral counseling), followed by four weeks of SCC plus varenicline (SCC+VT), or to four weeks of SCC+VT followed by four weeks of SCC...
September 27, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28944993/evaluation-of-prolonged-exposure-to-varenicline-in-adult-rats-hematological-biochemical-and-anatomopathological-studies
#10
Julia Zaccarelli-Magalhães, Natalia Moreira, Thaisa Meira Sandini, Gabriel Ramos de Abreu, Angélica Maria Sánchez-Sarmiento, Esther Lopes Ricci, André Rinaldi Fukushima, Helenice de Souza Spinosa
Varenicline is a synthetic chemical substance produced from the alkaloid cytisine, used for smoking treatment, which acts as a partial agonist for α4β2 and α3β4 nicotinic cholinergic receptors and as a total agonist for α7 receptor. While there are studies regarding varenicline's non-smoking-related effects, as in treatment for drug dependence, there are no studies in the literature evaluating the long-term toxicity of varenicline through a physiological approach. Thus, the aim of this study was to evaluate possible toxicity through hematological, biochemical and anatomopathological parameters of prolonged exposure (30 days) to varenicline in rats...
September 25, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28942430/interventions-for-smoking-cessation-in-patients-admitted-with-acute-coronary-syndrome-review
#11
REVIEW
Omar M Chehab, Habib A Dakik
Tobacco smoking contributes to about six million deaths per year and is predicted to increase in the future. Several pharmacological interventions are used for smoking cessation. Trials using nicotine replacement therapy (NRT) in acute coronary syndrome (ACS) showed inconclusive results. Furthermore, three trials using bupropion in patients admitted with ACS failed to show improvement in smoking cessation compared with placebo. Interestingly, only one trial using varenicline was successful in achieving smoking abstinence in the acute setting...
September 23, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28936330/pyridine-sulfinates-as-general-nucleophilic-coupling-partners-in-palladium-catalyzed-cross-coupling-reactions-with-aryl-halides
#12
Tim Markovic, Benjamin N Rocke, David C Blakemore, Vincent Mascitti, Michael C Willis
Pyridine rings are ubiquitous in drug molecules; however, the pre-eminent reaction used to form carbon-carbon bonds in the pharmaceutical industry, the Suzuki-Miyaura cross-coupling reaction, often fails when applied to these structures. This phenomenon is most pronounced in 2-substituted pyridines, and results from the difficulty in preparing, the poor stability of, and low efficiency in reactions of pyridine-2-boronates. We demonstrate that by replacing these boronates with pyridine-2-sulfinates, a cross-coupling process of unrivalled scope and utility is realized...
June 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28925882/why-are-antidepressant-drugs-effective-smoking-cessation-aids
#13
Mohammed Shoaib, Yazead Buhidma
Before the advent of varenicline, antidepressant drugs were reported to exhibit better clinical efficacy than nicotine replacement therapy as smoking cessation aids. The most studied is bupropion, a clinically-effective antidepressant, the first to be marketed throughout Europe for smoking cessation. The mechanisms behind bupropion's efficacy as a smoking cessation compound remains unclear. Since depression and tobacco smoking have a high incidence of co-occurrence, this would implicate an underlying link between these two conditions...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28925657/varenicline-for-smoking-cessation
#14
Paul Crawford, Daniel Cieslak
No abstract text is available yet for this article.
September 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28924362/identification-and-characteristics-of-time-related-shifts-in-suicide-related-event-frequency-during-smoking-cessation-treatment-with-varenicline
#15
Hayato Akimoto, Haruna Wakiyama, Shinji Oshima, Akio Negishi, Kousuke Ohara, Sachihiko Numajiri, Mitsuyoshi Okita, Shigeru Ohshima, Naoko Inoue, Daisuke Kobayashi
Objectives: To survey time-related shifts in number of suicide-related events (SRE) during smoking cessation treatment with varenicline (VAR) in cases from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS), as well as the characteristics of these shifts. Methods: We isolated cases from the FAERS database involving VAR usage where SRE was reported as an adverse event (SRE+/VAR+ case) and established a histogram of SRE+/VAR+ case numbers per week. Furthermore, we focused on "cases reporting specific adverse events prior to drug usage start" using X-bar and R chart concepts...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28919445/cognitive-effects-of-labeled-addictolytic-medications
#16
REVIEW
Camille Noélie Pujol, Cecilia Paasche, Vincent Laprevote, Benoit Trojak, Pierre Vidailhet, Elisabeth Bacon, Laurence Lalanne
INTRODUCTION: Alcohol, tobacco, and illegal drug usage is pervasive throughout the world, and abuse of these substances is a major contributor to the global disease burden. Many pharmacotherapies have been developed over the last 50years to target addictive disorders. While the efficacy of these pharmacotherapies is largely recognized, their cognitive impact is less known. However, all substance abuse disorders are known to promote cognitive disorders like executive dysfunction and memory impairment...
September 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28912702/altered-white-matter-integrity-in-smokers-is-associated-with-smoking-cessation-outcomes
#17
Peiyu Huang, Zhujing Shen, Chao Wang, Wei Qian, Huan Zhang, Yihong Yang, Minming Zhang
Smoking is a significant cause of preventable mortality worldwide. Understanding the neural mechanisms of nicotine addiction and smoking cessation may provide effective targets for developing treatment strategies. In the present study, we explored whether smokers have white matter alterations and whether these alterations are related to cessation outcomes and smoking behaviors. Sixty-six smokers and thirty-seven healthy non-smokers were enrolled. The participants underwent magnetic resonance imaging scans and smoking-related behavioral assessments...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28894502/use-of-smoking-cessation-products-a-survey-of-patients-in-community-pharmacies
#18
Alan Phung, Lauren Luo, Noor Breik, Silvia Alessi-Severini
OBJECTIVES: At 17.3%, smoking rates in Manitoba continue to exceed the national average. In this province, a total health care spending of more than $200 million per year has been attributed to smoking. This study examined the use of smoking cessation agents, including nicotine replacement products and prescription medications, in a sample of smokers in the city of Winnipeg. METHODS: A simple multiple-choice questionnaire was administered to willing individuals attending 2 community pharmacies in Winnipeg, Manitoba...
September 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/28889258/moderators-of-smoking-cessation-outcomes-in-a-randomized-controlled-trial-of-varenicline-versus-placebo
#19
Rae A Littlewood, Eric D Claus, Claire E Wilcox, Jessica Mickey, Pamela B Arenella, Angela D Bryan, Kent E Hutchison
RATIONALE AND OBJECTIVE: Varenicline has gained a reputation as the optimal intervention for treatment resistant smokers, yet more than half of those who try it do not succeed. To better understand individual differences in the effectiveness of varenicline, this study evaluates the effectiveness of varenicline for smoking cessation in a double-blind, placebo-controlled, randomized clinical trial and examines the influence of psychological factors on treatment outcome. METHOD: Two hundred five cigarette smokers interested in quitting were randomly assigned to 12 weeks of varenicline or placebo...
September 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28885300/use-of-smoking-cessation-methods-among-patients-receiving-office-based-buprenorphine-maintenance-treatment
#20
Pooja A Shah, Chinazo O Cunningham, Mia T Brisbane, Joseph P DeLuca, Shadi Nahvi
OBJECTIVES: Provision of smoking-cessation treatment is limited in office-based buprenorphine maintenance treatment (BMT) settings. This study describes smoking and smoking-cessation behaviors among patients receiving office-based BMT. METHODS: Cross-sectional study of patients receiving office-based BMT at a community health center in the Bronx, NY. We interviewed patients assessing sociodemographic, and substance use and tobacco use characteristics, including methods used for smoking cessation...
September 6, 2017: Journal of Addiction Medicine
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