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Varenicline

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https://www.readbyqxmd.com/read/28342090/the-effect-of-varenicline-and-nicotine-patch-on-smoking-rate-and-satisfaction-with-smoking-an-examination-of-the-mechanism-of-action-of-two-pre-quit-pharmacotherapies
#1
Wenying Lu, Kate Chappell, Julia A E Walters, Glenn A Jacobson, Rahul Patel, Natalie Schüz, Stuart G Ferguson
OBJECTIVES: In recent years, there has been growing research interest in using nicotine replacement medications to aid smoking reduction prior to a quit attempt. Gaining a better understanding of how treatments influence smoking reduction may allow for better tailoring of treatments and, ultimately, better cessation outcomes. The objective of the current study was to test the effects of the pre-quit use of varenicline and nicotine patch on smoking rate and satisfaction with smoking. METHODS: All participants were required to attend up to five study visit sections...
March 24, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28337467/the-data-set-describing-cognitive-performance-after-varenicline-administration-in-a-3-choice-serial-reaction-time-task-in-rats
#2
Yu Ohmura, Hitomi Sasamori, Iku Tsutsui-Kimura, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshioka
The data shows attentional function, impulsivity, motivation, motor function, and motor activity in rats treated with varenicline, a stop-smoking aid. The data also shows these parameters in rats treated with varenicline after acute/chronic nicotine administration. Our interpretation and discussion of these data were described in the article "Varenicline Provokes Impulsive Action by Stimulating α4β2 Nicotinic Acetylcholine Receptors in the Infralimbic Cortex in a Nicotine Exposure Status-Dependent Manner" (Ohmura et al...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28326291/applying-a-new-theory-to-smoking-cessation-case-of-multi-theory-model-mtm-for-health-behavior-change
#3
Manoj Sharma, Jagdish Khubchandani, Vinayak K Nahar
Background: Smoking continues to be a public health problem worldwide. Smoking and tobacco use are associated with cardiovascular diseases that include coronary heart disease, atherosclerosis, cerebrovascular disease, and abdominal aortic aneurysm. Programs for quitting smoking have played a significant role in reduction of smoking in the United States. The smoking cessation interventions include counseling, nicotine replacement therapy, buproprion therapy, and varenicline therapy. The success rates with each of these approaches vary with clear need for improvement...
2017: Health Promotion Perspectives
https://www.readbyqxmd.com/read/28322496/comparison-of-hydrodynamically-closed-two-dimensional-capillary-electrophoresis-coupled-with-ultraviolet-detection-and-hydrodynamically-open-capillary-electrophoresis-hyphenated-with-mass-spectrometry-in-the-bioanalysis-of-varenicline
#4
Juraj Piešťanský, Katarína Maráková, Jaroslav Galba, Andrej Kováč, Peter Mikuš
Two capillary electrophoresis methods for monitoring renally excreted varenicline, a highly effective drug prescribed for smoking cessation, in human urine were developed and compared. A method combining capillary electrophoresis with mass spectrometry was proposed for the fast analysis of varenicline (analysis time up to 7 min). Here, mass spectrometry was a prerequisite for achieving high sensitivity and selectivity of the analysis suitable for the quantification of a 15 ng.mL(-1) level of varenicline in un-pretreated urine matrices...
March 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28319515/a-perioperative-smoking-cessation-intervention-with-varenicline-counseling-and-fax-referral-to-a-telephone-quitline-versus-a-brief-intervention-a-randomized-controlled-trial
#5
Jean Wong, Amir Abrishami, Sheila Riazi, Naveed Siddiqui, Eric You-Ten, Jennifer Korman, Sazzadul Islam, Xin Chen, Maged S M Andrawes, Peter Selby, David T Wong, Frances Chung
BACKGROUND: The effectiveness of perioperative interventions to quit smoking with varenicline has not been compared with brief interventions. Our objective was to determine the efficacy of a comprehensive smoking cessation program versus a brief intervention for smoking cessation. METHODS: In this prospective, multicenter study, 296 patients were randomized to participate in a smoking cessation program (one 10- to 15-minute counseling session, pharmacotherapy with varenicline, an educational pamphlet, and a fax referral to a telephone quitline); or brief advice and self-referral to a telephone quitline...
March 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28296573/the-adverse-effects-and-treatment-results-of-smoking-cessation-pharmacotherapy-during-fasting-non-fasting-state
#6
Sinem Iliaz, Seda Tural Onur, Mehmet Atilla Uysal, Efsun Gonca Uğur Chousein, Elif Tanriverdi, Belma Akbaba Bagci, Ayse Bahadir, Didem Gorgun Hattatoglu, Mediha Gonenc Ortakoylu, Sibel Yurt
BACKGROUND: Cigarette smoking is one of the most common addictions worldwide. Muslim smokers reduce the number of cigarettes they smoke during Ramadan due to the long fasting hours. OBJECTIVES: We aimed to share our experience in a smoking cessation clinic during Ramadan by analyzing the efficacy and adverse effects of once-daily dosing of bupropion or varenicline in a fasting group compared with conventional dosing in a non-fasting group. METHODS: We analyzed 57 patients who attended our smoking cessation clinic during Ramadan of 2014 and 2015, and at least one follow-up visit...
March 15, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28285208/predictors-of-tobacco-abstinence-in-outpatient-smokers-with-schizophrenia-or-bipolar-disorder-treated-with-varenicline-and-cognitive-behavioral-smoking-cessation-therapy
#7
Randi M Schuster, Corinne Cather, Gladys N Pachas, Haiyue Zhang, Kristina M Cieslak, Susanne S Hoeppner, David Schoenfeld, A Eden Evins
BACKGROUND: The estimated mortality gap between those with and without serious mental illness (SMI) is increasing, now estimated at 28years, which is largely due to smoking-related diseases. AIMS: We sought to identify predictors of 14-day continuous abstinence in stable outpatient smokers with SMI. METHOD: Adult smokers with schizophrenia spectrum (n=130) or bipolar disorder (n=23) were enrolled in a 12-week course of varenicline and cognitive-behavioral therapy for smoking cessation...
February 24, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28275830/benefits-of-varenicline-vs-bupropion-for-smoking-cessation-a-bayesian-analysis-of-the-interaction-of-reward-sensitivity-and-treatment
#8
Paul M Cinciripini, Charles E Green, Jason D Robinson, Maher Karam-Hage, Jeffrey M Engelmann, Jennifer A Minnix, David W Wetter, Francesco Versace
RATIONALE: We have shown that differences in the level of neural activation to stimuli associated with smoking vs. natural rewards, a biomarker related to reward sensitivity, predict treatment outcome. OBJECTIVES: This paper examined whether this biomarker moderates the impact of bupropion or varenicline on smoking cessation. METHODS: Prior to treatment randomization, smokers (N = 180) in a placebo-controlled trial using bupropion and varenicline completed event-related potential recording (late positive potential, LPP) while viewing pleasant (P), cigarette (C)-related, and other pictures...
March 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28275340/a-rat-drinking-in-the-dark-model-for-studying-ethanol-and-sucrose-consumption
#9
Joan Y Holgate, Masroor Shariff, Erica W H Mu, Selena Bartlett
Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models were developed for studying rodent binge-like consumption. Traditionally, IA2BC was used with rats and DID with mice. Recently, IA2BC was adapted to study mouse ethanol consumption. However, it is unknown whether DID is suitable for rats or if one rat model is more advantageous than another for studying binge-like consumption. Methods: Male Wistar rats consumed 20% ethanol or 5% sucrose using IA2BC or DID for 12 weeks...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28268112/taking-varenicline-for-smoking-cessation-a-rare-cause-of-pulmonary-thromboembolism-with-infarction
#10
Sun Hwa Lee, Seong Jong Yun, Seokyong Ryu, Seung Won Choi, Hye Jin Kim, Tae Kyug Kang, Sung Chan Oh, Suk Jin Cho
Varenicline (Champix®, Chantix®) is a partial agonist of the α4β2 nicotinic acetylcholine receptor (nAChR) and a full agonist of the α7 nAChR. It has been used for smoking cessation since 2006. Varenicline has been associated with adverse cardiovascular (CV) events, including myocardial infarction, which may be caused by activation of the α7 nAChR receptor that in turn stimulates parasympathetic output from the brainstem to the heart, release of catecholamines, and has a prothrombotic effect. However, among the adverse CV events, the issue related to the varenicline-induced pulmonary thromboembolism (PTE) has not being addressed...
February 28, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28264577/-centers-for-tobacco-dependent-in-the-czech-republic-in-2016
#11
Kamila Zvolská, Eva Králíková
This article sums up the evaluation of the intensive specialized treatment of tobacco dependence in the Czech Republic according to international guidelines and the ratified Framework Convention on Tobacco Control of the World Health Organization. 36 centers (100 %) were evaluated in 2016 and compared with the same survey from 2012.Most of the centers (24 of 36) are based at pulmonary clinics, opening hours for the smokers are on average 7 hours/week (0.5-40.0, SD ± 9, median 4). Average number of new patients is 55/year per center (2-449, SD ± 77...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28239942/extended-treatment-for-cigarette-smoking-cessation-a-randomized-control-trial
#12
Jennifer R Laude, Steffani R Bailey, Erin Crew, Ann Varady, Anna Lembke, Danielle McFall, Anna Jeon, Diana Killen, Joel D Killen, Sean P David
AIM: To test the potential benefit of extending cognitive-behavioral therapy (CBT) relative to not extending CBT on long-term abstinence from smoking. DESIGN: Two-group parallel randomised controlled trial. Patients were randomized to receive non-extended CBT (n = 111) or extended CBT (n = 112) following a 26-week open-label treatment. SETTING: Community clinic in the USA. PARTICIPANTS: 219 smokers (mean age: 43 years; mean cigarettes/day: 18)...
February 26, 2017: Addiction
https://www.readbyqxmd.com/read/28231626/default-mode-network-deactivation-to-smoking-cue-relative-to-food-cue-predicts-treatment-outcome-in-nicotine-use-disorder
#13
Claire E Wilcox, Eric D Claus, Vince D Calhoun, Srinivas Rachakonda, Rae A Littlewood, Jessica Mickey, Pamela B Arenella, Natalie Goodreau, Kent E Hutchison
Identifying predictors of treatment outcome for nicotine use disorders (NUDs) may help improve efficacy of established treatments, like varenicline. Brain reactivity to drug stimuli predicts relapse risk in nicotine and other substance use disorders in some studies. Activity in the default mode network (DMN) is affected by drug cues and other palatable cues, but its clinical significance is unclear. In this study, 143 individuals with NUD (male n = 91, ages 18-55 years) received a functional magnetic resonance imaging scan during a visual cue task during which they were presented with a series of smoking-related or food-related video clips prior to randomization to treatment with varenicline (n = 80) or placebo...
February 23, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28224877/-helping-people-to-give-up-smoking-efficacy-and-safety-of-smoking-cessation-interventions
#14
R C van de Graaf, O C P van Schayck
- This review evaluates the safety and efficacy of, smoking cessation interventions.- Behavioural counselling is the cornerstone of smoking cessation programmes.- This counselling can be supplemented with written self-help materials, telephone counselling and e-health tailored to individual patient preferences.- Behavioural counselling may be combined with pharmacotherapy for increased effectiveness. First choice is a combination of a nicotine patch and a nicotine lozenge or chewing gum, mainly because of the favourable side-effect profile...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28218695/electronic-cigarette-use-and-smoking-abstinence-in-japan-a-cross-sectional-study-of-quitting-methods
#15
Tomoyasu Hirano, Takahiro Tabuchi, Rika Nakahara, Naoki Kunugita, Yumiko Mochizuki-Kobayashi
The benefit of electronic cigarettes (e-cigarettes) in smoking cessation remains controversial. Recently, e-cigarettes have been gaining popularity in Japan, without evidence of efficacy on quitting cigarettes. We conducted an online survey to collect information on tobacco use, difficulties in smoking cessation, socio-demographic factors, and health-related factors in Japan. Among the total participants (n = 9055), 798 eligible persons aged 20-69 years who smoked within the previous five years were analyzed to assess the relationship between the outcome of smoking cessation and quitting methods used, including e-cigarettes, smoking cessation therapy, and unassisted...
February 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28216282/smoking-cessation-improves-cardiometabolic-risk-in-overweight-and-obese-subjects-treated-with-varenicline-and-dietary-counseling
#16
E Heggen, M Svendsen, S Tonstad
BACKGROUND AND AIM: Weight gain after stopping smoking potentially counteracts improvements in cardiometabolic risks. We investigated changes in metabolic syndrome (MetS) components and homeostasis assessment model insulin resistance (HOMA-IR) in smokers given dietary counseling during their quit attempt. METHODS AND RESULTS: Smokers (≥10 cigarettes/day) with BMI 25-40 kg/m(2) were randomized to a low-carbohydrate or low-fat diet and treated with a standard course of varenicline for 12 weeks...
January 4, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28215231/use-of-varenicline-in-smokeless-tobacco-cessation-influences-sleep-quality-and-dream-recall-frequency-but-not-dream-affect
#17
Francesca Polini, Rosastella Principe, Serena Scarpelli, Francesca Clementi, Luigi De Gennaro
OBJECTIVE: Varenicline (VCL) treatment has become popular as a part of smoking-cessation therapies, even though its possible implications in neuropsychiatric adverse events include abnormal sleep and nightmares. Our study is the first aimed at prospectively investigating changes in sleep and dream measures across such treatment by using a one week sleep diary and collecting dream recall (DR). METHODS: Thirty-eight smokers participated in two different effective smoking-cessation programs: 25 subjects received VCL, 13 subjects received nicotine replacement therapy (NRT)...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28207744/utilization-of-smoking-cessation-medication-benefits-among-medicaid-fee-for-service-enrollees-1999-2008
#18
Jennifer Kahende, Ann Malarcher, Lucinda England, Lei Zhang, Paul Mowery, Xin Xu, Varadan Sevilimedu, Italia Rolle
OBJECTIVE: To assess state coverage and utilization of Medicaid smoking cessation medication benefits among fee-for-service enrollees who smoked cigarettes. METHODS: We used the linked National Health Interview Survey (survey years 1995, 1997-2005) and the Medicaid Analytic eXtract files (1999-2008) to assess utilization of smoking cessation medication benefits among 5,982 cigarette smokers aged 18-64 years enrolled in Medicaid fee-for-service whose state Medicaid insurance covered at least one cessation medication...
2017: PloS One
https://www.readbyqxmd.com/read/28202387/varenicline-enhances-oxidized-ldl-uptake-by-increasing-expression-of-lox-1-and-cd36-scavenger-receptors-through-%C3%AE-7-nachr-in-macrophages
#19
Yuki Kanaoka, Mitsuhisa Koga, Keita Sugiyama, Kaoru Ohishi, Yasufumi Kataoka, Atsushi Yamauchi
Varenicline is a widely used and effective drug for smoking cessation. It is a partial agonist of the α4β2 nicotinic acetylcholine receptor (nAChR) and full agonist of α7 nAChR. We have reported that varenicline aggravates formation of atherosclerotic plaques through α7 nAChR in apolipoprotein E knockout mice. However, little is known about its effects on macrophages in atherosclerotic plaques. Here, we ascertained whether varenicline promotes oxidized low-density lipoprotein (oxLDL) uptake in mouse peritoneal macrophages in vitro and clarified its mechanism...
February 12, 2017: Toxicology
https://www.readbyqxmd.com/read/28185963/increased-network-centrality-as-markers-of-relapse-risk-in-nicotine-dependent-individuals-treated-with-varenicline
#20
Zhujing Shen, Peiyu Huang, Chao Wang, Wei Qian, Yihong Yang, Minming Zhang
Identifying smokers at high risk of relapse could improve the effectiveness of cessation therapies. Although altered regional brain function in smokers has been reported, whether the whole-brain functional organization differs smokers with relapse vulnerability from others remains unclear. Thus, the goal of this study is to investigate the baseline functional connectivity differences between relapsers and quitters. Using resting-state fMRI, we acquired images from 57 smokers prior to quitting attempts. After 12-week treatment with varenicline, smokers were divided into relapsers (n=36) and quitters (n=21) (quitter: continuously abstinent for weeks 9-12)...
April 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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