keyword
MENU ▼
Read by QxMD icon Read
search

Varenicline

keyword
https://www.readbyqxmd.com/read/28420644/smokers-and-postcessation-weight-gain-after-acute-coronary-syndrome
#1
Payam Dehghani, Bettina Habib, Sarah B Windle, Nathalie Roy, Wayne Old, François R Grondin, Iqbal Bata, Ayman Iskander, Claude Lauzon, Nalin Srivastava, Adam Clarke, Daniel Cassavar, Danielle Dion, Herbert Haught, Shamir R Mehta, Jean-François Baril, Charles Lambert, Mina Madan, Beth L Abramson, Mark J Eisenberg
BACKGROUND: Smoking cessation and weight management are recommended after acute coronary syndrome (ACS); however, little is known about the effects of smoking cessation on weight change after ACS. We aimed to assess the effect of smoking cessation after ACS on weight over a 12-month follow-up period. METHODS AND RESULTS: Data were prospectively collected from the EVITA (Evaluation of Varenicline in Smoking Cessation for Patients Post-Acute Coronary Syndrome) trial...
April 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28420395/characteristics-of-first-time-varenicline-users-a-cross-sectional-study-in-finnish-quitters
#2
Hanna E Tervonen, Juha H O Turunen, Christine L Baker, Juha Laine, Kari Linden
BACKGROUND: Varenicline is an efficacious medicine for smoking cessation (SC) but little is known about the characteristics of varenicline users. This study examined the characteristics of first-time (naïve) varenicline users in Finland and compared those who had previously used SC pharmacotherapy to those who were trying SC pharmacotherapy for the first time. METHODS: A cross-sectional survey was conducted in Finnish community pharmacies between February 2014 and January 2015...
April 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28414583/improved-depressive-symptoms-in-adults-with-schizophrenia-during-a-smoking-cessation-attempt-with-varenicline-and-behavioral-therapy
#3
Corinne Cather, Susanne Hoeppner, Gladys Pachas, Sarah Pratt, Eric Achtyes, Kristina M Cieslak, A Eden Evins
OBJECTIVE: Smoking prevalence rates are elevated in individuals with schizophrenia spectrum disorders (SSD) compared with the general population, with attendant disproportionate smoking-related morbidity and mortality. Pharmacotherapies that improve abstinence rates in this population are underutilized, partly due to concerns about neuropsychiatric safety, particularly for those with comorbid depression or prior suicide attempt. Prospective assessment of the psychiatric safety profile of varenicline in those with SSD is needed...
April 17, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28403462/medicaid-coverage-of-smoking-cessation-counseling-and-medication-is-underutilized-for-pregnant-women
#4
Taneisha S Scheuermann, Kimber P Richter, Lisette T Jacobson, Theresa I Shireman
Introduction: Policies to promote smoking cessation among Medicaid-insured pregnant women have the potential to assist a significant proportion of pregnant smokers. In 2010, Kansas Medicaid began covering smoking cessation counseling for pregnant smokers. Our aim was to evaluate the use of smoking cessation benefits provided to pregnant women as a result of the Kansas Medicaid policy change that provided reimbursement for physician-provided smoking cessation counseling. Methods: We examined Kansas Medicaid claims data to estimate rates of delivery of smoking cessation treatment to Medicaid-insured pregnant women in Kansas from fiscal year 2010 through 2013...
May 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28403383/neural-signatures-of-cognitive-flexibility-and-reward-sensitivity-following-nicotinic-receptor-stimulation-in-dependent-smokers-a-randomized-trial
#5
Elise Lesage, Sarah E Aronson, Matthew T Sutherland, Thomas J Ross, Betty Jo Salmeron, Elliot A Stein
Importance: Withdrawal from nicotine is an important contributor to smoking relapse. Understanding how reward-based decision making is affected by abstinence and by pharmacotherapies such as nicotine replacement therapy and varenicline tartrate may aid cessation treatment. Objective: To independently assess the effects of nicotine dependence and stimulation of the nicotinic acetylcholine receptor on the ability to interpret valence information (reward sensitivity) and subsequently alter behavior as reward contingencies change (cognitive flexibility) in a probabilistic reversal learning task...
April 12, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28398582/how-to-compare-instrumental-variable-and-conventional-regression-analyses-using-negative-controls-and-bias-plots
#6
Neil M Davies, Kyla H Thomas, Amy E Taylor, Gemma M J Taylor, Richard M Martin, Marcus R Munafò, Frank Windmeijer
There is increasing interest in the use of instrumental variable analysis to overcome unmeasured confounding in observational pharmacoepidemiological studies. This is partly because instrumental variable analyses are potentially less biased than conventional regression analyses. However, instrumental variable analyses are less precise, and regulators and clinicians find it difficult to interpret conflicting evidence from instrumental variable compared with conventional regression analyses. In this paper, we describe three techniques to assess which approach (instrumental variable versus conventional regression analyses) is least biased...
April 7, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28391535/discriminative-stimulus-properties-of-s-nicotine-a-drug-for-all-seasons
#7
John A Rosecrans, Richard Young
S(-)-Nicotine is the major pharmacologically active substance in tobacco and can function as an effective discriminative stimulus in both experimental animals and humans. In this model, subjects must detect and communicate the nicotine drug state versus the non-drug state. This review describes the usefulness of the procedure to study nicotine, presents a general overview of the model, and provides some relevant methodological details for the establishment of this drug as a stimulus. Once established, the (-)-nicotine stimulus can be characterized for dose response and time course effects...
April 9, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28376818/smokers-making-a-quit-attempt-using-e-cigarettes-with-or-without-nicotine-or-prescription-nicotine-replacement-therapy-impact-on-cardiovascular-function-isme-nrt-a-study-protocol
#8
Markos Klonizakis, Helen Crank, Anil Gumber, Leonie S Brose
BACKGROUND: The estimated number of cigarette smokers in the world is 1.3 billion, expected to rise to 1.7 billion by 2025, with 10 million smokers living in the U.K. Smoking is the leading, preventable death-cause worldwide, being responsible for almost 650,000 deaths in the E.U. annually. A combination of pharmacological interventions, including nicotine replacement therapy, bupropion and varenicline, and behavioural support is the most effective approach to smoking cessation. However, even the best methods have high relapse rates of approximately 75% within 6 months...
April 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28367632/subtle-differences-among-5-ht3ac-5-ht3ad-and-5-ht3ae-receptors-are-revealed-by-partial-agonists
#9
Kerry L Price, Yuri Hirayama, Sarah C R Lummis
5-HT3 receptors are members of the Cys-loop family of ligand-gated ion channels, and, like most members of this family, there are multiple subunits that can contribute to functional pentameric receptors. 5-HT3A and 5-HT3AB receptors have been extensively characterized, but there are few studies on 5-HT3AC, 5-HT3AD, and 5-HT3AE receptors. Here we explore the properties of a range of partial agonists at 5-HT3AC, 5-HT3AD, and 5-HT3AE receptors following expression in Xenopus oocytes. The data show that the characteristics of receptor activation differ in the different heteromeric receptors when they are challenged with 5-HT, m-chlorophenylbiguanide (mCPBG), varenicline, 5-fluorotryptamine (5-FT), or thymol...
April 3, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28365035/efficacy-of-varenicline-for-cigarette-reduction-before-quitting-in-japanese-smokers-a-subpopulation-analysis-of-the-reduce-to-quit-trial
#10
Masakazu Nakamura, Masaaki Abe, Masayuki Ohkura, Joan Treadow, Ching-Ray Yu, Peter W Park
PURPOSE: This prospective analysis of the Japanese subpopulation of the varenicline reduce to quit study was conducted to evaluate whether results for Japanese participants were consistent with the full study population. METHODS: Patients received varenicline or placebo for a 24-week treatment period (12-week smoking reduction phase then a 12-week smoking abstinence phase) followed by a 28-week nontreatment, follow-up phase. Participants were to reduce the daily number of cigarettes smoked by at least 50% by week 4 and by a further 50% by week 8, with the goal of achieving complete abstinence by week 12...
March 29, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28351203/effects-of-varenicline-on-alcohol-self-administration-and-craving-in-drinkers-with-depressive-symptoms
#11
Walter Roberts, Terril L Verplaetse, Kelly Moore, Lindsay Oberleitner, Marina R Picciotto, Sherry A McKee
Varenicline (VAR) is approved to aid in smoking cessation and has been shown to be effective for reducing alcohol consumption in heavy drinkers. Little is known, however, about treatment moderators that may influence efficacy. The current study reanalyzed data from a human laboratory study (Verplaetse et al., 2016) to determine whether VAR was more effective at reducing alcohol use among drinkers reporting symptoms of depression. Participants were 60 adults meeting DSM-IV criteria for alcohol use disorders ( n = 60) who were randomly assigned to receive VAR (1 mg/day, 2 mg/day) or placebo...
March 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28342090/the-effect-of-varenicline-and-nicotine-patch-on-smoking-rate-and-satisfaction-with-smoking-an-examination-of-the-mechanism-of-action-of-two-pre-quit-pharmacotherapies
#12
Wenying Lu, Kate Chappell, Julia A E Walters, Glenn A Jacobson, Rahul Patel, Natalie Schüz, Stuart G Ferguson
OBJECTIVES: In recent years, there has been growing research interest in using nicotine replacement medications to aid smoking reduction prior to a quit attempt. Gaining a better understanding of how treatments influence smoking reduction may allow for better tailoring of treatments and, ultimately, better cessation outcomes. The objective of the current study was to test the effects of the pre-quit use of varenicline and nicotine patch on smoking rate and satisfaction with smoking. METHODS: All participants were required to attend up to five study visit sections...
March 24, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28337467/the-data-set-describing-cognitive-performance-after-varenicline-administration-in-a-3-choice-serial-reaction-time-task-in-rats
#13
Yu Ohmura, Hitomi Sasamori, Iku Tsutsui-Kimura, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshioka
The data shows attentional function, impulsivity, motivation, motor function, and motor activity in rats treated with varenicline, a stop-smoking aid. The data also shows these parameters in rats treated with varenicline after acute/chronic nicotine administration. Our interpretation and discussion of these data were described in the article "Varenicline Provokes Impulsive Action by Stimulating α4β2 Nicotinic Acetylcholine Receptors in the Infralimbic Cortex in a Nicotine Exposure Status-Dependent Manner" (Ohmura et al...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28326291/applying-a-new-theory-to-smoking-cessation-case-of-multi-theory-model-mtm-for-health-behavior-change
#14
Manoj Sharma, Jagdish Khubchandani, Vinayak K Nahar
Background: Smoking continues to be a public health problem worldwide. Smoking and tobacco use are associated with cardiovascular diseases that include coronary heart disease, atherosclerosis, cerebrovascular disease, and abdominal aortic aneurysm. Programs for quitting smoking have played a significant role in reduction of smoking in the United States. The smoking cessation interventions include counseling, nicotine replacement therapy, buproprion therapy, and varenicline therapy. The success rates with each of these approaches vary with clear need for improvement...
2017: Health Promotion Perspectives
https://www.readbyqxmd.com/read/28322496/comparison-of-hydrodynamically-closed-two-dimensional-capillary-electrophoresis-coupled-with-ultraviolet-detection-and-hydrodynamically-open-capillary-electrophoresis-hyphenated-with-mass-spectrometry-in-the-bioanalysis-of-varenicline
#15
Juraj Piešťanský, Katarína Maráková, Jaroslav Galba, Andrej Kováč, Peter Mikuš
Two capillary electrophoresis methods for monitoring renally excreted varenicline, a highly effective drug prescribed for smoking cessation, in human urine were developed and compared. A method combining capillary electrophoresis with mass spectrometry was proposed for the fast analysis of varenicline (analysis time up to 7 min). Here, mass spectrometry was a prerequisite for achieving high sensitivity and selectivity of the analysis suitable for the quantification of a 15 ng/mL level of varenicline in un-pretreated urine matrices...
March 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28319515/a-perioperative-smoking-cessation-intervention-with-varenicline-counseling-and-fax-referral-to-a-telephone-quitline-versus-a-brief-intervention-a-randomized-controlled-trial
#16
Jean Wong, Amir Abrishami, Sheila Riazi, Naveed Siddiqui, Eric You-Ten, Jennifer Korman, Sazzadul Islam, Xin Chen, Maged S M Andrawes, Peter Selby, David T Wong, Frances Chung
BACKGROUND: The effectiveness of perioperative interventions to quit smoking with varenicline has not been compared with brief interventions. Our objective was to determine the efficacy of a comprehensive smoking cessation program versus a brief intervention for smoking cessation. METHODS: In this prospective, multicenter study, 296 patients were randomized to participate in a smoking cessation program (one 10- to 15-minute counseling session, pharmacotherapy with varenicline, an educational pamphlet, and a fax referral to a telephone quitline); or brief advice and self-referral to a telephone quitline...
March 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28296573/the-adverse-effects-and-treatment-results-of-smoking-cessation-pharmacotherapy-during-fasting-non-fasting-state
#17
Sinem Iliaz, Seda Tural Onur, Mehmet Atilla Uysal, Efsun Gonca Uğur Chousein, Elif Tanriverdi, Belma Akbaba Bagci, Ayse Bahadir, Didem Gorgun Hattatoglu, Mediha Gonenc Ortakoylu, Sibel Yurt
BACKGROUND: Cigarette smoking is one of the most common addictions worldwide. Muslim smokers reduce the number of cigarettes they smoke during Ramadan due to the long fasting hours. OBJECTIVES: We aimed to share our experience in a smoking cessation clinic during Ramadan by analyzing the efficacy and adverse effects of once-daily dosing of bupropion or varenicline in a fasting group compared with conventional dosing in a non-fasting group. METHODS: We analyzed 57 patients who attended our smoking cessation clinic during Ramadan of 2014 and 2015, and at least one follow-up visit...
March 15, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28285208/predictors-of-tobacco-abstinence-in-outpatient-smokers-with-schizophrenia-or-bipolar-disorder-treated-with-varenicline-and-cognitive-behavioral-smoking-cessation-therapy
#18
Randi M Schuster, Corinne Cather, Gladys N Pachas, Haiyue Zhang, Kristina M Cieslak, Susanne S Hoeppner, David Schoenfeld, A Eden Evins
BACKGROUND: The estimated mortality gap between those with and without serious mental illness (SMI) is increasing, now estimated at 28years, which is largely due to smoking-related diseases. AIMS: We sought to identify predictors of 14-day continuous abstinence in stable outpatient smokers with SMI. METHOD: Adult smokers with schizophrenia spectrum (n=130) or bipolar disorder (n=23) were enrolled in a 12-week course of varenicline and cognitive-behavioral therapy for smoking cessation...
February 24, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28275830/benefits-of-varenicline-vs-bupropion-for-smoking-cessation-a-bayesian-analysis-of-the-interaction-of-reward-sensitivity-and-treatment
#19
Paul M Cinciripini, Charles E Green, Jason D Robinson, Maher Karam-Hage, Jeffrey M Engelmann, Jennifer A Minnix, David W Wetter, Francesco Versace
RATIONALE: We have shown that differences in the level of neural activation to stimuli associated with smoking vs. natural rewards, a biomarker related to reward sensitivity, predict treatment outcome. OBJECTIVES: This paper examined whether this biomarker moderates the impact of bupropion or varenicline on smoking cessation. METHODS: Prior to treatment randomization, smokers (N = 180) in a placebo-controlled trial using bupropion and varenicline completed event-related potential recording (late positive potential, LPP) while viewing pleasant (P), cigarette (C)-related, and other pictures...
March 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28275340/a-rat-drinking-in-the-dark-model-for-studying-ethanol-and-sucrose-consumption
#20
Joan Y Holgate, Masroor Shariff, Erica W H Mu, Selena Bartlett
Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models were developed for studying rodent binge-like consumption. Traditionally, IA2BC was used with rats and DID with mice. Recently, IA2BC was adapted to study mouse ethanol consumption. However, it is unknown whether DID is suitable for rats or if one rat model is more advantageous than another for studying binge-like consumption. Methods: Male Wistar rats consumed 20% ethanol or 5% sucrose using IA2BC or DID for 12 weeks...
2017: Frontiers in Behavioral Neuroscience
keyword
keyword
77072
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"