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https://www.readbyqxmd.com/read/29781191/clinical-approach-to-vulvovaginal-cysts-and-abscesses-a-review
#1
REVIEW
Jessica De Bortoli, Prathima Chowdary, Payam Nikpoor, Emma Readman
Vulvovaginal cysts are a common problem for women, causing significant pain, discomfort and impact on quality of life. For clinicians, classifying and differentiating these cysts from each other and selecting appropriate management can be challenging, yet there is no integrated classification system and little literature that broadly summarises a clinical approach. We aimed to create a useful tool for clinicians by providing a detailed summary of various vulvovaginal cysts and abscesses with a clear novel classification system and hierarchy for diagnosis and management, to aid clinicians in this process...
May 21, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29778188/national-surveillance-plan-for-infectious-bovine-rhinotracheitis-ibr-in-autochthonous-italian-cattle-breeds-results-of-first-year-of-activity
#2
Carmen Maresca, Eleonora Scoccia, Annalisa Dettori, Andrea Felici, Roberta Guarcini, Stefano Petrini, Andrea Quaglia, Giovanni Filippini
Infectious bovine rhinotracheitis (IBR)/infectious pustular vulvovaginitis (IPV) caused by Bovine alphaherpesvirus 1 (BoHV-1) is a significant disease in domestic and wild cattle. In June 2015, the Ministry of Agriculture, Food and Forestry in Italy approved a national surveillance plan to control and eradicate IBR in beef cattle breeds. The objective of this study was to evaluate the results of the first year of the IBR voluntary surveillance plan in Italy. The aim of the plan is to eradicate IBR in all bovines recorded in the National Herd Book for Italian beef cattle breeds over six years...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29775695/pulsatilla-decoction-inhibits-candida-albicans-proliferation-and-adhesion-in-a-mouse-model-of-vulvovaginal-candidiasis-via-the-dectin-1-signaling-pathway
#3
Lilin Yang, Haiwang Wu, Weiyu Qiu, Longyi Guo, Xin Du, Qingying Yu, Jie Gao, Songping Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Pulsatilla decoction (PD) is a classical prescription in Traditional Chinese Medicine (TCM) and has been reported to have inhibitory effects on Candida albicans proliferation. STUDY AIM: To investigate the therapeutic effects of PD in the treatment of Vulvovaginal candidiasis (VVC) and elucidate the potential mechanism. MATERIALS AND METHODS: Female BALB/c mice (N=90) were randomized to six treatment groups, including the Control group, Model group, three PD groups and Fluconazole group which served as a positive control (20mg/kg weekly)...
May 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29755472/the-elusive-anti-candida-vaccine-lessons-from-the-past-and-opportunities-for-the-future
#4
REVIEW
Gloria Hoi Wan Tso, Jose Antonio Reales-Calderon, Norman Pavelka
Candidemia is a bloodstream fungal infection caused by Candida species and is most commonly observed in hospitalized patients. Even with proper antifungal drug treatment, mortality rates remain high at 40-50%. Therefore, prophylactic or preemptive antifungal medications are currently recommended in order to prevent infections in high-risk patients. Moreover, the majority of women experience at least one episode of vulvovaginal candidiasis (VVC) throughout their lifetime and many of them suffer from recurrent VVC (RVVC) with frequent relapses for the rest of their lives...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29752810/a-prospective-study-of-female-genital-chronic-graft-versus-host-disease-symptoms-signs-diagnosis-and-treatment
#5
Eva Smith Knutsson, Yvonne Björk, Anna-Karin Broman, Lotti Helström, Malin Nicklasson, Mats Brune, Karin Sundfeldt
INTRODUCTION: Female genital chronic graft-versus-host disease (cGvHD) is a complication of allogeneic hematopoietic cell transplantation (alloHCT) for blood malignancies. Unattended inflammation and fibrosis in the vulva and vagina may lead to total vaginal stenosis. The course and treatment of genital cGvHD was observed in this population-based prospective study. MATERIAL AND METHODS: Women (n = 41) receiving alloHCT in 2005-2010 were examined before and at 3, 6, 9, 12, 18, 24, 30, and 36 months post-transplant...
May 12, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29738424/effects-of-vaginal-estradiol-tablets-and-moisturizer-on-menopause-specific-quality-of-life-and-mood-in-healthy-postmenopausal-women-with-vaginal-symptoms-a-randomized-clinical-trial
#6
Susan J Diem, Katherine A Guthrie, Caroline M Mitchell, Susan D Reed, Joseph C Larson, Kristine E Ensrud, Andrea Z LaCroix
OBJECTIVE: Compare the effects of a vaginal estradiol tablet and a vaginal moisturizer, each to placebo, on menopause-related quality of life and mood in postmenopausal women with moderate-severe vulvovaginal symptoms. METHODS: A total of 302 postmenopausal women enrolled in a 12-week, double-blind, placebo-controlled randomized trial were assigned to vaginal 10 μg estradiol tablet plus placebo gel (n = 102), vaginal moisturizer plus placebo tablet (n = 100), or dual placebo (n = 100)...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29738415/efficacy-of-injecting-platelet-concentrate-combined-with-hyaluronic-acid-for-the-treatment-of-vulvovaginal-atrophy-in-postmenopausal-women-with-history-of-breast-cancer-a-phase-2-pilot-study
#7
Barbara Hersant, Mounia SidAhmed-Mezi, Yazid Belkacemi, Franklin Darmon, Sylvie Bastuji-Garin, Gabrielle Werkoff, Romain Bosc, Jeremy Niddam, Oana Hermeziu, Simone La Padula, Jean Paul Meningaud
OBJECTIVE: Approximately 50% to 70% of breast cancer survivors are affected by one or more symptoms of vulvovaginal atrophy (VVA). For those who cannot take hormone therapy, autologous platelet-rich plasma combined with hyaluronic acid (A-PRP-HA) may provide a new alternative therapy for the treatment of VVA in postmenopausal women with history of breast cancer. METHODS: We enrolled 20 postmenopausal breast cancers survivors with VVA and a score of <15 on the Gloria Bachman Vaginal Health Index (VHI) comprised of five items including: vaginal pH, elasticity, fluid volume (secretions), epithelial integrity, and moisture...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29736603/psoriasin-a-novel-anti-candida-albicans-adhesin
#8
Annelie Brauner, Cathrin Alvendal, Milan Chromek, Konrad H Stopsack, Sophia Ehrström, Jens M Schröder, Nina Bohm-Starke
Candida albicans belongs to the normal microbial flora on epithelial surfaces of humans. However, under certain, still not fully understood conditions, it can become pathogenic and cause a spectrum of diseases, from local infections to life-threatening septicemia. We investigated a panel of antimicrobial proteins and peptides (AMPs), potentially involved in mucosal immunity against this pathogen. Out of six studied AMPs, psoriasin was most up-regulated during a mucosal infection, an acute episode of recurrent Candida vulvovaginitis, although candidacidal activity has not been demonstrated...
May 7, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29734845/the-prevalence-and-determinants-of-genitourinary-syndrome-of-menopause-in-chinese-mid-life-women-a-single-center-study
#9
M Tao, L Geng, Y Zheng, Y Zhou, C Li
OBJECTIVE: This study aimed to explore the prevalence and determinants of genitourinary syndrome of menopause (GSM) in Chinese mid-life women. METHODS: A cross-sectional single-center study was performed among 40-65-year-old women who participated in physical examinations at Shanghai Jiao Tong University Affiliated Sixth People's Hospital from December 2015 to December 2016. The participating women were questioned about their genitourinary symptoms, and the relationships between these symptoms and the women's demographic characteristics were evaluated...
May 8, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29730129/anticandidal-synergistic-activity-of-ocimum-sanctum-and-fluconazole-of-azole-resistance-strains-of-clinical-isolates
#10
K U Zaidi, F Shah, R Parmar, V Thawani
Candida albicans is the most prevalent fungal pathogen in humans. It is the causative agent and most associated with serious fungal infection, accounting for more than 90% of cases. It is a most common cause of deep mycoses and vulvovaginal candidiasis. In the present study we found that methanolic extract of O. sanctum in combination of fluconazole shows higher zone of inhibition and lesser MIC values as compared to methanolic extract of leaves of O. sanctum or fluconazole when used alone. Synergistic antimicrobial activity was found when methanolic extract of leaves of O...
May 2, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29726916/treatment-to-external-labia-and-vaginal-canal-with-co2-laser-for-symptoms-of-vulvovaginal-atrophy-in-postmenopausal-women
#11
Julene B Samuels, Martin A Garcia
Background: Increasingly, women have sought alternatives to traditional options (lubricants, estrogen products, and hormone replacement therapy) for unwelcome vaginal changes of menopause. Objectives: This study evaluated whether a series of three monthly fractional CO2 laser treatments significantly improves and maintains vaginal health indices of elasticity, fluid volume, pH level, epithelial integrity, and moisture. Self-reported symptoms of vaginal atrophy were also measured...
April 13, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29707675/identification-of-candida-species-isolated-from-vulvovaginitis-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#12
Majid Alizadeh, Anna Kolecka, Teun Boekhout, Hossein Zarrinfar, Mohamad A Ghanbari Nahzag, Parisa Badiee, Ali Rezaei-Matehkolaei, Abdolmajid Fata, Somayeh Dolatabadi, Mohammad J Najafzadeh
Background and Purpose: Vulvovaginal candidiasis (VVC) is a common problem in women. The purpose of this study was to identify Candida isolates by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) from women with vulvovaginitis that were referred to Ghaem Hospital, Mashhad, Iran. Materials and Methods: This study was conducted on 65 clinical samples isolated from women that were referred to Ghaem Hospital. All specimens were identified using phenotyping techniques, such as microscopy and culture on Sabouraud dextrose agar and corn meal agar...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29707672/evaluation-of-esterase-and-hemolysin-activities-of-different-candida-species-isolated-from-vulvovaginitis-cases-in-lorestan-province-iran
#13
Maryam Noori, Mohammad Dakhili, Asghar Sepahvand, Nader Davari
Background and Purpose: Annually affecting millions of women, vulvovaginal candidiasis (VVC) is commonly described by signs and symptoms of vulvovaginal inflammation in the presence of  Candida  species. Today, the detection of the virulence factors plays a major role in the understanding of pathogenesis of candidiasis and helps produce new anticandidial drugs to improve its treatment efficiency. Herein, we aimed to evaluate the esterase and hemolysin activities of the vaginal isolates of Candida and their relationship with the presence of VVC...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29701623/histologic-and-clinical-changes-in-vulvovaginal-tissue-after-treatment-with-a-transcutaneous-temperature-controlled-radiofrequency-device
#14
Monique J Vanaman Wilson, Joanna Bolton, Isabela T Jones, Douglas C Wu, Antoanella Calame, Mitchel P Goldman
BACKGROUND: Although transcutaneous temperature-controlled radiofrequency (TTCRF) may effectively treat vulvovaginal laxity (VVL), atrophic vaginitis (AV), orgasmic dysfunction (OD), and stress urinary incontinence (SUI), there is a lack of histopathologic evidence to validate its use. OBJECTIVE: Evaluate clinical and histological changes induced by vulvovaginal TTCRF. MATERIALS AND METHODS: This was a prospective, nonrandomized trial. Ten female subjects with mild-to-moderate VVL, with or without AV, OD, and/or SUI underwent 3 TTCRFs at 4-week intervals...
May 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29699432/vaginal-antiseptics-reduce-the-risk-of-perinatal-infection-with-group-b-streptococci
#15
Jesús Joaquín Hijona, Antonio Luis Carballo, María Soledad Sánchez, Nataliya Dyachkova, Juan Francisco Expósito, José Luis Alcázar
OBJECTIVE: To evaluate the efficacy and safety of dequalinium chloride (DQC; 10 mg vaginal tablets), administered shortly prior to delivery in women with group B streptococcus (GBS) infection. METHODS: This observational, longitudinal, and prospective study involved 201 pregnant women at term, potentially carriers of GBS bacteria, scheduled for induction with oxytocin and with no premature rupture of amniotic membranes. RESULTS: A total of 163 women (81...
April 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29697770/a-therapeutic-vaccine-for-recurrent-vulvovaginal-candidiasis
#16
Arturo Casadevall, Liise-Anne Pirofski
No abstract text is available yet for this article.
April 25, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29697768/a-fungal-immunotherapeutic-vaccine-ndv-3a-for-treatment-of-recurrent-vulvovaginal-candidiasis-a-phase-2-randomized-double-blind-placebo-controlled-trial
#17
John E Edwards, Michael M Schwartz, Clint S Schmidt, Jack D Sobel, Paul Nyirjesy, Florian Schodel, Erica Marchus, Mary Lizakowski, Elizabeth A DeMontigny, Jesse Hoeg, Tuomas Holmberg, M Timothy Cooke, Keila Hoover, Lance Edwards, Mark Jacobs, Steven Sussman, Michael Augenbraun, Michael Drusano, Michael R Yeaman, Ashraf S Ibrahim, Scott G Filler, John P Hennessey
Background: Recurrent vulvovaginal candidiasis (RVVC) is a problematic form of mucosal Candida infection, characterized by repeated episodes per year. Candida albicans is the most common cause of RVVC. Currently, there are no immunotherapeutic treatments for RVVC. Methods: This exploratory randomized, double-blind, placebo-controlled trial evaluated an immunotherapeutic vaccine (NDV-3A) containing a recombinant C. albicans adhesin/invasin protein for prevention of RVVC...
April 25, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29695056/burden-of-serious-fungal-infections-in-argentina
#18
Fernando O Riera, Juan P Caeiro, David W Denning
The number of fungal infections at any given time in Argentina is not known. Here we estimate the burden of serious fungal infections in Argentina for the first time. Specific population statistics were searched from multiple sources, local literature was identified, and estimates made. Some additional data were sourced from the Ministry of Health, the Global Initiative for Asthma (GINA) program, and national haematology and transplant societies. Argentina has a population of 43.8 million, with 25% of this total being children under 15 years...
April 24, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29685081/longitudinal-trajectory-of-vulvovaginal-candidiasis-trichomoniasis-and-bacterial-vaginosis-during-pregnancy-as-well-as-the-impact-on-pregnancy-outcome-a-preliminary-study
#19
Cheng-Yang Hu, Feng-Li Li, Xiao-Guo Hua, Wen-Jiang, Xiu-Jun Zhang
OBJECTIVES: The aims of this study were to describe the course of vulvovaginal candidiasis (VVC), trichomoniasis, and bacterial vaginosis (BV) in pregnancy and to explore the association between these longitudinal changes and pregnancy outcomes. METHODS: A total of 793 pregnant women were enrolled at the first trimester of pregnancy and were followed prospectively twice at the second and third trimester. VVC, trichomoniasis, and BV were evaluated at each trimester of pregnancy...
April 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29681727/time-kill-kinetics-of-rezafungin-cd101-in-vagina-simulative-medium-for-fluconazole-susceptible-and-fluconazole-resistant-candida-albicans-and-non-albicans-candida-species
#20
Jeffrey B Locke, Amanda L Almaguer, Joanna L Donatelli, Ken F Bartizal
Background: While echinocandins demonstrate excellent efficacy against Candida species in disseminated infections and demonstrate potent minimal inhibitory concentration (MIC) values under standard susceptibility testing conditions, investigation under conditions relevant to the vaginal environment was needed. We assessed the antifungal activity and time-kill kinetics of the novel echinocandin rezafungin (formerly CD101) under such conditions, against Candida species relevant to vulvovaginal candidiasis (VVC)...
2018: Infectious Diseases in Obstetrics and Gynecology
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