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https://www.readbyqxmd.com/read/29906653/estimation-of-the-ear-canal-displacement-field-due-to-in-ear-device-insertion-using-a-registration-method-on-a-human-like-artificial-ear
#1
S Benacchio, O Doutres, A Le Troter, A Varoquaux, E Wagnac, V Callot, F Sgard
Passive and active in-ear devices (IED) occluding the ear canal are commonly used to (i) protect people from high noise levels (earplugs), (ii) assist people suffering from hearing impairment (hearing aids) or (iii) help people in listening from their sound systems (earbuds). However, the usability and/or efficiency of IEDs can be greatly affected by several discomfort components (physical, acoustical and functional). The mechanical pressure exerted by the IED onto the ear canal walls is greatly suspected to affect the aforementioned comfort components...
June 2, 2018: Hearing Research
https://www.readbyqxmd.com/read/29906651/quantifying-facial-expression-signal-and-intensity-use-during-development
#2
Helen Rodger, Junpeng Lao, Roberto Caldara
Behavioral studies investigating facial expression recognition during development have applied various methods to establish by which age emotional expressions can be recognized. Most commonly, these methods employ static images of expressions at their highest intensity (apex) or morphed expressions of different intensities, but they have not previously been compared. Our aim was to (a) quantify the intensity and signal use for recognition of six emotional expressions from early childhood to adulthood and (b) compare both measures and assess their functional relationship to better understand the use of different measures across development...
June 12, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29906635/learning-of-goal-relevant-and-irrelevant-complex-visual-sequences-in-human-v1
#3
Clive R Rosenthal, Indira Mallik, Cesar Caballero-Gaudes, Martin I Sereno, David Soto
Learning and memory are supported by a network involving the medial temporal lobe and linked neocortical regions. Emerging evidence indicates that primary visual cortex (i.e., V1) may contribute to recognition memory, but this has been tested only with a single visuospatial sequence as the target memorandum. The present study used functional magnetic resonance imaging to investigate whether human V1 can support the learning of multiple, concurrent, and complex visual sequences involving discontinous (second-order) associations...
June 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29906634/whole-head-quantitative-susceptibility-mapping-using-a-least-norm-direct-dipole-inversion-method
#4
Hongfu Sun, Yuhan Ma, M Ethan MacDonald, G Bruce Pike
A new dipole field inversion method for whole head quantitative susceptibility mapping (QSM) is proposed. Instead of performing background field removal and local field inversion sequentially, the proposed method performs dipole field inversion directly on the total field map in a single step. To aid this under-determined and ill-posed inversion process and obtain robust QSM images, Tikhonov regularization is implemented to seek the local susceptibility solution with the least-norm (LN) using the L-curve criterion...
June 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29906552/interleukin-33-protects-ischemic-brain-injury-by-regulating-specific-microglial-activities
#5
Qianping Luo, Yong Fan, Lili Lin, Jingjing Wei, Zuanfang Li, Yongkun Li, Susumu Nakae, Wei Lin, Qi Chen
Interleukin-33 (IL-33), a novel member of the IL-1 family, expressed in many tissue and cell types, and is involved in inflammation and immune functions. Previous studies suggest that IL-33 may play a role in ischemic stroke. We tried to investigate the role of IL-33 in cerebral ischemia-reperfusion-induced injury and its underlying mechanism. Our data indicated that IL-33 deficiency exacerbated the neurological dysfunction caused by cerebral ischemia-reperfusion injury in mice and led to the formation of larger cerebral infarct volume as shown by 2,3,5-triphenyltetrazolium chloride (TTC) staining and magnetic resonance imaging...
June 12, 2018: Neuroscience
https://www.readbyqxmd.com/read/29906489/taste-at-first-person-sight-visual-perspective-modulates-brain-activity-implicitly-associated-with-viewing-unhealthy-but-not-healthy-foods
#6
Frédéric Basso, Olivia Petit, Sophie Le Bellu, Saadi Lahlou, Aïda Cancel, Jean-Luc Anton
Every day, people are exposed to images of appetizing foods that can lead to high-calorie intake and contribute to overweight and obesity. Research has documented that manipulating the visual perspective from which eating is viewed helps resist temptation by altering the appraisal of unhealthy foods. However, the neural basis of this effect has not yet been examined using neuroimaging methods. Moreover, it is not known whether the benefits of this strategy can be observed when people, especially overweight, are not explicitly asked to imagine themselves eating...
June 12, 2018: Appetite
https://www.readbyqxmd.com/read/29906397/synthesis-of-single-walled-carbon-nanotubes-coated-with-thiol-reactive-gel-via-emulsion-polymerization
#7
Yukiko Nagai, Yusuke Tsutsumi, Naotoshi Nakashima, Tsuyohiko Fujigaya
Single-walled carbon nanotubes (SWNTs) have unique near-infrared absorption and photoemission properties that are attractive for in vivo biological applications such as photothermal cancer treatment and bioimaging. Therefore, a smart functionalization strategy for SWNTs to create biocompatible surfaces and introduce various ligands to target active cancer cells without losing the unique optical properties of the SWNTs is strongly desired. This paper reports the de-sign and synthesis of a SWNT/gel hybrid containing maleimide groups, which react with various thiol compounds through Michael addition reactions...
June 15, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29906102/unraveling-the-detailed-mechanism-of-excited-state-proton-transfer
#8
Panwang Zhou, Keli Han
As one of the most fundamental processes, excited-state proton transfer (ESPT) plays a major role in both chemical and biological systems. In the past several decades, experimental and theoretical studies on ESPT systems have attracted considerable attention because of their tremendous potential in fluorescent probes, biological imaging, white-light-emitting materials, and organic optoelectronic materials. ESPT is related to fluorescence properties and usually occurs on an ultrafast time scale at or below 100 fs...
June 15, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29905743/self-calibration-of-lensless-holographic-endoscope-using-programmable-guide-stars
#9
Robert Kuschmierz, Elias Scharf, Nektarios Koukourakis, Jürgen W Czarske
Coherent fiber bundle (CFB)-based endoscopes enable optical keyhole access in applications such as biophotonics. In conjunction with objective lenses, CFBs allow imaging of intensity patterns. In contrast, digital optical phase conjugation enables lensless holographic endoscopes for the generation of pixelation-free arbitrary light patterns. For real-world applications, however, this requires a non-invasive in situ calibration of the complex optical transfer function of the CFB with only single-sided access...
June 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29905737/quantitative-differential-phase-contrast-imaging-at-high-resolution-with-radially-asymmetric-illumination
#10
Yu-Zi Lin, Kuang-Yuh Huang, Yuan Luo
Half-circle illumination-based differential phase contrast (DPC) microscopy has been utilized to recover phase images through a pair of images along multiple axes. Recently, the half-circle based DPC using 12-axis measurements significantly provides a circularly symmetric phase transfer function to improve accuracy for more stable phase recovery. Instead of using half-circle-based DPC, we propose a new scheme of DPC under radially asymmetric illumination to achieve circularly symmetric phase transfer function and enhance the accuracy of phase recovery in a more stable and efficient fashion...
June 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29905656/pain-processing-in-the-human-brainstem-and-spinal-cord-before-during-and-after-the-application-of-noxious-heat-stimuli
#11
P W Stroman, G Ioachim, J M Powers, R Staud, C Pukall
Descending regulation of spinal cord responses to nociceptive signaling has a strong influence on pain perception. Prior studies using functional magnetic resonance imaging (fMRI) have indicated that in addition to reactive responses to nociceptive signals there is a continuous component to regulation, and that it may vary with differences in pain sensitivity. We hypothesize that this continuous regulation component occurs routinely in fMRI studies prior to noxious stimulation, as well as during, and following stimulation...
June 12, 2018: Pain
https://www.readbyqxmd.com/read/29905626/ulnar-nerve-injury-in-pediatric-midshaft-forearm-fractures-a-case-series
#12
Andrew E Federer, Joshua S Murphy, James H Calandruccio, Dennis P Devito, Scott H Kozin, Greg S Slappey, Gary M Lourie
OBJECTIVES: To describe a midshaft forearm fracture pattern that places the ulnar nerve at risk in the pediatric population and provide seven clinical case examples describing the injury pattern and treatment methods. DESIGN: Retrospective observational case series, review of literature, cadaver dissection, and treatment recommendations. SETTING: Multi-institutional, Southeast United States PATIENTS:: Seven pediatric patients (5 male, 2 female) with mean age of 8...
June 4, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29905521/contrast-enhanced-ultrasound-to-visualize-hemodynamic-changes-after-rodent-spinal-cord-injury
#13
Zin Z Khaing, Lindsay N Cates, Dane M DeWees, Alexander Hannah, Pierre Mourad, Matthew Bruce, Christoph P Hofstetter
OBJECTIVE Traumatic spinal cord injury (tSCI) causes an almost complete loss of blood flow at the site of injury (primary injury) as well as significant hypoperfusion in the penumbra of the injury. Hypoperfusion in the penumbra progresses after injury to the spinal cord and is likely to be a major contributor to progressive cell death of spinal cord tissue that was initially viable (secondary injury). Neuroprotective treatment strategies seek to limit secondary injury. Clinical monitoring of the temporal and spatial patterns of blood flow within the contused spinal cord is currently not feasible...
June 15, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29905462/the-human-biomolecular-corona-of-liposomal-doxorubicin-the-overlooked-factor-in-anticancer-drug-delivery
#14
Giulio Caracciolo, Sara Palchetti, Luca Digiacomo, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Heinz Amenitsch, Paolo Maria Tentori, Valentina Palmieri, Massimiliano Papi, Francesco Cardarelli, Daniela Pozzi, Aldo Laganà
More than twenty years after its approval by the Food and Drug Administration (FDA) liposomal doxorubicin (DOX) is still the drug of choice for the treatment of breast cancer and other conditions such as ovarian cancer and multiple myeloma. Yet, despite the efforts, liposomal DOX did not satisfy expectations at the clinical level. When liposomal drugs enter a physiological environment, their surface gets coated by a dynamic biomolecular corona (BC). The BC changes liposome's synthetic identity, providing it with a new one, referred to as 'biological identity' (size, aggregation state, and BC composition)...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29905117/melanopsin-expression-in-the-cornea
#15
Anton Delwig, Shawnta Y Chaney, Andrea S Bertke, Jan Verweij, Susana Quirce, Delaine D Larsen, Cindy Yang, Ethan Buhr, Russell VAN Gelder, Juana Gallar, Todd Margolis, David R Copenhagen
A unique class of intrinsically photosensitive retinal ganglion cells in mammalian retinae has been recently discovered and characterized. These neurons can generate visual signals in the absence of inputs from rods and cones, the conventional photoreceptors in the visual system. These light sensitive ganglion cells (mRGCs) express the non-rod, non-cone photopigment melanopsin and play well documented roles in modulating pupil responses to light, photoentrainment of circadian rhythms, mood, sleep and other adaptive light functions...
January 2018: Visual Neuroscience
https://www.readbyqxmd.com/read/29905037/gpu-based-deep-convolutional-neural-network-for-tomographic-phase-microscopy-with-%C3%A2-1-fitting-and-regularization
#16
Hui Qiao, Jiamin Wu, Xiaoxu Li, Morteza H Shoreh, Jingtao Fan, Qionghai Dai
Tomographic phase microscopy (TPM) is a unique imaging modality to measure the three-dimensional refractive index distribution of transparent and semitransparent samples. However, the requirement of the dense sampling in a large range of incident angles restricts its temporal resolution and prevents its application in dynamic scenes. Here, we propose a graphics processing unit-based implementation of a deep convolutional neural network to improve the performance of phase tomography, especially with much fewer incident angles...
June 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29904951/a-magnifying-glass-for-virtual-imaging-of-subwavelength-resolution-by-transformation-optics
#17
Fei Sun, Shuwei Guo, Yichao Liu, Sailing He
Traditional magnifying glasses can give magnified virtual images with diffraction-limited resolution, that is, detailed information is lost. Here, a novel magnifying glass by transformation optics, referred to as a "superresolution magnifying glass" (SMG) is designed, which can produce magnified virtual images with a predetermined magnification factor and resolve subwavelength details (i.e., light sources with subwavelength distances can be resolved). Based on theoretical calculations and reductions, a metallic plate structure to produce the reduced SMG in microwave frequencies, which gives good performance verified by both numerical simulations and experimental results, is proposed and realized...
June 14, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29904817/optimization-of-temporal-sampling-for-18-f-choline-uptake-quantification-in-prostate-cancer-assessment
#18
Xavier Palard-Novello, Anne-Lise Blin, Florence Le Jeune, Etienne Garin, Pierre-Yves Salaün, Anne Devillers, Giulio Gambarota, Solène Querellou, Patrick Bourguet, Hervé Saint-Jalmes
BACKGROUND: Suboptimal temporal sampling of time-activity curves (TAC) from dynamic 18 F-fluoromethylcholine (FCH) PET images may introduce bias in quantification of FCH uptake in prostate cancer assessment. We sought to define an optimal temporal sampling protocol for dynamic FCH PET imaging. Seven different time samplings were tested: 5 × 60″, 10 × 30″, 15 × 15″-1 × 75″, 6 × 10″-8 × 30″, 12 × 5″-8 × 30″; 10 × 5″-4 × 10″-3 × 20″-5 × 30″, and 8 × 3″-8 × 12″-6 × 30″...
June 15, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29904787/estimating-mechanical-properties-of-cloth-from-videos-using-dense-motion-trajectories-human-psychophysics-and-machine-learning
#19
Wenyan Bi, Peiran Jin, Hendrikje Nienborg, Bei Xiao
Humans can visually estimate the mechanical properties of deformable objects (e.g., cloth stiffness). While much of the recent work on material perception has focused on static image cues (e.g., textures and shape), little is known about whether humans can integrate information over time to make a judgment. Here we investigated the effect of spatiotemporal information across multiple frames (multiframe motion) on estimating the bending stiffness of cloth. Using high-fidelity cloth animations, we first examined how the perceived bending stiffness changed as a function of the physical bending stiffness defined in the simulation model...
May 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29904764/recombinant-fully-human-antibody-decorated-highly-stable-far-red-aiedots-for-in-vivo-her-2-receptor-targeted-imaging
#20
Yayun Wu, Zhizhen Chen, Pengfei Zhang, Lihua Zhou, Tao Jiang, Huajie Chen, Ping Gong, Dimiter S Dimitrov, Lintao Cai, Qi Zhao
We developed highly bright and stable far-red emissive AIEdots by using a new kind of click-functional PEG grafted amphiphilic polymer to coat hydrophobic AIE-active polymers (PDFDP). Furthermore, an anti-HER2 recombinant fully human antibody was produced and conjugated on the AIEdots via metal-free click chemistry to fabricate in vivo tumor-targeting nanoprobes.
June 15, 2018: Chemical Communications: Chem Comm
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