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https://www.readbyqxmd.com/read/29679870/application-of-enteromorpha-polysaccharides-as-coagulant-aid-in-the-simultaneous-removal-of-cuo-nanoparticles-and-cu-2-effect-of-humic-acid-concentration
#1
Yuanxia Luo, Baoyu Gao, Qinyan Yue, Ruihua Li
Humic acid (HA) influences the aggregation and stability of nanoparticles (NPs), which determine the removal performance of NPs in coagulation. Consequently, in this study, the impact of HA concentration on the simultaneous removal of CuO NPs, Cu2+ , and natural organic matter (NOM) was investigated. Enteromorpha polysaccharides (Ep), as the novel recycling coagulant aid, were integrated with polyaluminum chloride (PAC) to treat composite contaminants in this coagulation process. Removal performance, floc properties, zeta potential, scanning electron microscope (SEM) images, and Fourier Transform Infrared Spectra (FT-IR) were measured and analyzed...
March 26, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679850/non-suicidal-self-injury-in-patients-with-eating-disorders-prevalence-forms-functions-and-body-image-correlates
#2
Sandra Pérez, Jos H Marco, Montse Cañabate
INTRODUCTION: More than one third of patients with eating disorders report NSSI. Moreover, negative attitudes and feelings toward the body, body dissatisfaction, and body image disturbances have been linked to NSSI in community and clinical samples. However, there is a lack of studies exploring NSSI frequency and functions and the specific relationship between multidimensional body image dimensions and NSSI in eating disorder patients. OBJECTIVES: First, we explored the frequency, types, and functions of NSSI in a sample of 226 Spanish female participants with eating disorders (ED)...
April 12, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29679735/age-dependent-effects-of-brain-stimulation-on-network-centrality
#3
Daria Antonenko, Till Nierhaus, Marcus Meinzer, Kristin Prehn, Axel Thielscher, Bernd Ittermann, Agnes Flöel
Functional magnetic resonance imaging (fMRI) studies have suggested that advanced age may mediate the effects of transcranial direct current stimulation (tDCS) on brain function. However, studies directly comparing neural tDCS effects between young and older adults are scarce and limited to task-related imaging paradigms. Resting-state (rs-) fMRI, that is independent of age-related differences in performance, is well suited to investigate age-associated differential neural tDCS effects. Three "online" tDCS conditions (anodal, cathodal, sham) were compared in a cross-over, within-subject design, in 30 young and 30 older adults...
April 18, 2018: NeuroImage
https://www.readbyqxmd.com/read/29679729/a-longitudinal-study-of-disc-height-narrowing-and-facet-joint-osteoarthritis-at-the-thoracic-and-lumbar-spine-evaluated-by-computed-tomography-the-framingham-study
#4
Mohamed Jarraya, Ali Guermazi, Amanda L Lorbergs, Elana Brochin, Douglas P Kiel, Mary L Bouxsein, L Adrienne Cupples, Elizabeth J Samelson
BACKGROUND CONTEXT: Prevalence and progression of disc height narrowing (DHN) and facet joint osteoarthritis (FJOA) in the thoracic and lumbar regions in non-clinical populations are not well-established. PURPOSE: Use computed tomography (CT) images to determine prevalence and progression of DHN and FJOA according to age, sex, and spinal region. STUDY DESIGN: Six-year longitudinal study SAMPLE: 1,196 members of the Framingham Study (mean baseline age 61 ±9 years) OUTCOME MEASURES: We compared prevalence and progression (new or worsening) of moderate-to-severe DHN and FJOA by age, sex, and spinal region...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679616/early-detection-of-diabetic-retinopathy
#5
REVIEW
Hamid Safi, Sare Safi, Ali Hafezi-Moghadam, Hamid Ahmadieh
Diabetic retinopathy (DR) is a primary cause of visual impairment worldwide. Diabetes mellitus may be associated with ophthalmoscopically nonvisible neurovascular damage that progresses before the first clinical signs of DR appear. Reduction of the inner neuroretinal layer thickness on macular optical coherence tomography (OCT), reduced contrast sensitivity primarily at low spatial frequencies, abnormal results in color vision and microperimetry tests, and a prolonged implicit time recorded by multifocal electroretinography have been proposed for detection of early functional and nonvisible structural neuroretinal changes...
April 18, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29679574/evidence-of-demyelination-in-mild-cognitive-impairment-and-dementia-using-a-direct-and-specific-magnetic-resonance-imaging-measure-of-myelin-content
#6
Mustapha Bouhrara, David A Reiter, Christopher M Bergeron, Linda M Zukley, Luigi Ferrucci, Susan M Resnick, Richard G Spencer
INTRODUCTION: We investigated brain demyelination in aging, mild cognitive impairment (MCI), and dementia using magnetic resonance imaging of myelin. METHODS: Brains of young and old controls and old subjects with MCI, Alzheimer's disease, or vascular dementia were scanned using our recently developed myelin water fraction (MWF) mapping technique, which provides greatly improved accuracy over previous comparable methods. Maps of MWF, a direct and specific myelin measure, and relaxation times and magnetization transfer ratio, indirect and nonspecific measures, were constructed...
April 18, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29679528/intravoxel-incoherent-motion-diffusion-weighted-imaging-of-primary-rectal-carcinoma-correlation-with-histopathology
#7
Baolan Lu, Xinyue Yang, Xiaojuan Xiao, Yan Chen, Xu Yan, Shenping Yu
BACKGROUND Comprehensive and precise assessment of rectal carcinoma is crucial before surgery to plan an individual treatment strategy. New functional techniques, such as intravoxel incoherent motion (IVIM), have emerged and could lead to more detailed information. The aim of this study was to evaluate the difference between the rectal tumor parenchyma and normal wall by IVIM and to explore the correlations of IVIM parameters and histopathology. MATERIAL AND METHODS We prospectively enrolled 128 patients with pathologically proven rectal non-mucinous carcinoma with differentiation degree and 16 patients with mucinous carcinoma...
April 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29679319/multifunctional-self-assembling-peptide-based-nanostructures-for-targeted-intracellular-delivery-design-physicochemical-characterization-and-biological-assessment
#8
Yejiao Shi, Ran Lin, Honggang Cui, Helena S Azevedo
Peptide amphiphiles (PAs), consisting of a hydrophobic alkyl chain covalently bound to a hydrophilic peptide sequence, possess a versatile molecular design due to their combined self-assembling features of amphiphile surfactants and biological functionalities of peptides. Through rational design, PAs can self-assemble into a variety of nanostructures with controlled shape, size, and biological functionality to deliver therapeutic and imaging agents to target cells. Here, we describe principles to design multifunctional PAs for self-assembly into micellar nanostructures and targeted intracellular delivery...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29679138/sexual-quality-of-life-body-image-distress-and-psychosocial-outcomes-in-colorectal-cancer-a-longitudinal-study
#9
Jennifer Barsky Reese, Elizabeth Handorf, Jennifer A Haythornthwaite
PURPOSE: The objectives were to assess changes in sexual QOL and body image distress over time and to examine longitudinal associations between sexual QOL and body image variables with psychosocial outcomes in a sample of colorectal cancer patients. METHODS: Participants (N = 141) completed a mail-based survey assessing sexual QOL [sexual distress (ISS), treatment impact on sexual function (SFQ), sexual function (FSFI; IIEF)], body image distress (BIS), and psychosocial outcomes [relationship quality (DAS-4), depressive symptoms (CESD-SF), and health-related QOL (HRQOL; FACT-C)]; 88 patients completed 6-month follow-up surveys (62%)...
April 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29679060/mechanically-interlocked-functionalization-of-monoclonal-antibodies
#10
Krzysztof P Bzymek, James W Puckett, Cindy Zer, Jun Xie, Yuelong Ma, Jeremy D King, Leah H Goodstein, Kendra N Avery, David Colcher, Gagandeep Singh, David A Horne, John C Williams
Because monoclonal antibodies (mAbs) have exceptional specificity and favorable pharmacology, substantial efforts have been made to functionalize them, either with potent cytotoxins, biologics, radionuclides, or fluorescent groups for therapeutic benefit and/or use as theranostic agents. To exploit our recently discovered meditope-Fab interaction as an alternative means to efficiently functionalize mAbs, we used insights from the structure to enhance the affinity and lifetime of the interaction by four orders of magnitude...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29678906/rnai-screening-identifies-a-mechanosensitive-rock-jak2-stat3-network-central-to-myofibroblast-activation
#11
Raymond S Oh, Andrew J Haak, Karry M J Smith, Giovanni Ligresti, Kyoung Moo Choi, Tiao Xie, Shaohua Wang, Paula R Walters, Michael A Thompson, Michelle R Freeman, Logan J Manlove, Vivian M Chu, Carol Feghali-Bostwick, Anja C Roden, Jürgen Schymeinsky, Christina M Pabelick, Y S Prakash, Robert Vassallo, Daniel J Tschumperlin
Myofibroblasts play key roles in wound healing and pathologic fibrosis. Here we undertook an RNAi screen to characterize myofibroblast regulatory genes, using a high-content imaging approach to quantify alpha-smooth muscle actin stress fibers in cultured human fibroblasts. Screen hits were validated on physiological compliance hydrogels, and selected hits tested in primary fibroblasts from patients with idiopathic pulmonary fibrosis. Our RNAi screen led to the identification of STAT3 as an essential mediator of myofibroblast activation and function...
April 20, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29678785/integrin-%C3%AE-v%C3%AE-6-structure-function-and-role-in-health-and-disease
#12
REVIEW
Leeni Koivisto, Jiarui Bi, Lari Häkkinen, Hannu Larjava
Integrins are cell surface receptors that traditionally mediate cell-to-extracellular matrix and cell-to-cell adhesion. They can, however, also bind a large repertoire of other molecules. Integrin αvβ6 is exclusively expressed in epithelial cells where it can, for example, serve as a fibronectin receptor. However, its hallmark function is to activate transforming growth factor-β1 (TGF-β1) to modulate innate immune surveillance in lungs and skin and along the gastrointestinal tract, and to maintain epithelial stem cell quiescence...
April 17, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29678780/left-ventricular-regional-remodeling-and-lead-position-during-cardiac-resynchronization-therapy
#13
Mads B Kronborg, Anders Sommer, Daniel B Fyenbo, Bjarne L Norgaard, Christian Gerdes, Jesper Moller Jensen, Henrik Kjærulf Jensen, Jens Kristensen, Jens C Nielsen
BACKGROUND: Cardiac resynchronization therapy (CRT) induces segmental left ventricular (LV) remodeling. LV lead position (LV-LP) impacts response to CRT and remodeling. OBJECTIVE: We aimed to assess segmental remodeling concordant, adjacent, and remote to LV-LP using cardiac computed tomography (CT). METHODS: We included patients from the ImagingCRT (Empiric versus Imaging-Guided Left Ventricular Lead Placement in Cardiac Resynchronization Therapy) Trial...
April 17, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29678757/ultra-coarse-single-glance-human-face-detection-in-a-dynamic-visual-stream
#14
Genevieve L Quek, Joan Liu-Shuang, Valérie Goffaux, Bruno Rossion
Effective human interaction depends on our ability to rapidly detect faces in dynamic visual environments. Here we asked how basic units of visual information (spatial frequencies, or SF) contribute to this fundamental brain function. Human observers viewed initially blurry, unrecognizable natural object images presented at a fast 12 Hz rate and parametrically increasing in SF content over the course of 1 min. By inserting highly variable natural face images as every 8th stimulus we captured an objective neural index of face detection in participants' electroencephalogram (EEG) at exactly 1...
April 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29678704/clinical-parameters-to-distinguish-silent-corticotroph-adenomas-from-other-nonfunctioning-pituitary-adenomas
#15
Daham Kim, Cheol Ryong Ku, Se Hee Park, Ju Hyung Moon, Eui Hyun Kim, Sun Ho Kim, Eun Jig Lee
BACKGROUND: It is difficult to distinguish silent corticotroph adenomas (SCAs) from other nonfunctioning pituitary adenomas (NFPAs) preoperatively. This study aimed to determine the preoperative clinical parameters associated with SCAs. METHODS: This was a retrospective single-center study of patients who underwent surgery for NFPAs during 2011-2016 in our tertiary hospital and who had preoperative combined pituitary function test (CPFT) and immunohistochemical staining results available...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678679/formal-thought-disorders-from-phenomenology-to-neurobiology
#16
REVIEW
Tilo Kircher, Henrike Bröhl, Felicitas Meier, Jennifer Engelen
Formal thought disorder (FTD) is present in most psychiatric disorders and in some healthy individuals. In this Review, we present a comprehensive, integrative, and multilevel account of what is known about FTD, covering genetic, cellular, and neurotransmitter effects, environmental influences, experimental psychology and neuropsychology, brain imaging, phenomenology, linguistics, and treatment. FTD is a dimensional, phenomenologically defined construct, which can be clinically subdivided into positive versus negative and objective versus subjective symptom clusters...
April 17, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29678630/characterization-and-simulation-of-noise-in-pet-images-reconstructed-with-osem-development-of-a-method-for-the-generation-of-synthetic-images
#17
P Castro, C Huerga, P Chamorro, J Garayoa, M Roch, L Pérez
INTRODUCTION: The goals of the study are to characterize imaging properties in 2D PET images reconstructed with the iterative algorithm ordered-subset expectation maximization (OSEM) and to propose a new method for the generation of synthetic images. MATERIAL AND METHODS: The noise is analyzed in terms of its magnitude, spatial correlation, and spectral distribution through standard deviation, autocorrelation function, and noise power spectrum (NPS), respectively...
April 17, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29678380/performance-of-a-computer-aided-digital-dermoscopic-image-analyzer-for-melanoma-detection-in-1-076-pigmented-skin-lesion-biopsies
#18
Francis Del Rosario, Jessica M Farahi, Jesse Drendel, Talayesa Buntinx-Krieg, Joseph Caravaglio, Renee Domozych, Stephanie Chapman, Taylor Braunberger, Robert P Dellavalle, David A Norris, Ramin Fathi, Theodore Alkousakis
BACKGROUND: Digital dermoscopic image analysis of pigmented skin lesions (PSLs) has become increasingly popular, despite its unclear clinical utility. Unbiased, high-powered studies investigating the efficacy of commercially available systems are limited. OBJECTIVE: To investigate the diagnostic performance of the FotoFinder Mole-Analyzer in assessing PSLs for cutaneous melanoma. METHODS: In this 15-year retrospective study, the histopathologies of 1076 biopsied PSLs among a total of 2500 imaged PSLs were collected...
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29678278/periventricular-small-cystic-lesions-in-a-patient-with-coffin-lowry-syndrome-who-exhibited-a-novel-mutation-in-the-rps6ka3-gene
#19
Yohane Miyata, Ken Saida, Satoko Kumada, Noriko Miyake, Hideaki Mashimo, Yuya Nishida, Ikuko Shirai, Eiji Kurihara, Yasuhiro Nakata, Naomichi Matsumoto
BACKGROUND: Coffin-Lowry syndrome is a rare X-linked disease, caused by loss-of-function mutations in the RPS6KA3 gene. Patients exhibit severe intellectual disability with characteristic dysmorphism. As there are no specific laboratory findings to support the diagnosis of Coffin-Lowry syndrome, it may be difficult to diagnose-especially in young children, where the characteristic craniofacial features are less discernible. CASE: Here we report on a 2-year-old boy with Coffin-Lowry syndrome with a novel missense mutation in the RPS6KA3 gene...
April 17, 2018: Brain & Development
https://www.readbyqxmd.com/read/29678195/does-sensorimotor-upper-limb-therapy-post-stroke-alter-behavior-and-brain-connectivity-differently-compared-to-motor-therapy-protocol-of-a-phase-ii-randomized-controlled-trial
#20
Nele De Bruyn, Bea Essers, Liselot Thijs, Annick Van Gils, Lisa Tedesco Triccas, Sarah Meyer, Kaat Alaerts, Geert Verheyden
BACKGROUND: The role of somatosensory feedback in motor performance has been warranted in the literature. Although sensorimotor deficits are common after stroke, current rehabilitation approaches primarily focus on restoring upper limb motor ability. Evidence for integrative sensorimotor rehabilitation approaches is scarce, as is knowledge about neural correlates of somatosensory impairments after stroke and the effect of rehabilitation on brain connectivity level. Therefore, we aim to investigate changes in sensorimotor function and brain connectivity following a sensorimotor therapy program compared to an attention-matched motor therapy program for the upper limb after stroke...
April 20, 2018: Trials
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