keyword
MENU ▼
Read by QxMD icon Read
search

k.t/v

keyword
https://www.readbyqxmd.com/read/29454264/development-and-validation-of-uplc-ms-ms-assay-for-quantification-of-cladrin-absolute-bioavailability-and-dose-proportionality-study-in-rats
#1
Mamunur Rashid, Sandeep K Singh, Mohd Yaseen Malik, Sadaf Jahan, Swati Chaturvedi, Isha Taneja, Kanumuri Sivarama Raju, Zaiba Naseem, J R Gayen, Muhammad Wahajuddin
Cladrin, an isoflavone is a major bioactive constituent found in stem bark of Butea monosperma with remarkable osteogenic activity. A speedy and sensitive UPLC coupled tandem mass spectrometry (UPLC-MS/MS) method was developed, validated and successfully applied to bioavailability, blood partitioning, plasma protein binding, intravenous and multiple-dose oral pharmacokinetics of cladrin in rats. Separation was done on C18 column (5.0 μm, 4.6 × 50 mm) using mobile phase containing acetonitrile and 0.10% formic acid in the ratio of 65:35 (v/v) with 0...
January 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29453344/giant-electrocaloric-and-energy-storage-performance-of-k-0-5-na-0-5-nbo-3-1-x-lisbo-3-x-nanocrystalline-ceramics
#2
Raju Kumar, Satyendra Singh
Electrocaloric (EC) refrigeration, an EC effect based technology has been accepted as an auspicious way in the development of next generation refrigeration due to high efficiency and compact size. Here, we report the results of our experimental investigations on electrocaloric response and electrical energy storage properties in lead-free nanocrystalline (1 - x)K 0.5 Na 0.5 NbO 3 -xLiSbO 3 (KNN-xLS) ceramics in the range of 0.015 ≤ x ≤ 0.06 by the indirect EC measurements. Doping of LiSbO 3 has lowered both the transitions (T C and T O-T ) of KNN to the room temperature side effectively...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453220/identification-of-novel-fusion-transcripts-in-multiple-myeloma
#3
Mingxuan Lin, Peak Ling Lee, Lily Chiu, Constance Chua, Kenneth H K Ban, Adeline H F Lin, Zit Liang Chan, Tae-Hoon Chung, Benedict Yan, Wee-Joo Chng
AIMS: Multiple myeloma (MM) is a heterogeneous disease characterised by genetically complex abnormalities. The classical mutational spectrum includes recurrent chromosomal aberrations and gene-level mutations. Recurrent translocations involving the IGH gene such as t(11;14), t(4;14) and t(14;16) are well known. However, the presence of complex genetic abnormalities raises the possibility that fusions other than the recurrent IGH translocations exist. We therefore employed a targeted RNA-sequencing panel to identify novel putative fusions in a local cohort of MM...
February 16, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29453107/body-fluid-identification-using-a-targeted-mrna-massively-parallel-sequencing-approach-results-of-a-euroforgen-ednap-collaborative-exercise
#4
S Ingold, G Dørum, E Hanson, A Berti, W Branicki, P Brito, P Elsmore, K B Gettings, F Giangasparo, T E Gross, S Hansen, E N Hanssen, M-L Kampmann, M Kayser, F-X Laurent, N Morling, A Mosquera-Miguel, W Parson, C Phillips, M J Porto, E Pośpiech, A D Roeder, P M Schneider, K Schulze Johann, C R Steffen, D Syndercombe-Court, M Trautmann, M van den Berge, K J van der Gaag, J Vannier, V Verdoliva, A Vidaki, C Xavier, J Ballantyne, C Haas
In a previous study we presented an assay for targeted mRNA sequencing for the identification of human body fluids, optimised for the Illumina MiSeq/FGx MPS platform. This assay, together with an additional in-house designed assay for the Ion Torrent PGM/S5 platform, was the basis for a collaborative exercise within 17 EUROFORGEN and EDNAP laboratories, in order to test the efficacy of targeted mRNA sequencing to identify body fluids. The task was to analyse the supplied dried body fluid stains and, optionally, participants' own bona fide or mock casework samples of human origin, according to specified protocols...
January 31, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29453094/a-multidisciplinary-study-of-3-%C3%AE-d-glucopyranosyl-5-substituted-1-2-4-triazole-derivatives-as-glycogen-phosphorylase-inhibitors-computation-synthesis-crystallography-and-kinetics-reveal-new-potent-inhibitors
#5
Sándor Kun, Jaida Begum, Efthimios Kyriakis, Evgenia C V Stamati, Thomas A Barkas, Eszter Szennyes, Éva Bokor, Katalin E Szabó, George A Stravodimos, Ádám Sipos, Tibor Docsa, Pál Gergely, Colin Moffatt, Myrto S Patraskaki, Maria C Kokolaki, Alkistis Gkerdi, Vassiliki T Skamnaki, Demetres D Leonidas, László Somsák, Joseph M Hayes
3-(β-d-Glucopyranosyl)-5-substituted-1,2,4-triazoles have been revealed as an effective scaffold for the development of potent glycogen phosphorylase (GP) inhibitors but with the potency very sensitive to the nature of the alkyl/aryl 5-substituent (Kun et al., Eur. J. Med. Chem. 2014, 76, 567). For a training set of these ligands, quantum mechanics-polarized ligand docking (QM-PLD) demonstrated good potential to identify larger differences in potencies (predictive index PI = 0.82) and potent inhibitors with K i 's < 10 μM (AU-ROC = 0...
February 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29452960/traditionally-practiced-medicinal-plant-extracts-inhibit-the-ergosterol-biosynthesis-of-clinically-isolated-dermatophytic-pathogens
#6
M Chellappandian, M Saravanan, P Pandikumar, P Harikrishnan, K Thirugnanasambantham, S Subramanian, V I Hairul-Islam, S Ignacimuthu
OBJECTIVE: Dermatophytes are resistant to some available antibiotics. Development of new plant drugs to control drug resistant microbes is urgently needed. This study evaluates the antidermatophytic potential of 18 selected medicinal plants used by traditional healers in Theni and Virudhunagar Districts of Tamil Nadu, India. MATERIALS AND METHODS: Selected plant parts were collected, shade dried and powdered. Plant powders were extracted with ethanol and their antifungal potency was investigated against and clinical dermatophytes...
February 13, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29452148/complete-inhibition-of-fetal-movement-in-the-day-40-pregnant-goat-model-by-the-piperidine-alkaloid-anabasine-but-not-related-alkaloids
#7
B T Green, S T Lee, J W Keele, K D Welch, D Cook, J A Pfister, W R Kem
Four chemically similar alkaloids, anabasine, anabaseine, epibatidine and dimethylphenylpiperazinium (DMPP), are potent nicotinic acetylcholine receptor agonists of fetal muscle nicotinic acetylcholine receptors in human TE-671 cells. Based on results with these cells, we hypothesized that the alkaloids would completely inhibit ultrasound-monitored fetal movement in a goat model. Different, single doses of anabasine, anabaseine, epibatidine, DMPP, or saline control were administered I.V. to pregnant goats on day 40 of gestation and the number of fetal movements per 5 min sample was measured by ultrasound at times 0, 0...
February 13, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29451607/decolorization-of-textile-industry-wastewater-in-solid-state-fermentation-with-peach-palm-bactris-gasipaes-residue
#8
J A Chicatto, K T Rainert, M J Gonçalves, C V Helm, D Altmajer-Vaz, L B B Tavares
In this work we have assessed the decolorization of textile effluents throughout their treatment in a solid-state fermentation (SSF) system. SSF assays were conducted with peach-palm (Bactris gasipaes) residue using the white rot fungus Ganoderma lucidum EF 31. The influence of the dye concentration and of the amounts of peach-palm residue and liquid phase on both the discoloration efficiency and enzyme production was studied. According to our results, independently of experimental conditions employed, laccase was the main ligninolytic enzyme produced by G...
February 15, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/29450757/enhanced-expression-of-ginsenoside-biosynthetic-genes-and-in-vitro-ginsenoside-production-in-elicited-panax-sikkimensis-ban-cell-suspensions
#9
Tanya Biswas, Shiv Shanker Pandey, Deepamala Maji, Vikrant Gupta, Alok Kalra, Manju Singh, Archana Mathur, A K Mathur
Dual metabolite, i.e., ginsenoside and anthocyanin, co-accumulating cell suspensions of Panax sikkimensis were subjected to elicitation with culture filtrates of Serratia marcescens (SD 21), Bacillus subtilis (FL11), Trichoderma atroviridae (TA), and T. harzianum (TH) at 1.25% and 2.5% v/v for 1- and 3-week duration. The fungal-derived elicitors (TA and TH) did not significantly affect biomass accumulation; however, bacterial elicitors (SD 21 and FL11), especially SD 21, led to comparable loss in biomass growth...
February 15, 2018: Protoplasma
https://www.readbyqxmd.com/read/29450742/focused-cardiac-ultrasound-as-a-predictor-of-readmission-in-acute-decompensated-heart-failure
#10
Luke J Laffin, Amit V Patel, Narayan Saha, Julian Barbat, James K Hall, Matthew Cain, Kishan Parikh, Jay Shah, Kirk T Spencer
Acute decompensated heart failure (ADHF) is a common reason for admission to the hospital, and readmission is frequent. Multiple factors contribute to rehospitalizations, but inadequate assessment of volume status leading to persistent congestion is an important factor. We sought to determine if focused cardiac ultrasound (FCU) of the inferior vena cava (IVC), as a surrogate of volume status, would predict readmission of ADHF patients after index hospitalization. Patients admitted with a primary diagnosis of ADHF were prospectively enrolled...
February 15, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29449629/publisher-correction-human-%C3%AE-%C3%AE-t-cells-are-quickly-reconstituted-after-stem-cell-transplantation-and-show-adaptive-clonal-expansion-in-response-to-viral-infection
#11
Sarina Ravens, Christian Schultze-Florey, Solaiman Raha, Inga Sandrock, Melanie Drenker, Linda Oberdörfer, Annika Reinhardt, Inga Ravens, Maleen Beck, Robert Geffers, Constantin von Kaisenberg, Michael Heuser, Felicitas Thol, Arnold Ganser, Reinhold Förster, Christian Koenecke, Immo Prinz
In the version of this article initially published, a source of funding (Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS R12/29 to C.K. and I.P.)) was not included in the Acknowledgments section. The correct statement is as follows: "Supported by Deutsche Forschungsgemeinschaft, (SFB900/B8 to C.K. and I.P.; and PR727/4-1 to I.P.), Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS R12/29 to C.K. and I.P.) and the German Federal Ministry of Education and Research (01EO1302 to C.S.-F., C.K. and I...
February 14, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29448523/mimicking-the-synaptic-weights-and-human-forgetting-curve-using-hydrothermally-grown-nanostructured-cuo-memristor-device
#12
T D Dongale, P S Pawar, R S Tikke, N B Mullani, V B Patil, A M Teli, K V Khot, S V Mohite, A A Bagade, V S Kumbhar, K Y Rajpure, P N Bhosale, R K Kamat, P S Patil
In the present investigation, we have fabricated copper oxide (CuO) thin film memristor by employing a hydrothermal method for neuromorphic application. The X-ray diffraction pattern confirms the films are polycrystalline in nature with the monoclinic crystal structure. The developed devices show analog memory and synaptic property similar to biological neuron. The size dependent synaptic behavior is investigated for as-prepared and annealed CuO memristor. The results suggested that the magnitude of synaptic weights and resistive switching voltages are dependent on the thickness of the active layer...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448040/comparing-the-therapeutic-efficacy-of-different-amphotericin-b-carrying-delivery-systems-against-visceral-leishmaniasis
#13
Débora V C Mendonça, Vívian T Martins, Daniela P Lage, Daniel S Dias, Patrícia A F Ribeiro, Ana Maria R S Carvalho, Anna Letícia T Dias, Carolina K Miyazaki, Daniel Menezes-Souza, Bruno M Roatt, Carlos A P Tavares, José Mário Barichello, Mariana C Duarte, Eduardo A F Coelho
Amphotericin B (Amp) has been well-successfully used to treat against Leishmania infection, although high toxicity has been found in patients. In the present study, Amp was administered in Leishmania infantum-infected BALB/c mice by three distinct delivery systems aiming to compare their efficacy against challenge infection, as well as their side effects in a murine visceral leishmaniasis (VL) model. This product was administered in a Poloxamer P407 (Pluronic ® F127)-based polymeric micelle system (Amp/M), in the Ambisome ® formulation (Lip-Amp) or in a free format (free Amp)...
February 12, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29448010/improved-outcomes-in-management-of-hypoplastic-left-heart-syndrome-associated-with-congenital-diaphragmatic-hernia-an-algorithmic-approach
#14
Kaitlin Balduf, T K Susheel Kumar, Umar Boston, Shyam Sathanandam, Marc V Lee, Tim Jancelewicz, Christopher J Knott-Craig
BACKGROUND: Hypoplastic left heart syndrome (HLHS) is the second most common congenital heart disease associated with congenital diaphragmatic hernia (CDH). The reported survival of neonates with CDH and HLHS is only 1-5%. We review our experience with CDH and HLHS and compare our outcomes to published literature. METHODS: Retrospective review of all neonates with CDH and HLHS at our institution over a 10 year period was performed. The morphology of cardiac and diaphragm defects, clinical course, treatment strategies and outcomes were reviewed and an algorithmic approach is proposed...
February 12, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29447023/designing-a-low-cost-single-supply-ecg-system-for-suppression-of-movement-artifact-from-contaminated-magnetocardiogram
#15
Rajesh Patel, S Sengottuvel, K Gireesan, M P Janawadkar, T S Radhakrishnan
Measurement of the late potentials and His-bundle activity is crucial for many clinical studies using the noncontact and noninvasive magnetocardiography (MCG) technique; these weak signals are extracted by averaging many cardiac cycles aligned using the R-peak of the cardiac cycle identified using an electrocardiography (ECG) lead. ECG is measured simultaneously with MCG using a conventional dual-supply ECG amplifier, which requires either two separate batteries or a single battery with a switching voltage inverter circuit for its proper operation...
February 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29446871/effect-of-management-of-organic-wastes-on-inactivation-of-brassica-nigra-and-fusarium-oxysporum-f-sp-lactucae-using-soil-biosolarization
#16
J D Fernández-Bayo, T E Randall, D R Harrold, Y Achmon, K V Hestmark, J Su, R M Dahlquist-Willard, T R Gordon, J J Stapleton, J S VanderGheynst, C W Simmons
BACKGROUND: Soil biosolarization is a promising alternative to conventional fumigation. Volatile fatty acids (VFAs) produced in the soil through fermentation of amended organic matter can affect pest inactivation during biosolarization. The objective was to determine how soil amended with organic wastes that were partially stabilized through either composting or anaerobic digestion affected the inactivation of Brassica nigra (BN, a weed) and Fusarium oxysporum f. sp. lactucae (FOL, a phytopathogenic fungus)...
February 15, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29446380/pulsating-aurora-from-electron-scattering-by-chorus-waves
#17
S Kasahara, Y Miyoshi, S Yokota, T Mitani, Y Kasahara, S Matsuda, A Kumamoto, A Matsuoka, Y Kazama, H U Frey, V Angelopoulos, S Kurita, K Keika, K Seki, I Shinohara
Auroral substorms, dynamic phenomena that occur in the upper atmosphere at night, are caused by global reconfiguration of the magnetosphere, which releases stored solar wind energy. These storms are characterized by auroral brightening from dusk to midnight, followed by violent motions of distinct auroral arcs that suddenly break up, and the subsequent emergence of diffuse, pulsating auroral patches at dawn. Pulsating aurorae, which are quasiperiodic, blinking patches of light tens to hundreds of kilometres across, appear at altitudes of about 100 kilometres in the high-latitude regions of both hemispheres, and multiple patches often cover the entire sky...
February 14, 2018: Nature
https://www.readbyqxmd.com/read/29446106/impact-of-controlled-attenuation-parameter-on-detecting-fibrosis-using-liver-stiffness-measurement
#18
T Karlas, D Petroff, M Sasso, J-G Fan, Y-Q Mi, V de Lédinghen, M Kumar, M Lupsor-Platon, K-H Han, A C Cardoso, G Ferraioli, W-K Chan, V W-S Wong, R P Myers, K Chayama, M Friedrich-Rust, M Beaugrand, F Shen, J-B Hiriart, S K Sarin, R Badea, H W Lee, P Marcellin, C Filice, S Mahadeva, G L-H Wong, P Crotty, K Masaki, J Bojunga, P Bedossa, V Keim, J Wiegand
BACKGROUND: Liver fibrosis is often accompanied by steatosis, particularly in patients with non-alcoholic fatty liver disease (NAFLD), and its non-invasive characterisation is of utmost importance. Vibration-controlled transient elastography is the non-invasive method of choice; however, recent research suggests that steatosis may influence its diagnostic performance. Controlled Attenuation Parameter (CAP) added to transient elastography enables simultaneous assessment of steatosis and fibrosis...
February 15, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29445217/nonreciprocal-current-from-electron-interactions-in-noncentrosymmetric-crystals-roles-of-time-reversal-symmetry-and-dissipation
#19
Takahiro Morimoto, Naoto Nagaosa
In noncentrosymmetric crystals with broken inversion symmetry [Formula: see text], the I-V (I: current, V: voltage) characteristic is generally expected to depend on the direction of I, which is known as nonreciprocal response and, for example, found in p-n junction. However, it is a highly nontrivial issue in translationally invariant systems since the time-reversal symmetry T plays an essential role, where the two states at crystal momenta k and -k are connected in the band structure. Therefore, it has been considered that the external magnetic field (B) or the magnetic order which breaks the T-symmetry is necessary to realize the nonreciprocal I-V characteristics, i...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444726/resting-state-thalamic-dysconnectivity-in-schizophrenia-and-relationships-with-symptoms
#20
J Ferri, J M Ford, B J Roach, J A Turner, T G van Erp, J Voyvodic, A Preda, A Belger, J Bustillo, D O'Leary, B A Mueller, K O Lim, S C McEwen, V D Calhoun, M Diaz, G Glover, D Greve, C G Wible, J G Vaidya, S G Potkin, D H Mathalon
BACKGROUND: Schizophrenia (SZ) is a severe neuropsychiatric disorder associated with disrupted connectivity within the thalamic-cortico-cerebellar network. Resting-state functional connectivity studies have reported thalamic hypoconnectivity with the cerebellum and prefrontal cortex as well as thalamic hyperconnectivity with sensory cortical regions in SZ patients compared with healthy comparison participants (HCs). However, fundamental questions remain regarding the clinical significance of these connectivity abnormalities...
February 15, 2018: Psychological Medicine
keyword
keyword
77049
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"