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https://www.readbyqxmd.com/read/29684875/toxicoproteomic-analysis-of-human-lung-epithelial-cells-exposed-to-steel-industry-ambient-particulate-matter-pm-reveals-possible-mechanism-of-pm-related-carcinogenesis
#1
S Senthil Kumar, P Muthuselvam, V Pugalenthi, N Subramanian, K M Ramkumar, T Suresh, T Suzuki, P Rajaguru
Toxicoproteomic analysis of steel industry ambient particulate matter (PM) that contain high concentrations of PAHs and metals was done by treating human lung cancer cell-line, A549 and the cell lysates were analysed using quantitative label-free nano LC-MS/MS. A total of 18,562 peptides representing 1576 proteins were identified and quantified, with 196 proteins had significantly altered expression in the treated cells. Enrichment analyses revealed that proteins associated to redox homeostsis, metabolism, and cellular energy generation were inhibited while, proteins related to DNA damage and repair and other stresses were over expressed...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684758/non-enzymatic-sensing-of-glucose-using-screen-printed-electrode-modified-with-novel-synthesized-ceo-2-cuo-core-shell-nanostructure
#2
Dayakar T, K Venkateswara Rao, K Bikshalu, V Malapati, Kishor Kumar Sadasivuni
We fabricated a fourth generation glucose biosensor using CeO2 @CuO core shell nano structure (CeCCS NSs). A simple leave extract of Ocimum tenuiflorum was used to prepare different wt% of 0.2, 04, 0.6, and 0.8 CuO (shell), above 1 wt% of CeO2 (core). The successful formation was confirmed by various characterization techniques like XRD, Uv-Vis, FTIR, SEM and HR-TEM. In the biosensor, 0.4 wt% of CeCCS NSs has shown efficient properties due to its high surface area. The good conductivity and high catalytic activity towards glucose sensing properties were estimated by screen-printed electrode (SPE)...
April 5, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29683555/clinical-obesity-services-in-public-hospitals-in-australia-a-position-statement-based-on-expert-consensus
#3
E Atlantis, N Kormas, K Samaras, P Fahey, P Sumithran, S Glastras, G Wittert, K Fusco, R Bishay, T Markovic, L Ding, K Williams, I Caterson, V Chikani, P Dugdale, J Dixon
We aimed to describe the current state of specialist obesity services for adults with clinically severe obesity in public hospitals in Australia, and to analyse the gap in resources based on expert consensus. We conducted two surveys to collect information about current and required specialist obesity services and resources using open-ended questionnaires. Organizational level data were sought from clinician expert representatives of specialist obesity services across Australia in 2017. Fifteen of 16 representatives of current services in New South Wales (n = 8), Queensland (n = 1), Victoria (n = 2), South Australia (n = 3), and the Australian Capital Territory (n = 1) provided data...
April 23, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29680923/taxonomy-of-the-family-arenaviridae-and-the-order-bunyavirales-update-2018
#4
Piet Maes, Sergey V Alkhovsky, Yīmíng Bào, Martin Beer, Monica Birkhead, Thomas Briese, Michael J Buchmeier, Charles H Calisher, Rémi N Charrel, Il Ryong Choi, Christopher S Clegg, Juan Carlos de la Torre, Eric Delwart, Joseph L DeRisi, Patrick L Di Bello, Francesco Di Serio, Michele Digiaro, Valerian V Dolja, Christian Drosten, Tobiasz Z Druciarek, Jiang Du, Hideki Ebihara, Toufic Elbeaino, Rose C Gergerich, Amethyst N Gillis, Jean-Paul J Gonzalez, Anne-Lise Haenni, Jussi Hepojoki, Udo Hetzel, Thiện Hồ, Ní Hóng, Rakesh K Jain, Petrus Jansen van Vuren, Qi Jin, Miranda Gilda Jonson, Sandra Junglen, Karen E Keller, Alan Kemp, Anja Kipar, Nikola O Kondov, Eugene V Koonin, Richard Kormelink, Yegor Korzyukov, Mart Krupovic, Amy J Lambert, Alma G Laney, Matthew LeBreton, Igor S Lukashevich, Marco Marklewitz, Wanda Markotter, Giovanni P Martelli, Robert R Martin, Nicole Mielke-Ehret, Hans-Peter Mühlbach, Beatriz Navarro, Terry Fei Fan Ng, Márcio Roberto Teixeira Nunes, Gustavo Palacios, Janusz T Pawęska, Clarence J Peters, Alexander Plyusnin, Sheli R Radoshitzky, Víctor Romanowski, Pertteli Salmenperä, Maria S Salvato, Hélène Sanfaçon, Takahide Sasaya, Connie Schmaljohn, Bradley S Schneider, Yukio Shirako, Stuart Siddell, Tarja A Sironen, Mark D Stenglein, Nadia Storm, Harikishan Sudini, Robert B Tesh, Ioannis E Tzanetakis, Mangala Uppala, Olli Vapalahti, Nikos Vasilakis, Peter J Walker, Guópíng Wáng, Lìpíng Wáng, Yànxiăng Wáng, Tàiyún Wèi, Michael R Wiley, Yuri I Wolf, Nathan D Wolfe, Zhìqiáng Wú, Wénxìng Xú, Li Yang, Zuòkūn Yāng, Shyi-Dong Yeh, Yǒng-Zhèn Zhāng, Yàzhōu Zhèng, Xueping Zhou, Chénxī Zhū, Florian Zirkel, Jens H Kuhn
In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. At the same time, the recently established order Bunyavirales was expanded by 3 species. This article presents the updated taxonomy of the family Arenaviridae and the order Bunyavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV) and summarizes additional taxonomic proposals that may affect the order in the near future.
April 21, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29679775/influence-of-side-effects-on-early-therapy-persistence-with-letrozole-in-post-menopausal-patients-with-early-breast-cancer-results-of-the-prospective-evaluate-tm-study
#5
N Nabieva, T Fehm, L Häberle, J de Waal, M Rezai, B Baier, G Baake, H-C Kolberg, M Guggenberger, M Warm, N Harbeck, R Wuerstlein, J-U Deuker, P Dall, B Richter, G Wachsmann, C Brucker, J W Siebers, M Popovic, T Kuhn, C Wolf, H-W Vollert, G-P Breitbach, W Janni, R Landthaler, A Kohls, D Rezek, T Noesselt, G Fischer, S Henschen, T Praetz, V Heyl, T Kühn, T Krauss, C Thomssen, A Hohn, H Tesch, C Mundhenke, A Hein, C C Hack, K Schmidt, E Belleville, S Y Brucker, S Kümmel, M W Beckmann, D Wallwiener, P Hadji, P A Fasching
BACKGROUND: Endocrine treatment (ET) with an aromatase inhibitor (AI) is the treatment of choice in post-menopausal patients with hormone receptor-positive early breast cancer (EBC). However, adverse events (AEs) often lead to treatment discontinuation. This analysis aimed to identify side-effects that lead to patients failing to persist with letrozole treatment. PATIENTS AND METHODS: Post-menopausal hormone receptor-positive EBC patients starting ET with letrozole were enroled in EvAluate-TM, a non-interventional study...
April 18, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29679697/-all-citizens-of-the-world-can-save-a-life-the-world-restart-a-heart-wrah-initiative-starts-in-2018
#6
B W Böttiger, A Lockey, R Aickin, M Castren, A de Caen, R Escalante, K B Kern, S H Lim, V Nadkarni, R W Neumar, J P Nolan, D Stanton, T-L Wang, G D Perkins
No abstract text is available yet for this article.
April 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29679555/mass-spectrometric-measurement-of-urinary-kynurenine-to-tryptophan-ratio-in-children-with-and-without-urinary-tract-infection
#7
Melanie L Yarbrough, Kelleigh E Briden, John V Mitsios, Annette L Weindel, Cindy M Terrill, David A Hunstad, Dennis J Dietzen
BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) catalyzes the first step of tryptophan (Trp) catabolism, yielding kynurenine (Kyn) metabolites. The kynurenine-to-tryptophan (K/T) ratio is used as a surrogate for biological IDO enzyme activity. IDO expression is increased during Escherichia coli urinary tract infection (UTI). Thus, our objective was to develop a method for measurement of Kyn/Trp ratio in human blood and urine and evaluate its use as a biomarker of UTI. METHODS: A mass spectrometric method was developed to measure Trp and Kyn in serum and urine specimens...
April 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29679059/flux-tunable-heat-sink-for-quantum-electric-circuits
#8
M Partanen, K Y Tan, S Masuda, J Govenius, R E Lake, M Jenei, L Grönberg, J Hassel, S Simbierowicz, V Vesterinen, J Tuorila, T Ala-Nissila, M Möttönen
Superconducting microwave circuits show great potential for practical quantum technological applications such as quantum information processing. However, fast and on-demand initialization of the quantum degrees of freedom in these devices remains a challenge. Here, we experimentally implement a tunable heat sink that is potentially suitable for the initialization of superconducting qubits. Our device consists of two coupled resonators. The first resonator has a high quality factor and a fixed frequency whereas the second resonator is designed to have a low quality factor and a tunable resonance frequency...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29677446/classical-optimal-control-for-energy-minimization-based-on-diffeomorphic-modulation-under-observable-response-preserving-homotopy
#9
Micheline B Soley, Andreas Markmann, Victor S Batista
We introduce the so-called 'Classical Optimal Control Optimization' (COCO) method for global energy minimization based on the implementation of the diffeomorphic modulation under observable-response-preserving homotopy (DMORPH) gradient algorithm. A probe particle with time-dependent mass m(t;b) and dipole m(r; t;b) is evolved classically on the potential energy surface V(r) coupled to an electric field E(t;b), as described by the time-dependent density of states represented on a grid, or otherwise as a linear combination of Gaussians generated by the k-means clustering algorithm...
April 20, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29676424/anharmonicity-in-a-double-hydrogen-transfer-reaction-studied-in-a-single-porphycene-molecule-on-a-cu-110-surface
#10
S Liu, D Baugh, K Motobayashi, X Zhao, S V Levchenko, S Gawinkowski, J Waluk, L Grill, M Persson, T Kumagai
Anharmonicity plays a crucial role in hydrogen transfer reactions in hydrogen-bonding systems, which leads to a peculiar spectral line shape of the hydrogen stretching mode as well as highly complex intra/intermolecular vibrational energy relaxation. Single-molecule study with a well-defined model is necessary to elucidate a fundamental mechanism. Recent low-temperature scanning tunnelling microscopy (STM) experiments revealed that the cis ↔ cis tautomerization in a single porphycene molecule on Cu(110) at 5 K can be induced by vibrational excitation via an inelastic electron tunnelling process and the N-H(D) stretching mode couples with the tautomerization coordinate [Kumagai et al...
April 20, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29676361/a-37-year-old-male-with-extensive-cerebral-venous-thrombosis-clinicopathological-correlation-of-a-rare-case
#11
Deepti Mutreja, Rajeev Saxena, T V S V G K Tilak, Vanmalini Tewari, Nikhil Moorchung, Bhaskar Nandi
We present the autopsy findings and differential diagnosis of a 37-year-old immunocompetent male patient who presented primarily with extensive cerebral vein thrombosis and was found to have a rare association with JAK2V617F mutation positivity.
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29674566/erratum-for-the-report-a-precise-measurement-of-the-magnetic-field-in-the-corona-of-the-black-hole-binary-v404-cygni-by-y-dallilar-s-s-eikenberry-a-garner-r-d-stelter-a-gottlieb-p-gandhi-p-casella-v-s-dhillon-t-r-marsh-s-p-littlefair-l-hardy-r-fender-k-mooley
#12
https://www.readbyqxmd.com/read/29673760/tumor-suppressive-functions-of-4-mu-on-breast-cancer-cells-of-different-er-status-regulation-of-hyaluronan-has2-cd44-and-specific-matrix-effectors
#13
Theodoros T Karalis, Paraskevi Heldin, Demitrios H Vynios, Thomas Neill, Simone Buraschi, Renato V Iozzo, Nikos K Karamanos, Spyros S Skandalis
The malignant phenotype of various cancers is linked to enhanced expression of hyaluronan, a pro-angiogenic glycosaminoglycan whose expression is suppressed by 4-methylumbelliferone (4-MU), a non-toxic oral agent used as a dietary supplement to improve health and combat prostate cancer. However, little is known about the effects of hyaluronan inhibition by 4-MU on breast cancer cells. In this study, we investigated the role of 4-MU in mammary carcinoma cells with distinct malignant phenotypes and estrogen receptor (ER) status, a major prognostic factor in the clinical management of breast cancers...
April 16, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29673600/online-drug-information-platform-for-the-public-in-hong-kong-review-of-local-drug-information-use-and-needs
#14
F W T Cheng, S W K So, B W T Fung, W H Hung, V W Y Lee
INTRODUCTION: In view of the popularity of Internet usage in Hong Kong, an interactive web-based drug information platform entitled "Ask My Pharmacist - Online University Led drug Enquiry Platform" (AMPOULE) was launched in 2009 to better serve the needs of drug information in Hong Kong. This paper aimed to evaluate the utility of AMPOULE in improving drug-related knowledge among the public and to reassess the needs of the general public in Hong Kong. METHODS: All enquiries sent via AMPOULE were reviewed...
June 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29672835/report-from-the-fifth-international-consensus-meeting-to-harmonize-core-outcome-measures-for-atopic-eczema-dermatitis-clinical-trials-home-initiative
#15
J R Chalmers, K S Thomas, C Apfelbacher, H C Williams, C A Prinsen, P I Spuls, E Simpson, L A A Gerbens, M Boers, S Barbarot, J F Stalder, K Abuabara, V Aoki, M Ardeleanu, J Armstrong, B Bang, T L Berents, T Burton, L Butler, T Chubachi, A Cresswell-Melville, A DeLozier, L Eckert, L Eichenfield, C Flohr, M Futamura, A Gadkari, E S Gjerde, K F van Halewijn, C Hawkes, L Howells, L Howie, R Humphreys, H A Ishii, Y Kataoka, I Katayama, W Kouwenhoven, S M Langan, Y A Leshem, S Merhand, P Mina-Osorio, H Murota, T Nakahara, F P Nunes, U Nygaard, M Nygårdas, Y Ohya, E Ono, E Rehbinder, N K Rogers, G L E Romeijn, M L A Schuttelaar, A V Sears, M A Simpson, J A Singh, J Srour, B Stuart, Å Svensson, G Talmo, H Talmo, H D Teixeira, J P Thyssen, G Todd, F Torchet, A Volke, L von Kobyletzki, E Weisshaar, A Wollenberg, M Zaniboni
This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12-14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus over the definition of the core domain of long-term control and how to measure it and (ii) to prioritize future areas of research for the measurement of the core domain of quality of life (QoL) in children. Moderated whole-group and small-group consensus discussions were informed by presentations of qualitative studies, systematic reviews and validation studies...
April 19, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29671361/liposomal-quercetin-potentiates-maxi-k-channel-openings-in-smooth-muscles-and-restores-its-activity-after-oxidative-stress
#16
Mariia I Melnyk, Dariia O Dryn, Lina T Al Kury, Alexander V Zholos, Anatoly I Soloviev
The effects of quercetin-loaded liposomes (PCL-Q) and their constituents, that is, free quercetin (Q) and 'empty' phosphatidylcholine vesicles (PCL), on maxi-K channel activity were studied in single mouse ileal myocytes before and after H2 O2 -induced oxidative stress. Macroscopic Maxi-K channel currents were recorded using whole-cell patch clamp techniques, while single BKCa channel currents were recorded in the cell-attached configuration. Bath application of PCL-Q (100 μg/ml of lipid and 3 μg/ml of quercetin) increased single Maxi-K channel activity more than threefold, from 0...
April 19, 2018: Journal of Liposome Research
https://www.readbyqxmd.com/read/29669076/effect-of-lower-energy-higher-fiber-diets-on-pigs-divergently-selected-for-residual-feed-intake-when-fed-higher-energy-lower-fiber-diets
#17
E D Mauch, J M Young, N V L Serão, W L Hsu, J F Patience, B J Kerr, T E Weber, N K Gabler, J C M Dekkers
Residual feed intake (RFI) is the difference between observed and predicted feed intake of an animal, based on growth and maintenance requirements. In Yorkshire pigs, divergent selection for increased (Low RFI) and decreased (High RFI) RFI was carried out over 10 generations (G) while feeding a corn- and soybean-meal-based, higher-energy, lower-fiber (HELF) diet. In G8 to G10, representing 4 replicates, barrows and gilts (n = 649) of the RFI lines were fed the HELF diet and a diet incorporating coproducts that were lower in energy and higher in dietary fiber (LEHF)...
April 14, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29668445/pathobiochemical-mechanisms-relating-iron-homeostasis-with-parameters-of-inflammatory-activity-and-autoimmune-disorders-in-rheumatoid-arthritis
#18
Katya I Stefanova, Ginka T Delcheva, Ana I Maneva, Anastas Z Batalov, Mariela G Geneva-Popova, Rositza V Karalilova, Kiril K Simitchiev
AIM: To find the correlations between the parameters of iron homeostasis, inflammatory activity and autoimmune disorders in rheumatoid arthritis (RA). MATERIALS AND METHODS: The present study included 114 patients with RA and 42 healthy controls. We determined the parameters of iron homeostasis: serum iron, total iron binding capacity (TIBC), ferritin and soluble transferrin receptor (sTfR), the parameters of inflammatory activity: C-reactive protein (CRP), interleukin-6 (IL-6) and prohepcidin, and the parameters of autoimmune disorders: rheumatoid factor (RF), anti-cyclic citrullinated peptide (antiCCP) antibodies and DAS 28...
March 1, 2018: Folia Medica
https://www.readbyqxmd.com/read/29667884/egg-and-banana-sign-a-novel-diagnostic-ct-marker-for-pulmonary-hypertension
#19
Chris L Scelsi, William B Bates, Yulia V Melenevsky, Gyanendra K Sharma, Norman B Thomson, Jayanth H Keshavamurthy
OBJECTIVE: The purpose of this study was to retrospectively determine whether the egg-and-banana sign, defined as the visualization of the main pulmonary artery (PA) at the level of the aortic arch, is a sensitive and specific diagnostic marker for pulmonary hypertension. MATERIALS AND METHODS: A total of 186 patients who, between January 2014 and July 2017, received right heart catheterizations and underwent CT studies that included the aortic arch within 140 days of catheterization were evaluated in this retrospective study...
April 18, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29666409/exposure-to-phthalate-an-endocrine-disrupting-chemical-alters-the-first-trimester-placental-methylome-and-transcriptome-in-women
#20
N M Grindler, L Vanderlinden, R Karthikraj, K Kannan, S Teal, A J Polotsky, T L Powell, I V Yang, T Jansson
Phthalates are known endocrine disruptors and associated with decreased fecundity, pregnancy loss, and adverse obstetrical outcomes, however the underlying mechanisms remain to be established. Environmental factors can influence gene expression and cell function by modifying epigenetic marks, impacting the developing embryo as well as future generations of offspring. The impact of phthalates on placental gene methylation and expression is largely unknown. We studied the effect of maternal phthalate exposure on the human placental DNA methylome and transcriptome...
April 17, 2018: Scientific Reports
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