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https://www.readbyqxmd.com/read/27913983/mobile-health-technology-can-objectively-capture-physical-activity-pa-targets-among-african-american-women-within-resource-limited-communities-the-washington-d-c-cardiovascular-health-and-needs-assessment
#1
S Thomas, L Yingling, J Adu-Brimpong, V Mitchell, C R Ayers, G R Wallen, M Peters-Lawrence, A T Brooks, D M Sampson, K L Wiley, J Saygbe, J Henry, A Johnson, A Graham, L Graham, T M Powell-Wiley
BACKGROUND: Little is understood about using mobile health (mHealth) technology to improve cardiovascular (CV) health among African-American women in resource-limited communities. METHODS: We conducted the Washington, D.C. CV Health and Needs Assessment in predominantly African-American churches in city wards 5, 7, and 8 with the lowest socioeconomic status based on community-based participatory research (CBPR) principles. The assessment measured CV health factors: body mass index (BMI), fasting blood glucose and cholesterol, blood pressure, fruit/vegetable (F/V) intake, physical activity (PA), and smoking...
December 2, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27911851/inherited-variants-affecting-rna-editing-may-contribute-to-ovarian-cancer-susceptibility-results-from-a-large-scale-collaboration
#2
Jennifer B Permuth, Brett Reid, Madalene Earp, Y Ann Chen, Alvaro N A Monteiro, Zhihua Chen, Aocs Study Group, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Adriaan Vanderstichele, Els Van Niewenhuyse, Ignace Vergote, Mary Anne Rossing, Jennifer Anne Doherty, Jenny Chang-Claude, Kirsten Moysich, Kunle Odunsi, Marc T Goodman, Yurii B Shvetsov, Lynne R Wilkens, Pamela J Thompson, Thilo Dörk, Natalia Bogdanova, Ralf Butzow, Heli Nevanlinna, Liisa Pelttari, Arto Leminen, Francesmary Modugno, Robert P Edwards, Roberta B Ness, Joseph Kelley, Florian Heitz, Beth Karlan, Jenny Lester, Susanne K Kjaer, Allan Jensen, Graham Giles, Michelle Hildebrandt, Dong Liang, Karen H Lu, Xifeng Wu, Douglas A Levine, Maria Bisogna, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Shelley S Tworoger, Elizabeth M Poole, Elisa V Bandera, Brooke Fridley, Julie Cunningham, Stacey J Winham, Sara H Olson, Irene Orlow, Line Bjorge, Lambertus A Kiemeney, Leon Massuger, Tanja Pejovic, Melissa Moffitt, Nhu Le, Linda S Cook, Angela Brooks-Wilson, Linda E Kelemen, Jacek Gronwald, Jan Lubinski, Nicolas Wentzensen, Louise A Brinton, Jolanta Lissowska, Hanna Yang, Estrid Hogdall, Claus Hogdall, Lene Lundvall, Paul D P Pharoah, Honglin Song, Ian Campbell, Diana Eccles, Iain McNeish, Alice Whittemore, Valerie McGuire, Weiva Sieh, Joseph Rothstein, Catherine M Phelan, Harvey Risch, Steven Narod, John McLaughlin, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Celeste Leigh Pearce, Anna H Wu, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Joellen M Schildkraut, Jin Q Cheng, Ellen L Goode, Thomas A Sellers
RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypothesized that single nucleotide polymorphisms (SNPs) in ADAR genes modify EOC susceptibility, potentially by altering ovarian tissue gene expression. Using directly genotyped and imputed data from 10,891 invasive EOC cases and 21,693 controls, we evaluated the associations of 5,303 SNPs in ADAD1, ADAR, ADAR2, ADAR3, and SND1...
July 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27911771/stability-folding-dynamics-and-long-range-conformational-transition-of-the-synaptic-t-snare-complex
#3
Xinming Zhang, Aleksander A Rebane, Lu Ma, Feng Li, Junyi Jiao, Hong Qu, Frederic Pincet, James E Rothman, Yongli Zhang
Synaptic soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) couple their stepwise folding to fusion of synaptic vesicles with plasma membranes. In this process, three SNAREs assemble into a stable four-helix bundle. Arguably, the first and rate-limiting step of SNARE assembly is the formation of an activated binary target (t)-SNARE complex on the target plasma membrane, which then zippers with the vesicle (v)-SNARE on the vesicle to drive membrane fusion. However, the t-SNARE complex readily misfolds, and its structure, stability, and dynamics are elusive...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911425/-biometric-parameters-of-vitrectomized-eyes
#4
S V Asatryan, V K Surguch, S I Kharlap, T A Shchegoleva
AIM: To analyze changes in various biometric parameters after vitrectomy. MATERIAL AND METHODS: A total of 50 patients (50 eyes) were followed up. All of them underwent vitrectomy for idiopathic epiretinal fibrosis and macular hole. In addition to the standard ophthalmic examination, we performed a combined ultrasound study and ultrasound biomicroscopy before and after the surgery (at 2-3 weeks and 6 months). Variation statistics was applied to assess the results using the SPSS Statistica 20 software...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27910640/calibration-of-the-microcalorimeter-spectrometer-on-board-the-hitomi-astro-h-observatory-invited
#5
M E Eckart, K R Boyce, G V Brown, M P Chiao, R Fujimoto, D Haas, J-W den Herder, Y Ishisaki, R L Kelley, C A Kilbourne, M A Leutenegger, D McCammon, K Mitsuda, F S Porter, M Sawada, G A Sneiderman, A E Szymkowiak, Y Takei, M Tashiro, M Tsujimoto, C P de Vries, T Watanabe, S Yamada, N Y Yamasaki
The Hitomi Soft X-ray Spectrometer (SXS) was a pioneering non-dispersive imaging x-ray spectrometer with 5 eV FWHM energy resolution, consisting of an array of 36 silicon-thermistor microcalorimeters at the focus of a high-throughput soft x-ray telescope. The instrument enabled astrophysical plasma diagnostics in the 0.3-12 keV band. We introduce the SXS calibration strategy and corresponding ground calibration measurements that took place from 2012-2015, including both the characterization of the microcalorimeter array and measurements of the x-ray transmission of optical blocking filters...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910586/a-novel-method-to-recover-dd-fusion-proton-cr-39-data-corrupted-by-fast-ablator-ions-at-omega-and-the-national-ignition-facility
#6
G D Sutcliffe, L M Milanese, D Orozco, B Lahmann, M Gatu Johnson, F H Séguin, H Sio, J A Frenje, C K Li, R D Petrasso, H-S Park, J R Rygg, D T Casey, R Bionta, D P Turnbull, C M Huntington, J S Ross, A B Zylstra, M J Rosenberg, V Yu Glebov
CR-39 detectors are used routinely in inertial confinement fusion (ICF) experiments as a part of nuclear diagnostics. CR-39 is filtered to stop fast ablator ions which have been accelerated from an ICF implosion due to electric fields caused by laser-plasma interactions. In some experiments, the filtering is insufficient to block these ions and the fusion-product signal tracks are lost in the large background of accelerated ion tracks. A technique for recovering signal in these scenarios has been developed, tested, and implemented successfully...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910557/a-storage-ring-experiment-to-detect-a-proton-electric-dipole-moment
#7
V Anastassopoulos, S Andrianov, R Baartman, S Baessler, M Bai, J Benante, M Berz, M Blaskiewicz, T Bowcock, K Brown, B Casey, M Conte, J D Crnkovic, N D'Imperio, G Fanourakis, A Fedotov, P Fierlinger, W Fischer, M O Gaisser, Y Giomataris, M Grosse-Perdekamp, G Guidoboni, S Hacıömeroğlu, G Hoffstaetter, H Huang, M Incagli, A Ivanov, D Kawall, Y I Kim, B King, I A Koop, D M Lazarus, V Lebedev, M J Lee, S Lee, Y H Lee, A Lehrach, P Lenisa, P Levi Sandri, A U Luccio, A Lyapin, W MacKay, R Maier, K Makino, N Malitsky, W J Marciano, W Meng, F Meot, E M Metodiev, L Miceli, D Moricciani, W M Morse, S Nagaitsev, S K Nayak, Y F Orlov, C S Ozben, S T Park, A Pesce, E Petrakou, P Pile, B Podobedov, V Polychronakos, J Pretz, V Ptitsyn, E Ramberg, D Raparia, F Rathmann, S Rescia, T Roser, H Kamal Sayed, Y K Semertzidis, Y Senichev, A Sidorin, A Silenko, N Simos, A Stahl, E J Stephenson, H Ströher, M J Syphers, J Talman, R M Talman, V Tishchenko, C Touramanis, N Tsoupas, G Venanzoni, K Vetter, S Vlassis, E Won, G Zavattini, A Zelenski, K Zioutas
A new experiment is described to detect a permanent electric dipole moment of the proton with a sensitivity of 10(-29) e ⋅ cm by using polarized "magic" momentum 0.7 GeV/c protons in an all-electric storage ring. Systematic errors relevant to the experiment are discussed and techniques to address them are presented. The measurement is sensitive to new physics beyond the standard model at the scale of 3000 TeV.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910532/improving-the-off-axis-spatial-resolution-and-dynamic-range-of-the-nif-x-ray-streak-cameras-invited
#8
A G MacPhee, A K L Dymoke-Bradshaw, J D Hares, J Hassett, B W Hatch, A L Meadowcroft, P M Bell, D K Bradley, P S Datte, O L Landen, N E Palmer, K W Piston, V V Rekow, T J Hilsabeck, J D Kilkenny
We report simulations and experiments that demonstrate an increase in spatial resolution of the NIF core diagnostic x-ray streak cameras by at least a factor of two, especially off axis. A design was achieved by using a corrector electron optic to flatten the field curvature at the detector plane and corroborated by measurement. In addition, particle in cell simulations were performed to identify the regions in the streak camera that contribute the most to space charge blurring. These simulations provide a tool for convolving synthetic pre-shot spectra with the instrument function so signal levels can be set to maximize dynamic range for the relevant part of the streak record...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910445/the-advanced-ligo-photon-calibrators
#9
S Karki, D Tuyenbayev, S Kandhasamy, B P Abbott, T D Abbott, E H Anders, J Berliner, J Betzwieser, C Cahillane, L Canete, C Conley, H P Daveloza, N De Lillo, J R Gleason, E Goetz, K Izumi, J S Kissel, G Mendell, V Quetschke, M Rodruck, S Sachdev, T Sadecki, P B Schwinberg, A Sottile, M Wade, A J Weinstein, M West, R L Savage
The two interferometers of the Laser Interferometry Gravitational-wave Observatory (LIGO) recently detected gravitational waves from the mergers of binary black hole systems. Accurate calibration of the output of these detectors was crucial for the observation of these events and the extraction of parameters of the sources. The principal tools used to calibrate the responses of the second-generation (Advanced) LIGO detectors to gravitational waves are systems based on radiation pressure and referred to as photon calibrators...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910409/development-of-miniaturized-spectroscopically-assisted-penning-gauges-for-fractional-helium-and-hydrogen-neutral-pressure-measurements
#10
K Flesch, T Kremeyer, O Schmitz, V Soukhanovskii, U Wenzel
Direct measurements of the helium (He) fractional neutral pressure in the neutral gas around fusion devices is challenging because of the small mass difference between the abundant D2 molecules and the He ash which will be produced by deuterium-tritium fusion. To study He exhaust, an in situ Penning gauge system is being developed at UW-Madison that is optimized for good pressure and high spectroscopic sensitivity. Three different anode geometries have been studied regarding their vacuum electrostatic fields, light output, and ion current...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910389/overview-of-diagnostic-performance-and-results-for-the-first-operation-phase-in-wendelstein-7-x-invited
#11
M Krychowiak, A Adnan, A Alonso, T Andreeva, J Baldzuhn, T Barbui, M Beurskens, W Biel, C Biedermann, B D Blackwell, H S Bosch, S Bozhenkov, R Brakel, T Bräuer, B Brotas de Carvalho, R Burhenn, B Buttenschön, A Cappa, G Cseh, A Czarnecka, A Dinklage, P Drews, A Dzikowicka, F Effenberg, M Endler, V Erckmann, T Estrada, O Ford, T Fornal, H Frerichs, G Fuchert, J Geiger, O Grulke, J H Harris, H J Hartfuß, D Hartmann, D Hathiramani, M Hirsch, U Höfel, S Jabłoński, M W Jakubowski, J Kaczmarczyk, T Klinger, S Klose, J Knauer, G Kocsis, R König, P Kornejew, A Krämer-Flecken, N Krawczyk, T Kremeyer, I Książek, M Kubkowska, A Langenberg, H P Laqua, M Laux, S Lazerson, Y Liang, S C Liu, A Lorenz, A O Marchuk, S Marsen, V Moncada, D Naujoks, H Neilson, O Neubauer, U Neuner, H Niemann, J W Oosterbeek, M Otte, N Pablant, E Pasch, T Sunn Pedersen, F Pisano, K Rahbarnia, L Ryć, O Schmitz, S Schmuck, W Schneider, T Schröder, H Schuhmacher, B Schweer, B Standley, T Stange, L Stephey, J Svensson, T Szabolics, T Szepesi, H Thomsen, J-M Travere, H Trimino Mora, H Tsuchiya, G M Weir, U Wenzel, A Werner, B Wiegel, T Windisch, R Wolf, G A Wurden, D Zhang, A Zimbal, S Zoletnik
Wendelstein 7-X, a superconducting optimized stellarator built in Greifswald/Germany, started its first plasmas with the last closed flux surface (LCFS) defined by 5 uncooled graphite limiters in December 2015. At the end of the 10 weeks long experimental campaign (OP1.1) more than 20 independent diagnostic systems were in operation, allowing detailed studies of many interesting plasma phenomena. For example, fast neutral gas manometers supported by video cameras (including one fast-frame camera with frame rates of tens of kHz) as well as visible cameras with different interference filters, with field of views covering all ten half-modules of the stellarator, discovered a MARFE-like radiation zone on the inboard side of machine module 4...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910388/fluence-compensated-down-scattered-neutron-imaging-using-the-neutron-imaging-system-at-the-national-ignition-facility
#12
D T Casey, P L Volegov, F E Merrill, D H Munro, G P Grim, O L Landen, B K Spears, D N Fittinghoff, J E Field, V A Smalyuk
The Neutron Imaging System at the National Ignition Facility is used to observe the primary ∼14 MeV neutrons from the hotspot and down-scattered neutrons (6-12 MeV) from the assembled shell. Due to the strong spatial dependence of the primary neutron fluence through the dense shell, the down-scattered image is convolved with the primary-neutron fluence much like a backlighter profile. Using a characteristic scattering angle assumption, we estimate the primary neutron fluence and compensate the down-scattered image, which reveals information about asymmetry that is otherwise difficult to extract without invoking complicated models...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910349/multi-channel-poloidal-correlation-reflectometry-on-experimental-advanced-superconducting-tokamak
#13
H Qu, T Zhang, X Han, H M Xiang, F Wen, K N Geng, Y M Wang, D F Kong, J Q Cai, C B Huang, Y Gao, X Gao, S Zhang
A new multi-channel poloidal correlation reflectometry is developed at Experimental Advanced Superconducting Tokamak. Eight dielectric resonator oscillators with frequencies of 12.5 GHz, 13.5 GHz, 14.5 GHz, 15 GHz, 15.5 GHz, 16 GHz, 17 GHz, and 18 GHz are used as sources. Signals from the sources are up-converted to V band using active quadruplers and then coupled together. The output waves are launched by one single antenna after passing through a 20 dB directional coupler which can provide the reference signal...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910317/cryogenic-setup-for-trapped-ion-quantum-computing
#14
M F Brandl, M W van Mourik, L Postler, A Nolf, K Lakhmanskiy, R R Paiva, S Möller, N Daniilidis, H Häffner, V Kaushal, T Ruster, C Warschburger, H Kaufmann, U G Poschinger, F Schmidt-Kaler, P Schindler, T Monz, R Blatt
We report on the design of a cryogenic setup for trapped ion quantum computing containing a segmented surface electrode trap. The heat shield of our cryostat is designed to attenuate alternating magnetic field noise, resulting in 120 dB reduction of 50 Hz noise along the magnetic field axis. We combine this efficient magnetic shielding with high optical access required for single ion addressing as well as for efficient state detection by placing two lenses each with numerical aperture 0.23 inside the inner heat shield...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910115/an-expert-consensus-definition-of-failure-of-a-treatment-to-provide-adequate-relief-f-par-for-chronic-constipation-an-international-delphi-survey
#15
J Tack, H Boardman, P Layer, I Schiefke, D Jayne, C Scarpignato, M Fox, T Frieling, P Ducrotte, S Hamdy, K Gill, C Ciriza de Los Rios, R Felt-Bersma, D De Looze, V Stanghellini, A Mohr Drewes, M Simrén, C Pehl, T Hoheisel, A Leodolter, E Rey, J Dalrymple, A Emmanuel
BACKGROUND: As treatments for constipation become increasingly available, it is important to know when to progress along the treatment algorithm if the patient is not better. AIM: To establish the definition of failure of a treatment to provide adequate relief (F-PAR) to support this management and referral process in patients with chronic constipation. METHODS: We conducted an international Delphi Survey among gastroenterologists and general practitioners with a special interest in chronic constipation...
December 1, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27909963/pathogenic-features-of-dysuria-in-young-women-with-secondary-amenorrhea-caused-by-body-weight-loss
#16
N V Shelkovnikova, A I Neimark, T S Taranina, A K Pichigina, O P Molodyh, E L Lushnikova
We examined 11 women aged 19-26 years (mean age 22.5±3.5 years) with secondary amenorrhea complaining frequent urination over 1.5 years and repeatedly, but unsuccessful treated for overactive bladder and chronic cystitis. The rare cause of sustained urination disorders in young female patients of reproductive age was established: development of secondary amenorrhea caused by weight loss ("cosmetic" amenorrhea) with subsequent estrogene deficit and urogenital atrophy. Morphological examination of the bladder mucosa, an important clue to the diagnosis, helps to identify the true cause of dysuria, urogenital atrophy of the bladder mucosa, in secondary ("cosmetic") amenorrhea, and determine future course of etiopathogenic treatment of sustained dysuria in young women...
December 2, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27909396/the-eye-as-a-biomarker-for-alzheimer-s-disease
#17
REVIEW
Jeremiah K H Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Vickie H Y Wong, Nicolas Currier, Jamie Mullen, Bang V Bui, Christine T O Nguyen
Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. It is the leading cause of dementia and the number of cases are projected to rise in the next few decades. Pathological hallmarks of AD include the presence of hyperphosphorylated tau and amyloid protein deposition. Currently, these pathological biomarkers are detected either through cerebrospinal fluid analysis, brain imaging or post-mortem. Though effective, these methods are not widely available due to issues such as the difficulty in acquiring samples, lack of infrastructure or high cost...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27909269/chaperones-and-intimate-physical-examinations-what-do-male-and-female-patients-want
#18
V C Fan, H T Choy, G Yj Kwok, H G Lam, Q Y Lim, Y Y Man, C K Tang, C C Wong, Y F Yu, G Kk Leung
INTRODUCTION: Many studies of patients' perception of a medical chaperone have focused on female patients; that of male patients are less well studied. Moreover, previous studies were largely based on patient populations in English-speaking countries. Therefore, this study was conducted to investigate the perception and attitude of male and female Chinese patients to the presence of a chaperone during an intimate physical examination. METHODS: A cross-sectional guided questionnaire survey was conducted on a convenient sample of 150 patients at a public teaching hospital in Hong Kong...
December 2, 2016: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/27907279/development-of-norms-for-executive-functions-in-typically-developing-indian-urban-preschool-children-and-its-association-with-nutritional-status
#19
Sumithra Selvam, Tinku Thomas, Priya Shetty, K Thennarasu, Vijaya Raman, Deepti Khanna, Ruchika Mehra, Anura V Kurpad, Krishnamachari Srinivasan
Executive functions (EFs) are essential and important for achieving success in children's everyday lives and play a fundamental role in children's cognitive, academic, social, emotional and behavioral functioning. A cross-sectional study was carried out to develop age- and sex-specific norms for EFs using the Behavior Rating Inventory of Executive Function - Preschool Version (BRIEF-P) among 2- to 5-year-olds from urban Bangalore, India. In addition, the association between EFs and anthropometric measures, a marker of nutritional status, is also examined...
December 1, 2016: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/27907215/cd8-t-cells-induce-fatal-brainstem-pathology-during-cerebral-malaria-via-luminal-antigen-specific-engagement-of-brain-vasculature
#20
Phillip A Swanson, Geoffrey T Hart, Matthew V Russo, Debasis Nayak, Takele Yazew, Mirna Peña, Shahid M Khan, Chris J Janse, Susan K Pierce, Dorian B McGavern
Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that results in thousands of deaths each year, mostly in African children. The in vivo mechanisms underlying this fatal condition are not entirely understood. Using the animal model of experimental cerebral malaria (ECM), we sought mechanistic insights into the pathogenesis of CM. Fatal disease was associated with alterations in tight junction proteins, vascular breakdown in the meninges / parenchyma, edema, and ultimately neuronal cell death in the brainstem, which is consistent with cerebral herniation as a cause of death...
December 2016: PLoS Pathogens
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