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transcription factor 7-like 2

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https://www.readbyqxmd.com/read/29780592/preleukemic-and-second-hit-mutational-events-in-an-acute-myeloid-leukemia-patient-with-a-novel-germline-runx1-mutation
#1
Isaac Ks Ng, Joanne Lee, Christopher Ng, Bustamin Kosmo, Lily Chiu, Elaine Seah, Michelle Meng Huang Mok, Karen Tan, Motomi Osato, Wee-Joo Chng, Benedict Yan, Lip Kun Tan
Background: Germline mutations in the RUNX1 transcription factor give rise to a rare autosomal dominant genetic condition classified under the entity: Familial Platelet Disorders with predisposition to Acute Myeloid Leukaemia (FPD/AML). While several studies have identified a myriad of germline RUNX1 mutations implicated in this disorder, second-hit mutational events are necessary for patients with hereditary thrombocytopenia to develop full-blown AML. The molecular picture behind this process remains unclear...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29775741/replacement-of-fishmeal-by-spirulina-arthrospira-platensis-affects-growth-immune-related-gene-expression-in-gibel-carp-carassius-auratus-gibelio-var-cas-iii-and-its-challenge-against-aeromonas-hydrophila-infection
#2
Shenping Cao, Peiyu Zhang, Tao Zou, Shuzhan Fei, Dong Han, Junyan Jin, Haokun Liu, Yunxia Yang, Xiaoming Zhu, Shouqi Xie
The present study examined the effect of dietary spirulina, Arthrospira platensis on growth performance, blood physiological indices, immune-related gene expressions and resistance of juvenile gibel carp against Aeromonas hydrophila infection. Four isonitrogenous (360 g kg-1 ) and isolipidic (90 g kg-1 ) diets were formulated with containing different levels of spirulina powder of 0 g (SP0, the control diet), 3.38 g (SP3.38), 6.76 g (SP6.76) and 13.52 g (SP13.52) per 100 g diet to replace 0%, 25%, 50% and 100% of fishmeal protein, respectively...
May 15, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29772800/identification-and-expression-of-mirnas-related-to-female-flower-induction-in-walnut-juglans-regia-l
#3
Li Zhou, Shaowen Quan, Hang Xu, Li Ma, Jianxin Niu
Flower induction is an essential stage in walnut ( Juglans regia L.) trees, directly affecting yield, yield stability, fruit quality and commodity value. The objective of this study was to identify miRNAs related to female flower induction via high-throughput sequencing and bioinformatics analysis. A total of 123 miRNAs were identified including 51 known miRNAs and 72 novel miRNAs. Differential expression was observed in 19 of the known miRNAs and 34 of the novel miRNAs. Twelve miRNAs were confirmed by RT-qPCR...
May 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29771404/mmp-2-participates-in-the-sclera-of-guinea-pig-with-form-deprivation-myopia-via-igf-1-stat3-pathway
#4
Y-X Liu, Y Sun
OBJECTIVE: To investigate the expression changes of MMP-2 (matrix metalloproteinases-2) mediated by IGF-1 (insulin-like growth factors-1) STAT3 (signal transducer and activator of transcription 3) pathway in the sclera of the form-deprivation myopia guinea pigs. MATERIALS AND METHODS: Twenty-four three-week-old guinea pigs were randomly divided into 4 groups: group A (Control), B, C and D. Guinea pigs in group A were sacrificed after 21 days without any special treatment...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29764544/-effects-of-peroxisome-proliferator-activated-receptor-%C3%AE-toll-like-receptor-4-tumor-necrosis-factor-%C3%AE-targeted-pathway-on-hyperglycemia-induced-myocardium-inflammation-and-oxidative-stress
#5
Changle Liu, Ruimeng Liu, Xiaohan Wu, Peize Tan, Huaying Fu, Xinghua Wang, Tong Liu, Guangping Li
OBJECTIVE: To investigate the potential effects and mechanism on peroxisome proliferator-activated receptor γ-toll-like receptor 4-tumor necrosis factor-α (PPARγ-TLR4-TNF-α) targeted pathway on hyperglycemia induced myocardium inflammation and oxidative stress. METHODS: Thirty-two Japanese healthy adult rabbits were randomly divided into four groups with 8 rabbits in each group: normal control group (NC group), diabetes mellitus group (DM group), diabetes mellitus + pioglitazone 4 mg×kg-1 ×d-1 and 8 mg×kg-1 ×d-1 groups (DM+PGZ 4 mg and 8 mg groups)...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29743490/transcriptomic-analysis-of-crustacean-molting-gland-y-organ-regulation-via-the-mtor-signaling-pathway
#6
S Shyamal, S Das, A Guruacharya, D L Mykles, D S Durica
The intermolt crustacean Y-organ (YO) maintains a basal state mediated by pulsatile release of molt inhibiting hormone (MIH), a neuropeptide produced in the eyestalk ganglia, inhibiting YO ecdysteroidogenesis. Reduction of MIH results in YO activation and the animal enters premolt. In the crab, Gecarcinus lateralis, molting was induced by eyestalk ablation (ESA). ESA animals were injected with either rapamycin, an mTOR inhibitor, or DMSO vehicle at Day 0. YOs were harvested at 1, 3, and 7 days post-ESA and processed for high throughput RNA sequencing...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29733821/mir-182-enhances-acute-kidney-injury-by-promoting-apoptosis-involving-the-targeting-and-regulation-of-tcf7l2-wnt-%C3%AE-catenins-pathway
#7
Huicong Li, Yali Ma, Baoping Chen, Jun Shi
Acute kidney injury (AKI)is a sudden decay in renal function leading to increasing morbidity and mortality. miR-182 has been reported to be actively involved in kidney diseases. However, the function and molecular mechanism of miR-182 in AKI still need to be elucidated. The levels of serum creatinine (SCr), blood urea nitrogen (BUN), and urine Kim-1 in I/R-induced rat AKI model were detected by a Beckman Autoanalyzer. miR-182 and transcription factor 7-like-2 (TCF7L2) mRNA expression were measured by qRT-PCR...
May 4, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29730925/broccoli-sprout-extract-alleviates-alcohol-induced-oxidative-stress-and-endoplasmic-reticulum-stress-in-c57bl-6-mice
#8
Peng Lei, Wei Zhao, Bo Pang, Xiuli Yang, Bao-Long Li, Minghua Ren, Yu-Juan Shan
The potential efficacy of sulforaphane in protecting alcohol-induced hepatic injury in vivo and its underlying mechanism was investigated. Male C57BL/6 mice were orally administrated with broccoli sprout extract (BSE) containing sulforaphane (7.6, 25.2, 50.4 mg/kg.bw) once a day for 14 days. At the 13th day, mice were challenged with alcohol (5g/kg.bw) every 12 h for 3 times, which increased malondialdehyde (MDA) levels (4.44±1.24 nmol/mg prot, p<0.01) in liver. Our results showed that low, medium and high dose BSE markedly reversed the decrease of antioxidant capacity through enhancing glutathione (GSH) (2...
May 6, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29713980/chop-caspase-3-signal-pathway-involves-in-mitigative-effect-of-selenium-on-lead-induced-apoptosis-via-endoplasmic-reticulum-pathway-in-chicken-testes
#9
He Huang, Yang An, Wanying Jiao, Jinghan Wang, Shu Li, Xiaohua Teng
Lead (Pb) is an environmental pollutant. Selenium (Se) has alleviative effect on Pb poisoning. However, mitigative effect of Se on Pb-induced apoptosis has not been unclear via endoplasmic reticulum (ER) pathway in chicken testes. The aim of this study was to investigate mitigative effect of Se on apoptosis induced by Pb poisoning via ER pathway in chicken testes. Sixty male chickens (7-day-old) were randomly divided into the control group offered drinking water (DW) and basic diet (BD) (0.49 mg/kg Se), the Se group offered DW and BD containing Na2 SeO3 (SeBD) (1...
April 30, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29703178/extra-capsular-growth-of-lymph-node-metastasis-correlates-with-poor-prognosis-and-high-sox9-expression-in-gastric-cancer
#10
Helena Link, Martin Angele, Miriam Schüller, Petra Ganschow, Lena Machetanz, Markus Guba, Jens Werner, Thomas Kirchner, Jens Neumann
BACKGROUND: Extra-capsular growth (ECG) describes the extension of neoplastic cells beyond the lymph node capsule. Aim of this study was to investigate the prognostic value of ECG and its association with a stem cell like phenotype indicated by expression of the transcription factor SOX9 in gastric cancer. METHODS: By histological evaluation, 199 patients with nodal positive gastric cancer or adeoncarcinoma of the esophageal-gastric junction (AEG) were divided into two groups according to the presence (ECG) or absence (ICG) of extracapsular growth in at least one nodal metastasis...
April 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29690740/-effects-of-exogenous-high-mobility-group-protein-box-1-on-angiogenesis-in-ischemic-zone-of-early-scald-wounds-of-rats
#11
L Dai, X Guo, H J Huang, X M Liao, X Q Luo, D Li, H Zhou, X C Gao, M Y Tan
Objective: To observe effects of exogenous high mobility group protein box 1 (HMGB1) on angiogenesis in ischemic zone of early scald wounds of rats. Methods: Thirty-six Sprague-Dawley rats were divided into HMGB1 group and simple scald (SS) group according to the random number table, with 18 rats in each group. Comb-like copper mould was placed on the back of rats for 20 s after being immersed in 100 ℃ hot water for 3 to 5 min to make three ischemic zones of wound. Immediately after scald, rats in HMGB1 group were subcutaneously injected with 0...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29680643/phosphorylation-of-nuclear-factor-erythroid-2-like-2-nfe2l2-in-mammary-tissue-of-holstein-cows-during-the-periparturient-period-is-associated-with-mrna-abundance-of-antioxidant-gene-networks
#12
L Q Han, Z Zhou, Y Ma, F Batistel, J S Osorio, J J Loor
Changes in the production of reactive oxygen species in the mammary gland of dairy cows during the periparturient period could lead to oxidative stress and potentially impair mammary function. Phosphorylation of the transcription factor nuclear factor erythroid 2-like 2 (NFE2L2), also known as nuclear factor-E2-related factor 2, controls mRNA abundance of genes encoding antioxidant proteins and enzymes. The hypothesis was that NFE2L2 phosphorylation status and target gene mRNA abundance in the mammary gland of dairy cows is altered around parturition...
April 18, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29671785/activation-of-er-stress-dependent-mir-216b-has-a-critical-role-in-salvia-miltiorrhiza-ethanol-extract-induced-apoptosis-in-u266-and-u937-cells
#13
Changmin Kim, Hyo-Sook Song, Hojung Park, Bonglee Kim
Although Salvia miltiorrhiza has been reported to have anti-cancer mechanisms, such as caspase activation, cell cycle arrest, an anti-angiogenesis effect, and Bcl-2 family regulation, its underlying mechanism of endoplasmic reticulum (ER) stress-mediated apoptosis has never been demonstrated. Thus, in this current study, ER stress-related apoptosis via miR-216b of the ethanol extract of Salvia miltiorrhiza (SM) is elucidated for the first time. SM treatment inhibited the viability of U266 and U937 cells in a concentration-dependent manner...
April 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29620186/the-transcription-factor-7-like-2%C3%A2-binding-protein-tip5-activates-%C3%AE-%C3%A2-catenin-transcription-factor-signaling-in-hepatocellular-carcinoma
#14
Chushi Li, Wei Wu, Hongmei Ding, Qingyang Li, Kangkang Xie
Aberrant activation of β‑catenin/transcription factor 7 like 2 (TCF7L2) signaling is frequently observed during the progression of hepatocellular carcinoma (HCC). However, regulation of the nuclear β‑catenin/TCF7L2 complex remains largely unknown. In the present study, immunoprecipitation and glutathione S‑transferase pull‑down assays identified transcription termination factor‑1 interacting protein 5 (TIP5) as a binding partner of TCF7L2. TIP5 activated β‑catenin/TCF7L2 signaling by enhancing the interaction between β‑catenin and TCF7L2...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29605311/nuclear-factor-like-factor-2-antioxidant-activation-through-the-action-of-ataxia-telangiectasia-mutated-serine-threonine-kinase-is-essential-to-counteract-oxidative-stress-in-bovine-mammary-epithelial-cells
#15
Y F Ma, Z H Wu, M Gao, J J Loor
Nuclear factor (erythroid-derived 2)-like factor 2 (NFE2L2, formerly Nrf2) is a transcription factor that binds to the antioxidant response element (ARE) in the upstream promoter region of various antioxidant-responsive genes. Hence, at least in nonruminants, the NFE2L2-ARE signaling pathway plays an important role in the cellular antioxidant defense system. Whether oxidative stress in bovine mammary epithelial cells alters NFE2L2 or the NFE2L2-ARE pathway is unclear. Therefore, the objective of this study was to examine the response in NFE2L2- and NFE2L2-ARE-related components in bovine mammary epithelial cells (BMEC) under oxidative stress...
March 28, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29601828/identification-of-variants-in-ret-and-ihh-pathway-members-in-a-large-family-with-history-of-hirschsprung-disease
#16
Y Sribudiani, R K Chauhan, M M Alves, L Petrova, E Brosens, C Harrison, T Wabbersen, B M de Graaf, T Rügenbrink, G Burzynski, R W W Brouwer, W F J van IJcken, S M Maas, A de Klein, J Osinga, B J L Eggen, A J Burns, A S Brooks, I T Shepherd, R M W Hofstra
BACKGROUND & AIMS: Hirschsprung disease (HSCR) is an inherited congenital disorder characterized by absence of enteric ganglia in the distal part of the gut. Variants in ret proto-oncogene (RET) have been associated with up to 50% of familial and 35% of sporadic cases. We searched for variants that affect disease risk in a large, multi-generational family with history of HSCR in a linkage region previously associated with the disease (4q31.3-q32.3) and exome wide. METHODS: We performed exome sequencing analyses of a family in the Netherlands with 5 members diagnosed with HSCR and 2 members diagnosed with functional constipation...
March 27, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29568881/liraglutide-improves-hepatic-insulin-resistance-via-the-canonical-wnt-signaling-pathway
#17
Yu Qin, Min Chen, Yan Yang, Xin-Rong Zhou, Shi-Ying Shao, Dao-Wen Wang, Gang Yuan
Liraglutide, a modified form of glucagon‑like peptide‑1 (GLP‑1), is used in the treatment of diabetes mellitus. However, the underlying mechanism by which liraglutide improves liver insulin resistance remains to be elucidated. The proto‑oncogene Wnt (Wnt) signaling pathway has been reported to be associated with glucose and lipid metabolism. Using in vivo and in vitro models of diabetes and insulin resistance, it was investigated whether the beneficial effects of liraglutide on liver glucose metabolism are mediated by the Wnt signaling pathway...
March 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29565478/the-significant-role-of-atg5-in-the-maintenance-of-normal-functions-of-mc3t3-e1-osteoblast
#18
Y-M Weng, C-R Ke, J-Z Kong, H Chen, J-J Hong, D-S Zhou
OBJECTIVE: To observe the effects of autophagy-related gene 5 (ATG5) on the proliferation, differentiation, and apoptosis of Mc3T3-E1 osteoblast as well as the effects of ATG5 on apoptosis of osteoblasts under the conditions of non-oxidative stress and oxidative stress. MATERIALS AND METHODS: ATG5 overexpressing and silencing cell lines were established in this experiment with lentiviral vector and transcription activator-like effect or nuclease (Talen) technique, respectively, using Mc3T3-E1 cells...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29559889/endoplasmic-reticulum-stress-in-spinal-cord-contributes-to-the-development-of-morphine-tolerance
#19
Daiqiang Liu, Yaqun Zhou, Yawen Peng, Peng Su, Zheng Li, Qiaoqiao Xu, Ye Tu, Xuebi Tian, Hui Yang, Zhen Wu, Wei Mei, Feng Gao
Morphine tolerance remains an intractable problem, which hinders its prolonged use in clinical practice. Endoplasmic reticulum (ER) stress has been proved to play a fundamental role in the pathogenesis of Alzheimer's disease, diabetes, atherosclerosis, cancer, etc. In this study, we provide the first direct evidence that ER stress may be a significant driver of morphine tolerance. Binding immunoglobulin protein (BiP), the ER stress marker, was significantly upregulated in neurons in spinal dorsal horn in rats being treated with morphine for 7 days...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29549603/low-grade-neuroinflammation-due-to-chronic-sleep-deprivation-results-in-anxiety-and-learning-and-memory-impairments
#20
Shaffi Manchanda, Harpal Singh, Taranjeet Kaur, Gurcharan Kaur
Chronic sleep loss/fragmentation prevalent in the current 24/7 society is associated with irreversible consequences on health and overall wellbeing. Various studies have well documented the ill effects of acute sleep loss on cognitive functions of individuals; however, the underlying mechanism behind the chronic sleep loss is yet to be explored. The present study was aimed to investigate whether chronic sleep deprivation (CSD) triggers anxiety-like behaviour and memory decline in male Wistar rats. Rats were sleep deprived by placing them over slowly rotating drum (2 rpm) for 18 h (between 4 pm and 10 am) followed by 6 h of recovery sleep for 21 consecutive days...
March 16, 2018: Molecular and Cellular Biochemistry
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