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transcription factor 7-like 2

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https://www.readbyqxmd.com/read/28932635/colony-stimulating-factor-1-induced-aif1-expression-in-tumor-associated-macrophages-enhances-the-progression-of-hepatocellular-carcinoma
#1
Hao Cai, Xiao-Dong Zhu, Jian-Yang Ao, Bo-Gen Ye, Yuan-Yuan Zhang, Zong-Tao Chai, Cheng-Hao Wang, Wen-Kai Shi, Man-Qing Cao, Xiao-Long Li, Hui-Chuan Sun
M2-polarized (alternatively activated) macrophages play an important role in the progression of hepatocellular carcinoma (HCC). Allograft inflammatory factor 1 (AIF1) is overexpressed in M2-polarized macrophages. This study explored the role of AIF1 in tumor-associated macrophages in HCC. Macrophages were stimulated with colony-stimulating factor 1 (CSF1) to characterize the regulatory pathway of AIF1 in macrophages. The chromatin immunoprecipitation and luciferase reporter gene assay were conducted to examine transcription factors associated with AIF1 expression...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28903739/evolving-dna-methylation-and-gene-expression-markers-of-b-cell-chronic-lymphocytic-leukemia-are-present-in-pre-diagnostic-blood-samples-more-than-10%C3%A2-years-prior-to-diagnosis
#2
Panagiotis Georgiadis, Irene Liampa, Dennie G Hebels, Julian Krauskopf, Aristotelis Chatziioannou, Ioannis Valavanis, Theo M C M de Kok, Jos C S Kleinjans, Ingvar A Bergdahl, Beatrice Melin, Florentin Spaeth, Domenico Palli, R C H Vermeulen, J Vlaanderen, Marc Chadeau-Hyam, Paolo Vineis, Soterios A Kyrtopoulos
BACKGROUND: B-cell chronic lymphocytic leukemia (CLL) is a common type of adult leukemia. It often follows an indolent course and is preceded by monoclonal B-cell lymphocytosis, an asymptomatic condition, however it is not known what causes subjects with this condition to progress to CLL. Hence the discovery of prediagnostic markers has the potential to improve the identification of subjects likely to develop CLL and may also provide insights into the pathogenesis of the disease of potential clinical relevance...
September 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28886135/differential-regulation-of-innate-immune-cytokine-production-through-pharmacological-activation-of-nuclear-factor-erythroid-2-related-factor-2-nrf2-in-burn-patient-immune-cells-and-monocytes
#3
Timothy K Eitas, Wesley Stepp, Lucas Sjeklocha, Clayton Long, Caitlin Riley, James Callahan, Yolanda Sanchez, Peter Gough, Laquanda Knowlin, David van Duin, Shiara Ortiz-Pujols, Samuel Jones, Robert Maile, Zhi Hong, Scott Berger, Bruce Cairns
Burn patients suffer from immunological dysfunction for which there are currently no successful interventions. Similar to previous observations, we find that burn shock patients (≥15% Total Burn Surface Area (TBSA) injury) have elevated levels of the innate immune cytokines Interleukin-6 (IL-6) and Monocyte Chemoattractant Protein-1 (MCP-1)/CC-motif Chemokine Ligand 2(CCL2) early after hospital admission (0-48 Hours Post-hospital Admission (HPA). Functional immune assays with patient Peripheral Blood Mononuclear Cells (PBMCs) revealed that burn shock patients (≥15% TBSA) produced elevated levels of MCP-1/CCL2 after innate immune stimulation ex vivo relative to mild burn patients...
2017: PloS One
https://www.readbyqxmd.com/read/28886098/molecular-and-biochemical-responses-of-hypoxia-exposure-in-atlantic-croaker-collected-from-hypoxic-regions-in-the-northern-gulf-of-mexico
#4
Md Saydur Rahman, Peter Thomas
A major impact of global climate change has been the marked increase worldwide in the incidence of coastal hypoxia (dissolved oxygen, DO<2.0 mg l-1). However, the extent of hypoxia exposure to motile animals such as fish collected from hypoxic waters as well as their molecular and physiological responses to environmental hypoxia exposure are largely unknown. A suite of potential hypoxia exposure biomarkers was evaluated in Atlantic croaker collected from hypoxic and normoxic regions in the northern Gulf of Mexico (nGOM), and in croaker after laboratory exposure to hypoxia (DO: 1...
2017: PloS One
https://www.readbyqxmd.com/read/28863191/anti-cancer-stem-cell-activity-of-a-sesquiterpene-lactone-isolated-from-ambrosia-arborescens-and-of-a-synthetic-derivative
#5
Wendy Soria Sotillo, Rodrigo Villagomez, Sandra Smiljanic, Xiaoli Huang, Atena Malakpour, Sebastian Kempengren, Gloria Rodrigo, Giovanna Almanza, Olov Sterner, Stina Oredsson
New regimens are constantly being pursued in cancer treatment, especially in the context of treatment-resistant cancer stem cells (CSCs) that are assumed to be involved in cancer recurrence. Here, we investigated the anti-cancer activity of sesquiterpene lactones (SLs) isolated from Ambrosia arborescens and of synthetic derivatives in breast cancer cell lines, with a specific focus on activity against CSCs. The breast cancer cell lines MCF-7, JIMT-1, and HCC1937 and the normal-like breast epithelial cell line MCF-10A were treated with the SLs damsin and coronopilin, isolated from A...
2017: PloS One
https://www.readbyqxmd.com/read/28836366/lipoteichoic-acid-upregulates-plasminogen-activator-inhibitor-1-expression-in-parapneumonic-effusions
#6
Kai-Ling Lee, Wei-Lin Chen, Ray-Jade Chen, Kevin S Lai, Chi-Li Chung
BACKGROUND AND OBJECTIVE: Parapneumonic effusion (PPE) is commonly caused by Gram-positive bacteria (GPB) and often presents with pleural loculation, which is characterized by overproduction of plasminogen activator inhibitor (PAI)-1. Lipoteichoic acid (LTA), a surface adhesion molecule of GPB, binds to the pleural mesothelium and triggers inflammation. However, the effects of LTA on PAI-1 expression in PPE and underlying mechanisms remain unclear. METHODS: Thirty consecutive patients with PPE were enrolled, including uncomplicated culture negative (CN, n = 11), Gram-negative bacteria (GNB, n = 7) and GPB (n = 12) groups stratified by pleural fluid characteristics and bacteriology, and the effusion PAI-1 levels were measured...
August 23, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28832635/expression-of-the-angiogenic-mediator-angiopoietin-like-4-in-the-eyes-of-patients-with-proliferative-sickle-retinopathy
#7
Kathleen Jee, Murilo Rodrigues, Fabiana Kashiwabuchi, Brooks P Applewhite, Ian Han, Gerard Lutty, Morton F Goldberg, Gregg L Semenza, Silvia Montaner, Akrit Sodhi
The recent success of therapies directly targeting the angiogenic mediator, vascular endothelial growth factor (VEGF), for the treatment of proliferative diabetic retinopathy has encouraged clinicians to extend the use of anti-VEGF therapies for the treatment of another ischemic retinal vascular disease, proliferative sickle cell retinopathy (PSR), the most common cause of irreversible blindness in patients with sickle cell disease. However, results from case reports evaluating anti-VEGF therapies for PSR have been mixed...
2017: PloS One
https://www.readbyqxmd.com/read/28832134/transcriptomic-response-of-arabidopsis-thaliana-exposed-to-cuo-nanoparticles-bulk-material-and-ionic-copper
#8
Premysl Landa, Pavel Dytrych, Sylva Prerostova, Sarka Petrova, Radomira Vankova, Tomas Vanek
Engineered nanoparticles (ENPs) exhibit unique properties advantageous in a number of applications, but they also represent potential health and environmental risks. In this study, we investigated the phytotoxic mechanism of CuO ENPs using transcriptomic analysis and compared this response with the response to CuO bulk particles and ionic Cu(2+). Ionic Cu(2+) at the concentration of 0.16 mg L(-1) changed transcription of 2692 genes (p value of <0.001, fold change of ≥2) after 7 days of exposure, whereas CuO ENPs and bulk particles (both in the concentration of 10 mg L(-1)) altered the expression of 922 and 482 genes in Arabidopsis thaliana roots, respectively...
September 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28830217/decreased-glucagon-like-peptide-1-receptor-expression-in-endothelial-and-smooth-muscle-cells-in-diabetic-db-db-mice-tcf7l2-is-a-possible-regulator-of-the-vascular-glucagon-like-peptide-1-receptor
#9
Tomohiko Kimura, Atsushi Obata, Masashi Shimoda, Seizo Okauchi, Hidenori Hirukawa, Kenji Kohara, Tomoe Kinoshita, Yuka Nogami, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
AIMS: Incretin signalling is known to prevent the development of arteriosclerosis by relaxation response in endothelial cells via the glucagon-like peptide 1 receptor. It remains unclear, however, whether vascular glucagon-like peptide 1 receptor expression is altered under some conditions. The aim of this study is to examine whether vascular glucagon-like peptide 1 receptor expression is altered by diabetic state as reported in pancreatic β-cells. METHODS: We used 18-week-old male diabetic db/db mice and control db/m mice...
August 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28814270/transcriptional-analysis-of-abdominal-fat-in-chickens-divergently-selected-on-bodyweight-at-two-ages-reveals-novel-mechanisms-controlling-adiposity-validating-visceral-adipose-tissue-as-a-dynamic-endocrine-and-metabolic-organ
#10
C W Resnyk, W Carré, X Wang, T E Porter, J Simon, E Le Bihan-Duval, M J Duclos, S E Aggrey, L A Cogburn
BACKGROUND: Decades of intensive genetic selection in the domestic chicken (Gallus gallus domesticus) have enabled the remarkable rapid growth of today's broiler (meat-type) chickens. However, this enhanced growth rate was accompanied by several unfavorable traits (i.e., increased visceral fatness, leg weakness, and disorders of metabolism and reproduction). The present descriptive analysis of the abdominal fat transcriptome aimed to identify functional genes and biological pathways that likely contribute to an extreme difference in visceral fatness of divergently selected broiler chickens...
August 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28813482/cysteine-rich-protein-2-accelerates-actin-filament-cluster-formation
#11
Takanori Kihara, Yasunobu Sugimoto, Satoko Shinohara, Shunpei Takaoka, Jun Miyake
Filamentous actin (F-actin) forms many types of structures and dynamically regulates cell morphology and movement, and plays a mechanosensory role for extracellular stimuli. In this study, we determined that the smooth muscle-related transcription factor, cysteine-rich protein 2 (CRP2), regulates the supramolecular networks of F-actin. The structures of CRP2 and F-actin in solution were analyzed by small-angle X-ray solution scattering (SAXS). The general shape of CRP2 was partially unfolded and relatively ellipsoidal in structure, and the apparent cross sectional radius of gyration (Rc) was about 15...
2017: PloS One
https://www.readbyqxmd.com/read/28801292/-oxidized-low-density-lipoprotein-modulates-differentiation-of-murine-memory-cd8-t-cell-subpopulations
#12
Hua Zheng, Ze-Hang Lin, Yan-Mei Zhang, Chen-Fei Zhou, Xuan Liu, Sha Wu
OBJECTIVE: To investigate effect of oxidized low-density lipoprotein (ox-LDL) on memory CD8(+) T cell subpopulation differentiation in mice with autoimmune diabetes. METHODS: Cultured splenic CD8(+) T cells from pre-diabetic NOD mice isolated with magnetic beads were treated with 30 µg/mL ox-LDL and 10 U/mL interleukin-2 (IL-2) for 24 h and the control cells were treated with IL-2 only. Flow cytometry was used to determine the percentage of splenic CD8(+)IFN-γ(+) T cells, expressions of CD8, CD44 and CD62L on the T cells, and the activation of T cell factor-1 (TCF-1) and STAT-3...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28795454/the-transcription-factor-7-like-2-peroxisome-proliferator-activated-receptor-gamma-coactivator-1-alpha-axis-connects-mitochondrial-biogenesis-and-metabolic-shift-with-stem-cell-commitment-to-hepatic-differentiation
#13
Anaïs Wanet, Marino Caruso, Jean-Baka Domelevo Entfellner, Mehdi Najar, Antoine Fattaccioli, Catherine Demazy, Jonathan Evraerts, Hoda El-Kehdy, Guillaume Pourcher, Etienne Sokal, Thierry Arnould, Nicki Tiffin, Mustapha Najimi, Patricia Renard
Increasing evidence supports that modifications in the mitochondrial content, oxidative phosphorylation (OXPHOS) activity, and cell metabolism influence the fate of stem cells. However, the regulators involved in the crosstalk between mitochondria and stem cell fate remain poorly characterized. Here, we identified a transcriptional regulatory axis, composed of transcription factor 7-like 2 (TCF7L2) (a downstream effector of the Wnt/β-catenin pathway, repressed during differentiation) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) (the master regulator of mitochondrial biogenesis, induced during differentiation), coupling the loss of pluripotency and early commitment to differentiation, to the initiation of mitochondrial biogenesis and metabolic shift toward OXPHOS...
August 10, 2017: Stem Cells
https://www.readbyqxmd.com/read/28794035/crystal-structure-of-the-dna-binding-domain-of-human-herpesvirus-6a-immediate-early-protein-2
#14
Mitsuhiro Nishimura, Junjie Wang, Aika Wakata, Kento Sakamoto, Yasuko Mori
Immediate early proteins of human herpesvirus 6A (HHV-6A) are expressed at the outset of lytic infection, and thereby regulate viral gene expression. Immediate early protein 2 (IE2) of HHV-6A is a trans-activator that drives a variety of promoters. The C-terminal region of HHV-6A IE2 is shared among IE2 homologs in beta-herpesviruses, and is involved in dimerization, DNA binding, and transcription factor binding. In this study, the structure of the C-terminal domain (IE2-CTD) was determined by X-ray crystallography at a resolution of 2...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28791367/molecular-mechanisms-of-breast-cancer-metastasis-by-gene-expression-profile-analysis
#15
Tianying Zheng, Aijun Wang, Dongyan Hu, Yonggang Wang
Metastasis is the main cause of breast cancer‑related mortalities. The present study aimed to uncover the relevant molecular mechanisms of breast cancer metastasis and to explore potential biomarkers that may be used for prognosis. Expression profile microarray data GSE8977, which contained 22 stroma samples (15 were from normal breast and 7 were from invasive ductal carcinoma tumor samples), were obtained from the Gene Expression Omnibus database. Following data preprocessing, differentially expressed genes (DEGs) were selected based on analyses conducted using the linear models for microarray analysis package from R and Bioconductor software...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28783759/senescence-as-a-novel-mechanism-involved-in-%C3%AE-adrenergic-receptor-mediated-cardiac-hypertrophy
#16
Rongrong Sun, Baoling Zhu, Kai Xiong, Yan Sun, Dandan Shi, Li Chen, Youyi Zhang, Zijian Li, Lixiang Xue
Pathological cardiac hypertrophy used to be elucidated by biomechanical, stretch-sensitive or neurohumoral mechanisms. However, a series of hints have indicated that hypertrophy process simulates senescence program. However, further evidence need to be pursued. To verify this hypothesis and examine whether cardiac senescence is a novel mechanism of hypertrophy induced by isoproterenol, 2-month-old male Sprague Dawley rats were subjected to isoproterenol infusion (0.25mg/kg/day) for 7 days by subcutaneous injection)...
2017: PloS One
https://www.readbyqxmd.com/read/28782620/anti-inflammatory-effect-of-cortex-eucommiae-via-modulation-of-the-toll-like-receptor-4-pathway-in-lipopolysaccharide-stimulated-raw-264-7-macrophages
#17
Wonil Koh, Joon-Shik Shin, Jinho Lee, In-Hee Lee, Sang Kook Lee, In-Hyuk Ha, Hwa-Jin Chung
ETHNOPHARMOCOLOGICAL RELEVANCE: Cortex Eucommiae (CE), the bark of Eucommia ulmoides Oliv., has been traditionally used for its kidney-tonifying and bone- and tendon-enhancing properties in Korea, China, and Japan. CE has been historically prescribed for inflammatory conditions such as arthritis of the knee and ankle. AIM OF THE STUDY: Although CE has recently been shown to suppress inflammation in scientific studies, whether this effect involves modulation of the toll-like receptor 4 (TLR-4) pathway is currently unknown...
August 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28747866/polysaccharide-from-wheat-bran-induces-cytokine-expression-via-the-toll-like-receptor-4-mediated-p38-mapk-signaling-pathway-and-prevents-cyclophosphamide-induced-immunosuppression-in-mice
#18
Ting Shen, Gongcheng Wang, Long You, Liang Zhang, Haiwei Ren, Weicheng Hu, Qian Qiang, Xinfeng Wang, Lilian Ji, Zhengzhong Gu, Xiangxiang Zhao
Wheat bran-derived polysaccharides have attracted particular attention due to their immunomodulatory effects. However, the molecular mechanisms underlying their functions are poorly understood. The current study was designed to examine the effect of wheat bran polysaccharide (WBP) on RAW 264.7 cells and the underlying signaling pathways, which have not been explored. In addition, we also investigated the immuno-enhancement effects of WBP on cyclophosphamide (CTX)-induced immunosuppression in mice. WBP significantly increased the concentrations of intracellular nitric oxide (NO) and cytokines such as prostaglandin E2 (PGE2) and tumor necrosis factor-α (TNF-α) in RAW 264...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28731172/comparison-of-the-neuronal-differentiation-abilities-of-bone-marrow%C3%A2-derived-and-adipose-tissue%C3%A2-derived-mesenchymal-stem-cells
#19
Yani Zheng, Chao Huang, Fang Liu, Haiyan Lin, Xiangqun Yang, Zhiying Zhang
Bone marrow‑derived mesenchymal stem cells (BMSCs) and adipose tissue‑derived mesenchymal stem cells (ADSCs) are able to differentiate into neuron‑like cells when exposed to small molecule compounds, however the specific differences in their neuronal differentiation abilities remain to be fully elucidated. The present study aimed to compare the neuronal differentiation abilities of BMSCs and ADSCs. BMSCs and ADSCs from the same Sprague Dawley rats were isolated and cultured for use. The proliferation capacity was revealed using a cell counting method...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28699988/type-2-diabetes-associated-genetic-variants-of-fto-lepr-pparg-and-tcf7l2-in-gestational-diabetes-in-a-brazilian-population
#20
Mauren Isfer Anghebem-Oliveira, Bruna Rodrigues Martins, Dayane Alberton, Edneia Amancio de Souza Ramos, Geraldo Picheth, Fabiane Gomes de Moraes Rego
Objective: Gestational diabetes mellitus (GDM) is a metabolic disorder that shares pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to investigate the association of the polymorphisms fat mass and obesity-associated (FTO) rs1421085, leptin receptor (LEPR) rs1137100, rs1137101, peroxisome proliferator-activated receptor gamma (PPARg) rs1801282, and transcription factor 7-like 2 (TCF7L2) rs7901695 with GDM. Subjects and methods: 252 unrelated Euro-Brazilian pregnant women were classified into two groups according to the 2015 criteria of the American and Brazilian Diabetes Association: healthy pregnant women (n = 125) and pregnant women with GDM (n = 127), matched by age...
May 2017: Archives of Endocrinology and Metabolism
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