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https://www.readbyqxmd.com/read/27326392/the-tosca-registry-an-ongoing-observational-multicenter-registry-for-chronic-heart-failure
#1
M Arcopinto, A Salzano, F Ferrara, E Bobbio, A M Marra, R Abete, F Stagnaro, R Polizzi, F Giallauria, M Illario, E Menditto, C Vigorito, E Bossone, A Cittadini
The ageing of the population in western countries, the continuous increase of the prevalence of chronic diseases, the frequent coexistence of several morbid conditions (comorbidity) requires health professionals and Institutions to face difficult challenges, including increasing costs, need for more effective and sustainable therapies, and organizational issues. The European Innovation Partnership on Active and Healthy Ageing aims at enabling European citizens to lead healthy, active and independent lives while ageing...
May 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27126440/factors-associated-with-frailty-in-primary-care-a-prospective-cohort-study
#2
Ana Diez-Ruiz, Antonio Bueno-Errandonea, Jazmina Nuñez-Barrio, Inmaculada Sanchez-Martín, Kalliopi Vrotsou, Itziar Vergara
BACKGROUND: Frailty can be defined as a progressive loss of reserve and adaptive capacity associated with an overall deterioration in health that can result in disability, loss of independence, hospitalisation, extensive use of healthcare resources, admission to long-term care and death. Nevertheless, despite widespread use of the term, there is no agreement on the definition of frailty or an instrument to identify it in a straightforward way. The purpose of the current study was to explore which factors are associated with frailty-related adverse outcomes in elderly individuals and to propose a suitable tool for identifying such individuals, particularly in primary care settings...
April 28, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/26970837/-prevalence-of-potentially-inappropriate-drug-prescription-in-the-elderly
#3
A Fajreldines, J Insua, E Schnitzler
INTRODUCTION: One of the causes of preventable adverse drug events (ADES) in older patients constitutes inappropriate prescription of drugs (PIM). The PIM is where risks exceed the clinical benefit. Several instruments can be use to measure this problem, the most used are: a) Beers criteria; b) Screening tool to Older People Potentially inappropriate Prescription (STOPP); c) Screening tool to Alert Doctors to Right Appropriate indicated Treatments (START); d) The Medication Appropriateness Index (MAI)...
September 2016: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/24168151/hematopoietic-growth-factors-support-in-the-elderly-cancer-patients-treated-with-antiblastic-chemotherapy
#4
REVIEW
Maurizio Rupolo, Arben Lleshi, Bruno Cacopardo, Mariagrazia Michieli, Massimiliano Berretta
The 60% of tumors affected patients >65years of age and the future previsions are considering an amount of 70% after 2030. Elderly Patients presents multiple comorbidity, polipharmacy, and disability. Geriatric assessment helps physicians to take the best therapeutic decisions. Clinical conditions influence efficacy and tolerability of chemotherapy. Prophylactic use of G-CSF after chemotherapy lowers the rate and length of severe neutropenia , and decreases the episodes of febrile neutropenia. Anemia is a hematologic condition associated with ageing , but is frequently associated to concomitant chronic disease...
November 2013: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/24102275/hematopoietic-growth-factor-support-in-the-elderly-treated-with-chemotherapy
#5
M Rupolo, M Berretta
The 60% of tumors affected patients >65years of age and the future previsions are considering an amount of 70% after 2030. Elderly Patients presents multiple comorbidity, polipharmacy, and disability. Geriatric assessment helps physicians to take the best therapeutic decisions. Clinical conditions influence efficacy and tolerability of chemotherapy. Prophylactic use of G-CSF after chemotherapy lowers the rate and length of severe neutropenia , and decreases the episodes of febrile neutropenia. Anemia is a hematologic condition associated with ageing , but is frequently associated to concomitant chronic disease...
October 9, 2013: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/23250256/-factors-associated-to-the-use-of-psychotropic-drugs-by-community-dwelling-elderly-in-s%C3%A3-o-paulo-city
#6
Aparecida Santos Noia, Silvia Regina Secoli, Yeda Aparecida de Oliveira Duarte, Maria Lúcia Lebrão, Nicolina Silvana Romano Lieber
The objectives of study were to identify the prevalence and factors associated to the use of psychotropic drugs among elderly people in São Paulo city. It is a cross-sectional study. Data were used from the SABE survey (for Health, Well-being and Ageing). The sample was constituted of 1.115 elderly people, aging 65 and over, which were interviewed by standard method. In the data analysis, it was used univariate and multiple logistic regression, stepwise forward and level of significance of 5%. The prevalence of the use of psychotropic drugs of 12,2% and the factors associated were female gender (OR=3,04 IC95%= 1,76-5,23) and polypharmacy (OR=4,91 IC95%=2,74-8,79)...
October 2012: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/21936175/-medication-adherence-of-elderly-in-porto-alegre-rs
#7
Cristiane Hoffmeister Rocha, Ana Paula Sueiro de Oliveira, Caroline Ferreira, Fabiana Tôrres Faggiani, Guilherme Schroeter, Antônio Carlos Araújo de Souza, Geraldo Attilio DeCarli, Fernanda Bueno Morrone, Maria Cristina Werlang
Polipharmacy and medication non-adherence are problems faced frequently in the treatment of elderly patients. An exploratory cross-sectional study and quantitative approach were conducted to assess the frequency of treatment-adherence in elderly and how polipharmacy can affect adherence. Four hundred and sixty six elderly answered a questionnaire in Porto Alegre, RS in individual interviews. The adherence frequency found was 173 (37.1%) and was higher among those, who use less medication. These results indicate the need for implementing educational programs for the elderly in order to help them to follow their drug therapy...
April 2008: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/21308234/-prevalence-and-features-of-falls-of-institutionalized-elders
#8
Denise Cristina de Oliveira Ferreira, Aparecida Yoshie Yoshitome
This retrospective study seeks to check the prevalence of falls in older people from a long-term care institution for elderly people, in São Paulo, to describe the fallers and the events. We analyzed 121 medical records and 87 fall reports, between August 2006 and August 2007. There were 114 falls suffered by 45 ancians, a prevalence of 37,2%. The majority of fallers are women, average age 83,75 years. We found recurrent falls, various diagnoses and polipharmacy. The majority occurred in own height, in their bedroom, producing mainly hematomas...
November 2010: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/20394217/-the-relationship-between-polipharmacy-chronic-complications-and-depression-in-individuals-with-type-2-diabetes-mellitus
#9
Alexandra Bulgarelli do Nascimento, Eliane Corrêa Chaves, Sônia Aurora Alves Grossi, Simão Augusto Lottenberg
The objectives of this study were: to characterize the polipharmacy in subjects with type 2 diabetes mellitus (DM2) and to verify the correlation between polipharmacy and number of medications for DM2 complications with depression indicators (Beck Depression inventory (BDI) and urinary cortisol (CORT) levels). A sample composed of 40 patients with DM2 from the Diabetes League of HCFM-USP was analyzed for depression indicators (CORT and BDI) in addition to evaluation for polipharmacy and number of DM2 complications...
March 2010: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/18227473/treatment-of-type-2-diabetes-with-combined-therapy-what-are-the-pros-and-cons
#10
REVIEW
Massimo Massi-Benedetti, Marco Orsini-Federici
Type 2 diabetes is a progressive syndrome that evolves toward complete insulin deficiency during the patient's life. A stepwise approach for its treatment should be tailored according to the natural course of the disease, including adding insulin when hypoglycemic oral agent failure occurs. Treatment with insulin alone should eventually be considered in a relevant number of cases. Experience has shown the protective effects of insulin on beta-cell survival and function, resulting in more stable metabolic control...
February 2008: Diabetes Care
https://www.readbyqxmd.com/read/18157433/-refractory-schizophrenia
#11
REVIEW
Helio Elkis, Herbert Y Meltzer
OBJECTIVE: The aim of the present paper is to review the various aspects of refractory schizophrenia regarding issues such as definitions, clinical aspects, psychobiological correlates, pharmacological and non-pharmacological treatment options and predictors of treatment response. METHOD: Medline search as well as articles of the authors. RESULTS AND CONCLUSIONS: Refractory schizophrenia affects at least one third of patients with schizophrenia and the best evidence shows that is monotherapy with clozapine remains the mainstay for the treatment of such condition...
October 2007: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/15529221/-polipharmacy-in-the-antipsychotic-prescribing-in-practices-psychiatric-out-patient-clinic
#12
G Florez Menéndez, M Blanco Ramos, I Gómez-Reino Rodríguez, P Gayoso Diz, J Bobes García
INTRODUCTION: Due to the lack of scientific studies in the psychopharmacological treatment of psychosis, the references advise against the use of antipsychotic polypharmacy (AP). This study investigates the situation of this matter and its relationship with the introduction of atypical antipsychotics (AA) in our daily out-patient practice. METHODS: The study group included 160 patients, with ICD-10 diagnosis of non-affective psychosis and illness evolution of at least two years, whose ages ranged from 18 to 65 years, without mental retardation, who came to the out patient clinic at least once during the first semester of 2002 and, in order to make a comparison, at least one other time 9 to 12 months before...
November 2004: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/1205653/increasing-threat-to-man-as-a-result-of-frequently-uncontrolled-and-widespread-use-of-various-drugs
#13
J Venulet
Consumption of drugs is steadily increasing. The reasons for this could be the diminished threshold level of acceptable sufferings, increased expectations about health, the psychological effects of a medical prescription, publicity, consumer society attitude in respect to drugs and polipharmacy. Overexposure to drugs increases the risk of precipitating drug adverse reactions. This could be avoided in many cases by non-administration of an unnecessary drug. The frequency and consequences of drug adverse reactions are considerable, and WHO plays an import role in collecting data and facilitating the exchange of informations in that area...
December 1975: International Journal of Clinical Pharmacology and Biopharmacy
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