keyword
https://read.qxmd.com/read/33142318/the-circadian-clock-shift-work-and-tissue-specific-insulin-resistance
#1
REVIEW
Johanneke E Oosterman, Suzan Wopereis, Andries Kalsbeek
Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of obesity and T2D is significantly higher in shift workers compared to people working regular hours. An accepted hypothesis is that the increased risk for metabolic health problems arises from aberrantly timed eating behavior, that is, eating out of synchrony with the biological clock. The biological clock is part of the internal circadian timing system, which controls not only the sleep/wake and feeding/fasting cycle, but also many metabolic processes in the body, including the timing of our eating behavior, and processes involved in glucose homeostasis...
December 1, 2020: Endocrinology
https://read.qxmd.com/read/33142302/-the-disease-management-experience-of-patients-with-asthma-grounded-theory-approach
#2
JOURNAL ARTICLE
Bohye Kim, Oksoo Kim
PURPOSE: The aim of this study was to develop a situation-specific theory to explain the disease management experience of patients with asthma. METHODS: Twenty participants with asthma were selected using the theoretical sampling method. The data were acquired through in-depth interviews conducted from June to October 2018 and analyzed using the grounded theory approach of Strauss and Corbin. RESULTS: In total, 69 concepts, 30 subcategories, and 13 categories were generated to explain the disease management experience of patients with asthma...
October 2020: Journal of Korean Academy of Nursing
https://read.qxmd.com/read/33142298/-predictors-of-blood-and-body-fluid-exposure-and-mediating-effects-of-infection-prevention-behavior-in-shift-working-nurses-application-of-analysis-method-for-zero-inflated-count-data
#3
JOURNAL ARTICLE
Jae Geum Ryu, Smi Choi-Kwon
PURPOSE: This study aimed to identify the predictors of blood and body fluid exposure (BBFE) in multifaceted individual (sleep disturbance and fatigue), occupational (occupational stress), and organizational (hospital safety climate) factors, as well as infection prevention behavior. We also aimed to test the mediating effect of infection prevention behavior in relation to multifaceted factors and the frequency of BBFE. METHODS: This study was based on a secondary data analysis, using data of 246 nurses from the Shift Work Nurses' Health and Turnover study...
October 2020: Journal of Korean Academy of Nursing
https://read.qxmd.com/read/33142004/the-efficacy-of-internet-based-cognitive-behavioural-therapy-for-social-anxiety-disorder-a-systematic-review-and-meta-analysis
#4
REVIEW
Shangyu Guo, Wenrui Deng, Hongtao Wang, Jiayuan Liu, Xiaoyu Liu, Xinxin Yang, Cengceng He, Qiqi Zhang, Boya Liu, Xinghua Dong, Zifan Yang, Ziqi Li, Xiaoming Li
Social anxiety disorder (SAD) is one of the most common lifelong anxiety disorders. Although cognitive behavioural therapy (CBT) has proven to be effective in treating people with SAD, it may not be available for a considerable proportion of patients. Internet-based CBT (ICBT) is more accessible than face-to-face treatment. This meta-analysis evaluated the efficacy of ICBT in patients with SAD. We searched five databases, PubMed, Cochrane Central Register of Controlled Trials, Health Management Information Consortium, Ovid MEDLINE and EMBASE, and identified 20 eligible randomized controlled trials published from inception to 25 July 2020, with the outcome data from 1,743 participants...
May 2021: Clinical Psychology & Psychotherapy
https://read.qxmd.com/read/33141103/efficacy-of-an-online-physical-activity-intervention-coordinated-with-routine-clinical-care-protocol-for-a-pilot-randomized-controlled-trial
#5
JOURNAL ARTICLE
Bonny Rockette-Wagner, Gary S Fischer, Andrea M Kriska, Molly B Conroy, David Dunstan, Caroline Roumpz, Kathleen M McTigue
BACKGROUND: Most adults are not achieving recommended levels of physical activity (150 minutes/week, moderate-to-vigorous intensity). Inadequate activity levels are associated with numerous poor health outcomes, and clinical recommendations endorse physical activity in the front-line treatment of obesity, diabetes, dyslipidemia, and hypertension. A framework for physical activity prescription and referral has been developed, but has not been widely implemented. This may be due, in part, to the lack of feasible and effective physical activity intervention programs designed to coordinate with clinical care delivery...
November 3, 2020: JMIR Research Protocols
https://read.qxmd.com/read/33141096/computer-tailored-decision-support-tool-for-lung-cancer-screening-community-based-pilot-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Lisa Carter-Harris, Robert Skipworth Comer, James E Slaven Ii, Patrick O Monahan, Emilee Vode, Nasser H Hanna, DuyKhanh Pham Ceppa, Susan M Rawl
BACKGROUND: Lung cancer screening is a US Preventive Services Task Force Grade B recommendation that has been shown to decrease lung cancer-related mortality by approximately 20%. However, making the decision to screen, or not, for lung cancer is a complex decision because there are potential risks (eg, false positive results, overdiagnosis). Shared decision making was incorporated into the lung cancer screening guideline and, for the first time, is a requirement for reimbursement of a cancer screening test from Medicare...
November 3, 2020: Journal of Medical Internet Research
https://read.qxmd.com/read/33141091/a-behavioral-change-smartphone-app-and-program-todo-cr-to-decrease-sedentary-behavior-in-cardiac-rehabilitation-participants-prospective-feasibility-cohort-study
#7
JOURNAL ARTICLE
Nicole Freene, Sander van Berlo, Margaret McManus, Tarryn Mair, Rachel Davey
BACKGROUND: Cardiac rehabilitation participants are encouraged to meet physical activity guidelines to reduce the risk of repeat cardiac events. However, previous studies have found that physical activity levels are low and sedentary behavior is high, both during and after cardiac rehabilitation. There is potential for smartphone apps to be effective in reducing sedentary behavior, although among the few studies that have investigated smartphone apps in cardiac rehabilitation, none targeted sedentary behavior...
November 3, 2020: JMIR Formative Research
https://read.qxmd.com/read/33141048/progression-of-human-subjective-perceptions-during-euhydration-mild-dehydration-and-drinking
#8
JOURNAL ARTICLE
Lawrence E Armstrong, Gabrielle E W Giersch, Abigail T Colburn, Virgilio Lopez, Yasuki Sekiguchi, Colleen X Muñoz, Elaine C Lee
Thirst motivates consumption of water necessary for optimal health and cognitive-physiological functions. Other than thirst, little is known about coexisting perceptions and moods that provide information to the brain and participate in body water homeostasis. The purpose of this investigation was to observe perceptions, somatic sensations, and moods during controlled changes of hydration status. During routine daily activities interspersed with laboratory visits, 18 healthy young men (age, 23±3 y; body mass, 80...
October 23, 2020: Physiology & Behavior
https://read.qxmd.com/read/33140717/the-role-of-explanatory-models-of-breast-cancer-in-breast-cancer-prevention-behaviors-among-arab-israeli-physicians-and-laywomen
#9
JOURNAL ARTICLE
Michal Soffer, Miri Cohen, Faisal Azaiza
BACKGROUND: 'Explanatory Models' (EMs) are frameworks through which individuals and groups understand diseases, are influenced by cultural and religious perceptions of health and illness, and influence both physicians and patients' behaviors. AIMS: To examine the role of EMs of illness (cancer-related perceptions) in physicians' and laywomen's behaviors (decision to recommend undergoing regular mammography, adhering to mammography) in the context of a traditional-religious society, that is, the Arab society in Israel...
November 3, 2020: Primary Health Care Research & Development
https://read.qxmd.com/read/33140690/dft-and-docking-studies-of-designed-conjugates-of-noscapines-repurposing-drugs-promising-inhibitors-of-main-protease-of-sars-cov-2-and-falcipan-2
#10
JOURNAL ARTICLE
Ajay Kumar, Durgesh Kumar, Ravinder Kumar, Prashant Singh, Ramesh Chandra, Kamlesh Kumari
First case of the present epidemic, coronavirus disease (COVID-19) is reported in the Wuhan, a city of the China and all the countries throughout the world are being affected. COVID-19 is named by World Health Organization and it stands for coronavirus disease-19. As on 27th October, 2020, 73,776,588 people around the world are infected. It is also known as SARS-CoV-2 infection. Till date, there is no promising drug or vaccine available in market to cure from this lethal infection. As the literature reported that noscapine a promising candidate to cure from malaria as well reported to be cough suppressant and anti-cancerous...
November 3, 2020: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/33140687/tree-based-machine-learning-to-identify-and-understand-major-determinants-for-stroke-at-the-neighborhood-level
#11
JOURNAL ARTICLE
Liangyuan Hu, Bian Liu, Jiayi Ji, Yan Li
Background Stroke is a major cardiovascular disease that causes significant health and economic burden in the United States. Neighborhood community-based interventions have been shown to be both effective and cost-effective in preventing cardiovascular disease. There is a dearth of robust studies identifying the key determinants of cardiovascular disease and the underlying effect mechanisms at the neighborhood level. We aim to contribute to the evidence base for neighborhood cardiovascular health research. Methods and Results We created a new neighborhood health data set at the census tract level by integrating 4 types of potential predictors, including unhealthy behaviors, prevention measures, sociodemographic factors, and environmental measures from multiple data sources...
November 3, 2020: Journal of the American Heart Association
https://read.qxmd.com/read/33140549/nutritional-interventions-for-promoting-stress-resilience-recent-progress-using-psychosocial-stress-models-of-rodents
#12
REVIEW
Atsushi Toyoda
Prevention of stress-induced adverse effects is important for animals and humans to maintain their quality of life (QOL). Stress decreases the productivity of farm animals and induces abnormal behaviors, which is one of the major problems in animal welfare. In humans, stress increases the risk of mental illness which adversely impacts QOL. Stress is, thus, a common health problem for both animals and humans, and stress prevention and promotion of stress resilience could improve animal and human health and QOL...
January 2020: Animal Science Journal
https://read.qxmd.com/read/33140518/psychological-differences-between-toilet-trained-and-non-toilet-trained-4-year-old-children
#13
JOURNAL ARTICLE
Michael I Axelrod, Ray J Larsen, Keith Jorgensen, Bobbie Stratman
OBJECTIVE: Late to complete toilet training has been associated with many psychological factors including behavior and mood problems. Unfortunately, the majority of the research is specific to children with elimination disorders or children identified as incontinent after the age of 7 years. The current study addressed gaps in the literature by comparing the psychological functioning of children not toilet trained by their 4-year-old well child care visit with their toilet trained peers...
November 2, 2020: Journal for Specialists in Pediatric Nursing: JSPN
https://read.qxmd.com/read/33140489/psychiatric-hospital-admission-and-later-crime-mental-health-and-labor-market-outcomes
#14
JOURNAL ARTICLE
Rasmus Landersø, Peter Fallesen
Most OECD countries have downsized treatment capacity at psychiatric hospitals substantially. We investigate consequences of these reductions by studying how the decision whether to admit individuals in mental distress to a psychiatric hospital affects their subsequent crime, treatment trajectories, and labor market outcomes. To circumvent nonrandom selection into admission, we use a proxy of occupancy rates prior to a patient's first contact with a psychiatric hospital as an instrument. We find that admissions reduce criminal behavior, likely due to incapacitation, and predominantly for males and those with a criminal record...
January 2021: Health Economics
https://read.qxmd.com/read/33140106/evidence-for-cancer-literacy-knowledge-retention-among-kentucky-middle-and-high-school-students-after-a-brief-educational-intervention
#15
JOURNAL ARTICLE
Lauren Hudson, Chris Prichard, L Todd Weiss, Nathan L Vanderford
OBJECTIVES: Although cancer is seen in every state in the United States, it does not affect every geographic area and population equally. Kentucky has the highest cancer incidence and mortality rates in the country, with an unusually high number of cases localized in its Appalachian region. Risk factors such as sun exposure, tobacco use, poor diet/exercise, poverty, and lack of access to healthcare centers contribute to this disparity. Because education levels in the area are low, cancer literacy (defined as how well a person can understand the advice of a healthcare professional and make appropriate lifestyle decisions) also is low...
November 2020: Southern Medical Journal
https://read.qxmd.com/read/33140009/the-national-endoscopy-database-ned-automated-performance-reports-to-improve-quality-outcomes-trial-apriqot-randomized-controlled-trial-design
#16
JOURNAL ARTICLE
Jamie Catlow, Linda Sharp, Adetayo Kasim, Liya Lu, Matthew Brookes, Tom Lee, Stephen McCarthy, Joanne Gray, Falko Sniehotta, Jill Deane, Matt Rutter
Background and study aims  Colonoscopists with low polyp detection have higher post colonoscopy colorectal cancer incidence and mortality rates. The United Kingdom's National Endoscopy Database (NED) automatically captures patient level data in real time and provides endoscopy key performance indicators (KPI) at a national, endoscopy center, and individual level. Using an electronic behavior change intervention, the primary objective of this study is to assess if automated feedback of endoscopist and endoscopy center-level optimal procedure-adjusted detection KPI (opadKPI) improves polyp detection performance...
November 2020: Endoscopy International Open
https://read.qxmd.com/read/33139605/role-of-artificial-intelligence-in-fighting-antimicrobial-resistance-in-pediatrics
#17
REVIEW
Umberto Fanelli, Marco Pappalardo, Vincenzo Chinè, Pierpacifico Gismondi, Cosimo Neglia, Alberto Argentiero, Adriana Calderaro, Andrea Prati, Susanna Esposito
Artificial intelligence (AI) is a field of science and engineering concerned with the computational understanding of what is commonly called intelligent behavior. AI is extremely useful in many human activities including medicine. The aim of our narrative review is to show the potential role of AI in fighting antimicrobial resistance in pediatric patients. We searched for PubMed articles published from April 2010 to April 2020 containing the keywords "artificial intelligence", "machine learning", "antimicrobial resistance", "antimicrobial stewardship", "pediatric", and "children", and we described the different strategies for the application of AI in these fields...
November 1, 2020: Antibiotics
https://read.qxmd.com/read/33139537/antibody-mediated-activation-of-the-fgfr1-klotho%C3%AE-complex-corrects-metabolic-dysfunction-and-alters-food-preference-in-obese-humans
#18
RANDOMIZED CONTROLLED TRIAL
Amos Baruch, Chin Wong, Leslie W Chinn, Anjali Vaze, Junichiro Sonoda, Thomas Gelzleichter, Shan Chen, Nicholas Lewin-Koh, Linda Morrow, Suresh Dheerendra, Richard Boismenu, Johnny Gutierrez, Eric Wakshull, Maria E Wilson, Puneet S Arora
Fibroblast growth factor 21 (FGF21) controls metabolic organ homeostasis and eating/drinking behavior via FGF receptor 1/Klothoβ (FGFR1/KLB) complexes expressed in adipocytes, pancreatic acinar cells, and the nervous system in mice. Chronic administration of recombinant FGF21 or engineered variants improves metabolic health in rodents, nonhuman primates, and humans; however, the rapid turnover of these molecules limits therapeutic utility. Here we show that the bispecific anti-FGFR1/KLB agonist antibody BFKB8488A induced marked weight loss in obese cynomolgus monkeys while elevating serum adiponectin and the adipose expression of FGFR1 target genes, demonstrating its action as an FGF21 mimetic...
November 17, 2020: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/33139508/historical-perspectives-unsilencing-suffering-promoting-maternal-mental-health-in-neonatal-intensive-care-units
#19
JOURNAL ARTICLE
Jessica X Ouyang, Jessica L W Mayer, Cynthia L Battle, Joanna E Chambers, Zeynep N Inanc Salih
Mothers of infants in the NICU suffer higher rates of psychological distress, anxiety, and depression compared with the general population. Often, their mental health concerns remain underidentified and undertreated, which can have deleterious effects on the offspring, both in short-term outcomes while in the NICU as well as long-term neurodevelopmental and behavioral outcomes. In this review, we present an overview of existing empirical evidence about how maternal mental health affects the health of infants, special considerations regarding the mental health needs of NICU mothers, and the findings about existing and developing interventions to address mental health concerns in this vulnerable population...
November 2020: NeoReviews
https://read.qxmd.com/read/33139455/kindergarten-readiness-later-health-and-social-costs
#20
MULTICENTER STUDY
Caroline Fitzpatrick, Elroy Boers, Linda S Pagani
OBJECTIVES: To estimate associations between kindergarten readiness and academic, psychological, and health risks by end of high school. METHODS: This study is based on 966 Canadian children. At age 5, trained examiners assessed child number knowledge and receptive vocabulary. Teachers reported kindergarten classroom engagement. At age 17, participants reported academic grades, school connectedness, anxiety sensitivity, substance abuse, physical activity involvement, and height and weight...
December 2020: Pediatrics
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