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https://www.readbyqxmd.com/read/28749373/dosimetric-evaluation-of-a-commercial-proton-spot-scanning-monte-carlo-dose-algorithm-comparisons-against-measurements-and-simulations
#1
Jatinder Saini, Dominic Maes, Alexander Egan, Stephen R Bowen, Sara St James, Martin Janson, Tony Wong, Charles Bloch
RaySearch Americas Inc. (NY) has introduced a commercial Monte Carlo dose algorithm (RS-MC) for routine clinical use in proton spot scanning. In this report, we provide a validation of this algorithm against phantom measurements and simulations in GATE/GEANT4 software package. We also compared the performance of RayStation analytical algorithm (RS-PBA) against the RS-MC algorithm. Methods: A beam model (G-MC) for spot scanning gantry at our proton center was implemented in the GATE software package. The model was validated against measurements in a water phantom and was used for benchmarking the RS-MC...
July 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28749130/fluorination-of-boron-doped-diamond-film-electrodes-for-minimization-of-perchlorate-formation
#2
Pralay Gayen, Brian P Chaplin
This research investigated the effects of surface fluorination on both rates of organic compound oxidation (phenol, terephthalic acid (TA)) and ClO4(-) formation at boron-doped diamond (BDD) film anodes at 22(o) C. Different fluorination methods (i.e., electrochemical oxidation with perfluorooctanoic acid (PFOA), radio frequency plasma, and silanization) were used to incorporate fluorinated moieties on the BDD surface, which was confirmed by X-ray photoelectron spectroscopy (XPS). The silanization method was found to be the most effective fluorination method using a 1H, 1H, 2H, 2H perfluorodecyltrichlorosilane (aliphatic silane) precursor to form a self assembled monolayer (SAM) on the oxygenated BDD surface...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748614/novel-activating-braf-fusion-identifies-a-recurrent-alternative-mechanism-for-erk-activation-in-pediatric-langerhans-cell-histiocytosis
#3
Sara Zarnegar, Benjamin H Durham, Pallavi Khattar, Neerav N Shukla, Ryma Benayed, Mario E Lacouture, Ehud Lavi, David C Lyden, Eli L Diamond, Ira J Dunkel, Omar Abdel-Wahab
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm characterized by constitutive activation of extracellular signal-regulated kinase (ERK). Genomic characterization has identified activating point mutations including mutually exclusive BRAFV600E and activating MAP2K1 mutations to be responsible for ERK activation in a majority of pediatric LCH patients. Here, we report the discovery of a novel BRAF kinase fusion, PACSIN2-BRAF, in a child with multisystem LCH. This is the second reported case of an activating BRAF kinase fusion and indicates a recurrent pathologic mechanism...
July 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28748311/advantages-of-melodic-over-rhythmic-movement-sonification-in-bimanual-motor-skill-learning
#4
J F Dyer, P Stapleton, M W M Rodger
An important question for skill acquisition is whether and how augmented feedback can be designed to improve the learning of complex skills. Auditory information triggered by learners' actions, movement sonification, can enhance learning of a complex bimanual coordination skill, specifically polyrhythmic bimanual shape tracing. However, it is not clear whether the coordination of polyrhythmic sequenced movements is enhanced by auditory-specified timing information alone or whether more complex sound mappings, such as melodic sonification, are necessary...
July 26, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28747731/dynamical-sensitivity-control-of-a-single-spin-quantum-sensor
#5
Andrii Lazariev, Silvia Arroyo-Camejo, Ganesh Rahane, Vinaya Kumar Kavatamane, Gopalakrishnan Balasubramanian
The Nitrogen-Vacancy (NV) defect in diamond is a unique quantum system that offers precision sensing of nanoscale physical quantities at room temperature beyond the current state-of-the-art. The benchmark parameters for nanoscale magnetometry applications are sensitivity, spectral resolution, and dynamic range. Under realistic conditions the NV sensors controlled by conventional sensing schemes suffer from limitations of these parameters. Here we experimentally show a new method called dynamical sensitivity control (DYSCO) that boost the benchmark parameters and thus extends the practical applicability of the NV spin for nanoscale sensing...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747508/mutations-in-the-e2-glycoprotein-and-the-3-untranslated-region-enhance-chikungunya-virus-virulence-in-mice
#6
David W Hawman, Kathryn S Carpentier, Julie M Fox, Nicholas A May, Wes Sanders, Stephanie A Montgomery, Nathaniel J Moorman, Michael S Diamond, Thomas E Morrison
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes debilitating musculoskeletal pain and inflammation and can persist for months to years after acute infection. Although studies in humans and experimentally-infected animals suggest that CHIKV infection persists in musculoskeletal tissues, the mechanisms for this remain poorly understood. To evaluate this further, we isolated CHIKV from the serum of persistently infected Rag1(-/-) mice at day 28. When inoculated into naïve WT mice, this persistently circulating CHIKV strain displayed a capacity for earlier dissemination and greater pathogenicity compared with the parental virus...
July 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28747045/molecular-dynamics-modeling-and-simulation-of-diamond-cutting-of-cerium
#7
Junjie Zhang, Haibing Zheng, Maobing Shuai, Yao Li, Yang Yang, Tao Sun
The coupling between structural phase transformations and dislocations induces challenges in understanding the deformation behavior of metallic cerium at the nanoscale. In the present work, we elucidate the underlying mechanism of cerium under ultra-precision diamond cutting by means of molecular dynamics modeling and simulations. The molecular dynamics model of diamond cutting of cerium is established by assigning empirical potentials to describe atomic interactions and evaluating properties of two face-centered cubic cerium phases...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28745578/cost-effectiveness-of-g5-mobile-continuous-glucose-monitoring-cgm-device-compared-with-self-monitoring-of-blood-glucose-smbg-alone-for-people-with-type-1-diabetes-from-the-canadian-societal-perspective
#8
Shraddha Chaugule, Claudia Graham
AIMS: To evaluate the cost-effectiveness of real-time continuous glucose monitoring (CGM) compared to self-monitoring of blood glucose (SMBG) alone in people with type 1 diabetes (T1DM) using multiple daily injections (MDI) from the Canadian societal perspective. METHODS: The IMS CORE Diabetes Model (v.9.0) was used to assess the long-term (50 years) cost-effectiveness of real-time CGM (G5 Mobile CGM System; Dexcom, Inc., San Diego, CA) compared with SMBG alone for a cohort of adults with poorly-controlled T1DM...
July 26, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28745457/discrimination-of-diamond-blackfan-anemia-from-parvovirus-b19-infection-by-rbc-glutathione
#9
Jun Noguchi, Hitoshi Kanno, Yuta Chiba, Etsuro Ito, Akira Ishiguro
No abstract text is available yet for this article.
July 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28743965/nanocrystalline-diamond-protects-zr-cladding-surface-against-oxygen-and-hydrogen-uptake-nuclear-fuel-durability-enhancement
#10
Jan Škarohlíd, Petr Ashcheulov, Radek Škoda, Andrew Taylor, Radim Čtvrtlík, Jan Tomáštík, František Fendrych, Jaromír Kopeček, Vladimír Cháb, Stanislav Cichoň, Petr Sajdl, Jan Macák, Peng Xu, Jonna M Partezana, Jan Lorinčík, Jana Prehradná, Martin Steinbrück, Irena Kratochvílová
In this work, we demonstrate and describe an effective method of protecting zirconium fuel cladding against oxygen and hydrogen uptake at both accident and working temperatures in water-cooled nuclear reactor environments. Zr alloy samples were coated with nanocrystalline diamond (NCD) layers of different thicknesses, grown in a microwave plasma chemical vapor deposition apparatus. In addition to showing that such an NCD layer prevents the Zr alloy from directly interacting with water, we show that carbon released from the NCD film enters the underlying Zr material and changes its properties, such that uptake of oxygen and hydrogen is significantly decreased...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743929/3d-semiconducting-nanostructures-via-inverse-lipid-cubic-phases
#11
M R Burton, C Lei, P A Staniec, N J Terrill, A M Squires, N M White, Iris S Nandhakumar
Well-ordered and highly interconnected 3D semiconducting nanostructures of bismuth sulphide were prepared from inverse cubic lipid mesophases. This route offers significant advantages in terms of mild conditions, ease of use and electrode architecture over other routes to nanomaterials synthesis for device applications. The resulting 3D bicontinous nanowire network films exhibited a single diamond topology of symmetry Fd3m (Q227) which was verified by Small angle X-ray scattering (SAXS) and Transmission electron microscopy (TEM) and holds great promise for potential applications in optoelectronics, photovoltaics and thermoelectrics...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743902/structure-of-spin-excitations-in-heavily-electron-doped-li0-8fe0-2odfese-superconductors
#12
Bingying Pan, Yao Shen, Die Hu, Yu Feng, J T Park, A D Christianson, Qisi Wang, Yiqing Hao, Hongliang Wo, Zhiping Yin, T A Maier, Jun Zhao
Heavily electron-doped iron-selenide high-transition-temperature (high-T c) superconductors, which have no hole Fermi pockets, but have a notably high T c, have challenged the prevailing s ± pairing scenario originally proposed for iron pnictides containing both electron and hole pockets. The microscopic mechanism underlying the enhanced superconductivity in heavily electron-doped iron-selenide remains unclear. Here, we used neutron scattering to study the spin excitations of the heavily electron-doped iron-selenide material Li0...
July 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28742285/variable-expressivity-and-incomplete-penetrance-in-a-large-family-with-non-classical-diamond-blackfan-anemia-associated-with-ribosomal-protein-l11-splicing-variant
#13
Colleen M Carlston, Zeinab A Afify, Janice C Palumbos, Heidi Bagley, Carlos Barbagelata, Whitney L Wooderchak-Donahue, Rong Mao, John C Carey
Diamond-Blackfan anemia (DBA) is a group of clinically and genetically heterogeneous bone marrow failure disorders with or without congenital anomalies. Variable expressivity and incomplete penetrance have been observed within affected families. Diamond-Blackfan anemia-7 (DBA7), caused by heterozygous mutations in ribosomal protein L11 (RPL11), accounts for approximately 5% of DBA. DBA7 is usually characterized by early-onset bone marrow failure often accompanied by congenital malformations, especially thumb defects...
July 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28742061/test-study-of-boron-nitride-as-a-new-detector-material-for-dosimetry-in-high-energy-photon-beams
#14
Daniela Poppinga, Jannik Halbur, Sarah Lemmer, Bjoern Delfs, Dietrich Harder, Hui Khee Looe, Bjoern Poppe
The aim of this test study is to check whether boron nitride (BN) might be applied as a detector material in high energy photon-beam dosimetry. Boron nitride is a compound of boron and nitrogen and exists in various crystalline forms. Hexagonal boron nitride (h-BN) possesses high mobility of the electrons and holes as well as a high volume resistivity, so that ionizing radiation in the clinical range of the dose rate can be expected to produce a measurable electrical current at low background current. Due to the low atomic numbers of its atomic constituents, its density (2...
July 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28741934/mixed-spin-diamond-chain-cu2fepo4f4-h2o-4-with-a-noncollinear-spin-order-and-possible-successive-phase-transitions
#15
Hongcheng Lu, Naoaki Hayashi, Yuki Matsumoto, Hiroshi Takatsu, Hiroshi Kageyama
A diamond spin chain system, one of the one-dimensional frustrated lattices, is known to exhibit novel properties, but experimental studies have been exclusively confined to materials with a single spin component. Here, we report on the synthesis, structure, and magnetic properties of a new diamond chain compound Cu2FePO4F4(H2O)4 1 composed of mixed-spins of Cu(2+) (S = 1/2 × 2) and Fe(3+) (S = 5/2). Compound 1 crystallizes in the space group C2/c of the monoclinic crystal system with a = 7.7546(4) Å, b = 12...
July 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28738274/discovery-and-assessment-of-water-soluble-coumarins-as-inhibitors-of-the-coagulation-contact-pathway
#16
Charlotte Bouckaert, Shu Zhu, José W P Govers-Riemslag, Maxime Depoorter, Scott L Diamond, Lionel Pochet
Over the last decade, the coagulation factor XIIa (FXIIa) has seen renewed interest as a therapeutic target. Indeed, its inhibition could offer a protection against thrombosis without increasing the risk of bleeding. Moreover, it could answer the need for a safe prevention of blood-contacting medical devices-related thrombosis. Among the FXII and FXIIa inhibitors already described in literature, organic small-molecular-weight inhibitors are rather left behind. In this study, we were focused on the discovery and assessment of water soluble small molecules...
July 19, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28737910/raman-and-ir-spectroscopy-studies-on-propane-at-pressures-of-up-to-40-gpa
#17
Daniil Kudryavtsev, Aleksandr Serovaiskii, Elena Mukhina, Anton Kolesnikov, Biliana Gasharova, Vladimir Kutcherov, Leonid S Dubrovinsky
Raman and IR spectroscopy studies on propane were performed at pressures of up to 40 GPa at ambient temperatures using the diamond anvil cell technique. Propane undergoes three phase transitions at 6.4(5) GPa, 14.5(5) GPa, and 26.5(5) GPa in Raman spectroscopy and at 7.0(5) GPa, 14.0(5) GPa and 27.0(5) GPa in IR spectroscopy. The phase transitions were identified using the Raman and IR splitting modes and the appearance or disappearance of peaks, which clearly corresponded to the changes in the frequencies of the modes as the pressure changed...
July 24, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28734601/influence-of-saccharomyces-cerevisiae-fermentation-products-smartcare-in-milk-replacer-and-original-xpc-in-calf-starter-on-the-performance-and-health-of-preweaned-holstein-calves-challenged-with-salmonella-enterica-serotype-typhimurium
#18
T L Harris, Y Liang, K P Sharon, M D Sellers, I Yoon, M F Scott, J A Carroll, M A Ballou
This study was designed to investigate the effects of supplementing SmartCare (SC; Diamond V, Cedar Rapids, IA) in milk replacer and Original XPC (XPC; Diamond V) in calf starter on performance and health of preweaned calves following an oral challenge with Salmonella enterica. The study was performed in two 35-d periods with 30 Holstein bull calves (2 ± 1 d of age) per period. In each period, calves were blocked by location in the barn and randomly assigned to treatments that included control, base milk replacer and calf starter with no added Saccharomyces cerevisiae fermentation products; SC, milk replacer with 1 g of SC/calf per day and base calf starter; and SC+XPC, milk replacer with 1 g of SC/calf per day and calf starter with 0...
July 19, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28734221/treatment-of-highly-toxic-cardboard-plant-wastewater-by-a-combination-of-electrocoagulation-and-electrooxidation-processes
#19
Erhan Gengec
The objective of this study was to investigate the removal efficiencies of the electrochemical treatment systems as an alternative for the treatment of cardboard plant wastewater (CPW). In accordance with this purpose, CPW was treated by electrocoagulation (EC) with Al electrodes and the effects of current density (CD), operating time (t), and initial pH (pHi) were investigated. The results showed that EC at optimum treatment conditions (CD: 7.5mA/cm(2), pHi: 7.0 and t: 60min) have limited removal efficiencies for total organic carbon (TOC; 17...
July 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28733614/raman-evidence-for-pressure-induced-formation-of-diamondene
#20
Luiz Gustavo Pimenta Martins, Matheus J S Matos, Alexandre R Paschoal, Paulo T C Freire, Nadia F Andrade, Acrísio L Aguiar, Jing Kong, Bernardo R A Neves, Alan B de Oliveira, Mário S C Mazzoni, Antonio G Souza Filho, Luiz Gustavo Cançado
Despite the advanced stage of diamond thin-film technology, with applications ranging from superconductivity to biosensing, the realization of a stable and atomically thick two-dimensional diamond material, named here as diamondene, is still forthcoming. Adding to the outstanding properties of its bulk and thin-film counterparts, diamondene is predicted to be a ferromagnetic semiconductor with spin polarized bands. Here, we provide spectroscopic evidence for the formation of diamondene by performing Raman spectroscopy of double-layer graphene under high pressure...
July 21, 2017: Nature Communications
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