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Dental enamel hypoplasia

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https://www.readbyqxmd.com/read/28407772/the-end-of-a-dogma-the-safety-of-doxycycline-use-in-young-children-for-malaria-treatment
#1
REVIEW
Tiphaine Gaillard, Sébastien Briolant, Marylin Madamet, Bruno Pradines
Anti-malarial drug resistance to chloroquine and sulfadoxine-pyrimethamine has spread from Southeast Asia to Africa. Furthermore, the recent emergence of resistance to artemisinin-based combination therapy (ACT) in Southeast Asia highlights the need to identify new anti-malarial drugs. Doxycycline is recommended for malaria chemoprophylaxis for travel in endemic areas, or in combination with the use of quinine for malaria treatment when ACT is unavailable or when the treatment of severe malaria with artesunate fails...
April 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28407333/bioarchaeological-profile-of-stress-and-dental-disease-among-ancient-high-altitude-himalayan-communities-of-nepal
#2
Jacqueline T Eng, Mark Aldenderfer
OBJECTIVES: This study examines biological indicators of dental disease and nonspecific stress in human remains of three high altitude Himalayan archaeological sites to test whether shared ecological constraints led to similar bioarchaeological profiles in these markers. METHODS: Samples (n = 170) derive from three sites in Nepal dating to two periods (400-50 BCE and c. 400-650 CE). Dental diseases (caries, antemortem tooth loss, and abscesses) were assessed by both the number of individuals and the number of elements observed, while childhood stress markers included observation of growth disruptions (enamel hypoplasia and adult femur length/stature) and cranial porosities...
April 13, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28382465/significance-of-genetic-variations-in-developmental-enamel-defects-of-primary-dentition-in-polish-children
#3
Karolina Gerreth, Katarzyna Zaorska, Maciej Zabel, Michal Nowicki, Maria Borysewicz-Lewicka
OBJECTIVES: The aim of the study was to reveal the association between developmental defects of enamel (DDE) and single nucleotide polymorphisms (SNPs) in the ENAM, AMELX, AMBN, TUFT1, and TFIP11 genes. MATERIAL AND METHODS: The molecular analysis was carried out in 52 children, aged 10-42 months, from four nursery schools situated in the region of Poznan, Poland (26 individuals with hypomineralization and/or hypoplasia of enamel - "cases" and 26 unaffected children - "controls"), chosen from 262 individuals that had prior dental examination...
April 5, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28347809/developmental-defects-of-enamel-and-dental-caries-in-the-primary-dentition-a-systematic-review-and-meta-analysis
#4
REVIEW
Francine S Costa, Ethieli R Silveira, Gabriela S Pinto, Gustavo G Nascimento, William Murray Thomson, Flávio F Demarco
OBJECTIVES: This systematic review and meta-analysis evaluated the association between developmental defects of enamel and dental caries in the primary dentition. SOURCES: Electronic searches were performed in PubMed, Web of Knowledge, Scopus and Scielo for the identification of relevant studies. STUDY SELECTION: Observational studies that examined the association between developmental defects of enamel and dental caries in the deciduous dentition were included...
March 24, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28258662/a-novel-gja1-mutation-in-oculodentodigital-dysplasia-with-extensive-loss-of-enamel
#5
T Porntaveetus, C Srichomthong, A Ohazama, K Suphapeetiporn, V Shotelersuk
OBJECTIVE: To characterize clinical features and identify genetic causes of a patient with oculodentodigital dysplasia (ODDD). SUBJECTS AND METHODS: Clinical, dental, radiological features were obtained. DNA was collected from an affected Thai family. Whole-exome sequencing was employed to identify the disease-causing mutation causing ODDD. The presence of the identified variant was confirmed by Sanger sequencing. RESULTS: The proband suffered with extensive enamel hypoplasia, polysyndactyly and clinodactyly of the 3rd-5th fingers, microphthalmia, and unique facial characteristics of ODDD...
March 4, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28251719/high-altitude-agriculture-in-the-titicaca-basin-800-bce-200-ce-impacts-on-nutrition-and-disease-load
#6
Sara L Juengst, Dale L Hutchinson, Sergio J Chávez
OBJECTIVES: This study investigates the biological impacts of sedentism and agriculture on humans living in the high altitude landscape of the Titicaca Basin between 800 BCE and CE 200. The transition to agriculture in other global areas resulted in increases in disease and malnutrition; the high altitude of the Titicaca Basin could have exacerbated this. Our objective is to test whether the high altitude of the Titicaca Basin created a marginal environment for early agriculturalists living there, reflected through elevated rates of malnutrition and/or disease...
March 2, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28243307/a-case-report-of-dilacerated-crown-of-a-permanent-mandibular-central-incisor
#7
Behnam Bolhari, Salma Pirmoazen, Ensieh Taftian, Somayeh Dehghan
Trauma to primary teeth can lead to devastating sequels in development of permanent successors. The disturbance may range from enamel hypoplasia and/or hypo-calcification to arrest of dental bud development. Crown dilaceration of permanent teeth is one of the consequences of trauma to deciduous teeth mainly due to intrusion or avulsion. This report presents a mandibular central incisor with dilacerated crown and yellowish discoloration with symptomatic apical abscess. History revealed avulsion of primary mandibular central incisors...
November 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28211566/applying-standard-perikymata-profiles-to-pongo-pygmaeus-canines-to-estimate-perikymata-counts-between-linear-enamel-hypoplasias
#8
Mackie O'Hara
OBJECTIVES: Recently, studies have interpreted regular spacing and average number of perikymata between dental enamel defects in orangutans to reflect seasonal episodes of physiological stress. To estimate the amount of time between developmental defects (enamel hypoplasia), studies have relied on perikymata counts. Unfortunately, perikymata are frequently not continuously visible between defects, significantly reducing data sets. A method is presented here for estimating the number of perikymata between defects using standard perikymata profiles (SPP) that allow the number of perikymata between all pairs of defects across a tooth to be analyzed...
May 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28194533/the-diagnostic-accuracy-of-a-laser-fluorescence-device-and-digital-radiography-in-detecting-approximal-caries-lesions-in-posterior-permanent-teeth-an-in-vivo-study
#9
R Menem, I Barngkgei, N Beiruti, I Al Haffar, Easter Joury
The aim of this in vivo study was to test the diagnostic accuracy of a pen-type laser fluorescence (LFpen) device in detecting approximal caries lesions, in posterior permanent teeth, at the cavitation and non-cavitation thresholds, and compare it with that of digital bitewing radiography. Thirty patients (aged 18-37), who attended the Faculty of Dentistry at Damascus University for a dental examination, were consecutively screened. Ninety approximal surfaces of posterior permanent teeth without frank cavitations, enamel hypoplasia or restorations were selected and examined using the LFpen (DIAGNOdent pen) and digital bitewing radiography...
April 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28191355/morquio-s-syndrome-a-case-report-of-two-siblings
#10
Sathish Muthukumar Ramalingam, Daya Srinivasan, Sandhya ArunKumar, Joe Louis ChiriyanKandath, Sriram Kaliamoorthy
Morquio syndrome or MPS IVA is a rare type of lysosomal storage disease associated with highly specific dental abnormalities. We present two siblings with enamel hypoplasia and skeletal abnormalities. A diagnosis of mucopolysaccharidosis type IVA was reached based on the clinical, radiographic, and dental findings of the patients. The dental findings are useful diagnostic aid for the early diagnosis of this debilitating disorder.
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28095448/distribution-of-cathepsin-k-in-late-stage-of-tooth-germ-development-and-its-function-in-degrading-enamel-matrix-proteins-in-mouse
#11
Tao Jiang, Fen Liu, Wei-Guang Wang, Xin Jiang, Xuan Wen, Kai-Jin Hu, Yang Xue
Cathepsin K (CTSK) is a member of cysteine proteinase family, and is predominantly expressed in osteoclastsfor degradationof bone matrix proteins. Given the similarity in physical properties of bone and dental mineralized tissues, including enamel, dentin and cementum, CTSK is likely to take part in mineralization process during odontogenesis. On the other hand, patients with pycnodysostosis caused by mutations of the CTSK gene displayedmultipledental abnormalities, such as hypoplasia of the enamel, obliterated pulp chambers, hypercementosis and periodontal disease...
2017: PloS One
https://www.readbyqxmd.com/read/28081373/loss-of-function-of-evc2-in-dental-mesenchyme-leads-to-hypomorphic-enamel
#12
H Zhang, H Takeda, T Tsuji, N Kamiya, T Kunieda, Y Mochida, Y Mishina
Ellis-van Creveld (EvC) syndrome is an autosomal-recessive skeletal dysplasia, characterized by short stature and postaxial polydactyly. A series of dental abnormalities, including hypomorphic enamel formation, has been reported in patients with EvC. Despite previous studies that attempted to uncover the mechanism leading to abnormal tooth development, little is known regarding how hypomorphic enamel is formed in patients with EvC. In the current study, using Evc2/ Limbin mutant mice we recently generated, we analyzed enamel formation in the mouse incisor...
April 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28052204/dental-anomalies-in-permanent-teeth-after-trauma-in-primary-dentition
#13
Elena Bardellini, Francesca Amadori, Stefania Pasini, Alessandra Majorana
OBJECTIVE: This retrospective study aims to evaluate the prevalence of dental anomalies in permanent teeth as a result of a trauma concerning the predecessor primary teeth. STUDY DESIGN: A total of 241 records of children (118 males and 123 females, mean age 3.62 ± 1.40) affected by trauma on primary teeth were analyzed. All patients were recalled to evaluate the status of the permanent successor teeth by clinical and radiographic investigations. RESULTS: Out of 241 patients, 106 patients (for a total of 179 traumatized primary teeth) presented at the recall...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28045325/oral-manifestations-of-gastrointestinal-diseases-in-children-part-4-coeliac-disease
#14
C Mantegazza, M Paglia, F Angiero, R Crippa
Alterations within the oral cavity can be the first sign of systemic diseases and may thus allow for an early diagnosis and treatment. In particular, being the oral cavity part of the gastrointestinal system, oral alterations can be an expression of a gastrointestinal disease. Dental enamel hypoplasia and aphthous ulcers have been found to be more common in children with coeliac disease compared with the general population and to regress after the patient is started on a gluten free-diet. A prompt recognition of systemic diseases through a careful examination of the oral cavity could allow the child to have appropriate investigations and to be treated in a timely fashion...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28043400/dental-issues-in-lacrimo-auriculo-dento-digital-syndrome-an-autosomal-dominant-condition-with-clinical-and-genetic-variability
#15
M J Hajianpour, Hannah Bombei, Scott M Lieberman, Rachael Revell, Rachana Krishna, Robert Gregorsok, Simon Kao, Jeff M Milunsky
BACKGROUND AND OVERVIEW: Lacrimo-auriculo-dento-digital (LADD) syndrome is an autosomal dominant disorder with variable lacrimal and salivary gland hypoplasia and aplasia, auricular anomalies and hearing loss, dental defects and caries, and digital anomalies. CASE DESCRIPTION: The authors present the cases of 2 unrelated children with enamel defects and history of dry mouth leading to recurrent dental caries. The referring diagnoses were Sjögren disease and hypohidrotic ectodermal dysplasia, respectively...
March 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/27989366/dental-and-temporomandibular-joint-pathology-of%C3%A2-the-american-black-bear-ursus-americanus
#16
E J Clark, S R Chesnutt, J N Winer, P H Kass, F J M Verstraete
Museum specimens (maxillae and/or mandibles) from 371 American black bears (Ursus americanus) acquired between 1889 and 2006 were examined macroscopically according to predefined criteria, and 348 were included in this study. Of the 348 specimens, 126 (36.2%) were from male animals, 106 (30.5%) were from female animals and 116 (33.3%) were from animals of unknown sex. Specimen ages ranged from young adult (n = 63, 18.1%) to adult (n = 285, 81.9%), with juveniles excluded from the study. The number of teeth available for examination was 12,019 (82...
December 15, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27908555/dental-pathology-of-the-hoary-marmot-marmota-caligata-groundhog-marmota-monax-and-alaska-marmot-marmota-broweri
#17
J N Winer, B Arzi, D M Leale, P H Kass, F J M Verstraete
Museum specimens (maxillae and mandibles) of the three marmot species occurring in Alaska (Marmota caligata [n = 108 specimens], Marmota monax [n = 30] and Marmota broweri [n = 24]) were examined macroscopically according to predefined criteria. There were 71 specimens (43.8%) from female animals, 69 (42.6%) from male animals and 22 (13.6%) from animals of unknown sex. The ages of animals ranged from neonatal to adult, with 121 young adults (74.4%) and 41 adults (25.3%) included, and 168 excluded from study due to neonatal/juvenile age or incompleteness of specimens (missing part of the dentition)...
November 28, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27848202/prevalence-of-enamel-defects-and-association-with-dental-caries-in-preschool-children
#18
C Massignan, M Ximenes, C da Silva Pereira, L Dias, M Bolan, M Cardoso
AIM: This was to evaluate the prevalence of the developmental defects of enamel (DDE) in primary teeth and its association with dental caries. METHODS: A cross-sectional study with a randomised representative sample was carried out with 1101 children aged 2-5 years enrolled in public preschools (50% prevalence of DDE in primary teeth, a standard error of 3%, and a confidence level of 95%). Three calibrated dentists (K > 0.62) performed clinical examination...
December 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/27778394/use-of-new-targeted-cancer-therapies-in-children-effects-on-dental-development-and-risk-of-jaw-osteonecrosis-a-review
#19
Magali Hernandez, Bérengère Phulpin, Ludovic Mansuy, Dominique Droz
New targeted cancer therapies such as bisphosphonates, denosumab and bevacizumab are routinely used in adult for the past decades. Their introduction into pediatric medicine is more recent that means there is a paucity of data on long-term effects on dental development and on the risk of osteonecrosis of jaw. This paper aims to outline adverse effects of new targeted cancer therapies on oral cavity including dental abnormalities observed in pediatric population treated with these molecules and the risk of osteonecrosis of the jaw (ONJ)...
October 25, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27760456/dlx3-dependent-regulation-of-ion-transporters-and-carbonic-anhydrases-is-crucial-for-enamel-mineralization
#20
Olivier Duverger, Takahiro Ohara, Paul W Bible, Angela Zah, Maria I Morasso
Patients with tricho-dento-osseous (TDO) syndrome, an ectodermal dysplasia caused by mutations in the homeodomain transcription factor DLX3, exhibit enamel hypoplasia and hypomineralization. Here we used a conditional knockout mouse model to investigate the developmental and molecular consequences of Dlx3 deletion in the dental epithelium in vivo. Dlx3 deletion in the dental epithelium resulted in the formation of chalky hypomineralized enamel in all teeth. Interestingly, transcriptomic analysis revealed that major enamel matrix proteins and proteases known to be involved in enamel secretion and maturation were not affected significantly by Dlx3 deletion in the enamel organ...
October 19, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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