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Dental enamel hypoplasia

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https://www.readbyqxmd.com/read/28095448/distribution-of-cathepsin-k-in-late-stage-of-tooth-germ-development-and-its-function-in-degrading-enamel-matrix-proteins-in-mouse
#1
Tao Jiang, Fen Liu, Wei-Guang Wang, Xin Jiang, Xuan Wen, Kai-Jin Hu, Yang Xue
Cathepsin K (CTSK) is a member of cysteine proteinase family, and is predominantly expressed in osteoclastsfor degradationof bone matrix proteins. Given the similarity in physical properties of bone and dental mineralized tissues, including enamel, dentin and cementum, CTSK is likely to take part in mineralization process during odontogenesis. On the other hand, patients with pycnodysostosis caused by mutations of the CTSK gene displayedmultipledental abnormalities, such as hypoplasia of the enamel, obliterated pulp chambers, hypercementosis and periodontal disease...
2017: PloS One
https://www.readbyqxmd.com/read/28081373/loss-of-function-of-evc2-in-dental-mesenchyme-leads-to-hypomorphic-enamel
#2
H Zhang, H Takeda, T Tsuji, N Kamiya, T Kunieda, Y Mochida, Y Mishina
Ellis-van Creveld (EvC) syndrome is an autosomal-recessive skeletal dysplasia, characterized by short stature and postaxial polydactyly. A series of dental abnormalities, including hypomorphic enamel formation, has been reported in patients with EvC. Despite previous studies that attempted to uncover the mechanism leading to abnormal tooth development, little is known regarding how hypomorphic enamel is formed in patients with EvC. In the current study, using Evc2/ Limbin mutant mice we recently generated, we analyzed enamel formation in the mouse incisor...
December 1, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/28052204/dental-anomalies-in-permanent-teeth-after-trauma-in-primary-dentition
#3
Elena Bardellini, Francesca Amadori, Stefania Pasini, Alessandra Majorana
OBJECTIVE: This retrospective study aims to evaluate the prevalence of dental anomalies in permanent teeth as a result of a trauma concerning the predecessor primary teeth. STUDY DESIGN: A total of 241 records of children (118 males and 123 females, mean age 3.62 ± 1.40) affected by trauma on primary teeth were analyzed. All patients were recalled to evaluate the status of the permanent successor teeth by clinical and radiographic investigations. RESULTS: Out of 241 patients, 106 patients (for a total of 179 traumatized primary teeth) presented at the recall...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28045325/oral-manifestations-of-gastrointestinal-diseases-in-children-part-4-coeliac-disease
#4
C Mantegazza, M Paglia, F Angiero, R Crippa
Alterations within the oral cavity can be the first sign of systemic diseases and may thus allow for an early diagnosis and treatment. In particular, being the oral cavity part of the gastrointestinal system, oral alterations can be an expression of a gastrointestinal disease. Dental enamel hypoplasia and aphthous ulcers have been found to be more common in children with coeliac disease compared with the general population and to regress after the patient is started on a gluten free-diet. A prompt recognition of systemic diseases through a careful examination of the oral cavity could allow the child to have appropriate investigations and to be treated in a timely fashion...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28043400/dental-issues-in-lacrimo-auriculo-dento-digital-syndrome-an-autosomal-dominant-condition-with-clinical-and-genetic-variability
#5
M J Hajianpour, Hannah Bombei, Scott M Lieberman, Rachael Revell, Rachana Krishna, Robert Gregorsok, Simon Kao, Jeff M Milunsky
BACKGROUND AND OVERVIEW: Lacrimo-auriculo-dento-digital (LADD) syndrome is an autosomal dominant disorder with variable lacrimal and salivary gland hypoplasia and aplasia, auricular anomalies and hearing loss, dental defects and caries, and digital anomalies. CASE DESCRIPTION: The authors present the cases of 2 unrelated children with enamel defects and history of dry mouth leading to recurrent dental caries. The referring diagnoses were Sjögren disease and hypohidrotic ectodermal dysplasia, respectively...
December 30, 2016: Journal of the American Dental Association
https://www.readbyqxmd.com/read/27989366/dental-and-temporomandibular-joint-pathology-of%C3%A2-the-american-black-bear-ursus-americanus
#6
E J Clark, S R Chesnutt, J N Winer, P H Kass, F J M Verstraete
Museum specimens (maxillae and/or mandibles) from 371 American black bears (Ursus americanus) acquired between 1889 and 2006 were examined macroscopically according to predefined criteria, and 348 were included in this study. Of the 348 specimens, 126 (36.2%) were from male animals, 106 (30.5%) were from female animals and 116 (33.3%) were from animals of unknown sex. Specimen ages ranged from young adult (n = 63, 18.1%) to adult (n = 285, 81.9%), with juveniles excluded from the study. The number of teeth available for examination was 12,019 (82...
December 15, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27908555/dental-pathology-of-the-hoary-marmot-marmota-caligata-groundhog-marmota-monax-and-alaska-marmot-marmota-broweri
#7
J N Winer, B Arzi, D M Leale, P H Kass, F J M Verstraete
Museum specimens (maxillae and mandibles) of the three marmot species occurring in Alaska (Marmota caligata [n = 108 specimens], Marmota monax [n = 30] and Marmota broweri [n = 24]) were examined macroscopically according to predefined criteria. There were 71 specimens (43.8%) from female animals, 69 (42.6%) from male animals and 22 (13.6%) from animals of unknown sex. The ages of animals ranged from neonatal to adult, with 121 young adults (74.4%) and 41 adults (25.3%) included, and 168 excluded from study due to neonatal/juvenile age or incompleteness of specimens (missing part of the dentition)...
November 28, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27848202/prevalence-of-enamel-defects-and-association-with-dental-caries-in-preschool-children
#8
C Massignan, M Ximenes, C da Silva Pereira, L Dias, M Bolan, M Cardoso
AIM: This was to evaluate the prevalence of the developmental defects of enamel (DDE) in primary teeth and its association with dental caries. METHODS: A cross-sectional study with a randomised representative sample was carried out with 1101 children aged 2-5 years enrolled in public preschools (50% prevalence of DDE in primary teeth, a standard error of 3%, and a confidence level of 95%). Three calibrated dentists (K > 0.62) performed clinical examination...
December 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/27778394/use-of-new-targeted-cancer-therapies-in-children-effects-on-dental-development-and-risk-of-jaw-osteonecrosis-a-review
#9
Magali Hernandez, Bérengère Phulpin, Ludovic Mansuy, Dominique Droz
New targeted cancer therapies such as bisphosphonates, denosumab and bevacizumab are routinely used in adult for the past decades. Their introduction into pediatric medicine is more recent that means there is a paucity of data on long-term effects on dental development and on the risk of osteonecrosis of jaw. This paper aims to outline adverse effects of new targeted cancer therapies on oral cavity including dental abnormalities observed in pediatric population treated with these molecules and the risk of osteonecrosis of the jaw (ONJ)...
October 25, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27760456/dlx3-dependent-regulation-of-ion-transporters-and-carbonic-anhydrases-is-crucial-for-enamel-mineralization
#10
Olivier Duverger, Takahiro Ohara, Paul W Bible, Angela Zah, Maria I Morasso
Patients with Tricho-Dento-Osseous syndrome, an ectodermal dysplasia caused by mutations in the homeodomain transcription factor DLX3, exhibit enamel hypoplasia and hypomineralization. Here we used a conditional knockout mouse model to investigate the developmental and molecular consequences of Dlx3 deletion in the dental epithelium in vivo. Dlx3 deletion in the dental epithelium resulted in the formation of chalky hypomineralized enamel in all teeth. Interestingly, transcriptomic analysis revealed that major enamel matrix proteins and proteases known to be involved in enamel secretion and maturation were not affected significantly by Dlx3 deletion in the enamel organ...
October 19, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27696357/disturbances-and-noise-defining-furrow-form-enamel-hypoplasia
#11
E Bocaege, S Hillson
OBJECTIVES: The investigation of the record of growth locked in dental enamel provides a unique opportunity to build a comprehensive picture of growth disruption episodes during childhood. This study presents a new methodological basis for the analysis of enamel growth disruptions (enamel hypoplasia) using incremental microstructures of enamel. METHODS: A three-dimensional technique based upon use of an Alicona 3D Infinite Focus imaging microscope and software is used to record developmental features in the enamel of human permanent mandibular lateral incisors of one individual from the Neolithic site of Çatalhöyük (Turkey)...
December 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27692425/orthodontic-treatment-and-follow-up-of-a-patient-with-cerebral-palsy-and-spastic-quadriplegia
#12
Muhsin Çifter, Nil Cura
INTRODUCTION: This report describes the clinical orthodontic management of a patient with spastic quadriplegia and cerebral palsy. Guidelines to overcome difficulties encountered during the treatment period are suggested. METHODS: A 13-year-old boy with cerebral palsy and spastic quadriplegia complained of an undesirable oral appearance because of his malocclusion. He had a Class II molar relationship, with severe maxillary and moderate mandibular anterior crowding...
October 2016: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27689858/long-term-effect-of-chemotherapy-intensity-modulated-radiation-therapy-chemo-imrt-on-dentofacial-development-in-head-and-neck-rhabdomyosarcoma-patients
#13
Adepitan A Owosho, Paul Brady, Suzanne L Wolden, Leonard H Wexler, Cristina R Antonescu, Joseph M Huryn, Cherry L Estilo
Dentofacial developmental abnormalities have been reported in head and neck rhabdomyosarcoma (HNRMS) patients treated with conventional radiotherapy technique and chemotherapy. This current study investigates dentofacial long-term effects among HNRMS survivors managed with intensity-modulated radiotherapy (IMRT) and chemotherapy. In general, IMRT is a more effective 3D-conformal radiotherapy technique, which delivers high doses of radiation to the tumor target while minimizing doses received by the surrounding normal tissues...
September 2016: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/27643784/dental-enamel-defects-in-german-medieval-and-early-modern-age-populations
#14
J Lang, S Birkenbeil, S Bock, R Heinrich-Weltzien, K Kromeyer-Hauschild
Aim of this study was to investigate the frequency and type of developmental defects of enamel (DDE) in a medieval and an early-modern-age population from Thuringia, Germany. Sixty-six skeletons subdivided into 31 single burials (12(th)/13(th) c.) and 35 individuals buried in groups (15(th)/16(th) c.) were examined. DDE were classified on 1,246 teeth according to the DDE index. Molar-incisor-hypomineralisation (MIH), a special type of DDE, was recorded according to the European Academy of Paediatric Dentistry (EAPD) criteria...
August 25, 2016: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/27617510/a-rare-case-epidermolysis-bullosa-in-a-child-patient-with-amelogenesis-imperfecta
#15
H Karayilmaz, Öe Güngör, S Hanimeli, B Yagmur
Epidermolysis bullosa (EB) is an inherited disorder affecting the skin and mucous membranes, characterized by blister formation following minor trauma. It is a chronic mechanobullous disease related to the specific abnormal or absent proteins. The disease is associated with conspicuous clinical and oral manifestations. The oral involvement of EB includes generalized enamel hypoplasia, dental caries, limited mouth opening, ankyloglossia, microstomia and obliteration of the vestibule. Amelogenesis imperfecta (AI) is a hereditary disorder with dental enamel defects and enamel hypoplasia both in deciduous and permanent dentition...
February 26, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/27599287/enamel-hypoplasia-challenges-of-esthetic-restorative-treatment
#16
Vanessa Carla Ruschel, Élito Araújo, Jussara Karina Bernardon, Guilherme Carpena Lopes
Enamel defects, such as white or yellow-brown spots, usually cause problems that are more esthetic than functional. Enamel hypoplasia may be the result of hereditary, systemic, or local factors. Dental trauma is a local etiologic factor. It is relatively common in the primary dentition and can cause defects on the surface of permanent successors. Treatment for such defects can differ, depending on the depth of the spots. For deeper white-spot lesions, a composite resin restoration may be necessary. This is an excellent mode of treatment, due to both its low cost and its conservation of healthy tooth structure...
September 2016: General Dentistry
https://www.readbyqxmd.com/read/27530539/dental-and-temporomandibular-joint-pathology-of-the-walrus-odobenus-rosmarus
#17
J N Winer, B Arzi, D M Leale, P H Kass, F J M Verstraete
Maxillae and/or mandibles from 76 walruses (Odobenus rosmarus) were examined macroscopically according to predefined criteria. The museum specimens were acquired between 1932 and 2014. Forty-five specimens (59.2%) were from male animals, 29 (38.2%) from female animals and two (2.6%) from animals of unknown sex, with 58 adults (76.3%) and 18 young adults (23.7%) included in this study. The number of teeth available for examination was 830 (33.6%); 18.5% of teeth were absent artefactually, 3.3% were deemed to be absent due to acquired tooth loss and 44...
August 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27508165/application-of-quantitative-light-induced-fluorescence-to-determine-the-depth-of-demineralization-of-dental-fluorosis-in-enamel-microabrasion-a-case-report
#18
Tae-Young Park, Han-Sol Choi, Hee-Won Ku, Hyun-Su Kim, Yoo-Jin Lee, Jeong-Bum Min
Enamel microabrasion has become accepted as a conservative, nonrestorative method of removing intrinsic and superficial dysmineralization defects from dental fluorosis, restoring esthetics with minimal loss of enamel. However, it can be difficult to determine if restoration is necessary in dental fluorosis, because the lesion depth is often not easily recognized. This case report presents a method for analysis of enamel hypoplasia that uses quantitative light-induced fluorescence (QLF) followed by a combination of enamel microabrasion with carbamide peroxide home bleaching...
August 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27475682/impact-of-rare-diseases-in-oral-health
#19
A Molina-García, L Castellanos-Cosano, G Machuca-Portillo, M Posada-de la Paz
BACKGROUND: Rare diseases (RD) are those that present a lower prevalence than 5 cases per 10.000 population. The main objective of this review was to study the effect on oral health in rare diseases, while the secondary objective of the study is theme upgrade. MATERIAL AND METHODS: Comparative observational case-control studies were analysed and a systematic review was conducted in PubMed. Each rare disease listed on the statistical data record of the Health Portal of the Ministry of Equality, Health and Social Policies Board of Andalusia was associated with "oral health"...
September 1, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27430583/prevalence-of-developmental-dental-hard-tissue-anomalies-and-association-with-caries-and-oral-hygiene-status-of-children-in-southwestern-nigeria
#20
Bamidele O Popoola, Nneka Onyejaka, Morenike O Folayan
BACKGROUND: Developmental dental hard tissue anomalies are often associated with oral health problems. This study determined the clinical prevalence of developmental dental hard tissue anomalies in the permanent dentition of children resident in southwestern Nigeria and its association with dental caries and poor oral hygiene status. METHODS: This was a cross-sectional study recruiting 1565 school children, 12 to 15 year old attending schools in Ibadan, Oyo State and Ile-Ife, Osun State...
2016: BMC Oral Health
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