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Vitamin B5

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https://www.readbyqxmd.com/read/27900284/effect-of-pantethine-on-ovarian-tumor-progression-and-choline-metabolism
#1
Marie-France Penet, Balaji Krishnamachary, Flonne Wildes, Yelena Mironchik, Delia Mezzanzanica, Franca Podo, Max de Reggi, Bouchra Gharib, Zaver M Bhujwalla
Epithelial ovarian cancer remains the leading cause of death from gynecologic malignancy among women in developed countries. New therapeutic strategies evaluated with relevant preclinical models are urgently needed to improve survival rates. Here, we have assessed the effect of pantethine on tumor growth and metabolism using magnetic resonance imaging and high-resolution proton magnetic resonance spectroscopy (MRS) in a model of ovarian cancer. To evaluate treatment strategies, it is important to use models that closely mimic tumor growth in humans...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27758107/untargeted-metabolomics-analysis-of-abcc6-deficient-mice-discloses-an-altered-metabolic-liver-profile
#2
Mie Rostved Rasmussen, Kirstine Lykke Nielsen, Mia Roest Laursen, Camilla Bak Nielsen, Pia Svendsen, Henrik Dimke, Erik Ilsø Christensen, Mogens Johannsen, Søren Kragh Moestrup
Loss-of-function mutations in the transmembrane ABCC6 transport protein cause pseudoxanthoma elasticum - an ectopic, metabolic mineralization disorder affecting the skin, eye and vessels. ABCC6 is assumed to mediate efflux of one or several small molecule compounds from the liver cytosol to the circulation. Untargeted metabolomics using liquid chromatography mass spectrometry was employed to inspect liver cytosolic extracts from mice with targeted disruption of the Abcc6 gene. Absence of the ABCC6 protein induced an altered profile of metabolites in the liver causing accumulation of compounds as more features were upregulated than downregulated in ABCC6-deficient mice...
October 19, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27659871/development-and-application-of-novelty-pretreatment-method-for-the-concurrent-quantitation-of-eleven-water-soluble-b-vitamins-in-ultrafiltrates-after-renal-replacement-therapy
#3
Dorota Wirkus, Aleksandra Jakubus, Radosław Owczuk, Piotr Stepnowski, Monika Paszkiewicz
Continous renal replacement therapy (CRRT) is particularly recommended for septic shock patients in intensive care units. The CRRT technique used most frequently is high volume continuous veno-venous haemofiltration. It provides a high rate of clearance of uremic toxins and inflammatory cytokines. However, it should also be taken into account that substances important for homeostasis may be concurrently unintentionally removed. Accordingly, water-soluble vitamins can be removed during continuous renal replacement therapy, and the estimate of the loss is critical to ensure appropriate supplementation...
September 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27644319/genetic-characterization-of-plasmodium-putative-pantothenate-kinase-genes-reveals-their-essential-role-in-malaria-parasite-transmission-to-the-mosquito
#4
Robert J Hart, Emmanuel Cornillot, Amanah Abraham, Emily Molina, Catherine S Nation, Choukri Ben Mamoun, Ahmed S I Aly
The metabolic machinery for the biosynthesis of Coenzyme A (CoA) from exogenous pantothenic acid (Vitamin B5) has long been considered as an excellent target for the development of selective antimicrobials. Earlier studies in the human malaria parasite Plasmodium falciparum have shown that pantothenate analogs interfere with pantothenate phosphorylation and block asexual blood stage development. Although two eukaryotic-type putative pantothenate kinase genes (PanK1 and PanK2) have been identified in all malaria parasite species, their role in the development of Plasmodium life cycle stages remains unknown...
September 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27639524/effect-of-acoustically-assisted-treatments-on-vitamins-antioxidant-activity-organic-acids-and-drying-kinetics-of-pineapple
#5
Óscar Rodríguez, Wesley Gomes, Sueli Rodrigues, Fabiano A N Fernandes
The effects of the application of an acoustically assisted treatment on the vitamins (C, B1, B2, B3, and B5), the antioxidant activity (DPPH, FRAP), the polyphenol and flavonoid contents, the organic acid contents (citric and malic) and drying kinetics of pineapple (Ananas comosus var. Perola) have been studied. Treatments were carried out using two different soaking media: distilled water and pineapple juice at 30°C during 10, 20 and 30min without and with acoustic assistance (23.2W/L). After treatment, samples were dried at 60°C and 0...
March 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27506358/a-new-sample-preparation-and-separation-combination-for-precise-accurate-rapid-and-simultaneous-determination-of-vitamins-b1-b2-b3-b5-b6-b7-and-b9-in-infant-formula-and-related-nutritionals-by-lc-ms-ms
#6
Nicholas A Cellar, Sean C McClure, Louis M Salvati, Todime M Reddy
An improved method was developed for simultaneous determination of the fortified forms of thiamine (B1), riboflavin (B2), nicotinamide and nicotinic acid (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), and folic acid (B9) in infant formulas and related nutritionals. The method employed a simple, effective, and rapid sample preparation followed by liquid chromatography tandem mass spectrometry (LC-MS/MS). It improved upon previous methodologies by offering facile and rugged sample preparation with improved chromatographic conditions, which culminated in a highly accurate and precise method for water-soluble vitamin determination in a wide range of formulas...
August 31, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27477998/life-s-utilization-of-b-vitamins-on-early-earth
#7
D R Monteverde, L Gómez-Consarnau, C Suffridge, S A Sañudo-Wilhelmy
Coenzymes are essential across all domains of life. B vitamins (B1 -thiamin, B2 -riboflavin, B3 -niacin, B5 -pantothenate, B6 -pyridoxine, B7 -biotin, and B12 -cobalamin) represent the largest class of coenzymes, which participate in a diverse set of reactions including C1 -rearrangements, DNA repair, electron transfer, and fatty acid synthesis. B vitamin structures range from simple to complex heterocycles, yet, despite this complexity, multiple lines of evidence exist for their ancient origins including abiotic synthesis under putative early Earth conditions and/or meteorite transport...
July 31, 2016: Geobiology
https://www.readbyqxmd.com/read/27432261/feeding-behavior-and-dietary-intake-of-male-children-and-adolescents-with-autism-spectrum-disorder-a-case-control-study
#8
Kamila Castro, Larissa Slongo Faccioli, Diego Baronio, Carmem Gottfried, Ingrid Schweigert Perry, Rudimar Riesgo
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with restrictive or repetitive behaviors and difficulties with verbal and interpersonal communication, in which some problems involving nutrition may be present. This study aims to evaluate dietary intake and identify feeding behavioral problems in male children and adolescents with ASD when compared to matched controls, as well as parents or caregivers' feelings about strategies for dealing with eating problems. A 3-day food record was performed and nutrient intake was compared to the Dietary Reference Intake according to age...
October 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/27113113/metabolomics-reveals-an-involvement-of-pantothenate-for-male-production-responding-to-the-short-day-stimulus-in-the-water-flea-daphnia-pulex
#9
Kenji Toyota, Alex Gavin, Shinichi Miyagawa, Mark R Viant, Taisen Iguchi
Under favorable conditions, the micro-crustacean Daphnia pulex produces female offspring by parthenogenesis, whereas under unfavorable conditions, they produce male offspring to induce sexual reproduction (environmental sex determination: ESD). We recently established a suitable system for ESD studies using D. pulex WTN6 strain, in which the sex of the offspring can be regulated by alterations in day-length; long-day and short-day conditions can induce female and male offspring, respectively. Taking advantage of this system, we have already demonstrated that methyl farnesoate (MF) synthesis is necessary for male offspring production, and identified ionotropic glutamate receptors as an upstream regulator of MF signaling...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27085042/fabrication-and-characterization-of-vitamin-b5-loaded-poly-l-lactide-co-caprolactone-silk-fiber-aligned-electrospun-nanofibers-for-schwann-cell-proliferation
#10
M Aqeel Bhutto, Tong Wu, Binbin Sun, Hany Ei-Hamshary, Salem S Al-Deyab, Xiumei Mo
Bioengineering strategies for peripheral nerve regeneration have been focusing on the development of alternative treatments for nerve repair. In present study we have blended the Vitamin B5 (50mg) with 8% P(LLA-CL) and P(LLA-CL)/SF solutions and produced aligned electrospun nanofiber mashes and characterized the material for its physiochemical and mechanical characteristics. The vitamin loaded composites nanofibers showed tensile strength of 8.73±1.38 and 8.4±1.37 in P(LLA-CL)/Vt and P(LLA-CL)/SF/Vt nanofibers mashes, respectively...
August 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27053467/new-methods-for-the-analysis-of-water-soluble-vitamins-in-infant-formula-and-adult-pediatric-nutritionals
#11
Frederic Martin, Ester Campos Giménez, Erik Konings
Water-soluble vitamins (WSVs) are a group of organic compounds which are essential micronutrients. WSVs could be divided between the B complex group and vitamin C (l-ascorbic acid). Within the B complex group, eight vitamins are recognized: vitamins B1 (thiamin), B2 (riboflavin), B3 (niacin or niacinamide), B5 (pantothenic acid), B6 (pyridoxine, pyridoxal, or pyridoxamine), B7 (biotin), B9 (folic acid), and B12 (various cobalamins). This paper reviews the new methods for the analysis of these vitamins, with a focus on infant formula and adult nutritionals...
January 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/26932716/genetic-and-pharmacological-inhibition-of-vanin-1-activity-in-animal-models-of-type-2-diabetes
#12
Janna A van Diepen, Patrick A Jansen, Dov B Ballak, Anneke Hijmans, Floris P J T Rutjes, Cees J Tack, Mihai G Netea, Joost Schalkwijk, Rinke Stienstra
Vanins are enzymes that convert pantetheine to pantothenic acid (vitamin B5). Insights into the function of vanins have evolved lately, indicating vanin-1 to play a role in inflammation, oxidative stress and cell migration. Moreover, vanin-1 has recently gained attention as a novel modulator of hepatic glucose and lipid metabolism. In the present study, we investigated the role of vanin-1 in the development of hepatic steatosis and insulin resistance in animal models of obesity and diabetes. In addition, we evaluated the potency of RR6, a novel pharmacological vanin-1 inhibitor, as an anti-diabetic drug...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26828840/optic-atrophy-in-a-patient-with-atypical-pantothenate-kinase-associated-neurodegeneration
#13
Jinu Han, Do Wook Kim, Chul-Ho Lee, Sueng-Han Han
Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive neurodegeneration with brain iron accumulation and characterized by extrapyramidal signs, vision loss, and intellectual decline. PKAN is caused by mutations in the PANK2 gene, which codes for a mitochondrial enzyme that phosphorylates vitamin B5 in the first reaction of the coenzyme A biosynthetic pathway. Visual failure in this disorder is typically due to pigmentary retinopathy. Yet our patient, a 13-year-old girl with PKAN, developed bilateral optic atrophy and the appearance of the retina and electroretinography were normal...
June 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/26805007/coa-protects-against-the-deleterious-effects-of-caloric-overload-in-drosophila
#14
Laura Palanker Musselman, Jill L Fink, Thomas J Baranski
We developed a Drosophila model of T2D in which high sugar (HS) feeding leads to insulin resistance. In this model, adipose TG storage is protective against fatty acid toxicity and diabetes. Initial biochemical and gene expression studies suggested that deficiency in CoA might underlie reduced TG synthesis in animals during chronic HS feeding. Focusing on the Drosophila fat body (FB), which is specialized for TG storage and lipolysis, we undertook a series of experiments to test the hypothesis that CoA could protect against the deleterious effects of caloric overload...
March 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/26651582/pantothenic-acid-vitamin-b5-in-infant-formula-and-adult-pediatric-nutritional-formula-by-ultra-high-pressure-liquid-chromatography-tandem-mass-spectrometry-method-collaborative-study-final-action-2012-16
#15
Frederic Martin, Esther Campos-Giménez
In order to determine repeatability and reproducibility of AOAC First Action Method 2012.16 [Pantothenic Acid (Vitamin B5) in Infant Formula and Adult/Pediatric Nutritional Formula by Ultra-High Pressure Liquid Chromatography/Tandem Mass Spectrometry], a collaborative study was organized. The study was divided in two parts: method setup and qualification of participants (part 1) and collaborative study participation (part 2). For part 1, each participating laboratory was asked to analyze two practice samples using the aforementioned method...
November 2015: Journal of AOAC International
https://www.readbyqxmd.com/read/26600677/development-of-an-efficient-in-vitro-plant-regeneration-system-amenable-to-agrobacterium-mediated-transformation-of-a-recalcitrant-grain-legume-blackgram-vigna-mungo-l-hepper
#16
Manish Sainger, Darshna Chaudhary, Savita Dahiya, Ranjana Jaiwal, Pawan K Jaiwal
An efficient, rapid and direct multiple shoot regeneration system amenable to Agrobacterium-mediated transformation from primary leaf with intact petiole of blackgram (Vigna mungo) is established for the first time. The effect of the explant type and its age, type and concentration of cytokinin and auxin either alone or in combination and genotype on multiple shoot regeneration efficiency and frequency was optimized. The primary leaf explants with petiole excised from 4-day-old seedlings directly developed multiple shoots (an average of 10 shoots/ explant) from the cut ends of the petiole in 95 % of the cultures on MSB (MS salts and B5 vitamins) medium containing 1...
October 2015: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/26549575/correction-of-a-genetic-deficiency-in-pantothenate-kinase-1-using-phosphopantothenate-replacement-therapy
#17
Stephen P Zano, Caroline Pate, Matthew Frank, Charles O Rock, Suzanne Jackowski
Coenzyme A (CoA) is a ubiquitous cofactor involved in numerous essential biochemical transformations, and along with its thioesters is a key regulator of intermediary metabolism. Pantothenate (vitamin B5) phosphorylation by pantothenate kinase (PanK) is thought to control the rate of CoA production. Pantothenate kinase associated neurodegeneration is a hereditary disease that arises from mutations that inactivate the human PANK2 gene. Aryl phosphoramidate phosphopantothenate derivatives were prepared to test the feasibility of using phosphopantothenate replacement therapy to bypass the genetic deficiency in the Pank1(-/-) mouse model...
December 2015: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/26476142/knock-down-of-pantothenate-kinase-2-severely-affects-the-development-of-the-nervous-and-vascular-system-in-zebrafish-providing-new-insights-into-pkan-disease
#18
Daniela Zizioli, Natascia Tiso, Adele Guglielmi, Claudia Saraceno, Giorgia Busolin, Roberta Giuliani, Deepak Khatri, Eugenio Monti, Giuseppe Borsani, Francesco Argenton, Dario Finazzi
Pantothenate Kinase Associated Neurodegeneration (PKAN) is an autosomal recessive disorder with mutations in the pantothenate kinase 2 gene (PANK2), encoding an essential enzyme for Coenzyme A (CoA) biosynthesis. The molecular connection between defects in this enzyme and the neurodegenerative phenotype observed in PKAN patients is still poorly understood. We exploited the zebrafish model to study the role played by the pank2 gene during embryonic development and get new insight into PKAN pathogenesis. The zebrafish orthologue of hPANK2 lies on chromosome 13, is a maternal gene expressed in all development stages and, in adult animals, is highly abundant in CNS, dorsal aorta and caudal vein...
January 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/26446907/the-ameliorating-effects-of-vitamin-e-on-hepatic-antioxidant-system-and-xenobiotic-metabolizing-enzymes-in-fenvalerate-exposed-iodine-deficient-rats
#19
Belma Kocer-Gumusel, Pinar Erkekoglu, Aydan Caglayan, Filiz Hincal
This study investigated the effects of vitamin E (VE) on hepatic antioxidant system and drug-metabolizing enzymes in fenvalerate (FEN)-exposed iodine-deficient (ID) Wistar rats. ID was produced by perchlorate containing drinking water. VE was introduced by a loading dose of 100 mg/kg/d, i.g. for the first three days in the last week of feeding period; then with a single maintenance dose of 40 mg/kg on the 4th day. During last week, FEN groups (F) received 100 mg/kg/d, i.p. FEN. VE alone did not significantly affect thyroid hormones and antioxidant parameters; however, significantly increased total cytochrome P450 (38%) and cytochrome b5 levels (36%)...
2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/26403427/vitamin-b5-and-n-acetylcysteine-in-nonalcoholic-steatohepatitis-a-preclinical-study-in-a-dietary-mouse-model
#20
Mariana Verdelho Machado, Leandi Kruger, Mark L Jewell, Gregory Alexander Michelotti, Thiago de Almeida Pereira, Guanhua Xie, Cynthia A Moylan, Anna Mae Diehl
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease and second indication for liver transplantation in the Western world. Effective therapy is still not available. Previously we showed a critical role for caspase-2 in the pathogenesis of nonalcoholic steatohepatitis (NASH), the potentially progressive form of NAFLD. An imbalance between free coenzyme A (CoA) and acyl-CoA ratio is known to induce caspase-2 activation. OBJECTIVES: We aimed to evaluate CoA metabolism and the effects of supplementation with CoA precursors, pantothenate and cysteine, in mouse models of NASH...
January 2016: Digestive Diseases and Sciences
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