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https://www.readbyqxmd.com/read/27903277/sequence-diversity-of-dengue-virus-type-2-in-brain-and-thymus-of-infected-interferon-receptor-ko-mice-implications-for-dengue-virulence
#1
Priya Dhole, Emi E Nakayama, Akatsuki Saito, Kriengsak Limkittikul, Supranee Phanthanawiboon, Tatsuo Shioda, Takeshi Kurosu
BACKGROUND: We previously reported that a clinical isolate of dengue virus (DENV) is capable of causing acute-phase systemic infection in mice harboring knockouts of the genes encoding type-I and -II interferon IFN receptors (IFN-α/β/γR KO mice); in contrast, other virulent DENV isolates exhibited slow disease progression in this mice, yielding lethal infection around 20 days post-infection (p.i.). In the present study, we sought to clarify the dynamics of slow disease progression by examining disease progression of a type-2 DENV clinical isolate (DV2P04/08) in mice...
November 30, 2016: Virology Journal
https://www.readbyqxmd.com/read/27893666/four-weeks-of-paritaprevir-ritonavir-ombitasvir-plus-dasabuvir-encountering-dengue-fever-resulted-in-sustained-virological-response-in-an-hcv-patient-a-case-report
#2
Chung-Feng Huang, Tyng-Yuan Jang, Po-Liang Lu, Ming-Lung Yu
BACKGROUND: Direct antiviral agent (DAA) has been the standard of care for patients with hepatitis C virus (HCV) infection. Twelve weeks of paritaprevir/ritonavir/ombitasvir plus dasabuvir (PROD) with or without ribavirin has shown to have a sustained virological response at post-treatment 12 weeks (SVR12) rate of >90% in HCV genotype 1 (HCV-1) patients. METHODS: We report a HCV-1b patient who received only 25 days of PROD treatment. RESULTS: The patient early terminated treatment due to dengue fever but eventually achieved SVR12...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27886660/evaluation-of-the-safety-and-adjuvant-effect-of-a-detoxified-listeriolysin-o-mutant-on-the-humoral-response-to-dengue-virus-antigens
#3
K G Hernández-Flores, A L Calderón-Garcidueñas, G Mellado-Sánchez, R Ruiz-Ramos, L A Sánchez-Vargas, P Thomas-Dupont, I Y Izaguirre-Hernández, J Téllez-Sosa, J Martínez-Barnetche, L Wood, Y Paterson, L Cedillo-Barrón, O López-Franco, H Vivanco-Cid
Listeriolysin O (LLO) has been proposed as a potential carrier or adjuvant molecule in the vaccination field. However, the cytotoxic and pro-apoptotic effects of LLO are the major limitations for this purpose. Here, we have performed a preclinical safety evaluation and characterized a new potential adjuvant application for a non-cytolytic LLO mutant (dtLLO) to enhance and modulate the immune response against the envelope (E) protein from Dengue virus. In addition, we have studied the adjuvant effects of dtLLO on human immune cells and the role of membrane cholesterol for the binding and the pro-inflammatory property of the toxoid...
November 25, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27832191/dengue-virus-infection-is-through-a-cooperative-interaction-between-a-mannose-receptor-and-clec5a-on-macrophage-as-a-multivalent-hetero-complex
#4
Yen-Lung Lo, Gunn-Guang Liou, Jia-Huei Lyu, Michael Hsiao, Tsui-Ling Hsu, Chi-Huey Wong
Dengue fever is a mosquito-borne viral pandemic disease that is widespread in the tropical and subtropical areas. Dengue virus uses human mannose-binding receptor (MR) and DC-SIGN on macrophages as primary receptors, and CLEC5A as signaling receptor to sense the dengue virus invasion and then to signal and stimulate macrophages to secrete cytokines. But the interplay between MR/DC-SIGN and CLEC5A is unknown. Here we demonstrate a plausible mechanism for the interaction, i.e. MR/DC-SIGN first attracts the virus with high avidity, and the virus concurrently interacts with CLEC5A in close proximity to form a multivalent hetero-complex and facilitate CLEC5A-mediated signal transduction...
2016: PloS One
https://www.readbyqxmd.com/read/27608777/predicting-survival-in-ards
#5
EDITORIAL
Niteen D Karnik, Anish V Gupta
Acute respiratory distress syndrome (ARDS) is a fulminant clinical disorder of varied etiology, characterized by diffuse lung injury and severe hypoxemia. It is a leading cause of ICU admission and the associated high mortality has sparked a lot of research on etiology, outcome, scoring systems, mortality predictors, biomarkers including inflammatory cytokines and even genomics in ARDS. The previously used AECC (American European Consensus Conference) definition (1994) of ARDS was replaced by the recent Berlin definition (2012) so as to improve its validity and reliability...
November 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27456172/dengue-virus-infection-induces-interferon-lambda1-to-facilitate-cell-migration
#6
Yu-Lin Hsu, Mei-Yi Wang, Ling-Jun Ho, Jenn-Haung Lai
A marked increase in the rate of dengue virus (DENV) infection has resulted in more than 212 deaths in Taiwan since the beginning of 2015, mostly from fatal outcomes such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms of these fatal manifestations are poorly understood. Cytokines induce an overwhelming immune reaction and thus have crucial roles. Interferon-lambda (IFN-λ), a newly identified IFN subtype, has antiviral effects, but its immunologic effects in DENV infection have not been investigated...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27115486/diseases-neglected-by-the-media-in-esp%C3%A3-rito-santo-brazil-in-2011-2012
#7
Aline Guio Cavaca, Tatiana Breder Emerich, Paulo Roberto Vasconcellos-Silva, Edson Theodoro dos Santos-Neto, Adauto Emmerich Oliveira
BACKGROUND: The aims of the present study were to identify and analyse the Diseases Neglected by the Media (DNMs) via a comparison between the most important health issues to the population of Espírito Santo, Brazil, from the epidemiological perspective (health value) and their effective coverage by the print media, and to analyse the DNMs considering the perspective of key journalists involved in the dissemination of health topics in the state media. METHODOLOGY: Morbidity and mortality data were collected from official documents and from Health Information Systems...
April 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26919942/concurrent-infections-of-dengue-viruses-serotype-2-and-3-in-patient-with-severe-dengue-from-jakarta-indonesia
#8
Soroy Lardo, Yaldiera Utami, Benediktus Yohan, Seri Mmu Tarigan, Widayat Djoko Santoso, Leonard Nainggolan, R Tedjo Sasmono
OBJECTIVE: To describe the clinical manifestation of patient with severe dengue, to identify the serotypes and genotypes of dengue viruses (DENV) which concurrently infecting the patient, and to explore the possible relationship of severe dengue with the concurrent infection of DENV. METHODS: Dengue diagnosis was performed using NS1 antigen detection and IgG/IgM ELISA. Standard clinical and laboratory examinations were performed to obtain the clinical and hematological data...
February 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/26911940/-experience-of-integrated-traditional-chinese-and-western-medicine-in-first-case-of-imported-zika-virus-disease-in-china
#9
Yichu Deng, Liping Zeng, Wen Bao, Pinghua Xu, Gongrong Zhong
OBJECTIVE: Zika virus disease is an acute infectious disease caused by Zika virus transmitted through Aedes mosquitoes. To explore the therapeutic effect of integrated traditional Chinese and Western Medicine for Zika virus disease, the treatment process of the first imported case in China was reviewed. METHODS: The first imported Zika virus disease in China was admitted to Ganxian People's Hospital in Jiangxi Province on February 6th, 2016, and the patient received isolation treatment for 9 days and cured later...
February 2016: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/26542647/inhibition-of-dengue-virus-production-and-cytokine-chemokine-expression-by-ribavirin-and-compound-a
#10
Thidarath Rattanaburee, Mutita Junking, Aussara Panya, Nunghathai Sawasdee, Pucharee Songprakhon, Aroonroong Suttitheptumrong, Thawornchai Limjindaporn, Guy Haegeman, Pa-thai Yenchitsomanus
Dengue virus (DENV) infection is a worldwide public health problem with an increasing magnitude. The severity of disease in the patients with DENV infection correlates with high viral load and massive cytokine production - the condition referred to as "cytokine storm". Thus, concurrent inhibition of DENV and cytokine production should be more effective for treatment of DENV infection. In this study, we investigated the effects of the antiviral agent - ribavirin (RV), and the anti-inflammatory compound - compound A (CpdA), individually or in combination, on DENV production and cytokine/chemokine transcription in human lung epithelial carcinoma (A549) cells infected with DENV...
December 2015: Antiviral Research
https://www.readbyqxmd.com/read/26350772/dengue-virus-infection-induces-formation-of-g3bp1-granules-in-human-lung-epithelial-cells
#11
Jun Xia, Xiaoyan Chen, Feng Xu, Yi Wang, Yongxia Shi, Yuye Li, Junfang He, Ping Zhang
Cells reprogram ongoing translation in response to viral infection, resulting in formation of stress granules (SGs), while viruses have evolved a variety of strategies to antagonize the host SG response. Previous literature reported that in BHK-1 cells, infection with dengue virus (DENV) interfered with the SG formation. In the current study, we further investigated SG formation in human epithelial A549 cells by detecting subcellular localization of two SG hallmarks, TIA-1 and G3BP1. In response to DENV type 2 (DENV2) and type 3 (DENV3) infection, G3BP1, but not TIA-1, was recruited into cytoplasmic granules in some cells, and viral protein synthesis was significantly impaired in the G3BP1-granule-containing cells...
December 2015: Archives of Virology
https://www.readbyqxmd.com/read/26304914/cavity-forming-pneumonia-due-to-staphylococcus-aureus-following-dengue-fever
#12
Nobuyuki Miyata, Yukihiro Yoshimura, Natsuo Tachikawa, Yuichiro Amano, Yohei Sakamoto, Youko Kosuge
While visiting Malaysia, a 22-year-old previously healthy Japanese man developed myalgia, headache, and fever, leading to a diagnosis of classical dengue fever. After improvement and returning to Japan after a five day hospitalization, he developed productive cough several days after defervescing from dengue. Computed tomography (CT) thorax scan showed multiple lung cavities. A sputum smear revealed leukocytes with phagocytized gram-positive cocci in clusters, and grew an isolate Staphylococcus aureus sensitive to semi-synthetic penicillin; he was treated successfully with ceftriaxone and cephalexin...
November 2015: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/26072955/fatal-invasive-aspergillosis-a-rare-co-infection-with-an-unexpected-image-presentation-in-a-patient-with-dengue-shock-syndrome
#13
Hui-Ching Wang, Ko Chang, Po-Liang Lu, Kun-Bow Tsai, Huang-Chi Chen
INTRODUCTION: Pulmonary infiltration and pleural effusion caused by permeability syndrome are the hallmark of pulmonary manifestation of dengue cases. OBJECTIVE AND METHODS: We report a 95-year-old chronic obstructive pulmonary disease case having dengue shock syndrome. Chest X-ray examination revealed diffuse lung infiltration. However, bilateral pneumotoceles were unexpectedly found in computed tomography (CT) images. Dengue virus type 2 infection was confirmed by virus culture, serology and reverse transcriptase-polymerase chain reaction...
June 15, 2015: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26018150/sequence-specific-modifications-enhance-the-broad-spectrum-antiviral-response-activated-by-rig-i-agonists
#14
Cindy Chiang, Vladimir Beljanski, Kevin Yin, David Olagnier, Fethia Ben Yebdri, Courtney Steel, Marie-Line Goulet, Victor R DeFilippis, Daniel N Streblow, Elias K Haddad, Lydie Trautmann, Ted Ross, Rongtuan Lin, John Hiscott
UNLABELLED: The cytosolic RIG-I (retinoic acid-inducible gene I) receptor plays a pivotal role in the initiation of the immune response against RNA virus infection by recognizing short 5'-triphosphate (5'ppp)-containing viral RNA and activating the host antiviral innate response. In the present study, we generated novel 5'ppp RIG-I agonists of varieous lengths, structures, and sequences and evaluated the generation of the antiviral and inflammatory responses in human epithelial A549 cells, human innate immune primary cells, and murine models of influenza and chikungunya viral pathogenesis...
August 2015: Journal of Virology
https://www.readbyqxmd.com/read/25866185/eukaryotic-initiation-factor-4ai-interacts-with-ns4a-of-dengue-virus-and-plays-an-antiviral-role
#15
Xiaoyan Chen, Jun Xia, Qirui Zhao, Yi Wang, Jingyu Liu, Lianqiang Feng, Junfang He, Ping Zhang
Dengue virus (DENV) is a mosquito-borne flavivirus that causes the most prevalent diseases in tropical and subtropical regions. DENV utilizes host factors to facilitate its replication, while host cells intend to restrain virus replication. NS4A of DENV has been implicated to play a crucial role during viral replication. To identify more cellular proteins that are recruited by NS4A, we carried out a tandem affinity purification assay. The mass spectrometry data revealed that human eukaryotic initiation factor 4AI (eIF4AI) was one of potential NS4A-interacting partners...
May 22, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/25802128/-disseminated-histoplamosis-in-adolescent-mimicking-granulomatosis-with-polyangiitis
#16
Marlon van Weelden, Gabriela R Viola, Katia T Kozu, Nadia E Aikawa, Claudia M Ivo, Clovis A Silva
INTRODUCTION: Systemic histoplasmosis is an invasive fungal infection that may mimic primary vasculitis, particularly granulomatosis with polyangiitis (GPA), and was rarely described in adult patients. We reported an immunocompetent patient with disseminated histoplasmosis mimicking GPA who fulfilled European League Against Rheumatism (EULAR)/Pediatric Rheumatology International Trials Organisation (PRINTO)/Pediatric Rheumatology European Society (PRES) validated classification criteria...
March 4, 2015: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/25792165/neuropsychiatric-manifestations-of-some-tropical-diseases
#17
REVIEW
Joanna M Moryś, Maria Jeżewska, Krzysztof Korzeniewski
Some tropical diseases are the direct cause of severe disturbances of cerebral function while others affect only finer cerebral systems controlling fears, anxiety and personality traits. The mechanisms by which psychiatric symptoms are produced in tropical disorders are not any different from the mechanisms that relate to any physical disorders. Neuropsychiatric symptoms may be caused by a number of different mechanisms including bacterial toxins, release of cytokines, hyperthermia, shock (poor perfusion), acute renal insufficiency, pulmonary failure (shock lung), coagulopathy, disruption of the blood-brain barrier, and/or the nest of pathogens into the central nervous system...
2015: International Maritime Health
https://www.readbyqxmd.com/read/25302582/a-probabilistic-spatial-dengue-fever-risk-assessment-by-a-threshold-based-quantile-regression-method
#18
Chuan-Hung Chiu, Tzai-Hung Wen, Lung-Chang Chien, Hwa-Lung Yu
Understanding the spatial characteristics of dengue fever (DF) incidences is crucial for governmental agencies to implement effective disease control strategies. We investigated the associations between environmental and socioeconomic factors and DF geographic distribution, are proposed a probabilistic risk assessment approach that uses threshold-based quantile regression to identify the significant risk factors for DF transmission and estimate the spatial distribution of DF risk regarding full probability distributions...
2014: PloS One
https://www.readbyqxmd.com/read/25290923/-travel-associated-pneumonias
#19
REVIEW
H F Geerdes-Fenge
Respiratory infections are responsible for up to 11% of febrile infections in travellers or immigrants from tropical and subtropical regions. The main pathogens are the same as in temperate climate zones: Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, influenza viruses, Legionella pneumophila. However, some pulmonary diseases can be attributed to bacterial, parasitic, viral or fungal pathogens that are endemic in tropical and subtropical regions. The most commonly imported infections are malaria, dengue, and tuberculosis...
October 2014: Pneumologie
https://www.readbyqxmd.com/read/25161356/acute-lung-injury-after-platelet-transfusion-in-a-patient-with-dengue-fever
#20
Ritu Karoli, Sanjay Bhat, Jalees Fatima, Pankaj Verma
Transfusion-related acute lung injury (TRALI) is a serious clinical syndrome associated with the transfusion of plasmacontaining blood components. Recently, TRALI has come to be recognized as the leading cause of transfusion-related mortality. This complication typically presents as shortness of breath, hypoxemia, hypotension, fever, and non cardiogenic pulmonary edema, occurring within 6 h after transfusion. Although the mechanism of TRALI has not been exactly known, it has been associated with human leukocyte antigen antibodies and with biologically active mediators in stored cellular blood components...
July 2014: Asian Journal of Transfusion Science
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