keyword
MENU ▼
Read by QxMD icon Read
search

dengue lung

keyword
https://www.readbyqxmd.com/read/28031839/a-massive-pleural-based-desmoid-tumour
#1
Talha Mahmud, Guness Mal, Farhan Ahmed Majeed, Siaw Ming Chai, Y C Gary Lee
A 49-year-old Pakistani male presented with "heaviness" in his chest. Chest radiograph and computed tomography (CT) confirmed a massive left-sided pleural-based opacity. Three years ago, he was investigated for a left-sided lymphocytic, exudative pleural effusion following an episode of dengue fever. Tube thoracostomy removed 1.3 L of fluid. Pleural biopsy and bronchial washings were non-contributory. He received empirical anti-tuberculosis treatment and remained asymptomatic until this presentation. To investigate the new pleural mass, he underwent a video-assisted thoracoscopic surgery, which revealed a 2...
January 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28006034/peripheral-organs-of-dengue-fatal-cases-present-strong-pro-inflammatory-response-with-participation-of-ifn-gamma-tnf-alpha-and-rantes-producing-cells
#2
Tiago F Póvoa, Edson R A Oliveira, Carlos A Basílio-de-Oliveira, Gerard J Nuovo, Vera L A Chagas, Natália G Salomão, Ester M Mota, Marciano V Paes
Dengue disease is an acute viral illness caused by dengue virus (DENV) that can progress to hemorrhagic stages leading to about 20000 deaths every year worldwide. Despite many clinical investigations regarding dengue, the immunopathogenic process by which infected patients evolve to the severe forms is not fully understood. Apart from differences in virulence and the antibody cross reactivity that can potentially augment virus replication, imbalanced cellular immunity is also seen as a major concern in the establishment of severe dengue...
2016: PloS One
https://www.readbyqxmd.com/read/27995614/influenza-and-dengue-virus-co-infection-impairs-monocyte-recruitment-to-the-lung-increases-dengue-virus-titers-and-exacerbates-pneumonia
#3
Michael A Schmid, Karla N González, Sanjana Shah, José Peña, Matthias Mack, Laura B Talarico, Fernando P Polack, Eva Harris
Co-infections of influenza virus and bacteria are known to cause severe disease, but little information exists on co-infections with other acute viruses. Seasonal influenza and dengue viruses (DENV) regularly co-circulate in tropical regions. The pandemic spread of influenza virus H1N1 (hereafter H1N1) in 2009 led to additional severe disease cases that were co-infected with DENV. Here, we investigated the impact of co-infection on immune responses and pathogenesis in a new mouse model. Co-infection of otherwise sublethal doses of a Nicaraguan clinical H1N1 isolate and two days later with a virulent DENV2 strain increased systemic DENV titers and caused 90% lethality...
December 20, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27974556/rplp1-and-rplp2-are-essential-flavivirus-host-factors-that-promote-early-viral-protein-accumulation
#4
Rafael K Campos, Benjamin Wong, Xuping Xie, Yi-Fan Lu, Pei-Yong Shi, Julien Pompon, Mariano A Garcia-Blanco, Shelton S Bradrick
: The Flavivirus genus contains several arthropod-borne viruses that pose global health threats, including dengue viruses (DENV), yellow fever virus (YFV) and Zika virus (ZIKV). In order to understand how these viruses replicate in human cells, we previously conducted genome-scale RNAi screens to identify candidate host factors. In these screens we identified ribosomal proteins RPLP1 and RPLP2 (RPLP1/2) to be among the most crucial putative host factors required for DENV and YFV infection...
December 14, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27903277/sequence-diversity-of-dengue-virus-type-2-in-brain-and-thymus-of-infected-interferon-receptor-ko-mice-implications-for-dengue-virulence
#5
Priya Dhole, Emi E Nakayama, Akatsuki Saito, Kriengsak Limkittikul, Supranee Phanthanawiboon, Tatsuo Shioda, Takeshi Kurosu
BACKGROUND: We previously reported that a clinical isolate of dengue virus (DENV) is capable of causing acute-phase systemic infection in mice harboring knockouts of the genes encoding type-I and -II interferon IFN receptors (IFN-α/β/γR KO mice); in contrast, other virulent DENV isolates exhibited slow disease progression in this mice, yielding lethal infection around 20 days post-infection (p.i.). In the present study, we sought to clarify the dynamics of slow disease progression by examining disease progression of a type-2 DENV clinical isolate (DV2P04/08) in mice...
November 30, 2016: Virology Journal
https://www.readbyqxmd.com/read/27893666/four-weeks-of-paritaprevir-ritonavir-ombitasvir-plus-dasabuvir-encountering-dengue-fever-resulted-in-sustained-virological-response-in-an-hcv-patient-a-case-report
#6
Chung-Feng Huang, Tyng-Yuan Jang, Po-Liang Lu, Ming-Lung Yu
BACKGROUND: Direct antiviral agent (DAA) has been the standard of care for patients with hepatitis C virus (HCV) infection. Twelve weeks of paritaprevir/ritonavir/ombitasvir plus dasabuvir (PROD) with or without ribavirin has shown to have a sustained virological response at post-treatment 12 weeks (SVR12) rate of >90% in HCV genotype 1 (HCV-1) patients. METHODS: We report a HCV-1b patient who received only 25 days of PROD treatment. RESULTS: The patient early terminated treatment due to dengue fever but eventually achieved SVR12...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27886660/evaluation-of-the-safety-and-adjuvant-effect-of-a-detoxified-listeriolysin-o-mutant-on-the-humoral-response-to-dengue-virus-antigens
#7
K G Hernández-Flores, A L Calderón-Garcidueñas, G Mellado-Sánchez, R Ruiz-Ramos, L A Sánchez-Vargas, P Thomas-Dupont, I Y Izaguirre-Hernández, J Téllez-Sosa, J Martínez-Barnetche, L Wood, Y Paterson, L Cedillo-Barrón, O López-Franco, H Vivanco-Cid
Listeriolysin O (LLO) has been proposed as a potential carrier or adjuvant molecule in the vaccination field. However, the cytotoxic and pro-apoptotic effects of LLO are the major limitations for this purpose. Here, we have performed a preclinical safety evaluation and characterized a new potential adjuvant application for a non-cytolytic LLO mutant (dtLLO) to enhance and modulate the immune response against the envelope (E) protein from Dengue virus. In addition, we have studied the adjuvant effects of dtLLO on human immune cells and the role of membrane cholesterol for the binding and the pro-inflammatory property of the toxoid...
November 25, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27832191/dengue-virus-infection-is-through-a-cooperative-interaction-between-a-mannose-receptor-and-clec5a-on-macrophage-as-a-multivalent-hetero-complex
#8
Yen-Lung Lo, Gunn-Guang Liou, Jia-Huei Lyu, Michael Hsiao, Tsui-Ling Hsu, Chi-Huey Wong
Dengue fever is a mosquito-borne viral pandemic disease that is widespread in the tropical and subtropical areas. Dengue virus uses human mannose-binding receptor (MR) and DC-SIGN on macrophages as primary receptors, and CLEC5A as signaling receptor to sense the dengue virus invasion and then to signal and stimulate macrophages to secrete cytokines. But the interplay between MR/DC-SIGN and CLEC5A is unknown. Here we demonstrate a plausible mechanism for the interaction, i.e. MR/DC-SIGN first attracts the virus with high avidity, and the virus concurrently interacts with CLEC5A in close proximity to form a multivalent hetero-complex and facilitate CLEC5A-mediated signal transduction...
2016: PloS One
https://www.readbyqxmd.com/read/27608777/predicting-survival-in-ards
#9
EDITORIAL
Niteen D Karnik, Anish V Gupta
Acute respiratory distress syndrome (ARDS) is a fulminant clinical disorder of varied etiology, characterized by diffuse lung injury and severe hypoxemia. It is a leading cause of ICU admission and the associated high mortality has sparked a lot of research on etiology, outcome, scoring systems, mortality predictors, biomarkers including inflammatory cytokines and even genomics in ARDS. The previously used AECC (American European Consensus Conference) definition (1994) of ARDS was replaced by the recent Berlin definition (2012) so as to improve its validity and reliability...
November 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27456172/dengue-virus-infection-induces-interferon-lambda1-to-facilitate-cell-migration
#10
Yu-Lin Hsu, Mei-Yi Wang, Ling-Jun Ho, Jenn-Haung Lai
A marked increase in the rate of dengue virus (DENV) infection has resulted in more than 212 deaths in Taiwan since the beginning of 2015, mostly from fatal outcomes such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms of these fatal manifestations are poorly understood. Cytokines induce an overwhelming immune reaction and thus have crucial roles. Interferon-lambda (IFN-λ), a newly identified IFN subtype, has antiviral effects, but its immunologic effects in DENV infection have not been investigated...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27115486/diseases-neglected-by-the-media-in-esp%C3%A3-rito-santo-brazil-in-2011-2012
#11
Aline Guio Cavaca, Tatiana Breder Emerich, Paulo Roberto Vasconcellos-Silva, Edson Theodoro dos Santos-Neto, Adauto Emmerich Oliveira
BACKGROUND: The aims of the present study were to identify and analyse the Diseases Neglected by the Media (DNMs) via a comparison between the most important health issues to the population of Espírito Santo, Brazil, from the epidemiological perspective (health value) and their effective coverage by the print media, and to analyse the DNMs considering the perspective of key journalists involved in the dissemination of health topics in the state media. METHODOLOGY: Morbidity and mortality data were collected from official documents and from Health Information Systems...
April 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26919942/concurrent-infections-of-dengue-viruses-serotype-2-and-3-in-patient-with-severe-dengue-from-jakarta-indonesia
#12
Soroy Lardo, Yaldiera Utami, Benediktus Yohan, Seri Mmu Tarigan, Widayat Djoko Santoso, Leonard Nainggolan, R Tedjo Sasmono
OBJECTIVE: To describe the clinical manifestation of patient with severe dengue, to identify the serotypes and genotypes of dengue viruses (DENV) which concurrently infecting the patient, and to explore the possible relationship of severe dengue with the concurrent infection of DENV. METHODS: Dengue diagnosis was performed using NS1 antigen detection and IgG/IgM ELISA. Standard clinical and laboratory examinations were performed to obtain the clinical and hematological data...
February 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/26911940/-experience-of-integrated-traditional-chinese-and-western-medicine-in-first-case-of-imported-zika-virus-disease-in-china
#13
Yichu Deng, Liping Zeng, Wen Bao, Pinghua Xu, Gongrong Zhong
OBJECTIVE: Zika virus disease is an acute infectious disease caused by Zika virus transmitted through Aedes mosquitoes. To explore the therapeutic effect of integrated traditional Chinese and Western Medicine for Zika virus disease, the treatment process of the first imported case in China was reviewed. METHODS: The first imported Zika virus disease in China was admitted to Ganxian People's Hospital in Jiangxi Province on February 6th, 2016, and the patient received isolation treatment for 9 days and cured later...
February 2016: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/26542647/inhibition-of-dengue-virus-production-and-cytokine-chemokine-expression-by-ribavirin-and-compound-a
#14
Thidarath Rattanaburee, Mutita Junking, Aussara Panya, Nunghathai Sawasdee, Pucharee Songprakhon, Aroonroong Suttitheptumrong, Thawornchai Limjindaporn, Guy Haegeman, Pa-thai Yenchitsomanus
Dengue virus (DENV) infection is a worldwide public health problem with an increasing magnitude. The severity of disease in the patients with DENV infection correlates with high viral load and massive cytokine production - the condition referred to as "cytokine storm". Thus, concurrent inhibition of DENV and cytokine production should be more effective for treatment of DENV infection. In this study, we investigated the effects of the antiviral agent - ribavirin (RV), and the anti-inflammatory compound - compound A (CpdA), individually or in combination, on DENV production and cytokine/chemokine transcription in human lung epithelial carcinoma (A549) cells infected with DENV...
December 2015: Antiviral Research
https://www.readbyqxmd.com/read/26350772/dengue-virus-infection-induces-formation-of-g3bp1-granules-in-human-lung-epithelial-cells
#15
Jun Xia, Xiaoyan Chen, Feng Xu, Yi Wang, Yongxia Shi, Yuye Li, Junfang He, Ping Zhang
Cells reprogram ongoing translation in response to viral infection, resulting in formation of stress granules (SGs), while viruses have evolved a variety of strategies to antagonize the host SG response. Previous literature reported that in BHK-1 cells, infection with dengue virus (DENV) interfered with the SG formation. In the current study, we further investigated SG formation in human epithelial A549 cells by detecting subcellular localization of two SG hallmarks, TIA-1 and G3BP1. In response to DENV type 2 (DENV2) and type 3 (DENV3) infection, G3BP1, but not TIA-1, was recruited into cytoplasmic granules in some cells, and viral protein synthesis was significantly impaired in the G3BP1-granule-containing cells...
December 2015: Archives of Virology
https://www.readbyqxmd.com/read/26304914/cavity-forming-pneumonia-due-to-staphylococcus-aureus-following-dengue-fever
#16
Nobuyuki Miyata, Yukihiro Yoshimura, Natsuo Tachikawa, Yuichiro Amano, Yohei Sakamoto, Youko Kosuge
While visiting Malaysia, a 22-year-old previously healthy Japanese man developed myalgia, headache, and fever, leading to a diagnosis of classical dengue fever. After improvement and returning to Japan after a five day hospitalization, he developed productive cough several days after defervescing from dengue. Computed tomography (CT) thorax scan showed multiple lung cavities. A sputum smear revealed leukocytes with phagocytized gram-positive cocci in clusters, and grew an isolate Staphylococcus aureus sensitive to semi-synthetic penicillin; he was treated successfully with ceftriaxone and cephalexin...
November 2015: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/26072955/fatal-invasive-aspergillosis-a-rare-co-infection-with-an-unexpected-image-presentation-in-a-patient-with-dengue-shock-syndrome
#17
Hui-Ching Wang, Ko Chang, Po-Liang Lu, Kun-Bow Tsai, Huang-Chi Chen
INTRODUCTION: Pulmonary infiltration and pleural effusion caused by permeability syndrome are the hallmark of pulmonary manifestation of dengue cases. OBJECTIVE AND METHODS: We report a 95-year-old chronic obstructive pulmonary disease case having dengue shock syndrome. Chest X-ray examination revealed diffuse lung infiltration. However, bilateral pneumotoceles were unexpectedly found in computed tomography (CT) images. Dengue virus type 2 infection was confirmed by virus culture, serology and reverse transcriptase-polymerase chain reaction...
June 15, 2015: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26018150/sequence-specific-modifications-enhance-the-broad-spectrum-antiviral-response-activated-by-rig-i-agonists
#18
Cindy Chiang, Vladimir Beljanski, Kevin Yin, David Olagnier, Fethia Ben Yebdri, Courtney Steel, Marie-Line Goulet, Victor R DeFilippis, Daniel N Streblow, Elias K Haddad, Lydie Trautmann, Ted Ross, Rongtuan Lin, John Hiscott
UNLABELLED: The cytosolic RIG-I (retinoic acid-inducible gene I) receptor plays a pivotal role in the initiation of the immune response against RNA virus infection by recognizing short 5'-triphosphate (5'ppp)-containing viral RNA and activating the host antiviral innate response. In the present study, we generated novel 5'ppp RIG-I agonists of varieous lengths, structures, and sequences and evaluated the generation of the antiviral and inflammatory responses in human epithelial A549 cells, human innate immune primary cells, and murine models of influenza and chikungunya viral pathogenesis...
August 2015: Journal of Virology
https://www.readbyqxmd.com/read/25866185/eukaryotic-initiation-factor-4ai-interacts-with-ns4a-of-dengue-virus-and-plays-an-antiviral-role
#19
Xiaoyan Chen, Jun Xia, Qirui Zhao, Yi Wang, Jingyu Liu, Lianqiang Feng, Junfang He, Ping Zhang
Dengue virus (DENV) is a mosquito-borne flavivirus that causes the most prevalent diseases in tropical and subtropical regions. DENV utilizes host factors to facilitate its replication, while host cells intend to restrain virus replication. NS4A of DENV has been implicated to play a crucial role during viral replication. To identify more cellular proteins that are recruited by NS4A, we carried out a tandem affinity purification assay. The mass spectrometry data revealed that human eukaryotic initiation factor 4AI (eIF4AI) was one of potential NS4A-interacting partners...
May 22, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/25802128/-disseminated-histoplamosis-in-adolescent-mimicking-granulomatosis-with-polyangiitis
#20
Marlon van Weelden, Gabriela R Viola, Katia T Kozu, Nadia E Aikawa, Claudia M Ivo, Clovis A Silva
INTRODUCTION: Systemic histoplasmosis is an invasive fungal infection that may mimic primary vasculitis, particularly granulomatosis with polyangiitis (GPA), and was rarely described in adult patients. We reported an immunocompetent patient with disseminated histoplasmosis mimicking GPA who fulfilled European League Against Rheumatism (EULAR)/Pediatric Rheumatology International Trials Organisation (PRINTO)/Pediatric Rheumatology European Society (PRES) validated classification criteria...
March 4, 2015: Revista Brasileira de Reumatologia
keyword
keyword
77005
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"