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Depression and pain and manipulation

Sohita Dhillon
Hydrocodone bitartrate extended-release (Hysingla(®) ER; referred to hereafter as hydrocodone ER) was the first single-entity hydrocodone formulation recognized by the US FDA as having abuse-deterrent properties. It is indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Once-daily oral hydrocodone ER provides consistent plasma hydrocodone concentrations and sustained analgesia over the 24-h dosing interval...
November 2016: Clinical Drug Investigation
Victoria J Madden, Leslie N Russek, Daniel S Harvie, Johan W S Vlaeyen, G Lorimer Moseley
OBJECTIVE : Associative learning has been proposed as a mechanism behind the persistence of pain after tissue healing. The simultaneous occurrence of nociceptive and non-nociceptive input during acute injury mimics the pairings thought to drive classical conditioning effects. However, empirical evidence for classically conditioned allodynia is lacking. We aimed to manipulate pain thresholds with a classical conditioning procedure that used non-nociceptive somatosensory stimuli as conditioned stimuli (CS) and nociceptive stimuli as unconditioned stimuli...
September 28, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Neil C Lax, Kh Tanvir Ahmed, Christopher M Ignatz, Carmenza Spadafora, Benedict J Kolber, Kevin J Tidgewell
CONTEXT: Marine cyanobacteria offer a robust resource for natural products drug discovery due to the secondary metabolites they produce. OBJECTIVE: To identify novel cyanobacterial compounds that exhibit CNS psychoactive effects. MATERIALS AND METHODS: Cyanobacteria were collected from Las Perlas Archipelago, Panama and subjected to dichloromethane/methanol extraction and fractionation by column chromatography before being screened for affinity against a panel of CNS targets...
May 14, 2016: Pharmaceutical Biology
Marco Annoni, Franklin G Miller
In this article we explore the ethics of manipulating verbal information for the sake of influencing health outcomes through placebo and nocebo responses. Recent scientific research on placebo and nocebo effects has drawn attention to the ways in which communication by health professionals may modulate the symptoms of patients across an array of highly prevalent conditions such as pain, depression, anxiety, insomnia, irritable bowel syndrome, migraine, and Parkinson's disease. The positive and negative effects of clinicians' communication on patient outcomes pose important ethical issues, which we describe in this article under the label of "the ethics of therapeutic communication" (TC)...
March 2016: Kennedy Institute of Ethics Journal
John C Licciardone, Robert J Gatchel, Subhash Aryal
CONTEXT: Little is known about recovery after spinal manipulation in patients with low back pain (LBP). OBJECTIVE: To assess recovery from chronic LBP after a short regimen of osteopathic manipulative treatment (OMT) in a responder analysis of the OSTEOPAThic Health outcomes In Chronic low back pain (OSTEOPATHIC) Trial. METHODS: A randomized double-blind, sham-controlled trial was conducted to determine the efficacy of 6 OMT sessions over 8 weeks...
March 2016: Journal of the American Osteopathic Association
Shumei Xu, Ying Xue
Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethnic groups. Obesity increases the risk of heart diseases in children and adults. Childhood obesity predisposes the individual to insulin resistance and type 2 diabetes, hypertension, hyperlipidemia, liver and kidney diseases and causes reproductive dysfunction in adults...
January 2016: Experimental and Therapeutic Medicine
M John Petrozzi, Andrew Leaver, Mairwen K Jones, Paulo H Ferreira, Sidney M Rubinstein, Martin G Mackey
BACKGROUND: Various interventions are available for the treatment of chronic low back pain (LBP), including Manual Therapy and Cognitive Behavioural Therapy (CBT). The purpose of this study is to evaluate whether the addition of an internet-based CBT program leads to better outcomes in patients who are treated with multimodal manual therapy for chronic LBP. METHODS/DESIGN: A randomized controlled trial comparing a combined intervention, consisting of internet-based CBT utilising MoodGYM plus multimodal manual therapy, to multimodal manual therapy alone for patients with chronic LBP...
2015: Chiropractic & Manual Therapies
Emily Warner, Rebecca Krivitsky, Katherine Cone, Phillip Atherton, Travis Pitre, Janell Lanpher, Denise Giuvelis, Ivy Bergquist, Tamara King, Edward J Bilsky, Glenn W Stevenson
There has been recent interest in characterizing the effects of pain-like states on motivated behaviors in order to quantify how pain modulates goal-directed behavior and the persistence of that behavior. The current set of experiments assessed the effects of an incisional postoperative pain manipulation on food-maintained responding under a progressive-ratio (PR) operant schedule. Independent variables included injury state (plantar incision or anesthesia control) and reinforcer type (grain pellet or sugar pellet); dependent variables were tactile sensory thresholds and response breakpoint...
December 2015: Drug Development Research
S Stevens Negus, Bradley Neddenriep, Ahmad A Altarifi, F Ivy Carroll, Michael D Leitl, Laurence L Miller
Pain-related functional impairment and behavioral depression are diagnostic indicators of pain and targets for its treatment. Nesting is an innate behavior in mice that may be sensitive to pain manipulations and responsive to analgesics. The goal of this study was to develop and validate a procedure for evaluation of pain-related depression of nesting in mice. Male ICR mice were individually housed and tested in their home cages. On test days, a 5- × 5-cm Nestlet was subdivided into 6 pieces, the pieces were evenly distributed on the cage floor, and Nestlet consolidation was quantified during 100-minute sessions...
June 2015: Pain
Dorit Gamus
This article assesses the evidence for effectiveness, adverse effects and cost-effectiveness of complementary therapies, as reflected in publications in high impact factor medical journals during the years 2012-2014. The search detected 13 randomized controlled studies (RCTs) and 14 meta-analyses, which collectively assessed results of 191 RCTs involving the participation of several thousand patients. Pain was the major focus of acupuncture research in both clinical and fMRI studies, which demonstrated that the effect of acupuncture is beyond the placebo effect...
January 2015: Harefuah
Ibrahim M Moustafa, Aliaa A Diab
The aim of this study was to investigate the immediate and long-term effects of a one-year multimodal program, with the addition of upper cervical manipulative therapy, on fibromyalgia management outcomes in addition to three-dimensional (3D) postural measures. This randomized clinical trial with one-year follow-up was completed at the research laboratory of our university. A total of 120 (52 female) patients with fibromyalgia syndrome (FMS) and definite C1-2 joint dysfunction were randomly assigned to the control or an experimental group...
July 2015: Rheumatology International
Rajendrakumar C Patel, Hemant Goyal, Ahmed I Shah, Jalal K Ghali
INTRODUCTION: Postpericardiotomy syndrome (PPS) is an inflammatory process, affecting 15% to 20% of patients, after surgery involving pleura, pericardium, or both. The role of electrocardiogram (ECG) in diagnosing PPS is uncertain because ECG is rarely normal (especially after cardiac surgery). We report a case of PPS that presented initially with localized ST-segment elevation and also discuss proposed mechanisms. CLINICAL CASE: A 60-year-old White man presented to the emergency department (ED) after having chest pain, shortness of breath, and palpitation for approximately 2 hours...
August 2015: American Journal of Emergency Medicine
Niall P Murphy
Opioid peptides are the endogenous ligands of opioid receptors, which are also the molecular target of naturally occurring and synthetic opiates, such as morphine and heroin. Since their discovery in the 1970s, opioid peptides, which are found widely throughout the central nervous system and the periphery, have been intensely studied because of their involvement in pain and pleasure. Over the years, our understanding of opioid peptides has widened to cover a multitude of functions, including learning and memory, affective state, gastrointestinal transit, feeding, immune function, and metabolism...
January 21, 2015: ACS Chemical Neuroscience
Takumi Fujita, Michael J Chen, Baoman Li, Nathan A Smith, Weiguo Peng, Wei Sun, Michael J Toner, Benjamin T Kress, Linhui Wang, Abdellatif Benraiss, Takahiro Takano, Su Wang, Maiken Nedergaard
Experimental advances in the study of neuroglia signaling have been greatly accelerated by the generation of transgenic mouse models. In particular, an elegant manipulation that interferes with astrocyte vesicular release of gliotransmitters via overexpression of a dominant-negative domain of vesicular SNARE (dnSNARE) has led to documented astrocytic involvement in processes that were traditionally considered strictly neuronal, including the sleep-wake cycle, LTP, cognition, cortical slow waves, depression, and pain...
December 10, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Erdogan Kavlak, Nihal Büker, Filiz Altug, Ali Kitis
BACKGROUND: Connective Tissue Massage (CTM) or Manipulation is a bodywork technique which lies at the interface between alternative approaches. The autonomic balancing responses to CTM can be useful in the treatment of anxiety. AIM: This study was planned to investigate the effects of connective tissue mobilization (CTM) on quality of life and emotional status in healthy subjects. Design; Prospective trial, Setting; Treatment and Population. The study was conducted on 100 volunteers (students)...
2014: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
Thierry Piche, Dorsa Pishvaie, Diane Tirouvaziam, Jerome Filippi, Raffaella Dainese, Marie Tonohouhan, Laurianne DeGalleani, Marie-Hélène Nébot-Vivinus, Jean-Luc Payrouse, Xavier Hébuterne
BACKGROUND: Osteopathy may decrease the severity of irritable bowel syndrome (IBS). About 35% of patients with quiescent Crohn's disease (CD) continue to suffer from IBS-like symptoms with impaired quality of life (Qol). We aimed to evaluate the effect of osteopathy on the severity of IBS-like symptoms in quiescent CD patients. METHODS: We prospectively included 38 patients with CD on remission over 12 months while receiving infliximab every 8 weeks. Patients were randomized 2/ 1 to receive three sessions of standardized osteopathy (n=25) at 15, 30, and 45 days after the last infusion of infliximab or simple follow-up...
December 2014: European Journal of Gastroenterology & Hepatology
Jun-Xiong Yang, Jian-Ping Zhang, Jian-Chun Yu, Jing-Xian Han
OBJECTIVE: To compare the difference in the clinical efficacy on primary trigeminal neuralgia (PTN) between the comprehensive therapy of electroacupuncture (EA) at qi streets acupoints combined with spinal regulation method and medication with carbamazepine (CBZ). METHODS: Sixty patients were randomized into a comprehensive therapy group (30 cases) and a medication group (30 cases). In the comprehensive therapy group, the acupoints at qi streets on the head such as Taiyang (EX-HN 5) and Sishencong (EX-HN 1) and those at qi streets on the chest and abdomen such as Shenshu (BL 23), Zhongwan (CV 12) and Guanyuan (CV 4), etc...
August 2014: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Abdelbaset Saleh, Magda Ahmad, Nabil Awadalla
Infectious Disease Global Case ReportsSESSION TYPE: Global Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Chest wall involvement is a rare manifestation of tuberculosis.Globally, musculoskeletal tuberculosis (TB) occurs in 1-3% of patients with TB, while TB of the chest wall constitutes 1% to 5% of all cases of musculoskeletal TB.The risk of medical laboratory staff acquiring TB is 5 times more than non laboratory workers.CASE PRESENTATION: 36 year-old male was presented with back pain and non-painful swelling on the left side of the chest anterior over a period of 3 months...
October 1, 2014: Chest
A Lopez-Lopez, J L Alonso Perez, J L González Gutierez, R La Touche, S Lerma Lara, H Izquierdo, J Fernández-Carnero
BACKGROUND: Three different types of manual therapy techniques for patients with neck pain and relationship with psychological factors has not been evaluated. AIM: To compare the effectiveness high velocity and low amplitude (HVLA) manipulation vs. posteroanterior mobilization (PA mob) vs. sustain appophyseal natural glide (SNAG) in the management of patients with neck pain and to evaluate the interaction with psychological factors. STUDY DESING: Randomized clinical trial...
April 2015: European Journal of Physical and Rehabilitation Medicine
M J Sanchez-Catalan, J Kaufling, F Georges, P Veinante, M Barrot
The ventral tegmental area (VTA) is a brain region processing salient sensory and emotional information, controlling motivated behaviors, natural or drug-related reward, reward-related learning, mood, and participating in their associated psychopathologies. Mostly studied for its dopamine neurons, the VTA also includes functionally important GABA and glutamate cell populations. Behavioral evidence supports the presence of functional differences between the anterior VTA (aVTA) and the posterior VTA (pVTA), which is the topic of this review...
December 12, 2014: Neuroscience
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