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JOURNAL ARTICLE
Eva Duvalyan, Sam Brondfield, Robert J Rushakoff, Mark S Anderson, Zoe Quandt
Immune checkpoint inhibitor (CPI)-induced diabetes mellitus (CPI-DM) is a rare immune-related adverse event (irAE). Patients and providers fear that continuing CPIs puts patients at risk for additional irAEs and thus may discontinue therapy. Currently, there are little data to inform this decision. Therefore, this study aims to elucidate whether discontinuing CPIs after diagnosis of CPI-DM impacts the development of future irAEs and cancer outcomes such as progression and death. Patients who developed CPI-DM during cancer treatment at UCSF from 1 July 2015 to 5 July 2023 were analyzed for cancer outcomes and irAE development...
April 25, 2024: Cancers
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JOURNAL ARTICLE
Lijun Tian, Cihang Lu, Weiping Teng
OBJECTIVE: Physical activity (PA) is closely related to our lives, and the effects of PA on thyroid function have not been elucidated. METHODS: Using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2012, we included 5877 participants and analyzed the associations of thyroid function with weekly physical activity (PAM, expressed in metabolic equivalents of task) and physical activity time (PAT) in American adults. Univariate and multivariate logistic analyses were used to demonstrate the associations of PAM and PAT with the primary outcome...
May 10, 2024: BMC Public Health
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JOURNAL ARTICLE
Michal Shani, Irit Hermesh, Ilan Feldhamer, Orna Reges, Gil Lavie, Ronen Arbel, Yael Wolff Sagy
BACKGROUND: A large vaccination campaign was initiated worldwide in December 2020 in order to prevent infection with SARS-CoV-2 and severe Covid-19 disease. However, long-term adverse effects of vaccination remain unclear. Therefore, our objective was to examine the association between vaccination and the incidence of autoimmune diagnoses in the first year after vaccine uptake. METHODS: This retrospective cohort study based on Clalit Health Services (CHS) comprehensive database compared the rates of immune-mediated diagnoses among BNT162b2 vaccinated versus unvaccinated individuals...
May 9, 2024: Vaccine
#24
REVIEW
Martin Aringer, Daniel Toro-Domínguez, Marta E Alarcón-Riquelme
SLE is a highly variable systemic autoimmune disease. Its immunopathological effector phase is partly understood. However, the background of its variability is not. SLE classification criteria have been relying on the clinical manifestations and standard autoimmune serology. This still holds true for the 2019 EULAR/ACR classification criteria. On one hand, this has led to significant precision in defining patients with SLE. On the other hand, the information in the criteria neither helps understanding the individual patient's pathophysiology, nor does it predict the efficacy of the available immunomodulatory therapies...
May 9, 2024: Best Practice & Research. Clinical Rheumatology
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JOURNAL ARTICLE
Jiao Qi, Hao Li, Yu Du, Yun Liu, Wenwen He, Jiaqi Meng, Ling Wei, Keke Zhang, Yi Lu, Xiangjia Zhu
High myopia is a leading cause of blindness worldwide, among which pathologic myopia, characterized by typical myopic macular degeneration, is the most detrimental. However, its pathogenesis remains largely unknown. Here, using an HuProt array, we first initiated a serological autoantibody profiling of high myopia and identified 18 potential autoantibodies, of which anti-LIMS1 autoantibody was validated by a customized focused microarray. Further subgroup analysis revealed its actual relevance to pathologic myopia, rather than simple high myopia without myopic macular degeneration...
May 8, 2024: Molecular & Cellular Proteomics: MCP
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JOURNAL ARTICLE
Hiroyuki Kurata, Md Harun-Or-Roshid, Md Mehedi Hasan, Sho Tsukiyama, Kazuhiro Maeda, Balachandran Manavalan
RNA modification serves as a pivotal component in numerous biological processes. Among the prevalent modifications, 5-methylcytosine (m5C) significantly influences mRNA export, translation efficiency and cell differentiation and are also associated with human diseases, including Alzheimer's disease, autoimmune disease, cancer, and cardiovascular diseases. Identification of m5C is critically responsible for understanding the RNA modification mechanisms and the epigenetic regulation of associated diseases. However, the large-scale experimental identification of m5C present significant challenges due to labor intensity and time requirements...
May 8, 2024: Methods: a Companion to Methods in Enzymology
#27
REVIEW
Clinton T Smith, Zhenyu Wang, Jamal S Lewis
Autoimmune diseases are burdensome conditions that affect a significant fraction of the global population. The hallmark of autoimmune disease is a host's immune system being licensed to attack its tissues based on specific antigens. There are no cures for autoimmune diseases. The current clinical standard for treating autoimmune diseases is the administration of immunosuppressants, which weaken the immune system and reduce auto-inflammatory responses. However, people living with autoimmune diseases are subject to toxicity, fail to mount a sufficient immune response to protect against pathogens, and are more likely to develop infections...
May 8, 2024: Advanced Drug Delivery Reviews
#28
REVIEW
Ryan Yellamaty, Shalini Sharma
Posttranscriptional maturation and export from the nucleus to the cytoplasm are essential steps in the normal processing of many cellular RNAs. The RNA helicase UAP56 (U2AF associated protein 56; also known as DDX39B) has emerged as a critical player in facilitating and co-transcriptionally linking these steps. Originally identified as a helicase involved in pre-mRNA splicing, UAP56 has been shown to facilitate formation of the A complex during spliceosome assembly. Additionally, it has been found to be critical for interactions between components of the exon junction and transcription and export complexes to promote the loading of export receptors...
May 8, 2024: Journal of Molecular Biology
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JOURNAL ARTICLE
Barbara Dreo, Anirudh Subramanian Muralikrishnan, Rusmir Husic, Angelika Lackner, Theresa Brügmann, Patrizia Haudum, Philipp Bosch, Jens Thiel, Johannes Fessler, Martin Stradner
OBJECTIVE: Rheumatoid Arthritis (RA) is a systemic autoimmune disease involving pro-inflammatory cytokines that can be therapeutically targeted by antibodies or kinase inhibitors. Nevertheless, these drugs fail in a subset of patients independent of the abundance of the targeted cytokines. We aim to explore the cellular basis of this phenomenon by analyzing the relation of cytokine abundance and activation of downstream signaling pathways in RA. METHODS: The study included 62 RA patients and 9 healthy controls (HC)...
May 8, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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JOURNAL ARTICLE
Sophia Damman, Persen Sukpornchairak, Amit Ahituv, Alex Chen, David Wang, Komal Sawlani, Claude Steriade, Hesham Abboud
OBJECTIVE: To report a novel anatomical pattern of autoimmune encephalitis characterized by strictly unilateral cortical inflammation and a clinical picture overlapping with late-onset Rasmussen's encephalitis. METHODS: We retrospectively gathered data of patients identified at two tertiary referral academic centers who met inclusion criteria. RESULTS: We identified twelve cases (average age 65, +/- 19.8 years, 58% female). All patients had unilateral cortical inflammation manifesting with focal seizures, cognitive decline, hemicortical deficits, and unilateral MRI and/or EEG changes...
April 26, 2024: Journal of Neuroimmunology
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JOURNAL ARTICLE
Huseyin Istanbullu, Gunes Coban, Ezgi Turunc, Cagla Disel, Bilge Debelec Butuner
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway mediates many cytokine and growth factor signals. Tyrosine kinase 2 (TYK2), one of the members of this pathway and the first described member of the JAK family. TYK2 associates with inflammatory and autoimmune diseases, cancer and diabetes. Here, we present novel compounds as selective inhibitors of the canonical kinase domain of TYK2 enzyme. These compounds were rationally designed and synthesized with appropriate reactions...
May 7, 2024: Bioorganic Chemistry
#32
JOURNAL ARTICLE
Marjolijn S W Quaak, Michiel S J S Buijze, Virginie J M Verhoeven, Clementien Vermont, Emmeline P Buddingh, Maud Heredia, Janneke N Samsom, Maarten J Titulaer, Annemarie M van Rossum, Sylvia Kamphuis, Rinze F Neuteboom
OBJECTIVES: We report on the therapeutic management of early-onset severe neurologic symptoms in cytotoxic T lymphocyte antigen-4 haploinsufficiency (CTLA-4h) and the presence of antibodies to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) as an important finding. METHODS: This is a case report from a Dutch academic hospital. Repeated clinical examinations, repeated brain MRI and extended diagnostics on serum and CSF were performed...
July 2024: Neurology® Neuroimmunology & Neuroinflammation
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JOURNAL ARTICLE
Pablo Mesa-Del-Castillo, Inés Yago Ugarte, J M Bolarín, David Martínez, Berta López Montesinos, Honorio Barranco González, Inmaculada Calvo Penadés, Lucia Lacruz Pérez, Daniel Clemente, Juan Carlos Robledillo, Isabel Valls Ferrán, Beatriz Bravo Mancheño, Marina Rubio Plats, Laura Martín Pedraz, Carmen Alba Linero, Belén Sevilla-Pérez, J L García-Serrano, Maria Concepcion Mir-Perelló, Noelia Druetta, Alex Souto, Fernando Lopez-Lopez, Cristina Zarallo-Reales, María Jerez Fidalgo, Jorge Solana Fajardo, Natalia Palmou Fontana, Rosalia Demetrio Pablo, Mari Carmen Pinedo, Alex Fonollosa, Vega Jovani Casano, Jose Juan Mondejar García, Anahy Brandy, Alba García López, M Esteban-Ortega, Teresa Reinoso, Joan Calzada-Hernández, Ana Llorca Cardeñosa, César Gavilán Martín, Encarna Mengual Verdú, Mari Paz Martínez Vidal, Neus Quilis Martí, M C Alvarado, Jaime De Inocencio, Beatriz Alonso-Martín, Sheila Recuero-Diaz, Ester Carreño, Juan Carlos Nieto González, Lucia Ibares, Jose Rosas Gómez de Salazar, Juan Luis Sánchez Sevila
OBJECTIVE: To characterize and describe clinical experience with childhood-onset non-infectious uveitis. STUDY DESIGN: A multicenter retrospective multidisciplinary national web-based registry of 507 patients from 21 hospitals was analyzed. Cases were grouped as immune disease-associated (IMDu), idiopathic (IDIu) or ophthalmologically distinct. Characteristics of juvenile idiopathic arthritis-associated (non-HLA-B27-related) uveitis (JIAu), IDIu, and pars planitis (PP) were compared...
May 10, 2024: Ocular Immunology and Inflammation
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JOURNAL ARTICLE
Yuhang Zhou, Xiuping Yin, Chenyu Wang, Donglin Yu
Multiple studies have indicated a potential correlation between immune-mediated inflammatory diseases (IMIDs) and Frozen shoulder (FS). To explore the genetic causal relationship between IMIDs and FS using 2-sample Mendelian randomization (MR) analysis. Genome-wide association study (GWAS) summary data for FS were obtained from Green's study, while data for 10 IMIDs were sourced from the FinnGen Consortium. The MR analysis was performed using inverse variance weighting, MR Egger, and weighted median methods...
May 10, 2024: Medicine (Baltimore)
#35
JOURNAL ARTICLE
Wenwen Yang
Primary Sjögren Syndrome (pSS) is a chronic autoimmune disease that primarily affects exocrine glands and can lead to various extraglandular manifestations, including secondary immune thrombocytopenia (ITP). Understanding the clinical and hematological differences in pSS patients with and without secondary ITP is crucial for improved patient management and treatment strategies. This retrospective study, conducted from January 2020 to December 2023, involved a cohort of pSS patients, dividing them into 2 groups: those with secondary ITP and those without...
May 10, 2024: Medicine (Baltimore)
#36
REVIEW
Zhendong He, Hanyou Mo, Leting Zheng, Wen Zeng, Jing Wen, Zhanrui Chen, Fang Qin
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, which is mainly characterized by joint swelling, pressure pain and joint destruction. Some patients may suffer from a variety of serious complications, which require prompt diagnosis and treatment. Otherwise, the patient condition may deteriorate rapidly, leading to premature death. OBJECTIVE: We reported a case of RA combined with hyperferritinemic syndrome and capillary leak syndrome (CLS) that was successfully treated with tocilizumab (TCZ), with the aim of improving diagnostic ideas for clinicians and consequently improving the diagnosis and treatment of the hyperferritinemic syndrome and CLS...
May 10, 2024: Medicine (Baltimore)
#37
JOURNAL ARTICLE
Chuan Qin, Min Zhang, Da-Peng Mou, Luo-Qi Zhou, Ming-Hao Dong, Liang Huang, Wen Wang, Song-Bai Cai, Yun-Fan You, Ke Shang, Jun Xiao, Di Wang, Chun-Rui Li, Yi Hao, Michael Heming, Long-Jun Wu, Gerd Meyer Zu Hörste, Chen Dong, Bi-Tao Bu, Dai-Shi Tian, Wei Wang
Chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of neurological autoimmune diseases is promising, but CAR T cell kinetics and immune alterations after treatment are poorly understood. Here, we performed single-cell multi-omics sequencing of paired cerebrospinal fluid (CSF) and blood samples from patients with neuromyelitis optica spectrum disorder (NMOSD) treated with anti-B cell maturation antigen (BCMA) CAR T cells. Proliferating cytotoxic-like CD8+ CAR T cell clones were identified as the main effectors in autoimmunity...
May 10, 2024: Science Immunology
#38
JOURNAL ARTICLE
Qian Li, Ningyu An, Cheng Liu, Yungang Ding, Cuixia Yang, Xiumei Ma, Wei Yang, Junfeng Piao, Jinyan Zhu, Junxiu Liu
Thyroid-associated ophthalmopathy (TAO) is the most prevalent orbital disease in adults caused by an autoimmune disorder, which can lead to disfigurement and vision impairment. Developing effective treatments for this condition presents challenges due to our limited understanding of its underlying immune aberrations. In this study, we profiled the immune components in the peripheral blood of patients with TAO as well as healthy individuals, utilizing single-cell RNA sequencing and B-cell receptor repertoires (BCR) analysis...
May 9, 2024: Aging
#39
JOURNAL ARTICLE
Amanda Oliver, Joshua Boster, Whittney Warren, Sebastian Welsh
Hemoptysis is a rare presenting symptom in pediatric and young adult patients with a highly variable outcome ranging from an isolated mild occurrence to severe illness and death. Exercise-induced pulmonary hemorrhage (EIPH) has several reports in adult literature but has not previously been reported in pediatric patients. A 12-year-old female with a history of trisomy X (47, XXX), obesity, depression, anxiety, and obstructive sleep apnea presented to the pediatric pulmonology clinic after several episodes of hemoptysis...
May 10, 2024: Military Medicine
#40
JOURNAL ARTICLE
Narges Maleki, Maryam Rezapour Kalkhoran, Mohammad Sajad Emami Aleagha, Abdolamir Allameh
Treatment of multiple sclerosis (MS) remains a major challenge. The aim of this study was to evaluate the therapeutic potential of mesenchymal stem cells (MSCs) engineered with secreted Klotho (SKL) in an experimental autoimmune encephalomyelitis (EAE) mouse model of MS. EAE was induced in mice. MSCs or MSCs engineered with SKL (SKL-MSCs) were administered to EAE mice at the onset of disease. Hematoxylin-eosin and luxol fast blue staining were performed to evaluate histopathological changes. Expression of pro-inflammatory (TNF-α, IFN-γ, and IL-17) and anti-inflammatory (IL-10) cytokines was determined in the spinal cord using real-time PCR...
May 10, 2024: Molecular Neurobiology
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