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Infectious bronchitis virus

Jeanne M Sisk, Matthew B Frieman, Carolyn E Machamer
Enveloped viruses gain entry into host cells by fusing with cellular membranes, a step that is required for virus replication. Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and infectious bronchitis virus (IBV), fuse at the plasma membrane or use receptor-mediated endocytosis and fuse with endosomes, depending on the cell or tissue type. The virus spike (S) protein mediates fusion with the host cell membrane. We have shown previously that an Abelson (Abl) kinase inhibitor, imatinib, significantly reduces SARS-CoV and MERS-CoV viral titres and prevents endosomal entry by HIV SARS S and MERS S pseudotyped virions...
March 20, 2018: Journal of General Virology
Shihong Yan, Jing Zhao, Deqiong Xie, Xiuying Huang, Jinlong Cheng, Ye Guo, Changqing Liu, Zhijun Ma, Huiming Yang, Guozhong Zhang
Avian infectious bronchitis (IB) is a highly contagious disease caused by avian infectious bronchitis virus (IBV), which is a considerable economic threat to the poultry industry. QX-like IBV strains have increasingly emerged in China in recent years. Hence, development of a specific vaccine to guard against their potential threat is important. In this study, we sought to develop an attenuated vaccine strain. First, attenuated QX-like IBV strain SZ130 was created by continuous passage in chicken embryos for 130 generations, and then its safety was tested...
February 26, 2018: Vaccine
Cintia Hiromi Okino, Maria de Fátima Silva Montassier, Andressa Peres DE Oliveira, Helio José Montassier
A method based on Melting Temperature analysis of Hypervariable regions (HVR) of S1 gene within a RT-qPCR was developed to detect different genotypes of avian infectious bronchitis virus (IBV) and identify the Mass genotype. The method was able to rapidly identify the Mass genotype among IBV field isolates, vaccine attenuated strains and reference M41 strain in allantoic liquid and also directly in tissues. The RT-qPCR developed detected the virus in both tracheal and pulmonary samples from M41-infected or H120-infected birds, in a larger post-infection period compared to detection by standard method of virus isolation...
February 27, 2018: Journal of Veterinary Medical Science
Dauda G Bwala, Solomon Ponman, Neil Duncan, Daniel B R Wandrag, Celia Abolnik
Mycoplasma gallisepticum (MG) is the primary cause of chronic respiratory disease in poultry. We investigated the protective efficacy of the live attenuated ts-11 and 6/85 MG vaccines against a local MG strain, and in order to enhance symptoms and mimic a typical field situation, we co-infected birds with a virulent strain of QX-like infectious bronchitis virus (IBV). Both vaccines showed similar ability to protect infected chickens from clinical signs, although ts-11 performed slightly better. Despite the lower protection against clinical disease, 6/85-vaccinated birds had significantly (P≤0...
February 16, 2018: Avian Pathology: Journal of the W.V.P.A
Aruna Amarasinghe, Mohamed Sarjoon Abdul-Cader, Zahraa Almatrouk, Frank van der Meer, Susan C Cork, Susantha Gomis, Mohamed Faizal Abdul-Careem
Infectious bronchitis virus (IBV) infection is a major cause of economic losses to the poultry industry. Due to limitations in current control measures, alternative approaches, based on thorough understanding of the host responses are required. As one of the key component of the avian immune system, the innate immune system has a crucial role in limiting virus replication at the initial stage of the infection. As parts of the innate host response, macrophages and cytokines, such as interleukin (IL)-1β, are critical components as shown in other host-virus infection models...
February 2018: Veterinary Microbiology
M Elhamouly, T Terada, T Nii, N Isobe, Y Yoshimura
Infectious bronchitis virus (IBV) is an enveloped RNA virus that causes deformities in eggshells. The aim of this study was to investigate the innate immune response to IBV, and to determine whether prostaglandin (PG) E2, which is synthesized during inflammation, is involved in the innate immune response in the uterine mucosa. The effects of intra-oviductal inoculation with attenuated IBV (aIBV) on the expression of viral RNA recognition receptors and innate antiviral factors were examined by real-time PCR and immunohistochemistry, and on PGE2 levels by ELISA...
January 11, 2018: Theriogenology
Arianne Brown Jordan, Victor Gongora, Dane Hartley, Christopher Oura
Viral pathogens cause devastating economic losses in poultry industries worldwide. The Caribbean region, which boasts some of the highest rates of poultry consumption in the world, is no exception. This review summarizes evidence for the circulation and spread of eight high-priority, economically important poultry viruses across the Caribbean region. Avian influenza virus (AIV), infectious bronchitis virus (IBV), Newcastle disease virus (NDV), infectious laryngotracheitis virus (ILTV), avian metapneumovirus (aMPV), infectious bursal disease virus (IBDV), fowl adenovirus group 1 (FADV Gp1), and egg drop syndrome virus (EDSV) were selected for review...
January 26, 2018: Veterinary Sciences
Steven J van Beurden, Alinda J Berends, Annika Krämer-Kühl, Dieuwertje Spekreijse, Gilles Chenard, Hans-Christian Philipp, Egbert Mundt, Peter J M Rottier, M Hélène Verheije
Avian coronavirus infectious bronchitis virus (IBV) is a respiratory pathogen of chickens, causing severe economic losses in poultry industry worldwide. Live attenuated viruses are widely used in both the broiler and layer industry because of their efficacy and ability to be mass applied. Recently, we established a novel reverse genetics system based on targeted RNA recombination to manipulate the genome of IBV strain H52. Here we explore the possibilities to attenuate IBV in a rational way in order to generate safe and effective vaccines against virulent IBV (van Beurden et al...
January 20, 2018: Vaccine
Arianne Brown Jordan, Pompei Bolfa, Silvia Marchi, Shakera Hemmings, Tashard Major, Rod Suepaul, Lemar Blake, Christopher Oura
Backyard poultry farms in Trinidad and Tobago (T&T) play a vital role in providing food and income for rural communities. There is currently no information on the presence and circulation of pathogens in backyard poultry farms in T&T, and little is known in relation to the potential risks of spread of these pathogens to the commercial poultry sector. In order to address this, serum samples were collected from 41 chickens on five backyard farms taken from selected locations in Trinidad. Samples were tested for antibodies to seven priority pathogens of poultry by enzyme-linked immunosorbent assay (ELISA)...
January 20, 2018: Veterinary Sciences
Guillaume Croville, Charlotte Foret, Pauline Heuillard, Alexis Senet, Mattias Delpont, Mohammed Mouahid, Mariette F Ducatez, Faouzi Kichou, Jean-Luc Guerin
Respiratory syndromes (RS) are among the most significant pathological conditions in food animals and are caused by complex coactions of pathogens and environmental factors. In poultry, low pathogenic avian Influenza A viruses, metapneumoviruses, infectious bronchitis virus, infectious laryngotracheitis virus, Mycoplasma spp. Escherichia coli and/or Ornithobacterium rhinotracheale (ORT) in turkeys, are considered as key co-infectious agents of respiratory syndromes. Aspergillus sp., Pasteurella multocida, Avibacterium paragallinarum or Chlamydia psittaci may also be involved in respiratory outbreaks...
January 19, 2018: Avian Pathology: Journal of the W.V.P.A
N P Khanh, S W Tan, S K Yeap, D A Satharasinghe, M Hair-Bejo, T N Bich, A R Omar
Infectious bronchitis virus (IBV) is one of the major poultry pathogens of global importance. However, the prevalence of IBV strains in Malaysia is poorly characterized. The partial genomic sequences (6.8 kb) comprising the S-3a/3b-E-M-intergenic region-5a/5b-N gene order of 11 Malaysian IBVs isolated in 2014 and 2015 were sequenced using next-generation sequencing technology. Phylogenetic and pairwise sequence comparison analysis showed that the isolated IBVs are divided into two groups. Group 1 (IBS124/2015, IBS125/2015, IBS126/2015, IBS130/2015, IBS131/2015, IBS138/2015, and IBS142/2015) shared 90%-95% nucleotide and deduced amino acid similarities to the QX-like strain...
December 2017: Avian Diseases
Sakhia F Z Belkasmi, Siham Fellahi, Sajid Umar, Mattias Delpont, Maxence Delverdier, Marie-Noëlle Lucas, Céline Bleuart, Faouzi Kichou, Saâdia Nassik, Jean-Luc Guerin, Ouafaa Fassi Fihri, Mariette F Ducatez, Mohammed El Houadfi
The ability of commercial vaccines H120 and 4/91 to protect against Moroccan-Italy 02 infectious bronchitis virus (Mor-It02) was investigated in specific-pathogen-free (SPF) chickens and commercial broiler chickens. Commercial broiler chicks (Experiment 1) were vaccinated at the hatchery with H120 vaccine at Day 1, and challenged at Day 21 with 104 50% egg-infective dose (EID50) of Mor-It02. All chicks were observed daily for clinical signs attributable to Mor-It02 infection during the 10 days postchallenge (pc)...
December 2017: Avian Diseases
Hossein Rostami, Alireza Seidavi, Mohammad Dadashbeiki, Yadollah Asadpour, João Simões, Assar Ali Shah, Vito Laudadio, Caterina Losacco, Antonella Perillo, Vincenzo Tufarelli
The aim of the present study was to evaluate the effect rosemary (Rosmarinus officinalis L.) powder (RP) and vitamin E (VE) at different levels on humoral immunity of broilers during a 42-day production cycle. A total of 270 1-day-old male chicks were assigned to nine groups with three replicates of ten birds each, and diets were supplemented with 0, 0.5, or 1.0% RP and 0, 100, or 200 mg/kg VE, respectively. Commercial-inactivated vaccines against avian influenza (AI) and Newcastle disease (ND) viruses, and living infectious bronchitis virus (IBV) vaccine were administered by spray method...
January 12, 2018: Environmental Science and Pollution Research International
Xin Yang, Jianan Li, Hui Liu, Peng Zhang, Danyu Chen, Shuai Men, Xiaocheng Li, Hongning Wang
Infectious bronchitis (IB) is a highly contagious respiratory disease of chickens, which is caused by the infectious bronchitis virus (IBV). The innate immune response is crucial for antiviral infections and revealing the pathogenic mechanisms of IBV. In this study, we presents an evaluation of interferon (I, II and III IFNs) in renal and tracheal samples from chickens experimentally infected previously vaccinated or not. The results suggest differential expression of chicken interferon, among them type I IFN elaborate a major role in fighting off virus...
January 9, 2018: Microbial Pathogenesis
M S Khilji, M A Sandhu, M S Yousaf, A A Saeed, H U Rehman, H Zaneb, M A Rashid
Thyroid hormones (THs) are involved in the development of lymphoid organs and regulation of immune function in birds. However, their role as an immune-modulator in the hyperthyroid state is still debatable. To explore the interrelationship of thyroxine (T4 ) and the immune system, chicks were divided into three groups. Group I was comprised of control birds, who received the basal diet while group II and III were given diets supplemented with 5 μg and 10 μg thyroxine/kg feed, respectively, from 15 to 28 days of age...
January 12, 2018: Journal of Animal Physiology and Animal Nutrition
Sergio E L da Silva, Helena L Ferreira, Andrea F Garcia, Felipe E S Silva, Roberto Gameiro, Carolina U F Fabri, Dielson S Vieira, Tereza C Cardoso
To establish an association between mitochondrial dysfunction and apoptosis following infectious bronchitis virus (IBV) infection, HD11 avian macrophage cells were infected with the Massachusetts 41 (M41) strain. Our results show that the M41 strain of IBV induced cytopathic effects followed by the release of new viral particles. Elevated numbers of apoptotic cells were observed at 24, 48 and 72 h post-infection (p.i.). Viral infection was associated with mitochondrial membrane depolarization and reactive oxygen species (ROS) production at all of the examined timepoints p...
January 4, 2018: Archives of Virology
Rafia Parveen, Iqra Farooq, Showkat Ahangar, Salik Nazki, Zahoor Dar, Tanveer Dar, Shayaib Kamil, Pervaiz Dar
Infectious bronchitis virus (IBV) is responsible for significant economic losses to the poultry industry across the world. The enormous genetic diversity of IBV poses difficulty in diagnosing and controlling the virus. To understand the nature of IBV prevalent in the Kashmir Himalayas, we characterized two field strains, isolated from non-immunized broiler chickens, by sequence and phylogenetic analysis of S1 subunit of the spike glycoprotein. The analysis revealed both the isolates are identical to each other, with nucleotide and amino acid sequence identities of 99...
December 2017: Virusdisease
Arianne Brown Jordan, Jamie Sookhoo, Lemar Blake, Paul Crooks, Zul Mohammed, Judy Molawatti-Bisnath, Christine V F Carrington, Christopher A L Oura
Viruses affecting poultry cause significant levels of disease leading to severe economic losses among poultry farmers worldwide. The Americas region continues to be vulnerable to the spread of poultry viruses across the continents and Caribbean island chains. In Trinidad and Tobago (T&T) there is limited information on the viruses circulating in poultry. Many flock are vulnerable to infection and there are occasional outbreaks of disease resulting in high levels of morbidity and mortality. This study aims to identify important viruses of poultry circulating in T&T through a broad-based surveillance approach...
January 1, 2018: Preventive Veterinary Medicine
To Sing Fung, Ding Xiang Liu
Mitogen-activated protein kinases (MAPKs) are conserved protein kinases that regulate a variety of important cellular signaling pathways. Among them, c-Jun N-terminal kinases (JNK) are known to be activated by various environmental stresses including virus infections. Previously, activation of the JNK pathway has been detected in cells infected with several coronaviruses. However, detailed characterization of the pathway as well as its implication in host-virus interactions has not been fully investigated. Here we report that the JNK pathway was activated in cells infected with the avian coronavirus infectious bronchitis virus (IBV)...
December 13, 2017: Cell Death & Disease
Nacira Laamiri, Rim Aouini, Boutheina Marnissi, Abdeljelil Ghram, Issam Hmila
A one-step multiplex real-time reverse transcription-PCR (rRT-PCR) assay was developed for simultaneous detection and quantification of four avian respiratory viruses: avian influenza virus (AIV), infectious bronchitis virus (IBV), Newcastle disease virus (NDV) and infectious laryngotracheitis virus (ILTV). In comparison with the singleplex rRT-PCR, the specificity, the sensitivity and the reproducibility of the new assay were evaluated and validated using 70 clinical samples. The optimal cutoff point, the corresponding limit of quantification (LoQ) and the limit of detection (LoD) were statistical established based on receiver operating characteristic (ROC) curve analysis...
February 2018: Virology
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